PLEKHM1

pleckstrin homology and RUN domain containing M1
General Information
Name pleckstrin homology and RUN domain containing M1
Alias
  • pleckstrin homology domain-containing family M member 1
  • 162 kDa adapter protein
  • PH domain-containing family M member 1
  • pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms KIAA0356 AP162 B2 OPTA3 OPTB6
Gene_family Pleckstrin homology domain containing
organism Homo sapiens
entrez_id 9842
location 17q21.31
transcript_count 14
exon_count 17
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
      Stringdb Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion. Positively regulates lysosome peripheral distributi [...]
      nextProt Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    PLEKHM1 BioGRID ORF3a GeneID BioGRID Affinity Capture-Western; Co-localization
    PLEKHM1 BioGRID VPS33A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    PLEKHM1 BioGRID VPS18 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    PLEKHM1 BioGRID VPS11 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    PLEKHM1 BioGRID VPS41 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    PLEKHM1 BioGRID VPS39 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    PLEKHM1 BioGRID RAB7A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization; Proximity Label-MS; Reconstituted Complex
    PLEKHM1 BioGRID ORF1ab GeneID BioGRID Protein-peptide
    PLEKHM1 BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
    PLEKHM1 BioGRID ARL8B GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    PLEKHM1 BioGRID GABARAP GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    PLEKHM1 BioGRID RRAGA GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID VTI1B GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID RRAGB GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID STX8 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID STX7 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID NPRL3 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID TSC2 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID VAMP7 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID SEC13 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID RHEB GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID MAPK1 GeneID BioGRID Biochemical Activity
    PLEKHM1 BioGRID LAMP2 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    PLEKHM1 BioGRID LAMP1 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID MTOR GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
    PLEKHM1 BioGRID RAB7A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    PLEKHM1 BioGRID RICTOR GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    PLEKHM1 BioGRID SEH1L GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID PRR5L GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID WDR59 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID MAPKAP1 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID VPS16 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID MLST8 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    PLEKHM1 BioGRID RPTOR GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    PLEKHM1 BioGRID LAMTOR1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    PLEKHM1 BioGRID MIOS GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID LAMTOR2 GeneID BioGRID Affinity Capture-MS
    PLEKHM1 BioGRID MAP1LC3B GeneID BioGRID Two-hybrid
    PLEKHM1 BioGRID CTDSP1 GeneID BioGRID Two-hybrid
    PLEKHM1 BioGRID TRIM54 GeneID BioGRID Two-hybrid
    PLEKHM1 BioGRID NDEL1 GeneID BioGRID Affinity Capture-Western
    PLEKHM1 BioGRID DEF8 GeneID BioGRID Affinity Capture-Western
    PLEKHM1 BioGRID FAM98A GeneID BioGRID Affinity Capture-Western
    PLEKHM1 BioGRID TPX2 GeneID BioGRID Affinity Capture-Western
    PLEKHM1 BioGRID MAP3K7 GeneID BioGRID Affinity Capture-Western
    PLEKHM1 BioGRID RAP1B GeneID BioGRID Affinity Capture-Western
    PLEKHM1 BioGRID KIFC1 GeneID BioGRID Affinity Capture-Western
    PLEKHM1 BioGRID VIRMA GeneID BioGRID Affinity Capture-RNA
    PLEKHM1 BioGRID TP63 GeneID BioGRID Negative Genetic
    PLEKHM1 BioGRID HNRNPL GeneID BioGRID Affinity Capture-RNA
    PLEKHM1 BioGRID GADD45G GeneID BioGRID Two-hybrid
    PLEKHM1 BioGRID MAPK6 GeneID BioGRID Two-hybrid
    PLEKHM1 BioGRID BID GeneID BioGRID Two-hybrid
    PLEKHM1 None MUC2 GeneID HPRD None
    PLEKHM1 None MOB4 GeneID HPRD None
    PLEKHM1 None EIF2S2 GeneID HPRD None
    PLEKHM1 None PAFAH1B3 GeneID HPRD None
    PLEKHM1 None SERPINB9 GeneID HPRD None
    PLEKHM1 BioGRID MOB4 GeneID BioGRID Two-hybrid
    PLEKHM1 BioGRID EIF2S2 GeneID BioGRID Two-hybrid
    PLEKHM1 BioGRID SERPINB9 GeneID BioGRID Two-hybrid
    PLEKHM1 BioGRID PAFAH1B3 GeneID BioGRID Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    PLEKHM1 SLC45A3 0 0 143 179 1 1
    PLEKHM1 KANSL1 0 0 400 400 1 1
    PLEKHM1 SMURF1 0 0 160 159 1 1
    PLEKHM1 DCAKD 0 0 452 469 1 1
    PLEKHM1 SH3GL2 0 0 145 169 1 1
    PLEKHM1 ATG101 0 0 325 339 1 2
    PLEKHM1 FCHSD1 0 0 177 210 1 1
    PLEKHM1 HNRNPL 270 0 0 270 1 1
    PLEKHM1 PPIA 0 0 0 162 1 1
    PLEKHM1 LRRC37A3 0 0 310 309 1 1
    PLEKHM1 NDE1 0 0 62 349 1 1
    PLEKHM1 ATG12 0 0 324 323 1 2
    PLEKHM1 HN1L 0 0 118 210 1 1
    PLEKHM1 SLC35A4 0 0 147 217 1 1
    PLEKHM1 SAMHD1 0 0 49 195 1 1
    PLEKHM1 RIN1 0 0 0 189 1 1
    PLEKHM1 HIP1R 0 0 143 196 1 1
    PLEKHM1 FAM98A 270 0 292 498 1 1
    PLEKHM1 PI4K2A 0 0 391 404 1 1
    PLEKHM1 CSF1 0 0 81 181 1 1
    PLEKHM1 WDR91 0 0 180 377 1 1
    PLEKHM1 PATL1 0 0 124 161 1 1
    PLEKHM1 PHB2 0 0 181 186 1 1
    PLEKHM1 WNT3 0 0 135 229 1 1
    PLEKHM1 PPIAL4D 0 0 0 162 1 1
    PLEKHM1 ATG16L1 0 0 324 323 1 2
    PLEKHM1 RAB2B 0 0 180 194 1 1
    PLEKHM1 TMUB1 0 0 180 185 1 1
    PLEKHM1 DNAJC13 0 0 92 175 1 1
    PLEKHM1 PTH 0 0 134 188 1 1
    PLEKHM1 PKN2 0 0 0 154 1 1
    PLEKHM1 PIGL 0 0 134 229 1 1
    PLEKHM1 TBC1D25 0 0 261 309 1 1
    PLEKHM1 TOP2B 0 0 0 181 1 1
    PLEKHM1 RGPD8 0 0 0 153 1 1
    PLEKHM1 TFE3 0 0 123 157 1 1
    PLEKHM1 LRRK2 0 0 181 192 1 2
    PLEKHM1 MAPK11 0 0 0 196 1 1
    PLEKHM1 ZDHHC11 0 0 193 199 1 1
    PLEKHM1 RUFY2 0 0 205 205 1 1
    PLEKHM1 MAPT 0 0 336 345 1 2
    PLEKHM1 BECN1 0 0 484 513 1 2
    PLEKHM1 SLC41A1 0 0 193 194 1 1
    PLEKHM1 TTLL4 0 0 141 164 1 1
    PLEKHM1 PLXDC1 0 0 0 264 1 1
    PLEKHM1 PFKFB1 0 0 241 259 1 1
    PLEKHM1 RAB3D 0 0 167 179 1 1
    PLEKHM1 SGK223 0 0 125 165 1 1
    PLEKHM1 SEC62 0 0 129 191 1 1
    PLEKHM1 CALCOCO2 0 0 554 554 1 2
    PLEKHM1 ATG5 0 0 324 323 1 2
    PLEKHM1 PLCD3 0 0 280 280 1 1
    PLEKHM1 ATP4A 0 0 537 537 1 1
    PLEKHM1 TPPP 0 0 97 251 1 1
    PLEKHM1 PLEKHM2 0 0 468 252 1 2
    PLEKHM1 AP4E1 0 0 125 170 1 1
    PLEKHM1 TP63 209 0 0 209 1 2
    PLEKHM1 OSBP 0 0 223 271 1 1
    PLEKHM1 SMARCA4 0 0 124 182 1 1
    PLEKHM1 ENSG00000100926 0 0 0 196 1 1
    PLEKHM1 SPI1 0 0 70 190 1 1
    PLEKHM1 CTSB 0 0 140 199 1 2
    PLEKHM1 CTSK 0 0 322 448 1 1
    PLEKHM1 HOXB8 0 0 141 161 1 1
    PLEKHM1 SMARCD2 0 0 97 205 1 1
    PLEKHM1 OPTN 0 0 415 414 1 2
    PLEKHM1 PSMC5 0 0 90 235 1 1
    PLEKHM1 TBC1D14 0 0 143 162 1 2
    PLEKHM1 ARFGAP2 0 0 170 187 1 1
    PLEKHM1 PKN1 0 0 69 288 1 1
    PLEKHM1 RGPD3 0 0 0 153 1 1
    PLEKHM1 STX7 0 0 324 412 1 2
    PLEKHM1 ULK1 0 0 391 404 1 2
    PLEKHM1 RGPD4 0 0 0 153 1 1
    PLEKHM1 MAPKAPK3 0 0 0 189 1 1
    PLEKHM1 IKBKG 0 0 112 219 1 1
    PLEKHM1 AMDHD2 0 0 207 263 1 1
    PLEKHM1 CEP95 0 0 218 236 1 1
    PLEKHM1 USP30 0 0 136 172 1 1
    PLEKHM1 RANBP1 0 0 0 153 1 1
    PLEKHM1 ATG10 0 0 270 270 1 2
    PLEKHM1 AADAC 0 0 122 208 1 1
    PLEKHM1 FAM20C 0 0 180 228 1 1
    PLEKHM1 MAP1LC3B 0 0 290 447 1 2
    PLEKHM1 AGFG1 0 0 154 153 1 1
    PLEKHM1 VPS33B 0 0 126 218 1 1
    PLEKHM1 GLIS1 0 0 100 154 1 1
    PLEKHM1 ATG7 0 0 324 338 1 2
    PLEKHM1 PTPRF 0 0 66 163 1 1
    PLEKHM1 FLT3 0 0 0 160 1 1
    PLEKHM1 VTI1B 0 0 231 279 1 2
    PLEKHM1 CTSD 0 0 147 203 1 2
    PLEKHM1 RNF26 0 0 152 151 1 1
    PLEKHM1 TRIM54 192 0 0 213 1 1
    PLEKHM1 HYI 0 0 163 163 1 1
    PLEKHM1 FAM20A 0 0 180 270 1 1
    PLEKHM1 AIPL1 0 0 91 503 1 1
    PLEKHM1 AMBRA1 0 0 243 249 1 2
    PLEKHM1 RDM1 0 0 150 456 1 1
    PLEKHM1 FAM134B 0 0 340 355 1 1
    PLEKHM1 ACBD4 0 0 301 301 1 1
    PLEKHM1 MAPK14 0 0 0 196 1 1
    PLEKHM1 SGSM1 0 0 161 169 1 1
    PLEKHM1 GABARAP 0 0 928 929 1 2
    PLEKHM1 TRAFD1 0 0 238 243 1 1
    PLEKHM1 TNFRSF11A 0 0 540 540 1 1
    PLEKHM1 KIAA0226 0 0 294 159 1 1
    PLEKHM1 NFATC1 0 0 77 219 1 1
    PLEKHM1 PI4KB 0 0 186 206 1 1
    PLEKHM1 RUNDC3A 0 0 160 167 1 1
    PLEKHM1 WIPI1 0 0 335 362 1 2
    PLEKHM1 ATG2A 0 0 204 262 1 2
    PLEKHM1 VPS41 0 0 161 308 1 1
    PLEKHM1 EPN3 0 0 51 185 1 1
    PLEKHM1 PAFAH1B3 43 0 125 261 1 1
    PLEKHM1 KLC2 0 0 143 182 1 1
    PLEKHM1 ALMS1 0 0 106 173 1 1
    PLEKHM1 SLC39A13 0 0 96 202 1 1
    PLEKHM1 SPATA32 0 0 361 361 1 1
    PLEKHM1 NDEL1 270 0 262 571 1 1
    PLEKHM1 TECPR1 0 0 261 307 1 2
    PLEKHM1 TBC1D17 0 0 135 153 1 1
    PLEKHM1 GBA 0 0 103 164 1 1
    PLEKHM1 NAA20 0 0 142 249 1 1
    PLEKHM1 GNPNAT1 0 0 108 244 1 1
    PLEKHM1 BLNK 0 0 46 268 1 1
    PLEKHM1 CCDC62 0 0 181 198 1 1
    PLEKHM1 PTPRE 0 0 0 157 1 1
    PLEKHM1 DVL2 0 0 141 192 1 1
    PLEKHM1 MEGF10 0 0 103 164 1 1
    PLEKHM1 MED13L 0 0 0 162 1 1
    PLEKHM1 EPG5 0 0 518 576 1 2
    PLEKHM1 TBC1D20 0 0 86 181 1 1
    PLEKHM1 KXD1 0 0 242 241 1 1
    PLEKHM1 TP53INP2 0 0 127 187 1 2
    PLEKHM1 STX8 0 0 252 466 1 2
    PLEKHM1 ARHGAP22 0 0 0 156 1 1
    PLEKHM1 EHD3 0 0 0 189 1 1
    PLEKHM1 CHMP4B 0 0 48 565 1 2
    PLEKHM1 ACY3 0 0 0 372 1 1
    PLEKHM1 BPIFB3 0 0 134 282 1 1
    PLEKHM1 CCPG1 0 0 323 341 1 1
    PLEKHM1 RAB1B 0 0 55 153 1 2
    PLEKHM1 WDFY3 0 0 307 322 1 2
    PLEKHM1 CSF1R 0 0 57 194 1 1
    PLEKHM1 UVRAG 0 0 379 462 1 2
    PLEKHM1 WDR45 0 0 142 161 1 2
    PLEKHM1 ACMSD 0 0 155 162 1 1
    PLEKHM1 ATG4B 0 0 295 319 1 2
    PLEKHM1 ATP12A 0 0 535 535 1 1
    PLEKHM1 OXA1L 0 0 90 259 1 1
    PLEKHM1 RAB7A 486 0 979 990 1 2
    PLEKHM1 DRAM1 0 0 66 220 1 2
    PLEKHM1 NAT8 0 0 96 210 1 1
    PLEKHM1 WIPI2 0 0 376 401 1 2
    PLEKHM1 FAM218A 0 0 151 150 1 1
    PLEKHM1 TPX2 270 0 0 270 1 1
    PLEKHM1 CCNT2 0 0 91 152 1 1
    PLEKHM1 TECPR2 0 0 322 365 1 2
    PLEKHM1 TNF 0 0 61 167 1 1
    PLEKHM1 NUCKS1 0 0 203 208 1 1
    PLEKHM1 NBR1 0 0 468 520 1 2
    PLEKHM1 VPS11 0 0 368 465 1 2
    PLEKHM1 PAFAH1B1 0 0 428 428 1 1
    PLEKHM1 RGPD6 0 0 0 153 1 1
    PLEKHM1 MLX 0 0 0 207 1 1
    PLEKHM1 RGPD1 0 0 0 153 1 1
    PLEKHM1 PLXDC2 0 0 0 177 1 1
    PLEKHM1 VMP1 0 0 207 207 1 2
    PLEKHM1 MTMR4 0 0 140 236 1 1
    PLEKHM1 AP2M1 0 0 108 163 1 1
    PLEKHM1 PPIAL4B 0 0 0 162 1 1
    PLEKHM1 SLC30A5 0 0 113 241 1 1
    PLEKHM1 SPPL2B 0 0 142 230 1 1
    PLEKHM1 TMEM163 0 0 123 157 1 1
    PLEKHM1 CRTAP 0 0 171 221 1 1
    PLEKHM1 SLC22A31 0 0 217 257 1 1
    PLEKHM1 CTSO 0 0 0 347 1 1
    PLEKHM1 CCZ1B 0 0 284 475 1 1
    PLEKHM1 LRRC74B 0 0 194 194 1 1
    PLEKHM1 ZBTB46 0 0 0 171 1 1
    PLEKHM1 PINK1 0 0 261 261 1 2
    PLEKHM1 TMEM51 0 0 202 213 1 1
    PLEKHM1 PIKFYVE 0 0 103 214 1 1
    PLEKHM1 RABGEF1 0 0 146 252 1 1
    PLEKHM1 ACCSL 0 0 213 213 1 1
    PLEKHM1 ATG3 0 0 376 376 1 2
    PLEKHM1 ARHGAP27 0 0 517 582 1 1
    PLEKHM1 KBTBD7 0 0 180 235 1 1
    PLEKHM1 RILPL1 0 0 54 199 1 1
    PLEKHM1 RTN3 0 0 217 217 1 1
    PLEKHM1 SHISA5 0 0 140 159 1 1
    PLEKHM1 EEA1 0 0 217 217 1 1
    PLEKHM1 TNFSF11 0 0 377 377 1 1
    PLEKHM1 AP3M1 0 0 181 186 1 1
    PLEKHM1 KIF5B 0 0 150 159 1 1
    PLEKHM1 FMNL1 0 0 170 201 1 1
    PLEKHM1 BRAP 0 0 107 474 1 1
    PLEKHM1 ATG4C 0 0 158 178 1 2
    PLEKHM1 LRP8 0 0 113 168 1 1
    PLEKHM1 CLCN7 0 0 681 689 1 1
    PLEKHM1 BNIP3L 0 0 325 332 1 2
    PLEKHM1 TAF5L 0 0 134 240 1 1
    PLEKHM1 VAMP7 0 0 401 534 1 1
    PLEKHM1 RAB7B 0 0 806 828 1 1
    PLEKHM1 KBTBD6 0 0 407 444 1 1
    PLEKHM1 MRPS2 0 0 63 312 1 1
    PLEKHM1 RIPK3 0 0 92 162 1 1
    PLEKHM1 ZFYVE1 0 0 270 270 1 2
    PLEKHM1 MPDU1 0 0 171 687 1 1
    PLEKHM1 NRBF2 0 0 210 210 1 2
    PLEKHM1 TBK1 0 0 202 204 1 2
    PLEKHM1 LRRK1 0 0 141 226 1 1
    PLEKHM1 STX17 0 0 657 673 1 2
    PLEKHM1 PTPRQ 0 0 0 213 1 1
    PLEKHM1 CCZ1 0 0 286 476 1 1
    PLEKHM1 DISP2 0 0 193 193 1 1
    PLEKHM1 PRPF40B 0 0 0 158 1 1
    PLEKHM1 TFEB 0 0 201 231 1 2
    PLEKHM1 HPGDS 0 0 457 457 1 1
    PLEKHM1 LRRC37A 0 0 323 323 1 1
    PLEKHM1 RGPD2 0 0 0 153 1 1
    PLEKHM1 IGSF10 0 0 135 292 1 1
    PLEKHM1 BNIP3 0 0 212 212 1 2
    PLEKHM1 SQSTM1 0 0 391 448 1 2
    PLEKHM1 ATG13 0 0 336 336 1 2
    PLEKHM1 SNX10 0 0 651 741 1 2
    PLEKHM1 AP3B2 0 0 145 168 1 1
    PLEKHM1 DEF8 270 0 676 424 1 1
    PLEKHM1 N4BP1 0 0 139 161 1 1
    PLEKHM1 PPIAL4C 0 0 0 162 1 1
    PLEKHM1 ATG9A 0 0 205 233 1 2
    PLEKHM1 CPNE1 0 0 123 177 1 1
    PLEKHM1 GABARAPL1 0 0 626 631 1 2
    PLEKHM1 VPS16 0 0 466 515 1 1
    PLEKHM1 C7orf43 0 0 0 248 1 1
    PLEKHM1 SOST 0 0 166 165 1 1
    PLEKHM1 TMEM175 0 0 181 222 1 1
    PLEKHM1 DCSTAMP 0 0 95 250 1 1
    PLEKHM1 RILP 0 0 404 441 1 1
    PLEKHM1 PM20D1 0 0 242 263 1 1
    PLEKHM1 NCOA4 0 0 134 156 1 1
    PLEKHM1 AIP 0 0 0 248 1 1
    PLEKHM1 LAMP2 0 0 194 204 1 2
    PLEKHM1 PRPF40A 0 0 0 158 1 1
    PLEKHM1 TREM2 0 0 60 206 1 1
    PLEKHM1 TCIRG1 0 0 653 672 1 1
    PLEKHM1 RASD1 0 0 195 195 1 1
    PLEKHM1 FUNDC1 0 0 393 415 1 2
    PLEKHM1 ADAM8 0 0 0 153 1 1
    PLEKHM1 MFN1 0 0 105 173 1 1
    PLEKHM1 ZFYVE27 0 0 243 292 1 1
    PLEKHM1 DGKQ 0 0 218 321 1 1
    PLEKHM1 ULK2 0 0 267 278 1 2
    PLEKHM1 ARL17B 0 0 407 418 1 1
    PLEKHM1 PHF12 0 0 0 174 1 1
    PLEKHM1 GORASP2 0 0 90 204 1 1
    PLEKHM1 MEF2BNB 0 0 136 226 1 1
    PLEKHM1 SNCA 0 0 180 179 1 2
    PLEKHM1 SNAP29 0 0 652 684 1 2
    PLEKHM1 YKT6 0 0 310 325 1 1
    PLEKHM1 RTFDC1 0 0 0 158 1 1
    PLEKHM1 TEX264 0 0 339 355 1 2
    PLEKHM1 MGRN1 0 0 128 215 1 1
    PLEKHM1 LOH12CR1 0 0 232 312 1 1
    PLEKHM1 AMFR 0 0 162 161 1 1
    PLEKHM1 HEXIM2 0 0 212 212 1 1
    PLEKHM1 TBC1D5 0 0 365 371 1 2
    PLEKHM1 C1QL1 0 0 242 241 1 1
    PLEKHM1 RPTOR 0 0 92 266 1 2
    PLEKHM1 GNPAT 0 0 107 201 1 1
    PLEKHM1 CRHR1 0 0 294 294 1 1
    PLEKHM1 IQSEC3 0 0 167 190 1 1
    PLEKHM1 GAK 0 0 181 187 1 1
    PLEKHM1 GCC2 0 0 0 153 1 1
    PLEKHM1 RUSC2 0 0 181 198 1 1
    PLEKHM1 TRAF6 0 0 75 215 1 2
    PLEKHM1 PPIAL4G 0 0 0 162 1 1
    PLEKHM1 TBC1D15 0 0 290 305 1 1
    PLEKHM1 FNBP1 0 0 0 159 1 1
    PLEKHM1 ATG4A 0 0 193 212 1 2
    PLEKHM1 VPS33A 0 0 468 504 1 1
    PLEKHM1 CD79B 0 0 81 252 1 1
    PLEKHM1 GNPTAB 0 0 180 373 1 1
    PLEKHM1 C2orf73 0 0 112 342 1 1
    PLEKHM1 USP24 0 0 134 205 1 1
    PLEKHM1 TRAPPC10 0 0 181 181 1 1
    PLEKHM1 RUSC1 0 0 320 333 1 1
    PLEKHM1 VPS18 0 0 334 474 1 1
    PLEKHM1 DCTN1 0 0 125 178 1 1
    PLEKHM1 PIK3AP1 0 0 0 159 1 1
    PLEKHM1 SPPL2C 0 0 294 299 1 1
    PLEKHM1 MAP1LC3C 800 0 665 931 1 2
    PLEKHM1 PPIAL4F 0 0 0 162 1 1
    PLEKHM1 DNM2 0 0 57 153 1 1
    PLEKHM1 TBC1D2 0 0 325 435 1 1
    PLEKHM1 WAC 0 0 195 530 1 1
    PLEKHM1 HES7 0 0 93 339 1 1
    PLEKHM1 RAB9B 0 0 0 151 1 1
    PLEKHM1 MAPKAPK2 0 0 109 400 1 1
    PLEKHM1 PIP5K1C 0 0 120 166 1 1
    PLEKHM1 ARL17A 0 0 426 437 1 1
    PLEKHM1 ENSG00000279782 0 0 0 162 1 1
    PLEKHM1 RAP1B 270 0 56 281 1 1
    PLEKHM1 PDGFRB 0 0 0 195 1 1
    PLEKHM1 LGALS8 0 0 181 181 1 1
    PLEKHM1 VPS8 0 0 135 287 1 1
    PLEKHM1 RCAN3 0 0 150 168 1 1
    PLEKHM1 OSBPL2 0 0 150 185 1 1
    PLEKHM1 RAB9A 0 0 61 168 1 2
    PLEKHM1 CD300C 0 0 556 565 1 1
    PLEKHM1 MCOLN1 0 0 134 169 1 1
    PLEKHM1 ANKH 0 0 184 183 1 1
    PLEKHM1 TRIM23 0 0 0 154 1 1
    PLEKHM1 SGSM3 0 0 134 196 1 1
    PLEKHM1 XKR6 0 0 243 242 1 1
    PLEKHM1 KIF18B 0 0 218 218 1 1
    PLEKHM1 SNX22 0 0 123 212 1 1
    PLEKHM1 VAMP8 0 0 556 559 1 2
    PLEKHM1 CCDC166 0 0 0 248 1 1
    PLEKHM1 SUMF1 0 0 108 263 1 1
    PLEKHM1 MAP3K7 270 0 48 275 1 1
    PLEKHM1 MED13 0 0 203 428 1 1
    PLEKHM1 DUOXA2 0 0 90 172 1 1
    PLEKHM1 DENND4C 0 0 165 190 1 1
    PLEKHM1 RBPMS2 0 0 159 158 1 1
    PLEKHM1 LAMP1 0 0 325 338 1 2
    PLEKHM1 RAB2A 0 0 260 273 1 1
    PLEKHM1 PLEKHG7 0 0 318 322 1 1
    PLEKHM1 VASP 0 0 90 178 1 1
    PLEKHM1 TOP2A 0 0 0 181 1 1
    PLEKHM1 PPIF 0 0 0 162 1 1
    PLEKHM1 MTMR2 0 0 49 161 1 1
    PLEKHM1 MILR1 0 0 183 183 1 1
    PLEKHM1 RB1CC1 0 0 378 378 1 2
    PLEKHM1 TAX1BP1 0 0 359 359 1 2
    PLEKHM1 VPS39 0 0 543 697 1 1
    PLEKHM1 HDAC5 0 0 57 150 1 1
    PLEKHM1 LRP5 0 0 193 248 1 1
    PLEKHM1 MKNK2 0 0 0 154 1 1
    PLEKHM1 KIFC1 270 0 0 270 1 1
    PLEKHM1 SEC14L4 0 0 181 181 1 1
    PLEKHM1 FAM174A 0 0 91 159 1 1
    PLEKHM1 ACP5 0 0 150 168 1 1
    PLEKHM1 SYT11 0 0 120 164 1 1
    PLEKHM1 VAPA 0 0 306 356 1 1
    PLEKHM1 NPC1 0 0 107 181 1 2
    PLEKHM1 MED21 0 0 45 260 1 1
    PLEKHM1 TREM1 0 0 45 175 1 1
    PLEKHM1 ADRBK2 0 0 90 158 1 1
    PLEKHM1 PARK2 0 0 204 204 1 1
    PLEKHM1 RGPD5 0 0 0 153 1 1
    PLEKHM1 ARL8B 0 0 843 843 1 1
    PLEKHM1 IRGM 0 0 219 236 1 2
    PLEKHM1 NF1 0 0 0 191 1 1
    PLEKHM1 FKBP8 0 0 194 214 1 1
    PLEKHM1 ARL5B 0 0 597 665 1 1
    PLEKHM1 GABARAPL2 0 0 610 635 1 2
    PLEKHM1 ATG14 0 0 469 476 1 2
    PLEKHM1 ATPAF1 0 0 162 168 1 1
    PLEKHM1 PLSCR4 0 0 193 248 1 1
    PLEKHM1 RAB40AL 0 0 108 345 1 1
    PLEKHM1 FYCO1 0 0 603 635 1 2
    PLEKHM1 TOM1 0 0 96 253 1 1
    PLEKHM1 PIK3R4 0 0 341 355 1 2
    PLEKHM1 CLNK 0 0 120 351 1 1
    PLEKHM1 CA2 0 0 630 634 1 1
    PLEKHM1 OSBPL1A 0 0 203 284 1 1
    PLEKHM1 ZKSCAN3 0 0 141 154 1 2
    PLEKHM1 RANBP2 0 0 0 266 1 1
    PLEKHM1 DMRT3 0 0 97 169 1 1
    PLEKHM1 MAP1LC3B2 0 0 0 252 1 2
    PLEKHM1 STARD3NL 0 0 108 163 1 1
    PLEKHM1 CLTCL1 0 0 135 206 1 1
    PLEKHM1 ZNF71 0 0 208 220 1 1
    PLEKHM1 ARF1 0 0 117 194 1 1
    PLEKHM1 PLEK 0 0 556 571 1 1
    PLEKHM1 LYPD3 0 0 157 156 1 1
    PLEKHM1 PIK3C3 0 0 416 420 1 2
    PLEKHM1 SEC24D 0 0 155 162 1 1
    PLEKHM1 GIMAP6 0 0 141 272 1 1
    PLEKHM1 ADAR 0 0 66 161 1 1
    PLEKHM1 MTOR 0 0 218 235 1 2
    PLEKHM1 SYT7 0 0 113 191 1 1
    PLEKHM1 SPNS1 0 0 134 153 1 2
    PLEKHM1 FIGNL1 0 0 150 181 1 1
    PLEKHM1 PACS2 0 0 134 152 1 1
    PLEKHM1 IGSF23 0 0 268 467 1 1
    PLEKHM1 IGSF9B 0 0 174 267 1 1
    PLEKHM1 TGFBRAP1 0 0 107 303 1 1
    PLEKHM1 NMT1 0 0 219 232 1 1
    PLEKHM1 MFN2 0 0 120 268 1 2
    PLEKHM1 ARL8A 0 0 491 491 1 1
    PLEKHM1 ATP6V1B1 0 0 396 396 1 1
    PLEKHM1 OSTM1 0 0 721 726 1 1
    PLEKHM1 MAP1LC3A 0 0 436 444 1 2
    PLEKHM1 ASPA 0 0 83 584 1 1
    PLEKHM1 KIAA1429 270 0 0 270 1 1
    PLEKHM1 SGSM2 0 0 141 173 1 1
    PLEKHM1 SMPD3 0 0 0 151 1 1
    PLEKHM1 RAB5A 0 0 260 289 1 2
    PLEKHM1 VAV3 0 0 83 348 1 1
    PLEKHM1 PPIAL4H 0 0 0 162 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0008270 Molecular Function zinc ion binding enables IEA
    GO:0061909 Biological Process autophagosome-lysosome fusion involved_in IMP
    GO:1902774 Biological Process late endosome to lysosome transport involved_in IMP
    GO:0032418 Biological Process lysosome localization involved_in IDA
    GO:0032418 Biological Process lysosome localization involved_in ISS
    GO:0045780 Biological Process positive regulation of bone resorption involved_in ISS
    GO:1900029 Biological Process positive regulation of ruffle assembly involved_in ISS
    GO:0015031 Biological Process protein transport involved_in IEA
    GO:0044754 Cellular Component autolysosome located_in IDA
    GO:0120281 Cellular Component autolysosome membrane located_in IEA
    GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
    GO:0031902 Cellular Component late endosome membrane located_in IEA
    GO:0005764 Cellular Component lysosome located_in IDA
    GO:0005730 Cellular Component nucleolus located_in IDA
    GO:0005654 Cellular Component nucleoplasm located_in IDA
    Pathways
    Name DB ID
    Autosomal recessive osteopetrosis pathways (WP4788) WikiPathways WP4788_r117658
    Clock-controlled autophagy in bone metabolism (WP5205) WikiPathways WP5205_r122560
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_027774 2 miscRNA transcript variant 2 NC_000017 Reference
    NR_027782 2 miscRNA transcript variant 3 NC_000017 Reference
    XM_047437188 1 mRNA transcript variant X8 NC_000017 Reference
    NM_014798 3 mRNA transcript variant 1 NC_000017 Reference
    XM_017025452 2 mRNA transcript variant X2 NC_000017 Reference
    XM_047437190 1 mRNA transcript variant X10 NC_000017 Reference
    XM_017025451 2 mRNA transcript variant X7 NC_000017 Reference
    XM_011525525 1 mRNA transcript variant X1 NC_000017 Reference
    XM_006722201 5 mRNA transcript variant X4 NC_000017 Reference
    XM_047437192 1 mRNA transcript variant X5 NC_000017 Reference
    XM_011525528 3 mRNA transcript variant X6 NC_000017 Reference
    XM_047437189 1 mRNA transcript variant X9 NC_000017 Reference
    XM_047437191 1 mRNA transcript variant X3 NC_000017 Reference
    NM_001352825 2 mRNA transcript variant 4 NC_000017 Reference