ULK2

unc-51 like autophagy activating kinase 2
General Information
Name unc-51 like autophagy activating kinase 2
Alias
  • serine/threonine-protein kinase ULK2
Synonyms KIAA0623 Unc51.2 ATG1B
Gene_family Autophagy related
organism Homo sapiens
entrez_id 9706
location 17p11.2
transcript_count 5
exon_count 28
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
      Stringdb Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG [...]
      nextProt Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    ULK2 BioGRID ULK3 GeneID BioGRID Negative Genetic
    ULK2 BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
    ULK2 BioGRID PRKN GeneID BioGRID Affinity Capture-MS
    ULK2 BioGRID ATG101 GeneID BioGRID Affinity Capture-MS
    ULK2 BioGRID RB1CC1 GeneID BioGRID Affinity Capture-MS
    ULK2 BioGRID KIF14 GeneID BioGRID Affinity Capture-MS
    ULK2 BioGRID SREBF2 GeneID BioGRID Negative Genetic
    ULK2 BioGRID ATG13 GeneID BioGRID Affinity Capture-Western
    ULK2 BioGRID SEC16A GeneID BioGRID Affinity Capture-Western
    ULK2 BioGRID RPTOR GeneID BioGRID Affinity Capture-Western
    ULK2 BioGRID TNPO1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    ULK2 BioGRID DUXAP9 GeneID BioGRID Protein-RNA
    ULK2 BioGRID PSMD14 GeneID BioGRID Affinity Capture-MS
    ULK2 BioGRID ATG14 GeneID BioGRID Biochemical Activity
    ULK2 BioGRID ULK1 GeneID BioGRID Phenotypic Enhancement
    ULK2 BioGRID SQSTM1 GeneID BioGRID Reconstituted Complex
    ULK2 BioGRID DIXDC1 GeneID BioGRID Two-hybrid
    ULK2 BioGRID LNX1 GeneID BioGRID Two-hybrid
    ULK2 BioGRID CBX6 GeneID BioGRID Affinity Capture-MS
    ULK2 BioGRID ZNF32 GeneID BioGRID Two-hybrid
    ULK2 BioGRID GABARAPL2 GeneID BioGRID Protein-peptide
    ULK2 BioGRID GABARAP GeneID BioGRID Protein-peptide
    ULK2 Protein LUC7L2 GeneID HPRD None
    ULK2 Protein SYNGAP1 GeneID HPRD None
    ULK2 Protein POLA2 GeneID HPRD None
    ULK2 Protein SETDB1 GeneID HPRD None
    ULK2 Protein NASP GeneID HPRD None
    ULK2 Protein EEF1B2 GeneID HPRD None
    ULK2 BioGRID LUC7L2 GeneID BioGRID Two-hybrid
    ULK2 BioGRID POLA2 GeneID BioGRID Two-hybrid
    ULK2 BioGRID SETDB1 GeneID BioGRID Two-hybrid
    ULK2 BioGRID NASP GeneID BioGRID Two-hybrid
    ULK2 BioGRID SYNGAP1 GeneID BioGRID Reconstituted Complex
    StringDB
    A B experiments database textmining combined score hadb nhadb
    ULK2 ENSG00000267261 0 0 0 161 1 1
    ULK2 SPANXN5 0 0 0 242 1 1
    ULK2 VTI1B 0 0 171 237 1 2
    ULK2 ATM 0 0 124 164 1 1
    ULK2 KCTD12 0 0 730 740 1 1
    ULK2 STX12 0 0 0 158 1 1
    ULK2 PRKAG3 0 0 107 264 1 1
    ULK2 DAP 0 0 184 185 1 2
    ULK2 RGS6 0 0 173 173 1 1
    ULK2 CTSD 0 0 255 381 1 2
    ULK2 TNPO1 270 0 454 585 1 1
    ULK2 PTGR1 0 0 0 225 1 1
    ULK2 FMN1 0 0 63 412 1 1
    ULK2 EGLN2 0 0 0 198 1 1
    ULK2 SLC44A1 0 0 57 157 1 1
    ULK2 IFNA8 0 0 165 165 1 1
    ULK2 SNX30 0 0 0 400 1 1
    ULK2 ATG7 0 0 681 884 1 2
    ULK2 PRKAA2 62 0 229 274 1 2
    ULK2 KIAA0226 0 0 413 431 1 1
    ULK2 DNM1L 0 0 170 256 1 2
    ULK2 SRCAP 0 0 0 150 1 1
    ULK2 WIPI1 0 0 603 806 1 2
    ULK2 PI4KB 0 0 50 253 1 1
    ULK2 RRAGB 0 0 134 268 1 2
    ULK2 PTEN 0 0 294 478 1 2
    ULK2 RAB5C 0 0 0 161 1 1
    ULK2 STX11 0 0 0 172 1 1
    ULK2 CGREF1 0 0 155 173 1 1
    ULK2 ENSG00000260836 0 0 0 165 1 1
    ULK2 SPANXN1 0 0 0 242 1 1
    ULK2 FEZ1 0 0 231 365 1 1
    ULK2 SNTG1 0 0 90 153 1 1
    ULK2 SOGA1 0 0 260 260 1 2
    ULK2 MTA2 237 0 0 242 1 1
    ULK2 GABARAP 59 0 601 860 1 2
    ULK2 STXBP5L 0 0 107 220 1 1
    ULK2 MAPK7 0 0 54 160 1 1
    ULK2 MAPK10 0 0 0 189 1 2
    ULK2 FAM134B 0 0 134 175 1 1
    ULK2 RANBP10 0 0 0 161 1 1
    ULK2 MAPK14 0 0 90 169 1 1
    ULK2 C12orf5 0 0 218 337 1 1
    ULK2 RHOT2 0 0 73 222 1 1
    ULK2 STX3 0 0 0 172 1 1
    ULK2 ATAD2B 0 0 0 155 1 1
    ULK2 TVP23A 0 0 0 177 1 1
    ULK2 AMBRA1 0 0 663 684 1 2
    ULK2 ESR1 0 0 112 154 1 1
    ULK2 OPTN 0 0 335 335 1 2
    ULK2 SIRT1 0 0 260 298 1 2
    ULK2 PTCHD2 0 0 103 159 1 1
    ULK2 FKTN 0 0 0 189 1 1
    ULK2 KIF13B 0 0 0 153 1 1
    ULK2 FUNDC2 0 0 0 183 1 1
    ULK2 NOX1 0 0 0 202 1 1
    ULK2 MAPK8IP3 0 0 74 150 1 1
    ULK2 CTSB 0 0 180 194 1 2
    ULK2 SMCR8 0 800 104 831 1 2
    ULK2 KIF3A 0 0 0 200 1 1
    ULK2 ZNF432 0 0 141 154 1 1
    ULK2 MIB1 0 0 0 186 1 1
    ULK2 IRF1 204 0 0 204 1 1
    ULK2 PRKAG2 272 0 76 330 1 1
    ULK2 AP4E1 0 0 75 178 1 1
    ULK2 TP63 0 0 46 156 1 2
    ULK2 XBP1 0 0 170 171 1 2
    ULK2 CALCOCO2 0 0 450 450 1 2
    ULK2 ATG5 0 0 683 861 1 2
    ULK2 TTLL12 0 0 107 168 1 1
    ULK2 WDFY4 0 0 0 382 1 1
    ULK2 MAP1LC3B 59 0 558 717 1 2
    ULK2 ZFP14 0 0 159 196 1 1
    ULK2 VAMP3 0 0 127 210 1 1
    ULK2 CPEB1 0 0 0 165 1 1
    ULK2 ATG10 0 0 632 714 1 2
    ULK2 UNC5B 0 0 0 161 1 1
    ULK2 TBP 0 0 49 197 1 1
    ULK2 FNIP1 0 0 117 281 1 1
    ULK2 PSMD14 270 0 0 271 1 1
    ULK2 ZBTB21 0 0 103 172 1 1
    ULK2 ULK1 209 900 977 922 1 2
    ULK2 UBE3B 0 0 81 161 1 1
    ULK2 MAP3K12 0 0 57 188 1 1
    ULK2 MLST8 0 900 334 943 1 2
    ULK2 MTUS1 0 0 63 208 1 1
    ULK2 TBC1D25 0 0 151 150 1 1
    ULK2 SNX2 0 0 0 218 1 1
    ULK2 FOXK1 0 0 112 178 1 1
    ULK2 DNM1 0 0 0 156 1 1
    ULK2 HSPA5 0 0 120 168 1 2
    ULK2 TFE3 0 0 141 358 1 1
    ULK2 NRAS 0 0 0 160 1 1
    ULK2 FOXO1 0 0 255 290 1 2
    ULK2 KRAS 0 0 122 255 1 1
    ULK2 TGFB1I1 0 0 0 197 1 1
    ULK2 PPP1R3F 0 0 0 181 1 1
    ULK2 SV2A 0 0 45 155 1 1
    ULK2 ZNF490 0 0 143 156 1 1
    ULK2 DEPTOR 0 600 324 718 1 1
    ULK2 RAB11B 0 0 0 158 1 1
    ULK2 RRAGC 0 0 190 264 1 1
    ULK2 TVP23B 0 0 0 206 1 1
    ULK2 OSBPL11 0 0 112 277 1 1
    ULK2 SEC62 0 0 136 159 1 1
    ULK2 TBKBP1 0 0 168 180 1 1
    ULK2 RRAGD 0 0 167 243 1 1
    ULK2 PPP1R3A 0 0 0 400 1 1
    ULK2 EIF4EBP2 0 0 113 285 1 1
    ULK2 SNX4 0 0 64 237 1 1
    ULK2 EEF2K 0 0 127 192 1 2
    ULK2 BECN1 0 800 757 977 1 2
    ULK2 CHAF1A 0 0 0 154 1 1
    ULK2 PIK3CB 0 0 122 645 1 1
    ULK2 MAPK11 0 0 0 154 1 1
    ULK2 PEX3 0 0 67 296 1 2
    ULK2 IFNA14 0 0 171 171 1 1
    ULK2 ATG12 0 0 686 850 1 2
    ULK2 VPS13A 0 0 0 157 1 1
    ULK2 UFSP2 0 0 125 218 1 1
    ULK2 ZFP28 0 0 134 211 1 1
    ULK2 CTSS 0 0 167 167 1 1
    ULK2 KIF2A 0 0 0 170 1 1
    ULK2 TOPAZ1 0 0 0 343 1 1
    ULK2 UBA2 0 0 0 196 1 1
    ULK2 STX16 0 0 0 192 1 1
    ULK2 PHACTR2 0 0 93 153 1 1
    ULK2 SLC16A5 0 0 81 190 1 1
    ULK2 DIRAS3 0 0 150 209 1 2
    ULK2 VEGFC 0 0 0 192 1 1
    ULK2 HP1BP3 0 0 86 227 1 1
    ULK2 DNAJC24 0 0 0 151 1 1
    ULK2 CYBB 0 0 73 218 1 1
    ULK2 PLEKHM1 0 0 267 278 1 2
    ULK2 ATG101 68 800 827 985 1 2
    ULK2 ATG4D 0 0 509 774 1 2
    ULK2 FCHSD1 0 0 0 157 1 1
    ULK2 PLIN3 0 0 57 267 1 1
    ULK2 SMURF1 0 0 127 204 1 1
    ULK2 SNTB1 0 0 72 170 1 1
    ULK2 CASP3 0 0 241 262 1 2
    ULK2 EIF4B 0 0 61 208 1 1
    ULK2 KIF25 0 0 0 153 1 1
    ULK2 ATG16L1 0 0 662 795 1 2
    ULK2 PIK3CD 0 0 55 347 1 1
    ULK2 IDS 0 0 107 161 1 1
    ULK2 AKAP10 0 0 155 277 1 1
    ULK2 PI4KA 0 0 54 273 1 1
    ULK2 CBX8 0 0 0 162 1 1
    ULK2 YWHAH 237 0 0 264 1 1
    ULK2 GSK3B 0 0 101 166 1 2
    ULK2 PPP6C 0 0 55 173 1 1
    ULK2 CDKN2A 0 0 112 164 1 2
    ULK2 KIF1C 0 0 0 171 1 1
    ULK2 WDR41 0 0 87 186 1 2
    ULK2 RBL2 0 0 0 170 1 1
    ULK2 ESF1 0 0 0 390 1 1
    ULK2 ENSG00000250644 0 0 0 204 1 1
    ULK2 ATG4C 0 0 520 779 1 2
    ULK2 USP8 0 0 118 247 1 1
    ULK2 ACIN1 0 0 0 186 1 1
    ULK2 FOXO3 0 0 358 563 1 2
    ULK2 KIF5B 0 0 0 282 1 1
    ULK2 PCSK9 0 0 0 289 1 1
    ULK2 ENSG00000250232 0 0 202 356 1 1
    ULK2 ENAH 0 0 0 183 1 1
    ULK2 ZBTB24 0 0 82 158 1 1
    ULK2 KBTBD7 0 0 184 201 1 1
    ULK2 ATG3 0 0 662 870 1 2
    ULK2 DNAJB1 0 0 95 208 1 2
    ULK2 ROBO2 0 0 43 152 1 1
    ULK2 ANKRD17 0 0 0 150 1 1
    ULK2 BIRC6 0 0 95 226 1 1
    ULK2 XPNPEP3 0 0 0 303 1 1
    ULK2 RAC2 0 0 96 178 1 1
    ULK2 RAB11A 0 0 148 268 1 1
    ULK2 TOMM20 0 0 164 182 1 1
    ULK2 STX17 0 0 457 529 1 2
    ULK2 UBA3 0 0 0 196 1 1
    ULK2 LYST 0 0 0 193 1 1
    ULK2 TRIT1 0 0 95 250 1 1
    ULK2 RRAGA 0 0 150 283 1 2
    ULK2 MITF 0 0 66 388 1 1
    ULK2 EIF2S1 0 0 134 156 1 2
    ULK2 NTN1 0 0 0 211 1 1
    ULK2 ANPEP 0 0 0 158 1 1
    ULK2 RGS19 0 0 139 200 1 2
    ULK2 NRBF2 0 600 218 673 1 2
    ULK2 PPP1R18 0 0 108 163 1 1
    ULK2 SEC13 0 0 84 161 1 1
    ULK2 TBK1 0 0 269 164 1 2
    ULK2 ATG2B 0 800 457 942 1 2
    ULK2 ZFYVE1 0 0 517 549 1 2
    ULK2 RB1 0 0 75 200 1 2
    ULK2 KIF24 0 0 0 153 1 1
    ULK2 CDKN1B 0 0 150 186 1 2
    ULK2 BOLA2-SMG1P6 0 0 0 284 1 1
    ULK2 VAMP7 0 0 181 271 1 1
    ULK2 BNIP3L 0 0 469 501 1 2
    ULK2 VDAC1 0 0 137 200 1 2
    ULK2 TRRAP 0 0 0 243 1 1
    ULK2 RAB7B 0 0 392 461 1 1
    ULK2 PIK3C2A 0 0 0 243 1 2
    ULK2 TSC2 0 0 458 601 1 2
    ULK2 UBA5 0 0 71 221 1 1
    ULK2 FOXA1 0 0 0 219 1 1
    ULK2 SGK3 0 0 0 173 1 1
    ULK2 CARD14 0 0 155 154 1 1
    ULK2 GARS 0 0 0 167 1 1
    ULK2 RAE1 0 0 0 160 1 1
    ULK2 FEZ2 0 0 0 503 1 1
    ULK2 AKT1 0 0 391 218 1 2
    ULK2 VPS13D 0 0 0 193 1 1
    ULK2 NOX4 0 0 54 165 1 1
    ULK2 SPATA5L1 0 0 0 154 1 1
    ULK2 RAI1 0 0 102 493 1 1
    ULK2 KIF26A 0 0 0 496 1 1
    ULK2 TRHDE 0 0 0 158 1 1
    ULK2 PPP2R4 0 0 123 173 1 1
    ULK2 TMEM74 0 0 340 355 1 2
    ULK2 VMP1 0 0 413 446 1 2
    ULK2 SPATA5 0 0 0 154 1 1
    ULK2 ATF6 0 0 184 183 1 2
    ULK2 ANK3 0 0 0 193 1 1
    ULK2 FOXO4 0 0 108 150 1 1
    ULK2 HSP90AB1 0 0 0 396 1 2
    ULK2 EP400NL 0 0 0 150 1 1
    ULK2 PTPN23 0 0 95 164 1 1
    ULK2 RHOC 0 0 0 174 1 1
    ULK2 PIKFYVE 0 0 159 251 1 1
    ULK2 EIF4EBP1 0 0 252 268 1 1
    ULK2 SIRT4 0 0 134 170 1 1
    ULK2 PINK1 0 0 391 637 1 2
    ULK2 UBQLN1 0 0 138 270 1 2
    ULK2 PHF14 0 0 116 486 1 1
    ULK2 UBA7 0 0 0 196 1 1
    ULK2 WDR81 0 0 0 168 1 1
    ULK2 VEGFB 0 0 49 198 1 1
    ULK2 FBXL17 0 0 81 170 1 1
    ULK2 RNF213 0 0 73 169 1 1
    ULK2 SPEM1 0 0 124 278 1 1
    ULK2 FOXQ1 0 0 0 216 1 1
    ULK2 SYNGAP1 270 0 811 856 1 1
    ULK2 SNX7 0 0 0 400 1 2
    ULK2 DRAM1 0 0 518 528 1 2
    ULK2 FOXK2 0 0 140 197 1 1
    ULK2 RAB7A 0 0 392 571 1 2
    ULK2 MEGF11 0 0 0 173 1 1
    ULK2 TVP23C-CDRT4 0 0 0 206 1 1
    ULK2 KIFC3 0 0 0 153 1 1
    ULK2 GMFB 0 0 81 222 1 1
    ULK2 FNBP1L 0 0 92 188 1 1
    ULK2 SDCBP 0 0 218 218 1 1
    ULK2 PIK3C2G 0 0 67 264 1 1
    ULK2 ERAP2 0 0 0 158 1 1
    ULK2 ATG4B 0 0 610 852 1 2
    ULK2 WDFY3 0 0 282 537 1 2
    ULK2 UVRAG 0 0 654 768 1 2
    ULK2 AGTPBP1 0 0 166 165 1 1
    ULK2 MAPK1 0 0 75 165 1 2
    ULK2 IGF1 0 0 164 163 1 1
    ULK2 RAB23 0 0 46 193 1 2
    ULK2 WDR45 0 0 363 485 1 2
    ULK2 KIF26B 0 0 0 496 1 1
    ULK2 PGK2 0 0 0 189 1 1
    ULK2 RAB1B 0 0 70 355 1 2
    ULK2 VPS36 0 0 57 208 1 1
    ULK2 DDX51 0 0 325 325 1 1
    ULK2 VAPB 0 0 0 160 1 1
    ULK2 CASP2 0 0 92 271 1 1
    ULK2 NBR1 0 0 460 558 1 2
    ULK2 TECPR2 0 0 182 181 1 2
    ULK2 IDH3B 0 0 0 177 1 1
    ULK2 LARS 0 0 155 213 1 1
    ULK2 VPS11 0 0 112 154 1 2
    ULK2 CKAP4 210 0 0 210 1 1
    ULK2 OBSL1 223 0 0 223 1 1
    ULK2 FNIP2 0 0 122 152 1 1
    ULK2 IGBP1 0 0 0 325 1 1
    ULK2 UBL3 0 0 0 173 1 1
    ULK2 CFAP45 0 0 359 359 1 1
    ULK2 FIS1 0 0 95 196 1 2
    ULK2 WIPI2 272 0 595 850 1 2
    ULK2 IDH3A 0 0 0 177 1 1
    ULK2 WDR45B 0 0 293 429 1 1
    ULK2 KIF23 0 0 0 184 1 1
    ULK2 RHEB 0 0 420 670 1 2
    ULK2 DDIT4 0 0 242 241 1 1
    ULK2 KIF22 0 0 0 153 1 1
    ULK2 FOXA2 0 0 0 219 1 1
    ULK2 BAK1 0 0 107 173 1 2
    ULK2 TECPR1 0 0 283 298 1 2
    ULK2 MAD2L2 0 0 213 297 1 1
    ULK2 KIF12 0 0 0 200 1 1
    ULK2 PPP1R3G 0 0 0 181 1 1
    ULK2 ANK2 0 0 0 176 1 1
    ULK2 STX19 0 0 0 172 1 1
    ULK2 PDPK1 0 0 232 194 1 2
    ULK2 MYCBP2 0 0 44 288 1 1
    ULK2 SPANXN3 0 0 0 242 1 1
    ULK2 ATG2A 0 800 464 943 1 2
    ULK2 USP13 0 0 148 180 1 1
    ULK2 KIF14 270 0 0 355 1 1
    ULK2 VPS41 0 0 103 183 1 1
    ULK2 NOX5 0 0 0 216 1 1
    ULK2 SESN1 0 0 321 376 1 2
    ULK2 NTRK1 0 0 108 213 1 1
    ULK2 ACTR10 0 0 0 152 1 1
    ULK2 IRS1 0 0 150 199 1 1
    ULK2 SGK1 0 0 161 205 1 1
    ULK2 HSPA9 0 0 0 156 1 1
    ULK2 PIK3C2B 0 0 83 276 1 1
    ULK2 YWHAQ 0 0 88 231 1 1
    ULK2 PGC 0 0 0 204 1 1
    ULK2 TP53INP2 0 0 120 162 1 2
    ULK2 RPS6KB1 0 0 321 287 1 2
    ULK2 PPP2CA 0 800 0 824 1 1
    ULK2 PRKDC 0 0 0 284 1 2
    ULK2 SPG11 0 0 81 173 1 1
    ULK2 STBD1 0 0 260 260 1 2
    ULK2 EIF4E 0 0 161 241 1 1
    ULK2 TXNRD3NB 0 0 294 294 1 1
    ULK2 PPP1R3B 0 0 0 181 1 1
    ULK2 PRKAA1 131 0 261 342 1 2
    ULK2 HDAC7 0 0 63 160 1 1
    ULK2 ULK3 0 0 603 272 1 2
    ULK2 WDR6 151 0 0 150 1 1
    ULK2 MEGF10 0 0 0 173 1 1
    ULK2 ATR 0 0 0 243 1 1
    ULK2 EPG5 0 0 325 396 1 2
    ULK2 STX2 0 0 0 172 1 1
    ULK2 ELFN2 0 0 120 186 1 1
    ULK2 SIRT6 0 0 142 158 1 1
    ULK2 MORC3 0 0 73 188 1 1
    ULK2 SH3PXD2A 0 0 0 243 1 1
    ULK2 WAC 0 0 134 281 1 1
    ULK2 SNAP47 0 0 75 174 1 1
    ULK2 VPS35 0 0 103 150 1 1
    ULK2 ZNF862 0 0 151 164 1 1
    ULK2 BOLA2B 0 0 0 284 1 1
    ULK2 ATG16L2 0 0 519 604 1 2
    ULK2 DAAM1 0 0 96 161 1 1
    ULK2 LRRC28 0 0 154 239 1 1
    ULK2 SPAST 0 0 73 170 1 1
    ULK2 MAP1LC3C 0 0 501 673 1 2
    ULK2 KIF20A 0 0 0 241 1 1
    ULK2 PPM1G 0 0 0 217 1 1
    ULK2 CASP8 0 0 150 192 1 2
    ULK2 KIF16B 0 0 0 171 1 1
    ULK2 SGK2 0 0 0 168 1 1
    ULK2 CDC37 198 0 0 249 1 1
    ULK2 PPP2R1B 142 0 52 151 1 1
    ULK2 ENPEP 0 0 0 158 1 1
    ULK2 KIF17 0 0 0 153 1 1
    ULK2 CSNK1D 142 0 0 202 1 1
    ULK2 CASP7 0 0 44 169 1 1
    ULK2 PGK1 0 0 0 189 1 2
    ULK2 SEC22C 0 0 150 227 1 1
    ULK2 ZMYM4 0 0 0 357 1 1
    ULK2 SH3PXD2B 0 0 0 243 1 1
    ULK2 ENSG00000267318 0 0 0 165 1 1
    ULK2 LGALS8 0 0 157 168 1 1
    ULK2 DRAM2 0 0 243 259 1 2
    ULK2 KIF4B 0 0 0 213 1 1
    ULK2 ROBO3 0 0 0 150 1 1
    ULK2 RNF183 0 0 102 196 1 1
    ULK2 CYCS 0 0 160 159 1 1
    ULK2 MAPK9 0 0 62 157 1 2
    ULK2 FLCN 0 0 108 192 1 1
    ULK2 ATG4A 0 0 520 818 1 2
    ULK2 ITPR1 0 0 176 212 1 2
    ULK2 TRAF6 0 800 174 834 1 2
    ULK2 TMEM59 0 0 163 241 1 1
    ULK2 KIF6 0 0 0 207 1 1
    ULK2 RAB8B 0 0 72 243 1 2
    ULK2 SH3GLB1 0 0 414 431 1 2
    ULK2 PRKAB2 62 0 71 155 1 1
    ULK2 DICER1 0 0 56 161 1 1
    ULK2 RPTOR 270 900 470 966 1 2
    ULK2 SPRYD3 0 0 0 161 1 1
    ULK2 VARS 0 0 0 173 1 1
    ULK2 DNPEP 0 0 0 254 1 1
    ULK2 ATP6V1D 0 0 0 196 1 1
    ULK2 SESN2 0 0 431 466 1 2
    ULK2 SSFA2 0 0 108 198 1 1
    ULK2 PXN 0 0 51 212 1 1
    ULK2 VPS18 0 0 132 171 1 1
    ULK2 FKBP1A 0 0 244 298 1 2
    ULK2 PPP2CB 0 800 0 824 1 1
    ULK2 HNRNPA2B1 272 0 0 272 1 1
    ULK2 IFNA10 0 0 165 165 1 1
    ULK2 STX1B 0 0 0 255 1 1
    ULK2 RPS6KB2 0 0 82 222 1 2
    ULK2 ZNF594 0 0 155 168 1 1
    ULK2 NSMAF 0 0 0 178 1 1
    ULK2 MAPK8 0 0 232 224 1 2
    ULK2 PRKAB1 273 0 321 521 1 2
    ULK2 MARCH4 0 0 95 151 1 1
    ULK2 AKIP1 0 0 95 233 1 1
    ULK2 CLIP4 0 0 0 157 1 1
    ULK2 SAE1 0 0 0 196 1 1
    ULK2 FUNDC1 0 0 322 503 1 2
    ULK2 KIAA0020 0 0 92 155 1 1
    ULK2 MFN1 0 0 129 225 1 1
    ULK2 IGFBP3 0 0 66 213 1 1
    ULK2 SLC47A1 0 0 94 193 1 1
    ULK2 CPSF6 0 0 0 191 1 1
    ULK2 RSBN1 0 0 107 186 1 1
    ULK2 EI24 0 0 234 248 1 2
    ULK2 VTA1 0 0 63 208 1 1
    ULK2 PRKACB 0 800 0 823 1 1
    ULK2 ENSG00000270024 0 0 0 173 1 1
    ULK2 RGAG1 0 0 0 321 1 1
    ULK2 YWHAE 274 0 0 318 1 1
    ULK2 HOMEZ 0 0 0 181 1 1
    ULK2 VCP 0 0 94 260 1 2
    ULK2 LAMP2 0 0 370 406 1 2
    ULK2 MYRF 0 0 120 175 1 1
    ULK2 EPN2 0 0 82 210 1 1
    ULK2 CENPE 0 0 0 153 1 1
    ULK2 KIF3C 0 0 0 200 1 1
    ULK2 ANKHD1 0 0 0 150 1 1
    ULK2 MIB2 0 0 0 186 1 1
    ULK2 TRIO 0 0 0 160 1 1
    ULK2 DNAJC16 0 0 0 151 1 1
    ULK2 DNAJA3 0 0 0 151 1 1
    ULK2 MAPK12 0 0 0 154 1 1
    ULK2 DIDO1 0 0 67 224 1 1
    ULK2 SNX1 0 0 0 218 1 1
    ULK2 UBA6 0 0 61 213 1 1
    ULK2 KIF11 142 0 0 293 1 1
    ULK2 CEP135 0 0 0 339 1 1
    ULK2 TSC1 0 0 260 373 1 2
    ULK2 DAPK1 0 0 268 175 1 2
    ULK2 ITPR3 0 0 174 210 1 1
    ULK2 PFAS 0 0 0 156 1 1
    ULK2 JUN 0 0 138 200 1 1
    ULK2 RHOT1 0 0 74 202 1 1
    ULK2 AKT1S1 0 600 278 718 1 1
    ULK2 GORASP2 0 0 108 169 1 1
    ULK2 SGSH 0 0 0 198 1 1
    ULK2 STRBP 0 0 75 170 1 1
    ULK2 TEX2 0 0 194 238 1 1
    ULK2 MOCS3 0 0 0 196 1 1
    ULK2 SNAP29 0 0 324 392 1 2
    ULK2 SNCA 0 0 227 226 1 2
    ULK2 RERE 0 0 0 176 1 1
    ULK2 PIK3CG 0 0 122 353 1 1
    ULK2 EPN1 0 0 0 175 1 1
    ULK2 ERBB4 0 0 0 156 1 1
    ULK2 ZNF276 0 0 156 251 1 1
    ULK2 KIF1B 0 0 0 196 1 1
    ULK2 SRF 0 0 0 163 1 1
    ULK2 ATG13 473 900 989 999 1 2
    ULK2 INS 0 0 211 211 1 1
    ULK2 CABYR 0 0 92 306 1 1
    ULK2 ACTB 0 0 180 231 1 1
    ULK2 UHRF1BP1 0 0 84 225 1 1
    ULK2 SIRT3 0 0 136 153 1 2
    ULK2 ULK4 0 0 557 282 1 1
    ULK2 PNPLA5 0 0 95 151 1 1
    ULK2 KEAP1 0 0 150 188 1 2
    ULK2 RANBP9 0 0 0 161 1 1
    ULK2 MAPK3 142 0 124 267 1 2
    ULK2 FAR1 0 0 62 200 1 1
    ULK2 BNIP3 0 0 469 521 1 2
    ULK2 SQSTM1 270 0 562 762 1 2
    ULK2 KIFC2 0 0 0 153 1 1
    ULK2 KIF27 0 0 0 181 1 1
    ULK2 HSP90AA1 0 0 265 370 1 2
    ULK2 PNPLA2 0 0 57 153 1 1
    ULK2 IFNA16 0 0 155 154 1 1
    ULK2 TFEB 0 0 455 494 1 2
    ULK2 KIF5A 0 0 0 282 1 1
    ULK2 ANKHD1-EIF4EBP3 0 0 0 150 1 1
    ULK2 ZMYM2 0 0 0 181 1 1
    ULK2 KIF13A 0 0 0 153 1 1
    ULK2 VPS13C 0 0 0 157 1 1
    ULK2 CLEC16A 0 0 81 156 1 2
    ULK2 MUL1 0 0 154 153 1 2
    ULK2 TP73 0 0 66 174 1 2
    ULK2 SLC44A4 0 0 0 177 1 1
    ULK2 BCL10 0 0 90 155 1 1
    ULK2 RAB1A 0 0 160 417 1 2
    ULK2 HIC2 0 0 108 186 1 1
    ULK2 UMPS 0 0 0 182 1 1
    ULK2 PPP1R3D 0 0 0 181 1 1
    ULK2 DEPDC7 0 0 217 217 1 1
    ULK2 PEAR1 0 0 0 161 1 1
    ULK2 VPS16 0 0 167 177 1 1
    ULK2 ROBO1 0 0 0 150 1 1
    ULK2 HBS1L 142 0 0 168 1 1
    ULK2 GABARAPL1 59 0 662 881 1 2
    ULK2 RALB 0 0 112 233 1 1
    ULK2 ATG9A 0 0 423 828 1 2
    ULK2 IFNA7 0 0 170 169 1 1
    ULK2 RAB24 0 0 325 407 1 2
    ULK2 VPS28 0 0 0 188 1 1
    ULK2 EIF4G1 0 0 134 189 1 2
    ULK2 MOCS2 0 0 93 155 1 1
    ULK2 RHOA 0 0 74 248 1 1
    ULK2 HSPA8 0 0 244 271 1 2
    ULK2 SNX8 0 0 0 218 1 1
    ULK2 STX4 0 0 0 172 1 1
    ULK2 STX1A 0 0 0 235 1 1
    ULK2 UBE2N 0 0 0 357 1 1
    ULK2 MAN2C1 0 0 0 277 1 1
    ULK2 TRAPPC8 0 0 164 353 1 1
    ULK2 ZNF606 0 0 155 220 1 1
    ULK2 MTMR3 0 0 143 243 1 2
    ULK2 ADNP2 0 0 113 168 1 1
    ULK2 MTOR 0 900 687 993 1 2
    ULK2 SMARCAD1 0 0 0 175 1 1
    ULK2 TVP23C 0 0 0 206 1 1
    ULK2 PIRT 0 0 145 164 1 1
    ULK2 PIK3C3 0 600 768 961 1 2
    ULK2 RAB12 0 0 0 169 1 2
    ULK2 RPS6 0 0 140 159 1 1
    ULK2 UNC5C 0 0 0 161 1 1
    ULK2 BEND6 0 0 194 315 1 1
    ULK2 FOXO6 0 0 150 208 1 1
    ULK2 NAE1 0 0 0 196 1 1
    ULK2 RAB5A 0 0 288 377 1 2
    ULK2 ZMYM3 0 0 0 181 1 1
    ULK2 NR1H3 0 0 0 180 1 1
    ULK2 RAB5B 0 0 0 161 1 1
    ULK2 HIF1A 0 0 184 195 1 2
    ULK2 SEC16B 0 0 112 272 1 2
    ULK2 SIRT5 0 0 134 151 1 1
    ULK2 BAG3 0 0 113 152 1 2
    ULK2 PPP2R2D 151 0 0 188 1 1
    ULK2 SEC24B 0 0 154 195 1 1
    ULK2 MAPK13 0 0 0 154 1 1
    ULK2 CLN3 0 0 126 213 1 2
    ULK2 MFN2 0 0 193 292 1 2
    ULK2 IFNA4 0 0 166 165 1 1
    ULK2 PEX13 0 0 0 171 1 1
    ULK2 HRAS 0 0 141 271 1 1
    ULK2 MAP1LC3A 0 0 508 821 1 2
    ULK2 ERAP1 0 0 0 158 1 1
    ULK2 PRKAG1 128 0 45 171 1 1
    ULK2 DNM3 0 0 0 157 1 1
    ULK2 PASK 0 0 0 183 1 1
    ULK2 KIF3B 0 0 0 200 1 1
    ULK2 ZNF500 0 0 134 237 1 1
    ULK2 PIK3R4 0 600 664 920 1 2
    ULK2 FYCO1 0 0 310 334 1 2
    ULK2 RAB33B 0 0 107 197 1 2
    ULK2 CBX6 270 0 0 420 1 1
    ULK2 BCL2L1 0 0 292 297 1 2
    ULK2 FCHSD2 0 0 0 157 1 1
    ULK2 MAPK8IP1 0 0 66 161 1 1
    ULK2 GAPDH 0 0 166 188 1 2
    ULK2 ATIC 0 0 48 192 1 2
    ULK2 ATG14 270 800 710 970 1 2
    ULK2 LARS2 0 0 144 176 1 1
    ULK2 PPP1R3E 0 0 0 181 1 1
    ULK2 CCDC85A 0 0 112 197 1 1
    ULK2 KIF1A 0 0 0 171 1 1
    ULK2 MAP2K7 0 0 105 169 1 1
    ULK2 DACT1 0 0 0 336 1 1
    ULK2 FKBP8 0 0 209 372 1 1
    ULK2 GABARAPL2 59 0 632 840 1 2
    ULK2 SMG1 0 0 0 284 1 1
    ULK2 TRAK1 0 0 82 321 1 1
    ULK2 PRR5 0 0 204 222 1 1
    ULK2 LRSAM1 0 0 166 172 1 2
    ULK2 EP400 0 0 0 150 1 1
    ULK2 KIF2B 0 0 0 153 1 1
    ULK2 PRKACA 0 800 0 823 1 1
    ULK2 CREB1 142 0 73 170 1 1
    ULK2 NOX3 0 0 0 286 1 1
    ULK2 SH3GLB2 0 0 193 211 1 1
    ULK2 FBXO32 0 0 146 164 1 2
    ULK2 NPEPPS 0 0 0 158 1 1
    ULK2 STARD9 0 0 0 153 1 1
    ULK2 MAP1LC3B2 0 0 129 433 1 2
    ULK2 USP43 0 0 0 168 1 1
    ULK2 ZKSCAN3 0 0 193 205 1 2
    ULK2 KIF19 0 0 0 153 1 1
    ULK2 SIRT2 0 0 135 152 1 2
    ULK2 CTSE 0 0 0 204 1 1
    ULK2 UBA1 0 0 0 196 1 1
    ULK2 TRAK2 0 0 87 260 1 1
    ULK2 C9orf72 0 800 134 826 1 2
    ULK2 FLNA 210 0 0 233 1 1
    ULK2 ZBTB39 0 0 160 204 1 1
    ULK2 KIFC1 0 0 0 153 1 1
    ULK2 SEC16A 270 0 385 580 1 2
    ULK2 PARK7 0 0 142 201 1 1
    ULK2 TAX1BP1 0 0 236 240 1 2
    ULK2 VPS39 0 0 151 188 1 1
    ULK2 LNPEP 0 0 0 158 1 1
    ULK2 PLEKHA5 0 0 94 187 1 1
    ULK2 KIF20B 0 0 0 403 1 1
    ULK2 CALCOCO1 0 0 171 190 1 1
    ULK2 RB1CC1 130 900 988 999 1 2
    ULK2 OPA1 0 0 70 160 1 1
    ULK2 MFF 0 0 141 176 1 1
    ULK2 BOLA2 0 0 0 284 1 1
    ULK2 REV1 0 0 51 191 1 1
    ULK2 SYNJ1 0 0 0 165 1 1
    ULK2 SEC24C 0 0 167 179 1 1
    ULK2 STK11 0 0 325 189 1 2
    ULK2 PARK2 0 0 284 428 1 1
    ULK2 ILK 0 0 54 215 1 1
    ULK2 KIF18A 0 0 0 153 1 1
    ULK2 IRGM 0 0 325 325 1 2
    ULK2 MYC 0 0 172 203 1 2
    ULK2 IDH3G 0 0 0 177 1 1
    ULK2 PPP5C 151 0 0 199 1 1
    ULK2 PLCL1 0 0 134 238 1 1
    ULK2 PPARGC1A 0 0 141 178 1 1
    ULK2 KIF21B 0 0 0 181 1 1
    ULK2 VARS2 0 0 0 173 1 1
    ULK2 KIF21A 0 0 0 181 1 1
    ULK2 KIF2C 0 0 0 153 1 1
    ULK2 KALRN 0 0 0 233 1 1
    ULK2 PPP1R3C 0 0 0 181 1 1
    ULK2 UNC5A 0 0 0 161 1 1
    ULK2 KIF9 0 0 0 200 1 1
    ULK2 RICTOR 0 0 323 392 1 2
    ULK2 ENSG00000261832 0 0 134 220 1 1
    ULK2 NAPSA 0 0 0 204 1 1
    ULK2 USP10 0 0 103 193 1 2
    ULK2 PIK3CA 0 0 107 368 1 2
    ULK2 VAPA 0 0 45 204 1 1
    ULK2 MRPS35 0 0 0 154 1 1
    ULK2 ANP32E 0 0 95 189 1 1
    ULK2 KIF18B 0 0 0 153 1 1
    ULK2 HDAC6 0 0 243 362 1 2
    ULK2 VAMP8 0 0 287 320 1 2
    ULK2 HGS 0 0 181 338 1 2
    ULK2 CYBA 0 0 0 175 1 1
    ULK2 KIF7 0 0 0 181 1 1
    ULK2 CAMKK2 0 0 235 167 1 2
    ULK2 KIF4A 0 0 0 227 1 1
    ULK2 SCOC 0 0 141 224 1 2
    ULK2 MCOLN1 0 0 146 176 1 1
    ULK2 RAB8A 0 0 53 166 1 2
    ULK2 TRIL 0 0 92 157 1 1
    ULK2 ERN1 0 0 179 153 1 2
    ULK2 CD300C 0 0 469 469 1 1
    ULK2 POTEG 0 0 145 172 1 1
    ULK2 RBBP6 0 0 66 165 1 1
    ULK2 EIF2AK4 0 0 149 159 1 1
    ULK2 NR1H2 0 0 0 180 1 1
    ULK2 KIF5C 0 0 0 300 1 1
    ULK2 TGM2 0 0 113 236 1 1
    ULK2 TP53 0 0 401 401 1 2
    ULK2 HTT 0 0 244 477 1 1
    ULK2 EGFR 0 0 128 169 1 1
    ULK2 CFLAR 0 0 95 200 1 1
    ULK2 MAP3K13 0 0 66 171 1 1
    ULK2 LAMP1 0 0 325 429 1 2
    ULK2 FADD 0 0 108 160 1 2
    ULK2 SPANXN2 0 0 0 242 1 1
    ULK2 RBL1 0 0 0 170 1 1
    ULK2 PFKFB2 0 0 127 170 1 1
    ULK2 KIF15 0 0 0 200 1 1
    ULK2 PRKX 0 0 0 152 1 1
    ULK2 STK36 0 0 470 265 1 1
    ULK2 BCAS3 0 0 0 234 1 2
    ULK2 PRKACG 0 800 0 823 1 1
    ULK2 MAP1A 0 0 344 381 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0004676 Molecular Function 3-phosphoinositide-dependent protein kinase activity enables IEA
    GO:0004679 Molecular Function AMP-activated protein kinase activity enables IEA
    GO:0005524 Molecular Function ATP binding enables IEA
    GO:0004677 Molecular Function DNA-dependent protein kinase activity enables IEA
    GO:0072518 Molecular Function Rho-dependent protein serine/threonine kinase activity enables IEA
    GO:0004694 Molecular Function eukaryotic translation initiation factor 2alpha kinase activity enables IEA
    GO:0044024 Molecular Function histone H2AS1 kinase activity enables IEA
    GO:0072371 Molecular Function histone H2AS121 kinase activity enables IEA
    GO:1990244 Molecular Function histone H2AT120 kinase activity enables IEA
    GO:0035979 Molecular Function histone H2AXS139 kinase activity enables IEA
    GO:0044025 Molecular Function histone H2BS14 kinase activity enables IEA
    GO:0140823 Molecular Function histone H2BS36 kinase activity enables IEA
    GO:0035175 Molecular Function histone H3S10 kinase activity enables IEA
    GO:0044022 Molecular Function histone H3S28 kinase activity enables IEA
    GO:0140855 Molecular Function histone H3S57 kinase activity enables IEA
    GO:0035402 Molecular Function histone H3T11 kinase activity enables IEA
    GO:0072354 Molecular Function histone H3T3 kinase activity enables IEA
    GO:0140857 Molecular Function histone H3T45 kinase activity enables IEA
    GO:0035403 Molecular Function histone H3T6 kinase activity enables IEA
    GO:0044023 Molecular Function histone H4S1 kinase activity enables IEA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0106310 Molecular Function protein serine kinase activity enables IEA
    GO:0004674 Molecular Function protein serine/threonine kinase activity enables IBA
    GO:0004674 Molecular Function protein serine/threonine kinase activity enables IDA
    GO:0004711 Molecular Function ribosomal protein S6 kinase activity enables IEA
    GO:0000045 Biological Process autophagosome assembly involved_in IBA
    GO:0006914 Biological Process autophagy involved_in IDA
    GO:0006914 Biological Process autophagy involved_in IGI
    GO:0048675 Biological Process axon extension involved_in IBA
    GO:0007411 Biological Process axon guidance involved_in IEA
    GO:0006338 Biological Process chromatin remodeling involved_in IEA
    GO:0048668 Biological Process collateral sprouting involved_in IEA
    GO:0000423 Biological Process mitophagy involved_in IBA
    GO:0048671 Biological Process negative regulation of collateral sprouting involved_in IBA
    GO:0034727 Biological Process piecemeal microautophagy of the nucleus involved_in IBA
    GO:0046777 Biological Process protein autophosphorylation involved_in IDA
    GO:0008104 Biological Process protein localization involved_in IEA
    GO:0010506 Biological Process regulation of autophagy involved_in IBA
    GO:0042594 Biological Process response to starvation involved_in IBA
    GO:0042594 Biological Process response to starvation involved_in ISS
    GO:0061709 Biological Process reticulophagy involved_in IBA
    GO:0007165 Biological Process signal transduction involved_in IEA
    GO:0160038 Biological Process somatic sensory system development involved_in IEA
    GO:0005776 Cellular Component autophagosome is_active_in IBA
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0030659 Cellular Component cytoplasmic vesicle membrane located_in IEA
    GO:0005829 Cellular Component cytosol is_active_in IBA
    GO:0000407 Cellular Component phagophore assembly site is_active_in IBA
    GO:0034045 Cellular Component phagophore assembly site membrane is_active_in IBA
    GO:0034045 Cellular Component phagophore assembly site membrane located_in IDA
    Pathways
    Name DB ID
    p53 transcriptional gene network (WP4963) WikiPathways WP4963_r122690
    Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
    Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
    Host-pathogen interaction of human coronaviruses - autophagy (WP4863) WikiPathways WP4863_r124639
    Nanoparticle triggered autophagic cell death (WP2509) WikiPathways WP2509_r101755
    Malignant pleural mesothelioma (WP5087) WikiPathways WP5087_r122659
    Target of rapamycin signaling (WP1471) WikiPathways WP1471_r123616
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XM_047437147 1 mRNA transcript variant X2 NC_000017 Reference
    NM_001142610 2 mRNA transcript variant 2 NC_000017 Reference
    NM_014683 4 mRNA transcript variant 1 NC_000017 Reference
    XM_017025425 3 mRNA transcript variant X1 NC_000017 Reference
    XM_047437148 1 mRNA transcript variant X3 NC_000017 Reference