FADD

Fas associated via death domain
General Information
Name Fas associated via death domain
Alias
  • FAS-associated death domain protein
  • Fas (TNFRSF6)-associated via death domain
  • Fas-associating death domain-containing protein
  • Fas-associating protein with death domain
  • growth-inhibiting gene 3 protein
  • mediator of receptor-induced toxicity
Synonyms MORT1 GIG3 IMD90
Gene_family Death effector domain containing|Death inducing signaling complex |Ripoptosome
organism Homo sapiens
entrez_id 8772
location 11q13.3
transcript_count 1
exon_count 2
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
      Stringdb FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling; Death effector domain containing
      nextProt Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors (PubMed:7538907, PubMed:23955153, PubMed:19118384, PubMed:20935634, PubMed:16762833, PubMed:24025841). The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation (PubMed:7538907, PubMed:19118384, PubMed:20935634, PubMed:16762833). Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    FADD BioGRID BRCA1 GeneID BioGRID Co-localization
    FADD BioGRID CDH1 GeneID BioGRID Reconstituted Complex
    FADD BioGRID CDC27 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID CDC20 GeneID BioGRID Reconstituted Complex
    FADD BioGRID RIPK3 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID RIPK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid
    FADD BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    FADD BioGRID CASP8 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex; Two-hybrid
    FADD BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western; Co-fractionation
    FADD BioGRID ANKRD13A GeneID BioGRID Affinity Capture-Western
    FADD BioGRID IL37 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID SDS GeneID BioGRID Affinity Capture-MS
    FADD BioGRID FAS GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Co-purification; Reconstituted Complex; Two-hybrid
    FADD BioGRID CFLAR GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    FADD BioGRID TNFRSF10A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization
    FADD BioGRID TNFRSF10B GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-purification
    FADD BioGRID THAP12 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID NTF4 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID SKP2 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID TRADD GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
    FADD BioGRID TNFSF10 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID IRF3 GeneID BioGRID Negative Genetic
    FADD BioGRID E2F4 GeneID BioGRID Positive Genetic
    FADD BioGRID BTK GeneID BioGRID Negative Genetic
    FADD BioGRID HSPD1 GeneID BioGRID Proximity Label-MS
    FADD BioGRID ZCCHC12 GeneID BioGRID Two-hybrid
    FADD BioGRID DDIT4L GeneID BioGRID Two-hybrid
    FADD BioGRID NUTM2F GeneID BioGRID Two-hybrid
    FADD BioGRID ZMYM5 GeneID BioGRID Two-hybrid
    FADD BioGRID FADD GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
    FADD BioGRID UBE2I GeneID BioGRID Two-hybrid
    FADD BioGRID TCEA2 GeneID BioGRID Two-hybrid
    FADD BioGRID SDCBP GeneID BioGRID Two-hybrid
    FADD BioGRID RNF4 GeneID BioGRID Two-hybrid
    FADD BioGRID BTG1 GeneID BioGRID Two-hybrid
    FADD BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID TRPC6 GeneID BioGRID Positive Genetic
    FADD BioGRID ROBO2 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID IGHA1 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID CSNK1D GeneID BioGRID Affinity Capture-MS
    FADD BioGRID CSNK1A1 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID CHUK GeneID BioGRID Affinity Capture-MS
    FADD BioGRID ACTG1 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID CKMT1A GeneID BioGRID Affinity Capture-MS
    FADD BioGRID GOLGA7B GeneID BioGRID Affinity Capture-MS
    FADD BioGRID CCDC50 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID DNAAF1 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID NDNF GeneID BioGRID Affinity Capture-MS
    FADD BioGRID EPB41L4B GeneID BioGRID Affinity Capture-MS
    FADD BioGRID SDK2 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID ULK3 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID SLC7A11 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID RHOQ GeneID BioGRID Affinity Capture-MS
    FADD BioGRID NUP42 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID KIF2C GeneID BioGRID Affinity Capture-MS
    FADD BioGRID PRDX4 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID TNIP1 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID RNF41 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID TANK GeneID BioGRID Affinity Capture-MS
    FADD BioGRID S1PR2 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID AKR7A2 GeneID BioGRID Affinity Capture-MS
    FADD BioGRID IKBKG GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    FADD BioGRID TNFAIP3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    FADD BioGRID E6 GeneID BioGRID Reconstituted Complex; Two-hybrid
    FADD BioGRID STUB1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    FADD BioGRID SPOP GeneID BioGRID Affinity Capture-Western; Two-hybrid
    FADD BioGRID PIN1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    FADD BioGRID TPPP GeneID BioGRID Affinity Capture-MS
    FADD BioGRID TLR3 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID NLRC4 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID HHV8GK18_gp80 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID EZR GeneID BioGRID Affinity Capture-MS; Co-localization; Co-purification
    FADD BioGRID DAPK1 GeneID BioGRID Affinity Capture-Western; Co-localization
    FADD BioGRID BID GeneID BioGRID Co-localization; Co-purification
    FADD BioGRID RHOA GeneID BioGRID Co-localization; Co-purification
    FADD BioGRID FASLG GeneID BioGRID Affinity Capture-Western; Co-localization; Co-purification
    FADD BioGRID RAP1A GeneID BioGRID Reconstituted Complex
    FADD BioGRID Naca GeneID BioGRID Affinity Capture-Western
    FADD BioGRID NAXE GeneID BioGRID Co-fractionation
    FADD BioGRID EHD1 GeneID BioGRID Co-fractionation
    FADD BioGRID NEFH GeneID BioGRID Affinity Capture-MS
    FADD BioGRID NACA GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    FADD BioGRID CASP10 GeneID BioGRID Affinity Capture-Western; Co-purification; FRET; Reconstituted Complex; Two-hybrid
    FADD BioGRID ATG5 GeneID BioGRID Affinity Capture-Western; Co-localization; Reconstituted Complex
    FADD BioGRID ATG12 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID TNF GeneID BioGRID Affinity Capture-Western
    FADD BioGRID TNFRSF1A GeneID BioGRID Affinity Capture-Western; Co-purification
    FADD BioGRID MYD88 GeneID BioGRID Two-hybrid
    FADD BioGRID MKRN1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    FADD BioGRID CUL3 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID Fas GeneID BioGRID Two-hybrid
    FADD BioGRID PARK7 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    FADD BioGRID LRRK2 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID FAF1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    FADD BioGRID EDAR GeneID BioGRID Affinity Capture-Western
    FADD BioGRID CLIP3 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID DAXX GeneID BioGRID Affinity Capture-Western
    FADD BioGRID MAVS GeneID BioGRID Affinity Capture-Western
    FADD BioGRID KHDRBS1 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID TAB1 GeneID BioGRID Two-hybrid
    FADD BioGRID TRIM21 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    FADD BioGRID IRF7 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID RALGDS GeneID BioGRID Affinity Capture-Western
    FADD BioGRID PIDD1 GeneID BioGRID Affinity Capture-Western
    FADD Protein PIDD1 GeneID HPRD None
    FADD Protein LRRCC1 GeneID HPRD None
    FADD Protein MOB4 GeneID HPRD None
    FADD Protein RYBP GeneID HPRD None
    FADD Protein RALBP1 GeneID HPRD None
    FADD Protein XPO5 GeneID HPRD None
    FADD Protein CASP8AP2 GeneID HPRD None
    FADD Protein DEDD GeneID HPRD None
    FADD Protein DDX24 GeneID HPRD None
    FADD Protein NOL3 GeneID HPRD None
    FADD Protein FAF1 GeneID HPRD None
    FADD Protein HIPK3 GeneID HPRD None
    FADD Protein TNFRSF10B GeneID HPRD None
    FADD Protein TNFRSF10A GeneID HPRD None
    FADD Protein CFLAR GeneID HPRD None
    FADD Protein MBD4 GeneID HPRD None
    FADD Protein TRADD GeneID HPRD None
    FADD Protein RIPK1 GeneID HPRD None
    FADD Protein PEA15 GeneID HPRD None
    FADD Protein MYD88 GeneID HPRD None
    FADD Protein DAP3 GeneID HPRD None
    FADD Protein TRAF2 GeneID HPRD None
    FADD Protein CASP8 GeneID HPRD None
    FADD Protein CASP10 GeneID HPRD None
    FADD Protein NACA GeneID HPRD None
    FADD Protein DAPK1 GeneID HPRD None
    FADD Protein STAT1 GeneID HPRD None
    FADD Protein CSNK1A1 GeneID HPRD None
    FADD Protein ANK3 GeneID HPRD None
    FADD Protein PTPN13 GeneID HPRD None
    FADD Protein ABCA1 GeneID HPRD None
    FADD Protein IRAK1 GeneID HPRD None
    FADD Protein EDA2R GeneID HPRD None
    FADD Protein IKBKG GeneID HPRD None
    FADD Protein RAP1A GeneID HPRD None
    FADD Protein PRKCZ GeneID HPRD None
    FADD Protein FASLG GeneID HPRD None
    FADD Protein FAS GeneID HPRD None
    FADD BioGRID DEDD GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    FADD BioGRID CASP8AP2 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID NOL3 GeneID BioGRID Phenotypic Suppression
    FADD BioGRID DAP3 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    FADD BioGRID RYBP GeneID BioGRID Affinity Capture-Western
    FADD BioGRID HIPK3 GeneID BioGRID Affinity Capture-Western
    FADD BioGRID MBD4 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    FADD BioGRID PEA15 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    FADD BioGRID PRKCZ GeneID BioGRID Affinity Capture-Western
    FADD BioGRID ABCA1 GeneID BioGRID Reconstituted Complex; Two-hybrid
    FADD BioGRID MOB4 GeneID BioGRID Two-hybrid
    FADD BioGRID MAPK8 GeneID BioGRID Co-purification
    FADD BioGRID MSN GeneID BioGRID Co-purification
    FADD BioGRID ARHGDIA GeneID BioGRID Co-purification
    FADD Protein CASP8 GeneID BIND CASP8 (caspase-8) interacts with FADD.
    FADD Protein TRADD GeneID BIND TRADD interacts with FADD.
    FADD Protein FAS GeneID BIND An unspecified isoform of Fas interacts with FADD.
    FADD Protein NOL3 GeneID BIND ARC interacts with FADD.
    FADD Protein CFLAR GeneID BIND MRIT-beta-1 interacts with FADD. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and FADD from an unspecified species.
    FADD Protein TRADD GeneID BIND TRADD interacts with FADD. This interaction was modeled on a demonstrated interaction between TRADD and FADD, both from an unspecified species
    FADD Protein FAS GeneID BIND Fas interacts with FADD.
    FADD Protein TRADD GeneID BIND FADD interacts with TRADD.
    FADD Protein CASP8 GeneID BIND caspase-8 interacts with FADD.
    FADD Protein CFLAR GeneID BIND c-FLIP interacts with FADD.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    FADD BTRC 0 0 143 162 1 1
    FADD CASP14 0 0 293 361 1 1
    FADD HSPA5 0 0 334 334 1 2
    FADD IFNGR1 0 0 134 264 1 1
    FADD SOD2 0 0 211 211 1 1
    FADD ADRBK1 0 0 47 180 1 1
    FADD FOXO1 0 0 203 220 1 2
    FADD KRAS 0 0 240 303 1 1
    FADD SOCS3 0 0 180 179 1 1
    FADD DDX24 0 0 357 371 1 1
    FADD FASLG 870 900 988 999 1 1
    FADD FOS 0 0 325 325 1 1
    FADD TNIP2 0 0 173 234 1 1
    FADD XAF1 0 0 202 202 1 1
    FADD FAF1 270 900 825 986 1 1
    FADD IRAK3 0 0 173 197 1 1
    FADD TNIP1 192 0 271 442 1 1
    FADD STAT5A 0 0 202 202 1 1
    FADD TADA3 0 0 161 161 1 1
    FADD BIRC7 0 0 409 485 1 1
    FADD CDC25A 0 0 150 175 1 1
    FADD TBKBP1 0 0 202 202 1 1
    FADD CD86 0 0 194 194 1 1
    FADD CARD11 0 0 267 378 1 1
    FADD NOD1 0 0 323 323 1 1
    FADD TTLL4 0 0 45 170 1 1
    FADD CD81 0 0 70 164 1 1
    FADD DAD1 0 0 88 159 1 1
    FADD NIF3L1 0 0 105 181 1 1
    FADD PSMD2 0 0 95 158 1 1
    FADD SHARPIN 0 0 469 499 1 1
    FADD TLR6 0 0 219 264 1 1
    FADD IL2 0 0 322 321 1 1
    FADD BECN1 0 0 626 645 1 2
    FADD SDC1 0 0 132 159 1 1
    FADD KANK2 0 0 150 163 1 1
    FADD OTUD7B 0 900 141 911 1 1
    FADD HSH2D 0 0 269 269 1 1
    FADD TOLLIP 0 0 223 294 1 1
    FADD CDKN2C 0 0 120 239 1 1
    FADD MLH1 0 0 808 809 1 1
    FADD LRRK2 270 0 853 899 1 2
    FADD CPSF3 0 0 306 310 1 1
    FADD TRAF3 0 0 673 681 1 2
    FADD ERF 0 0 0 155 1 1
    FADD MET 0 0 123 187 1 1
    FADD PEA15 486 0 988 994 1 1
    FADD MAPK11 0 0 157 188 1 1
    FADD TLR2 0 0 391 400 1 1
    FADD CDKN2B 0 0 166 201 1 1
    FADD PMAIP1 0 0 518 519 1 1
    FADD IL13 0 0 202 202 1 1
    FADD TNFRSF10B 870 900 989 999 1 1
    FADD ATG12 270 0 524 675 1 2
    FADD TNFSF13B 0 0 205 205 1 1
    FADD PPM1B 0 0 151 204 1 1
    FADD PPIA 0 0 134 175 1 1
    FADD DIRAS3 0 0 451 451 1 2
    FADD NR2C2 0 0 142 174 1 1
    FADD CD28 0 0 252 252 1 1
    FADD DTX3 0 0 0 207 1 1
    FADD CYBB 0 0 276 276 1 1
    FADD EDA2R 270 0 90 307 1 1
    FADD CARD16 0 0 350 432 1 1
    FADD NLRP3 0 0 577 604 1 2
    FADD REL 0 0 374 376 1 1
    FADD ATG101 0 0 124 177 1 2
    FADD UBE2V1 0 0 181 209 1 1
    FADD IL33 0 0 150 168 1 1
    FADD ATG4D 0 0 165 179 1 2
    FADD CXCL1 0 0 180 194 1 1
    FADD CASP3 0 900 829 986 1 2
    FADD ERBB3 0 0 165 165 1 1
    FADD PTGS2 0 0 325 325 1 1
    FADD FGF19 0 0 286 286 1 1
    FADD TNFRSF21 0 0 507 516 1 1
    FADD PGLYRP1 0 0 145 186 1 1
    FADD MBD4 270 0 834 874 1 1
    FADD DAXX 270 900 536 964 1 1
    FADD DHFR 0 0 67 401 1 1
    FADD ATG16L1 0 0 228 341 1 2
    FADD SMPD1 0 900 322 929 1 1
    FADD CEBPB 0 0 170 195 1 1
    FADD NOD2 0 0 294 294 1 1
    FADD CSF1 0 0 159 158 1 1
    FADD RIPK1 913 900 989 999 1 1
    FADD HDAC1 0 0 149 180 1 2
    FADD LTBR 0 0 336 350 1 1
    FADD ITGAX 0 0 162 176 1 1
    FADD GSK3B 0 0 150 214 1 2
    FADD MTCH2 0 0 52 154 1 1
    FADD CASP4 0 0 402 471 1 2
    FADD CDKN2A 0 0 325 335 1 2
    FADD CHUK 192 900 720 976 1 1
    FADD CUL3 270 0 245 432 1 1
    FADD KIFAP3 0 0 386 386 1 1
    FADD MDM4 0 0 125 161 1 1
    FADD CCL3 0 0 181 181 1 1
    FADD LITAF 0 0 134 187 1 1
    FADD DAP 0 0 71 194 1 2
    FADD SHC1 0 0 166 186 1 1
    FADD ATM 0 0 324 323 1 1
    FADD EZR 747 900 128 976 1 1
    FADD PON2 0 0 181 198 1 1
    FADD CTSD 0 0 235 257 1 2
    FADD TNFRSF10C 0 0 603 825 1 1
    FADD RYBP 270 0 373 523 1 1
    FADD IRAK4 0 0 391 412 1 1
    FADD RBPJ 0 0 63 168 1 1
    FADD DAPK2 0 0 134 182 1 2
    FADD IL10 0 0 348 347 1 1
    FADD NCK1 0 0 64 177 1 1
    FADD CLIP3 270 0 456 586 1 1
    FADD ACTG1 192 0 140 306 1 1
    FADD FAIM2 0 0 572 572 1 1
    FADD TRAIP 0 0 411 425 1 1
    FADD DYRK1B 0 0 384 394 1 1
    FADD ATG7 0 0 360 469 1 2
    FADD CCAR1 0 0 87 230 1 1
    FADD TGFBR2 0 0 150 174 1 1
    FADD DUSP28 0 0 457 457 1 1
    FADD CERK 0 0 49 304 1 1
    FADD CASP5 0 0 391 461 1 1
    FADD DNM1L 0 0 260 260 1 2
    FADD TRAF7 0 0 379 401 1 1
    FADD NEK7 0 0 197 252 1 1
    FADD PTEN 0 0 486 486 1 2
    FADD ACSL4 0 0 108 263 1 1
    FADD PLBD1 0 0 135 197 1 1
    FADD GABARAP 0 0 74 194 1 2
    FADD VEGFA 0 0 335 335 1 1
    FADD NLRP6 0 0 204 204 1 1
    FADD AKR7A2 192 0 0 213 1 1
    FADD MAPK10 0 0 204 204 1 2
    FADD E2F3 0 0 134 169 1 1
    FADD NGFR 0 800 672 931 1 1
    FADD BAG1 0 0 243 242 1 2
    FADD TP53BP2 0 0 181 186 1 1
    FADD MAPK14 0 0 294 342 1 1
    FADD LMNB2 0 0 180 220 1 1
    FADD TIMP3 0 0 161 161 1 1
    FADD TNFRSF9 0 0 193 193 1 1
    FADD CLEC4E 0 0 166 165 1 1
    FADD NFKBIA 0 0 560 567 1 1
    FADD KIT 0 0 170 169 1 1
    FADD SYK 0 0 211 251 1 1
    FADD AMBRA1 0 0 164 178 1 2
    FADD TRMT61A 0 0 0 154 1 1
    FADD MAP3K3 0 0 142 175 1 1
    FADD NKAP 0 0 413 422 1 1
    FADD IFNB1 0 0 500 499 1 1
    FADD HMGB1 0 0 297 297 1 2
    FADD IRF5 0 0 231 230 1 1
    FADD ESR1 0 0 247 246 1 1
    FADD DFNA5 0 0 174 173 1 1
    FADD LYN 0 0 206 229 1 1
    FADD ITGAM 0 0 216 229 1 1
    FADD SMAD7 0 0 146 165 1 1
    FADD PSMC5 0 0 442 461 1 1
    FADD OPTN 0 0 141 159 1 2
    FADD MAP3K5 0 900 536 951 1 1
    FADD MCL1 0 0 602 612 1 2
    FADD SIRT1 0 0 202 202 1 2
    FADD MAPK8IP3 0 0 126 269 1 1
    FADD CTSB 0 0 295 295 1 2
    FADD SPI1 0 0 209 209 1 1
    FADD LMNB1 0 0 195 225 1 1
    FADD NOX1 0 0 307 307 1 1
    FADD IRF1 0 0 323 348 1 1
    FADD MIB1 0 0 486 494 1 1
    FADD PTPN1 0 0 82 237 1 1
    FADD XBP1 0 0 253 252 1 2
    FADD TP63 0 0 215 215 1 2
    FADD HIPK2 0 0 133 202 1 1
    FADD YAP1 0 0 180 179 1 1
    FADD STAT2 0 0 188 199 1 1
    FADD KCMF1 0 0 0 154 1 1
    FADD EDAR 270 0 307 472 1 1
    FADD TLR8 0 0 247 258 1 1
    FADD PREP 192 0 0 211 1 1
    FADD ATG5 270 0 989 994 1 2
    FADD LSM11 0 0 325 325 1 1
    FADD SPHK1 0 0 103 158 1 2
    FADD HMOX2 0 0 236 275 1 1
    FADD ADAM17 0 0 232 231 1 1
    FADD NFKBIB 0 0 193 315 1 1
    FADD MAP1LC3B 0 0 278 366 1 2
    FADD DFFB 0 0 505 518 1 1
    FADD ISG15 0 0 167 248 1 1
    FADD UBC 0 0 67 177 1 1
    FADD ANXA6 0 0 0 189 1 1
    FADD TERT 0 0 218 223 1 1
    FADD HSPB2 0 0 323 333 1 1
    FADD HSPB1 0 0 310 337 1 1
    FADD VAV1 0 0 141 226 1 1
    FADD MST1R 0 0 70 187 1 1
    FADD ATG10 0 0 193 198 1 2
    FADD AKT3 0 0 126 158 1 1
    FADD DEDD2 0 0 551 560 1 1
    FADD IKBKG 681 900 696 990 1 1
    FADD MAP4K4 0 900 73 903 1 1
    FADD PDCD2L 0 0 63 267 1 1
    FADD FN1 0 0 205 205 1 1
    FADD NUMA1 0 0 115 156 1 1
    FADD PLK3 0 0 134 193 1 1
    FADD ULK1 0 0 220 255 1 2
    FADD RIPK4 0 0 136 183 1 1
    FADD PRKCA 0 0 166 165 1 1
    FADD MAP3K12 0 0 219 219 1 1
    FADD RPS6KA1 0 0 193 212 1 1
    FADD BCAP31 0 0 193 210 1 1
    FADD PRDX4 128 0 0 173 1 1
    FADD FGF2 0 0 171 171 1 1
    FADD DRAM1 0 0 165 179 1 2
    FADD RELB 0 0 364 379 1 2
    FADD SDF2L1 0 0 0 275 1 1
    FADD MMP8 0 0 60 158 1 1
    FADD ADM2 0 0 0 187 1 1
    FADD BCL2A1 0 0 421 420 1 1
    FADD IFI16 0 0 202 202 1 1
    FADD BMF 0 0 390 394 1 1
    FADD TNFSF14 0 0 135 154 1 1
    FADD CD70 0 0 180 181 1 1
    FADD MAP3K14 0 900 212 921 1 1
    FADD CCND2 0 0 138 173 1 1
    FADD IFNAR1 0 0 263 263 1 1
    FADD ATG4B 0 0 147 173 1 2
    FADD NFKB2 0 0 378 387 1 1
    FADD TNFAIP3 677 900 320 976 1 1
    FADD IGF1 0 0 233 232 1 1
    FADD IRF7 270 0 410 572 1 1
    FADD MAPK1 0 0 425 425 1 2
    FADD UVRAG 0 0 174 210 1 2
    FADD BTK 189 900 416 950 1 1
    FADD FHIT 0 0 448 448 1 1
    FADD SOCS1 0 0 261 296 1 1
    FADD RNF41 192 0 74 233 1 1
    FADD GADD45A 0 0 232 231 1 1
    FADD ATF3 0 0 193 193 1 1
    FADD ITK 0 0 74 154 1 1
    FADD IL7 0 0 159 158 1 1
    FADD CD44 0 0 211 211 1 1
    FADD FAIM3 0 0 414 414 1 1
    FADD CASP2 0 900 602 963 1 1
    FADD PIK3R2 0 0 90 178 1 1
    FADD HIPK3 462 0 795 888 1 1
    FADD DUSP26 0 0 293 341 1 1
    FADD MMP3 0 0 136 170 1 1
    FADD FAIM 0 0 229 228 1 1
    FADD SDK2 192 0 0 192 1 1
    FADD TANK 192 0 426 516 1 1
    FADD TNF 270 900 923 996 1 1
    FADD SEMA4D 0 0 0 260 1 1
    FADD C22orf29 0 0 517 517 1 1
    FADD XDH 0 0 310 309 1 1
    FADD TIRAP 0 800 361 888 1 1
    FADD SLC7A11 128 0 66 150 1 1
    FADD RNF135 0 600 114 630 1 1
    FADD STIP1 0 0 0 153 1 1
    FADD PPP1R15A 0 0 206 206 1 2
    FADD SMPD2 0 0 180 209 1 1
    FADD IGBP1 0 0 81 302 1 1
    FADD ITCH 0 0 252 252 1 1
    FADD DDX3X 0 0 137 156 1 1
    FADD MMP7 0 0 170 169 1 1
    FADD NAIP 0 0 341 386 1 1
    FADD BAG4 0 900 327 929 1 1
    FADD ATF7 0 0 167 173 1 1
    FADD RNASEL 0 0 193 276 1 1
    FADD ANXA7 0 0 0 192 1 2
    FADD PTPN2 0 0 66 165 1 2
    FADD BAK1 0 0 459 509 1 2
    FADD FEM1B 0 0 398 407 1 1
    FADD PRKRIR 296 0 72 318 1 1
    FADD BCL2 0 0 218 242 1 2
    FADD CARD18 0 0 328 393 1 1
    FADD DFFA 0 0 468 479 1 1
    FADD CTLA4 0 0 269 269 1 1
    FADD PSMA7 0 0 88 151 1 1
    FADD ANK2 0 0 0 157 1 1
    FADD UBB 0 0 0 154 1 1
    FADD CAT 0 0 274 274 1 1
    FADD HRK 0 0 344 343 1 1
    FADD CCNE1 0 0 143 190 1 1
    FADD CANX 0 0 150 178 1 2
    FADD TXN 0 0 230 241 1 1
    FADD MCM7 0 0 61 223 1 1
    FADD ENSG00000258973 0 0 0 325 1 1
    FADD NTRK1 0 0 155 179 1 1
    FADD IFT43 0 0 467 467 1 1
    FADD IRS1 0 0 134 157 1 1
    FADD CBL 0 0 171 174 1 1
    FADD EFS 0 0 207 207 1 1
    FADD RPS6KB1 0 0 229 228 1 2
    FADD BAD 0 0 370 391 1 1
    FADD CDK1 0 0 272 293 1 1
    FADD PGR 0 0 130 220 1 1
    FADD CD274 0 0 155 154 1 1
    FADD CCND1 0 0 464 496 1 1
    FADD TNFRSF10D 0 0 716 875 1 1
    FADD ACOT7 0 0 490 489 1 1
    FADD NOS3 0 0 150 205 1 1
    FADD ULK3 192 0 0 278 1 2
    FADD BLNK 0 0 90 171 1 1
    FADD IRAK2 0 0 735 742 1 1
    FADD ANXA2 0 0 54 179 1 1
    FADD PDLIM7 0 0 123 165 1 1
    FADD BCL2L2 0 0 459 459 1 1
    FADD CD19 0 0 181 181 1 1
    FADD UBE2I 111 0 90 185 1 1
    FADD SRC 0 0 371 404 1 1
    FADD DAP3 462 900 931 996 1 1
    FADD TUBA1C 0 0 0 225 1 1
    FADD RAG1 0 0 161 161 1 1
    FADD CDC42 0 0 167 179 1 1
    FADD ATG4C 0 0 98 167 1 2
    FADD C1QBP 0 0 108 153 1 1
    FADD IL25 0 0 441 441 1 1
    FADD DHFRL1 0 0 0 384 1 1
    FADD TNFSF11 0 0 171 171 1 1
    FADD USP2 0 900 103 906 1 1
    FADD FOXO3 0 0 286 286 1 2
    FADD EIF2AK3 0 0 325 339 1 2
    FADD STAT6 0 0 150 199 1 1
    FADD TP53INP1 0 0 129 162 1 2
    FADD TNFSF12 0 900 422 939 1 1
    FADD CDKN3 0 0 154 178 1 1
    FADD TUBB8 0 0 0 155 1 1
    FADD TLR3 270 600 586 870 1 1
    FADD BNIP1 0 0 126 154 1 2
    FADD BIRC6 0 0 284 362 1 1
    FADD ATG3 0 0 370 383 1 2
    FADD LGALS3 0 0 108 163 1 1
    FADD COASY 0 0 161 195 1 1
    FADD SKP1 0 0 120 157 1 1
    FADD EIF2S1 0 0 294 324 1 2
    FADD JAK1 0 0 235 257 1 1
    FADD CLDN7 0 0 438 438 1 1
    FADD KDR 0 0 134 188 1 2
    FADD MDH2 0 0 142 165 1 1
    FADD FOXP3 0 0 181 181 1 1
    FADD RGS19 0 0 106 192 1 2
    FADD HMOX1 0 0 217 253 1 2
    FADD TBK1 0 0 556 571 1 2
    FADD TCHP 0 0 281 281 1 1
    FADD TICAM2 0 600 229 679 1 1
    FADD RHOH 0 0 46 191 1 1
    FADD RB1 0 0 193 193 1 2
    FADD PIP4K2B 0 0 327 327 1 1
    FADD RIPK3 870 900 988 999 1 1
    FADD MRPS2 0 0 0 182 1 1
    FADD IFIT1 0 0 154 153 1 1
    FADD ANO4 0 0 324 323 1 1
    FADD CDKN1B 0 0 247 248 1 2
    FADD PRKCD 0 0 205 205 1 2
    FADD BNIP3L 0 0 243 242 1 2
    FADD GLUL 0 0 113 163 1 1
    FADD TSC2 0 0 160 166 1 2
    FADD STAT5B 0 0 195 195 1 1
    FADD TGFB1 0 0 139 166 1 1
    FADD VDAC1 0 0 157 156 1 2
    FADD CARD14 0 0 45 263 1 1
    FADD LAMB3 0 0 54 222 1 1
    FADD CARD8 0 0 125 232 1 1
    FADD FAS 981 900 989 999 1 2
    FADD SUMO1 0 0 181 198 1 1
    FADD INPP5D 0 0 170 169 1 1
    FADD CD4 0 0 407 407 1 1
    FADD VCAM1 0 0 151 150 1 1
    FADD AKT1 0 0 561 591 1 2
    FADD PPARG 0 0 433 433 1 1
    FADD UBE3A 0 0 235 269 1 1
    FADD LY96 0 600 188 667 1 1
    FADD CSF2 0 0 282 282 1 1
    FADD UBR4 0 0 45 185 1 1
    FADD KCNJ6 0 0 165 165 1 1
    FADD E2F4 189 0 87 257 1 1
    FADD ING1 0 0 125 179 1 1
    FADD PPP2R4 0 0 218 218 1 1
    FADD TMEM74 0 0 144 197 1 2
    FADD EIF2B2 0 0 56 155 1 1
    FADD XIAP 0 0 690 770 1 1
    FADD PSMD5 0 0 117 153 1 1
    FADD FGFR1 0 0 160 159 1 1
    FADD SDF2 0 0 0 178 1 1
    FADD IKBKB 0 900 518 951 1 1
    FADD NLRC4 270 0 390 536 1 2
    FADD CLDN1 0 0 67 165 1 1
    FADD ATF6 0 0 263 269 1 2
    FADD PANX1 0 0 150 170 1 1
    FADD FGF3 0 0 520 520 1 1
    FADD NUPL2 128 0 0 151 1 1
    FADD HSP90AB1 0 0 108 258 1 2
    FADD ANK3 213 0 54 282 1 1
    FADD BIRC8 0 0 280 456 1 1
    FADD KRT18 0 0 184 207 1 1
    FADD EIF4EBP1 0 0 181 211 1 1
    FADD CYLD 0 900 826 981 1 1
    FADD CXCL10 0 0 227 226 1 1
    FADD MALT1 0 0 335 335 1 1
    FADD GPT 0 0 166 165 1 1
    FADD WWOX 0 0 125 159 1 1
    FADD EHD1 682 0 0 690 1 1
    FADD C9orf89 0 0 140 247 1 1
    FADD IL24 0 0 161 161 1 2
    FADD LTV1 0 0 0 188 1 1
    FADD BIRC5 0 0 261 323 1 2
    FADD PPP3CA 0 0 108 151 1 1
    FADD ERBB2 0 0 319 319 1 2
    FADD NGF 0 0 210 210 1 1
    FADD CD34 0 0 167 167 1 1
    FADD IRF3 189 0 517 636 1 1
    FADD NLRP7 0 0 139 174 1 1
    FADD BBC3 0 0 342 361 1 1
    FADD CARD6 0 0 243 319 1 1
    FADD TNFSF8 0 0 235 235 1 1
    FADD PRKRA 0 0 150 214 1 1
    FADD AIFM1 0 0 224 355 1 1
    FADD PYCARD 0 0 341 355 1 1
    FADD MAP3K1 0 900 369 934 1 1
    FADD PAFAH1B2 0 0 55 157 1 1
    FADD TLR9 0 0 339 354 1 1
    FADD CALR 0 0 181 208 1 1
    FADD BIK 0 0 325 325 1 1
    FADD BTG1 234 0 0 234 1 1
    FADD CD8A 0 0 394 394 1 1
    FADD EIF2AK2 0 800 231 864 1 2
    FADD CLPX 0 0 218 245 1 1
    FADD TNFRSF13C 0 0 189 189 1 1
    FADD MMP2 0 0 234 234 1 1
    FADD RIPK2 0 900 391 941 1 1
    FADD TNFRSF8 0 0 278 278 1 1
    FADD SPOP 454 0 90 488 1 1
    FADD LCK 0 0 236 273 1 1
    FADD VCP 0 0 305 338 1 2
    FADD NFKBIL1 0 0 94 167 1 1
    FADD YWHAE 0 0 93 158 1 1
    FADD FYN 0 0 134 177 1 1
    FADD TICAM1 0 900 422 942 1 1
    FADD NFKBIE 0 0 163 231 1 1
    FADD GRB2 0 0 210 210 1 1
    FADD PELI3 0 0 0 179 1 1
    FADD CSNK1A1 476 0 438 693 1 1
    FADD CDKL3 0 0 47 253 1 1
    FADD LTA 0 0 241 570 1 1
    FADD SOD1 0 0 486 500 1 1
    FADD USP4 0 900 73 915 1 1
    FADD CDC25C 0 0 181 197 1 1
    FADD IL37 483 0 0 483 1 1
    FADD SERPINA1 0 0 74 173 1 2
    FADD ENSG00000173366 0 0 335 350 1 1
    FADD GZMA 0 0 140 174 1 1
    FADD BCL2L11 0 0 595 612 1 1
    FADD ARL14EPL 0 0 113 153 1 1
    FADD TNIP3 0 0 95 185 1 1
    FADD TMEM173 0 0 181 181 1 1
    FADD DAPK1 728 0 544 870 1 2
    FADD TYK2 0 0 170 244 1 1
    FADD COPE 0 0 0 157 1 1
    FADD ITPR3 0 0 143 162 1 1
    FADD JUN 0 0 556 556 1 1
    FADD CCNA2 0 0 229 251 1 1
    FADD DEDD 486 0 541 756 1 1
    FADD NOS1 0 0 626 626 1 1
    FADD CASP1 0 0 696 734 1 2
    FADD TK1 0 0 53 152 1 1
    FADD CHEK1 0 0 247 246 1 1
    FADD DNTT 0 0 405 421 1 1
    FADD CD27 0 0 193 193 1 1
    FADD JAK3 0 0 113 225 1 1
    FADD PIK3CG 0 0 139 177 1 1
    FADD MAP2K3 0 0 213 249 1 1
    FADD BOK 0 0 248 324 1 2
    FADD ULK2 0 0 108 160 1 2
    FADD HSPA1A 0 0 123 183 1 1
    FADD CAV1 0 0 339 339 1 1
    FADD TNFSF10 897 900 879 998 1 2
    FADD CERKL 0 0 0 171 1 1
    FADD AK2 0 0 979 981 1 1
    FADD ACTB 0 0 507 538 1 1
    FADD ATG13 0 0 210 210 1 2
    FADD INS 0 0 255 254 1 1
    FADD MSN 287 0 105 334 1 1
    FADD NEFH 260 0 0 260 1 1
    FADD RFK 0 0 310 309 1 1
    FADD NLRX1 0 0 206 228 1 1
    FADD STUB1 270 0 161 377 1 2
    FADD DNMT1 0 0 164 163 1 1
    FADD C1S 0 0 102 195 1 1
    FADD CD40 0 0 392 392 1 1
    FADD ARHGDIA 287 0 96 384 1 1
    FADD CTTN 0 0 358 389 1 1
    FADD MAPK3 0 0 496 496 1 2
    FADD KEAP1 0 0 134 151 1 2
    FADD MMP9 0 0 294 294 1 1
    FADD PROM1 0 0 126 180 1 1
    FADD ANXA4 0 0 0 189 1 1
    FADD TRAM1 0 0 0 209 1 1
    FADD BNIP3 0 0 310 309 1 2
    FADD SQSTM1 270 0 258 435 1 2
    FADD IL3 0 0 167 219 1 1
    FADD LTB 0 0 113 161 1 1
    FADD HSP90AA1 0 0 371 380 1 2
    FADD HPGDS 0 0 201 201 1 1
    FADD HTRA2 0 0 468 491 1 1
    FADD ATF2 0 0 143 196 1 1
    FADD TP73 0 0 193 210 1 2
    FADD COX4I1 0 0 202 202 1 1
    FADD SMDT1 0 0 674 674 1 1
    FADD BCL10 0 0 414 424 1 1
    FADD MLKL 0 0 802 841 1 1
    FADD PTPRC 0 0 261 262 1 1
    FADD PROSC 0 0 137 174 1 1
    FADD ICAM1 0 0 241 240 1 1
    FADD UNC93B1 0 0 124 167 1 1
    FADD GABARAPL1 0 0 233 296 1 2
    FADD CDKN1A 0 0 334 334 1 2
    FADD EBAG9 0 0 160 159 1 1
    FADD BCLAF1 0 0 134 152 1 1
    FADD TNFRSF14 0 0 165 165 1 1
    FADD HSPA8 0 0 167 202 1 2
    FADD BID 676 900 600 986 1 1
    FADD PARP1 0 0 372 396 1 2
    FADD RHOA 676 0 167 718 1 1
    FADD AR 0 0 195 195 1 1
    FADD EIF4G1 0 0 94 214 1 2
    FADD STX1A 0 0 54 200 1 1
    FADD TLR5 0 0 218 230 1 1
    FADD RCN2 0 0 150 183 1 1
    FADD AURKA 0 0 472 496 1 2
    FADD TIMP1 0 0 172 171 1 1
    FADD UBE2N 0 0 241 271 1 1
    FADD FGF4 0 0 235 235 1 1
    FADD BAX 0 0 470 494 1 2
    FADD GMEB1 0 0 51 210 1 1
    FADD AIM2 0 0 336 336 1 1
    FADD DDX58 0 600 553 813 1 1
    FADD CDK6 0 0 261 277 1 1
    FADD NEFL 0 0 296 296 1 1
    FADD MAPKAPK2 0 0 108 190 1 1
    FADD BCL2L10 0 0 290 290 1 1
    FADD CDH1 0 0 242 241 1 1
    FADD PRKCZ 270 0 171 387 1 1
    FADD DDX55 0 0 0 190 1 1
    FADD MB21D1 0 0 170 174 1 1
    FADD MFGE8 0 0 142 171 1 1
    FADD TRIM21 270 0 442 586 1 1
    FADD BCL2L13 0 0 180 266 1 1
    FADD RNF31 0 0 591 596 1 1
    FADD ATG16L2 0 0 134 281 1 2
    FADD ZYX 0 0 49 214 1 1
    FADD ABCA1 270 0 49 276 1 1
    FADD TRADD 880 900 989 999 1 1
    FADD IL1A 0 0 310 309 1 1
    FADD TFPI 0 0 58 315 1 1
    FADD CCL4 0 0 153 153 1 1
    FADD H2AFX 0 0 174 223 1 1
    FADD MAVS 270 600 942 983 1 1
    FADD CCL2 0 0 293 293 1 2
    FADD LRRFIP1 0 0 150 169 1 1
    FADD CASP8 992 900 990 999 1 2
    FADD ALB 0 0 320 362 1 1
    FADD CARD17 0 0 123 234 1 1
    FADD MYEOV 0 0 265 265 1 1
    FADD OTULIN 0 0 265 273 1 1
    FADD CD276 0 0 134 174 1 1
    FADD CASP7 0 900 632 966 1 1
    FADD CUL1 0 0 628 628 1 1
    FADD CSNK1D 192 0 0 192 1 1
    FADD XPO4 0 0 0 152 1 1
    FADD ANXA3 0 0 0 189 1 1
    FADD IL4 0 0 254 254 1 1
    FADD MSRB2 0 0 436 436 1 1
    FADD EP300 0 0 209 209 1 1
    FADD MADD 0 900 113 907 1 1
    FADD TNFRSF10A 870 900 988 999 1 1
    FADD DAG1 0 0 54 199 1 1
    FADD SMAD3 0 0 150 169 1 1
    FADD BIRC3 0 900 606 969 1 1
    FADD ANXA8 0 0 322 321 1 1
    FADD MAPK9 0 0 293 296 1 2
    FADD TLR7 0 0 323 333 1 1
    FADD DHX36 0 0 103 168 1 1
    FADD RPS6KA3 0 0 171 196 1 1
    FADD GADD45B 0 0 185 201 1 1
    FADD CHEK2 0 0 235 251 1 1
    FADD CYCS 0 0 753 760 1 1
    FADD CLSPN 0 0 219 235 1 1
    FADD ANXA13 0 0 0 248 1 1
    FADD TRAF6 0 900 661 965 1 2
    FADD CASP9 0 0 801 869 1 1
    FADD ITPR1 0 0 160 159 1 2
    FADD ETS1 0 0 96 161 1 1
    FADD BFAR 0 0 150 188 1 1
    FADD PCSK1 0 0 604 611 1 1
    FADD PELI1 0 0 206 355 1 1
    FADD EGF 0 0 310 309 1 1
    FADD PAWR 0 0 322 325 1 1
    FADD IL17A 0 0 218 218 1 1
    FADD ENSG00000266953 0 0 0 230 1 1
    FADD DICER1 0 0 171 175 1 1
    FADD PIK3R1 0 0 161 213 1 1
    FADD CLTC 0 900 49 903 1 1
    FADD HSPA4 0 0 324 347 1 1
    FADD RAD17 0 0 150 181 1 1
    FADD PPARA 0 0 150 186 1 1
    FADD DDX1 0 0 68 160 1 1
    FADD CHAT 0 0 307 307 1 1
    FADD HSP90B1 0 0 170 169 1 1
    FADD TRPC6 209 0 0 209 1 1
    FADD HSPB3 0 0 315 315 1 1
    FADD XPO5 270 0 391 539 1 1
    FADD DIABLO 0 0 710 743 1 1
    FADD PXN 0 0 102 195 1 1
    FADD SPATA2 0 0 213 213 1 1
    FADD IFIH1 0 600 429 763 1 1
    FADD STAB2 0 0 103 159 1 1
    FADD GPX4 0 0 171 189 1 1
    FADD DAPK3 0 0 101 152 1 2
    FADD CISH 0 0 170 169 1 1
    FADD GLUD1 0 0 184 183 1 1
    FADD PRF1 0 0 273 273 1 1
    FADD P2RX7 0 0 151 150 1 1
    FADD GNPTAB 0 0 376 376 1 1
    FADD MAPK8 287 0 468 616 1 2
    FADD PTK2 0 0 216 216 1 1
    FADD SHANK2 0 0 167 180 1 1
    FADD MAP2K4 0 900 296 928 1 1
    FADD MAU2 0 0 113 176 1 1
    FADD S1PR2 192 0 0 192 1 1
    FADD CIDEB 0 0 150 183 1 1
    FADD PPP3CC 0 0 113 156 1 1
    FADD SMAD4 0 0 202 216 1 1
    FADD TNFRSF12A 0 0 321 359 1 1
    FADD FASTK 0 0 149 207 1 1
    FADD NOL3 481 0 327 666 1 1
    FADD PARK7 270 0 95 333 1 1
    FADD UBD 0 0 95 155 1 1
    FADD ANO1 0 0 442 442 1 1
    FADD TNFRSF13B 0 0 166 167 1 1
    FADD CASP10 874 900 986 999 1 1
    FADD TLR1 0 0 267 294 1 1
    FADD PGAM5 0 0 501 530 1 1
    FADD PSMB3 0 0 0 152 1 1
    FADD RB1CC1 0 0 205 205 1 2
    FADD DHX58 0 0 325 325 1 1
    FADD UBBP4 0 0 0 154 1 1
    FADD MFF 0 0 161 165 1 1
    FADD PPIF 0 0 305 330 1 1
    FADD CARD10 0 0 147 236 1 1
    FADD MAP3K8 0 0 193 198 1 1
    FADD MAP2K1 0 0 283 286 1 1
    FADD NFX1 0 0 136 226 1 1
    FADD CD80 0 0 181 181 1 1
    FADD NLRP12 0 0 161 161 1 1
    FADD BRCA1 0 0 193 193 1 1
    FADD RBCK1 0 0 400 400 1 1
    FADD RALGDS 270 0 0 303 1 1
    FADD IL18 0 0 392 392 1 1
    FADD ILK 0 0 97 341 1 1
    FADD IFNA1 0 0 391 390 1 1
    FADD IL1R1 0 0 305 305 1 1
    FADD IL15 0 0 205 205 1 1
    FADD IRGM 0 0 171 171 1 2
    FADD MYC 0 0 455 473 1 2
    FADD RNF125 0 0 124 257 1 1
    FADD TNFRSF6B 0 0 323 323 1 1
    FADD KIF2C 192 0 0 216 1 1
    FADD TAB2 0 0 503 506 1 1
    FADD ADRBK2 0 0 0 175 1 1
    FADD IGF1R 0 0 263 284 1 1
    FADD APOA1BP 683 0 0 688 1 1
    FADD USP15 0 0 57 270 1 1
    FADD SEMA6A 0 0 435 435 1 1
    FADD CASP8AP2 270 0 490 612 1 1
    FADD MEFV 0 0 404 404 1 2
    FADD TMBIM6 0 0 193 332 1 1
    FADD MX1 0 0 181 181 1 1
    FADD TRAF2 462 900 882 994 1 1
    FADD TAB1 74 0 391 419 1 1
    FADD ROR1 192 0 0 215 1 1
    FADD TOP1 0 0 167 167 1 1
    FADD PIK3CA 0 0 260 260 1 2
    FADD HDAC6 0 0 123 161 1 2
    FADD APAF1 0 0 773 794 1 1
    FADD ORAOV1 0 0 506 578 1 1
    FADD RNF126 0 0 0 163 1 1
    FADD JAK2 0 0 194 227 1 1
    FADD RALBP1 213 0 0 213 1 1
    FADD CLU 0 0 143 168 1 2
    FADD MED23 0 0 46 218 1 1
    FADD PIN1 270 0 46 288 1 1
    FADD MKRN1 270 0 213 400 1 1
    FADD PRKAR2A 0 0 113 155 1 1
    FADD ERN1 0 0 280 301 1 2
    FADD XRCC6 0 0 135 152 1 1
    FADD SPTLC1 0 0 54 174 1 1
    FADD SIVA1 0 0 398 398 1 1
    FADD SNX12 0 0 0 183 1 1
    FADD STAT3 0 0 391 390 1 2
    FADD MKKS 0 0 114 207 1 1
    FADD BNIP2 0 0 203 212 1 1
    FADD MDM2 0 0 370 370 1 1
    FADD TP53 0 0 633 646 1 2
    FADD IRF9 0 0 182 181 1 1
    FADD GART 0 0 44 154 1 1
    FADD EGFR 0 0 393 392 1 1
    FADD CFLAR 892 900 989 999 1 1
    FADD CCS 0 0 291 294 1 1
    FADD CDK4 0 0 324 342 1 1
    FADD MAP3K13 0 0 258 258 1 1
    FADD TNFRSF4 0 0 163 163 1 1
    FADD MYD88 631 800 974 998 1 1
    FADD SARM1 0 0 142 220 1 1
    FADD NEDD8 0 0 103 166 1 1
    FADD LAMP1 0 0 124 159 1 2
    FADD CARD9 0 0 181 237 1 1
    FADD TRAF1 0 900 523 953 1 1
    FADD IRAK1 213 0 613 707 1 1
    FADD FAM63A 0 0 0 154 1 1
    FADD CSF3 0 0 181 181 1 1
    FADD RAF1 0 0 182 233 1 2
    FADD LMNA 0 0 217 253 1 1
    FADD ZBP1 0 0 362 365 1 1
    FADD LCP2 0 0 113 209 1 1
    FADD LAMA4 0 0 0 248 1 1
    FADD TNFRSF11B 0 0 359 368 1 1
    FADD CRADD 0 900 715 970 1 1
    FADD DDIT3 0 0 322 321 1 2
    FADD MAP3K7 0 0 413 437 1 1
    FADD GUK1 0 0 0 154 1 1
    FADD MMP1 0 0 149 180 1 1
    FADD PTPN13 213 900 390 947 1 1
    FADD NOTCH1 0 0 225 236 1 1
    FADD CD40LG 0 0 323 323 1 1
    FADD PIDD1 486 0 620 805 1 1
    FADD USP21 0 900 53 902 1 1
    FADD TRAF4 0 0 335 355 1 1
    FADD CXCR4 0 0 167 167 1 2
    FADD RELL2 0 0 103 240 1 1
    FADD POTEF 0 0 134 172 1 1
    FADD E2F2 0 0 112 167 1 1
    FADD DDX21 0 0 72 165 1 1
    FADD NLRP1 0 0 334 334 1 1
    FADD MTOR 0 0 321 321 1 2
    FADD PDCD5 0 0 81 150 1 1
    FADD IL6 0 0 459 459 1 1
    FADD TNFRSF19 0 0 120 152 1 1
    FADD DCXR 0 0 310 309 1 1
    FADD NACA 486 0 0 500 1 1
    FADD PIK3C3 0 0 294 322 1 2
    FADD TNFRSF1A 751 900 989 999 1 1
    FADD GZMB 0 0 261 261 1 1
    FADD PLEK 0 0 315 315 1 1
    FADD KCNMA1 0 0 0 181 1 1
    FADD OCLN 0 0 719 721 1 1
    FADD TFPI2 0 0 48 380 1 1
    FADD BCL2L2-PABPN1 0 0 427 426 1 1
    FADD ENDOG 0 0 464 497 1 1
    FADD STAT1 213 900 527 959 1 1
    FADD SP1 0 0 167 171 1 1
    FADD IL1B 0 0 563 566 1 1
    FADD FAT1 0 0 242 241 1 1
    FADD RAB5A 0 0 221 231 1 2
    FADD TRPM7 0 0 297 297 1 1
    FADD TRAF5 0 0 528 557 1 1
    FADD PYGL 0 0 169 169 1 1
    FADD HIF1A 0 0 320 319 1 2
    FADD IL6R 0 0 150 169 1 1
    FADD CXCL8 0 0 391 390 1 1
    FADD KCNU1 0 0 0 159 1 1
    FADD EGR1 0 0 171 171 1 1
    FADD APP 0 0 144 154 1 1
    FADD HRAS 0 0 322 369 1 1
    FADD MAP1LC3A 0 0 150 351 1 2
    FADD CTNNB1 0 0 324 338 1 1
    FADD CDK2 0 0 294 322 1 1
    FADD TNFRSF1B 0 0 451 451 1 1
    FADD XPO1 0 0 90 158 1 1
    FADD ZCCHC12 173 0 0 173 1 1
    FADD IKBKE 0 0 283 427 1 1
    FADD ZAP70 0 0 150 264 1 1
    FADD TLR10 0 0 112 217 1 1
    FADD CLEC7A 0 0 167 167 1 1
    FADD CASP6 0 0 602 658 1 1
    FADD TAB3 0 0 369 369 1 2
    FADD STAT4 0 0 70 169 1 1
    FADD BUB1 0 0 453 467 1 1
    FADD TRIM25 0 600 210 680 1 1
    FADD PIK3R4 0 0 170 241 1 2
    FADD BCL2L1 0 0 710 746 1 2
    FADD ENSG00000026036 0 0 323 323 1 1
    FADD RELA 0 0 459 481 1 1
    FADD CARM1 0 0 0 208 1 1
    FADD NFKB1 0 0 394 443 1 1
    FADD C1R 0 0 90 189 1 1
    FADD TNFRSF25 0 900 802 980 1 1
    FADD NDNF 192 0 0 192 1 1
    FADD GAPDH 0 0 460 483 1 2
    FADD SMAD2 0 0 170 169 1 1
    FADD CCDC50 192 0 0 192 1 1
    FADD TLR4 0 600 504 796 1 1
    FADD VWA7 0 0 57 202 1 1
    FADD ABL1 0 0 189 244 1 1
    FADD MAP2K7 0 900 325 929 1 1
    FADD PELI2 0 0 0 221 1 1
    FADD CD14 0 600 0 605 1 1
    FADD GABARAPL2 0 0 220 285 1 2
    FADD TNFSF15 0 0 270 294 1 1
    FADD RAP1A 270 0 0 270 1 1
    FADD UBE2V2 0 0 0 184 1 1
    FADD JAG2 0 0 54 199 1 1
    FADD PSMA1 0 0 0 213 1 1
    FADD TPCN2 0 0 181 181 1 1
    FADD PSMB1 0 0 58 163 1 1
    FADD CREBBP 0 0 127 154 1 1
    FADD PFKL 0 0 167 187 1 1
    FADD PPFIA1 0 0 416 463 1 1
    FADD KCNJ11 0 0 202 202 1 1
    FADD CCL5 0 0 233 232 1 1
    FADD GSDMD 0 0 350 349 1 1
    FADD CREB1 0 0 245 256 1 1
    FADD IFNG 0 0 265 315 1 2
    FADD NIT1 0 0 170 169 1 1
    FADD BIRC2 0 900 798 982 1 1
    FADD KHDRBS1 270 0 113 398 1 1
    FADD GZMM 0 0 193 193 1 1
    FADD PERP 0 0 123 227 1 1
    FADD HSPD1 97 0 136 186 1 1
    FADD MGMT 0 0 141 159 1 1
    FADD CCNB1 0 0 263 294 1 1
    FADD ANXA5 0 0 595 625 1 1
    FADD PLK1 270 0 816 862 1 1
    FADD GSDMA 0 0 233 232 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0089720 Molecular Function caspase binding enables IBA
    GO:0089720 Molecular Function caspase binding enables IDA
    GO:0089720 Molecular Function caspase binding enables IPI
    GO:0035877 Molecular Function death effector domain binding enables IPI
    GO:0005123 Molecular Function death receptor binding enables IBA
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0002020 Molecular Function protease binding enables IPI
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0044877 Molecular Function protein-containing complex binding enables IEA
    GO:0030674 Molecular Function protein-macromolecule adaptor activity enables IDA
    GO:0033612 Molecular Function receptor serine/threonine kinase binding enables IEA
    GO:0035591 Molecular Function signaling adaptor activity enables IEA
    GO:0005164 Molecular Function tumor necrosis factor receptor binding enables IEA
    GO:0032813 Molecular Function tumor necrosis factor receptor superfamily binding enables IPI
    GO:0033077 Biological Process T cell differentiation in thymus involved_in ISS
    GO:0043029 Biological Process T cell homeostasis involved_in ISS
    GO:0036462 Biological Process TRAIL-activated apoptotic signaling pathway involved_in IDA
    GO:0006915 Biological Process apoptotic process involved_in IMP
    GO:0097190 Biological Process apoptotic signaling pathway involved_in IDA
    GO:0048148 Biological Process behavioral response to cocaine involved_in IEA
    GO:0071260 Biological Process cellular response to mechanical stimulus involved_in IEP
    GO:0071550 Biological Process death-inducing signaling complex assembly involved_in IDA
    GO:0051607 Biological Process defense response to virus involved_in IMP
    GO:0097191 Biological Process extrinsic apoptotic signaling pathway involved_in IBA
    GO:0097191 Biological Process extrinsic apoptotic signaling pathway involved_in IDA
    GO:0097191 Biological Process extrinsic apoptotic signaling pathway involved_in IMP
    GO:0097191 Biological Process extrinsic apoptotic signaling pathway involved_in TAS
    GO:0097192 Biological Process extrinsic apoptotic signaling pathway in absence of ligand involved_in IEA
    GO:0008625 Biological Process extrinsic apoptotic signaling pathway via death domain receptors involved_in IDA
    GO:0045087 Biological Process innate immune response involved_in IEA
    GO:0001822 Biological Process kidney development involved_in IEA
    GO:0048535 Biological Process lymph node development involved_in ISS
    GO:0097049 Biological Process motor neuron apoptotic process involved_in IEA
    GO:0097527 Biological Process necroptotic signaling pathway involved_in IMP
    GO:0070236 Biological Process negative regulation of activation-induced cell death of T cells involved_in ISS
    GO:0060546 Biological Process negative regulation of necroptotic process involved_in IEA
    GO:2000454 Biological Process positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation involved_in ISS
    GO:0001916 Biological Process positive regulation of T cell mediated cytotoxicity involved_in ISS
    GO:0042104 Biological Process positive regulation of activated T cell proliferation involved_in ISS
    GO:0002821 Biological Process positive regulation of adaptive immune response involved_in ISS
    GO:0043065 Biological Process positive regulation of apoptotic process involved_in IDA
    GO:0043065 Biological Process positive regulation of apoptotic process involved_in IMP
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IEP
    GO:1900119 Biological Process positive regulation of execution phase of apoptosis involved_in IEA
    GO:2001238 Biological Process positive regulation of extrinsic apoptotic signaling pathway involved_in IMP
    GO:0045089 Biological Process positive regulation of innate immune response involved_in IBA
    GO:0032757 Biological Process positive regulation of interleukin-8 production involved_in IDA
    GO:0045651 Biological Process positive regulation of macrophage differentiation involved_in IMP
    GO:0045862 Biological Process positive regulation of proteolysis involved_in IDA
    GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
    GO:0032760 Biological Process positive regulation of tumor necrosis factor production involved_in IDA
    GO:0060340 Biological Process positive regulation of type I interferon-mediated signaling pathway involved_in IMP
    GO:0032729 Biological Process positive regulation of type II interferon production involved_in ISS
    GO:0048536 Biological Process spleen development involved_in ISS
    GO:0048538 Biological Process thymus development involved_in ISS
    GO:0031265 Cellular Component CD95 death-inducing signaling complex part_of IBA
    GO:0031265 Cellular Component CD95 death-inducing signaling complex part_of IDA
    GO:0044297 Cellular Component cell body located_in IEA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0009898 Cellular Component cytoplasmic side of plasma membrane is_active_in IC
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0031264 Cellular Component death-inducing signaling complex part_of IDA
    GO:0031264 Cellular Component death-inducing signaling complex part_of TAS
    GO:0005886 Cellular Component plasma membrane located_in IDA
    GO:0097342 Cellular Component ripoptosome part_of IDA
    Pathways
    Name DB ID
    Apoptosis Reactome R-HSA-109581
    Caspase activation via Death Receptors in the presence of ligand Reactome R-HSA-140534
    Signal Transduction Reactome R-HSA-162582
    Disease Reactome R-HSA-1643685
    Toll Like Receptor 4 (TLR4) Cascade Reactome R-HSA-166016
    MyD88-independent TLR4 cascade Reactome R-HSA-166166
    Toll Like Receptor 3 (TLR3) Cascade Reactome R-HSA-168164
    Innate Immune System Reactome R-HSA-168249
    Immune System Reactome R-HSA-168256
    Toll-like Receptor Cascades Reactome R-HSA-168898
    DDX58/IFIH1-mediated induction of interferon-alpha/beta Reactome R-HSA-168928
    TRIF-mediated programmed cell death Reactome R-HSA-2562578
    Regulation by c-FLIP Reactome R-HSA-3371378
    RIPK1-mediated regulated necrosis Reactome R-HSA-5213460
    Regulated Necrosis Reactome R-HSA-5218859
    CASP8 activity is inhibited Reactome R-HSA-5218900
    Caspase activation via extrinsic apoptotic signalling pathway Reactome R-HSA-5357769
    TNFR1-induced proapoptotic signaling Reactome R-HSA-5357786
    Programmed Cell Death Reactome R-HSA-5357801
    Regulation of TNFR1 signaling Reactome R-HSA-5357905
    Regulation of necroptotic cell death Reactome R-HSA-5675482
    Dimerization of procaspase-8 Reactome R-HSA-69416
    Death Receptor Signaling Reactome R-HSA-73887
    FasL/ CD95L signaling Reactome R-HSA-75157
    TRAIL signaling Reactome R-HSA-75158
    TNF signaling Reactome R-HSA-75893
    TLR3-mediated TICAM1-dependent programmed cell death Reactome R-HSA-9013957
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Reactome R-HSA-933543
    TRIF(TICAM1)-mediated TLR4 signaling Reactome R-HSA-937061
    Diseases of programmed cell death Reactome R-HSA-9645723
    Defective RIPK1-mediated regulated necrosis Reactome R-HSA-9693928
    Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
    Measles virus infection (WP4630) WikiPathways WP4630_r123414
    Hepatitis B infection (WP4666) WikiPathways WP4666_r123495
    Nanomaterial induced apoptosis (WP2507) WikiPathways WP2507_r123897
    Apoptosis modulation by HSP70 (WP384) WikiPathways WP384_r121706
    Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
    SARS-CoV-2 innate immunity evasion and cell-specific immune response (WP5039) WikiPathways WP5039_r124653
    IL-18 signaling pathway (WP4754) WikiPathways WP4754_r115147
    Toll-like receptor signaling pathway (WP75) WikiPathways WP75_r119233
    Fas ligand pathway and stress induction of heat shock proteins (WP314) WikiPathways WP314_r121827
    Host-pathogen interaction of human coronaviruses - apoptosis (WP4864) WikiPathways WP4864_r124634
    Apoptosis (WP254) WikiPathways WP254_r118382
    Pro-survival signaling of neuroprotectin D1 (WP5182) WikiPathways WP5182_r122168
    Head and neck squamous cell carcinoma (WP4674) WikiPathways WP4674_r123494
    TNF-related weak inducer of apoptosis (TWEAK) signaling pathway (WP2036) WikiPathways WP2036_r120940
    Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
    TNF-alpha signaling pathway (WP231) WikiPathways WP231_r124583
    Apoptosis modulation and signaling (WP1772) WikiPathways WP1772_r120736
    Nanoparticle triggered regulated necrosis (WP2513) WikiPathways WP2513_r119820
    VEGFA-VEGFR2 signaling pathway (WP3888) WikiPathways WP3888_r116782
    Novel intracellular components of RIG-I-like receptor pathway (WP3865) WikiPathways WP3865_r123636
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_003824 4 mRNA None NC_000011 Reference