KEAP1

kelch like ECH associated protein 1
General Information
Name kelch like ECH associated protein 1
Alias
  • kelch-like ECH-associated protein 1
  • KEAP1 delta C
  • cytosolic inhibitor of Nrf2
  • kelch-like family member 19
  • kelch-like protein 19
Synonyms KIAA0132 MGC10630 MGC1114 MGC20887 MGC4407 MGC9454 INrf2 KLHL19
Gene_family BTB domain containing|Kelch like
organism Homo sapiens
entrez_id 9817
location 19p13.2
transcript_count 2
exon_count 7
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
      Stringdb Kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome; BTB domain containing
      nextProt Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:19489739, PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    KEAP1 BioGRID PALB2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
    KEAP1 BioGRID XPO7 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID RBCK1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID SENP1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID KEAP1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; FRET; Reconstituted Complex
    KEAP1 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; FRET; Reconstituted Complex; Two-hybrid
    KEAP1 BioGRID NFE2L2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-localization; FRET; PCA; Protein-peptide; Proximity Label-MS; Reconstituted Complex; Two-hybrid
    KEAP1 BioGRID SMURF1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID MAP3K7 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID MCM3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex
    KEAP1 BioGRID C9orf72 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-localization; Protein-peptide; Proximity Label-MS; Reconstituted Complex; Two-hybrid
    KEAP1 BioGRID USP25 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    KEAP1 BioGRID KCNA3 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID HAPSTR1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID HUWE1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID UBC GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    KEAP1 BioGRID DDRGK1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    KEAP1 BioGRID HECTD1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID WWTR1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID FXR1 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    KEAP1 BioGRID OTUD1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Proximity Label-MS
    KEAP1 BioGRID MCAM GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID USP17L2 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID PGCKA1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID ANLN GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID TRIM25 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID M GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID KLHL17 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID KLHL5 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID KLHL3 GeneID BioGRID Affinity Capture-MS; Negative Genetic; Two-hybrid
    KEAP1 BioGRID CLEC16A GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CUL4A GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID KLHL12 GeneID BioGRID Negative Genetic; Reconstituted Complex
    KEAP1 BioGRID KLHL1 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID DCAF6 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID KLHL28 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID FAM117B GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    KEAP1 BioGRID DCAF11 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID WDR82 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID DCAF10 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID COP1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID AMBRA1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID ATG16L1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID DCAF4 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID S GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID TLE2 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID RBBP7 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID GNB2 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID WDTC1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID SNRNP40 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID CIAO1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID DEPTOR GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID NFE2L1 GeneID BioGRID Affinity Capture-Western; Protein-peptide; Two-hybrid
    KEAP1 BioGRID GSK3B GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID GSK3A GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID NCF1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID SYVN1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID RB1 GeneID BioGRID Reconstituted Complex
    KEAP1 BioGRID PHF21A GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID RCOR1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID KDM1A GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID STAU1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID HDAC1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID TRERF1 GeneID BioGRID Protein-peptide
    KEAP1 BioGRID KLHL24 GeneID BioGRID Protein-peptide
    KEAP1 BioGRID ATF5 GeneID BioGRID Protein-peptide
    KEAP1 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID C6orf132 GeneID BioGRID Protein-peptide
    KEAP1 BioGRID PTTG1 GeneID BioGRID Protein-peptide
    KEAP1 BioGRID SGCE GeneID BioGRID Protein-peptide
    KEAP1 BioGRID RAF1 GeneID BioGRID Affinity Capture-MS; FRET
    KEAP1 BioGRID PLEC GeneID BioGRID Protein-peptide
    KEAP1 BioGRID PAK1 GeneID BioGRID Protein-peptide
    KEAP1 BioGRID MCC GeneID BioGRID Protein-peptide
    KEAP1 BioGRID CCNF GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    KEAP1 BioGRID LINC00239 GeneID BioGRID Protein-RNA
    KEAP1 BioGRID ERN2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID HSPA8 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID RBX1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    KEAP1 BioGRID USP7 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID GPRC5A GeneID BioGRID Negative Genetic
    KEAP1 BioGRID BRPF1 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID SHBG GeneID BioGRID Negative Genetic
    KEAP1 BioGRID SGTA GeneID BioGRID Negative Genetic
    KEAP1 BioGRID PXN GeneID BioGRID Negative Genetic
    KEAP1 BioGRID PIN1 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID PIK3CA GeneID BioGRID Negative Genetic
    KEAP1 BioGRID PALM GeneID BioGRID Negative Genetic
    KEAP1 BioGRID NUMA1 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID UIMC1 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID G6PC1 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID BPTF GeneID BioGRID Co-localization; Negative Genetic; Reconstituted Complex; Two-hybrid
    KEAP1 BioGRID EZH1 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID DYRK1A GeneID BioGRID Negative Genetic
    KEAP1 BioGRID CTBP2 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID MAPK14 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID BORCS8 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID VGLL3 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID DIPK1A GeneID BioGRID Negative Genetic
    KEAP1 BioGRID HSD11B1L GeneID BioGRID Negative Genetic
    KEAP1 BioGRID STAC2 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID CCDC71L GeneID BioGRID Negative Genetic
    KEAP1 BioGRID USH1G GeneID BioGRID Negative Genetic
    KEAP1 BioGRID CANT1 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID SLC38A10 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID GRIN3B GeneID BioGRID Negative Genetic
    KEAP1 BioGRID MRRF GeneID BioGRID Negative Genetic
    KEAP1 BioGRID FKRP GeneID BioGRID Negative Genetic
    KEAP1 BioGRID ELMO2 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID TMCO6 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID MED9 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID COA3 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID COQ2 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID ATP6V0A2 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID SMCHD1 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID RRAS2 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID TUSC2 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID MED13 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID TBKBP1 GeneID BioGRID Negative Genetic
    KEAP1 BioGRID BTRC GeneID BioGRID Affinity Capture-MS; Proximity Label-MS; Two-hybrid
    KEAP1 BioGRID Nfe2l2 GeneID BioGRID Affinity Capture-Western; Co-localization
    KEAP1 BioGRID PRKN GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID HSP90AA1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    KEAP1 BioGRID BAP1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID PRMT1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID GABPA GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID PTMA GeneID BioGRID Affinity Capture-MS; Co-crystal Structure; Protein-peptide; Reconstituted Complex; Two-hybrid
    KEAP1 BioGRID GSPT1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID EGFR GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Negative Genetic; Positive Genetic
    KEAP1 BioGRID HIF1A GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID NBR1 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS
    KEAP1 BioGRID CALCOCO2 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID TAX1BP1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID MAP1LC3B GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    KEAP1 BioGRID TOLLIP GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID GULP1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID N GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID KLHL2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
    KEAP1 BioGRID PPP1R13L GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    KEAP1 BioGRID P3H3 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID TSPAN5 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID DPP3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
    KEAP1 BioGRID DNAJB8 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID ZC3H18 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID IL17F GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID DPP9 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID TSC22D4 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
    KEAP1 BioGRID NAA40 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID ACD GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID BCL11B GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID MAPK8IP1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID TNFRSF6B GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CDK13 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID DPF1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID ZNF213 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID SP1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID NEU2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CDH5 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID APP GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID FBXL17 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    KEAP1 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    KEAP1 BioGRID CEP135 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID UBE2D1 GeneID BioGRID Reconstituted Complex
    KEAP1 BioGRID SOX9 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID TRIM37 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID NR4A1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CAV1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID FAM20C GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID NOS3 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID GAPDH GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID EP300 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID LAMC1 GeneID BioGRID Protein-peptide
    KEAP1 BioGRID ASTN1 GeneID BioGRID Protein-peptide; Reconstituted Complex
    KEAP1 BioGRID ATRAID GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID Apc2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID PAQR4 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    KEAP1 BioGRID EGLN1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID Rnf183 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID orf3 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID KIF14 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID TAF1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID LDLR GeneID BioGRID Negative Genetic
    KEAP1 BioGRID FASN GeneID BioGRID Negative Genetic
    KEAP1 BioGRID ETF1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS; Two-hybrid
    KEAP1 BioGRID PRKCZ GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID PRKCI GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID PRKCE GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID TET2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    KEAP1 BioGRID NES GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID SLX4 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID OPTN GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID URI1 GeneID BioGRID Affinity Capture-Western; Co-localization
    KEAP1 BioGRID NIBAN2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization; FRET; Two-hybrid
    KEAP1 BioGRID PIDD1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    KEAP1 BioGRID FBXW8 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID LAMTOR5 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    KEAP1 BioGRID NUP50 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID TRIM28 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID ATG5 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID RECK GeneID BioGRID Two-hybrid
    KEAP1 BioGRID ZNF121 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID SMARCD1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID PRKAG1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID C2orf68 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID ERICH5 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID MAD2L1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
    KEAP1 BioGRID ICAM1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID GYPA GeneID BioGRID Two-hybrid
    KEAP1 BioGRID CSNK2A1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID COL2A1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID COL1A1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID GPR151 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID EAF1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID WDR83 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID MCMBP GeneID BioGRID Affinity Capture-Luminescence; Affinity Capture-MS; Two-hybrid
    KEAP1 BioGRID IFIH1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID IQCC GeneID BioGRID Two-hybrid
    KEAP1 BioGRID STAP2 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID NTAQ1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID TBC1D7 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID CARD10 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID LSM3 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID WHRN GeneID BioGRID Two-hybrid
    KEAP1 BioGRID ANKS1A GeneID BioGRID Two-hybrid
    KEAP1 BioGRID BRD7 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CDK6 GeneID BioGRID FRET
    KEAP1 BioGRID ULK1 GeneID BioGRID Affinity Capture-Western; Co-localization
    KEAP1 BioGRID STK4 GeneID BioGRID Affinity Capture-MS; Biochemical Activity
    KEAP1 BioGRID STK3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    KEAP1 BioGRID NHLRC2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    KEAP1 BioGRID NR2C2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID IKBKG GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID CCND1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID IKBKB GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
    KEAP1 BioGRID CHUK GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID EEA1 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID PIK3C3 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID BCL2 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID VCP GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID PSMD4 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID PSMD2 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID E1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID Vcp GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID Cul3 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID PGAM5 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    KEAP1 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CDC34 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID PYHIN1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID EEF2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CASP1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID BRCA2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    KEAP1 BioGRID LAMA1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID EGLN3 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CHD6 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CPEB2 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID COPG1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID NIPSNAP2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID PDCD6IP GeneID BioGRID Affinity Capture-MS; Two-hybrid
    KEAP1 BioGRID WDR1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    KEAP1 BioGRID SLK GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    KEAP1 BioGRID NPM1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID SNRPN GeneID BioGRID Affinity Capture-MS; Two-hybrid
    KEAP1 BioGRID MCM2 GeneID BioGRID Affinity Capture-Western; Co-localization
    KEAP1 BioGRID HSP90AB1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
    KEAP1 BioGRID SASS6 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID PFAS GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID ARCN1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID PSMD10 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID ATG42 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID GLK1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID CDK20 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    KEAP1 BioGRID CTTN GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    KEAP1 BioGRID UBE2A GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID RAD51 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID BRCA1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID Palb2 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID FBXW11 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID SYNE4 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID SSH3 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CDH1 GeneID BioGRID Affinity Capture-Western; Proximity Label-MS; Reconstituted Complex
    KEAP1 BioGRID USP15 GeneID BioGRID Biochemical Activity
    KEAP1 BioGRID PAQR3 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID RBM45 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    KEAP1 BioGRID TRIM15 GeneID BioGRID PCA
    KEAP1 BioGRID TUBG1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID POLR2F GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID GAR1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID MED4 GeneID BioGRID Proximity Label-MS
    KEAP1 BioGRID BAG3 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID Sesn2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID Bag2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID Isy1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID Ppp2ca GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID Prkci GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID Cd2ap GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID BOD1L1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID MYH7 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID CCNB1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID NAF1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID FERMT3 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID POLR3E GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID MLST8 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID OXR1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID ZSCAN32 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID MAPKBP1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID NUDT4 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID CCNB1IP1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID AMER1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    KEAP1 BioGRID GPRASP2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID RELA GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    KEAP1 BioGRID CLU GeneID BioGRID Two-hybrid
    KEAP1 BioGRID CAT GeneID BioGRID Two-hybrid
    KEAP1 BioGRID BAD GeneID BioGRID Two-hybrid
    KEAP1 BioGRID TENT5A GeneID BioGRID Two-hybrid
    KEAP1 BioGRID GLRX5 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID DDIT3 GeneID BioGRID Co-fractionation
    KEAP1 BioGRID SESN2 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID SESN1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID TSC22D2 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID ENC1 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID TERF1 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID NEIL2 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID IPO11 GeneID BioGRID Reconstituted Complex
    KEAP1 BioGRID KPNA6 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    KEAP1 BioGRID IRF1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    KEAP1 BioGRID AK4 GeneID BioGRID Two-hybrid
    KEAP1 BioGRID CUL2 GeneID BioGRID Affinity Capture-Western
    KEAP1 BioGRID GABARAPL1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID GABARAPL2 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID GABARAP GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID USP11 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    KEAP1 BioGRID OSBPL10 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID TMEM160 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID GET4 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID VWA8 GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID MAZ GeneID BioGRID Affinity Capture-MS
    KEAP1 BioGRID BBS1 GeneID BioGRID Affinity Capture-MS
    KEAP1 Protein TENT5A GeneID HPRD None
    KEAP1 Protein BPTF GeneID HPRD None
    KEAP1 Protein NFE2L2 GeneID HPRD None
    KEAP1 Protein ETF1 GeneID HPRD None
    KEAP1 Protein MYO7A GeneID HPRD None
    KEAP1 BioGRID MYO7A GeneID BioGRID Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    KEAP1 GLUL 0 0 216 233 1 1
    KEAP1 DDB1 0 0 241 331 1 1
    KEAP1 VDAC1 0 0 310 309 1 2
    KEAP1 TGFB1 0 0 195 245 1 1
    KEAP1 RIPK3 0 0 172 228 1 1
    KEAP1 GSTA3 0 0 322 368 1 1
    KEAP1 PRKCD 0 0 678 678 1 2
    KEAP1 GSTZ1 0 0 205 205 1 1
    KEAP1 CYP2D6 0 0 108 227 1 1
    KEAP1 DCAF11 0 0 503 592 1 1
    KEAP1 MGST1 0 0 214 228 1 1
    KEAP1 TBK1 0 0 244 260 1 2
    KEAP1 CYP4V2 0 0 0 220 1 1
    KEAP1 FGA 0 0 49 166 1 1
    KEAP1 RAC2 0 0 140 167 1 1
    KEAP1 SKP1 800 0 392 874 1 1
    KEAP1 KDR 0 0 208 208 1 2
    KEAP1 CDKN3 0 0 193 208 1 1
    KEAP1 TRIM28 270 0 44 299 1 2
    KEAP1 BIRC6 0 0 0 195 1 1
    KEAP1 HARS2 0 0 286 311 1 1
    KEAP1 DNAJB1 0 0 181 198 1 2
    KEAP1 ATG3 0 0 293 312 1 2
    KEAP1 DAO 0 0 181 181 1 1
    KEAP1 HNF4A 0 0 202 205 1 1
    KEAP1 COMT 0 0 177 183 1 1
    KEAP1 TERF2IP 0 0 42 154 1 1
    KEAP1 SRXN1 0 0 607 626 1 1
    KEAP1 TP53INP1 0 0 167 167 1 2
    KEAP1 TNFSF11 0 0 180 179 1 1
    KEAP1 APOE 0 0 235 235 1 1
    KEAP1 SLC2A4 0 0 210 227 1 1
    KEAP1 VDAC3 0 0 150 156 1 1
    KEAP1 FOXO3 0 0 391 495 1 2
    KEAP1 TFCP2 0 0 0 206 1 1
    KEAP1 GPX6 0 0 133 410 1 1
    KEAP1 CYP2J2 0 0 81 203 1 1
    KEAP1 KLHL33 0 0 0 162 1 1
    KEAP1 SQRDL 0 0 243 242 1 1
    KEAP1 GSTA2 0 0 460 497 1 1
    KEAP1 AIFM1 0 0 150 236 1 1
    KEAP1 FBN1 0 0 0 201 1 1
    KEAP1 NGF 0 0 218 218 1 1
    KEAP1 PSMC1 0 0 144 301 1 1
    KEAP1 NEIL3 0 0 60 419 1 1
    KEAP1 TH 0 0 232 271 1 1
    KEAP1 SEPP1 0 0 142 235 1 1
    KEAP1 GPT 0 0 392 392 1 1
    KEAP1 PHGDH 0 0 285 314 1 1
    KEAP1 PINK1 0 0 400 535 1 2
    KEAP1 SPTA1 0 0 112 402 1 1
    KEAP1 TCEB2 0 0 150 151 1 1
    KEAP1 MYH4 0 0 0 258 1 1
    KEAP1 FOXO4 0 0 175 193 1 1
    KEAP1 HSP90AB1 270 0 74 540 1 2
    KEAP1 EIF4EBP1 0 0 212 212 1 1
    KEAP1 ADRM1 0 0 107 169 1 1
    KEAP1 ENSG00000279392 0 0 92 193 1 1
    KEAP1 DUOX1 0 0 382 392 1 1
    KEAP1 NOX4 0 0 556 566 1 1
    KEAP1 SDHD 0 0 137 177 1 1
    KEAP1 PARL 0 0 155 154 1 1
    KEAP1 KMT2D 0 0 404 419 1 1
    KEAP1 GGT1 0 0 171 190 1 1
    KEAP1 CSF2 0 0 155 154 1 1
    KEAP1 FBN2 0 0 0 386 1 1
    KEAP1 UGT1A1 0 0 394 431 1 1
    KEAP1 ISCU 0 0 113 192 1 1
    KEAP1 VCAM1 0 0 295 320 1 1
    KEAP1 UQCRFS1 0 0 94 174 1 1
    KEAP1 VCL 0 0 197 197 1 1
    KEAP1 GLS2 0 0 218 226 1 1
    KEAP1 CBSL 0 0 335 375 1 1
    KEAP1 MT2A 0 0 181 195 1 1
    KEAP1 IGBP1 0 0 0 175 1 1
    KEAP1 ASCL4 0 0 170 169 1 1
    KEAP1 DCUN1D3 0 0 134 160 1 1
    KEAP1 XDH 0 0 145 377 1 1
    KEAP1 UGT1A4 0 0 66 170 1 1
    KEAP1 CD44 0 0 161 161 1 1
    KEAP1 SLC1A5 0 0 157 156 1 1
    KEAP1 BDNF 0 0 253 252 1 2
    KEAP1 USP5 0 0 81 156 1 1
    KEAP1 UCP3 0 0 202 205 1 1
    KEAP1 CASP2 0 0 142 194 1 1
    KEAP1 PKM 0 0 265 265 1 1
    KEAP1 GADD45A 0 0 165 165 1 1
    KEAP1 GSTM5 0 0 167 251 1 1
    KEAP1 MAPK1 0 0 242 306 1 2
    KEAP1 PPP2R1A 0 0 156 195 1 1
    KEAP1 IGF1 0 0 266 283 1 1
    KEAP1 APOB 0 0 193 193 1 1
    KEAP1 WDFY3 0 0 138 177 1 2
    KEAP1 SUV39H2 0 0 55 191 1 1
    KEAP1 LIMD2 0 0 0 164 1 1
    KEAP1 SYNE4 213 0 0 213 1 1
    KEAP1 PRDX2 0 0 294 484 1 1
    KEAP1 CUL4B 0 0 211 377 1 1
    KEAP1 SOS1 0 0 60 157 1 1
    KEAP1 IREB2 0 0 233 249 1 1
    KEAP1 PRDX4 0 0 265 324 1 1
    KEAP1 FGF2 0 0 171 171 1 1
    KEAP1 NFE2L3 0 0 556 617 1 1
    KEAP1 RELB 0 0 201 220 1 2
    KEAP1 MTHFD2L 0 0 71 181 1 1
    KEAP1 NCF1 0 0 325 325 1 1
    KEAP1 GGTLC1 0 0 164 183 1 1
    KEAP1 SLC35A2 0 0 377 390 1 1
    KEAP1 PRKAA1 0 0 96 164 1 2
    KEAP1 DCUN1D4 0 600 74 617 1 1
    KEAP1 CCND1 130 0 405 464 1 1
    KEAP1 TACC3 0 0 166 169 1 1
    KEAP1 NOS3 0 0 565 571 1 1
    KEAP1 JUND 0 0 261 261 1 1
    KEAP1 KLHL25 0 900 95 901 1 1
    KEAP1 RNF170 0 0 0 187 1 1
    KEAP1 MCMBP 458 0 150 554 1 1
    KEAP1 CCNB1IP1 500 0 0 499 1 1
    KEAP1 PRKDC 0 0 107 153 1 2
    KEAP1 SLPI 0 0 141 164 1 1
    KEAP1 GSTA1 0 0 517 550 1 1
    KEAP1 HMGCR 0 0 112 173 1 1
    KEAP1 NOX5 0 0 242 373 1 1
    KEAP1 FAM46A 72 0 0 228 1 1
    KEAP1 CCNE1 0 0 193 218 1 1
    KEAP1 FH 0 0 563 563 1 1
    KEAP1 TXN 0 0 688 717 1 1
    KEAP1 ENSG00000264813 0 0 384 384 1 1
    KEAP1 AOX1 0 0 158 210 1 1
    KEAP1 GCH1 0 0 123 158 1 1
    KEAP1 PECAM1 0 0 157 156 1 1
    KEAP1 UBB 0 600 61 622 1 1
    KEAP1 CYP4F22 0 0 0 227 1 1
    KEAP1 LPCAT3 0 0 113 162 1 1
    KEAP1 LDLR 68 0 149 192 1 1
    KEAP1 KLF9 0 0 143 198 1 1
    KEAP1 RHEB 0 0 182 209 1 2
    KEAP1 ADD1 0 0 0 157 1 1
    KEAP1 AKR1C1 0 0 517 523 1 1
    KEAP1 LEP 0 0 233 234 1 1
    KEAP1 RHOT2 0 0 150 222 1 1
    KEAP1 NFKBIA 0 0 470 502 1 1
    KEAP1 C12orf5 0 0 241 240 1 1
    KEAP1 KLHL22 0 900 213 906 1 1
    KEAP1 MAP3K3 0 0 241 240 1 1
    KEAP1 SREBF1 0 0 324 349 1 2
    KEAP1 UCP1 0 0 136 154 1 1
    KEAP1 UBA52 0 600 0 608 1 1
    KEAP1 AKR7A2 0 0 294 299 1 1
    KEAP1 LMNB2 0 0 74 178 1 1
    KEAP1 MAPK14 0 0 271 644 1 1
    KEAP1 WDR1 270 0 459 588 1 1
    KEAP1 CFL1 0 0 90 229 1 1
    KEAP1 PTEN 0 0 556 596 1 2
    KEAP1 TXN2 0 0 282 301 1 1
    KEAP1 TNFAIP1 0 900 0 900 1 1
    KEAP1 GABARAP 350 0 243 683 1 2
    KEAP1 MAPK7 0 0 181 241 1 1
    KEAP1 KDM5C 0 0 151 186 1 1
    KEAP1 NFIA 0 0 0 261 1 1
    KEAP1 ARID2 0 0 366 371 1 1
    KEAP1 VEGFA 0 0 402 402 1 1
    KEAP1 DET1 0 0 107 187 1 1
    KEAP1 SLC7A7 0 0 0 245 1 1
    KEAP1 DNM1L 0 0 324 364 1 2
    KEAP1 WIPI1 0 0 140 165 1 2
    KEAP1 ACTG1 0 0 206 235 1 1
    KEAP1 ZNF750 0 0 182 181 1 1
    KEAP1 ATG7 0 0 589 683 1 2
    KEAP1 KIAA1210 0 0 119 211 1 1
    KEAP1 TJP1 0 0 242 241 1 1
    KEAP1 SELE 0 0 161 171 1 1
    KEAP1 EGLN2 0 0 178 247 1 1
    KEAP1 PTGR1 0 0 265 265 1 1
    KEAP1 COL1A1 232 0 113 305 1 1
    KEAP1 CYP4F8 0 0 0 229 1 1
    KEAP1 NAMPT 0 0 138 325 1 1
    KEAP1 PPARGC1B 0 0 154 206 1 1
    KEAP1 CCL20 0 0 54 153 1 1
    KEAP1 PSMB7 0 0 124 169 1 1
    KEAP1 GFAP 0 0 167 185 1 2
    KEAP1 POLE2 0 0 0 173 1 1
    KEAP1 SHC1 0 0 108 163 1 1
    KEAP1 ATM 0 0 391 404 1 1
    KEAP1 AXIN1 0 0 232 249 1 1
    KEAP1 CTSD 0 0 135 176 1 2
    KEAP1 IDH2 0 0 282 310 1 1
    KEAP1 KLHL3 616 900 460 964 1 1
    KEAP1 CDH10 0 0 71 378 1 1
    KEAP1 ALDH1B1 0 0 108 166 1 1
    KEAP1 COMMD6 0 600 0 600 1 1
    KEAP1 TXNDC17 0 0 253 266 1 1
    KEAP1 G6PD 0 0 497 568 1 1
    KEAP1 RAD23B 0 0 93 226 1 1
    KEAP1 RET 0 0 264 264 1 1
    KEAP1 ZC3H18 130 0 0 165 1 1
    KEAP1 DCUN1D2 0 600 134 642 1 1
    KEAP1 SOD3 0 0 325 339 1 1
    KEAP1 KCTD13 0 900 0 900 1 1
    KEAP1 GPX3 0 0 390 585 1 1
    KEAP1 AKT3 0 0 150 315 1 1
    KEAP1 OSBPL9 0 0 0 169 1 1
    KEAP1 DDX11 0 0 46 185 1 1
    KEAP1 IKBKG 486 0 209 593 1 1
    KEAP1 RARA 0 0 207 219 1 1
    KEAP1 GPX1 0 0 608 716 1 1
    KEAP1 KDM5B 0 0 92 199 1 1
    KEAP1 PSMD14 0 0 166 242 1 1
    KEAP1 HSPB2 0 0 189 201 1 1
    KEAP1 HSPB1 0 0 218 235 1 1
    KEAP1 TGFBR1 0 500 82 521 1 1
    KEAP1 ATG10 0 0 235 235 1 2
    KEAP1 ARID1A 0 0 451 457 1 1
    KEAP1 SMG6 0 0 0 179 1 1
    KEAP1 NFKBIB 0 0 137 250 1 1
    KEAP1 KPTN 0 0 0 242 1 1
    KEAP1 PIAS3 0 0 0 171 1 1
    KEAP1 MT-ND1 0 0 63 265 1 1
    KEAP1 ATG5 153 0 468 587 1 2
    KEAP1 PTPN1 0 0 387 386 1 1
    KEAP1 XBP1 0 0 304 304 1 2
    KEAP1 GYPA 468 0 0 468 1 1
    KEAP1 COMMD4 0 600 0 627 1 1
    KEAP1 TP63 0 0 391 405 1 2
    KEAP1 GIT1 0 0 0 157 1 1
    KEAP1 MCL1 0 0 283 282 1 2
    KEAP1 RBM10 0 0 387 417 1 1
    KEAP1 SMARCA4 0 0 338 357 1 1
    KEAP1 SIRT1 0 0 520 580 1 2
    KEAP1 TP53BP1 0 0 207 210 1 1
    KEAP1 NOX1 0 0 412 422 1 1
    KEAP1 CTSB 0 0 183 194 1 2
    KEAP1 DUOX2 0 0 289 301 1 1
    KEAP1 HMGB1 0 0 241 257 1 2
    KEAP1 COPS5 0 0 173 225 1 1
    KEAP1 BACE1 0 0 122 187 1 1
    KEAP1 KLHDC8B 0 0 0 205 1 1
    KEAP1 ITGAM 0 0 150 168 1 1
    KEAP1 MAP3K5 0 0 460 493 1 1
    KEAP1 PSMC5 0 0 0 161 1 1
    KEAP1 LZTR1 0 900 157 906 1 1
    KEAP1 CCDC22 0 600 0 605 1 1
    KEAP1 LRRK2 0 0 167 212 1 2
    KEAP1 MET 0 0 181 181 1 1
    KEAP1 PMAIP1 0 0 251 250 1 1
    KEAP1 TLR2 0 0 156 155 1 1
    KEAP1 CDKN2B 0 0 167 185 1 1
    KEAP1 WEE1 0 0 150 157 1 1
    KEAP1 ALDH1A1 0 0 174 217 1 1
    KEAP1 SF3B3 0 0 74 169 1 1
    KEAP1 MAOB 0 0 181 198 1 1
    KEAP1 TFCP2L1 0 0 0 206 1 1
    KEAP1 UBE2E3 0 0 183 301 1 1
    KEAP1 GSS 0 0 56 213 1 1
    KEAP1 GSTM2 0 0 381 476 1 1
    KEAP1 PTPN11 0 0 154 164 1 1
    KEAP1 OSBPL11 0 0 0 177 1 1
    KEAP1 IRG1 0 0 241 263 1 1
    KEAP1 U2AFBP 0 0 218 235 1 1
    KEAP1 AKAP8 0 0 66 278 1 1
    KEAP1 TNNI1 0 0 0 150 1 1
    KEAP1 FOS 0 0 358 358 1 1
    KEAP1 TWIST1 0 0 141 153 1 1
    KEAP1 CBX7 0 0 0 159 1 1
    KEAP1 YWHAZ 0 0 99 152 1 1
    KEAP1 SOD2 0 0 556 633 1 1
    KEAP1 GPX2 0 0 596 720 1 1
    KEAP1 EPAS1 0 0 82 195 1 2
    KEAP1 FOXO1 0 0 321 321 1 2
    KEAP1 PGD 0 0 322 478 1 1
    KEAP1 FTH1 0 0 391 420 1 1
    KEAP1 BTRC 256 0 569 699 1 1
    KEAP1 GDPD2 0 0 63 216 1 1
    KEAP1 NRAS 0 0 124 175 1 1
    KEAP1 AKR1A1 0 0 147 170 1 1
    KEAP1 HSPA5 0 0 391 429 1 2
    KEAP1 TFE3 0 0 82 164 1 1
    KEAP1 KLF2 0 0 143 159 1 1
    KEAP1 CUL3 981 900 989 999 1 1
    KEAP1 CHUK 486 0 298 654 1 1
    KEAP1 SAMHD1 0 0 0 190 1 1
    KEAP1 MYH1 0 0 61 274 1 1
    KEAP1 PBRM1 0 0 245 259 1 1
    KEAP1 FAM98A 0 0 55 158 1 1
    KEAP1 FABP4 0 0 167 167 1 1
    KEAP1 SPRR2D 0 0 293 293 1 1
    KEAP1 HDAC1 0 0 210 252 1 2
    KEAP1 TFB2M 0 0 113 160 1 1
    KEAP1 POLR1A 0 0 45 166 1 1
    KEAP1 PI4KA 0 0 45 157 1 1
    KEAP1 NQO1 0 0 873 892 1 1
    KEAP1 FGF19 0 0 241 240 1 1
    KEAP1 NFIB 0 0 55 150 1 1
    KEAP1 DAXX 0 0 310 333 1 1
    KEAP1 AFP 0 0 134 188 1 1
    KEAP1 HSPB8 0 0 141 172 1 2
    KEAP1 MYH8 0 0 0 200 1 1
    KEAP1 ENSG00000160201 0 0 218 235 1 1
    KEAP1 ATG4D 0 0 108 171 1 2
    KEAP1 COPS8 0 0 149 164 1 1
    KEAP1 NR2C2 270 0 0 281 1 1
    KEAP1 KLHL20 0 900 460 909 1 1
    KEAP1 PSMC4 0 0 134 150 1 1
    KEAP1 ATG12 0 0 323 378 1 2
    KEAP1 ALOX5 0 0 193 193 1 1
    KEAP1 USP11 131 0 157 306 1 1
    KEAP1 NOTCH2 0 0 180 236 1 1
    KEAP1 MRFAP1 0 0 117 156 1 1
    KEAP1 RHOBTB1 0 800 0 803 1 1
    KEAP1 KCTD5 0 540 91 577 1 1
    KEAP1 POLH 0 0 0 206 1 1
    KEAP1 DDR2 0 0 324 323 1 1
    KEAP1 APP 130 0 274 349 1 1
    KEAP1 MFN2 0 0 310 344 1 2
    KEAP1 EGR1 0 0 150 185 1 1
    KEAP1 DCAF6 0 0 61 192 1 1
    KEAP1 KLHL9 0 900 322 907 1 1
    KEAP1 TRPV1 0 0 194 194 1 1
    KEAP1 CTNNB1 0 0 452 464 1 1
    KEAP1 HRAS 0 0 564 589 1 1
    KEAP1 SLC1A7 0 0 180 179 1 1
    KEAP1 BAI3 0 0 181 181 1 1
    KEAP1 ARF3 0 0 57 335 1 1
    KEAP1 HSPB7 0 0 95 331 1 1
    KEAP1 SUMO2 0 0 134 183 1 1
    KEAP1 CXCL8 0 0 390 390 1 1
    KEAP1 NR1H3 0 0 95 155 1 1
    KEAP1 BAG3 128 0 142 222 1 2
    KEAP1 CYP4F2 0 0 0 233 1 1
    KEAP1 CYP4A11 0 0 0 296 1 1
    KEAP1 SYVN1 0 0 132 191 1 1
    KEAP1 OCLN 0 0 294 294 1 1
    KEAP1 ENDOG 0 0 142 182 1 1
    KEAP1 STAT1 0 0 213 255 1 1
    KEAP1 RAD51C 0 0 145 496 1 1
    KEAP1 CYP2C18 0 0 73 283 1 1
    KEAP1 CYP4A22 0 0 0 296 1 1
    KEAP1 CTRL 0 0 269 269 1 1
    KEAP1 TBL1XR1 0 0 67 150 1 1
    KEAP1 KLHL31 0 0 490 185 1 1
    KEAP1 PIK3C3 270 0 323 569 1 2
    KEAP1 BICC1 0 0 0 168 1 1
    KEAP1 LRRC40 0 0 74 452 1 1
    KEAP1 MTOR 0 0 827 836 1 2
    KEAP1 SUV420H1 0 0 0 185 1 1
    KEAP1 RAD51 270 0 195 500 1 1
    KEAP1 RAD23A 0 0 74 172 1 1
    KEAP1 MMP1 0 0 143 166 1 1
    KEAP1 HSF1 0 0 134 303 1 1
    KEAP1 UGDH 0 0 170 176 1 1
    KEAP1 SIRT2 0 0 376 390 1 2
    KEAP1 LAMTOR5 270 0 74 295 1 1
    KEAP1 KLHL15 0 360 90 386 1 1
    KEAP1 DMRT3 0 0 0 160 1 1
    KEAP1 UGT3A2 0 0 0 175 1 1
    KEAP1 MAP1LC3B2 0 0 61 160 1 2
    KEAP1 COMMD9 0 600 0 608 1 1
    KEAP1 AKR1B10 0 0 413 421 1 1
    KEAP1 CREB1 0 0 340 340 1 1
    KEAP1 KHDRBS1 0 0 447 455 1 1
    KEAP1 NOX3 0 0 162 176 1 1
    KEAP1 GCSH 0 0 143 161 1 1
    KEAP1 RHOBTB2 0 800 69 810 1 1
    KEAP1 CREBBP 0 0 391 459 1 1
    KEAP1 KLHDC7B 0 0 138 152 1 1
    KEAP1 HCAR2 0 0 181 237 1 1
    KEAP1 PFKFB3 0 0 150 185 1 1
    KEAP1 ESRRA 0 0 181 236 1 1
    KEAP1 UBE2D3 0 0 108 215 1 1
    KEAP1 SDHB 0 0 321 335 1 1
    KEAP1 ACO2 0 0 263 308 1 1
    KEAP1 NFE2 0 0 818 844 1 1
    KEAP1 UGT2A3 0 0 0 300 1 1
    KEAP1 ABL1 0 0 193 193 1 1
    KEAP1 MAP2K7 0 0 375 375 1 1
    KEAP1 MOGS 0 0 144 165 1 1
    KEAP1 CYP1A1 0 0 370 457 1 1
    KEAP1 GAPDH 0 0 561 603 1 2
    KEAP1 SLC22A13 0 0 0 269 1 1
    KEAP1 NNT 0 0 124 158 1 1
    KEAP1 FGFR2 0 0 202 202 1 1
    KEAP1 RELA 314 0 808 887 1 1
    KEAP1 NPR1 0 0 74 157 1 1
    KEAP1 FYCO1 0 0 123 235 1 2
    KEAP1 NFKB1 0 0 167 203 1 1
    KEAP1 PLK4 0 0 0 150 1 1
    KEAP1 ART5 0 0 108 587 1 1
    KEAP1 PCLO 0 0 49 439 1 1
    KEAP1 CLDN15 0 0 182 182 1 1
    KEAP1 GSTM3 0 0 304 587 1 1
    KEAP1 IGF2BP2 0 0 0 209 1 1
    KEAP1 ACP5 0 0 134 152 1 1
    KEAP1 KLHL21 0 900 195 904 1 1
    KEAP1 TOP1 0 0 91 158 1 1
    KEAP1 ATRAID 270 0 0 270 1 1
    KEAP1 USP15 270 600 185 803 1 1
    KEAP1 DVL1 0 0 50 204 1 1
    KEAP1 G6PC 0 0 181 181 1 1
    KEAP1 RICTOR 0 0 150 151 1 2
    KEAP1 ENSG00000261832 0 0 57 159 1 1
    KEAP1 P4HB 0 0 270 317 1 2
    KEAP1 GPX7 0 0 181 613 1 1
    KEAP1 PPARGC1A 0 0 467 467 1 1
    KEAP1 PCK1 0 0 66 226 1 1
    KEAP1 BTBD9 0 0 0 154 1 1
    KEAP1 ABCC2 0 0 310 322 1 1
    KEAP1 MAD2L1 748 0 63 763 1 1
    KEAP1 IFNA1 0 0 155 154 1 1
    KEAP1 PARK2 0 0 391 441 1 1
    KEAP1 WNT5A 0 0 95 157 1 1
    KEAP1 PPRC1 0 0 60 154 1 1
    KEAP1 WNK4 0 0 134 295 1 1
    KEAP1 ST13 0 0 111 166 1 2
    KEAP1 BACH1 0 0 468 338 1 1
    KEAP1 POR 0 0 134 181 1 1
    KEAP1 CDKN2D 0 0 536 546 1 1
    KEAP1 BRCA1 270 0 603 700 1 1
    KEAP1 STK11 0 0 563 598 1 2
    KEAP1 RB1CC1 0 0 310 363 1 2
    KEAP1 ACTA1 0 0 90 168 1 1
    KEAP1 XRCC3 0 0 142 310 1 1
    KEAP1 LRP1B 0 0 241 260 1 1
    KEAP1 TTN 0 0 112 214 1 1
    KEAP1 C9orf72 0 0 112 201 1 2
    KEAP1 SLC2A3 0 0 150 168 1 1
    KEAP1 MAP1A 0 0 335 372 1 1
    KEAP1 HDAC2 0 0 266 305 1 1
    KEAP1 SLC7A5 0 0 83 396 1 1
    KEAP1 TRIM15 191 0 0 191 1 1
    KEAP1 CUL2 270 0 325 572 1 1
    KEAP1 NCOR2 0 0 113 197 1 1
    KEAP1 PEF1 0 720 65 738 1 1
    KEAP1 RAF1 278 0 170 403 1 2
    KEAP1 CFLAR 0 0 150 173 1 1
    KEAP1 EGFR 270 0 552 661 1 1
    KEAP1 KANK1 0 0 57 223 1 1
    KEAP1 HTT 0 0 282 326 1 1
    KEAP1 TSC22D4 646 0 159 697 1 1
    KEAP1 FGFR3 0 0 202 202 1 1
    KEAP1 LAMP1 0 0 151 165 1 2
    KEAP1 NEDD8 0 600 315 726 1 1
    KEAP1 SLC2A1 0 0 261 277 1 1
    KEAP1 COMMD8 0 600 0 610 1 1
    KEAP1 MDM2 0 0 391 390 1 1
    KEAP1 TP53 0 0 779 783 1 2
    KEAP1 ALOX15 0 0 181 181 1 1
    KEAP1 TRIM16 0 0 203 203 1 2
    KEAP1 CD300C 0 0 865 865 1 1
    KEAP1 EIF2AK4 0 0 193 224 1 1
    KEAP1 GCLM 0 0 803 891 1 1
    KEAP1 NQO2 0 0 361 370 1 1
    KEAP1 SFPQ 0 0 486 486 1 1
    KEAP1 PSMD10 270 0 846 884 1 1
    KEAP1 ALDH1L2 0 0 122 204 1 1
    KEAP1 CLU 130 0 56 150 1 2
    KEAP1 BRD4 0 0 240 256 1 1
    KEAP1 ENC1 270 900 233 928 1 1
    KEAP1 HDAC6 0 0 373 426 1 2
    KEAP1 APAF1 0 0 425 449 1 1
    KEAP1 BOD1L1 128 0 0 155 1 1
    KEAP1 JAK2 0 0 204 204 1 1
    KEAP1 BRD7 270 0 45 291 1 1
    KEAP1 NEU2 272 0 0 272 1 1
    KEAP1 ERO1L 0 0 193 210 1 1
    KEAP1 SLBP 0 0 90 209 1 1
    KEAP1 ABCC4 0 0 265 277 1 1
    KEAP1 SPARC 0 0 450 454 1 1
    KEAP1 SMAD3 0 300 235 453 1 1
    KEAP1 BIRC3 0 0 112 178 1 1
    KEAP1 DOK1 0 0 646 646 1 1
    KEAP1 MSRB2 0 0 188 188 1 1
    KEAP1 IL4 0 0 235 235 1 1
    KEAP1 EP300 0 0 310 368 1 1
    KEAP1 CDK5 0 0 142 235 1 2
    KEAP1 CASP7 0 0 182 239 1 1
    KEAP1 KCTD17 0 900 122 911 1 1
    KEAP1 CUL1 0 0 518 669 1 1
    KEAP1 ELAVL1 0 0 181 186 1 1
    KEAP1 ABCC3 0 0 265 277 1 1
    KEAP1 PMF1 0 0 539 539 1 1
    KEAP1 CCL2 0 0 371 371 1 2
    KEAP1 ALB 0 0 503 556 1 1
    KEAP1 CD68 0 0 155 154 1 1
    KEAP1 SNAI2 0 0 134 252 1 1
    KEAP1 CYP4F12 0 0 0 229 1 1
    KEAP1 ALK 0 0 358 358 1 1
    KEAP1 MRPS7 0 0 451 451 1 1
    KEAP1 CYP3A4 0 0 218 233 1 1
    KEAP1 PDE4A 0 0 107 162 1 1
    KEAP1 MAF 0 0 989 989 1 1
    KEAP1 GLMN 0 720 0 720 1 1
    KEAP1 CDH1 367 0 257 509 1 1
    KEAP1 NCF4 0 0 160 159 1 1
    KEAP1 IGF2BP1 0 0 0 209 1 1
    KEAP1 IDH1 0 0 390 397 1 1
    KEAP1 PRKCZ 130 0 171 247 1 1
    KEAP1 EPM2A 0 0 0 208 1 1
    KEAP1 PDGFRA 0 0 203 203 1 1
    KEAP1 CBR3 0 0 207 252 1 1
    KEAP1 CTH 0 0 392 392 1 1
    KEAP1 SIRT6 0 0 369 394 1 1
    KEAP1 TADA2B 0 0 0 197 1 1
    KEAP1 MAP2K4 0 0 156 170 1 1
    KEAP1 WRAP53 0 0 74 216 1 1
    KEAP1 MAPK8 0 0 534 565 1 2
    KEAP1 URI1 270 0 216 416 1 1
    KEAP1 VPS52 0 0 243 271 1 1
    KEAP1 DIABLO 0 0 167 167 1 1
    KEAP1 PSMD11 0 0 142 205 1 1
    KEAP1 SESN2 270 0 936 955 1 2
    KEAP1 BLVRA 0 0 267 267 1 1
    KEAP1 VR1 0 0 194 194 1 1
    KEAP1 GPX4 0 0 505 704 1 1
    KEAP1 TAT 0 0 0 205 1 1
    KEAP1 CBR1 0 0 242 300 1 1
    KEAP1 ACHE 0 0 181 198 1 1
    KEAP1 PPARA 0 0 452 460 1 1
    KEAP1 KLHL41 0 900 134 903 1 1
    KEAP1 HSPB3 0 0 205 205 1 1
    KEAP1 CYP2E1 0 0 416 501 1 1
    KEAP1 HSP90B1 0 0 134 185 1 1
    KEAP1 B3GAT2 0 0 145 330 1 1
    KEAP1 DICER1 0 0 134 170 1 1
    KEAP1 PIK3R1 0 0 209 215 1 1
    KEAP1 CYP1B1 0 0 296 382 1 1
    KEAP1 HSPA4 0 0 421 446 1 1
    KEAP1 POLR2J 0 0 48 206 1 1
    KEAP1 ADD2 0 0 0 151 1 1
    KEAP1 EGF 0 0 304 304 1 1
    KEAP1 HNF1A 0 0 137 155 1 1
    KEAP1 DUSP12 0 0 95 182 1 1
    KEAP1 CYCS 0 0 504 514 1 1
    KEAP1 GGA1 0 0 0 206 1 1
    KEAP1 SESN3 0 0 261 308 1 1
    KEAP1 TRAF6 0 0 483 695 1 2
    KEAP1 PYHIN1 270 0 0 270 1 1
    KEAP1 SREK1 0 0 49 414 1 1
    KEAP1 ZBTB16 0 0 57 188 1 1
    KEAP1 ABCC5 0 0 206 224 1 1
    KEAP1 AIF1 0 0 193 205 1 1
    KEAP1 ERBB4 0 0 202 207 1 1
    KEAP1 GSTA4 0 0 424 539 1 1
    KEAP1 CCNA2 0 0 181 227 1 1
    KEAP1 NOS1 0 0 261 267 1 1
    KEAP1 CYP7A1 0 0 96 169 1 1
    KEAP1 DNTT 0 0 294 307 1 1
    KEAP1 TAF1 129 0 46 152 1 1
    KEAP1 DAPK1 0 0 141 154 1 2
    KEAP1 CNGA1 0 0 0 396 1 1
    KEAP1 ASF1B 0 0 0 166 1 1
    KEAP1 ASF1A 0 0 0 192 1 1
    KEAP1 JUN 0 0 684 703 1 1
    KEAP1 CYP19A1 0 0 134 166 1 1
    KEAP1 MTHFD2 0 0 233 232 1 1
    KEAP1 SOD1 0 0 595 666 1 1
    KEAP1 CDC25C 0 0 112 166 1 1
    KEAP1 ARNT 0 0 290 316 1 2
    KEAP1 AKR1C2 0 0 325 334 1 1
    KEAP1 TXNL4A 0 0 73 156 1 1
    KEAP1 JAG1 0 0 96 152 1 1
    KEAP1 FYN 0 0 417 444 1 1
    KEAP1 ZNF800 0 0 0 161 1 1
    KEAP1 NCOA3 0 0 181 181 1 1
    KEAP1 SLC7A9 0 0 0 213 1 1
    KEAP1 SLC44A2 0 0 721 727 1 1
    KEAP1 CPEB2 192 0 45 204 1 1
    KEAP1 COMMD5 0 600 0 600 1 1
    KEAP1 SLC7A10 0 0 0 245 1 1
    KEAP1 SMAD1 0 300 0 315 1 1
    KEAP1 UCHL1 0 0 148 169 1 1
    KEAP1 SORD 0 0 107 162 1 1
    KEAP1 UGT1A8 0 0 392 433 1 1
    KEAP1 MFN1 0 0 270 306 1 1
    KEAP1 TNNI3 0 0 140 238 1 1
    KEAP1 BAX 0 0 326 325 1 2
    KEAP1 TIMP1 0 0 166 165 1 1
    KEAP1 CDKN1A 0 0 325 325 1 2
    KEAP1 NUDT4 297 0 0 297 1 1
    KEAP1 RAD51AP1 0 0 90 249 1 1
    KEAP1 AR 0 0 218 230 1 1
    KEAP1 RNF8 0 0 81 220 1 1
    KEAP1 PIP5K1B 0 0 72 462 1 1
    KEAP1 SLC25A14 0 0 357 357 1 1
    KEAP1 ICAM1 116 0 325 406 1 1
    KEAP1 SOX2 0 0 322 321 1 1
    KEAP1 PSMA2 0 0 60 225 1 1
    KEAP1 PSEN1 0 0 210 245 1 2
    KEAP1 ATF2 0 0 144 209 1 1
    KEAP1 CRP 0 0 181 192 1 1
    KEAP1 HSP90AA1 270 0 748 815 1 2
    KEAP1 HDAC4 0 0 171 212 1 1
    KEAP1 KLHDC1 0 0 134 205 1 1
    KEAP1 PRRX1 0 0 142 187 1 1
    KEAP1 MTHFD1 0 0 95 151 1 1
    KEAP1 MMP9 0 0 325 336 1 1
    KEAP1 MAPK3 0 0 582 621 1 2
    KEAP1 CUL4A 0 0 219 374 1 1
    KEAP1 CRYZ 0 0 710 717 1 1
    KEAP1 PCK2 0 0 140 243 1 1
    KEAP1 DCAF12 0 0 74 152 1 1
    KEAP1 BNIP3 0 0 286 317 1 2
    KEAP1 SQSTM1 913 0 989 999 1 2
    KEAP1 ATG13 0 0 218 245 1 2
    KEAP1 UBE2E1 0 0 0 176 1 1
    KEAP1 ALDH3A1 0 0 242 260 1 1
    KEAP1 WHSC1L1 0 0 109 155 1 1
    KEAP1 KLHL12 0 900 459 908 1 1
    KEAP1 USP17L2 270 0 540 657 1 1
    KEAP1 BNIP3L 0 0 265 265 1 2
    KEAP1 RBX1 874 900 988 999 1 1
    KEAP1 TSC2 0 0 298 392 1 2
    KEAP1 RB1 0 0 156 174 1 2
    KEAP1 WDR83 466 0 0 477 1 1
    KEAP1 GSTM4 0 0 95 568 1 1
    KEAP1 STK3 270 0 0 296 1 1
    KEAP1 CDKN1B 0 0 155 154 1 2
    KEAP1 HMOX1 0 0 878 904 1 2
    KEAP1 TCHP 0 0 481 481 1 1
    KEAP1 GLRX 0 0 468 487 1 1
    KEAP1 PIAS4 0 0 0 171 1 1
    KEAP1 TOMM20 0 0 232 248 1 1
    KEAP1 CYP2C9 0 0 134 330 1 1
    KEAP1 UBA3 0 0 112 182 1 1
    KEAP1 STX17 0 0 142 204 1 2
    KEAP1 EIF2S1 0 0 310 352 1 2
    KEAP1 LDHB 0 0 72 153 1 1
    KEAP1 COMMD3 0 600 0 611 1 1
    KEAP1 OXR1 297 0 56 337 1 1
    KEAP1 JAK1 0 0 181 181 1 1
    KEAP1 MITF 0 0 134 222 1 1
    KEAP1 KLHL2 682 720 407 915 1 1
    KEAP1 PSMB5 0 0 298 395 1 1
    KEAP1 VHL 0 0 195 200 1 1
    KEAP1 FBXW11 131 0 134 294 1 1
    KEAP1 ZNHIT6 0 0 61 180 1 1
    KEAP1 EIF2AK3 0 0 958 958 1 2
    KEAP1 UGT2B7 0 0 52 151 1 1
    KEAP1 ERICH5 232 0 74 258 1 1
    KEAP1 KLHL7 0 900 241 904 1 1
    KEAP1 ACLY 0 0 241 280 1 1
    KEAP1 UBE2C 0 0 0 153 1 1
    KEAP1 KLHL13 0 900 171 903 1 1
    KEAP1 COMMD10 0 600 0 600 1 1
    KEAP1 MB 0 0 180 179 1 1
    KEAP1 MCU 0 0 122 156 1 1
    KEAP1 KDM6A 0 0 180 194 1 1
    KEAP1 SRC 0 0 334 358 1 1
    KEAP1 SCD 0 0 193 211 1 1
    KEAP1 SMURF2 0 500 66 543 1 1
    KEAP1 TIMM44 0 0 0 201 1 1
    KEAP1 MCM3 874 0 192 918 1 1
    KEAP1 SLK 613 0 66 646 1 1
    KEAP1 ATG4C 0 0 137 195 1 2
    KEAP1 NR1I2 0 0 300 316 1 1
    KEAP1 MAFK 0 0 790 841 1 1
    KEAP1 MAP3K1 0 0 166 165 1 1
    KEAP1 UGT1A6 0 0 395 436 1 1
    KEAP1 ENSG00000274276 0 0 335 375 1 1
    KEAP1 PRDX3 0 0 341 409 1 1
    KEAP1 ERBB2 0 0 392 396 1 2
    KEAP1 PMF1-BGLAP 0 0 539 539 1 1
    KEAP1 UBE2E2 0 0 66 253 1 1
    KEAP1 FBXL17 847 0 51 855 1 1
    KEAP1 CYP2C19 0 0 92 298 1 1
    KEAP1 BBC3 0 0 170 169 1 1
    KEAP1 GSK3A 0 0 51 217 1 1
    KEAP1 SIRT4 0 0 344 351 1 1
    KEAP1 CSMD3 0 0 144 338 1 1
    KEAP1 TSC22D2 270 0 0 270 1 1
    KEAP1 CAAP1 0 0 142 160 1 1
    KEAP1 RNF7 0 0 150 163 1 1
    KEAP1 MAFG 0 0 612 701 1 1
    KEAP1 DHX16 0 0 0 152 1 1
    KEAP1 CXCL10 0 0 156 155 1 1
    KEAP1 FGFR1 0 0 310 309 1 1
    KEAP1 ATF6 0 0 370 413 1 2
    KEAP1 GSTM1 0 0 457 511 1 1
    KEAP1 IKBKB 871 0 985 998 1 1
    KEAP1 KLF4 0 0 150 166 1 1
    KEAP1 CYP2A7 0 0 0 233 1 1
    KEAP1 ASNS 0 0 145 222 1 1
    KEAP1 XIAP 0 0 248 277 1 1
    KEAP1 PPP2R4 0 0 143 177 1 1
    KEAP1 DLG1 0 0 0 323 1 1
    KEAP1 RUNX2 0 0 380 380 1 1
    KEAP1 PSPH 0 0 157 174 1 1
    KEAP1 AKT1 0 0 967 970 1 2
    KEAP1 ETF1 770 0 0 775 1 1
    KEAP1 PPP1R13L 270 0 851 887 1 1
    KEAP1 PPARG 0 0 601 607 1 1
    KEAP1 ERP29 0 0 73 232 1 1
    KEAP1 CD4 0 0 219 219 1 1
    KEAP1 ATF4 0 0 498 504 1 2
    KEAP1 FIS1 0 0 218 237 1 2
    KEAP1 SLC22A7 0 0 82 300 1 1
    KEAP1 NAIP 0 0 0 166 1 1
    KEAP1 CNGA2 0 0 66 362 1 1
    KEAP1 PEBP1 0 0 212 229 1 1
    KEAP1 SLC7A11 0 0 603 678 1 1
    KEAP1 XIRP2 0 0 45 185 1 1
    KEAP1 STIP1 0 0 70 246 1 1
    KEAP1 PPP1R15A 114 0 171 259 1 2
    KEAP1 USP14 0 0 108 524 1 1
    KEAP1 EEF2 270 0 185 431 1 1
    KEAP1 PSMD6 0 0 165 215 1 1
    KEAP1 TNF 0 0 518 544 1 1
    KEAP1 RNF4 0 0 182 249 1 1
    KEAP1 NBR1 270 0 405 597 1 2
    KEAP1 PTMA 760 0 988 997 1 1
    KEAP1 GFER 0 0 157 193 1 1
    KEAP1 PIAS2 0 0 442 517 1 1
    KEAP1 MMP3 0 0 134 173 1 1
    KEAP1 GPRASP2 218 0 0 218 1 1
    KEAP1 CDH5 130 0 95 178 1 1
    KEAP1 PGAM1 0 0 91 216 1 1
    KEAP1 G3BP1 0 0 67 173 1 1
    KEAP1 ATF3 0 0 289 305 1 1
    KEAP1 UVRAG 0 0 194 219 1 2
    KEAP1 ARNTL 0 0 150 169 1 1
    KEAP1 FHIT 0 0 120 187 1 1
    KEAP1 AGT 0 0 62 150 1 1
    KEAP1 CDK13 207 0 0 221 1 1
    KEAP1 TFRC 0 0 155 154 1 1
    KEAP1 GSTP1 0 0 528 570 1 1
    KEAP1 NFKB2 0 0 114 156 1 1
    KEAP1 FAM117B 464 0 171 556 1 1
    KEAP1 ATG4B 0 0 181 246 1 2
    KEAP1 ATP12A 0 0 161 199 1 1
    KEAP1 PIK3C2G 0 0 91 183 1 1
    KEAP1 CYP2A6 0 0 112 290 1 1
    KEAP1 GLRX2 0 0 289 294 1 1
    KEAP1 TXNIP 0 0 334 334 1 1
    KEAP1 ABCG2 0 0 275 293 1 1
    KEAP1 DVL2 0 0 0 172 1 1
    KEAP1 ATR 0 0 122 185 1 1
    KEAP1 CDC42SE2 0 0 134 152 1 1
    KEAP1 ADH5 0 0 150 181 1 1
    KEAP1 ALDH2 0 0 145 209 1 1
    KEAP1 HSF2 0 0 0 157 1 1
    KEAP1 CD274 0 0 251 250 1 1
    KEAP1 FAM129B 683 0 597 870 1 1
    KEAP1 PC 0 0 172 196 1 1
    KEAP1 COMMD7 0 600 0 611 1 1
    KEAP1 RPS6KB1 0 0 314 336 1 2
    KEAP1 SLC7A8 0 0 45 249 1 1
    KEAP1 REM1 0 0 0 197 1 1
    KEAP1 CDK1 0 0 187 187 1 1
    KEAP1 LEPREL2 130 0 134 214 1 1
    KEAP1 SERPINE1 0 0 181 181 1 1
    KEAP1 AHR 0 0 711 711 1 1
    KEAP1 SESN1 270 0 325 519 1 2
    KEAP1 IRS1 0 0 244 260 1 1
    KEAP1 HSPA9 0 0 112 152 1 1
    KEAP1 LOX 0 0 222 222 1 1
    KEAP1 DDI2 0 0 146 172 1 1
    KEAP1 ZFYVE9 0 0 0 191 1 1
    KEAP1 MECOM 0 0 76 156 1 1
    KEAP1 OSBPL10 131 0 0 193 1 1
    KEAP1 HGF 0 0 150 168 1 1
    KEAP1 GUCY2F 0 0 0 338 1 1
    KEAP1 KIF14 270 0 0 270 1 1
    KEAP1 MCM7 0 0 96 261 1 1
    KEAP1 POU5F1 0 0 148 163 1 1
    KEAP1 CAT 111 0 739 804 1 1
    KEAP1 BARD1 0 0 135 596 1 1
    KEAP1 PSMA3 0 0 112 191 1 1
    KEAP1 GSTT2B 0 0 140 159 1 1
    KEAP1 SEP15 0 0 81 176 1 1
    KEAP1 CTLA4 0 0 164 163 1 1
    KEAP1 BTBD19 0 0 0 153 1 1
    KEAP1 KCTD10 0 720 0 720 1 1
    KEAP1 DDIT4 103 0 161 215 1 1
    KEAP1 ZNF831 0 0 119 486 1 1
    KEAP1 BCL2 270 0 107 328 1 2
    KEAP1 UBE2M 0 0 211 229 1 1
    KEAP1 KIT 0 0 193 193 1 1
    KEAP1 NFE2L1 834 0 585 994 1 1
    KEAP1 AMBRA1 0 0 184 200 1 2
    KEAP1 LDHA 0 0 216 245 1 1
    KEAP1 DOCK4 0 0 0 200 1 1
    KEAP1 KAT5 0 0 90 310 1 2
    KEAP1 PSMC3 0 0 112 193 1 1
    KEAP1 C8orf22 0 0 105 177 1 1
    KEAP1 KLHL40 0 720 103 726 1 1
    KEAP1 FTL 0 0 266 278 1 1
    KEAP1 POU2F3 0 0 156 376 1 1
    KEAP1 ACSL4 0 0 181 198 1 1
    KEAP1 TERF1 295 0 0 295 1 1
    KEAP1 RNF14 0 0 0 183 1 1
    KEAP1 GAPDHS 0 0 0 232 1 1
    KEAP1 SLC22A2 0 0 71 292 1 1
    KEAP1 NR1H4 0 0 251 262 1 1
    KEAP1 DLG4 0 0 95 316 1 1
    KEAP1 NPM1 270 0 108 361 1 1
    KEAP1 SNAI1 0 0 209 209 1 1
    KEAP1 IL10 0 0 341 350 1 1
    KEAP1 UGT1A5 0 0 74 177 1 1
    KEAP1 UBE2S 0 0 141 226 1 1
    KEAP1 BRMS1 0 0 0 160 1 1
    KEAP1 SLC25A32 0 0 62 238 1 1
    KEAP1 GUCY2D 0 0 0 417 1 1
    KEAP1 IGF2 0 0 124 275 1 1
    KEAP1 UBE2O 0 0 60 179 1 1
    KEAP1 HLA-A 0 0 212 212 1 1
    KEAP1 SETD2 0 0 334 358 1 1
    KEAP1 ULK1 270 0 362 536 1 2
    KEAP1 TXLNG 0 0 67 158 1 1
    KEAP1 PRKCA 0 900 211 917 1 1
    KEAP1 KLHL42 0 900 96 909 1 1
    KEAP1 NONO 0 0 416 416 1 1
    KEAP1 MMP13 0 0 141 159 1 1
    KEAP1 GEM 0 0 0 390 1 1
    KEAP1 PAQR3 270 0 404 546 1 2
    KEAP1 MPST 0 0 359 381 1 1
    KEAP1 TBP 0 0 203 203 1 1
    KEAP1 FN1 0 0 294 294 1 1
    KEAP1 TERT 0 0 325 341 1 1
    KEAP1 TET2 270 0 131 338 1 1
    KEAP1 MCM2 270 0 66 330 1 1
    KEAP1 NCF2 0 0 261 261 1 1
    KEAP1 NKX2-1 0 0 205 205 1 1
    KEAP1 LOR 0 0 108 163 1 1
    KEAP1 HMOX2 0 0 464 740 1 1
    KEAP1 ENSG00000228049 0 0 0 178 1 1
    KEAP1 MAP1LC3B 309 0 439 638 1 2
    KEAP1 HHAT 0 0 171 214 1 1
    KEAP1 RIN3 0 0 45 195 1 1
    KEAP1 UBC 486 600 57 797 1 1
    KEAP1 SASS6 131 0 0 150 1 1
    KEAP1 LAMA1 270 0 0 285 1 1
    KEAP1 CYP2C8 0 0 64 276 1 1
    KEAP1 MYO7A 192 0 712 784 1 1
    KEAP1 TRIP6 0 0 0 180 1 1
    KEAP1 CACUL1 0 0 82 218 1 1
    KEAP1 DYNC1H1 0 0 82 178 1 1
    KEAP1 CALCOCO2 0 0 325 325 1 2
    KEAP1 GAN 0 900 341 910 1 1
    KEAP1 MIB1 0 0 66 184 1 1
    KEAP1 EPHX1 0 0 339 417 1 1
    KEAP1 IRF1 157 0 113 220 1 1
    KEAP1 ATP4A 0 0 161 203 1 1
    KEAP1 SLC22A5 0 0 46 412 1 1
    KEAP1 MT1G 0 0 210 210 1 1
    KEAP1 SLC6A3 0 0 134 152 1 1
    KEAP1 YAP1 0 0 289 337 1 1
    KEAP1 SLX4 270 0 0 270 1 1
    KEAP1 LMNB1 0 0 372 468 1 1
    KEAP1 ESR1 0 0 325 335 1 1
    KEAP1 IFNB1 0 0 202 202 1 1
    KEAP1 UBE2D2 0 0 114 220 1 1
    KEAP1 NSD1 0 0 194 236 1 1
    KEAP1 WLS 0 0 0 223 1 1
    KEAP1 SENP3 0 0 70 211 1 1
    KEAP1 SMAD7 0 500 166 565 1 1
    KEAP1 TRPA1 0 0 284 295 1 1
    KEAP1 OPTN 131 0 263 332 1 2
    KEAP1 MLH1 0 0 136 183 1 1
    KEAP1 MAPK11 0 0 74 332 1 1
    KEAP1 DUSP1 0 0 142 159 1 1
    KEAP1 PIAS1 0 0 0 171 1 1
    KEAP1 IL2 0 0 181 181 1 1
    KEAP1 GIT2 0 0 0 157 1 1
    KEAP1 ABCC1 0 0 325 336 1 1
    KEAP1 BECN1 0 0 467 522 1 2
    KEAP1 MAPT 0 0 823 823 1 2
    KEAP1 ABCB1 0 0 233 263 1 1
    KEAP1 RBBP8 0 0 154 153 1 1
    KEAP1 LPIN1 0 0 133 172 1 2
    KEAP1 CAPN9 0 0 0 157 1 1
    KEAP1 PSMD2 270 0 62 302 1 1
    KEAP1 MCM6 0 0 52 207 1 1
    KEAP1 PON1 0 0 142 157 1 1
    KEAP1 PPAT 0 0 181 186 1 1
    KEAP1 RXRA 0 0 169 258 1 1
    KEAP1 TCEB1 0 0 240 239 1 1
    KEAP1 FASLG 0 0 194 194 1 1
    KEAP1 GNMT 0 0 65 181 1 1
    KEAP1 CYP2A13 0 0 48 238 1 1
    KEAP1 ZNF706 0 0 0 154 1 1
    KEAP1 TKT 0 0 334 347 1 1
    KEAP1 PKN2 0 0 54 150 1 1
    KEAP1 KLHDC8A 0 0 0 184 1 1
    KEAP1 ITGB2 169 0 48 183 1 1
    KEAP1 CNGA3 0 0 0 394 1 1
    KEAP1 KRAS 0 0 561 584 1 1
    KEAP1 MLST8 129 0 134 233 1 2
    KEAP1 GSK3B 0 0 341 502 1 2
    KEAP1 CDC34 270 0 91 406 1 1
    KEAP1 GPX8 0 0 145 609 1 1
    KEAP1 TUBG1 117 0 0 179 1 1
    KEAP1 RPS27A 0 600 72 618 1 1
    KEAP1 CDKN2A 0 0 467 478 1 2
    KEAP1 RIPK1 0 0 212 212 1 1
    KEAP1 MORF4L1 0 0 287 680 1 1
    KEAP1 ACO1 0 0 134 152 1 1
    KEAP1 ABCB4 0 0 124 176 1 1
    KEAP1 TXNRD2 0 0 267 390 1 1
    KEAP1 CEBPB 0 0 213 230 1 1
    KEAP1 ATG16L1 0 0 261 274 1 2
    KEAP1 TXNRD1 0 0 670 719 1 1
    KEAP1 ECSIT 0 0 95 160 1 1
    KEAP1 CASP3 0 0 561 572 1 2
    KEAP1 ERBB3 0 0 172 178 1 1
    KEAP1 LZTS1 0 0 0 163 1 1
    KEAP1 PTGS2 0 0 540 543 1 1
    KEAP1 KLHL11 0 0 343 222 1 1
    KEAP1 SMURF1 0 0 134 157 1 1
    KEAP1 MYH7 211 0 0 263 1 1
    KEAP1 PSMB6 0 0 155 173 1 1
    KEAP1 BRCA2 486 0 336 644 1 1
    KEAP1 NLRP3 0 0 456 456 1 2
    KEAP1 REL 0 0 233 241 1 1
    KEAP1 ATG101 0 0 195 210 1 2
    KEAP1 EGLN1 0 0 211 277 1 1
    KEAP1 SLC7A6 0 0 0 245 1 1
    KEAP1 PTS 0 0 193 193 1 1
    KEAP1 ENSG00000268643 0 0 0 205 1 1
    KEAP1 CYBB 0 0 470 480 1 1
    KEAP1 DLG3 0 0 0 323 1 1
    KEAP1 IL13 0 0 154 153 1 1
    KEAP1 TNFRSF10B 0 0 180 179 1 1
    KEAP1 REN 0 0 233 256 1 1
    KEAP1 SLC1A1 0 0 141 159 1 1
    KEAP1 ACE 0 0 174 174 1 1
    KEAP1 CYP4B1 0 0 44 440 1 1
    KEAP1 XPO1 0 0 426 551 1 1
    KEAP1 PSAT1 0 0 181 192 1 1
    KEAP1 SHMT2 0 0 210 240 1 1
    KEAP1 SLX4IP 0 0 54 155 1 1
    KEAP1 AKR1C3 0 0 447 454 1 1
    KEAP1 MAP1LC3A 644 0 211 792 1 2
    KEAP1 ASTN1 417 0 217 542 1 1
    KEAP1 CDK2 0 0 211 211 1 1
    KEAP1 ASPA 269 0 0 270 1 1
    KEAP1 DOCK1 0 0 0 163 1 1
    KEAP1 GABPA 486 0 424 699 1 1
    KEAP1 PIR 0 0 59 204 1 1
    KEAP1 CLN3 0 0 55 157 1 2
    KEAP1 PSMC2 0 0 123 157 1 1
    KEAP1 SP1 0 0 260 274 1 1
    KEAP1 DLG2 0 0 0 323 1 1
    KEAP1 NAE1 0 0 134 166 1 1
    KEAP1 FAT1 0 0 310 309 1 1
    KEAP1 IL1B 0 0 556 556 1 1
    KEAP1 PRKCB 0 900 120 908 1 2
    KEAP1 EDN1 0 0 194 194 1 1
    KEAP1 HIF1A 0 0 519 572 1 2
    KEAP1 GCK 0 0 89 153 1 1
    KEAP1 SIRT5 0 0 341 355 1 1
    KEAP1 TNFRSF1A 0 0 181 181 1 1
    KEAP1 SHMT1 0 0 155 166 1 1
    KEAP1 CYP2F1 0 0 0 243 1 1
    KEAP1 SLC25A1 0 0 108 160 1 1
    KEAP1 UBE2A 270 0 46 365 1 1
    KEAP1 RNASE1 0 0 53 294 1 1
    KEAP1 TRIM37 270 0 44 272 1 1
    KEAP1 IL6 0 0 520 539 1 1
    KEAP1 UCP2 0 0 270 282 1 1
    KEAP1 PALB2 870 0 986 998 1 1
    KEAP1 MPO 0 0 358 367 1 1
    KEAP1 POTEF 0 0 203 256 1 1
    KEAP1 KPNA1 0 0 138 223 1 1
    KEAP1 CHD6 270 0 335 530 1 1
    KEAP1 CISD1 0 0 135 153 1 1
    KEAP1 NOTCH1 0 0 452 513 1 1
    KEAP1 ABCB11 0 0 157 260 1 1
    KEAP1 PIDD1 314 0 53 346 1 1
    KEAP1 SIAH1 0 0 134 166 1 1
    KEAP1 PLK1 0 0 155 190 1 1
    KEAP1 PRDX6 0 0 288 302 1 1
    KEAP1 RBM45 413 0 687 817 1 1
    KEAP1 EPO 0 0 228 233 1 1
    KEAP1 CUL7 0 0 181 181 1 1
    KEAP1 CYP4F3 0 0 0 233 1 1
    KEAP1 PRDX5 0 0 228 227 1 1
    KEAP1 U2AF1L4 0 0 234 250 1 1
    KEAP1 FOXM1 0 0 120 175 1 1
    KEAP1 WHSC1 0 0 74 155 1 1
    KEAP1 RPS3 0 0 95 173 1 1
    KEAP1 ANXA5 0 0 376 440 1 1
    KEAP1 CS 0 0 180 617 1 1
    KEAP1 CCNB1 129 0 181 288 1 1
    KEAP1 FGF21 0 0 249 248 1 1
    KEAP1 POLE 0 0 181 343 1 1
    KEAP1 CCL5 0 0 150 169 1 1
    KEAP1 DCUN1D5 0 600 118 640 1 1
    KEAP1 IFNG 0 0 171 222 1 2
    KEAP1 BIRC2 0 0 167 199 1 1
    KEAP1 AMER1 675 0 795 930 1 1
    KEAP1 PSMA1 0 0 167 207 1 1
    KEAP1 ARF1 0 0 0 171 1 1
    KEAP1 SPHKAP 0 0 46 306 1 1
    KEAP1 POMP 0 0 210 210 1 1
    KEAP1 LONP1 0 0 150 266 1 1
    KEAP1 SLC22A4 0 0 43 365 1 1
    KEAP1 HAVCR1 0 0 171 171 1 1
    KEAP1 NF1 0 0 370 394 1 1
    KEAP1 BCCIP 0 0 45 183 1 1
    KEAP1 NOS2 0 0 323 328 1 1
    KEAP1 ATRX 0 0 123 212 1 1
    KEAP1 UBE2V2 0 0 96 340 1 1
    KEAP1 GABARAPL2 116 0 325 580 1 2
    KEAP1 PGAM4 0 0 76 203 1 1
    KEAP1 ATG14 0 0 260 273 1 2
    KEAP1 UBP1 0 0 66 364 1 1
    KEAP1 GSTO1 0 0 261 337 1 1
    KEAP1 CYP1A2 0 0 260 282 1 1
    KEAP1 SMAD2 0 300 211 436 1 1
    KEAP1 TLR4 0 0 391 399 1 1
    KEAP1 KLHL24 0 720 0 725 1 1
    KEAP1 BCL2L1 0 0 680 689 1 2
    KEAP1 TUBB4A 0 0 137 150 1 1
    KEAP1 COPG1 131 0 0 171 1 1
    KEAP1 DNMT3A 0 0 194 206 1 1
    KEAP1 TFB1M 0 0 90 160 1 1
    KEAP1 DPP3 872 0 891 986 1 1
    KEAP1 SLC9A1 0 0 0 241 1 1
    KEAP1 PIK3R4 0 0 203 222 1 2
    KEAP1 ME1 0 0 459 483 1 1
    KEAP1 ART4 0 0 0 424 1 1
    KEAP1 USP10 0 0 201 242 1 2
    KEAP1 ACACA 0 0 184 183 1 1
    KEAP1 NR1I3 0 0 294 305 1 1
    KEAP1 PIK3CA 0 0 460 488 1 2
    KEAP1 MSRA 0 0 187 187 1 1
    KEAP1 GLS 0 0 213 224 1 1
    KEAP1 RNF168 0 0 136 542 1 1
    KEAP1 H1F0 0 0 157 166 1 1
    KEAP1 UBE2D1 0 0 108 233 1 1
    KEAP1 CAPN3 0 0 0 268 1 1
    KEAP1 MTF1 0 0 150 188 1 1
    KEAP1 IGF1R 0 0 204 233 1 1
    KEAP1 SDHC 0 0 279 279 1 1
    KEAP1 COL11A1 0 0 74 235 1 1
    KEAP1 IL18 0 0 240 241 1 1
    KEAP1 PPIG 0 0 310 330 1 1
    KEAP1 APEX1 0 0 242 258 1 1
    KEAP1 PDK1 0 0 155 174 1 1
    KEAP1 MYC 0 0 509 519 1 2
    KEAP1 MFF 0 0 181 225 1 1
    KEAP1 MAP2K1 0 0 294 294 1 1
    KEAP1 PPIF 0 0 232 263 1 1
    KEAP1 CAND1 0 0 302 332 1 1
    KEAP1 TADA2A 0 0 0 201 1 1
    KEAP1 AKT2 0 0 150 242 1 1
    KEAP1 EML4 0 0 218 236 1 1
    KEAP1 CDK20 270 0 166 416 1 1
    KEAP1 UBE2K 0 0 142 262 1 1
    KEAP1 BACH2 0 0 282 401 1 1
    KEAP1 NFE2L2 992 900 990 999 1 1
    KEAP1 PGAM5 874 0 989 998 1 1
    KEAP1 NHLRC2 270 0 0 270 1 1
    KEAP1 FBXW8 270 0 74 320 1 1
    KEAP1 MAP2K5 0 0 205 205 1 1
    KEAP1 TAX1BP1 0 0 193 193 1 2
    KEAP1 FXN 0 0 278 397 1 1
    KEAP1 PARK7 0 0 932 942 1 1
    KEAP1 SRSF11 0 0 0 223 1 1
    KEAP1 UGT3A1 0 0 0 175 1 1
    KEAP1 UBA1 0 0 136 212 1 1
    KEAP1 HDAC3 0 0 210 268 1 1
    KEAP1 SMAD4 0 0 279 279 1 1
    KEAP1 ARCN1 131 0 0 158 1 1
    KEAP1 DDIT3 270 0 391 536 1 2
    KEAP1 KLHDC2 0 0 140 293 1 1
    KEAP1 SIAH2 0 0 172 246 1 1
    KEAP1 HK2 0 0 233 249 1 1
    KEAP1 NTSR1 0 0 448 448 1 1
    KEAP1 KLHL8 0 900 236 908 1 1
    KEAP1 PTPRD 0 0 142 273 1 1
    KEAP1 LMNA 0 0 270 335 1 1
    KEAP1 CDK4 0 0 294 294 1 1
    KEAP1 MYD88 0 0 212 245 1 1
    KEAP1 FADD 0 0 134 151 1 2
    KEAP1 DCUN1D1 0 600 142 645 1 1
    KEAP1 CFTR 0 0 156 170 1 1
    KEAP1 TRIM24 0 0 122 171 1 1
    KEAP1 TALDO1 0 0 323 334 1 1
    KEAP1 PRKCI 130 0 57 151 1 1
    KEAP1 STAT3 0 0 391 404 1 2
    KEAP1 EZH2 0 0 193 222 1 1
    KEAP1 UBE2T 0 0 0 173 1 1
    KEAP1 VDAC2 0 0 167 173 1 1
    KEAP1 EIF4G3 0 0 0 166 1 1
    KEAP1 NF2 0 0 444 448 1 1
    KEAP1 SLC22A3 0 0 0 269 1 1
    KEAP1 XRCC6 0 0 126 172 1 1
    KEAP1 ERN1 0 0 342 342 1 2
    KEAP1 SH3BP5 0 0 162 182 1 1
    KEAP1 RALBP1 0 0 134 171 1 1
    KEAP1 MAFF 0 0 556 569 1 1
    KEAP1 GSTK1 0 0 240 257 1 1
    KEAP1 CYBA 0 0 293 307 1 1
    KEAP1 PDCD6 0 720 0 724 1 1
    KEAP1 COL2A1 232 0 0 249 1 1
    KEAP1 ARL17A 0 0 0 171 1 1
    KEAP1 PIP5K1C 0 0 0 220 1 1
    KEAP1 BLVRB 0 0 125 156 1 1
    KEAP1 ZMIZ1 0 0 0 178 1 1
    KEAP1 ABCB6 0 0 142 244 1 1
    KEAP1 NOTCH3 0 0 113 174 1 1
    KEAP1 ENSG00000272822 0 0 0 324 1 1
    KEAP1 ADD3 0 0 0 175 1 1
    KEAP1 GPX5 0 0 175 607 1 1
    KEAP1 SPOPL 0 900 0 913 1 1
    KEAP1 COMMD1 0 600 0 600 1 1
    KEAP1 MOXD1 0 0 134 161 1 1
    KEAP1 PLEKHO1 0 0 210 210 1 1
    KEAP1 SDHA 0 0 202 240 1 1
    KEAP1 CASP8 0 0 390 393 1 2
    KEAP1 GADD45GIP1 0 0 228 256 1 1
    KEAP1 MCM4 0 0 49 188 1 1
    KEAP1 ZMIZ2 0 0 0 171 1 1
    KEAP1 ABCA1 0 0 134 167 1 1
    KEAP1 CUL5 0 0 230 344 1 1
    KEAP1 FECH 0 0 242 241 1 1
    KEAP1 SPEF2 0 0 0 248 1 1
    KEAP1 IL1A 0 0 183 183 1 1
    KEAP1 H2AFX 0 0 243 273 1 1
    KEAP1 LGALS4 0 0 217 217 1 1
    KEAP1 CLDN12 0 0 211 235 1 1
    KEAP1 DPP4 0 0 150 215 1 1
    KEAP1 SLC3A2 0 0 218 247 1 1
    KEAP1 MORF4L2 0 0 134 174 1 1
    KEAP1 PLG 0 0 144 159 1 1
    KEAP1 MLXIPL 0 0 123 155 1 1
    KEAP1 TRIM21 0 0 770 770 1 1
    KEAP1 OSGIN1 0 0 265 311 1 1
    KEAP1 CDK6 273 0 194 392 1 1
    KEAP1 KMT2B 0 0 390 405 1 1
    KEAP1 HYOU1 0 0 94 232 1 1
    KEAP1 UBE2D4 0 0 0 156 1 1
    KEAP1 AKTIP 0 0 0 225 1 1
    KEAP1 TRIM16L 0 0 210 210 1 1
    KEAP1 IPO11 270 0 81 325 1 1
    KEAP1 GCLC 0 0 852 919 1 1
    KEAP1 SKP2 0 0 171 222 1 1
    KEAP1 ARG1 0 0 165 183 1 1
    KEAP1 ADIPOQ 0 0 210 210 1 1
    KEAP1 KCTD2 0 540 62 550 1 1
    KEAP1 NXN 0 0 140 166 1 1
    KEAP1 NR3C1 0 0 181 204 1 1
    KEAP1 ENY2 0 0 0 234 1 1
    KEAP1 CYP2B6 0 0 134 309 1 1
    KEAP1 VANGL2 0 0 425 430 1 1
    KEAP1 CTGF 0 0 194 194 1 1
    KEAP1 HIST2H3PS2 0 0 365 379 1 1
    KEAP1 IFIH1 232 0 53 251 1 1
    KEAP1 TNS1 0 0 204 218 1 1
    KEAP1 KLF5 0 0 436 447 1 1
    KEAP1 MTHFD1L 0 0 113 168 1 1
    KEAP1 CLDN3 0 0 147 233 1 1
    KEAP1 GNAS 0 0 112 186 1 1
    KEAP1 BPTF 270 0 197 394 1 1
    KEAP1 NES 270 0 82 319 1 1
    KEAP1 RPTOR 0 0 293 335 1 2
    KEAP1 PSMD4 270 0 202 426 1 1
    KEAP1 CYP4F11 0 0 101 307 1 1
    KEAP1 FASN 68 0 218 259 1 1
    KEAP1 SETD7 0 0 167 197 1 1
    KEAP1 AKR1B1 0 0 350 367 1 1
    KEAP1 TMEM59 0 0 45 150 1 1
    KEAP1 IL17A 0 0 177 177 1 1
    KEAP1 KBTBD8 0 900 0 900 1 1
    KEAP1 MAPK9 0 0 181 220 1 2
    KEAP1 OGG1 0 0 320 330 1 1
    KEAP1 CWC27 0 0 0 169 1 1
    KEAP1 RPS6KA3 0 0 261 261 1 1
    KEAP1 CHEK2 0 0 232 272 1 1
    KEAP1 CASP9 0 0 395 396 1 1
    KEAP1 MAP2K3 0 0 155 162 1 1
    KEAP1 ULK2 0 0 150 188 1 2
    KEAP1 ARL17B 0 0 0 171 1 1
    KEAP1 HSPA1A 0 0 233 288 1 1
    KEAP1 HLA-DRB1 0 0 698 698 1 1
    KEAP1 GPKOW 0 0 74 231 1 1
    KEAP1 CAV1 0 0 462 462 1 1
    KEAP1 CASP1 270 0 293 465 1 2
    KEAP1 NEIL2 270 0 989 992 1 1
    KEAP1 SNCA 0 0 374 374 1 2
    KEAP1 SLC25A27 0 0 389 388 1 1
    KEAP1 CHEK1 0 0 218 218 1 1
    KEAP1 MAFB 0 0 95 296 1 1
    KEAP1 DVL3 0 0 0 172 1 1
    KEAP1 RHOT1 0 0 112 163 1 1
    KEAP1 MGST3 0 0 120 242 1 1
    KEAP1 NRF1 0 0 336 597 1 1
    KEAP1 KPNA6 270 0 469 620 1 1
    KEAP1 BCL2L11 0 0 277 277 1 1
    KEAP1 CSNK1A1 0 0 73 207 1 1
    KEAP1 PRDX1 0 0 563 608 1 1
    KEAP1 ERN2 0 0 107 199 1 1
    KEAP1 MIB2 0 0 0 157 1 1
    KEAP1 USP4 0 0 0 160 1 1
    KEAP1 HDLBP 0 0 60 200 1 1
    KEAP1 LAMP2 0 0 124 164 1 2
    KEAP1 NEIL1 0 0 66 475 1 1
    KEAP1 SPOP 0 900 392 926 1 1
    KEAP1 PIP5K1A 0 0 0 230 1 1
    KEAP1 CAPN2 0 0 46 205 1 2
    KEAP1 VCP 270 0 212 456 1 2
    KEAP1 CREB3 0 0 325 339 1 1
    KEAP1 MMP2 0 0 232 231 1 1
    KEAP1 IGF2BP3 0 0 0 209 1 1
    KEAP1 SAT1 0 0 573 578 1 1
    KEAP1 TFAM 0 0 358 389 1 1
    KEAP1 CALR 0 0 160 159 1 1
    KEAP1 FUNDC1 0 0 204 214 1 2
    KEAP1 CD8A 0 0 233 232 1 1
    KEAP1 SENP7 0 0 66 164 1 1
    KEAP1 PSMB8 0 0 102 189 1 1
    KEAP1 PGAM2 0 0 0 173 1 1
    KEAP1 TARDBP 0 0 141 151 1 1
    KEAP1 PLA2G1B 0 0 170 169 1 1
    KEAP1 GABPB1 0 0 324 360 1 1
    KEAP1 UBE2N 0 0 74 185 1 1
    KEAP1 NKRF 0 0 828 834 1 1
    KEAP1 GSR 0 0 709 719 1 1
    KEAP1 HSPA8 107 0 183 307 1 2
    KEAP1 UBE2L3 0 0 92 190 1 1
    KEAP1 EIF4G1 0 0 0 155 1 2
    KEAP1 PARP1 0 0 283 293 1 2
    KEAP1 RHOA 0 0 195 208 1 1
    KEAP1 SIRT7 0 0 338 345 1 1
    KEAP1 ZEB1 0 0 202 202 1 1
    KEAP1 GABARAPL1 55 0 361 611 1 2
    KEAP1 STK4 270 0 0 286 1 1
    KEAP1 MLKL 0 0 193 196 1 1
    KEAP1 CYP2R1 0 0 47 174 1 1
    KEAP1 CYP2U1 0 0 95 421 1 1
    KEAP1 COMMD2 0 600 0 602 1 1
    KEAP1 HBE1 0 0 151 150 1 1
    KEAP1 ESR2 0 0 187 200 1 1
    KEAP1 WRN 0 0 58 170 1 1
    KEAP1 CEBPA 0 0 208 216 1 1
    KEAP1 HTRA2 0 0 113 168 1 1
    KEAP1 COX4I1 0 0 261 278 1 1
    KEAP1 SUV39H1 0 0 95 192 1 1
    KEAP1 UGT1A3 0 0 77 179 1 1
    KEAP1 FOSL1 0 0 193 193 1 1
    KEAP1 TFEB 0 0 294 309 1 2
    KEAP1 ZNF804A 0 0 0 366 1 1
    KEAP1 HPGDS 0 0 750 750 1 1
    KEAP1 OR5M11 0 0 96 328 1 1
    KEAP1 FBXW7 0 0 369 384 1 1
    KEAP1 B2M 0 0 171 171 1 1
    KEAP1 ROS1 0 0 324 323 1 1
    KEAP1 KMT2C 0 0 234 253 1 1
    KEAP1 SIRT3 0 0 450 462 1 2
    KEAP1 MCM5 0 0 59 214 1 1
    KEAP1 GLO1 0 0 183 240 1 1
    KEAP1 LRP12 0 0 83 224 1 1
    KEAP1 GLI3 0 0 144 191 1 1
    KEAP1 NAF1 128 0 0 158 1 1
    KEAP1 F2RL2 0 0 46 251 1 1
    KEAP1 INS 0 0 465 465 1 1
    KEAP1 ACTB 0 0 678 700 1 1
    KEAP1 CTTN 270 0 692 781 1 1
    KEAP1 STUB1 0 0 213 260 1 2
    KEAP1 DNMT1 0 0 298 318 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0061629 Molecular Function RNA polymerase II-specific DNA-binding transcription factor binding enables IPI
    GO:0097718 Molecular Function disordered domain specific binding enables IEA
    GO:0042802 Molecular Function identical protein binding enables IEA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0140416 Molecular Function transcription regulator inhibitor activity enables IDA
    GO:1990756 Molecular Function ubiquitin-like ligase-substrate adaptor activity enables IBA
    GO:1990756 Molecular Function ubiquitin-like ligase-substrate adaptor activity enables IDA
    GO:0071353 Biological Process cellular response to interleukin-4 involved_in IEA
    GO:0034599 Biological Process cellular response to oxidative stress involved_in IDA
    GO:0001701 Biological Process in utero embryonic development involved_in IEA
    GO:1902883 Biological Process negative regulation of response to oxidative stress involved_in IDA
    GO:0000122 Biological Process negative regulation of transcription by RNA polymerase II involved_in IDA
    GO:0032436 Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved_in TAS
    GO:0043161 Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process involved_in IBA
    GO:0043161 Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process involved_in IDA
    GO:0016567 Biological Process protein ubiquitination involved_in IDA
    GO:0016567 Biological Process protein ubiquitination involved_in IEA
    GO:0010506 Biological Process regulation of autophagy involved_in IDA
    GO:0045604 Biological Process regulation of epidermal cell differentiation involved_in IEA
    GO:0006511 Biological Process ubiquitin-dependent protein catabolic process involved_in IDA
    GO:0031463 Cellular Component Cul3-RING ubiquitin ligase complex part_of IBA
    GO:0031463 Cellular Component Cul3-RING ubiquitin ligase complex part_of IDA
    GO:0005884 Cellular Component actin filament located_in IEA
    GO:0034451 Cellular Component centriolar satellite located_in IDA
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0005783 Cellular Component endoplasmic reticulum located_in IEA
    GO:0016234 Cellular Component inclusion body located_in IDA
    GO:0030496 Cellular Component midbody located_in IDA
    GO:0005654 Cellular Component nucleoplasm located_in IDA
    Pathways
    Name DB ID
    Adaptive Immune System Reactome R-HSA-1280218
    Disease Reactome R-HSA-1643685
    Immune System Reactome R-HSA-168256
    Cellular responses to stress Reactome R-HSA-2262752
    Metabolism of proteins Reactome R-HSA-392499
    Infectious disease Reactome R-HSA-5663205
    Deubiquitination Reactome R-HSA-5688426
    Ub-specific processing proteases Reactome R-HSA-5689880
    Post-translational protein modification Reactome R-HSA-597592
    Neddylation Reactome R-HSA-8951664
    Cellular responses to stimuli Reactome R-HSA-8953897
    Potential therapeutics for SARS Reactome R-HSA-9679191
    SARS-CoV Infections Reactome R-HSA-9679506
    Cellular response to chemical stress Reactome R-HSA-9711123
    KEAP1-NFE2L2 pathway Reactome R-HSA-9755511
    Viral Infection Pathways Reactome R-HSA-9824446
    Antigen processing: Ubiquitination & Proteasome degradation Reactome R-HSA-983168
    Class I MHC mediated antigen processing & presentation Reactome R-HSA-983169
    Transcriptional activation by NRF2 in response to phytochemicals (WP3) WikiPathways WP3_r120028
    NRF2-ARE regulation (WP4357) WikiPathways WP4357_r98705
    Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling (WP3612) WikiPathways WP3612_r106540
    mRNA, protein, and metabolite inducation pathway by cyclosporin A (WP3953) WikiPathways WP3953_r106206
    Hereditary leiomyomatosis and renal cell carcinoma pathway (WP4206) WikiPathways WP4206_r123458
    Nuclear receptors meta-pathway (WP2882) WikiPathways WP2882_r120815
    Quercetin and Nf-kB / AP-1 induced apoptosis (WP2435) WikiPathways WP2435_r120750
    NRF2 pathway (WP2884) WikiPathways WP2884_r106658
    Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway (WP5113) WikiPathways WP5113_r124660
    Head and neck squamous cell carcinoma (WP4674) WikiPathways WP4674_r123494
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_203500 2 mRNA transcript variant 1 NC_000019 Reference
    NM_012289 4 mRNA transcript variant 2 NC_000019 Reference