TRIM5

tripartite motif containing 5
General Information
Name tripartite motif containing 5
Alias
  • tripartite motif-containing protein 5
  • RING-type E3 ubiquitin transferase TRIM5
  • ring finger protein 88
  • tripartite motif protein TRIM5
Synonyms RNF88 TRIM5alpha
Gene_family Tripartite motif family|Ring finger proteins
organism Homo sapiens
entrez_id 85363
location 11p15.4
transcript_count 19
exon_count 12
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
      Stringdb Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also [...]
      nextProt Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    TRIM5 BioGRID DDX50 GeneID BioGRID Cross-Linking-MS (XL-MS)
    TRIM5 BioGRID ARRDC3 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID DSCR9 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID ITSN1 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID CFTR GeneID BioGRID Affinity Capture-MS; PCA
    TRIM5 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID EXOC4 GeneID BioGRID Co-fractionation
    TRIM5 BioGRID API5 GeneID BioGRID Co-fractionation
    TRIM5 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID NFYA GeneID BioGRID Co-fractionation
    TRIM5 BioGRID PHB2 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID LRPPRC GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID RB1CC1 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID ATG13 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID N4BP1 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID NCOA4 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID NIPSNAP2 GeneID BioGRID Affinity Capture-Western; Co-localization
    TRIM5 BioGRID CANX GeneID BioGRID Co-localization
    TRIM5 BioGRID TRIM34 GeneID BioGRID Affinity Capture-MS; Two-hybrid
    TRIM5 BioGRID DCXR GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID TFPT GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID YARS1 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID DAXX GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID TRIM6-TRIM34 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID CUEDC1 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID FAM9C GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID UBQLN2 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID gag GeneID BioGRID Co-crystal Structure; Co-fractionation; Co-localization; Reconstituted Complex
    TRIM5 BioGRID KIF20A GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID KIF14 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID TSGA10IP GeneID BioGRID Two-hybrid
    TRIM5 BioGRID MTURN GeneID BioGRID Two-hybrid
    TRIM5 BioGRID MPP7 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID NTAQ1 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID UBASH3A GeneID BioGRID Two-hybrid
    TRIM5 BioGRID YES1 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID SGTA GeneID BioGRID Two-hybrid
    TRIM5 BioGRID UBE2K GeneID BioGRID Two-hybrid
    TRIM5 BioGRID EHHADH GeneID BioGRID Two-hybrid
    TRIM5 BioGRID UBE2N GeneID BioGRID Biochemical Activity; Co-crystal Structure; Reconstituted Complex; Two-hybrid
    TRIM5 BioGRID TRIM5 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Co-purification; Reconstituted Complex; Two-hybrid
    TRIM5 BioGRID UBE2W GeneID BioGRID Reconstituted Complex
    TRIM5 BioGRID SOCS1 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID RUNX1 GeneID BioGRID Reconstituted Complex
    TRIM5 BioGRID COIL GeneID BioGRID Co-localization
    TRIM5 BioGRID SUMO1 GeneID BioGRID Co-localization; Reconstituted Complex
    TRIM5 BioGRID LGALS8 GeneID BioGRID Reconstituted Complex
    TRIM5 BioGRID LGALS3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TRIM5 BioGRID CREB1 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID PIAS1 GeneID BioGRID Biochemical Activity
    TRIM5 BioGRID UL123 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID UBE2D3 GeneID BioGRID Reconstituted Complex; Two-hybrid
    TRIM5 BioGRID Ppp2ca GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID UBC GeneID BioGRID Biochemical Activity
    TRIM5 BioGRID UBE2D2 GeneID BioGRID Reconstituted Complex; Two-hybrid
    TRIM5 BioGRID PRKCG GeneID BioGRID Reconstituted Complex
    TRIM5 BioGRID OTUD6A GeneID BioGRID Two-hybrid
    TRIM5 BioGRID OTUB2 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID USP21 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID USP39 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID USP15 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID USP2 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID USP5 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID TNFAIP3 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID MAP3K7 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID MAP3K1 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID TAB3 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID TAB2 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID IKBKG GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID MKRN3 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID TRIM21 GeneID BioGRID Reconstituted Complex
    TRIM5 BioGRID MNAT1 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID TRIM6 GeneID BioGRID Reconstituted Complex; Two-hybrid
    TRIM5 BioGRID TRIM35 GeneID BioGRID Reconstituted Complex
    TRIM5 BioGRID TRIM32 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID UBB GeneID BioGRID Two-hybrid
    TRIM5 BioGRID PSMD7 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID PSMC5 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID PSMC4 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID PSMC2 GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
    TRIM5 BioGRID MAP3K11 GeneID BioGRID Affinity Capture-Western
    TRIM5 BioGRID ZWINT GeneID BioGRID Affinity Capture-MS
    TRIM5 BioGRID LZTR1 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID PCBD1 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID EWSR1 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID UBE2U GeneID BioGRID Two-hybrid
    TRIM5 BioGRID UBE2D4 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID UBE2V2 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID UBE2V1 GeneID BioGRID Two-hybrid
    TRIM5 BioGRID UBE2H GeneID BioGRID Two-hybrid
    TRIM5 BioGRID UBE2D1 GeneID BioGRID Two-hybrid
    TRIM5 Protein BTBD2 GeneID HPRD None
    TRIM5 Protein BTBD1 GeneID HPRD None
    TRIM5 Protein TRIM6 GeneID HPRD None
    TRIM5 Protein TRIM5 GeneID HPRD None
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TRIM5 CCR3 0 0 81 223 1 1
    TRIM5 CASP1 0 0 232 366 1 2
    TRIM5 TNFSF10 0 0 139 201 1 2
    TRIM5 CEACAM6 0 0 0 187 1 1
    TRIM5 GBP4 0 0 155 188 1 1
    TRIM5 SIGLEC1 0 0 108 167 1 1
    TRIM5 LHPP 0 0 167 194 1 1
    TRIM5 MEX3D 0 0 67 195 1 1
    TRIM5 TMEM173 0 0 194 339 1 1
    TRIM5 UBE3C 0 0 94 217 1 1
    TRIM5 VCP 0 0 108 178 1 2
    TRIM5 HIVEP3 0 0 57 185 1 1
    TRIM5 PIP5K1A 0 0 105 217 1 1
    TRIM5 TICAM1 0 0 155 154 1 1
    TRIM5 DTX4 0 0 113 168 1 1
    TRIM5 MEX3B 0 0 65 156 1 1
    TRIM5 CCR5 0 0 636 699 1 1
    TRIM5 RTP4 0 0 181 276 1 1
    TRIM5 PNRC1 0 0 175 509 1 1
    TRIM5 USP4 0 0 193 229 1 1
    TRIM5 APOL6 0 0 70 152 1 1
    TRIM5 MIB2 0 0 66 158 1 1
    TRIM5 CD69 0 0 181 212 1 1
    TRIM5 APOBEC3A 0 0 452 545 1 1
    TRIM5 SAE1 0 0 124 166 1 1
    TRIM5 MNAT1 192 0 0 210 1 1
    TRIM5 CD8A 0 0 422 448 1 1
    TRIM5 SH3RF2 0 0 92 167 1 1
    TRIM5 PSMB8 0 0 123 226 1 1
    TRIM5 HAVCR2 0 0 74 341 1 1
    TRIM5 FUZ 0 0 205 205 1 1
    TRIM5 COIL 273 0 0 273 1 1
    TRIM5 TRIM3 0 0 500 251 1 1
    TRIM5 TMLHE 0 0 827 830 1 1
    TRIM5 TLR5 0 0 155 168 1 1
    TRIM5 TPM1 0 0 0 169 1 1
    TRIM5 FGF4 0 0 90 151 1 1
    TRIM5 UBE2N 747 0 978 994 1 1
    TRIM5 GABARAPL1 0 0 210 306 1 2
    TRIM5 SETDB1 0 0 108 183 1 1
    TRIM5 RGPD2 0 0 520 531 1 1
    TRIM5 ACTB 0 0 273 313 1 1
    TRIM5 SLC35G3 0 0 120 180 1 1
    TRIM5 RNF5 0 0 219 225 1 1
    TRIM5 KIR3DL3 0 0 149 235 1 1
    TRIM5 HIST1H4J 0 0 0 153 1 1
    TRIM5 IFI44L 0 0 156 245 1 1
    TRIM5 TRIM39-RPP21 0 0 0 189 1 1
    TRIM5 ENSG00000279782 0 0 0 434 1 1
    TRIM5 DCLK1 0 0 0 171 1 1
    TRIM5 UBAP2 0 0 82 171 1 1
    TRIM5 LRRFIP1 0 0 182 181 1 1
    TRIM5 TRIM62 0 0 392 161 1 1
    TRIM5 COMMD1 0 0 266 266 1 1
    TRIM5 HERC4 0 0 150 386 1 1
    TRIM5 PHF11 0 0 93 177 1 1
    TRIM5 SGTA 73 0 119 161 1 1
    TRIM5 APOBEC3H 0 0 517 517 1 1
    TRIM5 FLOT1 0 0 444 444 1 1
    TRIM5 APOBEC1 0 0 217 221 1 1
    TRIM5 BSG 0 0 386 386 1 1
    TRIM5 CUL5 0 0 458 495 1 1
    TRIM5 DNM2 0 0 109 155 1 1
    TRIM5 MAVS 0 0 414 423 1 1
    TRIM5 MAP1LC3C 0 0 202 299 1 2
    TRIM5 KIF20A 270 0 0 303 1 1
    TRIM5 PPIAL4F 0 0 0 434 1 1
    TRIM5 CCL4 0 0 266 282 1 1
    TRIM5 BLMH 0 0 0 194 1 1
    TRIM5 AIM2 0 0 271 298 1 1
    TRIM5 DDX58 0 0 660 702 1 1
    TRIM5 UBE2D4 108 0 150 235 1 1
    TRIM5 HIST1H4E 0 0 0 153 1 1
    TRIM5 OTUB2 192 0 0 192 1 1
    TRIM5 TPM4 0 0 0 169 1 1
    TRIM5 TRIM21 270 0 864 385 1 1
    TRIM5 ANAPC1 0 0 74 187 1 1
    TRIM5 ZNRD1 0 0 202 202 1 1
    TRIM5 TRIM16L 0 0 241 240 1 1
    TRIM5 IFIH1 0 0 415 492 1 1
    TRIM5 HIST2H3PS2 0 0 72 170 1 1
    TRIM5 CISH 0 0 150 163 1 1
    TRIM5 MX2 0 0 710 728 1 1
    TRIM5 PPIB 0 0 193 212 1 1
    TRIM5 ACAD10 0 0 0 153 1 1
    TRIM5 TRIM35 270 0 371 384 1 1
    TRIM5 APOBEC3F 0 0 654 712 1 1
    TRIM5 RNF148 0 0 108 197 1 1
    TRIM5 TLR7 0 0 406 455 1 1
    TRIM5 RNF144B 0 0 67 158 1 1
    TRIM5 CNOT7 0 0 55 188 1 1
    TRIM5 NLRP5 0 0 73 184 1 1
    TRIM5 RNF19A 0 0 122 191 1 1
    TRIM5 PSG7 0 0 134 188 1 1
    TRIM5 MX1 0 0 505 572 1 1
    TRIM5 TAB1 0 0 166 194 1 1
    TRIM5 RARG 0 0 229 274 1 1
    TRIM5 IL18 0 0 156 163 1 1
    TRIM5 PARP12 0 0 134 220 1 1
    TRIM5 MYC 0 0 472 493 1 2
    TRIM5 IRGM 0 0 138 247 1 2
    TRIM5 IFITM3 0 0 382 400 1 1
    TRIM5 RARRES3 0 0 142 235 1 1
    TRIM5 PPIG 0 0 458 464 1 1
    TRIM5 UBE2D1 108 0 242 318 1 1
    TRIM5 PI3 0 0 181 181 1 1
    TRIM5 TAB2 270 0 801 852 1 1
    TRIM5 UBE2K 130 0 66 258 1 1
    TRIM5 LNPEP 0 0 0 258 1 1
    TRIM5 TLR1 0 0 125 383 1 1
    TRIM5 CH25H 0 0 242 241 1 1
    TRIM5 DHX58 0 0 262 311 1 1
    TRIM5 FURIN 0 0 113 221 1 1
    TRIM5 CD80 0 0 142 161 1 1
    TRIM5 FKBP7 0 0 242 273 1 1
    TRIM5 UBA1 0 0 171 220 1 1
    TRIM5 RPRD2 0 0 163 163 1 1
    TRIM5 HIST1H4L 0 0 0 153 1 1
    TRIM5 AGO4 0 0 0 169 1 1
    TRIM5 TAX1BP1 0 0 162 161 1 2
    TRIM5 RUFY1 0 0 67 150 1 1
    TRIM5 RNF115 0 0 204 214 1 1
    TRIM5 EXO1 0 0 87 243 1 1
    TRIM5 SPECC1 0 0 0 158 1 1
    TRIM5 EDARADD 0 0 0 156 1 1
    TRIM5 IFITM10 0 0 127 154 1 1
    TRIM5 KIR3DL2 0 0 117 206 1 1
    TRIM5 TRIM24 0 0 267 379 1 1
    TRIM5 IRF9 0 0 261 297 1 1
    TRIM5 MYD88 0 0 218 229 1 1
    TRIM5 HIST1H4I 0 0 0 153 1 1
    TRIM5 UCHL5 0 0 0 204 1 1
    TRIM5 ZNF337 0 0 160 242 1 1
    TRIM5 RHPN1 0 0 0 219 1 1
    TRIM5 TRIM23 0 0 504 514 1 1
    TRIM5 AGO2 0 0 109 228 1 1
    TRIM5 ZFAND4 0 0 103 237 1 1
    TRIM5 RNF126 0 0 74 150 1 1
    TRIM5 ZFYVE19 0 0 95 223 1 1
    TRIM5 PIN1 0 0 81 341 1 1
    TRIM5 TRIM13 0 0 323 216 1 2
    TRIM5 MS4A12 0 0 96 158 1 1
    TRIM5 MAP1LC3A 0 0 453 520 1 2
    TRIM5 FCGR3A 0 0 141 160 1 1
    TRIM5 THOP1 0 0 0 226 1 1
    TRIM5 XPO1 0 0 256 256 1 1
    TRIM5 HERC5 0 0 268 367 1 1
    TRIM5 B7RP1 0 0 0 199 1 1
    TRIM5 IL1B 0 0 203 220 1 1
    TRIM5 TRIM66 0 0 310 415 1 1
    TRIM5 SP1 0 0 120 183 1 1
    TRIM5 PSMC2 312 0 645 768 1 1
    TRIM5 OAS1 0 0 391 454 1 1
    TRIM5 IL6 0 0 236 246 1 1
    TRIM5 NFYB 0 0 0 162 1 1
    TRIM5 SHE 0 0 108 155 1 1
    TRIM5 TRIM37 0 0 456 226 1 1
    TRIM5 RTF1 0 0 134 153 1 1
    TRIM5 NLRP1 0 0 123 187 1 1
    TRIM5 APOBEC3G 0 0 868 890 1 1
    TRIM5 ABAT 0 0 0 165 1 1
    TRIM5 OR52H1 0 0 182 528 1 1
    TRIM5 RANBP2 0 0 529 544 1 1
    TRIM5 MAPKBP1 0 0 74 154 1 1
    TRIM5 CTDSPL2 0 0 139 432 1 1
    TRIM5 LRSAM1 0 0 181 206 1 2
    TRIM5 HAVCR1 0 0 48 257 1 1
    TRIM5 CCL5 0 0 261 280 1 1
    TRIM5 BIRC2 0 0 52 172 1 1
    TRIM5 IFNG 0 0 127 321 1 2
    TRIM5 TLR4 0 0 269 299 1 1
    TRIM5 GABARAPL2 0 0 233 326 1 2
    TRIM5 NMI 0 0 234 575 1 1
    TRIM5 UBE2V2 108 0 391 573 1 1
    TRIM5 TAB3 270 0 527 671 1 2
    TRIM5 CCL4L1 0 0 235 252 1 1
    TRIM5 IL2 0 0 341 369 1 1
    TRIM5 TLR6 0 0 95 323 1 1
    TRIM5 ZC3HAV1 0 0 452 491 1 1
    TRIM5 FBXL19 0 0 0 180 1 1
    TRIM5 BECN1 0 0 660 663 1 2
    TRIM5 AKIRIN2 0 0 108 178 1 1
    TRIM5 HIST1H4G 0 0 0 153 1 1
    TRIM5 MEX3C 0 0 113 200 1 1
    TRIM5 PIAS1 270 0 184 411 1 1
    TRIM5 IPO7 0 0 155 172 1 1
    TRIM5 SEC62 0 0 74 192 1 1
    TRIM5 CD81 0 0 166 165 1 1
    TRIM5 SLFN13 0 0 108 260 1 1
    TRIM5 NUP155 0 0 143 251 1 1
    TRIM5 ZNF598 0 0 87 166 1 1
    TRIM5 IFNL3 0 0 194 194 1 1
    TRIM5 TCEB1 0 0 261 279 1 1
    TRIM5 BIRC7 0 0 92 197 1 1
    TRIM5 RXRA 0 0 172 203 1 1
    TRIM5 ZNRF2 0 0 90 200 1 1
    TRIM5 ENSG00000257767 0 0 0 189 1 1
    TRIM5 LNX2 0 0 142 199 1 1
    TRIM5 APOO 0 0 73 165 1 1
    TRIM5 DTX2 0 0 94 161 1 1
    TRIM5 HLA-B 0 0 269 269 1 1
    TRIM5 APOBEC3C 0 0 409 426 1 1
    TRIM5 FBXO17 0 0 108 197 1 1
    TRIM5 ATG16L1 0 0 454 466 1 2
    TRIM5 PPIAL4D 0 0 0 434 1 1
    TRIM5 NOD2 0 0 213 222 1 1
    TRIM5 CIITA 0 0 134 215 1 1
    TRIM5 NLRP3 0 0 181 202 1 2
    TRIM5 KIR2DL1 0 0 142 161 1 1
    TRIM5 PLA2G6 0 0 0 172 1 1
    TRIM5 MARCH9 0 0 74 162 1 1
    TRIM5 UBE2V1 108 0 622 655 1 1
    TRIM5 SMURF1 0 0 134 154 1 1
    TRIM5 DDX6 0 0 104 210 1 1
    TRIM5 FBXO27 0 0 93 185 1 1
    TRIM5 UBA2 0 0 118 171 1 1
    TRIM5 RNF151 0 0 125 215 1 1
    TRIM5 TRIM22 0 0 766 231 1 1
    TRIM5 HIST1H4K 0 0 0 153 1 1
    TRIM5 FKBP2 0 0 135 230 1 1
    TRIM5 TRIM67 0 0 181 199 1 1
    TRIM5 AMBRA1 0 0 439 448 1 2
    TRIM5 RARB 0 0 242 278 1 1
    TRIM5 AGO1 0 0 0 169 1 1
    TRIM5 PDCD1LG2 0 0 0 298 1 1
    TRIM5 TRIM47 0 0 166 191 1 1
    TRIM5 ASCL3 0 0 75 157 1 1
    TRIM5 YARS 229 0 0 228 1 1
    TRIM5 BST2 0 0 857 863 1 1
    TRIM5 TRIM51 0 0 412 232 1 1
    TRIM5 ZFPL1 0 0 90 156 1 1
    TRIM5 SNAI1 270 0 0 270 1 1
    TRIM5 IL10 0 0 222 222 1 1
    TRIM5 RNF128 0 0 103 159 1 1
    TRIM5 TRIM45 0 0 93 168 1 1
    TRIM5 TRIM46 0 0 150 212 1 1
    TRIM5 FCGR3B 0 0 139 158 1 1
    TRIM5 CCL3 0 0 241 257 1 1
    TRIM5 TRIM54 0 0 323 389 1 1
    TRIM5 HLA-A 0 0 181 181 1 1
    TRIM5 APOBEC3D 0 0 464 555 1 1
    TRIM5 TRIM32 270 0 504 434 1 1
    TRIM5 UNG 0 0 151 161 1 1
    TRIM5 RNF26 0 0 180 209 1 1
    TRIM5 NONO 0 0 103 172 1 1
    TRIM5 ULK1 0 0 181 181 1 2
    TRIM5 MAP4 0 0 0 364 1 1
    TRIM5 UBE3B 0 0 73 157 1 1
    TRIM5 CCNL2 0 0 135 171 1 1
    TRIM5 OLFML1 0 0 0 156 1 1
    TRIM5 UBC 270 0 91 341 1 1
    TRIM5 BTBD1 213 0 907 923 1 1
    TRIM5 MAP1LC3B 0 0 230 526 1 2
    TRIM5 AGL 0 0 46 160 1 1
    TRIM5 TSG101 0 0 321 321 1 2
    TRIM5 MRS2 0 0 0 269 1 1
    TRIM5 IRF1 0 0 283 316 1 1
    TRIM5 KIAA0368 0 0 0 233 1 1
    TRIM5 RNF114 0 0 107 244 1 1
    TRIM5 CALCOCO2 0 0 297 297 1 2
    TRIM5 UBE2D2 654 0 518 830 1 1
    TRIM5 IFNB1 0 0 469 476 1 1
    TRIM5 UBQLN2 70 0 84 154 1 2
    TRIM5 OPTN 0 0 217 217 1 2
    TRIM5 NRD1 0 0 0 276 1 1
    TRIM5 MKRN3 192 0 107 247 1 1
    TRIM5 EMB 0 0 195 195 1 1
    TRIM5 ITCH 0 0 122 163 1 1
    TRIM5 USP14 0 0 62 230 1 1
    TRIM5 RBM8A 0 0 455 455 1 1
    TRIM5 RNF113A 0 0 117 252 1 1
    TRIM5 NAIP 0 0 94 157 1 1
    TRIM5 ARIH2 0 0 89 198 1 1
    TRIM5 PDCD6IP 0 0 47 154 1 1
    TRIM5 CLEC10A 0 0 212 308 1 1
    TRIM5 VDR 0 0 134 166 1 1
    TRIM5 IFITM1 0 0 381 398 1 1
    TRIM5 NBR1 0 0 259 323 1 2
    TRIM5 RNF4 0 0 252 268 1 1
    TRIM5 TNF 0 0 284 301 1 1
    TRIM5 C19orf48 0 0 0 302 1 1
    TRIM5 ITIH4 0 0 507 507 1 1
    TRIM5 IRF7 0 0 459 525 1 1
    TRIM5 CLASRP 0 0 57 230 1 1
    TRIM5 IFI35 0 0 282 382 1 1
    TRIM5 C19orf66 0 0 245 244 1 1
    TRIM5 PCBD1 118 0 0 152 1 1
    TRIM5 FKBP1C 0 0 249 279 1 1
    TRIM5 IFI16 0 0 407 462 1 1
    TRIM5 RNF166 0 0 115 178 1 1
    TRIM5 TNFAIP3 192 0 92 246 1 1
    TRIM5 PCDH10 0 0 0 181 1 1
    TRIM5 CD274 0 0 67 186 1 1
    TRIM5 HERC3 0 0 123 375 1 1
    TRIM5 TRIM65 0 0 246 191 1 1
    TRIM5 NTRK1 0 0 0 181 1 1
    TRIM5 UBL4A 0 0 65 172 1 1
    TRIM5 CBL 0 0 76 218 1 1
    TRIM5 DDX60 0 0 341 461 1 1
    TRIM5 REM1 0 0 102 212 1 1
    TRIM5 HIST1H4B 0 0 0 153 1 1
    TRIM5 BARD1 0 0 99 163 1 1
    TRIM5 TRIM42 0 0 181 243 1 1
    TRIM5 HELZ2 0 0 98 167 1 1
    TRIM5 KIR3DL1 0 0 257 274 1 1
    TRIM5 KIF14 270 0 0 302 1 1
    TRIM5 RNASEL 0 0 454 497 1 1
    TRIM5 DCST1 0 0 109 200 1 1
    TRIM5 IFI44 0 0 217 285 1 1
    TRIM5 CTLA4 0 0 252 252 1 1
    TRIM5 ZFYVE1 0 0 170 217 1 2
    TRIM5 IFIT1 0 0 382 448 1 1
    TRIM5 CDA 0 0 509 542 1 1
    TRIM5 CCR4 0 0 0 190 1 1
    TRIM5 GHITM 0 0 45 193 1 1
    TRIM5 RBX1 0 0 171 309 1 1
    TRIM5 RNF167 0 0 95 159 1 1
    TRIM5 JAK1 0 0 134 171 1 1
    TRIM5 ICOS 0 0 0 218 1 1
    TRIM5 EIF2S1 0 0 139 421 1 2
    TRIM5 SLFN11 0 0 506 516 1 1
    TRIM5 TRIM14 0 0 368 221 1 1
    TRIM5 PDZD8 0 0 294 294 1 1
    TRIM5 LGALS3 270 0 438 572 1 1
    TRIM5 TRIM52 0 0 391 203 1 1
    TRIM5 PLSCR1 0 0 96 200 1 1
    TRIM5 UTP14A 0 0 0 155 1 1
    TRIM5 SAMD9L 0 0 175 265 1 1
    TRIM5 SMARCC1 0 0 0 175 1 1
    TRIM5 USP2 192 0 0 192 1 1
    TRIM5 IRF3 0 0 465 473 1 1
    TRIM5 TRIM2 0 0 322 173 1 1
    TRIM5 CCL3L3 0 0 252 268 1 1
    TRIM5 TRIM36 0 0 181 186 1 1
    TRIM5 FBXL17 0 0 74 171 1 1
    TRIM5 NSMCE1 0 0 90 181 1 1
    TRIM5 MAP3K1 270 0 0 285 1 1
    TRIM5 KIR2DL4 0 0 160 179 1 1
    TRIM5 TLR9 0 0 260 277 1 1
    TRIM5 PDLIM2 0 0 66 159 1 1
    TRIM5 CXCL10 0 0 227 261 1 1
    TRIM5 RNF7 0 0 171 185 1 1
    TRIM5 BTBD2 161 0 907 918 1 1
    TRIM5 SUPT16H 0 0 0 281 1 1
    TRIM5 GMFG 0 0 150 157 1 1
    TRIM5 ATL2 0 0 73 228 1 1
    TRIM5 UBR2 0 0 96 162 1 1
    TRIM5 IKBKB 0 0 184 197 1 1
    TRIM5 MARCH8 0 0 196 334 1 1
    TRIM5 PRKCG 270 0 0 270 1 1
    TRIM5 CD4 0 0 602 849 1 1
    TRIM5 MARCH6 0 0 74 157 1 1
    TRIM5 LY96 0 0 103 240 1 1
    TRIM5 GPN1 0 0 167 167 1 1
    TRIM5 RNF113B 0 0 113 248 1 1
    TRIM5 ZSWIM2 0 0 95 198 1 1
    TRIM5 TRIM6 681 0 810 707 1 1
    TRIM5 TRIM38 0 0 520 161 1 1
    TRIM5 SERINC3 0 0 562 562 1 1
    TRIM5 AMFR 0 0 95 155 1 1
    TRIM5 ENSG00000173366 0 0 260 277 1 1
    TRIM5 KCNK3 0 0 119 153 1 1
    TRIM5 PARD3B 0 0 141 202 1 1
    TRIM5 TRIM17 0 0 815 215 1 2
    TRIM5 TYK2 0 0 135 172 1 1
    TRIM5 TRIM11 0 0 594 162 1 1
    TRIM5 NLRP8 0 0 123 275 1 1
    TRIM5 TPP2 0 0 0 298 1 1
    TRIM5 ARIH1 0 0 83 165 1 1
    TRIM5 PARP14 0 0 0 206 1 1
    TRIM5 RING1 0 0 160 165 1 1
    TRIM5 COX18 0 0 74 150 1 1
    TRIM5 EIF2AK2 0 0 370 409 1 2
    TRIM5 PUM2 0 0 0 199 1 1
    TRIM5 CPSF6 0 0 629 642 1 1
    TRIM5 UTP14C 0 0 0 155 1 1
    TRIM5 MAST2 0 0 107 189 1 1
    TRIM5 PPIAL4C 0 0 0 434 1 1
    TRIM5 CDKN1A 0 0 155 168 1 2
    TRIM5 PJA1 0 0 74 180 1 1
    TRIM5 IFNAR2 0 0 162 161 1 1
    TRIM5 N4BP1 0 0 108 221 1 1
    TRIM5 PCGF6 0 0 74 157 1 1
    TRIM5 NUP85 0 0 134 153 1 1
    TRIM5 TRIM31 0 0 402 193 1 1
    TRIM5 UBAP1 0 0 90 154 1 1
    TRIM5 PTPRC 0 0 91 193 1 1
    TRIM5 MID1 0 0 504 263 1 1
    TRIM5 DDX4 0 0 68 170 1 1
    TRIM5 IFIT5 0 0 212 290 1 1
    TRIM5 SP100 0 0 243 317 1 1
    TRIM5 RANGAP1 0 0 180 179 1 1
    TRIM5 UBE2E1 0 0 157 184 1 1
    TRIM5 ATG13 0 0 150 178 1 2
    TRIM5 NLRX1 0 0 205 214 1 1
    TRIM5 GBP7 0 0 156 189 1 1
    TRIM5 CUL4A 0 0 224 490 1 1
    TRIM5 MKRN2 0 0 92 185 1 1
    TRIM5 SQSTM1 270 0 583 715 1 2
    TRIM5 SIM2 0 0 240 287 1 1
    TRIM5 IL4 0 0 164 163 1 1
    TRIM5 LGALS8 270 0 135 341 1 1
    TRIM5 OTUD6A 192 0 0 192 1 1
    TRIM5 BIRC3 0 0 0 162 1 1
    TRIM5 ALB 0 0 141 169 1 1
    TRIM5 CCL2 0 0 161 167 1 2
    TRIM5 RNF44 0 0 114 216 1 1
    TRIM5 IFI6 0 0 217 259 1 1
    TRIM5 ENPEP 0 0 298 298 1 1
    TRIM5 TRIM41 0 0 334 167 1 1
    TRIM5 CUL1 0 0 136 593 1 1
    TRIM5 CLEC1A 0 0 125 198 1 1
    TRIM5 FBXO9 0 0 0 151 1 1
    TRIM5 MAP3K11 270 0 46 285 1 1
    TRIM5 MARCH2 0 0 174 288 1 1
    TRIM5 GBP1 0 0 207 268 1 1
    TRIM5 DDX41 0 0 293 312 1 1
    TRIM5 DUT 0 0 284 284 1 1
    TRIM5 MB21D1 0 0 468 468 1 1
    TRIM5 MARCH3 0 0 81 163 1 1
    TRIM5 NANOS3 0 0 0 156 1 1
    TRIM5 GAB4 0 0 155 244 1 1
    TRIM5 RHPN2 0 0 67 289 1 1
    TRIM5 TPM2 0 0 0 169 1 1
    TRIM5 ANKRD30A 0 0 113 156 1 1
    TRIM5 CCR1 0 0 81 223 1 1
    TRIM5 ATL3 0 0 0 156 1 1
    TRIM5 DICER1 0 0 120 286 1 1
    TRIM5 TRIM55 0 0 289 388 1 1
    TRIM5 SERINC5 0 0 509 509 1 1
    TRIM5 CCR2 0 0 207 330 1 2
    TRIM5 PDE6B 0 0 113 154 1 1
    TRIM5 ISG20 0 0 293 308 1 1
    TRIM5 PPIAL4G 0 0 0 434 1 1
    TRIM5 TRAF6 0 0 324 323 1 2
    TRIM5 USP15 192 0 134 297 1 1
    TRIM5 TMEM154 0 0 280 280 1 1
    TRIM5 MEFV 0 0 452 193 1 2
    TRIM5 TOP1 0 0 646 653 1 1
    TRIM5 IFNA1 0 0 506 506 1 1
    TRIM5 RNF125 0 0 241 240 1 1
    TRIM5 IL15 0 0 155 175 1 1
    TRIM5 CBLB 0 0 120 181 1 1
    TRIM5 UBE2H 108 0 62 237 1 1
    TRIM5 HLTF 0 0 123 158 1 1
    TRIM5 TRIM33 0 0 261 307 1 1
    TRIM5 MARCH7 0 0 66 152 1 1
    TRIM5 TNPO3 0 0 520 550 1 1
    TRIM5 USP39 192 0 0 209 1 1
    TRIM5 OASL 0 0 335 432 1 1
    TRIM5 IFITM2 0 0 264 286 1 1
    TRIM5 CLEC4A 0 0 148 204 1 1
    TRIM5 CCNT1 0 0 324 375 1 1
    TRIM5 OAS3 0 0 323 382 1 1
    TRIM5 ZNRF4 0 0 88 161 1 1
    TRIM5 MPP7 265 0 0 276 1 1
    TRIM5 RPL36 0 0 0 161 1 1
    TRIM5 ZBP1 0 0 95 154 1 1
    TRIM5 TRIM15 0 0 423 174 1 1
    TRIM5 TDRP 0 0 0 288 1 1
    TRIM5 RNF10 0 0 89 175 1 1
    TRIM5 MAP3K7 270 0 305 483 1 1
    TRIM5 NUP153 0 0 517 532 1 1
    TRIM5 TRIM16 0 0 391 196 1 2
    TRIM5 TP53 0 0 155 168 1 2
    TRIM5 MDM2 0 0 107 395 1 1
    TRIM5 TNFRSF4 0 0 108 170 1 1
    TRIM5 NEDD8 0 0 98 158 1 1
    TRIM5 LAMP1 0 0 193 203 1 2
    TRIM5 RPN1 0 0 0 265 1 1
    TRIM5 TRIM8 0 0 338 234 1 1
    TRIM5 PHF7 0 0 75 174 1 1
    TRIM5 CD300C 0 0 261 261 1 1
    TRIM5 IFNA2 0 0 194 225 1 1
    TRIM5 ETNK1 0 0 67 150 1 1
    TRIM5 HDAC6 0 0 134 190 1 2
    TRIM5 RNF111 0 0 95 201 1 1
    TRIM5 ERAP1 0 0 55 175 1 1
    TRIM5 SP140L 0 0 0 157 1 1
    TRIM5 BAZ1A 0 0 46 169 1 1
    TRIM5 APOBEC3B 0 0 365 755 1 1
    TRIM5 NEDD4 0 0 202 226 1 2
    TRIM5 TRIM27 0 0 405 183 1 1
    TRIM5 PPIAL4H 0 0 0 434 1 1
    TRIM5 CXCL8 0 0 149 174 1 1
    TRIM5 SUMO2 0 0 181 199 1 1
    TRIM5 OR52N2 0 0 405 405 1 1
    TRIM5 CTRL 0 0 0 160 1 1
    TRIM5 PIK3C3 0 0 164 195 1 2
    TRIM5 DEFB1 0 0 109 164 1 1
    TRIM5 TRIM71 0 0 115 355 1 1
    TRIM5 STAT1 0 0 303 393 1 1
    TRIM5 HIST1H4F 0 0 0 153 1 1
    TRIM5 CXCR4 0 0 470 706 1 2
    TRIM5 USP21 192 0 0 192 1 1
    TRIM5 ADAR 0 0 391 416 1 1
    TRIM5 TCTE1 0 0 129 234 1 1
    TRIM5 TRIM59 0 0 244 234 1 1
    TRIM5 MAP1LC3B2 0 0 0 409 1 2
    TRIM5 PSG6 0 0 0 190 1 1
    TRIM5 MOV10 0 0 341 387 1 1
    TRIM5 TRIM9 0 0 321 339 1 1
    TRIM5 UBE2D3 652 0 171 707 1 1
    TRIM5 ZNF645 0 0 113 176 1 1
    TRIM5 DHX9 0 0 129 178 1 1
    TRIM5 PASD1 0 0 95 160 1 1
    TRIM5 GAPDH 0 0 283 324 1 2
    TRIM5 APOBEC2 0 0 117 156 1 1
    TRIM5 PML 0 0 654 693 1 1
    TRIM5 HIST4H4 0 0 0 153 1 1
    TRIM5 CENPV 0 0 161 161 1 1
    TRIM5 GPR146 0 0 125 217 1 1
    TRIM5 OAS2 0 0 381 458 1 1
    TRIM5 ITGA4 0 0 96 188 1 1
    TRIM5 TLR10 0 0 59 182 1 1
    TRIM5 TRIM25 0 0 747 354 1 1
    TRIM5 TRIM34 469 0 825 514 1 1
    TRIM5 LGALS3BP 0 0 72 153 1 1
    TRIM5 PARP11 0 0 113 186 1 1
    TRIM5 EVPL 0 0 54 171 1 1
    TRIM5 TRAF3 0 0 217 217 1 2
    TRIM5 TLR2 0 0 185 216 1 1
    TRIM5 TMEM87B 0 0 0 188 1 1
    TRIM5 LILRA4 0 0 278 278 1 1
    TRIM5 ENSG00000277117 0 0 0 199 1 1
    TRIM5 CD86 0 0 125 164 1 1
    TRIM5 RNF141 0 0 108 199 1 1
    TRIM5 UBE2E3 0 0 74 160 1 1
    TRIM5 ARHGAP44 0 0 125 217 1 1
    TRIM5 BTRC 0 0 241 358 1 1
    TRIM5 RNF13 0 0 86 150 1 1
    TRIM5 ANKIB1 0 0 95 186 1 1
    TRIM5 GBP6 0 0 182 200 1 1
    TRIM5 MID2 0 0 614 614 1 1
    TRIM5 NANOS2 0 0 0 156 1 1
    TRIM5 RNF122 0 0 124 210 1 1
    TRIM5 CDK9 0 0 143 300 1 1
    TRIM5 NANOS1 0 0 0 156 1 1
    TRIM5 CHUK 0 0 213 237 1 1
    TRIM5 HIST2H4A 0 0 0 153 1 1
    TRIM5 TRIM44 0 0 210 220 1 1
    TRIM5 SAMHD1 0 0 805 852 1 1
    TRIM5 UBE2L6 0 0 206 273 1 1
    TRIM5 IFIT1B 0 0 148 190 1 1
    TRIM5 HDAC1 0 0 96 154 1 2
    TRIM5 DTX3L 0 0 124 242 1 1
    TRIM5 RNF150 0 0 91 159 1 1
    TRIM5 NLN 0 0 0 162 1 1
    TRIM5 PSMB9 0 0 124 212 1 1
    TRIM5 DAXX 0 0 164 201 1 1
    TRIM5 ATG12 0 0 160 159 1 2
    TRIM5 PPIA 0 0 899 940 1 1
    TRIM5 PSMC4 270 0 42 308 1 1
    TRIM5 CD28 0 0 261 277 1 1
    TRIM5 TRIM56 0 0 600 667 1 1
    TRIM5 HIST1H4A 0 0 0 153 1 1
    TRIM5 WSB2 0 0 161 200 1 1
    TRIM5 RCHY1 0 0 134 172 1 1
    TRIM5 OVGP1 0 0 181 181 1 1
    TRIM5 NFKBIA 0 0 225 263 1 1
    TRIM5 NUP98 0 0 112 193 1 1
    TRIM5 ASAP2 0 0 55 233 1 1
    TRIM5 RNF157 0 0 94 186 1 1
    TRIM5 ZNRF1 0 0 0 156 1 1
    TRIM5 SLFN14 0 0 109 177 1 1
    TRIM5 HECW2 0 0 67 157 1 1
    TRIM5 GABARAP 0 0 374 450 1 2
    TRIM5 CXCR6 0 0 156 155 1 1
    TRIM5 FMN1 0 0 0 167 1 1
    TRIM5 SP110 0 0 0 152 1 1
    TRIM5 TMEM87A 0 0 119 357 1 1
    TRIM5 CMPK2 0 0 108 180 1 1
    TRIM5 TRAT1 0 0 857 857 1 1
    TRIM5 ALDH1B1 0 0 52 152 1 1
    TRIM5 RNF39 0 0 117 177 1 1
    TRIM5 RARA 0 0 195 234 1 1
    TRIM5 CCR7 0 0 169 178 1 1
    TRIM5 IKBKG 270 0 178 391 1 1
    TRIM5 SUGT1 0 0 90 160 1 1
    TRIM5 LY6E 0 0 150 253 1 1
    TRIM5 ISG15 0 0 503 561 1 1
    TRIM5 USP18 0 0 203 314 1 1
    TRIM5 RANBP1 0 0 144 175 1 1
    TRIM5 CTHRC1 0 0 43 152 1 1
    TRIM5 PUM1 0 0 0 199 1 1
    TRIM5 HLA-C 0 0 235 235 1 1
    TRIM5 STAT2 0 0 283 317 1 1
    TRIM5 TPPP 0 0 140 156 1 1
    TRIM5 TLR8 0 0 294 305 1 1
    TRIM5 ATG5 0 0 702 702 1 2
    TRIM5 IRF5 0 0 181 198 1 1
    TRIM5 PSMC5 270 0 0 319 1 1
    TRIM5 HECTD3 0 0 117 153 1 1
    TRIM5 OR52B6 0 0 204 291 1 1
    TRIM5 ERVW-1 0 0 506 506 1 1
    TRIM5 PJA2 0 0 123 174 1 1
    TRIM5 DDX3X 0 0 149 242 1 1
    TRIM5 SHPRH 0 0 160 237 1 1
    TRIM5 HERC6 0 0 183 287 1 1
    TRIM5 CD209 0 0 391 401 1 1
    TRIM5 USP5 192 0 0 209 1 1
    TRIM5 IL7 0 0 140 167 1 1
    TRIM5 UBE2W 270 0 424 581 1 1
    TRIM5 RBM7 0 0 0 165 1 1
    TRIM5 TANK 0 0 165 165 1 1
    TRIM5 NHLRC1 0 0 113 168 1 1
    TRIM5 WDFY3 0 0 209 227 1 2
    TRIM5 APOB 0 0 394 709 1 1
    TRIM5 SOCS1 162 0 145 280 1 1
    TRIM5 RNF41 0 0 108 171 1 1
    TRIM5 GBP5 0 0 204 204 1 1
    TRIM5 HIST1H4H 0 0 0 153 1 1
    TRIM5 IFNAR1 0 0 261 261 1 1
    TRIM5 CUL4B 0 0 0 207 1 1
    TRIM5 CD63 0 0 96 259 1 1
    TRIM5 PSIP1 0 0 498 508 1 1
    TRIM5 IFIT2 0 0 284 355 1 1
    TRIM5 UBE2I 0 0 249 268 1 1
    TRIM5 CD207 0 0 309 321 1 1
    TRIM5 SLPI 0 0 140 167 1 1
    TRIM5 IDE 0 0 0 159 1 1
    TRIM5 MARCH1 0 0 150 232 1 1
    TRIM5 UBB 192 0 0 230 1 1
    TRIM5 MYCBP2 0 0 170 198 1 1
    TRIM5 RUNX1 270 0 0 296 1 1
    TRIM5 LST1 0 0 195 212 1 1
    TRIM5 CD46 0 0 194 211 1 1
    TRIM5 CD38 0 0 162 161 1 1
    TRIM5 HIST2H4B 0 0 0 153 1 1
    TRIM5 VPRBP 0 0 424 445 1 1
    TRIM5 XPR1 0 0 206 328 1 1
    TRIM5 ZWINT 766 0 0 766 1 1
    TRIM5 LOC388210 0 0 0 302 1 1
    TRIM5 TRIM29 0 0 181 192 1 1
    TRIM5 DDB1 0 0 218 489 1 1
    TRIM5 SKP1 0 0 170 227 1 1
    TRIM5 HIST1H4D 0 0 0 153 1 1
    TRIM5 TBK1 0 0 325 351 1 2
    TRIM5 RNASE7 0 0 262 278 1 1
    TRIM5 RSAD2 0 0 466 522 1 1
    TRIM5 PARP9 0 0 96 238 1 1
    TRIM5 TRIM28 0 0 510 544 1 2
    TRIM5 TLR3 0 0 325 352 1 1
    TRIM5 SLFN12 0 0 134 208 1 1
    TRIM5 PSMD7 270 0 60 297 1 1
    TRIM5 SIM1 0 0 184 202 1 1
    TRIM5 TXNDC9 0 0 0 154 1 1
    TRIM5 IRF8 0 0 210 229 1 1
    TRIM5 MPHOSPH8 0 0 0 157 1 1
    TRIM5 ADA 0 0 157 156 1 1
    TRIM5 RAG1 0 0 118 206 1 1
    TRIM5 BBOX1 0 0 809 837 1 1
    TRIM5 CD34 0 0 275 348 1 1
    TRIM5 PSMC1 0 0 0 442 1 1
    TRIM5 UBA7 0 0 103 164 1 1
    TRIM5 AGO3 0 0 0 169 1 1
    TRIM5 RNF213 0 0 180 223 1 1
    TRIM5 TPM3 0 0 0 169 1 1
    TRIM5 GP2 0 0 125 151 1 1
    TRIM5 ADRM1 0 0 0 400 1 1
    TRIM5 RNF103 0 0 81 156 1 1
    TRIM5 SSRP1 0 0 0 196 1 1
    TRIM5 TCEB2 0 0 325 363 1 1
    TRIM5 KIR2DL3 0 0 158 177 1 1
    TRIM5 FBXL14 0 0 128 185 1 1
    TRIM5 TRIM69 0 0 455 206 1 1
    TRIM5 PPIAL4B 0 0 48 438 1 1
    TRIM5 FAS 0 0 178 190 1 2
    TRIM5 RNF133 0 0 112 173 1 1
    TRIM5 SUMO1 677 0 264 774 1 1
    TRIM5 RNF121 0 0 93 171 1 1
    TRIM5 IFIT3 0 0 270 374 1 1
    TRIM5 HIST1H4C 0 0 0 153 1 1
    TRIM5 RNF144A 0 0 81 179 1 1
    TRIM5 ACKR1 0 0 108 198 1 1
    TRIM5 CSF2 0 0 194 194 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0038187 Molecular Function pattern recognition receptor activity enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0042803 Molecular Function protein homodimerization activity enables IBA
    GO:0042803 Molecular Function protein homodimerization activity enables IPI
    GO:0019901 Molecular Function protein kinase binding enables IBA
    GO:0019901 Molecular Function protein kinase binding enables IPI
    GO:0030674 Molecular Function protein-macromolecule adaptor activity enables IPI
    GO:0003713 Molecular Function transcription coactivator activity enables IDA
    GO:0061630 Molecular Function ubiquitin protein ligase activity enables IBA
    GO:0004842 Molecular Function ubiquitin-protein transferase activity enables IDA
    GO:0008270 Molecular Function zinc ion binding enables IEA
    GO:0002218 Biological Process activation of innate immune response involved_in IDA
    GO:0006914 Biological Process autophagy involved_in IDA
    GO:0051607 Biological Process defense response to virus involved_in TAS
    GO:0046597 Biological Process host-mediated suppression of symbiont invasion involved_in IDA
    GO:0045087 Biological Process innate immune response involved_in IBA
    GO:0045087 Biological Process innate immune response involved_in IDA
    GO:0051091 Biological Process positive regulation of DNA-binding transcription factor activity involved_in IMP
    GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in IEA
    GO:0043410 Biological Process positive regulation of MAPK cascade involved_in IMP
    GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IMP
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IBA
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IDA
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IMP
    GO:0070534 Biological Process protein K63-linked ubiquitination involved_in IDA
    GO:0010468 Biological Process regulation of gene expression involved_in IBA
    GO:0031664 Biological Process regulation of lipopolysaccharide-mediated signaling pathway involved_in IMP
    GO:0032880 Biological Process regulation of protein localization involved_in IBA
    GO:0032880 Biological Process regulation of protein localization involved_in IMP
    GO:0046596 Biological Process regulation of viral entry into host cell involved_in IBA
    GO:0044790 Biological Process suppression of viral release by host involved_in IDA
    GO:0000932 Cellular Component P-body located_in IDA
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0005634 Cellular Component nucleus located_in IEA
    GO:1990462 Cellular Component omegasome colocalizes_with IDA
    Pathways
    Name DB ID
    Endoderm differentiation (WP2853) WikiPathways WP2853_r116557
    Mesodermal commitment pathway (WP2857) WikiPathways WP2857_r118395
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XR_007062522 1 miscRNA transcript variant X15 NC_000011 Reference
    XR_007062518 1 miscRNA transcript variant X9 NC_000011 Reference
    XR_007062519 1 miscRNA transcript variant X10 NC_000011 Reference
    XR_001748014 3 miscRNA transcript variant X6 NC_000011 Reference
    XR_007062521 1 miscRNA transcript variant X14 NC_000011 Reference
    XR_007062520 1 miscRNA transcript variant X13 NC_000011 Reference
    XR_007062517 1 miscRNA transcript variant X7 NC_000011 Reference
    XM_047427783 1 mRNA transcript variant X8 NC_000011 Reference
    XM_047427784 1 mRNA transcript variant X12 NC_000011 Reference
    XM_005253183 4 mRNA transcript variant X1 NC_000011 Reference
    XM_006718358 4 mRNA transcript variant X11 NC_000011 Reference
    NM_033034 3 mRNA transcript variant alpha NC_000011 Reference
    XM_017018461 3 mRNA transcript variant X5 NC_000011 Reference
    NM_001410958 1 mRNA transcript variant 4 NC_000011 Reference
    NM_033093 4 mRNA transcript variant delta NC_000011 Reference
    XM_011520426 4 mRNA transcript variant X4 NC_000011 Reference
    XM_005253184 4 mRNA transcript variant X2 NC_000011 Reference
    NM_033092 4 mRNA transcript variant gamma NC_000011 Reference
    XM_017018460 3 mRNA transcript variant X3 NC_000011 Reference