SESN2

sestrin 2
General Information
Name sestrin 2
Alias
  • sestrin-2
  • hypoxia induced gene 95
  • hypoxia-induced
Synonyms SES2 DKFZp761M0212 HI95 SEST2
Gene_family None
organism Homo sapiens
entrez_id 83667
location 1p35.3
transcript_count 2
exon_count 10
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]
      Stringdb Sestrin-2; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1. May positively regulate the transcripti [...]
      nextProt Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190, PubMed:31586034, PubMed:35114100). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190, PubMed:31586034, PubMed:35114100). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190, PubMed:35114100). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    SESN2 BioGRID YTHDF1 GeneID BioGRID Cross-Linking-MS (XL-MS)
    SESN2 BioGRID RPA2 GeneID BioGRID Proximity Label-MS
    SESN2 BioGRID RPA1 GeneID BioGRID Proximity Label-MS
    SESN2 BioGRID CASTOR1 GeneID BioGRID Affinity Capture-Western
    SESN2 BioGRID WDR24 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    SESN2 BioGRID WDR59 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    SESN2 BioGRID MIOS GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    SESN2 BioGRID CUL4A GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID CRYAA GeneID BioGRID Reconstituted Complex
    SESN2 BioGRID STAMBPL1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    SESN2 BioGRID RNF167 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    SESN2 BioGRID METAP2 GeneID BioGRID Affinity Capture-Western
    SESN2 BioGRID ATG9A GeneID BioGRID Proximity Label-MS
    SESN2 BioGRID N GeneID BioGRID Protein-RNA
    SESN2 BioGRID DHX57 GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID WDR5 GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID SEC13 GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID RBBP5 GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID GYPA GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID EP300 GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    SESN2 BioGRID FASN GeneID BioGRID Negative Genetic
    SESN2 BioGRID RNF186 GeneID BioGRID Reconstituted Complex
    SESN2 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID SZT2 GeneID BioGRID Affinity Capture-Western
    SESN2 BioGRID NPRL2 GeneID BioGRID Affinity Capture-Western
    SESN2 BioGRID NPRL3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    SESN2 BioGRID ULK1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    SESN2 BioGRID DEPDC5 GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID EGFR GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western; Co-localization
    SESN2 BioGRID RB1CC1 GeneID BioGRID Affinity Capture-Western
    SESN2 BioGRID ATG13 GeneID BioGRID Affinity Capture-Western
    SESN2 BioGRID MDM2 GeneID BioGRID Two-hybrid
    SESN2 BioGRID RBX1 GeneID BioGRID Affinity Capture-Western
    SESN2 BioGRID KEAP1 GeneID BioGRID Affinity Capture-Western
    SESN2 BioGRID VCP GeneID BioGRID Affinity Capture-MS
    SESN2 BioGRID PRDX1 GeneID BioGRID Affinity Capture-Western
    SESN2 Protein PRDX1 GeneID HPRD None
    SESN2 Protein None None BIND ATP interacts with Hi95.
    SESN2 Protein None None BIND Mg++ interacts with Hi95.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    SESN2 JUN 0 0 462 462 1 1
    SESN2 DAPK1 0 0 193 193 1 2
    SESN2 WDR5 409 0 0 408 1 1
    SESN2 TSC1 0 0 419 480 1 2
    SESN2 MTHFD2 0 0 218 239 1 1
    SESN2 CCL24 0 0 0 205 1 1
    SESN2 SLC16A4 0 0 161 218 1 1
    SESN2 MAPK12 0 0 0 152 1 1
    SESN2 SPATA18 0 0 164 178 1 1
    SESN2 HSPA1A 0 0 182 193 1 1
    SESN2 ULK2 0 0 431 466 1 2
    SESN2 PADI4 0 0 134 156 1 1
    SESN2 PIK3CG 0 0 58 151 1 1
    SESN2 SNAP29 0 0 134 206 1 2
    SESN2 CHEK1 0 0 181 181 1 1
    SESN2 SLC16A3 0 0 193 237 1 1
    SESN2 NEIL2 0 0 143 180 1 1
    SESN2 SNCA 0 0 137 155 1 2
    SESN2 RLF 0 0 150 159 1 1
    SESN2 AKT1S1 0 0 325 356 1 1
    SESN2 ZC2HC1A 0 0 122 256 1 1
    SESN2 CRK 0 0 322 321 1 1
    SESN2 TFAM 0 0 153 154 1 1
    SESN2 EI24 0 0 181 204 1 2
    SESN2 SEPT5 0 0 414 414 1 1
    SESN2 ATP5B 0 0 56 176 1 1
    SESN2 ENSG00000270024 0 0 0 170 1 1
    SESN2 TCIRG1 0 900 0 902 1 1
    SESN2 IGFBP3 0 0 294 309 1 1
    SESN2 IRS2 0 0 103 164 1 1
    SESN2 DEPDC5 270 600 550 860 1 1
    SESN2 FUNDC1 0 0 218 235 1 2
    SESN2 ARNT 0 0 464 463 1 2
    SESN2 CDC25C 0 0 112 151 1 1
    SESN2 PRDX1 270 600 764 926 1 1
    SESN2 NPRL3 486 600 546 940 1 1
    SESN2 RSPH6A 0 0 0 150 1 1
    SESN2 VCP 113 0 66 159 1 2
    SESN2 LAMP2 0 0 247 260 1 2
    SESN2 RBM12 0 0 134 269 1 1
    SESN2 GABARAPL1 0 0 244 257 1 2
    SESN2 PDK2 0 0 161 211 1 1
    SESN2 CCNB2 0 0 171 199 1 1
    SESN2 ATP6V1E1 0 900 0 900 1 1
    SESN2 SIRT7 0 0 184 183 1 1
    SESN2 ATP6V0B 0 900 0 902 1 1
    SESN2 RAB1A 0 0 135 194 1 2
    SESN2 FAM212B 0 0 308 312 1 1
    SESN2 SLC38A2 0 0 174 191 1 1
    SESN2 CRLF2 0 0 0 208 1 1
    SESN2 EIF4G1 0 0 134 150 1 2
    SESN2 RHOA 0 0 123 287 1 1
    SESN2 HSPA8 0 0 193 203 1 2
    SESN2 CRTC2 0 0 142 163 1 1
    SESN2 GATSL3 0 0 707 743 1 1
    SESN2 CDKN1A 0 0 363 421 1 2
    SESN2 BNIP3 0 0 537 548 1 2
    SESN2 SQSTM1 675 0 393 800 1 2
    SESN2 SLC16A1 0 0 74 174 1 1
    SESN2 PCK2 0 0 209 281 1 1
    SESN2 SIRT3 0 0 172 171 1 2
    SESN2 KEAP1 270 0 936 955 1 2
    SESN2 MAPK3 0 0 182 214 1 2
    SESN2 KLF15 0 0 113 158 1 1
    SESN2 GTSE1 0 0 259 283 1 1
    SESN2 FRG1B 0 0 0 224 1 1
    SESN2 ATP6V1G2 0 900 0 900 1 1
    SESN2 TMEM144 0 0 134 322 1 1
    SESN2 ATG13 270 0 325 509 1 2
    SESN2 INS 0 0 309 309 1 1
    SESN2 ACTB 0 0 341 341 1 1
    SESN2 ASS1 0 0 134 221 1 1
    SESN2 ENSG00000280297 0 0 0 224 1 1
    SESN2 PDCD10 0 0 0 188 1 1
    SESN2 TP73 0 0 211 211 1 2
    SESN2 FRMPD3 0 0 139 198 1 1
    SESN2 HSP90AA1 0 0 154 153 1 2
    SESN2 TFEB 0 0 335 390 1 2
    SESN2 ENSG00000269905 0 0 70 211 1 1
    SESN2 PGK1 0 0 206 206 1 2
    SESN2 RAP2A 0 0 141 184 1 1
    SESN2 EIF4E2 0 0 123 488 1 1
    SESN2 TYROBP 0 0 453 453 1 1
    SESN2 HERPUD1 0 0 145 166 1 1
    SESN2 ALB 0 0 183 183 1 1
    SESN2 CASP8 0 0 204 204 1 2
    SESN2 XPO7 0 0 0 194 1 1
    SESN2 SGK2 0 0 0 170 1 1
    SESN2 SDHA 0 0 74 170 1 1
    SESN2 TP53AIP1 0 0 181 181 1 1
    SESN2 ADCY5 0 0 45 192 1 1
    SESN2 EP300 0 0 252 252 1 1
    SESN2 CDK5 0 0 0 207 1 2
    SESN2 RBM42 0 0 125 259 1 1
    SESN2 IL4 0 0 56 201 1 1
    SESN2 OSGIN1 0 0 74 185 1 1
    SESN2 MIOS 675 800 652 977 1 1
    SESN2 SIRT6 0 0 217 239 1 1
    SESN2 H2AFX 0 0 134 159 1 1
    SESN2 SLC3A2 0 0 386 414 1 1
    SESN2 PLCD4 0 0 74 279 1 1
    SESN2 GATS 0 0 0 159 1 1
    SESN2 RPS6KB2 0 0 72 255 1 2
    SESN2 FKBP1A 0 0 202 202 1 2
    SESN2 TNS1 0 0 77 173 1 1
    SESN2 HSPA6 0 0 107 162 1 1
    SESN2 NDUFS5 0 0 0 156 1 1
    SESN2 UBALD2 0 0 166 193 1 1
    SESN2 GLRX3 0 0 0 185 1 1
    SESN2 ATP6V0D2 0 900 0 917 1 1
    SESN2 BCKDK 0 0 113 565 1 1
    SESN2 BEST3 0 0 73 155 1 1
    SESN2 UPP1 0 0 181 324 1 1
    SESN2 ADIPOQ 0 0 123 177 1 1
    SESN2 BHLHE40 0 0 242 241 1 1
    SESN2 MAPK8 0 0 211 229 1 2
    SESN2 PRKAB1 0 600 466 787 1 2
    SESN2 GCLC 0 0 171 171 1 1
    SESN2 SKP2 0 0 150 187 1 1
    SESN2 IGFBP1 0 0 150 281 1 1
    SESN2 PRKAB2 0 600 253 728 1 1
    SESN2 EGF 0 0 156 155 1 1
    SESN2 FASN 62 0 108 179 1 1
    SESN2 FLCN 0 0 391 503 1 1
    SESN2 CASP9 0 0 150 171 1 1
    SESN2 SESN3 0 800 811 808 1 1
    SESN2 DUSP12 0 0 177 196 1 1
    SESN2 CYCS 0 0 270 270 1 1
    SESN2 PLK2 0 0 201 250 1 1
    SESN2 RPS6KA3 0 0 155 156 1 1
    SESN2 GADD45B 0 0 266 288 1 1
    SESN2 CHEK2 0 0 172 190 1 1
    SESN2 IMMT 0 0 226 225 1 1
    SESN2 MAPK9 0 0 61 157 1 2
    SESN2 RPTOR 0 900 466 951 1 2
    SESN2 PDCD4 0 0 118 222 1 1
    SESN2 ATP6V1D 0 900 0 900 1 1
    SESN2 HIF1AN 0 0 181 181 1 1
    SESN2 PPARA 0 0 150 174 1 1
    SESN2 ENSG00000183628 0 0 322 321 1 1
    SESN2 HMGCL 0 0 58 203 1 1
    SESN2 HSPA4 0 0 163 212 1 1
    SESN2 LPIN3 0 0 0 181 1 1
    SESN2 DYRK3 0 0 95 209 1 1
    SESN2 IGF1R 0 0 91 164 1 1
    SESN2 ATP6V1G3 0 900 0 900 1 1
    SESN2 PPARGC1A 0 0 316 316 1 1
    SESN2 PCK1 0 0 114 178 1 1
    SESN2 HMGCLL1 0 0 108 163 1 1
    SESN2 PDK1 0 0 143 194 1 1
    SESN2 CHMP4C 0 0 66 273 1 1
    SESN2 MYC 0 0 310 325 1 2
    SESN2 APEX1 0 0 146 178 1 1
    SESN2 PARK2 0 0 218 218 1 1
    SESN2 PIK3CA 0 0 47 153 1 2
    SESN2 SLC1A4 0 0 96 205 1 1
    SESN2 TOP1 0 0 98 173 1 1
    SESN2 USP10 0 0 171 171 1 2
    SESN2 GLS 0 0 122 303 1 1
    SESN2 SLC7A1 0 0 122 162 1 1
    SESN2 GPT2 0 0 181 249 1 1
    SESN2 ATP6V1G1 0 900 66 903 1 1
    SESN2 G6PC 0 0 105 202 1 1
    SESN2 RICTOR 0 360 500 689 1 2
    SESN2 PIK3R3 0 0 75 320 1 1
    SESN2 EGLN3 0 0 310 309 1 1
    SESN2 NUPR1 0 0 172 171 1 1
    SESN2 EFNA5 0 0 651 665 1 1
    SESN2 NGDN 0 0 183 184 1 1
    SESN2 ITFG2 0 600 328 732 1 1
    SESN2 SLC2A3 0 0 181 198 1 1
    SESN2 MYCN 0 0 141 162 1 1
    SESN2 TBCB 0 0 0 190 1 1
    SESN2 EIF5B 0 0 342 342 1 1
    SESN2 CHAC1 0 0 469 527 1 1
    SESN2 GP1BB 0 0 430 430 1 1
    SESN2 PHLDA3 0 0 283 303 1 1
    SESN2 BRCA1 0 0 139 165 1 1
    SESN2 STK11 0 0 975 976 1 2
    SESN2 RB1CC1 270 0 470 599 1 2
    SESN2 NFE2L2 0 0 370 370 1 1
    SESN2 AKT2 0 0 91 226 1 1
    SESN2 VWCE 0 0 195 223 1 1
    SESN2 LAMP1 0 0 134 154 1 2
    SESN2 DECR1 0 0 0 187 1 1
    SESN2 RPS28 0 0 0 252 1 1
    SESN2 SLC2A1 0 0 310 325 1 1
    SESN2 FGFR3 0 0 0 151 1 1
    SESN2 HTT 0 0 141 194 1 1
    SESN2 METAP2 0 0 161 197 1 1
    SESN2 EGFR 103 0 181 250 1 1
    SESN2 MDM2 111 0 450 499 1 1
    SESN2 TP53 0 900 679 966 1 2
    SESN2 GMDS 0 0 55 175 1 1
    SESN2 ATP6V0C 0 900 0 900 1 2
    SESN2 SLC7A5 0 0 324 366 1 1
    SESN2 DDIT3 0 0 454 510 1 2
    SESN2 RAB10 0 0 134 152 1 1
    SESN2 POX2 0 0 430 430 1 1
    SESN2 HK2 0 0 167 167 1 1
    SESN2 TSPAN31 0 0 83 204 1 1
    SESN2 ALDH1L2 0 0 181 246 1 1
    SESN2 NR4A1 0 0 263 279 1 1
    SESN2 NPRL2 270 600 470 900 1 1
    SESN2 JAK2 0 0 74 181 1 1
    SESN2 SNX22 0 0 107 201 1 1
    SESN2 NUFIP2 0 0 0 208 1 1
    SESN2 APAF1 0 0 157 164 1 1
    SESN2 ZNF184 0 0 107 182 1 1
    SESN2 EIF2AK4 0 0 457 511 1 1
    SESN2 CD300C 0 0 181 181 1 1
    SESN2 C7orf60 0 0 401 461 1 1
    SESN2 ATP6V0D1 0 900 0 910 1 1
    SESN2 STAT3 0 0 157 156 1 2
    SESN2 ERN1 0 0 195 209 1 2
    SESN2 LAMTOR4 0 900 294 926 1 1
    SESN2 PRKAR2A 0 360 0 360 1 1
    SESN2 GCLM 0 0 206 206 1 1
    SESN2 NDRG1 0 0 166 165 1 1
    SESN2 PIR 0 0 180 352 1 1
    SESN2 MAPK13 0 0 64 173 1 1
    SESN2 ZNF74 0 0 306 313 1 1
    SESN2 FAM193A 0 0 178 325 1 1
    SESN2 SLC1A7 0 0 298 307 1 1
    SESN2 HIF1A 0 0 606 606 1 2
    SESN2 ATP6V1H 0 900 0 900 1 1
    SESN2 SH3BP4 0 0 450 462 1 1
    SESN2 SIRT5 0 0 170 169 1 1
    SESN2 NXPE2 0 0 151 183 1 1
    SESN2 HIF3A 0 0 572 572 1 1
    SESN2 SP1 0 0 144 153 1 1
    SESN2 MCCC1 0 0 59 205 1 1
    SESN2 PSAT1 0 0 212 348 1 1
    SESN2 RHOBTB1 0 0 0 165 1 1
    SESN2 KCTD5 0 0 0 157 1 1
    SESN2 PRKAG1 0 600 112 648 1 1
    SESN2 CACNA2D2 0 0 649 649 1 1
    SESN2 IGSF9B 0 0 107 201 1 1
    SESN2 TMEM132E 0 0 150 240 1 1
    SESN2 AMIGO2 0 0 55 200 1 1
    SESN2 CTNNB1 0 0 163 183 1 1
    SESN2 ATP6V1B1 0 900 0 900 1 1
    SESN2 HRAS 0 0 152 209 1 1
    SESN2 MAP1LC3A 0 0 123 217 1 2
    SESN2 RANBP17 0 0 0 199 1 1
    SESN2 EPHA2 0 0 66 178 1 1
    SESN2 EGR1 0 0 181 190 1 1
    SESN2 MTOR 0 900 603 960 1 2
    SESN2 MAPKAP1 0 360 202 521 1 1
    SESN2 CARS 0 0 74 161 1 1
    SESN2 E2F2 0 0 357 357 1 1
    SESN2 ATP6V0E2 0 900 0 900 1 1
    SESN2 SCO2 0 0 337 364 1 1
    SESN2 GATSL2 0 0 459 526 1 1
    SESN2 DNAJB4 0 0 0 159 1 1
    SESN2 SYVN1 0 0 113 174 1 1
    SESN2 RPS6 0 0 261 274 1 1
    SESN2 ALDH3B1 0 0 120 158 1 1
    SESN2 PIK3C3 0 0 321 340 1 2
    SESN2 UCP2 0 0 212 212 1 1
    SESN2 IL6 0 0 157 156 1 1
    SESN2 KIAA0247 0 0 152 202 1 1
    SESN2 C1orf43 0 0 107 166 1 1
    SESN2 CREB1 0 0 171 171 1 1
    SESN2 ESRRA 0 0 0 188 1 1
    SESN2 GRB10 0 0 134 186 1 1
    SESN2 SDHB 0 0 120 273 1 1
    SESN2 PRKACA 0 360 0 360 1 1
    SESN2 TENC1 0 0 0 200 1 1
    SESN2 PFKFB3 0 0 246 255 1 1
    SESN2 DGCR8 0 0 389 388 1 1
    SESN2 RHOBTB2 0 0 95 264 1 1
    SESN2 ARF1 0 0 233 274 1 1
    SESN2 EPHX4 0 0 94 169 1 1
    SESN2 PRDX5 0 0 620 620 1 1
    SESN2 C12orf66 0 600 360 757 1 1
    SESN2 LY6G5B 0 0 103 177 1 1
    SESN2 SIRT2 0 0 170 169 1 2
    SESN2 MRPL34 0 0 66 150 1 1
    SESN2 EPO 0 0 244 243 1 1
    SESN2 PLK1 0 0 98 193 1 1
    SESN2 SIAH1 0 0 156 155 1 1
    SESN2 ATF5 0 0 207 361 1 1
    SESN2 NOL4 0 0 81 178 1 1
    SESN2 FGF21 0 0 202 202 1 1
    SESN2 CCDC23 0 0 125 210 1 1
    SESN2 ANXA5 0 0 233 234 1 1
    SESN2 CCNB1 0 0 210 210 1 1
    SESN2 SLC38A9 0 0 624 649 1 1
    SESN2 LAMTOR5 0 900 231 924 1 1
    SESN2 PERP 0 0 181 243 1 1
    SESN2 GPATCH4 0 0 0 186 1 1
    SESN2 APOM 0 0 55 213 1 1
    SESN2 PRODH 0 0 415 414 1 1
    SESN2 BCL2L1 0 0 228 227 1 2
    SESN2 PIK3R4 0 0 202 221 1 2
    SESN2 CACNA1G 0 0 0 208 1 1
    SESN2 ALDH1A2 0 0 414 414 1 1
    SESN2 DMGDH 0 0 72 170 1 1
    SESN2 ATP6V1C2 0 900 72 905 1 1
    SESN2 FKBP8 0 0 142 163 1 1
    SESN2 GPR3 0 0 56 313 1 1
    SESN2 GABARAPL2 0 0 212 221 1 2
    SESN2 PRR5 0 360 269 523 1 1
    SESN2 SLC38A5 0 0 193 193 1 1
    SESN2 ENSG00000273748 0 0 181 337 1 1
    SESN2 KSR2 0 0 0 157 1 1
    SESN2 KLHL24 0 0 163 173 1 1
    SESN2 GAPDH 0 0 348 347 1 2
    SESN2 TRIAP1 0 0 155 213 1 1
    SESN2 ATG14 0 0 254 274 1 2
    SESN2 LARS2 0 0 508 590 1 1
    SESN2 LPIN1 0 0 280 398 1 2
    SESN2 DGCR2 0 0 306 306 1 1
    SESN2 DNAJB9 0 0 138 209 1 2
    SESN2 RRAGD 0 900 518 955 1 1
    SESN2 AUH 0 0 72 175 1 1
    SESN2 PMAIP1 0 0 402 402 1 1
    SESN2 RPL23A 0 0 143 233 1 1
    SESN2 DUSP1 0 0 173 196 1 1
    SESN2 PPM1A 0 0 325 325 1 1
    SESN2 LRRK2 270 0 66 301 1 2
    SESN2 ABCB1 0 0 72 214 1 1
    SESN2 NUAK2 0 0 70 154 1 1
    SESN2 BECN1 0 0 395 405 1 2
    SESN2 ATP6V0E1 0 900 0 902 1 1
    SESN2 EIF4EBP2 0 0 87 227 1 1
    SESN2 EPAS1 0 0 386 386 1 2
    SESN2 FOXO1 0 0 294 308 1 2
    SESN2 KRAS 0 0 134 215 1 1
    SESN2 TAS1R3 0 0 96 158 1 1
    SESN2 MECR 0 0 88 180 1 1
    SESN2 SOD2 0 0 277 304 1 1
    SESN2 RND2 0 0 66 161 1 1
    SESN2 PGM2 0 0 95 341 1 1
    SESN2 HSPA5 0 0 194 194 1 2
    SESN2 TFE3 0 0 150 189 1 1
    SESN2 ITFG1 0 0 112 152 1 1
    SESN2 FKBP10 0 0 60 159 1 1
    SESN2 CAMK4 0 0 108 263 1 1
    SESN2 MLST8 0 900 390 936 1 2
    SESN2 ANGPTL4 0 0 166 165 1 1
    SESN2 DEPTOR 0 0 392 442 1 1
    SESN2 CRKL 0 0 389 388 1 1
    SESN2 RRAGC 0 900 692 971 1 1
    SESN2 PRKAR1A 0 360 0 360 1 2
    SESN2 WDR59 675 800 562 977 1 1
    SESN2 GSC2 0 0 538 538 1 1
    SESN2 LAMTOR1 0 900 364 933 1 1
    SESN2 PHB2 0 0 134 188 1 1
    SESN2 HIGD1A 0 0 469 469 1 1
    SESN2 AKAP1 0 0 453 453 1 1
    SESN2 ABCB4 0 0 0 188 1 1
    SESN2 RRM2 0 0 216 246 1 1
    SESN2 DGCR6 0 0 322 321 1 1
    SESN2 CEBPB 0 0 241 265 1 1
    SESN2 TBC1D7 0 0 325 338 1 2
    SESN2 TXNRD1 0 0 167 167 1 1
    SESN2 ATG16L1 0 0 181 200 1 2
    SESN2 ATP6V1C1 0 900 0 900 1 1
    SESN2 CUL3 0 0 171 191 1 1
    SESN2 PDE3B 0 0 0 189 1 1
    SESN2 CDKN2A 0 0 195 195 1 2
    SESN2 CCNG1 0 0 279 366 1 1
    SESN2 PNISR 0 0 92 157 1 1
    SESN2 ATP6V1E2 0 900 0 900 1 1
    SESN2 EDA2R 0 0 244 462 1 1
    SESN2 PRR5L 0 360 45 362 1 1
    SESN2 GPR137B 0 0 140 273 1 1
    SESN2 GPR6 0 0 0 248 1 1
    SESN2 ATG12 0 0 280 283 1 2
    SESN2 TNFRSF10B 0 0 244 262 1 1
    SESN2 EIF4B 0 0 141 182 1 1
    SESN2 ATP6V1B2 0 900 0 900 1 1
    SESN2 CDH16 0 0 60 156 1 1
    SESN2 KAT8 0 0 74 170 1 2
    SESN2 ZFAND3 0 0 0 166 1 1
    SESN2 RAB4B 0 0 66 181 1 1
    SESN2 CASP3 0 0 306 306 1 2
    SESN2 NQO1 0 0 241 240 1 1
    SESN2 EGLN1 0 0 260 260 1 1
    SESN2 TRIB3 0 0 459 510 1 1
    SESN2 RNF152 0 0 230 240 1 1
    SESN2 NLRP3 0 0 210 210 1 2
    SESN2 ATG101 0 0 218 237 1 2
    SESN2 VEGFA 0 0 394 394 1 1
    SESN2 SLC2A14 0 0 162 180 1 1
    SESN2 GABARAP 0 0 150 181 1 2
    SESN2 PTEN 0 0 369 468 1 2
    SESN2 DNM1L 0 0 150 185 1 2
    SESN2 RRAGB 0 900 566 966 1 2
    SESN2 PRKAA2 0 600 155 712 1 2
    SESN2 TELO2 0 360 0 382 1 1
    SESN2 LDHA 0 0 249 248 1 1
    SESN2 LOC110117498-PIK3R3 0 0 0 217 1 1
    SESN2 AMBRA1 0 0 244 260 1 2
    SESN2 C12orf5 0 0 520 539 1 1
    SESN2 NFKBIA 0 0 134 171 1 1
    SESN2 TXNDC2 0 0 96 158 1 1
    SESN2 KAT5 0 0 73 217 1 2
    SESN2 RCHY1 0 0 163 181 1 1
    SESN2 SREBF1 0 0 254 315 1 2
    SESN2 C17orf107 0 0 249 248 1 1
    SESN2 UCP1 0 0 142 201 1 1
    SESN2 SLC36A4 0 0 242 289 1 1
    SESN2 MROH2B 0 0 172 398 1 1
    SESN2 ADARB1 0 0 45 259 1 1
    SESN2 PON2 0 0 122 215 1 1
    SESN2 SHC1 0 0 66 182 1 1
    SESN2 ATM 0 0 342 342 1 1
    SESN2 PRKAG3 0 600 0 610 1 1
    SESN2 DAP 0 0 143 175 1 2
    SESN2 G6PD 0 0 157 184 1 1
    SESN2 TTI1 0 360 134 459 1 1
    SESN2 MDM4 0 0 177 235 1 1
    SESN2 EGLN2 0 0 252 252 1 1
    SESN2 ATG7 0 0 358 384 1 2
    SESN2 BTG2 0 0 256 269 1 1
    SESN2 GDF15 0 0 294 330 1 1
    SESN2 MS4A5 0 0 174 297 1 1
    SESN2 TAF6L 0 0 108 196 1 1
    SESN2 DBH 0 0 0 208 1 1
    SESN2 CPT1C 0 0 111 151 1 1
    SESN2 FGFR4 0 0 0 208 1 1
    SESN2 ABCC10 0 0 82 177 1 1
    SESN2 PPARGC1B 0 0 93 288 1 1
    SESN2 ZC3H14 0 0 82 425 1 1
    SESN2 NPC1L1 0 0 92 184 1 1
    SESN2 ATG10 0 0 215 216 1 2
    SESN2 CDC45 0 0 357 373 1 1
    SESN2 RANBP1 0 0 434 434 1 1
    SESN2 HIGD2A 0 0 321 321 1 1
    SESN2 MAP1LC3B 0 0 282 303 1 2
    SESN2 KPTN 0 600 345 751 1 1
    SESN2 TTC19 0 0 94 158 1 1
    SESN2 SARS 0 0 98 235 1 1
    SESN2 AQP9 0 0 61 205 1 1
    SESN2 RPS6KA1 0 0 195 214 1 1
    SESN2 ALDH4A1 0 0 376 455 1 1
    SESN2 ULK1 486 0 661 835 1 2
    SESN2 PLK3 0 0 171 239 1 1
    SESN2 FNIP1 0 0 217 234 1 1
    SESN2 GPX1 0 0 391 403 1 1
    SESN2 AKT3 0 0 70 208 1 1
    SESN2 NOX1 0 0 161 162 1 1
    SESN2 BAI1 0 0 161 161 1 1
    SESN2 SIRT1 0 0 296 296 1 2
    SESN2 DDIT4L 0 0 212 240 1 1
    SESN2 PGM2L1 0 0 0 216 1 1
    SESN2 MCL1 0 0 167 185 1 2
    SESN2 OPTN 0 0 150 168 1 2
    SESN2 ESR1 0 0 142 160 1 1
    SESN2 TXNDC5 0 0 205 269 1 1
    SESN2 LAPTM5 0 0 87 152 1 1
    SESN2 CALCOCO2 0 0 170 169 1 2
    SESN2 ATG5 0 0 370 394 1 2
    SESN2 XBP1 0 0 294 299 1 2
    SESN2 PANK1 0 0 134 168 1 1
    SESN2 GNB1L 0 0 485 486 1 1
    SESN2 PRKAG2 0 600 72 627 1 1
    SESN2 LARS 0 0 518 600 1 1
    SESN2 LTBP4 0 0 203 203 1 1
    SESN2 NBR1 0 0 204 231 1 2
    SESN2 PRDM5 0 0 0 151 1 1
    SESN2 TNF 0 0 195 195 1 1
    SESN2 QSER1 0 0 117 352 1 1
    SESN2 ARNT2 0 0 242 241 1 1
    SESN2 LPIN2 0 0 0 181 1 1
    SESN2 AEN 0 0 203 226 1 1
    SESN2 SLC1A5 0 0 193 283 1 1
    SESN2 HOXA3 0 0 323 323 1 1
    SESN2 KIAA0141 0 0 158 181 1 1
    SESN2 GLS2 0 0 322 461 1 1
    SESN2 ERCC3 0 0 48 172 1 1
    SESN2 EEF2 0 0 123 180 1 1
    SESN2 FNIP2 0 0 194 212 1 1
    SESN2 PPP1R15A 0 0 219 244 1 2
    SESN2 SLC7A11 0 0 280 280 1 1
    SESN2 LAMTOR3 0 900 247 921 1 1
    SESN2 ACER2 0 0 181 181 1 1
    SESN2 ATG4B 0 0 143 174 1 2
    SESN2 ACMSD 0 0 67 281 1 1
    SESN2 RPS6KA2 0 0 150 156 1 1
    SESN2 ASB11 0 0 113 184 1 1
    SESN2 TXNIP 0 0 261 287 1 1
    SESN2 LAMTOR2 0 900 236 927 1 1
    SESN2 PLEKHA4 270 0 0 270 1 1
    SESN2 TAS1R2 0 0 58 217 1 1
    SESN2 DRAM1 0 0 530 544 1 2
    SESN2 RAB7A 0 0 150 181 1 2
    SESN2 ATF3 0 0 369 387 1 1
    SESN2 GADD45A 0 0 454 516 1 1
    SESN2 DP2 0 0 70 211 1 1
    SESN2 PFKFB4 0 0 180 190 1 1
    SESN2 UVRAG 0 0 278 278 1 2
    SESN2 IGF1 0 0 215 221 1 1
    SESN2 PRKDC 0 0 123 185 1 2
    SESN2 SERPINE1 0 0 171 171 1 1
    SESN2 AHR 0 0 150 243 1 1
    SESN2 GAMT 0 0 205 350 1 1
    SESN2 EIF4E 0 0 724 733 1 1
    SESN2 DGCR6L 0 0 310 309 1 1
    SESN2 CDK1 0 0 130 202 1 1
    SESN2 TXNRD3NB 0 0 269 269 1 1
    SESN2 KAT2B 0 0 62 206 1 1
    SESN2 RPS6KB1 0 0 502 600 1 2
    SESN2 FDXR 0 0 291 359 1 1
    SESN2 LOX 0 0 171 171 1 1
    SESN2 RRAD 0 0 96 197 1 1
    SESN2 IRS1 0 0 151 166 1 1
    SESN2 SGK1 0 0 141 256 1 1
    SESN2 SESN1 0 800 857 808 1 2
    SESN2 NTRK1 0 0 124 288 1 1
    SESN2 ATR 0 0 90 152 1 1
    SESN2 RNF186 270 0 90 313 1 1
    SESN2 ABCB5 0 0 96 459 1 1
    SESN2 ATP6V1F 0 900 0 900 1 1
    SESN2 RRM2B 0 0 334 348 1 1
    SESN2 NOS3 0 0 164 163 1 1
    SESN2 ANKRD37 0 0 193 193 1 1
    SESN2 CCND1 0 0 226 242 1 1
    SESN2 PRKAA1 0 600 173 700 1 2
    SESN2 AQP3 0 0 57 161 1 1
    SESN2 RPRM 0 0 135 222 1 1
    SESN2 DDB2 0 0 257 258 1 1
    SESN2 SZT2 270 600 293 793 1 1
    SESN2 APOBR 0 0 81 332 1 1
    SESN2 TP53I3 0 0 367 434 1 1
    SESN2 AARS 0 0 74 284 1 1
    SESN2 HPRT1 0 0 123 155 1 1
    SESN2 BCAT2 0 0 245 292 1 1
    SESN2 RHEB 0 900 517 962 1 2
    SESN2 DDIT4 0 0 567 593 1 1
    SESN2 MAP4K3 0 0 157 210 1 1
    SESN2 TXN 0 0 282 285 1 1
    SESN2 PDPK1 0 0 140 161 1 2
    SESN2 TBX1 0 0 350 349 1 1
    SESN2 CAT 0 0 285 301 1 1
    SESN2 DNAJC17 0 0 210 570 1 1
    SESN2 SEC13 279 800 340 910 1 1
    SESN2 TCHP 0 0 257 256 1 1
    SESN2 HMOX1 0 0 325 341 1 2
    SESN2 MTFP1 0 0 124 214 1 1
    SESN2 LAPTM4B 0 0 170 203 1 1
    SESN2 FRG1 0 0 172 330 1 1
    SESN2 RRAGA 0 900 602 969 1 2
    SESN2 EIF2S1 0 0 261 368 1 2
    SESN2 NDUFA1 0 0 0 156 1 1
    SESN2 GADD45G 0 0 290 291 1 1
    SESN2 RBX1 486 0 242 593 1 1
    SESN2 PPM1D 0 0 341 399 1 1
    SESN2 TSC2 0 0 731 803 1 2
    SESN2 BNIP3L 0 0 318 332 1 2
    SESN2 CDKN1B 0 0 123 156 1 2
    SESN2 PSMF1 0 0 0 188 1 1
    SESN2 SLC2A4 0 0 180 197 1 1
    SESN2 FOXO3 0 0 324 482 1 2
    SESN2 CRIP2 0 0 60 222 1 1
    SESN2 SHISA5 0 0 232 252 1 1
    SESN2 WDR24 835 800 696 992 1 1
    SESN2 ATG4C 0 0 145 168 1 2
    SESN2 SRC 0 0 124 161 1 1
    SESN2 CKAP2 0 0 122 216 1 1
    SESN2 VHL 0 0 287 286 1 1
    SESN2 ATG3 0 0 240 239 1 2
    SESN2 DNAJB1 0 0 122 182 1 2
    SESN2 CDKN3 0 0 202 219 1 1
    SESN2 TP53INP1 0 0 370 396 1 2
    SESN2 PTPRM 0 0 53 153 1 1
    SESN2 ACLY 0 0 134 173 1 1
    SESN2 SRXN1 0 0 393 432 1 1
    SESN2 FOXJ2 0 0 57 202 1 1
    SESN2 EIF2AK3 0 0 293 293 1 2
    SESN2 SIRT4 0 0 184 183 1 1
    SESN2 BIRC5 0 0 77 177 1 2
    SESN2 PINK1 0 0 240 239 1 2
    SESN2 CHRD 0 0 398 398 1 1
    SESN2 TAS1R1 0 0 114 263 1 1
    SESN2 PHGDH 0 0 123 274 1 1
    SESN2 CDC16 0 0 123 165 1 1
    SESN2 WWOX 0 0 48 156 1 1
    SESN2 CCNG2 0 0 246 308 1 1
    SESN2 RNF103 0 0 75 197 1 1
    SESN2 RHOC 0 0 0 162 1 1
    SESN2 EIF4EBP1 0 0 427 462 1 1
    SESN2 ASPG 0 0 147 278 1 1
    SESN2 GAS2 0 0 108 267 1 1
    SESN2 SEH1L 0 800 425 893 1 1
    SESN2 P4HA1 0 0 359 359 1 1
    SESN2 KRR1 0 0 0 188 1 1
    SESN2 TOP1MT 0 0 138 224 1 1
    SESN2 STC2 0 0 224 282 1 1
    SESN2 ATP6V1A 0 900 57 901 1 1
    SESN2 FOXQ1 0 0 44 336 1 1
    SESN2 BBC3 0 0 358 402 1 1
    SESN2 BCAT1 0 0 95 151 1 1
    SESN2 CADM2 0 0 46 193 1 1
    SESN2 PRDX3 0 0 218 231 1 1
    SESN2 CES5A 0 0 97 252 1 1
    SESN2 ZMAT3 0 0 263 326 1 1
    SESN2 PPARG 0 0 171 189 1 1
    SESN2 AKT1 0 0 459 539 1 2
    SESN2 GARS 0 0 108 239 1 1
    SESN2 CA9 0 0 395 394 1 1
    SESN2 ATF4 0 0 391 397 1 2
    SESN2 MXD1 0 0 74 171 1 1
    SESN2 SGK3 0 0 0 170 1 1
    SESN2 ATF6 0 0 267 267 1 2
    SESN2 SLC36A1 0 0 162 168 1 1
    SESN2 AARS2 0 0 0 213 1 1
    SESN2 PSPH 0 0 150 344 1 1
    SESN2 ASNS 0 0 415 523 1 1
    SESN2 XIAP 0 0 164 216 1 1
    SESN2 CEBPG 0 0 166 238 1 1
    SESN2 GMFG 0 0 73 173 1 1
    SESN2 NOX4 0 0 204 204 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005092 Molecular Function GDP-dissociation inhibitor activity enables IEA
    GO:0070728 Molecular Function L-leucine binding enables IBA
    GO:0070728 Molecular Function L-leucine binding enables IDA
    GO:0042731 Molecular Function PH domain binding enables IEA
    GO:0016684 Molecular Function oxidoreductase activity, acting on peroxide as acceptor enables IBA
    GO:0004601 Molecular Function peroxidase activity enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0140311 Molecular Function protein sequestering activity enables IDA
    GO:0044877 Molecular Function protein-containing complex binding NOT enables IPI
    GO:0044877 Molecular Function protein-containing complex binding enables IPI
    GO:0032542 Molecular Function sulfiredoxin activity NOT enables IDA
    GO:0032542 Molecular Function sulfiredoxin activity enables IDA
    GO:0046323 Biological Process D-glucose import involved_in IEA
    GO:0030330 Biological Process DNA damage response, signal transduction by p53 class mediator involved_in IMP
    GO:0098869 Biological Process cellular oxidant detoxification NOT involved_in IDA
    GO:0098869 Biological Process cellular oxidant detoxification involved_in IDA
    GO:0098869 Biological Process cellular oxidant detoxification involved_in IMP
    GO:0071233 Biological Process cellular response to L-leucine involved_in IBA
    GO:0071233 Biological Process cellular response to L-leucine involved_in IDA
    GO:0071233 Biological Process cellular response to L-leucine involved_in IMP
    GO:0034198 Biological Process cellular response to amino acid starvation involved_in IMP
    GO:0071230 Biological Process cellular response to amino acid stimulus involved_in IMP
    GO:0042149 Biological Process cellular response to glucose starvation involved_in IMP
    GO:1990253 Biological Process cellular response to leucine starvation involved_in IBA
    GO:1990253 Biological Process cellular response to leucine starvation involved_in IDA
    GO:1990253 Biological Process cellular response to leucine starvation involved_in IMP
    GO:0034599 Biological Process cellular response to oxidative stress involved_in ISS
    GO:0006635 Biological Process fatty acid beta-oxidation involved_in IEA
    GO:0042593 Biological Process glucose homeostasis involved_in IEA
    GO:0032042 Biological Process mitochondrial DNA metabolic process involved_in IEA
    GO:1904262 Biological Process negative regulation of TORC1 signaling involved_in IBA
    GO:1904262 Biological Process negative regulation of TORC1 signaling involved_in IDA
    GO:1904262 Biological Process negative regulation of TORC1 signaling involved_in IMP
    GO:0030308 Biological Process negative regulation of cell growth involved_in ISS
    GO:1902010 Biological Process negative regulation of translation in response to endoplasmic reticulum stress involved_in IMP
    GO:1904263 Biological Process positive regulation of TORC1 signaling involved_in IDA
    GO:1904504 Biological Process positive regulation of lipophagy involved_in IEA
    GO:0016239 Biological Process positive regulation of macroautophagy involved_in IBA
    GO:0016239 Biological Process positive regulation of macroautophagy involved_in IMP
    GO:0051897 Biological Process positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in IEA
    GO:1900182 Biological Process positive regulation of protein localization to nucleus involved_in IMP
    GO:0072593 Biological Process reactive oxygen species metabolic process involved_in IDA
    GO:0072593 Biological Process reactive oxygen species metabolic process involved_in IMP
    GO:1903432 Biological Process regulation of TORC1 signaling involved_in IDA
    GO:0141161 Biological Process regulation of cAMP/PKA signal transduction involved_in IEA
    GO:0006111 Biological Process regulation of gluconeogenesis involved_in IEA
    GO:0001932 Biological Process regulation of protein phosphorylation involved_in IDA
    GO:1901031 Biological Process regulation of response to reactive oxygen species involved_in IEA
    GO:0009749 Biological Process response to glucose involved_in IEA
    GO:0032868 Biological Process response to insulin involved_in IEA
    GO:0070328 Biological Process triglyceride homeostasis involved_in IEA
    GO:1990316 Cellular Component Atg1/ULK1 kinase complex part_of IPI
    GO:0031932 Cellular Component TORC2 complex part_of ISS
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0005765 Cellular Component lysosomal membrane is_active_in IDA
    GO:0005739 Cellular Component mitochondrion located_in IEA
    GO:0031588 Cellular Component nucleotide-activated protein kinase complex part_of ISS
    GO:0005634 Cellular Component nucleus located_in IEA
    Pathways
    Name DB ID
    Generic Transcription Pathway Reactome R-HSA-212436
    Cellular responses to stress Reactome R-HSA-2262752
    Transcriptional Regulation by TP53 Reactome R-HSA-3700989
    TP53 Regulates Metabolic Genes Reactome R-HSA-5628897
    RNA Polymerase II Transcription Reactome R-HSA-73857
    Gene expression (Transcription) Reactome R-HSA-74160
    Cellular responses to stimuli Reactome R-HSA-8953897
    Amino acids regulate mTORC1 Reactome R-HSA-9639288
    Cellular response to starvation Reactome R-HSA-9711097
    Cellular response to chemical stress Reactome R-HSA-9711123
    KEAP1-NFE2L2 pathway Reactome R-HSA-9755511
    p53 transcriptional gene network (WP4963) WikiPathways WP4963_r122690
    Head and neck squamous cell carcinoma (WP4674) WikiPathways WP4674_r123494
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_031459 5 mRNA None NC_000001 Reference
    XM_047431519 1 mRNA transcript variant X1 NC_000001 Reference