C19orf12

chromosome 19 open reading frame 12
General Information
Name chromosome 19 open reading frame 12
Alias
  • protein C19orf12
  • membrane protein-associated neurodegeneration
  • neurodegeneration with brain iron accumulation 3
Synonyms MGC10922 DKFZP762D096 NBIA4 MPAN NBIA3 SPG43
Gene_family None
organism Homo sapiens
entrez_id 83636
location 19q12
transcript_count 11
exon_count 7
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a small transmembrane protein. Mutations in this gene are a cause of neurodegeneration with brain iron accumulation-4 (NBIA4), but the specific function of the encoded protein is unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
      Stringdb Protein C19orf12; Chromosome 19 open reading frame 12
      nextProt None
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    C19orf12 BioGRID APP GeneID BioGRID Reconstituted Complex
    C19orf12 BioGRID IKBKG GeneID BioGRID Reconstituted Complex
    StringDB
    A B experiments database textmining combined score hadb nhadb
    C19orf12 FMR1 0 0 134 227 1 1
    C19orf12 KIAA1919 0 0 68 563 1 1
    C19orf12 ARSI 0 0 380 424 1 1
    C19orf12 MAPT 0 0 172 171 1 2
    C19orf12 FAM91A1 0 0 264 264 1 1
    C19orf12 GOLGA7 0 0 229 228 1 1
    C19orf12 SLC16A2 0 0 258 274 1 1
    C19orf12 AP4S1 0 0 391 432 1 1
    C19orf12 ZFYVE26 0 0 401 405 1 1
    C19orf12 SNCA 0 0 284 284 1 2
    C19orf12 TMEM154 0 0 250 250 1 1
    C19orf12 CYP7B1 0 0 302 318 1 1
    C19orf12 SDC1 0 0 0 207 1 1
    C19orf12 AP4M1 0 0 370 370 1 1
    C19orf12 GTF2H4 0 0 46 541 1 1
    C19orf12 ZFYVE27 0 0 390 431 1 1
    C19orf12 LRRK2 0 0 151 150 1 2
    C19orf12 MTFMT 0 0 181 181 1 1
    C19orf12 ATP13A2 0 0 666 666 1 2
    C19orf12 SLC33A1 0 0 379 392 1 1
    C19orf12 ERLIN2 0 0 452 458 1 1
    C19orf12 TRAM1L1 0 0 0 196 1 1
    C19orf12 WDR45B 0 0 0 189 1 1
    C19orf12 ALDH18A1 0 0 200 200 1 1
    C19orf12 ELOVL4 0 0 113 269 1 1
    C19orf12 ZNF536 0 0 366 366 1 1
    C19orf12 PNPLA6 0 0 470 478 1 1
    C19orf12 SLC40A1 0 0 162 161 1 1
    C19orf12 PARK2 0 0 183 183 1 1
    C19orf12 ETHE1 0 0 164 163 1 1
    C19orf12 CHCHD10 0 0 150 290 1 1
    C19orf12 C7orf55 0 0 261 261 1 1
    C19orf12 SLC41A1 0 0 156 341 1 1
    C19orf12 TECPR2 0 0 459 473 1 2
    C19orf12 SIGMAR1 0 0 243 319 1 1
    C19orf12 TMEM173 0 0 0 303 1 1
    C19orf12 C10orf12 0 0 0 190 1 1
    C19orf12 VARS2 0 0 91 462 1 1
    C19orf12 FA2H 0 0 759 767 1 1
    C19orf12 SFTA2 0 0 95 188 1 1
    C19orf12 VCP 0 0 136 209 1 2
    C19orf12 C2orf69 0 0 264 264 1 1
    C19orf12 PPHLN1 0 0 218 218 1 1
    C19orf12 RTN1 0 0 0 248 1 1
    C19orf12 LIPF 0 0 160 159 1 1
    C19orf12 ALG11 0 0 190 190 1 1
    C19orf12 WDR45 0 0 710 762 1 2
    C19orf12 TM9SF3 0 0 227 226 1 1
    C19orf12 RTN2 0 0 392 480 1 1
    C19orf12 B4GALNT1 0 0 299 339 1 1
    C19orf12 PPCDC 0 0 213 213 1 1
    C19orf12 EID1 0 0 50 195 1 1
    C19orf12 LSG1 0 0 0 187 1 1
    C19orf12 NDUFAF4 0 0 167 167 1 1
    C19orf12 ARIH1 0 0 134 357 1 1
    C19orf12 DEFA6 0 0 0 210 1 1
    C19orf12 FTH1 0 0 181 181 1 1
    C19orf12 SSU72 0 0 152 489 1 1
    C19orf12 RPP21 0 0 73 507 1 1
    C19orf12 SAMD8 0 0 244 243 1 1
    C19orf12 TSHZ3 0 0 155 154 1 1
    C19orf12 JPH3 0 0 184 183 1 1
    C19orf12 C9orf72 0 0 208 214 1 2
    C19orf12 NPIPB4 0 0 154 153 1 1
    C19orf12 UTP14C 0 0 253 252 1 1
    C19orf12 DNAJC13 0 0 214 214 1 1
    C19orf12 TREM2 0 0 71 236 1 1
    C19orf12 TFR2 0 0 234 234 1 1
    C19orf12 UBD 0 0 90 304 1 1
    C19orf12 C5orf63 0 0 323 323 1 1
    C19orf12 ERLIN1 0 0 164 345 1 1
    C19orf12 PYCR2 0 0 184 183 1 1
    C19orf12 WFDC2 0 0 0 156 1 1
    C19orf12 MECR 0 0 210 210 1 1
    C19orf12 PKN2 0 0 0 189 1 1
    C19orf12 RAB39B 0 0 213 213 1 2
    C19orf12 KIAA1161 0 0 277 277 1 1
    C19orf12 PGAP1 0 0 325 336 1 1
    C19orf12 BASP1 0 0 0 299 1 1
    C19orf12 ZNF746 0 0 180 179 1 1
    C19orf12 DDHD2 0 0 373 421 1 1
    C19orf12 IER3IP1 0 0 209 209 1 1
    C19orf12 C6orf136 0 0 0 190 1 1
    C19orf12 GUSB 0 0 52 322 1 1
    C19orf12 IPPK 0 0 261 294 1 1
    C19orf12 AP5Z1 0 0 381 425 1 1
    C19orf12 TMEM126B 0 0 216 216 1 1
    C19orf12 RNF170 0 0 203 203 1 1
    C19orf12 PLP1 0 0 217 231 1 1
    C19orf12 FAM133B 0 0 323 323 1 1
    C19orf12 MAP1A 0 0 59 201 1 1
    C19orf12 GRAMD4 0 0 205 205 1 1
    C19orf12 DEFA1B 0 0 71 158 1 1
    C19orf12 KIF1C 0 0 298 377 1 1
    C19orf12 PLA2G1B 0 0 243 242 1 1
    C19orf12 C8orf82 0 0 455 455 1 1
    C19orf12 TMEM168 0 0 134 225 1 1
    C19orf12 WDR48 0 0 270 378 1 1
    C19orf12 NRM 0 0 90 567 1 1
    C19orf12 STARD3 0 0 123 283 1 1
    C19orf12 CLNS1A 0 0 180 321 1 1
    C19orf12 CSGALNACT2 0 0 193 684 1 1
    C19orf12 ACAD8 0 0 181 181 1 1
    C19orf12 PRPS2 0 0 157 400 1 1
    C19orf12 CYP2U1 0 0 294 346 1 1
    C19orf12 KANK1 0 0 138 271 1 1
    C19orf12 PSMD3 0 0 122 270 1 1
    C19orf12 KRTAP3-3 0 0 269 400 1 1
    C19orf12 SLC25A14 0 0 0 189 1 1
    C19orf12 MFSD6 0 0 245 699 1 1
    C19orf12 CHCHD2 0 0 95 244 1 1
    C19orf12 C8orf46 0 0 112 474 1 1
    C19orf12 SPG11 0 0 517 547 1 1
    C19orf12 GATAD1 0 0 211 211 1 1
    C19orf12 SPG20 0 0 293 365 1 1
    C19orf12 PLA2G6 0 0 720 816 1 1
    C19orf12 KIF5A 0 0 369 369 1 1
    C19orf12 PNPLA2 0 0 161 161 1 1
    C19orf12 SGPP2 0 0 170 169 1 1
    C19orf12 THAP8 0 0 373 373 1 1
    C19orf12 KLC2 0 0 170 169 1 1
    C19orf12 PANK3 0 0 230 278 1 1
    C19orf12 NDUFAF5 0 0 181 181 1 1
    C19orf12 KRTAP3-2 0 0 0 214 1 1
    C19orf12 PPP1R11 0 0 74 396 1 1
    C19orf12 COPS8 0 0 142 516 1 1
    C19orf12 CCNE1 0 0 270 270 1 1
    C19orf12 ARID3A 0 0 0 248 1 1
    C19orf12 SLC19A3 0 0 155 154 1 1
    C19orf12 DEFA1 0 0 67 154 1 1
    C19orf12 NT5C2 0 0 210 250 1 1
    C19orf12 SNTB1 0 0 157 156 1 1
    C19orf12 C7orf60 0 0 73 175 1 1
    C19orf12 UPK3B 0 0 0 189 1 1
    C19orf12 VPS13A 0 0 248 248 1 1
    C19orf12 KIAA0196 0 0 392 397 1 1
    C19orf12 REEP4 0 0 90 152 1 1
    C19orf12 ALKBH6 0 0 248 248 1 1
    C19orf12 BPIFB2 0 0 233 232 1 1
    C19orf12 ATP6V1G2 0 0 167 167 1 1
    C19orf12 HOOK3 0 0 156 155 1 1
    C19orf12 SPG7 0 0 320 347 1 1
    C19orf12 MIEN1 0 0 170 314 1 1
    C19orf12 SLC7A6 0 0 134 404 1 1
    C19orf12 CIZ1 0 0 218 218 1 1
    C19orf12 TECPR1 0 0 66 442 1 2
    C19orf12 REEP2 0 0 407 419 1 1
    C19orf12 TRAM1 0 0 96 465 1 1
    C19orf12 SACS 0 0 251 250 1 1
    C19orf12 FLRT1 0 0 184 342 1 1
    C19orf12 GBA 0 0 202 219 1 1
    C19orf12 MFN2 0 0 67 170 1 2
    C19orf12 PITPNB 0 0 205 205 1 1
    C19orf12 TCF19 0 0 97 359 1 1
    C19orf12 ASPHD2 0 0 281 281 1 1
    C19orf12 NDUFA9 0 0 90 163 1 1
    C19orf12 ACY1 0 0 163 172 1 1
    C19orf12 TRIM39-RPP21 0 0 74 206 1 1
    C19orf12 GBA2 0 0 459 473 1 1
    C19orf12 HFE 0 0 194 194 1 1
    C19orf12 KLC3 0 0 156 155 1 1
    C19orf12 ARID3B 0 0 0 151 1 1
    C19orf12 PANK4 0 0 203 252 1 1
    C19orf12 PPM1D 0 0 74 167 1 1
    C19orf12 FAM73B 0 0 0 410 1 1
    C19orf12 CCT5 0 0 219 254 1 1
    C19orf12 KIF16B 0 0 0 152 1 1
    C19orf12 LCOR 0 0 0 331 1 1
    C19orf12 FTSJ3 0 0 194 194 1 1
    C19orf12 HEPACAM2 0 0 211 211 1 1
    C19orf12 DDHD1 0 0 426 430 1 1
    C19orf12 SLC7A7 0 0 0 340 1 1
    C19orf12 AP4B1 0 0 429 455 1 1
    C19orf12 ACOT9 0 0 215 215 1 1
    C19orf12 WIPI1 0 0 165 165 1 2
    C19orf12 PANK2 0 0 803 837 1 1
    C19orf12 SLC52A3 0 0 218 218 1 1
    C19orf12 AMPD2 0 0 294 294 1 1
    C19orf12 CSGALNACT1 0 0 0 303 1 1
    C19orf12 POP4 0 0 561 767 1 1
    C19orf12 FTL 0 0 633 633 1 1
    C19orf12 TYROBP 0 0 102 242 1 1
    C19orf12 MCCD1 0 0 134 329 1 1
    C19orf12 EGFL6 0 0 0 189 1 1
    C19orf12 OXER1 0 0 210 210 1 1
    C19orf12 SMARCE1 0 0 95 203 1 1
    C19orf12 ATL1 0 0 265 265 1 1
    C19orf12 ARL6IP1 0 0 413 449 1 1
    C19orf12 MATR3 0 0 96 187 1 1
    C19orf12 FAM26F 0 0 229 228 1 1
    C19orf12 CLIP3 0 0 208 208 1 1
    C19orf12 ATP6V0A1 0 0 155 154 1 1
    C19orf12 RTN3 0 0 0 181 1 1
    C19orf12 MRPL19 0 0 154 153 1 1
    C19orf12 PRPS1 0 0 0 317 1 1
    C19orf12 COASY 0 0 619 619 1 1
    C19orf12 PGAP3 0 0 95 159 1 1
    C19orf12 SPAST 0 0 405 405 1 1
    C19orf12 PAPLN 0 0 170 169 1 1
    C19orf12 UTP14A 0 0 193 193 1 1
    C19orf12 C14orf159 0 0 310 309 1 1
    C19orf12 CP 0 0 400 400 1 1
    C19orf12 AMD1 0 0 0 303 1 1
    C19orf12 RAB3GAP2 0 0 181 321 1 1
    C19orf12 ENTPD1 0 0 140 179 1 1
    C19orf12 GABRA6 0 0 47 192 1 1
    C19orf12 TRIM26 0 0 54 218 1 1
    C19orf12 FAM73A 0 0 265 705 1 1
    C19orf12 MFSD6L 0 0 0 355 1 1
    C19orf12 USP8 0 0 187 237 1 1
    C19orf12 OPA3 0 0 164 163 1 1
    C19orf12 SLFN12L 0 0 181 181 1 1
    C19orf12 CDSN 0 0 0 208 1 1
    C19orf12 DENND5B 0 0 253 423 1 1
    C19orf12 DENND5A 0 0 79 289 1 1
    C19orf12 SLC25A32 0 0 205 205 1 1
    C19orf12 TAOK3 0 0 160 159 1 1
    C19orf12 ATP7B 0 0 235 353 1 1
    C19orf12 ENSG00000250232 0 0 735 783 1 1
    C19orf12 TMEM126A 0 0 229 228 1 1
    C19orf12 SEC61G 0 0 167 293 1 1
    C19orf12 IBA57 0 0 306 306 1 1
    C19orf12 REEP1 0 0 340 406 1 1
    C19orf12 IKBKG 178 0 0 177 1 1
    C19orf12 PLEKHF1 0 0 561 561 1 2
    C19orf12 URI1 0 0 561 561 1 1
    C19orf12 CASC3 0 0 134 283 1 1
    C19orf12 GIF 0 0 156 155 1 1
    C19orf12 SPG21 0 0 406 406 1 1
    C19orf12 PPP1R14A 0 0 184 183 1 1
    C19orf12 TRIP12 0 0 134 398 1 1
    C19orf12 TRAM2 0 0 0 196 1 1
    C19orf12 ATP1A3 0 0 194 194 1 1
    C19orf12 GJC2 0 0 260 260 1 1
    C19orf12 GKN2 0 0 180 179 1 1
    C19orf12 EP400NL 0 0 209 209 1 1
    C19orf12 DEFA4 0 0 96 255 1 1
    C19orf12 RBM48 0 0 342 342 1 1
    C19orf12 DCAF17 0 0 738 738 1 1
    C19orf12 C15orf40 0 0 455 455 1 1
    C19orf12 VSTM2B 0 0 457 660 1 1
    C19orf12 RTN4 0 0 84 264 1 1
    C19orf12 BSCL2 0 0 368 380 1 1
    C19orf12 DHX16 0 0 53 311 1 1
    C19orf12 PINK1 0 0 163 163 1 2
    C19orf12 VPS37A 0 0 400 441 1 1
    C19orf12 TRIP4 0 0 231 230 1 1
    C19orf12 SLC12A6 0 0 181 192 1 1
    C19orf12 GTF3C6 0 0 113 584 1 1
    C19orf12 BICD2 0 0 210 210 1 1
    C19orf12 ZFR 0 0 267 292 1 1
    C19orf12 LCORL 0 0 157 598 1 1
    C19orf12 PANK1 0 0 292 336 1 1
    C19orf12 ABCF1 0 0 44 305 1 1
    C19orf12 PRPS1L1 0 0 0 317 1 1
    C19orf12 C12orf65 0 0 525 525 1 1
    C19orf12 AP4E1 0 0 407 444 1 1
    C19orf12 ZNF281 0 0 162 161 1 1
    C19orf12 KIAA1033 0 0 171 171 1 1
    C19orf12 NSUN2 0 0 45 249 1 1
    C19orf12 RPF2 0 0 74 566 1 1
    C19orf12 IER3 0 0 54 199 1 1
    C19orf12 KIF1A 0 0 204 280 1 1
    C19orf12 FBXO7 0 0 246 245 1 2
    C19orf12 ATP7A 0 0 0 189 1 1
    C19orf12 NIPA1 0 0 370 370 1 1
    C19orf12 VARS 0 0 95 341 1 1
    C19orf12 APOL3 0 0 170 169 1 1
    C19orf12 LSM12 0 0 218 371 1 1
    C19orf12 GTPBP2 0 0 341 341 1 1
    C19orf12 AFG3L2 0 0 233 347 1 1
    C19orf12 GNL1 0 0 66 476 1 1
    C19orf12 ALS2 0 0 294 352 1 1
    C19orf12 NDUFA12 0 0 151 150 1 1
    C19orf12 CNOT7 0 0 142 275 1 1
    C19orf12 TUBB 0 0 0 237 1 1
    C19orf12 UQCRFS1 0 0 413 412 1 1
    C19orf12 UBQLN2 0 0 180 194 1 2
    C19orf12 REPS1 0 0 366 366 1 1
    C19orf12 CLEC4F 0 0 164 182 1 1
    C19orf12 SLFN5 0 0 193 193 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0006915 Biological Process apoptotic process involved_in IMP
    GO:0006914 Biological Process autophagy involved_in IMP
    GO:0051560 Biological Process mitochondrial calcium ion homeostasis involved_in IMP
    GO:0006979 Biological Process response to oxidative stress involved_in IMP
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005783 Cellular Component endoplasmic reticulum located_in IDA
    GO:0031966 Cellular Component mitochondrial membrane located_in IDA
    GO:0005739 Cellular Component mitochondrion located_in HTP
    GO:0005739 Cellular Component mitochondrion located_in IDA
    Pathways
    Name DB ID
    Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway (WP4577) WikiPathways WP4577_r123500
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001282929 1 mRNA transcript variant 5 NC_000019 Reference
    XM_047439496 1 mRNA transcript variant X2 NC_000019 Reference
    XM_024451735 2 mRNA transcript variant X3 NC_000019 Reference
    XM_024451734 2 mRNA transcript variant X1 NC_000019 Reference
    XM_047439497 1 mRNA transcript variant X4 NC_000019 Reference
    NM_001256047 2 mRNA transcript variant 4 NC_000019 Reference
    NM_001282930 3 mRNA transcript variant 6 NC_000019 Reference
    NM_001256046 3 mRNA transcript variant 3 NC_000019 Reference
    NM_031448 6 mRNA transcript variant 2 NC_000019 Reference
    NM_001282931 3 mRNA transcript variant 7 NC_000019 Reference
    NM_001031726 4 mRNA transcript variant 1 NC_000019 Reference