ATG4D

autophagy related 4D cysteine peptidase
General Information
Name autophagy related 4D cysteine peptidase
Alias
  • cysteine protease ATG4D
  • APG4 autophagy 4 homolog D
  • ATG4 autophagy related 4 homolog D
  • AUT-like 4 cysteine endopeptidase
  • autophagin-4
  • autophagy-related cysteine endopeptidase 4
  • autophagy-related protein 4 homolog D
  • cysteine protease involved in autophagy
Synonyms APG4-D APG4D AUTL4 HsAPG4D
Gene_family MicroRNA protein coding host genes|Autophagy related
organism Homo sapiens
entrez_id 84971
location 19p13.2
transcript_count 5
exon_count 10
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
      Stringdb Cysteine protease ATG4D; Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms; Belongs to the peptidase C54 family
      nextProt Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    ATG4D BioGRID XPO7 GeneID BioGRID Affinity Capture-MS
    ATG4D BioGRID PRPF40A GeneID BioGRID Affinity Capture-MS
    ATG4D BioGRID ATG4C GeneID BioGRID Affinity Capture-MS
    ATG4D BioGRID GOPC GeneID BioGRID Affinity Capture-MS
    ATG4D BioGRID IMPDH1 GeneID BioGRID Affinity Capture-MS
    ATG4D BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    ATG4D BioGRID TRIM55 GeneID BioGRID Two-hybrid
    ATG4D BioGRID MAP1LC3B GeneID BioGRID Reconstituted Complex
    ATG4D BioGRID GABARAP GeneID BioGRID Reconstituted Complex
    ATG4D BioGRID P4HA2 GeneID BioGRID Affinity Capture-MS
    ATG4D BioGRID GABARAPL1 GeneID BioGRID Biochemical Activity
    ATG4D BioGRID GABARAPL2 GeneID BioGRID Biochemical Activity
    ATG4D BioGRID CASP8 GeneID BioGRID Biochemical Activity
    ATG4D BioGRID CASP3 GeneID BioGRID Biochemical Activity
    StringDB
    A B experiments database textmining combined score hadb nhadb
    ATG4D CTDP1 0 0 0 276 1 1
    ATG4D NLRC4 0 0 143 164 1 2
    ATG4D VMP1 0 0 323 415 1 2
    ATG4D TMEM74 0 0 348 347 1 2
    ATG4D FBXL14 0 0 0 194 1 1
    ATG4D PINK1 0 0 181 296 1 2
    ATG4D PPP3CA 0 0 0 266 1 1
    ATG4D PDE5A 0 0 0 172 1 1
    ATG4D PEX6 0 0 0 187 1 1
    ATG4D DUS1L 0 0 0 296 1 1
    ATG4D PDE4B 0 0 0 165 1 1
    ATG4D TGFBI 0 0 0 175 1 1
    ATG4D TUBAL3 0 0 0 162 1 1
    ATG4D UBA7 0 0 0 205 1 1
    ATG4D ENSG00000250232 0 0 188 377 1 1
    ATG4D FOXO3 0 0 155 213 1 2
    ATG4D CNNM3 0 0 0 214 1 1
    ATG4D XPNPEP3 0 0 0 166 1 1
    ATG4D BNIP1 0 0 155 154 1 2
    ATG4D ATG3 0 0 627 915 1 2
    ATG4D TUBB2A 0 0 0 192 1 1
    ATG4D ATG2B 0 0 602 786 1 2
    ATG4D LRCH2 0 0 0 151 1 1
    ATG4D LAPTM4B 0 0 108 201 1 1
    ATG4D RGS19 0 0 308 390 1 2
    ATG4D RAB7B 0 0 128 262 1 1
    ATG4D MGAT4B 0 0 119 228 1 1
    ATG4D KLF8 0 0 0 152 1 1
    ATG4D PITPNB 0 0 0 150 1 1
    ATG4D FBXL22 0 0 0 163 1 1
    ATG4D ATP2A2 0 0 0 158 1 1
    ATG4D LPCAT3 0 0 0 190 1 1
    ATG4D CHIT1 0 0 0 188 1 1
    ATG4D TUBA1A 0 0 0 162 1 1
    ATG4D TECPR1 0 0 183 369 1 2
    ATG4D PITPNM2 0 0 0 150 1 1
    ATG4D RHEB 0 0 170 274 1 2
    ATG4D FBXL4 0 0 0 163 1 1
    ATG4D ABCG5 0 0 0 201 1 1
    ATG4D INF2 0 0 0 165 1 1
    ATG4D DHX30 0 0 108 200 1 1
    ATG4D PPP2CA 0 0 0 172 1 1
    ATG4D SPNS3 0 0 0 156 1 1
    ATG4D LRRC29 0 0 0 184 1 1
    ATG4D PRKAA1 0 0 210 295 1 2
    ATG4D FAM83G 0 0 193 198 1 1
    ATG4D FNBP1L 0 0 277 387 1 1
    ATG4D ITSN2 0 0 0 150 1 1
    ATG4D RAB3GAP1 0 0 87 310 1 1
    ATG4D NEDD4L 0 0 0 200 1 1
    ATG4D WDR45 0 0 322 479 1 2
    ATG4D ANAPC2 0 0 0 178 1 1
    ATG4D WDFY3 0 0 139 249 1 2
    ATG4D TUBB4B 0 0 90 239 1 1
    ATG4D LIG4 0 0 47 165 1 1
    ATG4D TECPR2 0 0 218 384 1 2
    ATG4D CASP2 0 0 89 176 1 1
    ATG4D VPS51 0 0 0 185 1 1
    ATG4D HIPK3 0 0 0 204 1 1
    ATG4D CHMP2A 0 0 0 182 1 2
    ATG4D WDR45B 0 0 298 461 1 1
    ATG4D IGBP1 0 0 0 158 1 1
    ATG4D CAP1 0 0 0 232 1 1
    ATG4D MAPK8IP3 0 0 0 162 1 1
    ATG4D CTSB 0 0 213 313 1 2
    ATG4D MCL1 0 0 210 210 1 2
    ATG4D SIRT1 0 0 134 285 1 2
    ATG4D TUBB 0 0 0 192 1 1
    ATG4D PDIK1L 0 0 0 471 1 1
    ATG4D ATG5 0 0 631 843 1 2
    ATG4D DUS3L 0 0 0 256 1 1
    ATG4D FAM179A 0 0 0 185 1 1
    ATG4D MUC20 0 0 90 152 1 1
    ATG4D ATG10 0 0 562 718 1 2
    ATG4D WDFY4 0 0 0 164 1 1
    ATG4D STMN1 0 0 458 457 1 1
    ATG4D AKT3 0 0 0 154 1 1
    ATG4D CTSD 0 0 141 241 1 2
    ATG4D ATG7 0 0 595 853 1 2
    ATG4D SLC44A1 0 0 0 172 1 1
    ATG4D FMN1 0 0 0 560 1 1
    ATG4D LRCH3 0 0 0 151 1 1
    ATG4D GABARAP 270 900 559 986 1 2
    ATG4D SOGA1 0 0 180 190 1 2
    ATG4D PTEN 0 0 156 206 1 2
    ATG4D PI4KB 0 0 0 167 1 1
    ATG4D WIPI1 0 0 503 746 1 2
    ATG4D DNM1L 0 0 84 197 1 2
    ATG4D KIAA0226 0 0 205 474 1 1
    ATG4D PRKAA2 0 0 75 173 1 2
    ATG4D ATAD2B 0 0 0 152 1 1
    ATG4D ONECUT2 0 0 0 178 1 1
    ATG4D ENSG00000258947 0 0 0 193 1 1
    ATG4D PSMC4 0 0 69 328 1 1
    ATG4D DIRAS3 0 0 155 175 1 2
    ATG4D FGF22 0 0 94 332 1 1
    ATG4D ATG12 0 0 565 845 1 2
    ATG4D TUBE1 0 0 0 190 1 1
    ATG4D CPSF1 0 0 0 158 1 1
    ATG4D FCHSD1 0 0 0 186 1 1
    ATG4D PITPNM3 0 0 0 150 1 1
    ATG4D FBXL7 0 0 0 163 1 1
    ATG4D PDE6C 0 0 0 165 1 1
    ATG4D CUL3 0 0 92 164 1 1
    ATG4D STAMBPL1 0 0 0 185 1 1
    ATG4D SLC44A5 0 0 0 172 1 1
    ATG4D HSPA5 0 0 96 194 1 2
    ATG4D CNNM4 0 0 0 214 1 1
    ATG4D PDE6A 0 0 0 165 1 1
    ATG4D DNM1 0 0 49 155 1 1
    ATG4D PDE7B 0 0 0 165 1 1
    ATG4D SNX2 0 0 0 186 1 1
    ATG4D PTK6 0 0 166 186 1 1
    ATG4D DDX43 0 0 115 211 1 1
    ATG4D PIM3 0 0 0 163 1 1
    ATG4D PMAIP1 0 0 154 153 1 1
    ATG4D SLC46A3 0 0 140 220 1 1
    ATG4D LRRK2 0 0 128 238 1 2
    ATG4D STK38L 0 0 0 210 1 1
    ATG4D ADCY10 0 0 0 241 1 1
    ATG4D FCHSD2 0 0 0 186 1 1
    ATG4D FYCO1 0 0 124 184 1 2
    ATG4D CASP6 0 0 182 214 1 1
    ATG4D ARHGAP4 0 0 0 207 1 1
    ATG4D DACT1 0 0 45 191 1 1
    ATG4D GAPDH 0 0 140 167 1 2
    ATG4D WWP1 0 0 59 173 1 1
    ATG4D BCKDHB 0 0 0 161 1 1
    ATG4D GRID2IP 0 0 0 160 1 1
    ATG4D MAP1LC3B2 0 0 296 627 1 2
    ATG4D MTOR 0 0 285 345 1 2
    ATG4D CARS 0 0 0 217 1 1
    ATG4D SPNS1 0 0 0 156 1 2
    ATG4D MAN2C1 0 0 0 207 1 1
    ATG4D TMEM184C 0 0 0 164 1 1
    ATG4D ENDOG 0 0 97 186 1 1
    ATG4D SCPEP1 0 0 0 187 1 1
    ATG4D SLC44A3 0 0 0 172 1 1
    ATG4D PIK3C3 0 0 500 732 1 2
    ATG4D ACAN 0 0 0 165 1 1
    ATG4D UBE2G1 0 0 0 197 1 1
    ATG4D CTSL 0 0 123 170 1 1
    ATG4D BAG3 0 0 88 295 1 2
    ATG4D NEDD4 0 0 0 200 1 2
    ATG4D POSTN 0 0 0 175 1 1
    ATG4D FBXL12 0 0 0 163 1 1
    ATG4D RAB5A 0 0 415 461 1 2
    ATG4D SP140L 0 0 188 213 1 1
    ATG4D MFN2 0 0 122 317 1 2
    ATG4D SCOC 0 0 123 158 1 2
    ATG4D CISD2 0 0 143 182 1 2
    ATG4D FBXL15 0 0 0 188 1 1
    ATG4D BRD7 0 0 0 185 1 1
    ATG4D HDAC6 0 0 218 258 1 2
    ATG4D EIF2AK4 0 0 96 150 1 1
    ATG4D CPVL 0 0 0 205 1 1
    ATG4D CD300C 0 0 267 267 1 1
    ATG4D PRKAR2A 0 0 82 165 1 1
    ATG4D MS4A4E 0 0 193 193 1 1
    ATG4D LAMP1 0 0 245 362 1 2
    ATG4D CFLAR 0 0 183 212 1 1
    ATG4D HTT 0 0 103 210 1 1
    ATG4D TP53 0 0 183 183 1 2
    ATG4D TGM2 0 0 95 151 1 1
    ATG4D IRGQ 0 0 0 254 1 1
    ATG4D CNNM2 0 0 0 194 1 1
    ATG4D CTSA 0 0 105 331 1 1
    ATG4D MAP1A 0 0 206 238 1 1
    ATG4D LMF1 0 0 0 204 1 1
    ATG4D BCAS3 0 0 0 287 1 2
    ATG4D CASP10 0 0 165 197 1 1
    ATG4D FBXL16 0 0 0 163 1 1
    ATG4D SRGAP2 0 0 0 186 1 1
    ATG4D STK11 0 0 90 211 1 2
    ATG4D RB1CC1 0 0 421 665 1 2
    ATG4D UBE2H 0 0 0 234 1 1
    ATG4D TM9SF1 0 0 162 322 1 2
    ATG4D LGMN 0 0 0 378 1 1
    ATG4D PARK2 0 0 162 224 1 1
    ATG4D GMNC 0 0 120 186 1 1
    ATG4D TUBA3D 0 0 0 162 1 1
    ATG4D ACP5 0 0 0 271 1 1
    ATG4D ENSG00000261832 0 0 166 218 1 1
    ATG4D EDC4 0 0 0 164 1 1
    ATG4D GLIPR2 0 0 70 153 1 2
    ATG4D AMN1 0 0 0 163 1 1
    ATG4D DVL1 0 0 0 184 1 1
    ATG4D SH3GLB1 0 0 234 250 1 2
    ATG4D BFAR 0 0 123 369 1 1
    ATG4D AIFM2 0 0 102 160 1 1
    ATG4D FNBP1 0 0 85 251 1 1
    ATG4D CAMKK1 0 0 0 168 1 1
    ATG4D CYCS 0 0 181 181 1 1
    ATG4D ATP6V1D 0 0 96 182 1 1
    ATG4D PDE6B 0 0 0 165 1 1
    ATG4D TUBD1 0 0 0 165 1 1
    ATG4D TSR2 0 0 0 242 1 1
    ATG4D TRIM55 192 0 0 211 1 1
    ATG4D FIGN 0 0 0 329 1 1
    ATG4D PITPNC1 0 0 0 150 1 1
    ATG4D KCNH6 0 0 0 183 1 1
    ATG4D CTSH 0 0 113 267 1 1
    ATG4D LPIN3 0 0 0 215 1 1
    ATG4D MAP1S 0 0 96 178 1 2
    ATG4D PPP2CB 0 0 0 172 1 1
    ATG4D KDM2A 0 0 0 163 1 1
    ATG4D IMPDH1 187 0 0 235 1 1
    ATG4D PLD1 0 0 0 164 1 1
    ATG4D TRAPPC10 0 0 94 172 1 1
    ATG4D MIPEP 0 0 96 152 1 1
    ATG4D MAPK8 0 0 203 222 1 2
    ATG4D SIRT6 0 0 112 303 1 1
    ATG4D CAP2 0 0 0 232 1 1
    ATG4D PDE4D 0 0 0 165 1 1
    ATG4D SGK494 0 0 0 227 1 1
    ATG4D ATP2A1 0 0 60 243 1 1
    ATG4D BDH2 0 0 96 410 1 1
    ATG4D MRPS7 0 0 49 259 1 1
    ATG4D TRADD 0 0 123 164 1 1
    ATG4D ATG16L2 0 0 556 662 1 2
    ATG4D PDE4A 0 0 0 165 1 1
    ATG4D REXO2 0 0 0 206 1 1
    ATG4D PITPNM1 0 0 0 150 1 1
    ATG4D CASP7 0 0 140 226 1 1
    ATG4D ONECUT1 0 0 0 178 1 1
    ATG4D DRAM2 0 0 342 353 1 2
    ATG4D GGH 0 0 60 205 1 1
    ATG4D ERO1L 0 0 74 151 1 1
    ATG4D STK35 0 0 0 471 1 1
    ATG4D UTP15 0 0 0 188 1 1
    ATG4D SQSTM1 0 0 466 534 1 2
    ATG4D BNIP3 0 0 376 487 1 2
    ATG4D STK38 0 0 0 210 1 1
    ATG4D ULK4 0 0 150 206 1 1
    ATG4D ABCG1 0 0 0 201 1 1
    ATG4D ATG13 0 0 467 712 1 2
    ATG4D DCTN6 0 0 142 236 1 1
    ATG4D ASS1 0 0 0 303 1 1
    ATG4D PSMA2 0 0 0 190 1 1
    ATG4D HSP90AA1 0 0 143 205 1 2
    ATG4D ATP6V0B 0 0 73 232 1 1
    ATG4D SNX8 0 0 0 186 1 1
    ATG4D ATG9A 0 0 529 767 1 2
    ATG4D ALG6 0 0 0 372 1 1
    ATG4D PCSK4 0 0 0 153 1 1
    ATG4D PRKACB 0 0 0 209 1 1
    ATG4D CSNK1G2 0 0 0 164 1 1
    ATG4D SLC44A2 0 0 0 172 1 1
    ATG4D MFN1 0 0 49 190 1 1
    ATG4D BSN 0 0 0 165 1 2
    ATG4D CTSF 0 0 74 382 1 1
    ATG4D UBXN8 0 0 0 173 1 1
    ATG4D DAPK1 0 0 233 265 1 2
    ATG4D UBA6 0 0 0 205 1 1
    ATG4D TPP1 0 0 0 190 1 1
    ATG4D KIAA0226L 0 0 125 250 1 1
    ATG4D PIK3CG 0 0 107 182 1 1
    ATG4D DGKQ 0 0 0 238 1 1
    ATG4D SRRD 0 0 96 152 1 1
    ATG4D AAMP 0 0 0 160 1 1
    ATG4D AKT1 0 0 166 282 1 2
    ATG4D RAB40C 0 0 134 166 1 1
    ATG4D ENSG00000260272 0 0 0 214 1 1
    ATG4D TUBA3C 0 0 0 162 1 1
    ATG4D UBA5 0 0 68 246 1 1
    ATG4D LRCH1 0 0 0 151 1 1
    ATG4D ATF6 0 0 144 175 1 2
    ATG4D ABCG8 0 0 0 201 1 1
    ATG4D SIRT4 0 0 112 198 1 1
    ATG4D MTX2 0 0 124 206 1 1
    ATG4D SRGAP3 0 0 0 186 1 1
    ATG4D SNX7 0 0 0 186 1 2
    ATG4D MAFK 0 0 96 159 1 1
    ATG4D FBXL17 0 0 0 163 1 1
    ATG4D PCSK9 0 0 0 166 1 1
    ATG4D CUX2 0 0 0 171 1 1
    ATG4D TUBA1C 0 0 0 162 1 1
    ATG4D SMURF2 0 0 0 157 1 1
    ATG4D STAMBP 0 0 0 185 1 1
    ATG4D RABGEF1 0 0 0 220 1 1
    ATG4D TUBB8 0 0 0 199 1 1
    ATG4D UBE2C 0 0 0 156 1 1
    ATG4D ACLY 0 0 0 193 1 1
    ATG4D TUBB8B 0 0 0 199 1 1
    ATG4D WWP2 0 0 61 174 1 1
    ATG4D EIF2AK3 0 0 125 269 1 2
    ATG4D PDE9A 0 0 0 165 1 1
    ATG4D FBXL13 0 0 0 163 1 1
    ATG4D FBXL6 0 0 0 195 1 1
    ATG4D OXR1 0 0 0 257 1 1
    ATG4D STX17 0 0 95 253 1 2
    ATG4D UBA3 0 0 0 205 1 1
    ATG4D TSC2 0 0 142 205 1 2
    ATG4D HECTD1 0 0 181 226 1 1
    ATG4D BNIP3L 0 0 241 270 1 2
    ATG4D CDKN1B 0 0 112 150 1 2
    ATG4D ZFYVE1 0 0 171 233 1 2
    ATG4D CAPN14 0 0 0 189 1 1
    ATG4D GRID1 0 0 167 181 1 2
    ATG4D BAK1 0 0 187 228 1 2
    ATG4D PITPNA 0 0 0 150 1 1
    ATG4D ITSN1 0 0 0 150 1 1
    ATG4D FAF2 0 0 0 173 1 1
    ATG4D ATG2A 0 0 561 764 1 2
    ATG4D STBD1 0 0 261 311 1 2
    ATG4D RPS6KB1 0 0 136 228 1 2
    ATG4D FAM179B 0 0 0 185 1 1
    ATG4D EPG5 0 0 234 492 1 2
    ATG4D ABCG2 0 0 45 204 1 1
    ATG4D ULK3 0 0 90 513 1 2
    ATG4D HERC3 0 0 0 260 1 1
    ATG4D SBNO1 0 0 0 180 1 1
    ATG4D ALDOC 0 0 0 183 1 1
    ATG4D ATG4B 0 0 684 211 1 2
    ATG4D PIK3C2G 0 0 73 150 1 1
    ATG4D ENSG00000267157 0 0 0 228 1 1
    ATG4D RAB7A 0 0 123 301 1 2
    ATG4D DRAM1 0 0 457 542 1 2
    ATG4D TLDC2 0 0 0 257 1 1
    ATG4D TOE1 0 0 52 234 1 1
    ATG4D UVRAG 0 0 422 588 1 2
    ATG4D VPS11 0 0 120 308 1 2
    ATG4D NFYC 0 0 0 163 1 1
    ATG4D C22orf29 0 0 170 169 1 1
    ATG4D NBR1 0 0 295 466 1 2
    ATG4D CHIA 0 0 0 188 1 1
    ATG4D LPIN2 0 0 0 215 1 1
    ATG4D WIPI2 0 0 343 664 1 2
    ATG4D FIS1 0 0 0 153 1 2
    ATG4D ITCH 0 0 45 160 1 1
    ATG4D ENSG00000100926 0 0 163 324 1 1
    ATG4D OPTN 0 0 193 198 1 2
    ATG4D PDE10A 0 0 0 172 1 1
    ATG4D CALCOCO2 0 0 368 381 1 2
    ATG4D MIB1 0 0 0 226 1 1
    ATG4D HS1BP3 0 0 0 164 1 2
    ATG4D ACN9 0 0 123 155 1 1
    ATG4D MAP1LC3B 270 900 468 977 1 2
    ATG4D WDR11 0 0 0 260 1 1
    ATG4D ULK1 0 0 427 746 1 2
    ATG4D HNRNPDL 0 0 0 160 1 1
    ATG4D CECR2 0 0 97 156 1 1
    ATG4D SNX30 0 0 0 186 1 1
    ATG4D DYRK1B 0 0 0 162 1 1
    ATG4D STK40 0 0 0 153 1 1
    ATG4D MAEA 0 0 0 227 1 1
    ATG4D UQCR10 0 0 107 411 1 1
    ATG4D AMBRA1 0 0 517 573 1 2
    ATG4D TSSK6 0 0 0 158 1 1
    ATG4D GOPC 130 0 0 193 1 2
    ATG4D UBA2 0 0 0 234 1 1
    ATG4D CTSS 0 0 166 211 1 1
    ATG4D NYAP2 0 0 0 189 1 1
    ATG4D TUBB6 0 0 0 190 1 1
    ATG4D CASP3 270 0 324 505 1 2
    ATG4D SMURF1 0 0 54 168 1 1
    ATG4D TUBB2B 0 0 0 192 1 1
    ATG4D UQCC2 0 0 104 498 1 1
    ATG4D PLD2 0 0 0 164 1 1
    ATG4D ATG101 0 0 402 655 1 2
    ATG4D DUS4L 0 0 0 288 1 1
    ATG4D LRCH4 0 0 0 151 1 1
    ATG4D TUBA8 0 0 0 162 1 1
    ATG4D FBXO39 0 0 0 163 1 1
    ATG4D ATG16L1 0 0 557 791 1 2
    ATG4D GUSB 0 0 90 165 1 1
    ATG4D CDC34 0 0 0 266 1 1
    ATG4D TUBG1 0 0 0 165 1 1
    ATG4D ONECUT3 0 0 0 178 1 1
    ATG4D DTX2 0 0 0 151 1 1
    ATG4D JMJD6 0 0 0 183 1 1
    ATG4D MLST8 0 0 113 277 1 2
    ATG4D KDM2B 0 0 0 163 1 1
    ATG4D TNIP1 0 0 71 152 1 1
    ATG4D FAF1 0 0 0 173 1 1
    ATG4D LPIN1 0 0 0 215 1 2
    ATG4D TUBG2 0 0 0 165 1 1
    ATG4D TRIP10 0 0 0 186 1 1
    ATG4D DNAJC10 0 0 0 161 1 1
    ATG4D BECN1 0 0 602 862 1 2
    ATG4D FBXL19 0 0 0 211 1 1
    ATG4D SNX4 0 0 90 228 1 1
    ATG4D ALDOA 0 0 0 183 1 1
    ATG4D BCL2L1 0 0 322 336 1 2
    ATG4D TUBB4A 0 0 0 193 1 1
    ATG4D PIK3R4 0 0 401 654 1 2
    ATG4D P4HA2 129 0 0 192 1 1
    ATG4D LONRF2 0 0 0 175 1 1
    ATG4D TSNARE1 0 0 0 163 1 1
    ATG4D GABARAPL2 270 900 601 985 1 2
    ATG4D ATG14 0 0 508 704 1 2
    ATG4D TUBB1 0 0 0 190 1 1
    ATG4D PRKACA 0 0 0 209 1 1
    ATG4D USP43 0 0 0 161 1 1
    ATG4D PDE4C 0 0 0 165 1 1
    ATG4D PDE11A 0 0 0 172 1 1
    ATG4D SH3GLB2 0 0 187 295 1 1
    ATG4D MAST1 0 0 0 249 1 1
    ATG4D CCNC 0 0 60 239 1 1
    ATG4D TMEM184B 0 0 0 164 1 1
    ATG4D CCNF 0 0 60 194 1 1
    ATG4D CLN3 0 0 161 213 1 2
    ATG4D UBE2R2 0 0 0 221 1 1
    ATG4D SIRT5 0 0 103 164 1 1
    ATG4D RAB5B 0 0 72 190 1 1
    ATG4D NAE1 0 0 0 205 1 1
    ATG4D NMT1 0 0 74 313 1 1
    ATG4D SRGAP2C 0 0 0 186 1 1
    ATG4D TMEM184A 0 0 0 164 1 1
    ATG4D MAP1LC3A 0 900 454 982 1 2
    ATG4D PDE7A 0 0 0 165 1 1
    ATG4D CAMKK2 0 0 73 196 1 2
    ATG4D CYBA 0 0 46 228 1 1
    ATG4D HGS 0 0 123 220 1 2
    ATG4D HOOK3 0 0 95 191 1 1
    ATG4D SETD8 0 0 0 231 1 1
    ATG4D RAB9A 0 0 0 188 1 2
    ATG4D EZH2 0 0 85 168 1 1
    ATG4D GMPPA 0 0 0 155 1 1
    ATG4D KCNH7 0 0 0 183 1 1
    ATG4D PLEKHJ1 0 0 286 415 1 1
    ATG4D FADD 0 0 165 179 1 2
    ATG4D MRPL38 0 0 178 196 1 1
    ATG4D TUBA4A 0 0 0 162 1 1
    ATG4D ATP6V0C 0 0 243 514 1 2
    ATG4D HSPBP1 0 0 0 151 1 1
    ATG4D PRKACG 0 0 42 209 1 1
    ATG4D CNNM1 0 0 0 194 1 1
    ATG4D PRKX 0 0 0 209 1 1
    ATG4D SNX14 0 0 113 419 1 1
    ATG4D FBXL3 0 0 0 163 1 1
    ATG4D PPP3CC 0 0 0 266 1 1
    ATG4D UBA1 0 0 45 209 1 1
    ATG4D FURIN 0 0 46 151 1 1
    ATG4D PSMB3 0 0 94 259 1 1
    ATG4D NCOA7 0 0 0 257 1 1
    ATG4D AKT2 0 0 0 154 1 1
    ATG4D RNF214 0 0 0 191 1 1
    ATG4D ENSG00000272772 0 0 0 172 1 1
    ATG4D ENSG00000279576 0 0 154 153 1 1
    ATG4D IRGM 0 0 391 390 1 2
    ATG4D TBC1D24 0 0 0 214 1 1
    ATG4D SBNO2 0 0 0 210 1 1
    ATG4D PPP3CB 0 0 0 266 1 1
    ATG4D TUBA3E 0 0 0 162 1 1
    ATG4D NPC1 0 0 103 180 1 2
    ATG4D SBDS 0 0 54 172 1 1
    ATG4D TMEM59 0 0 153 152 1 1
    ATG4D ITPR1 0 0 202 224 1 2
    ATG4D DUS2 0 0 0 308 1 1
    ATG4D ATG4A 0 0 753 215 1 2
    ATG4D CASP9 0 0 141 212 1 1
    ATG4D ZUFSP 0 0 0 163 1 1
    ATG4D RPTOR 0 0 167 217 1 2
    ATG4D SRGAP1 0 0 0 186 1 1
    ATG4D ATPAF2 0 0 0 349 1 1
    ATG4D PDE2A 0 0 0 172 1 1
    ATG4D RPS6KB2 0 0 75 173 1 2
    ATG4D GRINA 0 0 0 166 1 1
    ATG4D HES5 0 0 0 187 1 1
    ATG4D DAPK3 0 0 92 160 1 2
    ATG4D VPS18 0 0 181 283 1 1
    ATG4D KCTD2 0 0 134 211 1 1
    ATG4D FICD 0 0 0 540 1 1
    ATG4D RAB9B 0 0 0 188 1 1
    ATG4D ELFN2 0 0 166 165 1 1
    ATG4D MAP1LC3C 0 900 505 972 1 2
    ATG4D SPNS2 0 0 0 156 1 1
    ATG4D DNM2 0 0 0 194 1 1
    ATG4D CUX1 0 0 0 171 1 1
    ATG4D SEC22C 0 0 217 266 1 1
    ATG4D HERC4 0 0 0 185 1 1
    ATG4D CASP8 270 0 305 500 1 2
    ATG4D TUBB3 0 0 0 192 1 1
    ATG4D CHRAC1 0 0 0 163 1 1
    ATG4D KEAP1 0 0 108 171 1 2
    ATG4D SIRT3 0 0 96 165 1 2
    ATG4D TFEB 0 0 282 302 1 2
    ATG4D ABCG4 0 0 0 201 1 1
    ATG4D TUBA1B 0 0 0 162 1 1
    ATG4D GABARAPL1 270 900 611 988 1 2
    ATG4D SLC44A4 0 0 0 172 1 1
    ATG4D KCNH2 0 0 0 183 1 1
    ATG4D EIF4G1 0 0 112 194 1 2
    ATG4D RAB24 0 0 459 564 1 2
    ATG4D EI24 0 0 134 228 1 2
    ATG4D SRGAP2B 0 0 0 186 1 1
    ATG4D FUNDC1 0 0 202 219 1 2
    ATG4D SAE1 0 0 0 225 1 1
    ATG4D MIB2 0 0 0 256 1 1
    ATG4D DTX4 0 0 0 151 1 1
    ATG4D MYRF 0 0 90 245 1 1
    ATG4D PVRL2 0 0 48 264 1 1
    ATG4D LAMP2 0 0 243 373 1 2
    ATG4D UBE3C 0 0 0 158 1 1
    ATG4D BORA 0 0 0 187 1 1
    ATG4D SNX1 0 0 0 186 1 1
    ATG4D BCL2L11 0 0 147 180 1 1
    ATG4D TNFSF10 0 0 113 168 1 2
    ATG4D MST4 0 0 155 174 1 1
    ATG4D ULK2 0 0 509 774 1 2
    ATG4D SNCA 0 0 103 202 1 2
    ATG4D MOCS3 0 0 0 205 1 1
    ATG4D DTX1 0 0 0 151 1 1
    ATG4D CASP1 0 0 135 183 1 2
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0004197 Molecular Function cysteine-type endopeptidase activity enables IBA
    GO:0070004 Molecular Function cysteine-type exopeptidase activity enables IDA
    GO:0008234 Molecular Function cysteine-type peptidase activity enables IDA
    GO:0019786 Molecular Function protein-phosphatidylethanolamide deconjugating activity enables IBA
    GO:0035973 Biological Process aggrephagy involved_in IBA
    GO:0006915 Biological Process apoptotic process involved_in IEA
    GO:0000045 Biological Process autophagosome assembly involved_in IBA
    GO:0000045 Biological Process autophagosome assembly involved_in IDA
    GO:0006914 Biological Process autophagy involved_in IDA
    GO:0000423 Biological Process mitophagy involved_in IBA
    GO:0000423 Biological Process mitophagy involved_in IMP
    GO:0034727 Biological Process piecemeal microautophagy of the nucleus involved_in IBA
    GO:0051697 Biological Process protein delipidation involved_in IDA
    GO:0034497 Biological Process protein localization to phagophore assembly site involved_in IMP
    GO:0016485 Biological Process protein processing involved_in IBA
    GO:0015031 Biological Process protein transport involved_in IEA
    GO:0006508 Biological Process proteolysis involved_in IDA
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0005759 Cellular Component mitochondrial matrix located_in IEA
    GO:0005739 Cellular Component mitochondrion located_in IDA
    GO:0005654 Cellular Component nucleoplasm located_in IDA
    Pathways
    Name DB ID
    Macroautophagy Reactome R-HSA-1632852
    Autophagy Reactome R-HSA-9612973
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_104024 2 miscRNA transcript variant 3 NC_000019 Reference
    NR_104025 2 miscRNA transcript variant 4 NC_000019 Reference
    NM_001281504 2 mRNA transcript variant 2 NC_000019 Reference
    NM_032885 6 mRNA transcript variant 1 NC_000019 Reference
    XM_006722927 2 mRNA transcript variant X1 NC_000019 Reference