RUBCNL

rubicon like autophagy enhancer
General Information
Name rubicon like autophagy enhancer
Alias
  • protein associated with UVRAG as autophagy enhancer
  • KIAA0226 like
  • RUN and cysteine rich domain containing beclin 1 interacting protein like
  • protein RUBCNL-like
  • protein Rubicon-like
  • rubicon like autophagy regulator
Synonyms FLJ21562 PACER C13orf18 KIAA0226L
Gene_family PIK3C3 complex subunits
organism Homo sapiens
entrez_id 80183
location 13q14.13
transcript_count 8
exon_count 17
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a role in endocytic trafficking and autophagy. In cervical cancer cell lines, this gene is expressed at low levels and may function as a tumor suppressor. Promoter hypermethylation of this gene is observed in cervical cancer cell lines and tissue derived from human patients. [provided by RefSeq, Mar 2017]
      nextProt Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    RUBCNL BioGRID UVRAG GeneID BioGRID Affinity Capture-MS
    RUBCNL BioGRID RUFY1 GeneID BioGRID Affinity Capture-MS
    RUBCNL BioGRID PIK3R4 GeneID BioGRID Affinity Capture-MS
    RUBCNL BioGRID SEC23B GeneID BioGRID Affinity Capture-MS
    RUBCNL BioGRID CERT1 GeneID BioGRID Affinity Capture-MS
    RUBCNL BioGRID BECN1 GeneID BioGRID Affinity Capture-MS
    RUBCNL BioGRID PIK3C3 GeneID BioGRID Affinity Capture-MS
    RUBCNL BioGRID GRK6 GeneID BioGRID Affinity Capture-MS
    RUBCNL BioGRID SEC24A GeneID BioGRID Affinity Capture-MS
    RUBCNL BioGRID ERRFI1 GeneID BioGRID Two-hybrid
    RUBCNL BioGRID ZDHHC17 GeneID BioGRID Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    KIAA0226L BECN1 281 0 466 644 2 1
    KIAA0226L ATG101 0 0 117 214 2 1
    KIAA0226L ATG4D 0 0 125 250 2 1
    KIAA0226L DAPK2 0 0 142 218 2 1
    KIAA0226L WIPI1 0 0 112 249 2 1
    KIAA0226L GABARAP 0 0 95 234 2 1
    KIAA0226L TBC1D14 0 0 242 420 2 1
    KIAA0226L ULK1 0 0 108 219 2 1
    KIAA0226L UVRAG 408 0 442 714 2 1
    KIAA0226L WDR45 0 0 155 161 2 1
    KIAA0226L RAB7A 0 0 112 264 2 1
    KIAA0226L DRAM1 0 0 108 245 2 1
    KIAA0226L WIPI2 0 0 0 190 2 1
    KIAA0226L TECPR1 0 0 260 273 2 1
    KIAA0226L ULK3 0 0 164 206 2 1
    KIAA0226L EPG5 0 0 229 291 2 1
    KIAA0226L TP53INP2 0 0 166 192 2 1
    KIAA0226L STX8 0 0 0 181 2 1
    KIAA0226L TP53INP1 0 0 75 151 2 1
    KIAA0226L STX17 0 0 143 259 2 1
    KIAA0226L DAPK1 0 0 247 296 2 1
    KIAA0226L MUL1 0 0 218 218 2 1
    KIAA0226L SQSTM1 0 0 89 195 2 1
    KIAA0226L RAB24 0 0 0 259 2 1
    KIAA0226L GABARAPL1 0 0 56 201 2 1
    KIAA0226L ATG16L2 0 0 161 204 2 1
    KIAA0226L SEC23B 179 0 0 194 2 1
    KIAA0226L ATG4A 0 0 142 214 2 1
    KIAA0226L TM9SF1 0 0 0 199 2 1
    KIAA0226L RAB9A 0 0 0 151 2 1
    KIAA0226L PIK3C3 183 0 179 306 2 1
    KIAA0226L PRKCB 0 0 134 176 2 1
    KIAA0226L ATG14 0 0 129 208 2 1
    KIAA0226L GABARAPL2 0 0 57 156 2 1
    KIAA0226L PIK3R4 129 0 101 251 2 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:1901981 Molecular Function phosphatidylinositol phosphate binding enables IBA
    GO:0032266 Molecular Function phosphatidylinositol-3-phosphate binding enables IDA
    GO:0070273 Molecular Function phosphatidylinositol-4-phosphate binding enables IDA
    GO:0010314 Molecular Function phosphatidylinositol-5-phosphate binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0097352 Biological Process autophagosome maturation involved_in IBA
    GO:0097352 Biological Process autophagosome maturation involved_in IDA
    GO:0061910 Biological Process autophagosome-endosome fusion involved_in IBA
    GO:0061910 Biological Process autophagosome-endosome fusion involved_in IDA
    GO:0061909 Biological Process autophagosome-lysosome fusion involved_in IBA
    GO:0061909 Biological Process autophagosome-lysosome fusion involved_in IDA
    GO:0006629 Biological Process lipid metabolic process involved_in IEA
    GO:0070873 Biological Process regulation of glycogen metabolic process involved_in ISS
    GO:0019216 Biological Process regulation of lipid metabolic process involved_in ISS
    GO:0000421 Cellular Component autophagosome membrane is_active_in IBA
    GO:0000421 Cellular Component autophagosome membrane located_in IDA
    GO:0031410 Cellular Component cytoplasmic vesicle located_in IEA
    GO:0043231 Cellular Component intracellular membrane-bounded organelle is_active_in IBA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001286766 3 mRNA transcript variant 7 NC_000013 Reference
    NM_001286765 3 mRNA transcript variant 6 NC_000013 Reference
    NM_025113 5 mRNA transcript variant 1 NC_000013 Reference
    NM_001286761 2 mRNA transcript variant 2 NC_000013 Reference
    NM_001286764 3 mRNA transcript variant 5 NC_000013 Reference
    NM_001286762 3 mRNA transcript variant 3 NC_000013 Reference
    NM_001349772 2 mRNA transcript variant 8 NC_000013 Reference
    NM_001286763 3 mRNA transcript variant 4 NC_000013 Reference