TP53INP1

tumor protein p53 inducible nuclear protein 1
General Information
Name tumor protein p53 inducible nuclear protein 1
Alias
  • tumor protein p53-inducible nuclear protein 1
  • p53-dependent damage-inducible nuclear protein 1
  • p53-inducible p53DINP1
  • stress-induced protein
Synonyms DKFZp434M1317 FLJ22139 P53DINP1 SIP TP53INP1A TP53INP1B Teap TP53DINP1 p53DINP1
Gene_family None
organism Homo sapiens
entrez_id 94241
location 8q22.1
transcript_count 3
exon_count 6
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of DNA-templated transcription; and positive regulation of autophagy. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Mar 2025]
      Stringdb Tumor protein p53-inducible nuclear protein 1; Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxyg [...]
      nextProt Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    TP53INP1 BioGRID ASPM GeneID BioGRID Affinity Capture-MS
    TP53INP1 BioGRID ZBTB9 GeneID BioGRID Affinity Capture-MS
    TP53INP1 BioGRID TBC1D4 GeneID BioGRID Affinity Capture-MS
    TP53INP1 BioGRID MAP1LC3C GeneID BioGRID Two-hybrid
    TP53INP1 BioGRID YPEL3 GeneID BioGRID Two-hybrid
    TP53INP1 BioGRID SEC22A GeneID BioGRID Two-hybrid
    TP53INP1 BioGRID GABARAPL1 GeneID BioGRID Two-hybrid
    TP53INP1 BioGRID GABARAPL2 GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
    TP53INP1 BioGRID GABARAP GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
    TP53INP1 BioGRID UNC119 GeneID BioGRID Two-hybrid
    TP53INP1 BioGRID HNRNPL GeneID BioGRID Affinity Capture-RNA
    TP53INP1 BioGRID KAT14 GeneID BioGRID Affinity Capture-MS
    TP53INP1 BioGRID YEATS2 GeneID BioGRID Affinity Capture-MS
    TP53INP1 BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-Western; FRET
    TP53INP1 BioGRID SQSTM1 GeneID BioGRID FRET
    TP53INP1 BioGRID ELAVL1 GeneID BioGRID Affinity Capture-RNA
    TP53INP1 Protein HIPK2 GeneID HPRD None
    TP53INP1 Protein TP53 GeneID HPRD None
    TP53INP1 BioGRID TP53 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TP53INP1 BioGRID HIPK2 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TP53INP1 Nucleotide E2F4 GeneID BIND E2F4 interacts with the TP53INP1 promoter.
    TP53INP1 Nucleotide E2F3 GeneID BIND E2F3 interacts with the TP53INP1 promoter.
    TP53INP1 Nucleotide E2F2 GeneID BIND E2F2 interacts with the TP53INP1 promoter.
    TP53INP1 Nucleotide E2F1 GeneID BIND E2F1 interacts with the TP53INP1 promoter.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TP53INP1 CDC25A 0 0 205 211 1 1
    TP53INP1 RARRES1 0 0 141 164 1 1
    TP53INP1 LPIN1 0 0 188 228 1 2
    TP53INP1 IKBIP 0 0 112 348 1 1
    TP53INP1 RXRB 0 0 0 185 1 1
    TP53INP1 GLIS3 0 0 134 169 1 1
    TP53INP1 RASL11A 0 0 115 152 1 1
    TP53INP1 PRKCSH 0 0 0 189 1 1
    TP53INP1 BECN1 0 0 182 181 1 2
    TP53INP1 AP1S1 0 0 61 158 1 1
    TP53INP1 INTS8 0 0 161 224 1 1
    TP53INP1 CDKN2C 0 0 113 308 1 1
    TP53INP1 PMAIP1 0 0 294 294 1 1
    TP53INP1 SLC46A3 0 0 113 178 1 1
    TP53INP1 CDKN2B 0 0 146 180 1 1
    TP53INP1 CERS6 0 0 70 179 1 1
    TP53INP1 DUSP1 0 0 155 173 1 1
    TP53INP1 IZUMO2 0 0 150 281 1 1
    TP53INP1 TIAF1 0 0 304 304 1 1
    TP53INP1 SMYD2 0 0 261 261 1 1
    TP53INP1 HSPA5 0 0 261 261 1 2
    TP53INP1 KRAS 0 0 224 224 1 1
    TP53INP1 FOXO1 0 0 181 198 1 2
    TP53INP1 BBX 0 0 73 150 1 1
    TP53INP1 IRAK3 0 0 57 152 1 1
    TP53INP1 RXRA 0 0 0 185 1 1
    TP53INP1 GNG5 0 0 70 213 1 1
    TP53INP1 PON1 0 0 307 307 1 1
    TP53INP1 OSBPL11 0 0 103 312 1 1
    TP53INP1 CEBPB 0 0 172 171 1 1
    TP53INP1 CDC123 0 0 369 369 1 1
    TP53INP1 MAP3K10 0 0 102 155 1 1
    TP53INP1 TP53TG3B 0 0 233 232 1 1
    TP53INP1 CRYAB 0 0 124 178 1 1
    TP53INP1 MTCH2 0 0 104 244 1 1
    TP53INP1 CCNG1 0 0 336 465 1 1
    TP53INP1 EPB42 0 0 93 155 1 1
    TP53INP1 FAT4 0 0 81 183 1 1
    TP53INP1 CDC34 0 0 53 151 1 1
    TP53INP1 GAS8 0 0 66 279 1 1
    TP53INP1 CDKN2A 0 0 290 290 1 2
    TP53INP1 MGP 0 0 327 327 1 1
    TP53INP1 LRRC41 0 0 73 151 1 1
    TP53INP1 CUL3 0 0 415 415 1 1
    TP53INP1 JAZF1 0 0 315 333 1 1
    TP53INP1 ZNF302 0 0 178 177 1 1
    TP53INP1 MRPL36 0 0 0 190 1 1
    TP53INP1 RBL2 0 0 74 171 1 1
    TP53INP1 SESTD1 0 0 90 230 1 1
    TP53INP1 TP53TG3D 0 0 233 232 1 1
    TP53INP1 UFSP2 0 0 90 230 1 1
    TP53INP1 TNFRSF10B 0 0 260 266 1 1
    TP53INP1 RFX7 0 0 74 242 1 1
    TP53INP1 NOTCH2 0 0 166 176 1 1
    TP53INP1 PSMA5 0 0 108 163 1 1
    TP53INP1 DIRAS3 0 0 66 177 1 2
    TP53INP1 LURAP1 0 0 123 323 1 1
    TP53INP1 EDA2R 0 0 120 226 1 1
    TP53INP1 CREBRF 0 0 0 264 1 1
    TP53INP1 BZW1 0 0 95 341 1 1
    TP53INP1 KLF14 0 0 321 350 1 1
    TP53INP1 ESRRG 0 0 48 187 1 1
    TP53INP1 DTYMK 0 0 66 321 1 1
    TP53INP1 HNRNPL 270 0 0 270 1 1
    TP53INP1 DMBX1 0 0 69 309 1 1
    TP53INP1 TRIB3 0 0 150 208 1 1
    TP53INP1 ZFAND3 0 0 166 185 1 1
    TP53INP1 CASP3 0 0 380 393 1 2
    TP53INP1 PRM2 0 0 389 388 1 1
    TP53INP1 NQO1 0 0 137 163 1 1
    TP53INP1 AGO1 0 0 66 159 1 1
    TP53INP1 E2F5 0 0 181 204 1 1
    TP53INP1 PMEPA1 0 0 97 156 1 1
    TP53INP1 ZNF593 0 0 134 267 1 1
    TP53INP1 PTEN 0 0 372 385 1 2
    TP53INP1 ID3 0 0 150 181 1 1
    TP53INP1 VEGFA 0 0 167 167 1 1
    TP53INP1 ARID2 0 0 167 185 1 1
    TP53INP1 GABARAP 497 0 108 609 1 2
    TP53INP1 BAG1 0 0 167 231 1 2
    TP53INP1 TP53BP2 0 0 241 320 1 1
    TP53INP1 E2F3 0 0 162 184 1 1
    TP53INP1 WSB2 0 0 0 188 1 1
    TP53INP1 ENSG00000205457 0 0 233 232 1 1
    TP53INP1 IL21R 0 0 60 160 1 1
    TP53INP1 RFWD3 0 0 123 185 1 1
    TP53INP1 MAPK14 0 0 164 291 1 1
    TP53INP1 C12orf5 0 0 322 321 1 1
    TP53INP1 NFKBIA 0 0 134 262 1 1
    TP53INP1 SUSD5 0 0 103 224 1 1
    TP53INP1 CLPB 0 0 181 181 1 1
    TP53INP1 TACSTD2 0 0 0 364 1 1
    TP53INP1 MDM4 0 0 184 221 1 1
    TP53INP1 SEPT3 0 0 61 314 1 1
    TP53INP1 ZNF469 0 0 70 169 1 1
    TP53INP1 ATM 0 0 293 293 1 1
    TP53INP1 GNPDA2 0 0 95 191 1 1
    TP53INP1 UPP2 0 0 0 205 1 1
    TP53INP1 TAF1L 0 0 54 150 1 1
    TP53INP1 DAPK2 0 0 167 347 1 2
    TP53INP1 STRADB 0 0 73 161 1 1
    TP53INP1 HHEX 0 0 276 276 1 1
    TP53INP1 ASPM 184 0 0 184 1 1
    TP53INP1 UBE2S 0 0 124 221 1 1
    TP53INP1 PPP3R1 0 0 151 150 1 1
    TP53INP1 GDF15 0 0 335 335 1 1
    TP53INP1 BTG2 0 0 342 375 1 1
    TP53INP1 RXRG 0 0 0 188 1 1
    TP53INP1 CCAR1 0 0 103 175 1 1
    TP53INP1 GDF5 0 0 0 154 1 1
    TP53INP1 AQP9 0 0 49 153 1 1
    TP53INP1 SERPINB5 0 0 163 163 1 1
    TP53INP1 TIMP2 0 0 141 234 1 1
    TP53INP1 MAP1LC3B 0 0 425 498 1 2
    TP53INP1 HSPB1 0 0 282 297 1 1
    TP53INP1 HSPB2 0 0 262 262 1 1
    TP53INP1 YBX3 0 0 43 154 1 1
    TP53INP1 HERPUD2 0 0 113 153 1 1
    TP53INP1 TERT 0 0 123 197 1 1
    TP53INP1 TSPAN8 0 0 181 181 1 1
    TP53INP1 SPRED2 0 0 62 265 1 1
    TP53INP1 OSBPL9 0 0 94 182 1 1
    TP53INP1 QARS 0 0 48 152 1 1
    TP53INP1 MAP9 0 0 112 166 1 1
    TP53INP1 PLK3 0 0 269 270 1 1
    TP53INP1 KLHL42 0 0 183 183 1 1
    TP53INP1 TUSC2 0 0 166 213 1 1
    TP53INP1 SKIL 0 0 129 151 1 1
    TP53INP1 ALDH4A1 0 0 193 193 1 1
    TP53INP1 ZBTB4 0 0 218 218 1 1
    TP53INP1 PTP4A1 0 0 108 210 1 1
    TP53INP1 ENSG00000205457 0 0 233 232 1 1
    TP53INP1 STMN1 0 0 112 189 1 1
    TP53INP1 SEL1L 0 0 194 324 1 1
    TP53INP1 ESR1 0 0 181 273 1 1
    TP53INP1 PPP1CA 0 0 167 310 1 1
    TP53INP1 MAP3K5 0 0 165 165 1 1
    TP53INP1 RNH1 0 0 143 170 1 1
    TP53INP1 SMAD7 0 0 144 197 1 1
    TP53INP1 GNA11 0 0 0 153 1 1
    TP53INP1 SIRT1 0 0 246 262 1 2
    TP53INP1 PGM2L1 0 0 0 161 1 1
    TP53INP1 MCL1 0 0 264 264 1 2
    TP53INP1 RGS2 0 0 166 258 1 1
    TP53INP1 MYBL2 0 0 72 200 1 1
    TP53INP1 SASH3 0 0 83 486 1 1
    TP53INP1 EPHX1 0 0 49 162 1 1
    TP53INP1 HIPK2 270 600 699 904 1 1
    TP53INP1 TP63 0 0 181 186 1 2
    TP53INP1 XBP1 0 0 211 211 1 2
    TP53INP1 LGR5 0 0 120 214 1 1
    TP53INP1 HTATIP2 0 0 164 163 1 1
    TP53INP1 ATG5 0 0 140 173 1 2
    TP53INP1 C2CD4B 0 0 223 223 1 1
    TP53INP1 CACUL1 0 0 112 167 1 1
    TP53INP1 STARD13 0 0 162 161 1 1
    TP53INP1 HMG20A 0 0 103 264 1 1
    TP53INP1 AEN 0 0 112 152 1 1
    TP53INP1 CASP2 0 0 154 153 1 1
    TP53INP1 ADAMTS9 0 0 264 277 1 1
    TP53INP1 NBR1 0 0 108 152 1 2
    TP53INP1 PRC1 0 0 66 235 1 1
    TP53INP1 TNF 0 0 193 193 1 1
    TP53INP1 RSC1A1 0 0 0 150 1 1
    TP53INP1 COL8A1 0 0 46 194 1 1
    TP53INP1 C8orf4 0 0 165 348 1 1
    TP53INP1 STIP1 0 0 235 235 1 1
    TP53INP1 SLC7A11 0 0 181 231 1 1
    TP53INP1 ITCH 0 0 124 205 1 1
    TP53INP1 PPP1R15A 0 0 181 181 1 2
    TP53INP1 ABI2 0 0 69 237 1 1
    TP53INP1 TP53TG5 0 0 150 284 1 1
    TP53INP1 GLS2 0 0 213 214 1 1
    TP53INP1 ST7L 0 0 137 178 1 1
    TP53INP1 ICMT 0 0 66 228 1 1
    TP53INP1 RELB 0 0 83 176 1 2
    TP53INP1 DRAM1 0 0 231 259 1 2
    TP53INP1 FGF2 0 0 105 160 1 1
    TP53INP1 SPOCK1 0 0 81 174 1 1
    TP53INP1 FKBP1C 0 0 277 277 1 1
    TP53INP1 PROX1 0 0 156 244 1 1
    TP53INP1 BMF 0 0 136 201 1 1
    TP53INP1 CCND2 0 0 163 177 1 1
    TP53INP1 SPRY2 0 0 202 202 1 1
    TP53INP1 TNFAIP3 0 0 167 185 1 1
    TP53INP1 ACER2 0 0 194 249 1 1
    TP53INP1 EDEM1 0 0 155 173 1 2
    TP53INP1 ALDH9A1 0 0 136 160 1 1
    TP53INP1 SOCS1 0 0 284 284 1 1
    TP53INP1 EPB41L1 0 0 58 163 1 1
    TP53INP1 GADD45A 0 0 329 344 1 1
    TP53INP1 PFKFB4 0 0 210 210 1 1
    TP53INP1 ESRRB 0 0 0 165 1 1
    TP53INP1 ATF3 0 0 218 242 1 1
    TP53INP1 TCEAL7 0 0 89 168 1 1
    TP53INP1 SESN1 0 0 423 447 1 2
    TP53INP1 FDXR 0 0 358 362 1 1
    TP53INP1 EGR2 0 0 170 189 1 1
    TP53INP1 HSPA9 0 0 170 181 1 1
    TP53INP1 SGK1 0 0 155 197 1 1
    TP53INP1 IRS1 0 0 181 195 1 1
    TP53INP1 DMTF1 0 0 145 309 1 1
    TP53INP1 TP53INP2 0 0 562 160 1 2
    TP53INP1 PPP2CA 0 0 74 150 1 1
    TP53INP1 GAMT 0 0 262 262 1 1
    TP53INP1 PGR 0 0 92 194 1 1
    TP53INP1 TP53I13 0 0 211 239 1 1
    TP53INP1 CCND1 0 0 265 265 1 1
    TP53INP1 ARAP1 0 0 402 402 1 1
    TP53INP1 DDB2 0 0 203 203 1 1
    TP53INP1 RRM2B 0 0 282 297 1 1
    TP53INP1 HOXD8 0 0 73 201 1 1
    TP53INP1 PLAGL2 0 0 47 191 1 1
    TP53INP1 ABCG2 0 0 89 183 1 1
    TP53INP1 GRAMD4 0 0 0 189 1 1
    TP53INP1 BCL2L2 0 0 181 181 1 1
    TP53INP1 DDIT4 0 0 460 471 1 1
    TP53INP1 MYB 0 0 124 166 1 1
    TP53INP1 BAK1 0 0 292 317 1 2
    TP53INP1 FEM1B 0 0 245 277 1 1
    TP53INP1 LIN28A 0 0 108 163 1 1
    TP53INP1 TP53I3 0 0 391 390 1 1
    TP53INP1 DEK 0 0 0 256 1 1
    TP53INP1 CANX 0 0 156 155 1 2
    TP53INP1 TXN 0 0 180 179 1 1
    TP53INP1 HRK 0 0 152 182 1 1
    TP53INP1 DDI2 0 0 95 197 1 1
    TP53INP1 TSPAN14 0 0 161 253 1 1
    TP53INP1 MCM7 0 0 291 290 1 1
    TP53INP1 OSBPL10 0 0 0 199 1 1
    TP53INP1 DGKB 0 0 194 194 1 1
    TP53INP1 HMOX1 0 0 246 245 1 2
    TP53INP1 LIN28B 0 0 122 154 1 1
    TP53INP1 TCHP 0 0 301 301 1 1
    TP53INP1 RB1 0 0 98 154 1 2
    TP53INP1 PRKCD 270 0 707 777 1 2
    TP53INP1 CDKN1B 0 0 240 258 1 2
    TP53INP1 ARID3B 0 0 151 150 1 1
    TP53INP1 DDX20 0 0 95 194 1 1
    TP53INP1 PTPDC1 0 0 95 189 1 1
    TP53INP1 BNIP3L 0 0 212 229 1 2
    TP53INP1 CDKAL1 0 0 340 340 1 1
    TP53INP1 TGFB1 0 0 305 305 1 1
    TP53INP1 MC4R 0 0 94 156 1 1
    TP53INP1 PPM1D 0 0 457 469 1 1
    TP53INP1 TP53I11 0 0 261 368 1 1
    TP53INP1 SPRED1 0 0 71 164 1 1
    TP53INP1 FOXO3 0 0 323 392 1 2
    TP53INP1 SLC24A4 0 0 124 178 1 1
    TP53INP1 ZBED3 0 0 406 406 1 1
    TP53INP1 HNF4A 0 0 134 198 1 1
    TP53INP1 ZFAND6 0 0 460 485 1 1
    TP53INP1 CAMK2D 178 0 0 177 1 1
    TP53INP1 DNAJB1 0 0 325 325 1 2
    TP53INP1 SLC30A8 0 0 257 274 1 1
    TP53INP1 HOXB6 0 0 53 151 1 1
    TP53INP1 BIRC6 0 0 74 184 1 1
    TP53INP1 CDKN3 0 0 170 169 1 1
    TP53INP1 GAS2 0 0 74 234 1 1
    TP53INP1 ITGB1BP1 0 0 57 202 1 1
    TP53INP1 MMP23B 0 0 0 286 1 1
    TP53INP1 ZNF652 0 0 167 167 1 1
    TP53INP1 CERS4 0 0 49 161 1 1
    TP53INP1 WWOX 0 0 48 308 1 1
    TP53INP1 CCNG2 0 0 182 187 1 1
    TP53INP1 BIRC5 0 0 155 173 1 2
    TP53INP1 PINK1 0 0 154 153 1 2
    TP53INP1 HMGA2 0 0 293 293 1 1
    TP53INP1 ERBB2 0 0 167 173 1 2
    TP53INP1 BBC3 0 0 451 451 1 1
    TP53INP1 PHYKPL 0 0 0 189 1 1
    TP53INP1 PRKRA 0 0 180 356 1 1
    TP53INP1 FUCA1 0 0 0 189 1 1
    TP53INP1 CCNE2 0 0 285 284 1 1
    TP53INP1 SUMO1 0 0 120 164 1 1
    TP53INP1 TPD52 0 0 162 179 1 1
    TP53INP1 CIRBP 0 0 212 212 1 1
    TP53INP1 CARD8 0 0 167 167 1 1
    TP53INP1 RBAK 0 0 184 183 1 1
    TP53INP1 MXD1 0 0 107 174 1 1
    TP53INP1 INPP5D 0 0 308 307 1 1
    TP53INP1 PPARG 0 0 206 307 1 1
    TP53INP1 AKT1 0 0 298 306 1 2
    TP53INP1 ZMAT3 0 0 335 414 1 1
    TP53INP1 DROSHA 0 0 273 273 1 1
    TP53INP1 MTNR1B 0 0 276 288 1 1
    TP53INP1 R3HDML 0 0 170 169 1 1
    TP53INP1 XIAP 0 0 170 198 1 1
    TP53INP1 VMP1 0 0 245 244 1 2
    TP53INP1 EIF2B2 0 0 0 189 1 1
    TP53INP1 PPP2R4 0 0 73 171 1 1
    TP53INP1 ATL2 0 0 95 485 1 1
    TP53INP1 WSB1 0 0 96 234 1 1
    TP53INP1 ATF6 0 0 137 187 1 2
    TP53INP1 KIAA0226L 0 0 75 151 1 1
    TP53INP1 PLEKHH1 0 0 108 245 1 1
    TP53INP1 BLOC1S4 0 0 142 482 1 1
    TP53INP1 DIDO1 0 0 62 220 1 1
    TP53INP1 BCL2L11 0 0 266 266 1 1
    TP53INP1 KIF11 0 0 113 168 1 1
    TP53INP1 INTS6 0 0 261 311 1 1
    TP53INP1 DAPK1 0 0 66 162 1 2
    TP53INP1 TAF1 0 0 54 150 1 1
    TP53INP1 CDCA3 0 0 74 391 1 1
    TP53INP1 ARL4A 0 0 0 191 1 1
    TP53INP1 JUN 0 0 239 245 1 1
    TP53INP1 CCNA2 0 0 167 177 1 1
    TP53INP1 TEX2 0 0 96 235 1 1
    TP53INP1 SNCA 0 0 170 169 1 2
    TP53INP1 SPATA18 0 0 161 161 1 1
    TP53INP1 TNFSF10 0 0 57 150 1 2
    TP53INP1 CAV1 0 0 125 187 1 1
    TP53INP1 CERS5 0 0 0 153 1 1
    TP53INP1 HSPA1A 0 0 260 311 1 1
    TP53INP1 BIK 0 0 173 187 1 1
    TP53INP1 IGFBP3 0 0 134 188 1 1
    TP53INP1 CAMK1D 0 0 334 334 1 1
    TP53INP1 STYX 0 0 90 287 1 1
    TP53INP1 RUNX3 0 0 201 320 1 1
    TP53INP1 MAST2 0 0 60 201 1 1
    TP53INP1 ITGA10 0 0 61 165 1 1
    TP53INP1 TLE4 0 0 157 156 1 1
    TP53INP1 ABI1 0 0 0 318 1 1
    TP53INP1 DOCK9 0 0 58 219 1 1
    TP53INP1 SP6 0 0 322 350 1 1
    TP53INP1 DLEC1 0 0 0 189 1 1
    TP53INP1 CDC25C 0 0 153 152 1 1
    TP53INP1 PLEKHF2 0 0 97 254 1 1
    TP53INP1 WISP2 0 0 82 173 1 1
    TP53INP1 ZEB1 0 0 233 232 1 1
    TP53INP1 LOXL4 0 0 60 158 1 1
    TP53INP1 SGMS1 0 0 108 201 1 1
    TP53INP1 GABARAPL1 115 0 213 394 1 2
    TP53INP1 CDKN1A 0 0 391 445 1 2
    TP53INP1 EPCAM 0 0 124 540 1 1
    TP53INP1 AR 0 0 124 222 1 1
    TP53INP1 HSPA8 0 0 193 224 1 2
    TP53INP1 SPO11 0 0 294 294 1 1
    TP53INP1 NUDT4 0 0 218 218 1 1
    TP53INP1 PIWIL1 0 0 150 173 1 1
    TP53INP1 KLRK1 0 0 217 217 1 1
    TP53INP1 CASZ1 0 0 212 261 1 1
    TP53INP1 TPM1 0 0 142 175 1 1
    TP53INP1 FAM212B 0 0 261 294 1 1
    TP53INP1 OLFM1 0 0 96 151 1 1
    TP53INP1 HOXB1 0 0 108 261 1 1
    TP53INP1 INS 0 0 236 236 1 1
    TP53INP1 ACTB 0 0 294 299 1 1
    TP53INP1 HOXA5 0 0 263 263 1 1
    TP53INP1 MSMO1 0 0 104 191 1 1
    TP53INP1 STUB1 0 0 171 171 1 2
    TP53INP1 PROM1 0 0 218 266 1 1
    TP53INP1 ARL2BP 0 0 234 234 1 1
    TP53INP1 KEAP1 0 0 167 167 1 2
    TP53INP1 TSPYL2 0 0 61 222 1 1
    TP53INP1 FAR1 0 0 57 202 1 1
    TP53INP1 MICB 0 0 147 186 1 1
    TP53INP1 SQSTM1 312 0 218 451 1 2
    TP53INP1 BNIP3 0 0 147 189 1 2
    TP53INP1 PBX3 0 0 136 159 1 1
    TP53INP1 ZSCAN20 0 0 261 274 1 1
    TP53INP1 HSP90AA1 0 0 305 305 1 2
    TP53INP1 FBXW7 0 0 135 154 1 1
    TP53INP1 HDAC4 0 0 141 235 1 1
    TP53INP1 DOCK10 0 0 0 205 1 1
    TP53INP1 ALX4 0 0 55 202 1 1
    TP53INP1 SP100 0 0 266 266 1 1
    TP53INP1 TP73 0 0 181 197 1 2
    TP53INP1 ALB 0 0 180 179 1 1
    TP53INP1 GADD45GIP1 0 0 126 188 1 1
    TP53INP1 CASP8 0 0 172 190 1 2
    TP53INP1 ZNF33A 0 0 157 156 1 1
    TP53INP1 PIWIL4 0 0 143 154 1 1
    TP53INP1 DUSP9 0 0 322 353 1 1
    TP53INP1 THADA 0 0 225 224 1 1
    TP53INP1 ADCY5 0 0 141 276 1 1
    TP53INP1 RASSF6 0 0 181 265 1 1
    TP53INP1 TARBP2 0 0 91 287 1 1
    TP53INP1 TP53AIP1 0 0 431 431 1 1
    TP53INP1 BIRC3 0 0 158 220 1 1
    TP53INP1 SMAD3 0 0 96 183 1 1
    TP53INP1 CDK6 0 0 245 261 1 1
    TP53INP1 ENSG00000278848 0 0 233 232 1 1
    TP53INP1 CERS2 0 0 108 351 1 1
    TP53INP1 CDH1 0 0 180 179 1 1
    TP53INP1 ZEB2 0 0 204 204 1 1
    TP53INP1 GLB1 0 0 0 190 1 1
    TP53INP1 MAP3K11 0 0 94 233 1 1
    TP53INP1 PPP1CB 0 0 181 237 1 1
    TP53INP1 MAP1LC3C 118 0 0 211 1 2
    TP53INP1 HBZ 0 0 202 245 1 1
    TP53INP1 SESN2 0 0 370 396 1 2
    TP53INP1 NR3C1 0 0 94 196 1 1
    TP53INP1 CISH 0 0 82 178 1 1
    TP53INP1 RIPPLY1 0 0 112 167 1 1
    TP53INP1 DAPK3 0 0 57 313 1 2
    TP53INP1 ZNF79 0 0 205 205 1 1
    TP53INP1 BCL11A 0 0 266 430 1 1
    TP53INP1 CAMTA1 0 0 134 169 1 1
    TP53INP1 SKP2 0 0 170 169 1 1
    TP53INP1 ADIPOQ 0 0 66 165 1 1
    TP53INP1 API5 0 0 74 214 1 1
    TP53INP1 E4F1 0 0 269 269 1 1
    TP53INP1 UPP1 0 0 193 518 1 1
    TP53INP1 C9orf172 0 0 0 250 1 1
    TP53INP1 RAPGEF1 0 0 0 294 1 1
    TP53INP1 MUT 0 0 155 173 1 1
    TP53INP1 FOXP1 0 0 217 234 1 1
    TP53INP1 DUSP12 0 0 171 171 1 1
    TP53INP1 PLK2 0 0 284 284 1 1
    TP53INP1 CYCS 0 0 228 227 1 1
    TP53INP1 GADD45B 0 0 142 235 1 1
    TP53INP1 ZNF592 0 0 112 248 1 1
    TP53INP1 HK1 0 0 438 438 1 1
    TP53INP1 CASP9 0 0 183 183 1 1
    TP53INP1 SESN3 0 0 108 182 1 1
    TP53INP1 TGM7 0 0 0 189 1 1
    TP53INP1 SEC14L1 0 0 76 218 1 1
    TP53INP1 ZNF135 0 0 170 189 1 1
    TP53INP1 CDC6 0 0 125 187 1 1
    TP53INP1 PELI1 0 0 75 285 1 1
    TP53INP1 AGMO 0 0 155 154 1 1
    TP53INP1 ETS1 0 0 151 150 1 1
    TP53INP1 SENP1 0 0 131 193 1 1
    TP53INP1 CDKN1C 0 0 211 230 1 1
    TP53INP1 ATL3 0 0 0 302 1 1
    TP53INP1 DICER1 0 0 281 281 1 1
    TP53INP1 PIK3R1 0 0 84 160 1 1
    TP53INP1 SEPT9 0 0 0 204 1 1
    TP53INP1 HSPA4 0 0 543 543 1 1
    TP53INP1 CCNJL 0 0 151 209 1 1
    TP53INP1 HIF1AN 0 0 62 160 1 1
    TP53INP1 PPARA 0 0 91 193 1 1
    TP53INP1 PDCD4 0 0 405 405 1 1
    TP53INP1 HSPB3 0 0 260 260 1 1
    TP53INP1 XPO5 0 0 210 210 1 1
    TP53INP1 HSP90B1 0 0 150 169 1 1
    TP53INP1 DAB2 0 0 112 186 1 1
    TP53INP1 PARK2 0 0 170 169 1 1
    TP53INP1 NR0B2 0 0 0 168 1 1
    TP53INP1 DCD 0 0 288 288 1 1
    TP53INP1 SLC35D2 0 0 95 234 1 1
    TP53INP1 MYC 0 0 341 341 1 2
    TP53INP1 ATP1B1 0 0 0 173 1 1
    TP53INP1 WFS1 0 0 283 294 1 1
    TP53INP1 PI3 0 0 350 349 1 1
    TP53INP1 PPARGC1A 0 0 150 203 1 1
    TP53INP1 HIST1H2BD 0 0 179 200 1 1
    TP53INP1 TAB2 0 0 89 168 1 1
    TP53INP1 GNAQ 0 0 0 153 1 1
    TP53INP1 PPP1R3C 0 0 135 161 1 1
    TP53INP1 GPX7 0 0 392 392 1 1
    TP53INP1 SOAT2 0 0 60 158 1 1
    TP53INP1 HNRNPUL1 0 0 263 263 1 1
    TP53INP1 LBR 0 0 70 158 1 1
    TP53INP1 TFAP2B 0 0 53 200 1 1
    TP53INP1 NOL3 0 0 271 271 1 1
    TP53INP1 LRIG3 0 0 57 202 1 1
    TP53INP1 TNFRSF12A 0 0 124 155 1 1
    TP53INP1 SMAD4 0 0 207 235 1 1
    TP53INP1 JMY 0 0 262 375 1 1
    TP53INP1 MYCN 0 0 215 215 1 1
    TP53INP1 IER5 0 0 203 203 1 1
    TP53INP1 NDUFS3 0 0 74 217 1 1
    TP53INP1 ZNF697 0 0 186 186 1 1
    TP53INP1 C2CD4A 0 0 260 260 1 1
    TP53INP1 NUPR1 0 0 759 764 1 1
    TP53INP1 CIDEA 0 0 0 252 1 1
    TP53INP1 PPP1R13B 0 0 218 271 1 1
    TP53INP1 NFE2L2 0 0 156 155 1 1
    TP53INP1 CHAC1 0 0 175 231 1 1
    TP53INP1 PHLDA3 0 0 235 305 1 1
    TP53INP1 OASL 0 0 47 220 1 1
    TP53INP1 FKBP7 0 0 277 277 1 1
    TP53INP1 BRCA1 0 0 167 167 1 1
    TP53INP1 BNIP2 0 0 90 227 1 1
    TP53INP1 USP37 0 0 57 229 1 1
    TP53INP1 NR1H2 0 0 0 390 1 1
    TP53INP1 TRIM16 0 0 604 604 1 2
    TP53INP1 TGM2 0 0 115 175 1 1
    TP53INP1 TP53 486 600 713 936 1 2
    TP53INP1 MDM2 0 0 459 472 1 1
    TP53INP1 HTT 0 0 166 192 1 1
    TP53INP1 EGFR 0 0 194 211 1 1
    TP53INP1 CFLAR 0 0 95 157 1 1
    TP53INP1 CDK4 0 0 195 195 1 1
    TP53INP1 FADD 0 0 129 162 1 2
    TP53INP1 HK2 0 0 304 304 1 1
    TP53INP1 TRAF1 0 0 135 184 1 1
    TP53INP1 HAND1 0 0 57 202 1 1
    TP53INP1 RBL1 0 0 95 297 1 1
    TP53INP1 RMI1 0 0 0 173 1 1
    TP53INP1 DDIT3 0 0 265 265 1 2
    TP53INP1 ANP32E 0 0 61 159 1 1
    TP53INP1 ASB6 0 0 58 153 1 1
    TP53INP1 APAF1 0 0 245 263 1 1
    TP53INP1 TP53RK 0 0 142 232 1 1
    TP53INP1 GPR156 0 0 124 469 1 1
    TP53INP1 SETD8 0 0 297 297 1 1
    TP53INP1 PIN1 0 600 48 602 1 1
    TP53INP1 ENC1 0 0 212 212 1 1
    TP53INP1 CLU 0 0 304 304 1 2
    TP53INP1 GCLM 0 0 90 253 1 1
    TP53INP1 SIVA1 0 0 204 278 1 1
    TP53INP1 ITGB8 0 0 166 182 1 1
    TP53INP1 C7orf60 0 0 108 202 1 1
    TP53INP1 CD300C 0 0 439 439 1 1
    TP53INP1 RBMS1 0 0 134 152 1 1
    TP53INP1 STAT3 0 0 261 277 1 2
    TP53INP1 AGO2 0 0 213 214 1 1
    TP53INP1 CSRNP3 0 0 102 495 1 1
    TP53INP1 FITM2 0 0 208 252 1 1
    TP53INP1 NR1H3 0 0 0 390 1 1
    TP53INP1 FBXO22 0 0 150 188 1 1
    TP53INP1 FBXL12 0 0 0 189 1 1
    TP53INP1 HIF1A 0 0 234 234 1 2
    TP53INP1 GCK 0 0 52 151 1 1
    TP53INP1 BAG3 0 0 261 287 1 2
    TP53INP1 PIR 0 0 171 308 1 1
    TP53INP1 KCNQ1 0 0 298 323 1 1
    TP53INP1 NDRG1 0 0 183 201 1 1
    TP53INP1 LATS2 0 0 218 222 1 1
    TP53INP1 LURAP1L 0 0 103 164 1 1
    TP53INP1 EGR1 0 0 169 169 1 1
    TP53INP1 EPHA2 0 0 95 151 1 1
    TP53INP1 CDK2 0 0 175 214 1 1
    TP53INP1 CTNNB1 0 0 204 204 1 1
    TP53INP1 MAP1LC3A 312 0 47 458 1 2
    TP53INP1 HRAS 0 0 234 234 1 1
    TP53INP1 CAPRIN2 0 0 112 249 1 1
    TP53INP1 ORC1 0 0 0 303 1 1
    TP53INP1 OAF 0 0 0 225 1 1
    TP53INP1 SCO2 0 0 156 155 1 1
    TP53INP1 NOTCH1 0 0 167 167 1 1
    TP53INP1 CCNC 0 0 112 265 1 1
    TP53INP1 TP53TG3 0 0 223 223 1 1
    TP53INP1 PIDD1 0 0 213 213 1 1
    TP53INP1 LXN 0 0 107 201 1 1
    TP53INP1 JARID2 0 0 167 188 1 1
    TP53INP1 E2F2 0 0 218 231 1 1
    TP53INP1 C1RL 0 0 75 239 1 1
    TP53INP1 MTOR 0 0 194 194 1 2
    TP53INP1 BZW2 0 0 0 186 1 1
    TP53INP1 IL6 0 0 182 181 1 1
    TP53INP1 ATL1 0 0 0 190 1 1
    TP53INP1 ALDH3B1 0 0 155 154 1 1
    TP53INP1 BCL2L2-PABPN1 0 0 160 159 1 1
    TP53INP1 CREBBP 0 0 136 168 1 1
    TP53INP1 DGCR8 0 0 171 171 1 1
    TP53INP1 CKAP5 0 0 45 305 1 1
    TP53INP1 ESRRA 0 0 0 156 1 1
    TP53INP1 BCL11B 0 0 101 190 1 1
    TP53INP1 KCNJ11 0 0 143 201 1 1
    TP53INP1 RECK 0 0 213 213 1 1
    TP53INP1 TWSG1 0 0 139 174 1 1
    TP53INP1 ZNF761 0 0 321 321 1 1
    TP53INP1 ETNPPL 0 0 74 216 1 1
    TP53INP1 HSPD1 0 0 166 171 1 1
    TP53INP1 PERP 0 0 232 253 1 1
    TP53INP1 SNED1 0 0 55 160 1 1
    TP53INP1 RPA3 0 0 0 254 1 1
    TP53INP1 GRPEL1 0 0 235 235 1 1
    TP53INP1 FTO 0 0 247 248 1 1
    TP53INP1 ANXA5 0 0 242 241 1 1
    TP53INP1 MAP1LC3B2 0 0 0 161 1 2
    TP53INP1 CCNB1 0 0 144 150 1 1
    TP53INP1 VASH2 0 0 43 190 1 1
    TP53INP1 BCAS4 0 0 0 188 1 1
    TP53INP1 PLK1 0 0 166 165 1 1
    TP53INP1 PHLPP1 0 0 163 177 1 1
    TP53INP1 NABP1 0 0 134 237 1 1
    TP53INP1 IGF2BP2 0 0 258 273 1 1
    TP53INP1 BCL2L1 0 0 266 266 1 2
    TP53INP1 UHRF1 0 0 66 160 1 1
    TP53INP1 GAPDH 0 0 283 282 1 2
    TP53INP1 TRIAP1 0 0 202 256 1 1
    TP53INP1 SH2B3 0 0 167 296 1 1
    TP53INP1 FAM107A 0 0 166 165 1 1
    TP53INP1 SMAD2 0 0 152 167 1 1
    TP53INP1 ZNF189 0 0 108 172 1 1
    TP53INP1 PELI2 0 0 0 169 1 1
    TP53INP1 ABL1 0 0 169 169 1 1
    TP53INP1 TUSC1 0 0 167 197 1 1
    TP53INP1 GABARAPL2 412 0 517 751 1 2
    TP53INP1 TCF7L2 0 0 294 294 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0016209 Molecular Function antioxidant activity enables ISS
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0006915 Biological Process apoptotic process involved_in IEA
    GO:0048102 Biological Process autophagic cell death involved_in IMP
    GO:0000045 Biological Process autophagosome assembly involved_in IBA
    GO:0098869 Biological Process cellular oxidant detoxification involved_in IEA
    GO:0034644 Biological Process cellular response to UV involved_in IEA
    GO:0071361 Biological Process cellular response to ethanol involved_in IEA
    GO:0071447 Biological Process cellular response to hydroperoxide involved_in IEA
    GO:0072703 Biological Process cellular response to methyl methanesulfonate involved_in IEA
    GO:0030336 Biological Process negative regulation of cell migration involved_in ISS
    GO:0008285 Biological Process negative regulation of cell population proliferation involved_in ISS
    GO:0048147 Biological Process negative regulation of fibroblast proliferation involved_in IEA
    GO:0010629 Biological Process negative regulation of gene expression involved_in IEA
    GO:1904761 Biological Process negative regulation of myofibroblast differentiation involved_in IEA
    GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in IBA
    GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in IDA
    GO:0043065 Biological Process positive regulation of apoptotic process involved_in IEA
    GO:0010508 Biological Process positive regulation of autophagy involved_in IMP
    GO:0010628 Biological Process positive regulation of gene expression involved_in IEA
    GO:0051726 Biological Process regulation of cell cycle involved_in TAS
    GO:0009408 Biological Process response to heat involved_in IEA
    GO:0016605 Cellular Component PML body located_in IEA
    GO:0005776 Cellular Component autophagosome is_active_in IBA
    GO:0005776 Cellular Component autophagosome located_in IDA
    GO:0031410 Cellular Component cytoplasmic vesicle located_in IEA
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005654 Cellular Component nucleoplasm located_in TAS
    GO:0005634 Cellular Component nucleus is_active_in IBA
    GO:0005634 Cellular Component nucleus located_in IDA
    Pathways
    Name DB ID
    Generic Transcription Pathway Reactome R-HSA-212436
    Transcriptional Regulation by TP53 Reactome R-HSA-3700989
    Regulation of TP53 Activity Reactome R-HSA-5633007
    TP53 Regulates Transcription of Cell Death Genes Reactome R-HSA-5633008
    TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Reactome R-HSA-6803204
    Regulation of TP53 Activity through Phosphorylation Reactome R-HSA-6804756
    RNA Polymerase II Transcription Reactome R-HSA-73857
    Gene expression (Transcription) Reactome R-HSA-74160
    p53 transcriptional gene network (WP4963) WikiPathways WP4963_r122690
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_033285 4 mRNA transcript variant 1 NC_000008 Reference
    NM_001135733 2 mRNA transcript variant 2 NC_000008 Reference
    XM_011517386 3 mRNA transcript variant X1 NC_000008 Reference