SPHK1

sphingosine kinase 1
General Information
Name sphingosine kinase 1
Alias
  • sphingosine kinase 1
  • SK 1
  • SPK 1
  • acetyltransferase SPHK1
Synonyms SPHK
Gene_family None
organism Homo sapiens
entrez_id 8877
location 17q25.1
transcript_count 5
exon_count 7
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
      Stringdb Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N- dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol
      nextProt Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    SPHK1 BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
    SPHK1 BioGRID CTU2 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID TUBB8 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID ANKRD40 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID CTU1 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID QTRT2 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID AFG2B GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID KLHL8 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID TOMM22 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID MAP1S GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID SMG8 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID WRAP53 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID CCZ1 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID DCXR GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID RDH11 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID LEMD3 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID PPIP5K1 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID BAG5 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID TTC1 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID SMARCD1 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID CYLD GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID ALDH3B1 GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    SPHK1 BioGRID IL12RB1 GeneID BioGRID Positive Genetic
    SPHK1 BioGRID IL10 GeneID BioGRID Positive Genetic
    SPHK1 BioGRID KLHL5 GeneID BioGRID Affinity Capture-Western
    SPHK1 BioGRID SRC GeneID BioGRID Negative Genetic
    SPHK1 BioGRID PRKCD GeneID BioGRID Negative Genetic
    SPHK1 BioGRID PIK3CG GeneID BioGRID Negative Genetic
    SPHK1 BioGRID AANAT GeneID BioGRID Positive Genetic
    SPHK1 BioGRID MAP4K1 GeneID BioGRID Negative Genetic
    SPHK1 BioGRID GMPS GeneID BioGRID Negative Genetic
    SPHK1 BioGRID BECN1 GeneID BioGRID Affinity Capture-Western
    SPHK1 BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    SPHK1 BioGRID DHPS GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID PPM1G GeneID BioGRID Affinity Capture-MS
    SPHK1 BioGRID BIRC3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    SPHK1 BioGRID MBTPS1 GeneID BioGRID Biochemical Activity
    SPHK1 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western
    SPHK1 BioGRID RARG GeneID BioGRID Two-hybrid
    SPHK1 BioGRID EP300 GeneID BioGRID Biochemical Activity
    SPHK1 Protein SPHKAP GeneID HPRD None
    SPHK1 Protein RPS6KC1 GeneID HPRD None
    SPHK1 Protein CTNND2 GeneID HPRD None
    SPHK1 Protein TRAF6 GeneID HPRD None
    SPHK1 Protein TRAF2 GeneID HPRD None
    SPHK1 Protein LYN GeneID HPRD None
    SPHK1 Protein FYN GeneID HPRD None
    SPHK1 Protein CTSB GeneID HPRD None
    SPHK1 BioGRID RPS6KC1 GeneID BioGRID Affinity Capture-Western
    StringDB
    A B experiments database textmining combined score hadb nhadb
    SPHK1 PTPLA 0 0 70 279 1 1
    SPHK1 HS3ST1 0 0 84 334 1 1
    SPHK1 ENSG00000273136 0 0 231 230 1 1
    SPHK1 RELA 0 0 150 171 1 1
    SPHK1 EVPL 0 0 53 311 1 1
    SPHK1 GAPDH 0 0 427 469 1 2
    SPHK1 LPAR5 0 0 166 206 1 1
    SPHK1 CX3CL1 0 0 152 170 1 1
    SPHK1 MAP2K7 0 0 161 161 1 1
    SPHK1 ABL1 0 0 211 223 1 1
    SPHK1 TPCN2 0 0 49 150 1 1
    SPHK1 PFKFB3 0 0 113 220 1 1
    SPHK1 CREB1 0 0 215 215 1 1
    SPHK1 CTNND1 0 0 107 156 1 1
    SPHK1 CRLS1 0 0 0 191 1 1
    SPHK1 ZDHHC17 0 0 0 286 1 1
    SPHK1 C5AR1 0 0 193 199 1 1
    SPHK1 HSF1 0 0 0 158 1 1
    SPHK1 IQGAP1 0 0 155 154 1 1
    SPHK1 PSAP 0 0 84 166 1 1
    SPHK1 SC5D 0 0 0 219 1 1
    SPHK1 SPNS1 0 0 0 388 1 2
    SPHK1 MMP1 0 0 101 192 1 1
    SPHK1 CYR61 0 0 108 157 1 1
    SPHK1 CXCR4 0 0 243 242 1 2
    SPHK1 MOSPD1 0 0 0 152 1 1
    SPHK1 CD163 0 0 193 193 1 1
    SPHK1 MTOR 0 0 273 303 1 2
    SPHK1 DCXR 680 0 0 680 1 1
    SPHK1 EPHX2 0 0 134 264 1 1
    SPHK1 LPAR3 0 0 283 300 1 1
    SPHK1 PIK3C3 0 0 70 160 1 2
    SPHK1 HSFX1 0 0 0 158 1 1
    SPHK1 FN3K 0 0 73 234 1 1
    SPHK1 IL17D 0 0 47 155 1 1
    SPHK1 OCLN 0 0 163 163 1 1
    SPHK1 PLEK 0 0 180 186 1 1
    SPHK1 NPHS1 0 0 85 223 1 1
    SPHK1 STAT1 0 0 167 167 1 1
    SPHK1 ELAVL3 0 0 0 394 1 1
    SPHK1 PDZK1 270 0 0 270 1 1
    SPHK1 SMPD3 0 0 519 540 1 1
    SPHK1 UGT8 0 0 268 297 1 1
    SPHK1 CXCL8 0 0 324 373 1 1
    SPHK1 SGSM2 0 0 63 154 1 1
    SPHK1 CD151 0 0 109 161 1 1
    SPHK1 DDX28 0 0 0 192 1 1
    SPHK1 S1PR3 0 0 843 858 1 1
    SPHK1 APP 0 0 183 183 1 1
    SPHK1 EGR1 0 0 113 162 1 1
    SPHK1 CTNNB1 0 0 288 377 1 1
    SPHK1 HRAS 0 900 223 922 1 1
    SPHK1 N4BP2L1 0 0 0 201 1 1
    SPHK1 AMIGO2 0 0 134 165 1 1
    SPHK1 C3AR1 0 0 95 165 1 1
    SPHK1 MTSS1 0 0 142 165 1 1
    SPHK1 MREG 0 0 134 188 1 1
    SPHK1 CDH2 0 0 258 258 1 1
    SPHK1 PTX3 0 0 96 167 1 1
    SPHK1 APAF1 0 0 90 157 1 1
    SPHK1 PLEKHA8 0 0 261 265 1 1
    SPHK1 SEMA3C 0 0 57 177 1 1
    SPHK1 JAK2 0 0 200 212 1 1
    SPHK1 PUF60 0 0 0 217 1 1
    SPHK1 CLU 0 0 138 171 1 2
    SPHK1 HUWE1 270 0 0 278 1 1
    SPHK1 FAM171A1 0 0 96 187 1 1
    SPHK1 CDIP1 0 0 102 542 1 1
    SPHK1 SPTLC1 0 0 470 715 1 1
    SPHK1 ITGA5 0 0 125 216 1 1
    SPHK1 HBEGF 0 0 166 191 1 1
    SPHK1 DEGS2 0 900 401 958 1 1
    SPHK1 GCAT 0 0 0 154 1 1
    SPHK1 HMGCS1 0 0 52 277 1 1
    SPHK1 TGM2 0 0 120 163 1 1
    SPHK1 PRPSAP1 0 0 93 433 1 1
    SPHK1 LRIG1 0 0 134 176 1 1
    SPHK1 TP53 0 0 390 390 1 2
    SPHK1 LCN2 0 0 172 171 1 1
    SPHK1 EGFR 0 0 369 369 1 1
    SPHK1 OSBPL5 0 0 0 176 1 1
    SPHK1 FPGS 0 0 0 177 1 1
    SPHK1 ADAMTS1 0 0 93 183 1 1
    SPHK1 IRAK1 0 0 122 186 1 1
    SPHK1 P2RX4 0 0 74 193 1 1
    SPHK1 PSMA8 270 0 0 315 1 1
    SPHK1 C2orf66 0 0 166 165 1 1
    SPHK1 HDAC2 0 0 335 408 1 1
    SPHK1 KPNA3 0 0 0 208 1 1
    SPHK1 ADAT2 0 0 0 174 1 1
    SPHK1 INHBA 0 0 123 155 1 1
    SPHK1 TMEM45A 0 0 96 187 1 1
    SPHK1 MFSD2B 0 0 468 562 1 1
    SPHK1 TNFRSF12A 0 0 82 188 1 1
    SPHK1 FLNA 0 0 807 819 1 1
    SPHK1 C19orf43 0 0 135 359 1 1
    SPHK1 B3GALT4 0 0 94 169 1 1
    SPHK1 A4GALT 0 0 88 155 1 1
    SPHK1 SMPDL3A 0 0 117 297 1 1
    SPHK1 GTF3C3 0 0 0 158 1 1
    SPHK1 AQP1 0 0 74 216 1 1
    SPHK1 AREG 0 0 174 248 1 1
    SPHK1 CCL21 0 0 163 163 1 1
    SPHK1 PDGFB 0 900 181 916 1 1
    SPHK1 MXRA7 0 0 82 484 1 1
    SPHK1 LAMA5 0 0 136 158 1 1
    SPHK1 MAD2L1 270 0 0 270 1 1
    SPHK1 UCK2 0 0 67 184 1 1
    SPHK1 IL15 0 0 113 168 1 1
    SPHK1 FA2H 0 0 123 570 1 1
    SPHK1 IL36G 0 0 90 173 1 1
    SPHK1 GNAQ 0 0 230 257 1 1
    SPHK1 PTPLB 0 0 0 256 1 1
    SPHK1 ACP5 0 0 89 157 1 1
    SPHK1 VAPA 0 0 0 164 1 1
    SPHK1 PPAP2B 0 900 466 954 1 1
    SPHK1 CYCS 0 0 338 350 1 1
    SPHK1 DUSP12 0 0 118 173 1 1
    SPHK1 ELOVL1 0 0 134 209 1 1
    SPHK1 TRAF6 270 0 450 587 1 2
    SPHK1 ENPP7 0 0 405 424 1 1
    SPHK1 PLAU 0 0 139 190 1 1
    SPHK1 SH3GLB1 62 0 453 465 1 2
    SPHK1 BMP2 0 0 124 184 1 1
    SPHK1 EGF 0 0 419 418 1 1
    SPHK1 LIPJ 0 0 0 161 1 1
    SPHK1 LPIN3 0 0 158 249 1 1
    SPHK1 CRHR1 0 0 251 251 1 1
    SPHK1 PROCR 0 0 321 342 1 1
    SPHK1 PLAUR 0 0 151 237 1 1
    SPHK1 ZDHHC13 0 0 0 286 1 1
    SPHK1 PITPNC1 0 0 0 150 1 1
    SPHK1 PPARA 0 0 216 216 1 1
    SPHK1 TEK 0 0 172 171 1 1
    SPHK1 KPNA7 0 0 0 275 1 1
    SPHK1 CCR2 0 0 195 195 1 2
    SPHK1 DIABLO 0 0 218 218 1 1
    SPHK1 TUFM 270 0 0 270 1 1
    SPHK1 THUMPD1 0 0 0 370 1 1
    SPHK1 MAPK8 0 0 202 202 1 2
    SPHK1 PTK2 0 0 227 226 1 1
    SPHK1 PLD1 0 800 258 864 1 1
    SPHK1 VPS33A 0 0 0 181 1 1
    SPHK1 CTH 0 0 65 209 1 1
    SPHK1 RAB32 0 0 0 196 1 2
    SPHK1 PRKCZ 0 900 234 921 1 1
    SPHK1 CDH1 0 0 294 294 1 1
    SPHK1 PDGFRA 0 900 112 909 1 1
    SPHK1 SMARCE1 0 0 0 165 1 1
    SPHK1 EREG 0 0 441 441 1 1
    SPHK1 AANAT 105 0 46 510 1 1
    SPHK1 H3F3B 0 0 0 199 1 1
    SPHK1 TRADD 0 0 357 380 1 1
    SPHK1 ROCK2 270 0 157 394 1 1
    SPHK1 KLHL6 0 0 92 175 1 1
    SPHK1 PSMB2 270 0 0 320 1 1
    SPHK1 ALB 0 0 394 431 1 1
    SPHK1 CDC23 0 0 0 259 1 1
    SPHK1 CD68 0 0 166 210 1 1
    SPHK1 CCL2 0 0 341 368 1 2
    SPHK1 SNAI2 0 0 194 296 1 1
    SPHK1 ELAVL1 0 0 109 171 1 1
    SPHK1 PITPNM1 0 0 0 179 1 1
    SPHK1 PKLR 0 0 95 176 1 1
    SPHK1 DDC 0 0 0 174 1 1
    SPHK1 IL4 0 0 262 262 1 1
    SPHK1 EP300 487 0 162 572 1 1
    SPHK1 ADIPOR1 0 0 135 188 1 1
    SPHK1 PDGFRB 0 900 211 917 1 1
    SPHK1 ROCK1 0 0 267 291 1 1
    SPHK1 CACNG7 0 0 70 165 1 1
    SPHK1 RABGAP1L 0 0 0 183 1 1
    SPHK1 BIRC3 270 0 610 703 1 1
    SPHK1 SMAD3 0 0 255 254 1 1
    SPHK1 AP3B2 0 0 0 250 1 1
    SPHK1 SELP 0 0 181 181 1 1
    SPHK1 MSMO1 0 0 42 220 1 1
    SPHK1 FGF1 0 0 244 244 1 1
    SPHK1 EPRS 0 0 119 294 1 1
    SPHK1 SELL 0 0 263 263 1 1
    SPHK1 MMP9 0 0 358 376 1 1
    SPHK1 MAPK3 0 800 563 911 1 2
    SPHK1 SQSTM1 270 0 134 360 1 2
    SPHK1 PCK2 270 0 0 270 1 1
    SPHK1 HSP90AA1 0 0 125 171 1 2
    SPHK1 DPP6 0 0 147 156 1 1
    SPHK1 DHPS 301 0 0 301 1 1
    SPHK1 TEN1 0 0 0 336 1 1
    SPHK1 E2F7 0 0 142 219 1 1
    SPHK1 SET 0 0 245 266 1 1
    SPHK1 SYT1 0 0 687 700 1 1
    SPHK1 RANGAP1 0 0 0 248 1 1
    SPHK1 UGCG 0 0 614 621 1 1
    SPHK1 KPNA5 0 0 0 201 1 1
    SPHK1 ITGAV 0 900 71 903 1 1
    SPHK1 RAB35 270 0 42 292 1 1
    SPHK1 SPOCD1 0 0 97 153 1 1
    SPHK1 SOST 0 0 137 155 1 1
    SPHK1 PTPRC 0 0 202 214 1 1
    SPHK1 SGMS1 0 0 451 507 1 1
    SPHK1 RHBDF2 0 0 141 666 1 1
    SPHK1 ICAM1 0 0 293 332 1 1
    SPHK1 CDKN1A 0 0 174 225 1 2
    SPHK1 SFTPB 0 0 55 156 1 1
    SPHK1 SPP1 0 0 136 169 1 1
    SPHK1 AR 0 0 171 171 1 1
    SPHK1 TIMP1 0 0 234 287 1 1
    SPHK1 BMP6 0 0 207 207 1 1
    SPHK1 KIAA0020 0 0 0 150 1 1
    SPHK1 JAG1 0 0 162 162 1 1
    SPHK1 SERPIND1 0 0 0 213 1 1
    SPHK1 GRB2 270 0 129 395 1 1
    SPHK1 H3F3C 0 0 0 199 1 1
    SPHK1 P2RX5 0 0 45 192 1 1
    SPHK1 FYN 270 0 274 468 1 1
    SPHK1 NPRL3 0 0 74 346 1 1
    SPHK1 SP6 270 0 74 329 1 1
    SPHK1 SHISA9 0 0 0 203 1 1
    SPHK1 SOD1 0 0 82 167 1 1
    SPHK1 LTA 0 0 0 302 1 1
    SPHK1 KPNA2 0 0 0 275 1 1
    SPHK1 TBL1X 0 0 147 162 1 1
    SPHK1 S1PR4 0 0 731 734 1 1
    SPHK1 CDH17 0 0 152 151 1 1
    SPHK1 SLC28A2 0 0 74 201 1 1
    SPHK1 JUN 0 0 360 404 1 1
    SPHK1 ENOX2 0 0 154 153 1 1
    SPHK1 DNTT 0 0 207 218 1 1
    SPHK1 CRTC3 0 0 178 178 1 1
    SPHK1 UTP6 0 0 0 202 1 1
    SPHK1 SPTLC3 0 0 407 616 1 1
    SPHK1 STXBP5 0 0 0 156 1 1
    SPHK1 DGKQ 0 0 218 264 1 1
    SPHK1 PIK3CG 105 0 113 194 1 1
    SPHK1 COL18A1 0 0 173 252 1 1
    SPHK1 AIF1 0 0 155 154 1 1
    SPHK1 SIK2 0 0 137 185 1 1
    SPHK1 FAS 0 0 155 160 1 2
    SPHK1 VCAM1 0 0 289 288 1 1
    SPHK1 MAP3K15 0 0 0 195 1 1
    SPHK1 MBTPS1 270 0 317 590 1 1
    SPHK1 HIST1H4C 270 0 66 301 1 1
    SPHK1 RASD2 0 0 0 222 1 1
    SPHK1 DDX10 0 0 0 179 1 1
    SPHK1 WBP11 0 0 0 302 1 1
    SPHK1 ST8SIA4 0 0 46 305 1 1
    SPHK1 CSF2 0 0 167 191 1 1
    SPHK1 NOX4 0 0 135 174 1 1
    SPHK1 STEAP1B 0 0 180 179 1 1
    SPHK1 TMEM74 0 0 141 163 1 2
    SPHK1 CYLD 450 0 270 581 1 1
    SPHK1 CERS4 0 900 520 964 1 1
    SPHK1 GPT 0 0 134 152 1 1
    SPHK1 ST6GALNAC2 0 0 57 206 1 1
    SPHK1 GJA1 0 0 181 181 1 1
    SPHK1 PINK1 0 0 425 429 1 2
    SPHK1 NGF 0 0 265 288 1 1
    SPHK1 CD34 0 0 218 218 1 1
    SPHK1 GPLD1 0 0 509 509 1 1
    SPHK1 SQRDL 0 0 0 158 1 1
    SPHK1 AIFM1 0 0 0 209 1 1
    SPHK1 FOXQ1 0 0 181 242 1 1
    SPHK1 TGFBI 0 0 122 293 1 1
    SPHK1 CRTAP 0 0 58 399 1 1
    SPHK1 S100A3 0 0 0 184 1 1
    SPHK1 CDC42 0 0 203 203 1 1
    SPHK1 N4BP2L2 0 0 0 201 1 1
    SPHK1 IGFALS 0 0 0 302 1 1
    SPHK1 CCT3 0 600 0 617 1 1
    SPHK1 TNFSF11 0 0 244 253 1 1
    SPHK1 RHBDF1 0 0 74 409 1 1
    SPHK1 APOE 0 0 209 209 1 1
    SPHK1 ALYREF 0 0 0 206 1 1
    SPHK1 TAF4 270 0 0 270 1 1
    SPHK1 LPAR1 0 0 370 370 1 1
    SPHK1 CDKN3 0 0 210 210 1 1
    SPHK1 BIRC6 0 0 0 248 1 1
    SPHK1 RSAD2 0 0 95 163 1 1
    SPHK1 RAC2 0 0 134 166 1 1
    SPHK1 STXBP2 0 0 0 192 1 1
    SPHK1 KDR 0 0 233 232 1 2
    SPHK1 ADIPOR2 0 0 123 176 1 1
    SPHK1 RIPK3 0 0 387 396 1 1
    SPHK1 ENSG00000259316 0 0 89 155 1 1
    SPHK1 PRKCD 105 900 337 935 1 2
    SPHK1 MAP3K6 0 0 0 200 1 1
    SPHK1 PITPNB 0 0 0 150 1 1
    SPHK1 SBF2 0 0 0 151 1 1
    SPHK1 ISX 0 0 0 613 1 1
    SPHK1 GATB 0 0 0 175 1 1
    SPHK1 TGFB1 0 0 171 269 1 1
    SPHK1 MDK 0 0 120 175 1 1
    SPHK1 PITPNM2 0 0 0 179 1 1
    SPHK1 PTPLAD2 0 0 0 188 1 1
    SPHK1 GBA 0 0 280 297 1 1
    SPHK1 MYO1B 270 0 0 291 1 1
    SPHK1 PECAM1 0 900 701 968 1 1
    SPHK1 AGPAT3 0 0 47 215 1 1
    SPHK1 S100A10 0 0 148 183 1 1
    SPHK1 NPHS2 0 0 90 242 1 1
    SPHK1 RETNLB 0 0 241 240 1 1
    SPHK1 LIPA 0 0 54 173 1 1
    SPHK1 L3MBTL2 0 0 50 308 1 1
    SPHK1 SPNS3 0 0 112 267 1 1
    SPHK1 PIK3C2B 0 0 116 167 1 1
    SPHK1 RANBP3 0 0 132 369 1 1
    SPHK1 CCND1 0 0 283 309 1 1
    SPHK1 ANAPC7 0 0 0 199 1 1
    SPHK1 SRPR 0 0 0 167 1 1
    SPHK1 NOS3 0 0 391 404 1 1
    SPHK1 ANXA2 0 0 139 181 1 1
    SPHK1 SPTLC2 0 0 456 647 1 1
    SPHK1 FGF2 0 0 293 293 1 1
    SPHK1 SFRP4 0 0 246 246 1 1
    SPHK1 TNFSF14 0 0 171 470 1 1
    SPHK1 ABCC6 0 0 0 188 1 1
    SPHK1 SEC23IP 0 0 0 189 1 1
    SPHK1 SPTSSB 0 0 205 205 1 1
    SPHK1 MAPK1 0 800 90 814 1 2
    SPHK1 SHROOM1 0 0 82 176 1 1
    SPHK1 IGF1 0 0 294 294 1 1
    SPHK1 CCT2 0 600 0 616 1 1
    SPHK1 EPHB4 0 0 179 242 1 1
    SPHK1 ARPC3 270 0 0 306 1 1
    SPHK1 PKM 0 0 108 188 1 1
    SPHK1 RTN4IP1 0 0 0 307 1 1
    SPHK1 ITPA 0 0 0 163 1 1
    SPHK1 CD44 0 0 202 231 1 1
    SPHK1 BDNF 0 0 138 157 1 2
    SPHK1 DKK3 0 0 46 150 1 1
    SPHK1 LUC7L3 0 0 0 193 1 1
    SPHK1 MYBBP1A 0 0 180 180 1 1
    SPHK1 CASP2 0 0 166 165 1 1
    SPHK1 STAG1 0 0 297 297 1 1
    SPHK1 TANK 0 0 388 388 1 1
    SPHK1 XDH 0 0 53 204 1 1
    SPHK1 FAXDC2 0 0 0 219 1 1
    SPHK1 SEMA4D 0 0 114 154 1 1
    SPHK1 GPR37L1 0 0 57 152 1 1
    SPHK1 SMPD2 0 0 601 765 1 1
    SPHK1 MMP7 0 0 145 178 1 1
    SPHK1 CD209 0 0 96 152 1 1
    SPHK1 CTSK 0 0 204 277 1 1
    SPHK1 LYN 213 900 931 994 1 1
    SPHK1 LIPT1 0 0 0 164 1 1
    SPHK1 HMGB1 0 0 142 173 1 2
    SPHK1 MAP3K5 0 0 112 261 1 1
    SPHK1 PPAP2A 0 0 320 382 1 1
    SPHK1 BACE1 0 0 276 290 1 1
    SPHK1 DGKA 0 0 641 662 1 1
    SPHK1 ITGAM 0 0 224 225 1 1
    SPHK1 SIRT1 0 0 232 231 1 2
    SPHK1 ASAH2B 0 0 74 334 1 1
    SPHK1 MCL1 0 0 294 294 1 2
    SPHK1 CTSB 463 0 320 633 1 2
    SPHK1 MAPK8IP3 0 0 96 158 1 1
    SPHK1 ACOX1 0 0 56 299 1 1
    SPHK1 DPM1 270 0 0 270 1 1
    SPHK1 SPAG6 0 0 0 158 1 1
    SPHK1 GBE1 0 0 45 178 1 1
    SPHK1 ITGB3 0 900 108 911 1 1
    SPHK1 ATG5 0 0 184 240 1 2
    SPHK1 MT-ND1 0 0 0 219 1 1
    SPHK1 ADAM17 0 0 126 165 1 1
    SPHK1 MGLL 0 0 112 206 1 1
    SPHK1 S100A4 0 0 134 183 1 1
    SPHK1 CTHRC1 0 0 204 254 1 1
    SPHK1 TGFBR1 0 0 135 171 1 1
    SPHK1 GALC 0 0 242 287 1 1
    SPHK1 AKT3 0 0 113 154 1 1
    SPHK1 OSBPL9 0 0 0 183 1 1
    SPHK1 CCR7 0 0 181 191 1 1
    SPHK1 OSBPL8 0 0 0 151 1 1
    SPHK1 SOD3 0 0 74 159 1 1
    SPHK1 CERS3 0 900 459 956 1 1
    SPHK1 G6PD 0 0 131 220 1 1
    SPHK1 LCLAT1 0 0 82 260 1 1
    SPHK1 SHC1 0 0 95 155 1 1
    SPHK1 THBD 0 0 113 172 1 1
    SPHK1 ATM 0 0 113 273 1 1
    SPHK1 GPR132 0 0 134 171 1 1
    SPHK1 SERPINC1 0 0 82 247 1 1
    SPHK1 AIF1L 270 0 61 285 1 1
    SPHK1 MUM1L1 0 0 96 152 1 1
    SPHK1 S1PR5 0 0 793 793 1 1
    SPHK1 CYGB 0 0 103 665 1 1
    SPHK1 CTSD 0 0 157 208 1 2
    SPHK1 CXCL2 0 0 145 176 1 1
    SPHK1 ITGB4 0 0 141 159 1 1
    SPHK1 COL1A1 0 0 150 178 1 1
    SPHK1 EFNB2 0 0 194 212 1 1
    SPHK1 CCL20 0 0 124 155 1 1
    SPHK1 ACTG1 270 0 135 341 1 1
    SPHK1 SELE 0 0 193 193 1 1
    SPHK1 KDELC2 0 0 74 167 1 1
    SPHK1 FCER1G 0 900 0 900 1 1
    SPHK1 EDIL3 0 0 46 194 1 1
    SPHK1 PI4KB 0 0 72 163 1 1
    SPHK1 PTEN 0 0 288 289 1 2
    SPHK1 SMPD4 0 0 422 434 1 1
    SPHK1 VEGFA 0 0 469 469 1 1
    SPHK1 SLC10A6 0 0 183 195 1 1
    SPHK1 SREBF1 0 0 155 176 1 2
    SPHK1 GPD2 0 0 0 150 1 1
    SPHK1 MGEA5 0 0 181 181 1 1
    SPHK1 TIMP3 0 0 155 154 1 1
    SPHK1 MAPK14 0 0 134 239 1 1
    SPHK1 FAM49A 0 0 90 162 1 1
    SPHK1 LEP 0 0 158 157 1 1
    SPHK1 SYK 0 900 157 913 1 1
    SPHK1 S1PR1 0 0 822 916 1 1
    SPHK1 GBA2 0 0 195 236 1 1
    SPHK1 NFKBIA 0 0 396 410 1 1
    SPHK1 RNF157 0 0 0 163 1 1
    SPHK1 ORMDL2 0 0 65 230 1 1
    SPHK1 ATG12 0 0 123 172 1 2
    SPHK1 ALOX5 0 0 214 214 1 1
    SPHK1 CXCL5 0 0 141 194 1 1
    SPHK1 ARPC5L 270 0 0 270 1 1
    SPHK1 PITPNM3 0 0 0 179 1 1
    SPHK1 RPS6KC1 270 0 810 855 1 1
    SPHK1 MMP14 0 0 155 240 1 1
    SPHK1 KLF14 0 0 128 168 1 1
    SPHK1 CXCL1 0 0 205 252 1 1
    SPHK1 KIAA1524 0 0 131 175 1 1
    SPHK1 EEF1A1 270 0 111 328 1 1
    SPHK1 CCL11 0 0 150 164 1 1
    SPHK1 PSMB9 0 0 0 175 1 1
    SPHK1 CDC27 0 0 0 201 1 1
    SPHK1 FIGF 0 0 140 159 1 1
    SPHK1 TSPO 0 0 0 181 1 1
    SPHK1 HDAC1 0 0 403 469 1 2
    SPHK1 CSF1 0 0 140 171 1 1
    SPHK1 LIPK 0 0 0 161 1 1
    SPHK1 ZDHHC6 0 0 0 167 1 1
    SPHK1 PHB2 0 0 369 459 1 1
    SPHK1 CRLF3 0 0 72 201 1 1
    SPHK1 ARMCX3 270 0 0 270 1 1
    SPHK1 KLF2 0 0 171 184 1 1
    SPHK1 CHUK 0 0 140 153 1 1
    SPHK1 LIPT2 0 0 0 175 1 1
    SPHK1 NRAS 0 900 125 909 1 1
    SPHK1 LAD1 270 0 0 270 1 1
    SPHK1 FOXO1 0 0 170 169 1 2
    SPHK1 ADRBK1 0 0 122 186 1 1
    SPHK1 ENSG00000250424 0 0 0 206 1 1
    SPHK1 AKAP11 0 0 537 537 1 1
    SPHK1 FOS 0 0 260 260 1 1
    SPHK1 TIFA 0 0 414 414 1 1
    SPHK1 FCER1A 0 900 360 933 1 1
    SPHK1 PISD 0 0 56 208 1 1
    SPHK1 LMO2 0 0 108 202 1 1
    SPHK1 ANGPTL4 0 0 164 196 1 1
    SPHK1 OSBPL11 0 0 0 167 1 1
    SPHK1 CNP 0 0 0 201 1 1
    SPHK1 RABGAP1 0 0 0 183 1 1
    SPHK1 CD86 0 0 200 200 1 1
    SPHK1 NAAA 0 0 86 181 1 1
    SPHK1 PGF 0 0 150 169 1 1
    SPHK1 ORMDL1 0 0 183 327 1 1
    SPHK1 OTC 0 0 70 166 1 1
    SPHK1 STXBP1 0 0 0 192 1 1
    SPHK1 SGPP1 0 900 686 979 1 1
    SPHK1 MET 0 0 166 202 1 1
    SPHK1 PHB 0 0 114 155 1 1
    SPHK1 TRAF3 0 0 389 388 1 2
    SPHK1 PMAIP1 0 0 113 199 1 1
    SPHK1 CERS6 0 900 611 971 1 1
    SPHK1 TLR2 0 0 209 209 1 1
    SPHK1 PIM3 0 0 108 157 1 1
    SPHK1 CLEC7A 0 0 108 170 1 1
    SPHK1 PPAP2C 0 900 241 928 1 1
    SPHK1 TOM1 0 0 0 361 1 1
    SPHK1 MYO1D 270 0 0 300 1 1
    SPHK1 BCL2L1 0 0 340 340 1 2
    SPHK1 ANAPC5 0 0 0 160 1 1
    SPHK1 APOM 0 0 517 565 1 1
    SPHK1 LIPM 0 0 0 161 1 1
    SPHK1 C1orf110 0 0 155 154 1 1
    SPHK1 SMAD2 0 0 193 193 1 1
    SPHK1 TLR4 0 0 290 290 1 1
    SPHK1 NOS2 0 0 108 160 1 1
    SPHK1 AGPAT5 0 0 57 223 1 1
    SPHK1 APOA1 0 0 145 163 1 1
    SPHK1 SPHKAP 270 900 694 975 1 1
    SPHK1 VSTM4 0 0 93 184 1 1
    SPHK1 CCL5 0 0 278 278 1 1
    SPHK1 SLC25A10 0 0 0 171 1 1
    SPHK1 IFNG 0 0 180 197 1 2
    SPHK1 TRPC1 0 0 134 228 1 1
    SPHK1 AP3B1 0 0 46 253 1 1
    SPHK1 GALK1 270 0 0 294 1 1
    SPHK1 ANXA5 0 0 298 336 1 1
    SPHK1 CLCF1 0 0 99 206 1 1
    SPHK1 CXCL13 0 0 293 293 1 1
    SPHK1 PLK1 0 0 160 159 1 1
    SPHK1 STARD7 0 0 74 235 1 1
    SPHK1 PPP2R2A 270 0 0 287 1 1
    SPHK1 PTGS1 0 0 174 204 1 1
    SPHK1 PRMT1 270 0 0 297 1 1
    SPHK1 NOTCH1 0 0 227 226 1 1
    SPHK1 FGF13 0 0 181 181 1 1
    SPHK1 SLC14A1 0 0 46 252 1 1
    SPHK1 KPNA1 0 0 45 204 1 1
    SPHK1 IL6 0 0 490 520 1 1
    SPHK1 LYVE1 0 0 244 264 1 1
    SPHK1 MPO 0 0 155 154 1 1
    SPHK1 BRMS1L 0 0 155 154 1 1
    SPHK1 TNFRSF1A 0 0 448 472 1 1
    SPHK1 DOCK7 0 0 0 208 1 1
    SPHK1 H3F3A 0 0 0 199 1 1
    SPHK1 MRPL1 0 0 0 176 1 1
    SPHK1 CCT5 0 600 0 621 1 1
    SPHK1 IL1B 0 0 459 476 1 1
    SPHK1 SP1 0 0 184 197 1 1
    SPHK1 EDN1 0 0 261 261 1 1
    SPHK1 HIF1A 0 0 402 424 1 2
    SPHK1 TRAF5 0 0 307 307 1 1
    SPHK1 PRKCB 0 900 107 915 1 2
    SPHK1 ACVR1C 0 0 0 155 1 1
    SPHK1 STAB1 0 0 146 277 1 1
    SPHK1 LIPE 0 0 91 167 1 1
    SPHK1 KLHL5 270 0 81 300 1 1
    SPHK1 CDK2 0 0 112 162 1 1
    SPHK1 ASPA 0 0 389 388 1 1
    SPHK1 PLA2G4A 0 0 302 342 1 1
    SPHK1 HSPB11 0 0 0 166 1 1
    SPHK1 RBM3 270 0 0 281 1 1
    SPHK1 SKIV2L 0 0 0 176 1 1
    SPHK1 ANKH 0 0 48 219 1 1
    SPHK1 ELAVL2 0 0 0 186 1 1
    SPHK1 ERN1 0 0 304 314 1 2
    SPHK1 PHLDA2 0 0 0 154 1 1
    SPHK1 STAT3 0 0 466 465 1 2
    SPHK1 EZH2 0 0 145 191 1 1
    SPHK1 KPNA4 0 0 0 208 1 1
    SPHK1 PRKCE 0 800 95 811 1 1
    SPHK1 COPB2 0 0 0 171 1 1
    SPHK1 GART 0 0 0 227 1 1
    SPHK1 MYD88 0 0 161 161 1 1
    SPHK1 CDK4 0 0 184 205 1 1
    SPHK1 STAU1 270 0 0 285 1 1
    SPHK1 FADD 0 0 103 158 1 2
    SPHK1 HK2 0 0 100 178 1 1
    SPHK1 TRAF1 0 0 397 415 1 1
    SPHK1 SLC2A2 0 0 58 213 1 1
    SPHK1 CSF3 0 0 155 179 1 1
    SPHK1 LIPN 0 0 0 161 1 1
    SPHK1 NGEF 0 0 0 302 1 1
    SPHK1 ANP32A 0 0 125 203 1 1
    SPHK1 S1PR2 0 0 885 895 1 1
    SPHK1 SAMD8 0 0 150 281 1 1
    SPHK1 TFR2 0 0 0 252 1 1
    SPHK1 TAX1BP1 0 0 306 306 1 2
    SPHK1 FHL2 270 0 751 835 1 1
    SPHK1 UCK1 0 0 0 161 1 1
    SPHK1 AKT2 0 0 134 174 1 1
    SPHK1 ACER3 0 900 556 965 1 1
    SPHK1 CTNND2 213 0 438 538 1 1
    SPHK1 METTL23 0 0 103 382 1 1
    SPHK1 MAP2K1 0 0 195 219 1 1
    SPHK1 PPIF 0 0 103 151 1 1
    SPHK1 F2RL1 0 0 729 729 1 1
    SPHK1 CH25H 0 0 90 259 1 1
    SPHK1 BTC 0 0 46 171 1 1
    SPHK1 CYB5A 0 0 94 176 1 1
    SPHK1 DDX47 0 0 54 386 1 1
    SPHK1 MYC 0 0 284 307 1 2
    SPHK1 IL1R1 0 0 157 229 1 1
    SPHK1 UBE2D1 0 0 435 447 1 1
    SPHK1 CIB3 0 0 66 151 1 1
    SPHK1 ZDHHC4 0 0 0 171 1 1
    SPHK1 IGF1R 0 0 207 238 1 1
    SPHK1 SMPDL3B 0 0 161 332 1 1
    SPHK1 NPC1 0 0 193 243 1 2
    SPHK1 MYH10 0 0 0 188 1 1
    SPHK1 TRAF2 675 0 891 986 1 1
    SPHK1 CIB2 0 0 365 365 1 1
    SPHK1 ACACA 270 0 48 275 1 1
    SPHK1 CERS1 0 0 501 501 1 1
    SPHK1 CASP9 0 0 220 220 1 1
    SPHK1 AGMO 0 0 0 219 1 1
    SPHK1 FASN 0 0 167 174 1 1
    SPHK1 SPTSSA 0 0 194 199 1 1
    SPHK1 IL17A 0 0 243 242 1 1
    SPHK1 STK16 0 0 0 390 1 1
    SPHK1 MFSD2A 0 0 0 254 1 1
    SPHK1 LUC7L2 0 0 0 486 1 1
    SPHK1 BPTF 0 0 0 386 1 1
    SPHK1 IER5L 0 0 0 174 1 1
    SPHK1 HIST2H3PS2 0 0 574 587 1 1
    SPHK1 HSPA6 0 0 107 158 1 1
    SPHK1 NR3C1 0 0 158 157 1 1
    SPHK1 PDGFA 0 900 166 914 1 1
    SPHK1 PTGER4 0 0 181 254 1 1
    SPHK1 HNRNPA2B1 270 0 53 290 1 1
    SPHK1 CTGF 0 0 307 334 1 1
    SPHK1 NSMAF 0 0 211 229 1 1
    SPHK1 ARG1 0 0 277 299 1 1
    SPHK1 GCLC 0 0 62 202 1 1
    SPHK1 ADIPOQ 0 0 213 213 1 1
    SPHK1 TARM1 0 0 183 211 1 1
    SPHK1 LTBP1 270 0 53 297 1 1
    SPHK1 CDK6 0 0 155 177 1 1
    SPHK1 HMGCS2 0 0 0 268 1 1
    SPHK1 SLC37A2 0 0 141 229 1 1
    SPHK1 CERS2 0 900 556 967 1 1
    SPHK1 PDPN 0 0 142 152 1 1
    SPHK1 PLG 0 0 233 232 1 1
    SPHK1 DEGS1 0 900 491 964 1 1
    SPHK1 ABCA1 0 0 342 488 1 1
    SPHK1 CPTP 0 0 322 399 1 1
    SPHK1 SPNS2 0 0 757 775 1 1
    SPHK1 GTPBP8 0 0 0 218 1 1
    SPHK1 IL1A 0 0 165 192 1 1
    SPHK1 PPM1G 488 0 0 510 1 1
    SPHK1 CASP8 0 0 213 213 1 2
    SPHK1 BAG2 270 0 0 270 1 1
    SPHK1 FLOT1 0 0 143 177 1 1
    SPHK1 ENSG00000267168 0 0 0 340 1 1
    SPHK1 CSNK2A2 0 0 90 188 1 1
    SPHK1 SLC22A17 0 0 67 208 1 1
    SPHK1 C6orf89 0 0 123 215 1 1
    SPHK1 ENPP2 0 0 394 455 1 1
    SPHK1 DBN1 270 0 0 275 1 1
    SPHK1 CIT 270 0 0 281 1 1
    SPHK1 INS 0 0 325 325 1 1
    SPHK1 ACP1 0 0 0 162 1 1
    SPHK1 CLDN5 0 0 136 151 1 1
    SPHK1 TMOD3 270 0 53 279 1 1
    SPHK1 ACTB 270 0 392 543 1 1
    SPHK1 CTTN 0 0 181 181 1 1
    SPHK1 PARM1 0 0 73 165 1 1
    SPHK1 GOT1 0 0 0 207 1 1
    SPHK1 ANGPT1 0 0 217 217 1 1
    SPHK1 MCM5 0 0 45 461 1 1
    SPHK1 FCGR2B 0 0 293 293 1 1
    SPHK1 DPP7 270 0 92 329 1 1
    SPHK1 ZNF580 0 0 134 153 1 1
    SPHK1 HSFX2 0 0 0 158 1 1
    SPHK1 VWA5B2 0 0 48 159 1 1
    SPHK1 PNPLA2 0 0 150 171 1 1
    SPHK1 IL3 0 0 144 150 1 1
    SPHK1 FOSL1 0 0 76 186 1 1
    SPHK1 SGPL1 0 900 704 984 1 1
    SPHK1 USP6 0 0 0 160 1 1
    SPHK1 ZEB1 0 0 167 167 1 1
    SPHK1 CCT4 0 600 57 646 1 1
    SPHK1 MYH9 270 0 0 404 1 1
    SPHK1 JUP 0 0 0 161 1 1
    SPHK1 OAT 270 0 0 330 1 1
    SPHK1 LLGL2 270 0 0 294 1 1
    SPHK1 RHOA 0 0 362 375 1 1
    SPHK1 PARP1 0 0 95 229 1 2
    SPHK1 HSPA8 270 0 0 275 1 2
    SPHK1 MOSPD3 0 0 0 152 1 1
    SPHK1 CXCL12 0 0 243 242 1 1
    SPHK1 UBE2N 0 0 442 454 1 1
    SPHK1 IL36A 0 0 73 158 1 1
    SPHK1 CD8A 0 0 205 205 1 1
    SPHK1 CYB5B 0 0 72 156 1 1
    SPHK1 IGFBP3 0 0 260 279 1 1
    SPHK1 EEF1A2 0 0 553 562 1 1
    SPHK1 MMP2 0 0 259 286 1 1
    SPHK1 MAT2A 0 0 113 173 1 1
    SPHK1 TCIRG1 0 0 0 151 1 1
    SPHK1 RASD1 0 0 0 189 1 1
    SPHK1 TNFRSF8 0 0 306 306 1 1
    SPHK1 ANGPT2 0 0 170 169 1 1
    SPHK1 TET3 0 0 0 189 1 1
    SPHK1 POLDIP3 0 0 0 544 1 1
    SPHK1 LUC7L 0 0 0 466 1 1
    SPHK1 COX17 0 0 81 220 1 1
    SPHK1 BCL2L11 0 0 260 260 1 1
    SPHK1 CD109 0 0 123 171 1 1
    SPHK1 KPNA6 0 0 0 201 1 1
    SPHK1 MGRN1 0 0 0 228 1 1
    SPHK1 BCS1L 0 0 0 194 1 1
    SPHK1 CCT8 0 600 0 617 1 1
    SPHK1 ITPR3 0 0 92 160 1 1
    SPHK1 PLCG1 0 900 123 908 1 1
    SPHK1 CASP1 0 0 166 165 1 2
    SPHK1 CHEK1 0 0 103 172 1 1
    SPHK1 KLK8 0 0 52 310 1 1
    SPHK1 PLAT 0 0 129 152 1 1
    SPHK1 PRPSAP2 0 0 0 400 1 1
    SPHK1 ELOVL4 0 0 125 205 1 1
    SPHK1 CAV1 0 0 266 319 1 1
    SPHK1 CERS5 0 900 517 964 1 1
    SPHK1 ORMDL3 0 0 278 405 1 1
    SPHK1 ENSG00000255767 0 0 0 162 1 1
    SPHK1 UCKL1 0 0 0 222 1 1
    SPHK1 CD4 0 0 284 284 1 1
    SPHK1 PRKCG 0 800 0 817 1 1
    SPHK1 PPARG 0 0 282 282 1 1
    SPHK1 AKT1 0 0 604 629 1 2
    SPHK1 GBP2 0 0 143 150 1 1
    SPHK1 IL12RB1 189 0 0 189 1 1
    SPHK1 KDSR 0 900 417 945 1 1
    SPHK1 ESM1 0 0 122 236 1 1
    SPHK1 RUNX2 0 0 156 155 1 1
    SPHK1 XIAP 0 0 157 156 1 1
    SPHK1 PPP2R4 0 0 202 202 1 1
    SPHK1 IKBKB 0 0 155 168 1 1
    SPHK1 ALAS1 0 0 0 154 1 1
    SPHK1 CXCL10 0 0 236 236 1 1
    SPHK1 IL11 0 0 195 215 1 1
    SPHK1 CDC16 0 0 0 189 1 1
    SPHK1 BIRC5 0 0 136 219 1 2
    SPHK1 ERBB2 0 0 294 304 1 2
    SPHK1 PTPLAD1 0 0 0 188 1 1
    SPHK1 SPRTN 0 0 0 276 1 1
    SPHK1 DSTN 270 0 0 270 1 1
    SPHK1 SCD 0 0 108 289 1 1
    SPHK1 RNASEH1 0 0 0 185 1 1
    SPHK1 SRC 105 0 379 457 1 1
    SPHK1 SMURF2 0 0 64 167 1 1
    SPHK1 MARCKSL1 270 0 0 271 1 1
    SPHK1 ERI2 0 0 97 215 1 1
    SPHK1 ACLY 0 0 144 162 1 1
    SPHK1 CIB1 0 0 240 336 1 1
    SPHK1 ALAS2 0 0 0 154 1 1
    SPHK1 PLSCR1 0 0 108 209 1 1
    SPHK1 FLT1 0 0 184 183 1 1
    SPHK1 LPAR4 0 0 431 440 1 1
    SPHK1 DGKB 0 0 154 204 1 1
    SPHK1 ANPEP 0 0 103 215 1 1
    SPHK1 HMOX1 0 0 202 240 1 2
    SPHK1 GLTP 0 0 150 155 1 1
    SPHK1 CDKN1B 0 0 155 162 1 2
    SPHK1 FN3KRP 0 0 92 250 1 1
    SPHK1 F2R 0 0 335 335 1 1
    SPHK1 ADORA2B 0 0 204 218 1 1
    SPHK1 HPRT1 0 0 160 167 1 1
    SPHK1 PITPNA 0 0 0 150 1 1
    SPHK1 BAK1 0 0 150 257 1 2
    SPHK1 PGS1 0 0 0 151 1 1
    SPHK1 DDX5 0 0 64 362 1 1
    SPHK1 CAT 0 0 142 194 1 1
    SPHK1 WNT10B 0 0 150 219 1 1
    SPHK1 MKL2 0 0 60 268 1 1
    SPHK1 PDPK1 0 0 0 162 1 2
    SPHK1 EMP1 0 0 112 181 1 1
    SPHK1 SGPP2 0 900 681 979 1 1
    SPHK1 PSMA3 270 0 0 270 1 1
    SPHK1 BMPR2 0 0 107 164 1 1
    SPHK1 CCT6A 0 600 0 612 1 1
    SPHK1 RASA1 0 900 0 900 1 1
    SPHK1 CDIPT 0 0 70 215 1 1
    SPHK1 OSBPL10 0 0 0 167 1 1
    SPHK1 STXBP3 0 0 0 364 1 1
    SPHK1 HGF 0 0 218 218 1 1
    SPHK1 NTRK1 0 0 181 193 1 1
    SPHK1 LOX 0 0 182 223 1 1
    SPHK1 SAG 0 0 195 195 1 1
    SPHK1 DDX60 0 0 0 202 1 1
    SPHK1 SGK1 0 0 113 203 1 1
    SPHK1 FCGR1A 0 0 213 213 1 1
    SPHK1 RPS6KB1 0 0 181 264 1 2
    SPHK1 SERPINE1 0 0 260 350 1 1
    SPHK1 LPGAT1 0 0 70 233 1 1
    SPHK1 SRP68 0 0 82 440 1 1
    SPHK1 PGR 0 0 142 164 1 1
    SPHK1 CDK1 0 0 148 194 1 1
    SPHK1 APEH 0 0 321 328 1 1
    SPHK1 HSF2 0 0 0 158 1 1
    SPHK1 STAR 0 0 61 156 1 1
    SPHK1 ABCG2 0 0 293 298 1 1
    SPHK1 SUPT5H 0 0 0 160 1 1
    SPHK1 TFRC 0 0 109 184 1 1
    SPHK1 ACER2 0 900 519 962 1 1
    SPHK1 TNFAIP3 0 0 293 318 1 1
    SPHK1 NFKB2 0 0 61 158 1 1
    SPHK1 DOCK6 0 0 47 212 1 1
    SPHK1 TCP1 0 600 57 621 1 1
    SPHK1 AGK 0 0 647 294 1 1
    SPHK1 LIPF 0 0 0 161 1 1
    SPHK1 NAPEPLD 0 0 0 153 1 1
    SPHK1 N4BP2 0 0 0 201 1 1
    SPHK1 CDH5 0 0 295 295 1 1
    SPHK1 NT5E 0 0 94 185 1 1
    SPHK1 VAPB 0 0 0 153 1 1
    SPHK1 MMP3 0 0 158 189 1 1
    SPHK1 CGI-74 0 0 0 486 1 1
    SPHK1 LPIN2 0 0 170 260 1 1
    SPHK1 FBXO18 0 0 0 153 1 1
    SPHK1 TNF 0 0 591 635 1 1
    SPHK1 LINS 0 0 0 172 1 1
    SPHK1 SLC22A7 0 0 70 221 1 1
    SPHK1 DDX17 0 0 0 347 1 1
    SPHK1 ESR1 0 0 483 483 1 1
    SPHK1 IFNB1 0 0 168 167 1 1
    SPHK1 CSRP1 270 0 0 270 1 1
    SPHK1 ST8SIA2 0 0 0 173 1 1
    SPHK1 TSPYL5 0 0 73 295 1 1
    SPHK1 KHK 0 0 83 232 1 1
    SPHK1 BAI1 0 0 213 213 1 1
    SPHK1 RGS2 0 0 89 151 1 1
    SPHK1 PTDSS2 0 0 100 225 1 1
    SPHK1 PLCD1 0 0 96 260 1 1
    SPHK1 IRF1 0 0 362 362 1 1
    SPHK1 PRKD1 0 0 193 216 1 1
    SPHK1 ILKAP 0 0 0 150 1 1
    SPHK1 PPT1 0 0 63 157 1 1
    SPHK1 HSF4 0 0 0 158 1 1
    SPHK1 TIMP2 0 0 150 178 1 1
    SPHK1 SPHK2 0 800 913 822 1 1
    SPHK1 AGPAT4 0 0 0 210 1 1
    SPHK1 TERT 0 0 117 457 1 1
    SPHK1 LPAR2 0 0 323 328 1 1
    SPHK1 MMP13 0 0 134 152 1 1
    SPHK1 FN1 0 0 360 380 1 1
    SPHK1 LPAR6 0 0 260 273 1 1
    SPHK1 TM4SF1 0 0 210 248 1 1
    SPHK1 PRKCA 0 900 315 934 1 1
    SPHK1 CCL3 0 0 165 165 1 1
    SPHK1 UBE2O 0 0 118 629 1 1
    SPHK1 LITAF 0 0 73 202 1 1
    SPHK1 COL4A3BP 0 0 394 496 1 1
    SPHK1 BRMS1 0 0 164 174 1 1
    SPHK1 SULT2B1 0 0 0 197 1 1
    SPHK1 STRADB 0 0 119 159 1 1
    SPHK1 SNAI1 0 0 170 222 1 1
    SPHK1 IL10 189 0 341 443 1 1
    SPHK1 MS4A2 0 900 0 900 1 1
    SPHK1 CERK 0 0 688 333 1 1
    SPHK1 FAR2 0 0 60 182 1 1
    SPHK1 FCGR2A 0 0 155 154 1 1
    SPHK1 B3GNT5 0 0 137 215 1 1
    SPHK1 MRPL45 0 0 0 185 1 1
    SPHK1 ACY1 0 0 644 659 1 1
    SPHK1 KIT 0 0 170 169 1 1
    SPHK1 TRMT61A 0 0 0 168 1 1
    SPHK1 ACER1 0 900 518 961 1 1
    SPHK1 GPER1 0 0 151 150 1 1
    SPHK1 ASAH1 0 900 687 970 1 1
    SPHK1 IL13 0 0 247 246 1 1
    SPHK1 DDX60L 0 0 0 202 1 1
    SPHK1 ABCA7 0 0 171 177 1 1
    SPHK1 VEGFC 0 0 242 287 1 1
    SPHK1 HP1BP3 270 0 0 270 1 1
    SPHK1 PPME1 0 0 0 164 1 1
    SPHK1 KCNMB4 0 0 0 188 1 1
    SPHK1 CYBB 0 0 208 208 1 1
    SPHK1 NLRP3 0 0 166 165 1 2
    SPHK1 PLA2G6 0 0 147 191 1 1
    SPHK1 NCAPH 0 0 0 254 1 1
    SPHK1 PSMB6 270 0 0 372 1 1
    SPHK1 PLD2 0 800 243 861 1 1
    SPHK1 PTGS2 0 0 455 480 1 1
    SPHK1 CASP3 0 0 420 420 1 2
    SPHK1 F3 0 0 163 163 1 1
    SPHK1 ADAT3 0 0 0 204 1 1
    SPHK1 NYAP2 0 0 96 158 1 1
    SPHK1 SMPD1 0 0 651 714 1 1
    SPHK1 SGMS2 0 0 391 453 1 1
    SPHK1 CEBPB 0 0 107 160 1 1
    SPHK1 WDR91 0 0 0 156 1 1
    SPHK1 RIPK1 0 0 328 338 1 1
    SPHK1 PRODH2 0 0 0 184 1 1
    SPHK1 GSK3B 0 0 245 266 1 2
    SPHK1 MRC1 0 0 261 261 1 1
    SPHK1 CDKN2A 0 0 142 186 1 2
    SPHK1 ST3GAL5 0 0 56 155 1 1
    SPHK1 EPHB2 0 0 86 196 1 2
    SPHK1 AGPAT2 0 0 95 174 1 1
    SPHK1 AKAP3 0 0 520 520 1 1
    SPHK1 ADAM15 0 0 90 188 1 1
    SPHK1 JMJD6 0 0 53 311 1 1
    SPHK1 TKT 0 0 375 375 1 1
    SPHK1 ANAPC10 0 0 0 166 1 1
    SPHK1 SVIL 270 0 0 270 1 1
    SPHK1 ASAH2 0 900 667 975 1 1
    SPHK1 KRAS 0 900 166 919 1 1
    SPHK1 S100A13 0 0 459 493 1 1
    SPHK1 SOCS3 0 0 142 167 1 1
    SPHK1 FASLG 0 0 154 153 1 1
    SPHK1 CCT7 0 600 82 644 1 1
    SPHK1 MYO1C 270 0 58 445 1 1
    SPHK1 SCD5 0 0 0 236 1 1
    SPHK1 KIAA1147 0 0 0 248 1 1
    SPHK1 LPIN1 0 0 171 261 1 2
    SPHK1 PSMD2 0 0 0 270 1 1
    SPHK1 CCT6B 0 600 0 612 1 1
    SPHK1 ABCC1 0 0 504 590 1 1
    SPHK1 IL2 0 0 166 165 1 1
    SPHK1 ANXA1 0 0 155 208 1 1
    SPHK1 ABCB1 0 0 181 230 1 1
    SPHK1 THBS1 0 0 206 245 1 1
    SPHK1 ENSG00000262660 0 0 0 212 1 1
    SPHK1 KANK2 0 0 54 321 1 1
    SPHK1 BECN1 270 0 241 449 1 2
    SPHK1 PTGER3 0 0 150 236 1 1
    SPHK1 ELAVL4 0 0 0 186 1 1
    SPHK1 DUSP1 0 0 122 176 1 1
    SPHK1 SNRNP25 0 0 113 514 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005524 Molecular Function ATP binding enables IDA
    GO:0017050 Molecular Function D-erythro-sphingosine kinase activity enables IBA
    GO:0017050 Molecular Function D-erythro-sphingosine kinase activity enables IDA
    GO:0017050 Molecular Function D-erythro-sphingosine kinase activity enables TAS
    GO:0003677 Molecular Function DNA binding enables IDA
    GO:0016407 Molecular Function acetyltransferase activity enables ISS
    GO:0005516 Molecular Function calmodulin binding enables IDA
    GO:0008289 Molecular Function lipid binding enables IDA
    GO:0001727 Molecular Function lipid kinase activity enables TAS
    GO:0000287 Molecular Function magnesium ion binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0051721 Molecular Function protein phosphatase 2A binding enables IPI
    GO:0008481 Molecular Function sphingosine kinase activity enables IDA
    GO:0038036 Molecular Function sphingosine-1-phosphate receptor activity enables IMP
    GO:0071897 Biological Process DNA biosynthetic process involved_in IEA
    GO:0001568 Biological Process blood vessel development involved_in IEA
    GO:0007420 Biological Process brain development involved_in IEA
    GO:0019722 Biological Process calcium-mediated signaling involved_in IDA
    GO:0008283 Biological Process cell population proliferation involved_in IEA
    GO:0071363 Biological Process cellular response to growth factor stimulus involved_in IBA
    GO:0070301 Biological Process cellular response to hydrogen peroxide involved_in IEA
    GO:0035924 Biological Process cellular response to vascular endothelial growth factor stimulus involved_in IDA
    GO:0006954 Biological Process inflammatory response involved_in IEA
    GO:0035556 Biological Process intracellular signal transduction involved_in TAS
    GO:0043066 Biological Process negative regulation of apoptotic process involved_in IBA
    GO:0043066 Biological Process negative regulation of apoptotic process acts_upstream_of_or_within IDA
    GO:0043066 Biological Process negative regulation of apoptotic process involved_in IMP
    GO:0043066 Biological Process negative regulation of apoptotic process involved_in TAS
    GO:1900060 Biological Process negative regulation of ceramide biosynthetic process involved_in IDA
    GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IMP
    GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in ISS
    GO:0045766 Biological Process positive regulation of angiogenesis involved_in IDA
    GO:0030307 Biological Process positive regulation of cell growth involved_in IDA
    GO:0030335 Biological Process positive regulation of cell migration involved_in IDA
    GO:0048146 Biological Process positive regulation of fibroblast proliferation acts_upstream_of_or_within IDA
    GO:0032740 Biological Process positive regulation of interleukin-17 production involved_in ISS
    GO:0045931 Biological Process positive regulation of mitotic cell cycle involved_in IDA
    GO:0045840 Biological Process positive regulation of mitotic nuclear division involved_in IEA
    GO:1901224 Biological Process positive regulation of non-canonical NF-kappaB signal transduction involved_in IMP
    GO:1900745 Biological Process positive regulation of p38MAPK cascade involved_in IDA
    GO:0010800 Biological Process positive regulation of peptidyl-threonine phosphorylation involved_in IMP
    GO:0031398 Biological Process positive regulation of protein ubiquitination involved_in IDA
    GO:0045987 Biological Process positive regulation of smooth muscle contraction involved_in IDA
    GO:0006473 Biological Process protein acetylation involved_in ISS
    GO:0030100 Biological Process regulation of endocytosis involved_in IDA
    GO:1905364 Biological Process regulation of endosomal vesicle fusion involved_in ISS
    GO:0032651 Biological Process regulation of interleukin-1 beta production involved_in IEA
    GO:1903978 Biological Process regulation of microglial cell activation involved_in ISS
    GO:0150077 Biological Process regulation of neuroinflammatory response involved_in ISS
    GO:0050764 Biological Process regulation of phagocytosis involved_in ISS
    GO:0010803 Biological Process regulation of tumor necrosis factor-mediated signaling pathway involved_in IDA
    GO:0034612 Biological Process response to tumor necrosis factor involved_in IDA
    GO:0046521 Biological Process sphingoid catabolic process involved_in NAS
    GO:0030148 Biological Process sphingolipid biosynthetic process involved_in TAS
    GO:0046512 Biological Process sphingosine biosynthetic process involved_in IBA
    GO:0046512 Biological Process sphingosine biosynthetic process involved_in IGI
    GO:0046512 Biological Process sphingosine biosynthetic process involved_in IMP
    GO:0006670 Biological Process sphingosine metabolic process involved_in IDA
    GO:0003376 Biological Process sphingosine-1-phosphate receptor signaling pathway involved_in IEA
    GO:0005929 Cellular Component cilium located_in IDA
    GO:0005905 Cellular Component clathrin-coated pit located_in IDA
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0031901 Cellular Component early endosome membrane located_in IDA
    GO:0030139 Cellular Component endocytic vesicle located_in ISS
    GO:0043231 Cellular Component intracellular membrane-bounded organelle is_active_in IBA
    GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
    GO:0016020 Cellular Component membrane is_active_in IBA
    GO:0005654 Cellular Component nucleoplasm located_in TAS
    GO:0005634 Cellular Component nucleus located_in ISS
    GO:0005886 Cellular Component plasma membrane located_in IDA
    GO:0098793 Cellular Component presynapse is_active_in IDA
    GO:0098793 Cellular Component presynapse is_active_in IMP
    GO:0098793 Cellular Component presynapse located_in ISS
    Pathways
    Name DB ID
    Metabolism Reactome R-HSA-1430728
    Signal Transduction Reactome R-HSA-162582
    Sphingolipid de novo biosynthesis Reactome R-HSA-1660661
    Signaling by VEGF Reactome R-HSA-194138
    Chaperonin-mediated protein folding Reactome R-HSA-390466
    Association of TriC/CCT with target proteins during biosynthesis Reactome R-HSA-390471
    Protein folding Reactome R-HSA-391251
    Metabolism of proteins Reactome R-HSA-392499
    Sphingolipid metabolism Reactome R-HSA-428157
    VEGFA-VEGFR2 Pathway Reactome R-HSA-4420097
    VEGFR2 mediated cell proliferation Reactome R-HSA-5218921
    Metabolism of lipids Reactome R-HSA-556833
    ESR-mediated signaling Reactome R-HSA-8939211
    Signaling by Nuclear Receptors Reactome R-HSA-9006931
    Signaling by Receptor Tyrosine Kinases Reactome R-HSA-9006934
    Extra-nuclear estrogen signaling Reactome R-HSA-9009391
    Sphingolipid metabolism: integrated pathway (WP4726) WikiPathways WP4726_r124753
    Sphingolipid metabolism in senescence (WP5121) WikiPathways WP5121_r119472
    Sphingolipid metabolism overview (WP4725) WikiPathways WP4725_r124751
    Biosynthesis and turnover of 1-deoxy-sphingoid bases (WP5179) WikiPathways WP5179_r121899
    S1P receptor signal transduction (WP26) WikiPathways WP26_r118660
    Sphingolipid pathway (WP1422) WikiPathways WP1422_r118359
    Metabolism of sphingolipids in ER and Golgi apparatus (WP4142) WikiPathways WP4142_r124466
    Synthesis of ceramides and 1-deoxyceramides (WP5194) WikiPathways WP5194_r122165
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001355139 2 mRNA transcript variant 5 NC_000017 Reference
    NM_182965 3 mRNA transcript variant 2 NC_000017 Reference
    NM_021972 4 mRNA transcript variant 1 NC_000017 Reference
    NM_001142601 2 mRNA transcript variant 3 NC_000017 Reference
    NM_001142602 2 mRNA transcript variant 4 NC_000017 Reference