TSC2

TSC complex subunit 2
General Information
Name TSC complex subunit 2
Alias
  • tuberin
  • protein phosphatase 1, regulatory subunit 160
  • tuberous sclerosis 2 protein
Synonyms tuberin LAM PPP1R160 TSC4
Gene_family TSC complex|Armadillo like helical domain containing|Protein phosphatase 1 regulatory subunits
organism Homo sapiens
entrez_id 7249
location 16p13.3
transcript_count 52
exon_count 45
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis. [provided by RefSeq, May 2022]
      Stringdb Tuberin; In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5; Armadillo-like helical domain containing
      nextProt In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400, PubMed:35772404). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    TSC2 BioGRID E6 GeneID BioGRID Reconstituted Complex; Two-hybrid
    TSC2 BioGRID PLK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    TSC2 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID C9orf72 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID HUWE1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID MEN1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID ARRDC2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID BTG3 GeneID BioGRID Two-hybrid
    TSC2 BioGRID CLEC16A GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
    TSC2 BioGRID TSC1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization; Two-hybrid
    TSC2 BioGRID PJA2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
    TSC2 BioGRID RHOB GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID YWHAQ GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Proximity Label-MS; Reconstituted Complex
    TSC2 BioGRID YWHAZ GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Proximity Label-MS; Reconstituted Complex; Two-hybrid
    TSC2 BioGRID YWHAH GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    TSC2 BioGRID YWHAG GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    TSC2 BioGRID YWHAE GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    TSC2 BioGRID YWHAB GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Proximity Label-MS; Reconstituted Complex; Two-hybrid
    TSC2 BioGRID SFN GeneID BioGRID Proximity Label-MS
    TSC2 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID PLEKHM1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID CCNF GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID CDK1 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID CCNB1 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID CCNA2 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID STK11 GeneID BioGRID Negative Genetic
    TSC2 BioGRID PPP1CA GeneID BioGRID Reconstituted Complex
    TSC2 BioGRID RAB7A GeneID BioGRID Proximity Label-MS
    TSC2 BioGRID P4HA3 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID TMEM9 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID OPALIN GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID CIAO2A GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID TSPAN10 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID DUSP16 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID CYB5B GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID MUL1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID DNAI2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID COL20A1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID PPP4R1L GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID OCIAD1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID SEMA4C GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID TBC1D7 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    TSC2 BioGRID C3orf18 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID TMED5 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID NPTN GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID EEF1AKMT3 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID GPR182 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID PRKCSH GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID MPL GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID GYPA GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID GPR17 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID EFNB1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID CD79B GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID MORF4L1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID HCST GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID CD226 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID DGCR2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID CD83 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID ZP2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID RP2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID FAM221B GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID SIGLECL1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID PHLDB1 GeneID BioGRID Two-hybrid
    TSC2 BioGRID USPL1 GeneID BioGRID Two-hybrid
    TSC2 BioGRID PICK1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    TSC2 BioGRID RPL4 GeneID BioGRID Two-hybrid
    TSC2 BioGRID SEPTIN4 GeneID BioGRID Two-hybrid
    TSC2 BioGRID SERPINI1 GeneID BioGRID Two-hybrid
    TSC2 BioGRID RPSA GeneID BioGRID Two-hybrid
    TSC2 BioGRID GAPDH GeneID BioGRID Two-hybrid
    TSC2 BioGRID EEF1A1 GeneID BioGRID Two-hybrid
    TSC2 BioGRID ACTN2 GeneID BioGRID Two-hybrid
    TSC2 BioGRID MRPL21 GeneID BioGRID Two-hybrid
    TSC2 BioGRID ANKRD35 GeneID BioGRID Two-hybrid
    TSC2 BioGRID SSC4D GeneID BioGRID Two-hybrid
    TSC2 BioGRID SLC13A3 GeneID BioGRID Two-hybrid
    TSC2 BioGRID MKRN1 GeneID BioGRID Two-hybrid
    TSC2 BioGRID LAMTOR1 GeneID BioGRID Proximity Label-MS
    TSC2 BioGRID LAMP3 GeneID BioGRID Proximity Label-MS
    TSC2 BioGRID NUP155 GeneID BioGRID Proximity Label-MS
    TSC2 BioGRID RAB9A GeneID BioGRID Proximity Label-MS
    TSC2 BioGRID LAMP2 GeneID BioGRID Proximity Label-MS
    TSC2 BioGRID EGFR GeneID BioGRID Positive Genetic
    TSC2 BioGRID TRIM63 GeneID BioGRID Two-hybrid
    TSC2 BioGRID TRIM55 GeneID BioGRID Two-hybrid
    TSC2 BioGRID SREBF1 GeneID BioGRID Negative Genetic
    TSC2 BioGRID FASN GeneID BioGRID Negative Genetic
    TSC2 BioGRID HAX1 GeneID BioGRID Proximity Label-MS
    TSC2 BioGRID CBFB GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID OTULIN GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID LMBR1L GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID TBK1 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID DYRK1A GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID TNFSF13B GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID APEX1 GeneID BioGRID Affinity Capture-RNA
    TSC2 BioGRID RHEB GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    TSC2 BioGRID PRKAA1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    TSC2 BioGRID CTDP1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID PLK2 GeneID BioGRID Reconstituted Complex
    TSC2 BioGRID SUPT6H GeneID BioGRID Reconstituted Complex
    TSC2 BioGRID PTPN11 GeneID BioGRID Reconstituted Complex
    TSC2 BioGRID RICTOR GeneID BioGRID Positive Genetic
    TSC2 BioGRID TRAPPC13 GeneID BioGRID Negative Genetic
    TSC2 BioGRID SAR1A GeneID BioGRID Positive Genetic
    TSC2 BioGRID HDAC8 GeneID BioGRID Negative Genetic
    TSC2 BioGRID CAND1 GeneID BioGRID Positive Genetic
    TSC2 BioGRID SLC39A9 GeneID BioGRID Positive Genetic
    TSC2 BioGRID VPS53 GeneID BioGRID Positive Genetic
    TSC2 BioGRID TRAPPC2L GeneID BioGRID Negative Genetic
    TSC2 BioGRID UBE2J1 GeneID BioGRID Negative Genetic
    TSC2 BioGRID TRAPPC12 GeneID BioGRID Positive Genetic
    TSC2 BioGRID RABGEF1 GeneID BioGRID Positive Genetic
    TSC2 BioGRID MTF2 GeneID BioGRID Positive Genetic
    TSC2 BioGRID SEC23IP GeneID BioGRID Positive Genetic
    TSC2 BioGRID SEC24A GeneID BioGRID Negative Genetic
    TSC2 BioGRID B3GNT2 GeneID BioGRID Negative Genetic
    TSC2 BioGRID IGF2BP1 GeneID BioGRID Positive Genetic
    TSC2 BioGRID CARM1 GeneID BioGRID Positive Genetic
    TSC2 BioGRID ARIH2 GeneID BioGRID Negative Genetic
    TSC2 BioGRID DCAF7 GeneID BioGRID Positive Genetic
    TSC2 BioGRID SEC24C GeneID BioGRID Positive Genetic
    TSC2 BioGRID SLC39A7 GeneID BioGRID Positive Genetic
    TSC2 BioGRID TRAPPC2 GeneID BioGRID Positive Genetic
    TSC2 BioGRID RAB1A GeneID BioGRID Positive Genetic
    TSC2 BioGRID IGF1R GeneID BioGRID Positive Genetic
    TSC2 BioGRID B4GALT1 GeneID BioGRID Negative Genetic
    TSC2 BioGRID BMI1 GeneID BioGRID Negative Genetic
    TSC2 BioGRID ARF1 GeneID BioGRID Negative Genetic
    TSC2 BioGRID AKT1 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID RNF123 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID CBL GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID PIH1D1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID RIPK4 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID CCNT1 GeneID BioGRID Synthetic Growth Defect
    TSC2 BioGRID RNGTT GeneID BioGRID Synthetic Growth Defect
    TSC2 BioGRID CDK11A GeneID BioGRID Synthetic Growth Defect
    TSC2 BioGRID TSC2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID DNAAF10 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID RUVBL2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID CBY1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID P4HA2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID PNKD GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID POU5F1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID RRAGA GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID Tbc1d7 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID Tsc1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID RRAGC GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID RRAGD GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID SPINT2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID RRAGB GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID NTRK1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID ALDH3A2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID SIRT1 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID DAPK1 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID MDFI GeneID BioGRID Two-hybrid
    TSC2 BioGRID CBY2 GeneID BioGRID Two-hybrid
    TSC2 BioGRID CIAO1 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID FBXW5 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID HECW2 GeneID BioGRID Affinity Capture-MS
    TSC2 BioGRID SMAD3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TSC2 BioGRID SMAD2 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID CDKN1B GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID ESR1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TSC2 BioGRID CALM1 GeneID BioGRID Far Western; Protein-peptide; Reconstituted Complex
    TSC2 BioGRID PPP1CA GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID TIGAR GeneID BioGRID Co-fractionation
    TSC2 BioGRID NEK1 GeneID BioGRID Two-hybrid
    TSC2 BioGRID LNX1 GeneID BioGRID Two-hybrid
    TSC2 BioGRID HERC1 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID TK1 GeneID BioGRID Two-hybrid
    TSC2 BioGRID PIN1 GeneID BioGRID Two-hybrid
    TSC2 BioGRID GRB2 GeneID BioGRID Two-hybrid
    TSC2 Protein MAPKAPK2 GeneID HPRD None
    TSC2 Protein PPP2CA GeneID HPRD None
    TSC2 Protein NEK1 GeneID HPRD None
    TSC2 Protein YWHAG GeneID HPRD None
    TSC2 Protein TSC1 GeneID HPRD None
    TSC2 Protein YWHAE GeneID HPRD None
    TSC2 Protein RABEP1 GeneID HPRD None
    TSC2 Protein SMAD3 GeneID HPRD None
    TSC2 Protein MAPK3 GeneID HPRD None
    TSC2 Protein RPS6KA1 GeneID HPRD None
    TSC2 Protein SMAD2 GeneID HPRD None
    TSC2 Protein RHEB GeneID HPRD None
    TSC2 Protein SFN GeneID HPRD None
    TSC2 Protein YWHAB GeneID HPRD None
    TSC2 Protein YWHAZ GeneID HPRD None
    TSC2 Protein CDKN1B GeneID HPRD None
    TSC2 Protein RAB5A GeneID HPRD None
    TSC2 Protein MAPK1 GeneID HPRD None
    TSC2 Protein PAM GeneID HPRD None
    TSC2 Protein CCND1 GeneID HPRD None
    TSC2 Protein AKT1 GeneID HPRD None
    TSC2 Protein YWHAQ GeneID HPRD None
    TSC2 Protein ESR1 GeneID HPRD None
    TSC2 Protein YWHAH GeneID HPRD None
    TSC2 BioGRID UBE3A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TSC2 BioGRID PAM GeneID BioGRID Affinity Capture-Western; Co-localization; Two-hybrid
    TSC2 BioGRID GSK3B GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    TSC2 BioGRID FOXO1 GeneID BioGRID Affinity Capture-Western; Co-localization; Reconstituted Complex
    TSC2 BioGRID CCND3 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID CCND2 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID CAV1 GeneID BioGRID Co-purification
    TSC2 BioGRID CCND1 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID AXIN1 GeneID BioGRID Affinity Capture-Western
    TSC2 BioGRID RPS6KA1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TSC2 BioGRID RAP1A GeneID BioGRID Affinity Capture-Western; Co-purification
    TSC2 BioGRID RAB5A GeneID BioGRID Co-purification
    TSC2 BioGRID PTK2 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TSC2 BioGRID MAPK1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TSC2 BioGRID RALA GeneID BioGRID Affinity Capture-Western
    TSC2 Protein RHEB GeneID BIND TSC2 interacts with Rheb.
    TSC2 None None None BIND Erk2 interacts with TSC2. This interaction was modelled on a demonstrated interaction between Erk2 from an unspecified species and human TSC2.
    TSC2 Protein NEK1 GeneID BIND NEK1 interacts with Tuberin.
    TSC2 Protein AKT1 GeneID BIND Akt interacts with and phosphorylates tuberin. This interaction was modelled on a demonstrated interaction between Akt from an unspecified species and human Tuberin.
    TSC2 Protein TSC1 GeneID BIND Hamartin interacts with tuberin
    TSC2 Protein YWHAQ GeneID BIND Tumor suppressor protein tuberin interacts with 14-3-3-tau isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-tau isoform.
    TSC2 Protein YWHAB GeneID BIND The tumor suppressor protein tuberin interacts with 14-3-3-beta isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-beta isoform.
    TSC2 Protein YWHAG GeneID BIND The tumor suppressor protein tuberin interacts with 14-3-3-gamma isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-gamma.
    TSC2 Protein YWHAE GeneID BIND Tumor suppressor protein tuberin interacts with 14-3-3-epsilon isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-epsilon isoform.
    TSC2 Protein YWHAH GeneID BIND The tumor suppressor protein tuberin interacts with 14-3-3-eta isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-eta isoform.
    TSC2 Protein YWHAZ GeneID BIND Tumor suppressor protein tuberin interacts with 14-3-3-zeta isoform.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TSC2 RNF123 270 0 0 323 1 1
    TSC2 NAA10 0 0 504 520 1 1
    TSC2 MLLT4 0 0 54 279 1 1
    TSC2 CDK11B 0 0 61 230 1 1
    TSC2 ARL17A 0 0 0 198 1 1
    TSC2 INPP1 0 0 141 165 1 1
    TSC2 ROCK1 0 0 450 479 1 1
    TSC2 SLBP 0 0 414 414 1 1
    TSC2 SMAD3 270 0 217 407 1 1
    TSC2 NOTCH3 0 0 137 166 1 1
    TSC2 ENSG00000267318 0 0 0 323 1 1
    TSC2 IL4 0 0 188 645 1 1
    TSC2 WNT9B 0 0 73 172 1 1
    TSC2 TPTE 0 0 0 237 1 1
    TSC2 ENSG00000272822 0 0 0 198 1 1
    TSC2 CSNK2A2 0 0 143 217 1 1
    TSC2 SH3PXD2B 0 0 0 283 1 1
    TSC2 RAP1B 0 0 112 258 1 1
    TSC2 SLC12A2 0 0 117 202 1 1
    TSC2 PDGFRB 0 0 315 330 1 1
    TSC2 NUMB 0 0 73 240 1 1
    TSC2 EP300 0 0 265 343 1 1
    TSC2 STK35 0 0 0 194 1 1
    TSC2 ADCY5 0 0 357 394 1 1
    TSC2 MARK3 0 0 108 167 1 1
    TSC2 ADIPOR1 0 0 180 194 1 1
    TSC2 CHD1 0 0 0 150 1 1
    TSC2 CDK5 0 0 166 184 1 2
    TSC2 CUL1 0 0 218 323 1 1
    TSC2 CASP7 0 0 210 273 1 1
    TSC2 EIF4E2 0 0 91 175 1 1
    TSC2 ELAVL1 0 0 183 185 1 1
    TSC2 RAP2A 0 0 161 299 1 1
    TSC2 PVALB 0 0 161 178 1 1
    TSC2 RABEP1 213 0 635 747 1 1
    TSC2 ENSG00000255863 0 0 0 198 1 1
    TSC2 KAT2A 0 0 54 333 1 1
    TSC2 SDHA 0 0 235 235 1 1
    TSC2 CCL2 0 0 181 181 1 2
    TSC2 ALB 0 0 360 426 1 1
    TSC2 DCLK1 0 0 0 190 1 1
    TSC2 SGK2 0 0 142 558 1 1
    TSC2 CASP8 0 0 278 282 1 2
    TSC2 EIF4A1 0 0 401 535 1 1
    TSC2 OTULIN 270 0 0 276 1 1
    TSC2 ALK 0 0 330 351 1 1
    TSC2 CUL5 0 0 141 183 1 1
    TSC2 DCTN1 0 0 0 159 1 1
    TSC2 WNT1 0 0 180 304 1 1
    TSC2 PAX6 0 0 150 151 1 1
    TSC2 RHOB 0 0 100 277 1 1
    TSC2 MAP1B 0 0 234 234 1 1
    TSC2 INVS 0 0 193 198 1 1
    TSC2 H2AFX 0 0 167 167 1 1
    TSC2 SMARCE1 0 0 91 214 1 1
    TSC2 LGALS4 0 0 285 316 1 1
    TSC2 BOLA2B 0 0 0 419 1 1
    TSC2 STK32A 0 0 0 323 1 1
    TSC2 PIK3R5 0 0 260 260 1 1
    TSC2 TSC22D1 0 0 54 156 1 1
    TSC2 FKBP5 0 0 82 154 1 1
    TSC2 H3F3B 0 0 184 183 1 1
    TSC2 TBC1D2 0 0 113 221 1 1
    TSC2 SLC3A2 0 0 260 289 1 1
    TSC2 CDH1 0 0 323 323 1 1
    TSC2 RAP2B 0 0 461 550 1 1
    TSC2 IDH1 0 0 294 294 1 1
    TSC2 SH3PXD2A 0 0 60 297 1 1
    TSC2 IGF2BP1 118 0 67 168 1 1
    TSC2 PRKCZ 0 0 181 207 1 1
    TSC2 MLXIPL 0 0 217 217 1 1
    TSC2 COL20A1 184 0 0 183 1 1
    TSC2 RERG 0 0 0 198 1 1
    TSC2 CDK16 0 0 46 211 1 1
    TSC2 PDGFRA 0 0 299 299 1 1
    TSC2 MIOS 0 0 325 480 1 1
    TSC2 SIRT6 0 0 275 290 1 1
    TSC2 HDAC8 105 0 74 159 1 1
    TSC2 KMT2B 0 0 155 191 1 1
    TSC2 CDK6 0 0 292 470 1 1
    TSC2 YWHAG 697 900 702 991 1 1
    TSC2 MAPKAPK2 213 900 167 931 1 1
    TSC2 ACTN2 0 0 444 444 1 1
    TSC2 VPS33A 0 0 96 213 1 1
    TSC2 PLD1 0 0 216 386 1 1
    TSC2 RBPMS 0 0 42 199 1 1
    TSC2 ENO2 0 0 141 159 1 1
    TSC2 BCKDK 0 0 113 184 1 1
    TSC2 FOXP1 0 0 164 184 1 1
    TSC2 RAPGEF1 0 0 76 172 1 1
    TSC2 BRAF 0 0 155 298 1 1
    TSC2 ATP6V0D2 0 0 0 210 1 1
    TSC2 ARL4D 0 0 0 198 1 1
    TSC2 PRKAB1 0 900 519 969 1 2
    TSC2 ARL9 0 0 0 198 1 1
    TSC2 CBFA2T3 0 0 73 216 1 1
    TSC2 SKP2 0 0 270 301 1 1
    TSC2 MAPK8 0 0 340 350 1 2
    TSC2 PEX5 0 0 491 503 1 1
    TSC2 PTK2 270 0 231 414 1 1
    TSC2 RUVBL1 0 0 145 178 1 1
    TSC2 ADIPOQ 0 0 313 313 1 1
    TSC2 SHANK2 0 0 391 437 1 1
    TSC2 SMARCB1 0 0 321 326 1 1
    TSC2 NR3C1 0 0 164 177 1 1
    TSC2 FKBP1A 0 0 602 695 1 2
    TSC2 RPS6KB2 0 0 517 823 1 2
    TSC2 BAZ1B 0 0 54 170 1 1
    TSC2 FXR1 0 0 93 192 1 1
    TSC2 RASA4 0 0 0 315 1 1
    TSC2 CTGF 0 0 165 165 1 1
    TSC2 HIST2H3PS2 0 0 265 265 1 1
    TSC2 PXN 0 0 210 227 1 1
    TSC2 SESN2 0 0 731 803 1 2
    TSC2 TNS1 0 0 500 602 1 1
    TSC2 CDK11A 209 0 54 303 1 1
    TSC2 ACAP3 0 0 0 154 1 1
    TSC2 FBXO7 0 0 81 163 1 2
    TSC2 GNAS 0 0 252 252 1 1
    TSC2 TRIM55 192 0 0 192 1 1
    TSC2 PPARA 0 0 263 274 1 1
    TSC2 BPTF 0 0 0 184 1 1
    TSC2 PDCD4 0 0 304 347 1 1
    TSC2 NES 0 0 261 307 1 1
    TSC2 RPTOR 0 900 882 994 1 2
    TSC2 ZNF77 0 0 135 174 1 1
    TSC2 HSPB3 0 0 181 181 1 1
    TSC2 MYCL 0 0 182 181 1 1
    TSC2 GPHN 0 0 140 166 1 1
    TSC2 RDX 0 0 216 238 1 1
    TSC2 DICER1 0 0 206 239 1 1
    TSC2 PIK3R1 0 0 463 481 1 1
    TSC2 UBE4B 0 0 54 210 1 1
    TSC2 HSPA4 0 0 246 247 1 1
    TSC2 PMEL 0 0 213 213 1 1
    TSC2 COL5A1 0 0 308 309 1 1
    TSC2 FASN 62 0 322 377 1 1
    TSC2 SLC6A8 0 0 156 155 1 1
    TSC2 ARL11 0 0 0 198 1 1
    TSC2 EIF4A3 0 0 52 181 1 1
    TSC2 GAK 0 0 0 353 1 1
    TSC2 PRKAB2 0 900 232 950 1 1
    TSC2 SH3GLB1 0 0 251 250 1 2
    TSC2 NRXN2 0 0 218 225 1 1
    TSC2 EGF 0 0 460 471 1 1
    TSC2 IGFBP1 0 0 185 210 1 1
    TSC2 RAC3 0 0 0 258 1 1
    TSC2 MAPK9 0 0 164 170 1 2
    TSC2 TTI2 0 0 124 200 1 1
    TSC2 CIAO1 270 0 0 270 1 1
    TSC2 DGKZ 0 0 134 178 1 1
    TSC2 PLK2 270 0 151 363 1 1
    TSC2 OGG1 0 0 266 295 1 1
    TSC2 CYCS 0 0 324 323 1 1
    TSC2 CHEK2 0 0 369 378 1 1
    TSC2 RPS6KA3 0 800 560 931 1 1
    TSC2 CAMKK1 0 0 49 300 1 1
    TSC2 SESN3 0 0 396 558 1 1
    TSC2 TRAF6 0 0 195 216 1 2
    TSC2 PRRT2 0 0 193 193 1 1
    TSC2 POMC 0 0 205 205 1 1
    TSC2 ZNF135 0 0 183 183 1 1
    TSC2 SLC1A2 0 0 162 245 1 1
    TSC2 NANOG 0 0 161 161 1 1
    TSC2 FLCN 0 0 681 768 1 1
    TSC2 ARL5C 0 0 0 198 1 1
    TSC2 ITPR1 0 0 210 210 1 2
    TSC2 RPS6KA4 0 0 122 329 1 1
    TSC2 ATG4A 0 0 162 293 1 2
    TSC2 CASP9 0 0 390 393 1 1
    TSC2 PIK3CG 0 0 455 605 1 1
    TSC2 JAK3 0 0 172 198 1 1
    TSC2 ULK2 0 0 458 601 1 2
    TSC2 ARL17B 0 0 0 198 1 1
    TSC2 MANBA 0 0 0 175 1 1
    TSC2 HSPA1A 0 0 344 349 1 1
    TSC2 SIK2 0 0 181 203 1 1
    TSC2 ERBB4 0 0 247 294 1 1
    TSC2 CAV1 270 0 161 361 1 1
    TSC2 EIF2AK1 0 0 143 291 1 1
    TSC2 RASA4B 0 0 0 315 1 1
    TSC2 MDFI 218 0 0 218 1 1
    TSC2 CCNA2 0 0 454 454 1 1
    TSC2 RTN4R 0 0 46 192 1 1
    TSC2 AKT1S1 0 0 804 815 1 1
    TSC2 SLC16A3 0 0 150 168 1 1
    TSC2 SNCA 0 0 201 201 1 2
    TSC2 CHEK1 0 0 321 321 1 1
    TSC2 DNTT 0 0 151 150 1 1
    TSC2 ARL4A 0 0 0 198 1 1
    TSC2 GOLGB1 0 0 355 355 1 1
    TSC2 DVL3 0 0 55 188 1 1
    TSC2 DAPK1 270 0 840 882 1 2
    TSC2 RHOT1 0 0 0 198 1 1
    TSC2 PLCG1 0 0 143 212 1 1
    TSC2 MGRN1 0 0 0 228 1 1
    TSC2 ITPR3 0 0 184 183 1 1
    TSC2 JUN 0 0 391 403 1 1
    TSC2 MAPK12 0 0 124 214 1 1
    TSC2 CYP19A1 0 0 210 216 1 1
    TSC2 BRD3 0 0 58 163 1 1
    TSC2 DPYSL2 0 0 150 168 1 1
    TSC2 ARFGEF2 0 0 181 207 1 1
    TSC2 POLDIP3 0 0 211 236 1 1
    TSC2 CDH17 0 0 167 167 1 1
    TSC2 TSC1 913 900 990 999 1 2
    TSC2 NEK8 0 0 142 195 1 1
    TSC2 BCL2L11 0 0 394 394 1 1
    TSC2 NTHL1 0 0 539 556 1 1
    TSC2 RABL2A 0 0 0 198 1 1
    TSC2 SHH 0 0 193 199 1 1
    TSC2 CSNK1A1 0 0 89 200 1 1
    TSC2 NPRL3 0 0 467 693 1 1
    TSC2 GOLPH3L 0 0 61 201 1 1
    TSC2 MED12 0 0 242 313 1 1
    TSC2 TBC1D4 0 0 458 457 1 1
    TSC2 FKBP3 0 0 0 198 1 1
    TSC2 GTPBP4 0 0 283 282 1 1
    TSC2 ARNT 0 0 322 348 1 2
    TSC2 NCOA4 0 0 82 246 1 1
    TSC2 BMI1 115 0 108 176 1 1
    TSC2 LAMP2 0 0 530 539 1 2
    TSC2 SSTR5 0 0 437 449 1 1
    TSC2 NEMF 0 0 60 185 1 1
    TSC2 YWHAE 655 900 370 980 1 1
    TSC2 LCK 0 0 150 183 1 1
    TSC2 FYN 0 0 150 184 1 1
    TSC2 GRIN2A 0 0 261 261 1 1
    TSC2 RSPH6A 0 0 127 150 1 1
    TSC2 GRB2 94 0 294 346 1 1
    TSC2 ARL10 0 0 0 198 1 1
    TSC2 ENSG00000270024 0 0 305 650 1 1
    TSC2 MMP2 0 0 203 203 1 1
    TSC2 SOX13 0 0 0 153 1 1
    TSC2 WBSCR16 0 0 113 151 1 1
    TSC2 EI24 0 0 142 160 1 2
    TSC2 TFAM 0 0 218 231 1 1
    TSC2 ETV1 0 0 142 162 1 1
    TSC2 MON1B 0 0 325 328 1 1
    TSC2 RBFOX1 0 0 247 248 1 1
    TSC2 RASD1 0 0 96 244 1 1
    TSC2 CD8A 0 0 261 261 1 1
    TSC2 IRS2 0 0 457 563 1 1
    TSC2 DEPDC5 0 0 610 724 1 1
    TSC2 MCOLN3 0 0 103 163 1 1
    TSC2 EIF2AK2 0 0 123 203 1 2
    TSC2 ARID1B 0 0 227 252 1 1
    TSC2 IGFBP3 0 0 315 333 1 1
    TSC2 RAP2C 0 0 0 198 1 1
    TSC2 TPM1 0 0 66 175 1 1
    TSC2 VEPH1 0 0 113 206 1 1
    TSC2 AURKA 0 0 184 183 1 2
    TSC2 SYN1 0 0 202 223 1 1
    TSC2 RCN2 0 0 243 246 1 1
    TSC2 SLC38A2 0 0 154 192 1 1
    TSC2 RHOQ 0 0 88 243 1 1
    TSC2 CXCL12 0 0 138 151 1 1
    TSC2 RNF43 0 0 143 152 1 1
    TSC2 ERAS 0 0 119 264 1 1
    TSC2 SPP1 0 0 124 184 1 1
    TSC2 CDKN1A 0 0 363 399 1 2
    TSC2 SCN1B 0 0 166 165 1 1
    TSC2 GATSL3 0 0 358 358 1 1
    TSC2 ENSG00000249884 0 0 0 164 1 1
    TSC2 ATG9A 0 0 218 511 1 2
    TSC2 HSPA8 0 0 175 207 1 2
    TSC2 INSR 0 0 205 351 1 1
    TSC2 USP33 0 0 72 275 1 2
    TSC2 CRTC2 0 0 267 282 1 1
    TSC2 EPCAM 0 0 170 169 1 1
    TSC2 EIF4G1 0 0 557 613 1 2
    TSC2 AR 0 0 298 308 1 1
    TSC2 PARP1 0 0 183 221 1 2
    TSC2 RHOA 0 0 360 488 1 1
    TSC2 MAP4K5 0 0 0 237 1 1
    TSC2 SIRT7 0 0 278 293 1 1
    TSC2 FOXA3 0 0 0 156 1 1
    TSC2 GIGYF2 0 0 59 204 1 1
    TSC2 ZEB1 0 0 141 159 1 1
    TSC2 EFHC1 0 0 156 155 1 1
    TSC2 RALB 0 0 167 304 1 1
    TSC2 GABARAPL1 0 0 423 475 1 2
    TSC2 NOP56 0 0 444 444 1 1
    TSC2 PDK2 0 0 325 357 1 1
    TSC2 DEFB126 0 0 54 150 1 1
    TSC2 VPS16 0 0 120 168 1 1
    TSC2 RHOG 0 0 74 226 1 1
    TSC2 RAB1A 116 0 134 202 1 2
    TSC2 ENSG00000271810 0 0 0 198 1 1
    TSC2 IGFBP2 0 0 204 208 1 1
    TSC2 USP6 0 0 984 985 1 1
    TSC2 PCDH19 0 0 323 323 1 1
    TSC2 RASL12 0 0 0 198 1 1
    TSC2 ESR2 0 0 430 439 1 1
    TSC2 SOX2 0 0 217 246 1 1
    TSC2 NRBP1 0 0 0 155 1 1
    TSC2 WRN 0 0 103 159 1 1
    TSC2 RHOV 0 0 0 198 1 1
    TSC2 CEBPA 0 0 184 183 1 1
    TSC2 PSEN1 0 0 147 178 1 2
    TSC2 TP73 0 0 99 152 1 2
    TSC2 ATF2 0 0 71 157 1 1
    TSC2 ASS1 0 0 500 499 1 1
    TSC2 COX4I1 0 0 230 229 1 1
    TSC2 TFEB 0 0 544 586 1 2
    TSC2 PAX8 0 0 181 181 1 1
    TSC2 PNPLA2 0 0 173 195 1 1
    TSC2 HSP90AA1 0 0 328 353 1 2
    TSC2 HDAC4 0 0 134 177 1 1
    TSC2 E2F7 0 0 143 150 1 1
    TSC2 FBXW7 0 0 295 312 1 1
    TSC2 MMP9 0 0 236 236 1 1
    TSC2 KEAP1 0 0 298 392 1 2
    TSC2 ROS1 0 0 213 238 1 1
    TSC2 MAPK3 213 900 603 971 1 2
    TSC2 RND1 0 0 59 213 1 1
    TSC2 KLF15 0 0 160 167 1 1
    TSC2 SIRT3 0 0 286 301 1 2
    TSC2 CUL4A 0 0 328 368 1 1
    TSC2 KMT2C 0 0 268 273 1 1
    TSC2 ARL6 0 0 0 198 1 1
    TSC2 GLI3 0 0 134 188 1 1
    TSC2 PCK2 0 0 170 176 1 1
    TSC2 NAA15 0 0 150 212 1 1
    TSC2 BNIP3 0 0 459 513 1 2
    TSC2 SQSTM1 0 0 504 532 1 2
    TSC2 CUL9 0 0 45 168 1 1
    TSC2 ATG13 0 0 602 699 1 2
    TSC2 INS 0 0 654 661 1 1
    TSC2 ACTB 0 0 505 527 1 1
    TSC2 FOXG1 0 0 117 602 1 1
    TSC2 RNGTT 209 0 0 355 1 1
    TSC2 RWDD2B 0 0 0 207 1 1
    TSC2 MSN 0 0 194 216 1 1
    TSC2 MED25 0 0 0 167 1 1
    TSC2 SLC7A3 0 0 103 264 1 1
    TSC2 KCNT1 0 0 251 250 1 1
    TSC2 DNMT1 0 0 151 151 1 1
    TSC2 STUB1 0 0 171 190 1 2
    TSC2 RPS6KA6 0 800 112 860 1 1
    TSC2 ENSG00000270249 0 0 0 315 1 1
    TSC2 PRKAG1 0 900 163 935 1 1
    TSC2 SPERT 218 0 0 218 1 1
    TSC2 CACNA1C 0 0 208 208 1 1
    TSC2 DCLK3 0 0 0 190 1 1
    TSC2 ARL1 0 0 0 198 1 1
    TSC2 RHOBTB1 0 0 0 198 1 1
    TSC2 PASK 0 0 0 165 1 1
    TSC2 RAB17 0 0 107 242 1 1
    TSC2 HBA1 0 0 294 294 1 1
    TSC2 ARL8A 0 0 0 198 1 1
    TSC2 APP 0 0 216 216 1 1
    TSC2 EGR1 0 0 153 152 1 1
    TSC2 AUTS2 0 0 113 186 1 1
    TSC2 CDC73 0 0 167 252 1 1
    TSC2 LIPE 0 0 150 169 1 1
    TSC2 SCN1A 0 0 391 390 1 1
    TSC2 CTNNB1 0 0 517 552 1 1
    TSC2 MSH6 0 0 294 297 1 1
    TSC2 MAP1LC3A 0 0 269 469 1 2
    TSC2 HRAS 0 0 608 730 1 1
    TSC2 CDK2 0 0 370 490 1 1
    TSC2 SLC1A7 0 0 374 387 1 1
    TSC2 ARF3 0 0 321 432 1 1
    TSC2 MAPK13 0 0 73 168 1 1
    TSC2 NDRG1 0 0 296 346 1 1
    TSC2 CXCL8 0 0 181 181 1 1
    TSC2 MAPKAPK5 0 0 235 246 1 1
    TSC2 RAB5A 463 0 416 684 1 2
    TSC2 IL1B 0 0 246 245 1 1
    TSC2 FAT1 0 0 155 154 1 1
    TSC2 BAG3 0 0 96 178 1 2
    TSC2 PRKCB 0 0 171 171 1 2
    TSC2 EN2 0 0 141 202 1 1
    TSC2 HIF1A 0 0 566 612 1 2
    TSC2 SIRT5 0 0 265 281 1 1
    TSC2 SH3BP4 0 0 218 218 1 1
    TSC2 NEDD4 0 0 143 244 1 2
    TSC2 GCK 0 0 150 173 1 1
    TSC2 RPS6 0 0 739 851 1 1
    TSC2 TNFRSF1A 0 0 155 154 1 1
    TSC2 E2F6 0 0 142 166 1 1
    TSC2 PLEK 0 0 520 530 1 1
    TSC2 STAT1 0 0 206 231 1 1
    TSC2 BRD2 0 0 62 159 1 1
    TSC2 H3F3A 0 0 183 195 1 1
    TSC2 HGFAC 0 0 193 193 1 1
    TSC2 GRM8 0 0 0 202 1 1
    TSC2 ELAVL3 0 0 181 181 1 1
    TSC2 RAD51C 0 0 166 186 1 1
    TSC2 FOXO6 0 0 217 236 1 1
    TSC2 DOCK7 0 0 181 232 1 1
    TSC2 CTRL 0 0 150 171 1 1
    TSC2 PIRT 0 0 142 160 1 1
    TSC2 IGFBP7 0 0 54 338 1 1
    TSC2 IL6 0 0 325 325 1 1
    TSC2 RAB12 0 0 0 198 1 2
    TSC2 UCP2 0 0 156 180 1 1
    TSC2 PALB2 0 0 282 282 1 1
    TSC2 PPP4C 0 0 0 163 1 1
    TSC2 CXXC1 0 0 64 162 1 1
    TSC2 PIK3C3 0 0 602 774 1 2
    TSC2 PRKG1 0 0 151 218 1 1
    TSC2 MED15 0 0 0 155 1 1
    TSC2 POTEF 0 0 141 180 1 1
    TSC2 SMO 0 0 0 183 1 1
    TSC2 CALM1 486 0 0 530 1 1
    TSC2 MAPKAP1 0 900 546 977 1 1
    TSC2 MTOR 0 900 982 999 1 2
    TSC2 SMARCAD1 0 0 0 164 1 1
    TSC2 RHOU 0 0 0 198 1 1
    TSC2 RAD51 0 0 135 157 1 1
    TSC2 TBR1 0 0 277 277 1 1
    TSC2 SCO2 0 0 321 321 1 1
    TSC2 NOTCH1 0 0 392 432 1 1
    TSC2 ARHGAP33 0 0 54 353 1 1
    TSC2 ARAF 0 0 293 428 1 1
    TSC2 MAN2C1 0 0 0 197 1 1
    TSC2 MARK4 0 0 181 198 1 1
    TSC2 FGF13 0 0 161 173 1 1
    TSC2 RRAS 0 0 75 227 1 1
    TSC2 PEX19 0 0 489 489 1 1
    TSC2 PRICKLE1 0 0 100 191 1 1
    TSC2 CXCR4 0 0 178 177 1 2
    TSC2 PLK1 270 0 519 651 1 1
    TSC2 NRBP2 0 0 0 164 1 1
    TSC2 IQGAP1 0 0 54 232 1 1
    TSC2 RELN 0 0 344 345 1 1
    TSC2 EPO 0 0 186 186 1 1
    TSC2 C12orf66 0 0 219 219 1 1
    TSC2 CUL7 0 0 134 298 1 1
    TSC2 SIRT2 0 0 287 302 1 2
    TSC2 PPP2R2A 0 0 103 209 1 1
    TSC2 U2AF1L4 0 0 144 162 1 1
    TSC2 ZKSCAN3 0 0 172 171 1 2
    TSC2 TRIP12 0 0 81 193 1 1
    TSC2 RHOJ 0 0 0 198 1 1
    TSC2 FBXO32 0 0 323 353 1 2
    TSC2 LAMTOR5 0 900 270 923 1 1
    TSC2 MGMT 0 0 230 229 1 1
    TSC2 SLC38A9 0 900 458 947 1 1
    TSC2 RAPGEF4 0 0 156 161 1 1
    TSC2 ANXA5 0 0 324 366 1 1
    TSC2 FAM129A 0 0 209 258 1 1
    TSC2 CCNB1 0 0 723 730 1 1
    TSC2 INPPL1 0 0 204 317 1 1
    TSC2 GRIA2 0 0 140 165 1 1
    TSC2 FGF21 0 0 143 196 1 1
    TSC2 RRN3 0 0 193 219 1 1
    TSC2 ARL14 0 0 0 198 1 1
    TSC2 NLGN3 0 0 505 527 1 1
    TSC2 POLE 0 0 217 240 1 1
    TSC2 CREB1 0 0 367 381 1 1
    TSC2 STAG2 0 0 140 180 1 1
    TSC2 APC 0 0 143 180 1 1
    TSC2 IFNG 0 0 112 173 1 2
    TSC2 RAPGEF3 0 0 138 172 1 1
    TSC2 WWP1 0 0 48 153 1 1
    TSC2 BAP1 0 0 126 169 1 1
    TSC2 IGFBP5 0 0 90 338 1 1
    TSC2 ARF1 114 0 180 367 1 1
    TSC2 RHOBTB2 0 0 45 202 1 1
    TSC2 ARL3 0 0 0 198 1 1
    TSC2 CREBBP 0 0 260 379 1 1
    TSC2 CLIP1 0 0 140 177 1 1
    TSC2 TENC1 0 0 0 237 1 1
    TSC2 PFKFB3 0 0 367 405 1 1
    TSC2 GRB10 0 0 404 414 1 1
    TSC2 SDHB 0 0 330 330 1 1
    TSC2 ESRRA 0 0 181 193 1 1
    TSC2 RUNX1T1 0 0 0 189 1 1
    TSC2 ABL1 0 0 231 271 1 1
    TSC2 NF1 0 0 660 719 1 1
    TSC2 ELF1 0 0 0 176 1 1
    TSC2 MAP2K7 0 0 559 559 1 1
    TSC2 TNFAIP8L1 0 0 138 159 1 1
    TSC2 SMG1 0 0 215 527 1 1
    TSC2 BRSK2 0 0 457 457 1 1
    TSC2 RCE1 0 0 91 193 1 1
    TSC2 RPS6KA5 0 0 95 349 1 1
    TSC2 PRR5 0 900 564 955 1 1
    TSC2 ATRX 0 0 455 491 1 1
    TSC2 SNW1 0 900 46 903 1 1
    TSC2 FKBP8 0 0 460 519 1 1
    TSC2 ARL5B 0 0 0 198 1 1
    TSC2 GABARAPL2 0 0 414 454 1 2
    TSC2 RAP1A 487 0 166 627 1 1
    TSC2 ATG14 0 0 468 532 1 2
    TSC2 ZFYVE16 0 0 61 175 1 1
    TSC2 RIT2 0 0 0 198 1 1
    TSC2 LARS2 0 0 289 395 1 1
    TSC2 GAPDH 0 0 460 475 1 2
    TSC2 CHD7 0 0 152 220 1 1
    TSC2 TLR4 0 0 184 183 1 1
    TSC2 KSR2 0 0 143 225 1 1
    TSC2 SMAD2 270 0 416 556 1 1
    TSC2 NMNAT1 0 0 82 151 1 1
    TSC2 FGFR2 0 0 247 246 1 1
    TSC2 TRAF3IP1 0 0 328 328 1 1
    TSC2 RELA 0 0 195 242 1 1
    TSC2 RAB40AL 0 0 260 260 1 1
    TSC2 BCL2L1 0 0 456 456 1 2
    TSC2 BBS4 0 0 135 174 1 1
    TSC2 SPRYD4 0 0 90 188 1 1
    TSC2 STRADA 0 0 464 482 1 1
    TSC2 DNMT3A 0 0 157 186 1 1
    TSC2 XPA 0 0 81 220 1 1
    TSC2 TPO 0 0 380 380 1 1
    TSC2 PHLPP1 0 0 391 484 1 1
    TSC2 PIK3R4 0 0 425 510 1 2
    TSC2 CABIN1 0 0 0 165 1 1
    TSC2 USP10 0 0 101 167 1 2
    TSC2 ACACA 0 0 246 256 1 1
    TSC2 GAB2 0 0 154 153 1 1
    TSC2 TMEM127 0 0 235 235 1 1
    TSC2 WWTR1 0 0 113 164 1 1
    TSC2 PIK3CA 0 0 654 750 1 2
    TSC2 SCN2A 0 0 288 288 1 1
    TSC2 GNAQ 0 0 245 244 1 1
    TSC2 DVL1 0 0 146 267 1 1
    TSC2 RUVBL2 270 0 57 295 1 1
    TSC2 MYH10 0 0 82 175 1 1
    TSC2 PIK3R3 0 0 294 318 1 1
    TSC2 EFTUD2 0 0 0 188 1 1
    TSC2 G6PC 0 0 203 203 1 1
    TSC2 FKBP1B 0 0 48 271 1 1
    TSC2 APPL1 0 0 325 345 1 1
    TSC2 PIM1 0 0 307 368 1 1
    TSC2 RICTOR 105 900 940 997 1 2
    TSC2 SLC7A1 0 0 100 273 1 1
    TSC2 OFD1 0 0 152 151 1 1
    TSC2 GLS 0 0 212 216 1 1
    TSC2 TRAF2 0 0 113 173 1 1
    TSC2 MEN1 0 0 503 517 1 1
    TSC2 P4HB 0 0 136 195 1 2
    TSC2 YTHDF2 0 0 0 166 1 1
    TSC2 SDHAF2 0 0 208 208 1 1
    TSC2 PPARGC1A 0 0 454 524 1 1
    TSC2 RIT1 0 0 0 198 1 1
    TSC2 ADNP 0 0 117 168 1 1
    TSC2 RASAL1 0 0 74 338 1 1
    TSC2 PI3 0 0 280 280 1 1
    TSC2 NLGN2 0 0 240 261 1 1
    TSC2 IGF1R 105 0 517 632 1 1
    TSC2 SDHC 0 0 266 266 1 1
    TSC2 DIRC2 0 0 162 161 1 1
    TSC2 IFT20 0 0 123 160 1 1
    TSC2 VPS13B 0 0 134 241 1 1
    TSC2 WDR44 0 0 92 154 1 1
    TSC2 PARK2 0 0 260 269 1 1
    TSC2 NR0B2 0 0 63 174 1 1
    TSC2 SLC6A4 0 0 134 188 1 1
    TSC2 ILK 0 0 234 287 1 1
    TSC2 WNT5A 0 0 104 168 1 1
    TSC2 FCGR1B 0 0 161 161 1 1
    TSC2 IDH3G 0 0 0 159 1 1
    TSC2 STK32B 0 0 0 323 1 1
    TSC2 TBC1D24 0 0 150 153 1 1
    TSC2 ARL8B 0 0 113 259 1 1
    TSC2 MYC 0 0 571 580 1 2
    TSC2 PPRC1 0 0 74 404 1 1
    TSC2 IL15 0 0 134 152 1 1
    TSC2 PDK1 0 0 310 343 1 1
    TSC2 SLC1A3 0 0 145 230 1 1
    TSC2 ODC1 0 0 202 202 1 1
    TSC2 BOLA2 0 0 0 419 1 1
    TSC2 ST13 0 0 150 203 1 2
    TSC2 MAP2K1 0 0 467 533 1 1
    TSC2 CAND1 115 0 99 190 1 1
    TSC2 BRCA1 0 0 393 392 1 1
    TSC2 PFKM 0 0 263 263 1 1
    TSC2 STK11 0 0 760 867 1 2
    TSC2 PHLDA3 0 0 160 159 1 1
    TSC2 RSG1 0 0 0 198 1 1
    TSC2 AKT2 213 900 566 980 1 1
    TSC2 LMBR1L 270 0 74 295 1 1
    TSC2 EIF2B5 0 0 150 150 1 1
    TSC2 MZT2B 0 0 0 156 1 1
    TSC2 NFE2L2 0 0 286 286 1 1
    TSC2 AP1AR 0 0 514 514 1 1
    TSC2 EHMT2 0 0 92 180 1 1
    TSC2 WDR62 0 0 103 157 1 1
    TSC2 ZC3H7A 0 0 0 181 1 1
    TSC2 MECP2 0 0 469 469 1 1
    TSC2 CAB39 0 0 392 405 1 1
    TSC2 FBXW8 0 0 160 178 1 1
    TSC2 RB1CC1 0 0 746 792 1 2
    TSC2 LARP1 0 0 189 245 1 1
    TSC2 GOLPH3 0 0 112 175 1 1
    TSC2 NGDN 0 0 562 577 1 1
    TSC2 VPS39 0 0 240 331 1 1
    TSC2 SHANK1 0 0 325 396 1 1
    TSC2 EFNA5 0 0 482 482 1 1
    TSC2 CYFIP1 0 0 322 340 1 1
    TSC2 TFEC 0 0 142 221 1 1
    TSC2 EIF5B 0 0 254 288 1 1
    TSC2 CCNT1 209 0 0 357 1 1
    TSC2 LRP1B 0 0 144 165 1 1
    TSC2 HDAC5 0 0 95 184 1 1
    TSC2 MTA1 0 0 70 159 1 1
    TSC2 UBA1 0 0 90 201 1 1
    TSC2 FLNA 0 0 216 216 1 1
    TSC2 SMAD4 0 0 310 317 1 1
    TSC2 LRP5 0 0 147 186 1 1
    TSC2 MYCN 0 0 255 314 1 1
    TSC2 MKNK2 0 0 125 211 1 1
    TSC2 ITFG2 0 0 170 169 1 1
    TSC2 SLC2A3 0 0 213 227 1 1
    TSC2 ANKRD16 0 0 0 256 1 1
    TSC2 MAP1A 0 0 218 218 1 1
    TSC2 ARF5 0 0 0 198 1 1
    TSC2 RAB10 0 0 292 292 1 1
    TSC2 MAP3K7 0 0 162 188 1 1
    TSC2 HDAC2 0 0 148 171 1 1
    TSC2 EMX1 0 0 260 261 1 1
    TSC2 DDIT3 0 0 282 282 1 2
    TSC2 SLC7A5 0 0 334 366 1 1
    TSC2 TNS3 0 0 0 237 1 1
    TSC2 PAM 270 0 0 270 1 1
    TSC2 RBL1 0 0 123 233 1 1
    TSC2 CUL2 0 0 160 181 1 1
    TSC2 PFKFB2 0 0 194 242 1 1
    TSC2 HK2 0 0 370 370 1 1
    TSC2 NRXN3 0 0 218 225 1 1
    TSC2 LMNA 0 0 167 167 1 1
    TSC2 SLC2A2 0 0 134 150 1 1
    TSC2 RAF1 0 0 391 532 1 2
    TSC2 BRSK1 0 0 136 154 1 1
    TSC2 CFLAR 0 0 181 186 1 1
    TSC2 EGFR 0 0 556 589 1 1
    TSC2 CDK4 270 0 560 749 1 1
    TSC2 MYD88 0 0 140 206 1 1
    TSC2 HTT 0 0 295 359 1 1
    TSC2 TSC22D4 0 0 0 153 1 1
    TSC2 RAB4A 0 0 103 250 1 1
    TSC2 FGFR3 0 0 324 323 1 1
    TSC2 FADD 0 0 160 166 1 2
    TSC2 LAMP1 0 0 310 389 1 2
    TSC2 SLC2A1 0 0 459 469 1 1
    TSC2 RAB2A 0 0 0 198 1 1
    TSC2 MARK1 0 0 166 184 1 1
    TSC2 ATP6V0C 0 0 413 412 1 2
    TSC2 CFTR 0 0 184 183 1 1
    TSC2 ENSG00000273637 0 0 0 416 1 1
    TSC2 RASGRP1 0 0 163 163 1 1
    TSC2 TP53 0 0 669 706 1 2
    TSC2 MDM2 0 0 508 517 1 1
    TSC2 SLC12A5 0 0 138 230 1 1
    TSC2 GART 0 0 0 278 1 1
    TSC2 ERCC2 0 0 158 178 1 1
    TSC2 PKHD1 0 0 277 277 1 1
    TSC2 PPP1R12C 0 0 210 232 1 1
    TSC2 STAT3 0 0 457 457 1 2
    TSC2 GDNF 0 0 140 158 1 1
    TSC2 MPDZ 0 0 0 172 1 1
    TSC2 EZH2 0 0 244 262 1 1
    TSC2 HTRA1 192 0 453 539 1 1
    TSC2 CD300C 0 0 218 218 1 1
    TSC2 EIF2AK4 0 0 324 514 1 1
    TSC2 CDK14 0 0 74 356 1 1
    TSC2 UBR5 0 0 49 202 1 1
    TSC2 NF2 0 0 503 526 1 1
    TSC2 GATA3 0 0 157 169 1 1
    TSC2 LAMTOR4 0 900 367 933 1 1
    TSC2 MCOLN1 0 0 135 153 1 1
    TSC2 MYH6 0 0 112 177 1 1
    TSC2 NASP 0 0 446 461 1 1
    TSC2 TRIM23 0 0 413 509 1 1
    TSC2 ERN1 0 0 302 339 1 2
    TSC2 NLGN4X 0 0 468 492 1 1
    TSC2 NPRL2 0 0 501 711 1 1
    TSC2 DAW1 0 0 57 195 1 1
    TSC2 ADCY1 0 0 327 366 1 1
    TSC2 BRD4 0 0 95 192 1 1
    TSC2 HUWE1 0 0 134 193 1 1
    TSC2 CAMKK2 0 0 470 614 1 2
    TSC2 MELK 0 0 81 162 1 1
    TSC2 MYBL1 0 0 134 152 1 1
    TSC2 BMP2K 0 0 0 169 1 1
    TSC2 NLGN1 0 0 262 278 1 1
    TSC2 POGZ 0 0 88 204 1 1
    TSC2 HDAC6 0 0 170 201 1 2
    TSC2 APAF1 0 0 181 182 1 1
    TSC2 MKNK1 0 0 260 269 1 1
    TSC2 CDH2 0 0 181 181 1 1
    TSC2 FNTA 0 0 386 447 1 1
    TSC2 JAK2 0 0 269 292 1 1
    TSC2 DIRAS1 0 0 0 198 1 1
    TSC2 SLC7A4 0 0 0 213 1 1
    TSC2 KIAA1549 0 0 252 252 1 1
    TSC2 GHRL 0 0 181 181 1 1
    TSC2 SYK 0 0 149 176 1 1
    TSC2 LEP 0 0 292 292 1 1
    TSC2 RHOT2 0 0 0 280 1 1
    TSC2 NFKBIA 0 0 234 238 1 1
    TSC2 KIT 0 0 391 390 1 1
    TSC2 PRKG2 0 0 0 200 1 1
    TSC2 C12orf5 271 0 381 529 1 1
    TSC2 KATNAL2 0 0 134 213 1 1
    TSC2 WT1 0 0 254 254 1 1
    TSC2 AMBRA1 0 0 423 435 1 2
    TSC2 LDHA 0 0 286 291 1 1
    TSC2 SREBF1 62 0 457 536 1 2
    TSC2 SLC36A4 0 0 96 217 1 1
    TSC2 MARK2 0 0 282 401 1 1
    TSC2 E2F3 0 0 167 191 1 1
    TSC2 NGFR 0 0 95 223 1 1
    TSC2 MAPK14 0 900 241 928 1 1
    TSC2 FBXL5 0 0 62 250 1 1
    TSC2 EIF4EBP3 0 0 260 391 1 1
    TSC2 HECW2 270 0 0 311 1 1
    TSC2 RPL10A 0 0 48 150 1 1
    TSC2 PTEN 0 0 770 909 1 2
    TSC2 BMPR1A 0 0 177 203 1 1
    TSC2 GABARAP 0 0 288 352 1 2
    TSC2 SLC2A14 0 0 232 246 1 1
    TSC2 MAPK7 0 0 124 185 1 1
    TSC2 KDM5C 0 0 323 347 1 1
    TSC2 PKD1P1 0 0 180 179 1 1
    TSC2 VEGFA 0 0 469 469 1 1
    TSC2 ARID2 0 0 284 284 1 1
    TSC2 KIAA0226 0 0 173 192 1 1
    TSC2 TELO2 0 0 95 219 1 1
    TSC2 E2F5 0 0 124 178 1 1
    TSC2 PRKAA2 0 900 272 954 1 2
    TSC2 NTRK3 0 0 194 219 1 1
    TSC2 PI4KB 0 0 59 349 1 1
    TSC2 RRAGB 270 900 699 991 1 2
    TSC2 MYOD1 0 0 150 168 1 1
    TSC2 WIPI1 0 0 323 342 1 2
    TSC2 DNM1L 0 0 134 188 1 2
    TSC2 RECQL4 0 0 142 158 1 1
    TSC2 ACTG1 0 0 157 173 1 1
    TSC2 PREX1 0 0 166 184 1 1
    TSC2 DLG4 0 0 293 340 1 1
    TSC2 IPCEF1 0 0 54 172 1 1
    TSC2 FOSB 0 0 0 213 1 1
    TSC2 ATG7 0 0 557 666 1 2
    TSC2 TGFBR2 0 0 184 210 1 1
    TSC2 TJP1 0 0 123 154 1 1
    TSC2 DAPK2 0 0 134 160 1 2
    TSC2 RBPJ 0 0 81 185 1 1
    TSC2 NAMPT 0 0 195 212 1 1
    TSC2 FLT3 0 0 260 260 1 1
    TSC2 CDK7 0 0 160 159 1 1
    TSC2 SNAI1 0 0 233 232 1 1
    TSC2 IL10 0 0 207 207 1 1
    TSC2 OPHN1 0 0 175 175 1 1
    TSC2 PTCHD1 0 0 138 157 1 1
    TSC2 FGFR4 0 0 181 181 1 1
    TSC2 MRAS 0 0 54 209 1 1
    TSC2 GFAP 0 0 270 282 1 2
    TSC2 NCK1 0 0 72 214 1 1
    TSC2 FERMT2 0 0 0 188 1 1
    TSC2 MRE11A 0 0 183 187 1 1
    TSC2 DAP 0 0 213 222 1 2
    TSC2 PRKAG3 0 900 144 933 1 1
    TSC2 EZR 0 0 231 252 1 1
    TSC2 ATM 0 0 673 722 1 1
    TSC2 SHC1 0 0 324 355 1 1
    TSC2 TRIM63 192 0 247 365 1 1
    TSC2 IDH2 0 0 260 260 1 1
    TSC2 EIF3F 0 0 194 221 1 1
    TSC2 AXIN1 270 0 700 781 1 1
    TSC2 CECR2 0 0 0 221 1 1
    TSC2 CTSD 0 0 156 155 1 2
    TSC2 RAP1GAP 0 0 459 227 1 1
    TSC2 CYGB 0 0 434 434 1 1
    TSC2 CDH10 0 0 161 173 1 1
    TSC2 IGF2 0 0 287 286 1 1
    TSC2 ENSG00000267261 0 0 0 237 1 1
    TSC2 DIRAS2 0 0 0 198 1 1
    TSC2 TTI1 0 0 391 460 1 1
    TSC2 MDM4 0 0 233 232 1 1
    TSC2 G6PD 0 0 212 229 1 1
    TSC2 NRXN1 0 0 421 426 1 1
    TSC2 UBE2O 0 0 101 153 1 1
    TSC2 RET 0 0 342 342 1 1
    TSC2 LATS1 0 0 140 163 1 1
    TSC2 STXBP4 0 0 0 185 1 1
    TSC2 SETD2 0 0 374 388 1 1
    TSC2 RASL10A 0 0 44 201 1 1
    TSC2 ULK1 0 0 633 737 1 2
    TSC2 NEK2 0 0 75 156 1 1
    TSC2 PRKCA 0 0 464 463 1 1
    TSC2 RPS6KA1 486 900 734 988 1 1
    TSC2 AKT3 213 900 647 983 1 1
    TSC2 SLC7A14 0 0 0 213 1 1
    TSC2 RASL11B 0 0 0 198 1 1
    TSC2 GEM 0 0 0 198 1 1
    TSC2 EML3 0 0 57 154 1 1
    TSC2 IKBKG 0 0 208 233 1 1
    TSC2 QARS 0 0 61 192 1 1
    TSC2 FN1 0 0 261 261 1 1
    TSC2 NUMA1 0 0 64 233 1 1
    TSC2 CASR 0 0 88 150 1 1
    TSC2 FNIP1 0 0 464 463 1 1
    TSC2 RALA 270 0 202 492 1 1
    TSC2 PSMD14 0 0 54 210 1 1
    TSC2 AGL 0 0 0 183 1 1
    TSC2 HSPB2 0 0 171 171 1 1
    TSC2 TERT 0 0 327 399 1 1
    TSC2 HIGD2A 0 0 57 152 1 1
    TSC2 TET2 0 0 164 163 1 1
    TSC2 DYRK1A 486 0 213 593 1 1
    TSC2 ARL13B 0 0 91 240 1 1
    TSC2 GLI1 0 0 202 202 1 1
    TSC2 HSPB1 0 0 171 172 1 1
    TSC2 NKX2-1 0 0 150 170 1 1
    TSC2 ESPN 0 0 0 171 1 1
    TSC2 ATG10 0 0 391 418 1 2
    TSC2 ARID1A 0 0 390 411 1 1
    TSC2 PTPRH 0 0 61 185 1 1
    TSC2 EFNA2 0 0 63 156 1 1
    TSC2 SMG6 0 0 0 181 1 1
    TSC2 MAP1LC3B 0 0 501 535 1 2
    TSC2 KPTN 0 0 250 266 1 1
    TSC2 PRKD1 0 0 354 354 1 1
    TSC2 SYP 0 0 217 217 1 1
    TSC2 YIPF1 0 0 181 181 1 1
    TSC2 PPT1 0 0 101 162 1 1
    TSC2 WNT3A 0 0 124 187 1 1
    TSC2 DYNC1H1 0 0 82 166 1 1
    TSC2 MT-ND1 0 0 0 188 1 1
    TSC2 CALCOCO2 0 0 194 194 1 2
    TSC2 TEX37 0 0 289 330 1 1
    TSC2 CNTNAP2 0 0 413 428 1 1
    TSC2 ATG5 0 0 557 684 1 2
    TSC2 KSR1 0 0 170 250 1 1
    TSC2 WDR90 0 0 66 163 1 1
    TSC2 PRKAG2 0 900 294 945 1 1
    TSC2 ATP4A 0 0 180 186 1 1
    TSC2 RAD51D 0 0 163 184 1 1
    TSC2 PUM1 0 0 0 169 1 1
    TSC2 PTPN1 0 0 137 155 1 1
    TSC2 XBP1 0 0 286 312 1 2
    TSC2 SOX6 0 0 0 153 1 1
    TSC2 YAP1 0 0 180 236 1 1
    TSC2 TP63 0 0 102 200 1 2
    TSC2 EOMES 0 0 357 357 1 1
    TSC2 MCL1 0 0 402 402 1 2
    TSC2 CDH9 0 0 181 181 1 1
    TSC2 RBM10 0 0 167 211 1 1
    TSC2 ELF4 0 0 112 248 1 1
    TSC2 SMARCA4 0 0 277 310 1 1
    TSC2 SIRT1 270 0 824 890 1 2
    TSC2 NUAK1 0 0 170 169 1 1
    TSC2 DDIT4L 0 0 421 436 1 1
    TSC2 KIF3A 0 0 181 201 1 1
    TSC2 CTSB 0 0 155 154 1 2
    TSC2 MSH2 0 0 294 296 1 1
    TSC2 ESR1 486 0 833 913 1 1
    TSC2 PIM2 0 0 434 484 1 2
    TSC2 RAC1 0 0 151 319 1 1
    TSC2 PPP1CA 297 0 71 394 1 1
    TSC2 LYN 0 0 142 169 1 1
    TSC2 CTSK 0 0 154 153 1 1
    TSC2 NSD1 0 0 212 255 1 1
    TSC2 EHMT1 0 0 108 170 1 1
    TSC2 PDIK1L 0 0 0 194 1 1
    TSC2 GNA11 0 0 202 202 1 1
    TSC2 POLD1 0 0 139 173 1 1
    TSC2 HOMER1 0 0 134 169 1 1
    TSC2 MAP3K5 0 0 261 261 1 1
    TSC2 OPTN 0 0 151 150 1 2
    TSC2 LZTR1 0 0 164 180 1 1
    TSC2 LRRK2 0 0 130 243 1 2
    TSC2 MLH1 0 0 267 298 1 1
    TSC2 GRIN2B 0 0 211 211 1 1
    TSC2 ELAVL4 0 0 161 161 1 1
    TSC2 CAD 0 0 155 174 1 1
    TSC2 CDKN2C 0 0 188 193 1 1
    TSC2 MET 0 0 298 320 1 1
    TSC2 CCDC88A 0 0 150 173 1 1
    TSC2 FLT4 0 0 194 199 1 1
    TSC2 MAPK11 0 900 204 927 1 1
    TSC2 PIM3 0 0 234 301 1 1
    TSC2 PMAIP1 0 0 274 274 1 1
    TSC2 CDKN2B 0 0 249 253 1 1
    TSC2 PIK3CB 0 0 465 614 1 1
    TSC2 IL2 0 0 211 211 1 1
    TSC2 PRKCSH 272 0 144 401 1 1
    TSC2 STXBP1 0 0 246 257 1 1
    TSC2 GYS1 0 0 149 211 1 1
    TSC2 EEF2K 0 0 460 472 1 2
    TSC2 WEE1 0 0 166 165 1 1
    TSC2 SUFU 0 0 217 253 1 1
    TSC2 ARF6 0 0 59 213 1 1
    TSC2 ARL4C 0 0 0 198 1 1
    TSC2 RASL11A 0 0 0 198 1 1
    TSC2 EIF4EBP2 0 0 492 793 1 1
    TSC2 BECN1 0 0 606 692 1 2
    TSC2 MAPT 0 0 201 201 1 2
    TSC2 DSCR3 0 0 45 177 1 1
    TSC2 SDC1 0 0 66 228 1 1
    TSC2 CARD11 0 0 180 193 1 1
    TSC2 ENSG00000267618 0 0 164 185 1 1
    TSC2 LPIN1 0 0 341 345 1 2
    TSC2 ARHGAP35 0 0 74 221 1 1
    TSC2 PDIA3 0 0 90 152 1 1
    TSC2 SEMA5A 0 0 108 187 1 1
    TSC2 RHOBTB3 0 0 0 198 1 1
    TSC2 SCN8A 0 0 164 163 1 1
    TSC2 CDK5R1 0 0 0 150 1 1
    TSC2 CDT1 0 0 145 232 1 1
    TSC2 REM2 0 0 0 198 1 1
    TSC2 USP20 0 0 61 278 1 1
    TSC2 CCDC18 0 0 112 190 1 1
    TSC2 CDC25A 0 0 150 168 1 1
    TSC2 RASL10B 0 0 0 198 1 1
    TSC2 MED1 0 900 0 903 1 1
    TSC2 RRAGD 270 900 519 976 1 1
    TSC2 TUBG2 0 0 0 157 1 1
    TSC2 SYNRG 0 0 53 241 1 1
    TSC2 RRAGC 270 900 769 988 1 1
    TSC2 CRKL 0 0 91 153 1 1
    TSC2 DEPTOR 0 900 682 969 1 1
    TSC2 MSTN 0 0 173 182 1 1
    TSC2 RAB11B 0 0 0 198 1 1
    TSC2 PTPN11 73 0 260 284 1 1
    TSC2 STAT5A 0 0 213 213 1 1
    TSC2 TCEB1 0 0 218 218 1 1
    TSC2 SOCS3 0 0 181 181 1 1
    TSC2 U2AFBP 0 0 144 162 1 1
    TSC2 MON1A 0 0 325 325 1 1
    TSC2 WDR59 0 0 294 486 1 1
    TSC2 PRKAR1A 0 0 181 241 1 2
    TSC2 RHOD 0 0 95 243 1 1
    TSC2 FOS 0 0 218 231 1 1
    TSC2 FASLG 0 0 170 169 1 1
    TSC2 TBC1D2B 0 0 0 158 1 1
    TSC2 YWHAZ 873 900 904 998 1 1
    TSC2 SOD2 0 0 202 235 1 1
    TSC2 RND2 0 0 66 219 1 1
    TSC2 NPHP1 0 0 166 165 1 1
    TSC2 THEM4 0 0 306 306 1 1
    TSC2 RP2 189 0 0 189 1 1
    TSC2 ASPSCR1 0 0 170 201 1 1
    TSC2 EPAS1 0 0 142 238 1 2
    TSC2 RAB39B 0 0 105 265 1 2
    TSC2 KRAS 0 0 460 663 1 1
    TSC2 TPTE2 0 0 0 237 1 1
    TSC2 FOXO1 270 0 812 868 1 2
    TSC2 BTRC 0 0 210 210 1 1
    TSC2 MLST8 0 900 792 988 1 2
    TSC2 EIF4A2 0 0 401 522 1 1
    TSC2 PNKD 208 0 0 208 1 1
    TSC2 NRAS 0 0 308 477 1 1
    TSC2 FOXK1 0 0 95 184 1 1
    TSC2 HSPA5 0 0 294 323 1 2
    TSC2 FOXP2 0 0 198 217 1 1
    TSC2 TFE3 0 0 509 593 1 1
    TSC2 E2F1 0 0 203 214 1 1
    TSC2 CHUK 0 0 320 421 1 1
    TSC2 CUL3 0 0 212 235 1 1
    TSC2 RIN1 0 0 94 159 1 1
    TSC2 WNT2 0 0 56 219 1 1
    TSC2 INSRR 0 0 0 209 1 1
    TSC2 RBL2 0 0 96 210 1 1
    TSC2 PBRM1 0 0 408 491 1 1
    TSC2 SIK1 0 0 147 170 1 1
    TSC2 GSK3B 487 900 576 982 1 2
    TSC2 FAT4 0 0 113 177 1 1
    TSC2 KRT7 0 0 166 179 1 1
    TSC2 TBC1D1 0 0 284 294 1 1
    TSC2 TUBG1 0 0 74 292 1 1
    TSC2 SFN 462 900 480 973 1 1
    TSC2 SST 0 0 233 232 1 1
    TSC2 KCNQ2 0 0 235 235 1 1
    TSC2 PPP6C 0 0 167 266 1 1
    TSC2 CDKN2A 0 0 466 469 1 2
    TSC2 RAB42 0 0 0 198 1 1
    TSC2 HDAC1 0 0 167 208 1 2
    TSC2 SCRIB 0 0 112 158 1 1
    TSC2 RAB26 0 0 182 181 1 1
    TSC2 WDR92 270 0 0 270 1 1
    TSC2 ERCC5 0 0 115 181 1 1
    TSC2 YWHAH 470 900 48 953 1 1
    TSC2 LAMTOR1 0 900 393 937 1 1
    TSC2 INPP4B 0 0 322 321 1 1
    TSC2 PIK3CD 0 0 421 583 1 1
    TSC2 TBC1D7 752 800 989 999 1 2
    TSC2 CEBPB 0 0 188 188 1 1
    TSC2 RASA2 0 0 69 507 1 1
    TSC2 ATG16L1 0 0 391 413 1 2
    TSC2 PI4KA 0 0 0 321 1 1
    TSC2 CHD8 0 0 310 355 1 1
    TSC2 STK24 0 0 181 196 1 1
    TSC2 SIPA1L1 0 0 244 205 1 1
    TSC2 AK1 0 0 290 290 1 1
    TSC2 RAB2B 0 0 0 198 1 1
    TSC2 CASP3 0 0 464 499 1 2
    TSC2 ERBB3 0 0 321 363 1 1
    TSC2 RAB4B 0 0 0 198 1 1
    TSC2 GAPVD1 0 0 358 364 1 1
    TSC2 FGF19 0 0 146 199 1 1
    TSC2 PTGS2 0 0 218 218 1 1
    TSC2 CDH16 0 0 124 152 1 1
    TSC2 EEF1A1 0 0 145 183 1 1
    TSC2 SMURF1 0 0 107 203 1 1
    TSC2 EPHA5 0 0 111 222 1 1
    TSC2 FIGF 0 0 325 325 1 1
    TSC2 FBXO45 0 0 150 334 1 1
    TSC2 LIMK1 0 0 103 174 1 1
    TSC2 DAXX 0 0 402 402 1 1
    TSC2 EIF4B 0 0 560 629 1 1
    TSC2 LIPC 0 0 82 319 1 1
    TSC2 AFP 0 0 166 218 1 1
    TSC2 CDC27 0 0 68 199 1 1
    TSC2 GABRB3 0 0 294 316 1 1
    TSC2 BRCA2 0 0 384 384 1 1
    TSC2 LNX1 192 0 0 223 1 1
    TSC2 RPS6KC1 0 0 66 154 1 1
    TSC2 ATG101 0 0 414 525 1 2
    TSC2 TRIB3 0 0 150 225 1 1
    TSC2 PLD2 0 0 158 341 1 1
    TSC2 DEXI 0 0 75 233 1 1
    TSC2 RNF152 0 0 157 156 1 1
    TSC2 GFPT1 0 0 103 185 1 1
    TSC2 ENSG00000160201 0 0 144 180 1 1
    TSC2 ATG4D 0 0 142 205 1 2
    TSC2 CPSF1 0 0 0 215 1 1
    TSC2 SMCO3 0 0 163 163 1 1
    TSC2 GRM1 0 0 123 183 1 1
    TSC2 ENSG00000268643 0 0 0 268 1 1
    TSC2 PRR5L 0 0 320 337 1 1
    TSC2 DIRAS3 0 0 166 303 1 2
    TSC2 KLHL20 0 0 167 190 1 1
    TSC2 CD28 0 0 183 183 1 1
    TSC2 VEGFC 0 0 146 279 1 1
    TSC2 AAK1 0 0 103 234 1 1
    TSC2 TNFRSF10B 0 0 150 165 1 1
    TSC2 SLC1A1 0 0 71 163 1 1
    TSC2 REN 0 0 134 152 1 1
    TSC2 NDE1 0 0 144 199 1 1
    TSC2 ATG12 0 0 506 640 1 2
    TSC2 TNFSF13B 128 0 107 188 1 1
    TSC2 PSMA5 0 0 57 203 1 1
    TSC2 KCNQ3 0 0 135 175 1 1
    TSC2 PPM1B 0 0 103 161 1 1
    TSC2 NOTCH2 0 0 155 183 1 1
    TSC2 IFT88 0 0 157 187 1 1
    TSC2 CLCN7 0 0 51 164 1 1
    TSC2 MAF1 0 0 123 175 1 1
    TSC2 IQSEC2 0 0 139 172 1 1
    TSC2 BNIP3L 0 0 287 315 1 2
    TSC2 TIAM1 0 0 74 176 1 1
    TSC2 ABCD3 0 0 181 220 1 1
    TSC2 RBX1 0 0 309 323 1 1
    TSC2 RAB7B 0 0 342 355 1 1
    TSC2 TRRAP 0 0 148 376 1 1
    TSC2 STAT5B 0 0 206 206 1 1
    TSC2 PPM1D 0 0 194 194 1 1
    TSC2 DDB1 0 0 358 478 1 1
    TSC2 PIK3C2A 0 0 154 387 1 2
    TSC2 VDAC1 0 0 187 187 1 2
    TSC2 RB1 0 0 210 280 1 2
    TSC2 DUSP11 0 0 0 152 1 1
    TSC2 ZFYVE1 0 0 170 169 1 2
    TSC2 BOLA2-SMG1P6 0 0 0 419 1 1
    TSC2 PRKCD 0 0 156 192 1 2
    TSC2 PGP 0 0 413 412 1 1
    TSC2 CDKL5 0 0 346 345 1 1
    TSC2 CDKN1B 486 0 470 764 1 2
    TSC2 FBXL6 213 0 0 213 1 1
    TSC2 HMOX1 0 0 181 181 1 2
    TSC2 FOXP3 0 0 170 190 1 1
    TSC2 ATG2B 0 0 151 227 1 2
    TSC2 TBK1 270 0 167 420 1 2
    TSC2 SEC13 0 0 260 402 1 1
    TSC2 TCHP 0 0 635 635 1 1
    TSC2 ADIPOR2 0 0 155 169 1 1
    TSC2 NRG1 0 0 156 155 1 2
    TSC2 ARHGAP32 0 0 81 259 1 1
    TSC2 DCX 0 0 181 232 1 1
    TSC2 RHOH 0 0 0 198 1 1
    TSC2 RAC2 0 0 706 772 1 1
    TSC2 RAB11A 0 0 123 267 1 1
    TSC2 YY1 0 0 243 264 1 1
    TSC2 STX17 0 0 143 167 1 2
    TSC2 EIF2S1 0 0 394 476 1 2
    TSC2 RASSF1 0 0 171 171 1 1
    TSC2 NTN1 0 0 108 163 1 1
    TSC2 SKP1 0 0 228 234 1 1
    TSC2 KDR 0 0 294 299 1 2
    TSC2 CCZ1 0 0 328 328 1 1
    TSC2 JAK1 0 0 202 227 1 1
    TSC2 MITF 0 0 334 476 1 1
    TSC2 RRAGA 486 900 700 993 1 2
    TSC2 TRIM28 0 0 113 185 1 2
    TSC2 PKD1 0 0 985 988 1 1
    TSC2 RABGEF1 105 0 388 432 1 1
    TSC2 CDKN3 0 0 241 275 1 1
    TSC2 ATG3 0 0 450 522 1 2
    TSC2 VHL 0 0 308 333 1 1
    TSC2 TXNDC9 0 0 986 987 1 1
    TSC2 PSMB5 0 0 60 154 1 1
    TSC2 IQGAP3 0 0 0 225 1 1
    TSC2 MCRS1 0 0 183 222 1 1
    TSC2 FLT1 0 0 184 189 1 1
    TSC2 EIF2AK3 0 0 402 402 1 2
    TSC2 HNF4A 0 0 251 250 1 1
    TSC2 WWP2 0 0 49 174 1 1
    TSC2 RASA3 0 0 0 492 1 1
    TSC2 TEN1-CDK3 0 0 46 227 1 1
    TSC2 ACLY 0 0 340 364 1 1
    TSC2 STAT6 0 0 175 193 1 1
    TSC2 EWSR1 0 0 151 150 1 1
    TSC2 LRPAP1 0 0 261 264 1 1
    TSC2 WDR24 0 0 325 524 1 1
    TSC2 EEA1 0 0 164 163 1 1
    TSC2 IGHMBP2 0 0 0 155 1 1
    TSC2 HSD17B8 0 0 306 306 1 1
    TSC2 SPTAN1 0 0 113 154 1 1
    TSC2 YWHAB 870 900 812 997 1 1
    TSC2 CBFB 270 0 0 375 1 1
    TSC2 PCSK9 0 0 103 159 1 1
    TSC2 OXT 0 0 141 203 1 1
    TSC2 KDM6A 0 0 194 211 1 1
    TSC2 RABEP2 0 0 0 155 1 1
    TSC2 NEK1 192 0 119 257 1 1
    TSC2 SLC2A4 0 0 456 466 1 1
    TSC2 FBXW5 486 0 635 853 1 1
    TSC2 EVA1A 0 0 55 221 1 2
    TSC2 FOXO3 0 0 601 818 1 2
    TSC2 SRC 0 0 452 474 1 1
    TSC2 SCD 0 0 157 156 1 1
    TSC2 RAB25 0 0 46 203 1 2
    TSC2 SMURF2 0 0 55 156 1 1
    TSC2 CDC42 0 0 261 407 1 1
    TSC2 GPN2 0 0 0 198 1 1
    TSC2 IRS4 0 0 108 201 1 1
    TSC2 CRTC1 0 0 112 258 1 1
    TSC2 GRAP 0 0 0 157 1 1
    TSC2 SLK 0 0 287 286 1 1
    TSC2 ATG4C 0 0 318 368 1 2
    TSC2 MKL1 0 0 48 188 1 1
    TSC2 TPM3 0 0 95 167 1 1
    TSC2 CCNE2 0 0 155 173 1 1
    TSC2 MAP3K1 0 0 150 181 1 1
    TSC2 SYNGAP1 0 0 324 355 1 1
    TSC2 CDK15 0 0 56 213 1 1
    TSC2 RIC8A 0 0 74 171 1 1
    TSC2 PKD2 0 0 359 412 1 1
    TSC2 CD34 0 0 195 195 1 1
    TSC2 NGF 0 0 202 202 1 1
    TSC2 HMGA2 0 0 368 368 1 1
    TSC2 HERC1 270 0 391 542 1 1
    TSC2 ERBB2 0 0 468 512 1 2
    TSC2 IRF3 0 0 167 173 1 1
    TSC2 CCZ1B 0 0 328 328 1 1
    TSC2 HBA2 0 0 294 294 1 1
    TSC2 BBC3 0 0 171 171 1 1
    TSC2 VEGFB 0 0 47 196 1 1
    TSC2 FANCD2 0 0 183 187 1 1
    TSC2 FUBP1 0 0 134 200 1 1
    TSC2 WWOX 0 0 137 228 1 1
    TSC2 PHGDH 0 0 171 171 1 1
    TSC2 SLC7A2 0 0 0 213 1 1
    TSC2 CDC16 0 0 324 383 1 1
    TSC2 PINK1 0 0 268 303 1 2
    TSC2 GRM5 0 0 341 386 1 1
    TSC2 GSK3A 0 0 256 435 1 1
    TSC2 SIRT4 0 0 289 304 1 1
    TSC2 SEH1L 0 0 283 406 1 1
    TSC2 PTPN23 0 0 0 165 1 1
    TSC2 FOXO4 0 0 330 360 1 1
    TSC2 AXL 0 0 150 197 1 1
    TSC2 ASPG 0 0 113 177 1 1
    TSC2 HSP90AB1 0 0 66 163 1 2
    TSC2 EIF4EBP1 0 0 856 881 1 1
    TSC2 PIKFYVE 0 0 203 230 1 1
    TSC2 CYLD 0 0 134 227 1 1
    TSC2 KRT18 0 0 264 264 1 1
    TSC2 PMS2 0 0 277 305 1 1
    TSC2 RHOC 0 0 88 271 1 1
    TSC2 SLC36A1 0 0 139 234 1 1
    TSC2 FGFR1 0 0 304 304 1 1
    TSC2 ATP7A 0 0 189 199 1 1
    TSC2 NTRK2 0 0 244 268 1 1
    TSC2 ATF6 0 0 282 282 1 2
    TSC2 IKBKB 0 900 405 946 1 1
    TSC2 TPT1 0 0 388 451 1 1
    TSC2 KLF4 0 0 294 294 1 1
    TSC2 FXR2 0 0 88 199 1 1
    TSC2 E2F4 0 0 144 197 1 1
    TSC2 DISC1 0 0 283 302 1 1
    TSC2 ARF4 0 0 0 198 1 1
    TSC2 NOX4 0 0 174 192 1 1
    TSC2 SDHD 0 0 342 342 1 1
    TSC2 XIAP 0 0 210 219 1 1
    TSC2 VMP1 0 0 231 230 1 2
    TSC2 PPP2R4 0 0 555 615 1 1
    TSC2 KMT2D 0 0 293 298 1 1
    TSC2 CPT1A 0 0 134 168 1 1
    TSC2 CTDP1 270 0 0 333 1 1
    TSC2 AKT1 462 900 903 996 1 2
    TSC2 SLC39A7 116 0 306 360 1 1
    TSC2 ARL5A 0 0 0 198 1 1
    TSC2 UBE3A 486 800 459 945 1 1
    TSC2 RASD2 0 0 112 267 1 1
    TSC2 PPARG 0 0 341 351 1 1
    TSC2 PREX2 0 0 141 181 1 1
    TSC2 MKI67 0 0 57 218 1 1
    TSC2 SGK3 0 0 335 665 1 1
    TSC2 CDK18 0 0 57 220 1 1
    TSC2 FOXA1 0 0 96 247 1 1
    TSC2 CD4 0 0 243 242 1 1
    TSC2 CA9 0 0 217 217 1 1
    TSC2 ATF4 0 0 321 321 1 2
    TSC2 INPP5D 0 0 94 154 1 1
    TSC2 ARL15 0 0 0 198 1 1
    TSC2 USO1 0 0 221 221 1 1
    TSC2 SPPL2B 0 0 45 194 1 1
    TSC2 RCAN1 0 0 56 177 1 2
    TSC2 MUTYH 0 0 262 262 1 1
    TSC2 VCL 0 0 175 175 1 1
    TSC2 GLS2 0 0 285 284 1 1
    TSC2 WIPI2 0 0 256 277 1 2
    TSC2 IDH3A 0 0 0 186 1 1
    TSC2 MAP4K2 0 0 0 228 1 1
    TSC2 CDK3 0 0 46 227 1 1
    TSC2 FMR1 0 0 602 643 1 1
    TSC2 MYO18B 0 0 0 189 1 1
    TSC2 RBFOX3 0 0 242 243 1 1
    TSC2 SLC7A11 0 0 155 196 1 1
    TSC2 ATP11B 0 0 140 168 1 1
    TSC2 RABL2B 0 0 0 198 1 1
    TSC2 IGBP1 0 0 90 311 1 1
    TSC2 CCNT2 0 0 0 163 1 1
    TSC2 PPP1R15A 0 0 289 333 1 2
    TSC2 DDX3X 0 0 83 152 1 1
    TSC2 ITCH 0 0 74 189 1 1
    TSC2 EEF2 0 0 519 652 1 1
    TSC2 FNIP2 0 0 371 371 1 1
    TSC2 OXTR 0 0 181 198 1 1
    TSC2 TNF 0 0 310 322 1 1
    TSC2 NBR1 0 0 269 301 1 2
    TSC2 VPS25 0 0 55 159 1 1
    TSC2 STK32C 0 0 0 323 1 1
    TSC2 YBX1 0 0 146 179 1 1
    TSC2 DNAJC6 0 0 0 237 1 1
    TSC2 PLCB1 0 0 277 341 1 1
    TSC2 LARS 0 0 310 358 1 1
    TSC2 VPS11 0 0 95 159 1 2
    TSC2 PIH1D1 292 0 74 333 1 1
    TSC2 IDH3B 0 0 0 159 1 1
    TSC2 CNPPD1 0 0 0 256 1 1
    TSC2 C22orf29 0 0 212 212 1 1
    TSC2 PAFAH1B1 0 0 270 270 1 1
    TSC2 IL7 0 0 148 166 1 1
    TSC2 SLC1A5 0 0 282 297 1 1
    TSC2 CD44 0 0 219 219 1 1
    TSC2 BDNF 0 0 328 344 1 2
    TSC2 NR4A2 0 0 122 169 1 1
    TSC2 DLGAP2 0 0 164 163 1 1
    TSC2 PIK3R2 0 0 456 498 1 1
    TSC2 WISP1 0 0 155 158 1 1
    TSC2 CASP2 0 0 96 209 1 1
    TSC2 TSHR 0 0 103 195 1 1
    TSC2 ADCY6 0 0 90 162 1 1
    TSC2 PFKFB4 0 0 116 169 1 1
    TSC2 PKM 0 0 320 319 1 1
    TSC2 RAB3GAP1 0 0 90 157 1 1
    TSC2 GADD45A 0 0 167 167 1 1
    TSC2 USP19 0 0 47 157 1 1
    TSC2 PPP2R5C 0 0 0 156 1 1
    TSC2 PPP2R1A 0 0 195 229 1 1
    TSC2 MAPK1 462 900 339 967 1 2
    TSC2 IGF1 0 0 602 612 1 1
    TSC2 WDFY3 0 0 141 173 1 2
    TSC2 PPP2R2B 0 0 73 156 1 1
    TSC2 UVRAG 0 0 470 546 1 2
    TSC2 NEDD4L 0 0 107 222 1 1
    TSC2 RHEBL1 0 0 459 548 1 1
    TSC2 CCND3 270 0 242 527 1 1
    TSC2 ARNTL 0 0 131 199 1 1
    TSC2 LIMD2 0 0 0 179 1 1
    TSC2 RAB39A 0 0 0 203 1 1
    TSC2 BTK 0 0 439 457 1 1
    TSC2 FHIT 0 0 123 216 1 1
    TSC2 WDR45 0 0 167 181 1 2
    TSC2 MAP4K1 0 0 0 222 1 1
    TSC2 RPS6KA2 0 800 558 931 1 1
    TSC2 SOX5 0 0 0 153 1 1
    TSC2 CUL4B 0 0 150 219 1 1
    TSC2 PEX10 0 0 113 150 1 1
    TSC2 CCND2 270 0 282 547 1 1
    TSC2 RHOF 0 0 0 198 1 1
    TSC2 ATG4B 0 0 213 336 1 2
    TSC2 RND3 0 0 66 219 1 1
    TSC2 PIK3C2G 0 0 195 398 1 1
    TSC2 AXIN2 0 0 156 190 1 1
    TSC2 PCDH10 0 0 309 309 1 1
    TSC2 LAMTOR3 0 900 324 929 1 1
    TSC2 ATP12A 0 0 167 173 1 1
    TSC2 PTCH1 0 0 292 292 1 1
    TSC2 GCG 0 0 242 241 1 1
    TSC2 FGF2 0 0 232 231 1 1
    TSC2 RAB7A 0 0 342 387 1 2
    TSC2 DRAM1 0 0 503 507 1 2
    TSC2 CSNK2A1 0 0 108 153 1 1
    TSC2 BCL2A1 0 0 194 194 1 1
    TSC2 CDK17 0 0 54 218 1 1
    TSC2 IQGAP2 0 0 0 221 1 1
    TSC2 RALGAPB 0 0 652 652 1 1
    TSC2 TXNIP 0 0 182 181 1 1
    TSC2 FKBP1C 0 0 63 283 1 1
    TSC2 LAMTOR2 0 900 342 934 1 1
    TSC2 PLEKHA4 270 0 0 270 1 1
    TSC2 SRSF2 0 0 77 162 1 1
    TSC2 TMEM97 0 0 205 238 1 1
    TSC2 ACTN1 0 0 73 166 1 1
    TSC2 MYO18A 0 0 157 287 1 1
    TSC2 BLNK 0 0 77 324 1 1
    TSC2 DVL2 0 0 112 219 1 1
    TSC2 ATR 0 0 161 381 1 1
    TSC2 ARHGEF7 0 0 134 157 1 1
    TSC2 PRKAA1 675 900 340 986 1 2
    TSC2 DDB2 0 0 122 194 1 1
    TSC2 CCND1 486 0 520 774 1 1
    TSC2 SREBF2 0 0 261 354 1 1
    TSC2 CD274 0 0 232 231 1 1
    TSC2 RCC1 0 0 324 329 1 1
    TSC2 TACC3 0 0 668 670 1 1
    TSC2 ARL16 0 0 0 198 1 1
    TSC2 ULK3 0 0 128 344 1 2
    TSC2 NOS3 0 0 246 245 1 1
    TSC2 SEMA3A 0 0 108 163 1 1
    TSC2 PC 0 0 170 169 1 1
    TSC2 BAD 0 0 323 323 1 1
    TSC2 RPS6KB1 0 0 875 954 1 2
    TSC2 RFWD2 0 0 122 154 1 1
    TSC2 YWHAQ 547 900 87 968 1 1
    TSC2 OLIG2 0 0 170 175 1 1
    TSC2 KAT2B 0 0 90 371 1 1
    TSC2 REM1 0 0 0 582 1 1
    TSC2 PGR 0 0 268 279 1 1
    TSC2 CDK1 0 0 656 713 1 1
    TSC2 EIF4E 0 0 710 785 1 1
    TSC2 PRKDC 0 0 166 496 1 2
    TSC2 LEPREL2 0 0 95 151 1 1
    TSC2 PPP2CA 213 0 210 398 1 1
    TSC2 GAMT 0 0 172 171 1 1
    TSC2 IPMK 0 0 171 187 1 1
    TSC2 HMGCR 0 0 278 350 1 1
    TSC2 NTRK1 63 0 304 341 1 1
    TSC2 SESN1 0 0 729 802 1 2
    TSC2 RERGL 0 0 0 198 1 1
    TSC2 KCNA1 0 0 136 155 1 1
    TSC2 CBL 270 0 136 364 1 1
    TSC2 PIK3C2B 0 0 256 478 1 1
    TSC2 SGK1 312 0 560 837 1 1
    TSC2 IRS1 0 0 653 749 1 1
    TSC2 LOX 0 0 212 212 1 1
    TSC2 CC2D1A 0 0 0 179 1 1
    TSC2 RRAD 0 0 95 243 1 1
    TSC2 CCNE1 0 0 218 264 1 1
    TSC2 RASA1 0 0 212 212 1 1
    TSC2 FH 0 0 390 390 1 1
    TSC2 GRIA1 0 0 209 214 1 1
    TSC2 ATG2A 0 0 97 178 1 2
    TSC2 CANX 0 0 155 154 1 2
    TSC2 TXN 0 0 166 165 1 1
    TSC2 INADL 0 0 402 485 1 1
    TSC2 HGF 0 0 218 235 1 1
    TSC2 MAP4K3 0 0 295 439 1 1
    TSC2 POU5F1 270 0 193 408 1 1
    TSC2 SASH1 0 0 81 165 1 1
    TSC2 MKL2 0 0 0 165 1 1
    TSC2 CCNK 0 0 0 193 1 1
    TSC2 PECAM1 0 0 161 161 1 1
    TSC2 CAT 0 0 261 270 1 1
    TSC2 BARD1 0 0 150 155 1 1
    TSC2 DNAJC27 0 0 0 198 1 1
    TSC2 KLC2 0 0 74 158 1 1
    TSC2 MYCBP2 0 0 415 610 1 1
    TSC2 PDPK1 0 650 519 893 1 2
    TSC2 DUSP6 0 0 113 167 1 1
    TSC2 NPFFR2 0 0 95 151 1 1
    TSC2 E2F8 0 0 150 157 1 1
    TSC2 SZT2 0 0 256 366 1 1
    TSC2 GNB2L1 0 0 125 191 1 1
    TSC2 DCLK2 0 0 0 190 1 1
    TSC2 RAB14 0 0 0 198 1 1
    TSC2 TUBA1A 0 0 134 151 1 1
    TSC2 TBC1D17 0 0 661 685 1 1
    TSC2 CTLA4 0 0 234 234 1 1
    TSC2 VPRBP 0 0 122 184 1 1
    TSC2 CLN5 0 0 107 197 1 1
    TSC2 DLGAP3 0 0 193 193 1 1
    TSC2 RRAS2 0 0 81 328 1 1
    TSC2 BCAT2 0 0 173 183 1 1
    TSC2 DDIT4 0 900 876 987 1 1
    TSC2 RHEB 871 900 989 999 1 2
    TSC2 ADD1 0 0 46 168 1 1
    TSC2 MLANA 0 0 325 325 1 1
    TSC2 PHLPP2 0 0 256 369 1 1
    TSC2 MAP2K2 0 0 195 322 1 1
    TSC2 PPP2R5E 0 0 57 158 1 1
    TSC2 MDK 0 0 0 189 1 1
    TSC2 PALLD 0 0 175 231 1 1
    TSC2 FOXA2 0 0 90 242 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005096 Molecular Function GTPase activator activity enables IBA
    GO:0005096 Molecular Function GTPase activator activity enables IDA
    GO:0051879 Molecular Function Hsp90 protein binding enables IPI
    GO:0019902 Molecular Function phosphatase binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0042803 Molecular Function protein homodimerization activity enables IPI
    GO:0031267 Molecular Function small GTPase binding enables IPI
    GO:0043276 Biological Process anoikis involved_in IGI
    GO:0009267 Biological Process cellular response to starvation involved_in IDA
    GO:0006897 Biological Process endocytosis involved_in TAS
    GO:0007507 Biological Process heart development involved_in ISS
    GO:0048009 Biological Process insulin-like growth factor receptor signaling pathway involved_in ISS
    GO:0032007 Biological Process negative regulation of TOR signaling involved_in IBA
    GO:0032007 Biological Process negative regulation of TOR signaling involved_in IDA
    GO:0032007 Biological Process negative regulation of TOR signaling involved_in IGI
    GO:1904262 Biological Process negative regulation of TORC1 signaling involved_in IDA
    GO:0030178 Biological Process negative regulation of Wnt signaling pathway involved_in IBA
    GO:0008285 Biological Process negative regulation of cell population proliferation involved_in ISS
    GO:0046627 Biological Process negative regulation of insulin receptor signaling pathway involved_in IBA
    GO:1901525 Biological Process negative regulation of mitophagy involved_in NAS
    GO:0051898 Biological Process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in IBA
    GO:0051898 Biological Process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in ISS
    GO:0006469 Biological Process negative regulation of protein kinase activity involved_in ISS
    GO:0001843 Biological Process neural tube closure involved_in ISS
    GO:0043491 Biological Process phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in ISS
    GO:0050918 Biological Process positive chemotaxis involved_in ISS
    GO:0016239 Biological Process positive regulation of macroautophagy involved_in IGI
    GO:0006606 Biological Process protein import into nucleus involved_in ISS
    GO:0008104 Biological Process protein localization involved_in ISS
    GO:0051726 Biological Process regulation of cell cycle involved_in IBA
    GO:0030100 Biological Process regulation of endocytosis involved_in ISS
    GO:0046626 Biological Process regulation of insulin receptor signaling pathway involved_in ISS
    GO:0051056 Biological Process regulation of small GTPase mediated signal transduction involved_in IEA
    GO:0016192 Biological Process vesicle-mediated transport involved_in TAS
    GO:0005794 Cellular Component Golgi apparatus NOT located_in IDA
    GO:0005794 Cellular Component Golgi apparatus located_in IDA
    GO:0033596 Cellular Component TSC1-TSC2 complex part_of IBA
    GO:0033596 Cellular Component TSC1-TSC2 complex part_of IDA
    GO:0033596 Cellular Component TSC1-TSC2 complex part_of IPI
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0005737 Cellular Component cytoplasm colocalizes_with IDA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0005765 Cellular Component lysosomal membrane is_active_in IDA
    GO:0005764 Cellular Component lysosome located_in IDA
    GO:0016020 Cellular Component membrane located_in IDA
    GO:0005634 Cellular Component nucleus NOT located_in IDA
    GO:0005634 Cellular Component nucleus located_in IDA
    GO:0048471 Cellular Component perinuclear region of cytoplasm located_in IDA
    GO:0014069 Cellular Component postsynaptic density is_active_in EXP
    GO:0014069 Cellular Component postsynaptic density is_active_in IDA
    Pathways
    Name DB ID
    PIP3 activates AKT signaling Reactome R-HSA-1257604
    Signal Transduction Reactome R-HSA-162582
    Macroautophagy Reactome R-HSA-1632852
    Disease Reactome R-HSA-1643685
    MTOR signalling Reactome R-HSA-165159
    Inhibition of TSC complex formation by PKB Reactome R-HSA-165181
    AKT phosphorylates targets in the cytosol Reactome R-HSA-198323
    Membrane Trafficking Reactome R-HSA-199991
    Generic Transcription Pathway Reactome R-HSA-212436
    PI3K/AKT Signaling in Cancer Reactome R-HSA-2219528
    Transcriptional Regulation by TP53 Reactome R-HSA-3700989
    Energy dependent regulation of mTOR by LKB1-AMPK Reactome R-HSA-380972
    TP53 Regulates Metabolic Genes Reactome R-HSA-5628897
    Vesicle-mediated transport Reactome R-HSA-5653656
    Diseases of signal transduction by growth factor receptors and second messengers Reactome R-HSA-5663202
    Constitutive Signaling by AKT1 E17K in Cancer Reactome R-HSA-5674400
    RNA Polymerase II Transcription Reactome R-HSA-73857
    Gene expression (Transcription) Reactome R-HSA-74160
    TBC/RABGAPs Reactome R-HSA-8854214
    Intracellular signaling by second messengers Reactome R-HSA-9006925
    Rab regulation of trafficking Reactome R-HSA-9007101
    Autophagy Reactome R-HSA-9612973
    p53 transcriptional gene network (WP4963) WikiPathways WP4963_r122690
    Thermogenesis (WP4321) WikiPathways WP4321_r123362
    Fragile X syndrome (WP4549) WikiPathways WP4549_r124287
    Thyroid hormones production and peripheral downstream signaling effects (WP4746) WikiPathways WP4746_r123317
    Glioblastoma signaling pathways (WP2261) WikiPathways WP2261_r123065
    Clear cell renal cell carcinoma pathways (WP4018) WikiPathways WP4018_r123404
    PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (WP3844) WikiPathways WP3844_r107714
    Follicle stimulating hormone (FSH) signaling pathway (WP2035) WikiPathways WP2035_r120721
    DYRK1A (WP5180) WikiPathways WP5180_r122423
    Focal adhesion: PI3K-Akt-mTOR-signaling pathway (WP3932) WikiPathways WP3932_r124527
    Wnt signaling pathway (WP363) WikiPathways WP363_r120695
    Brain-derived neurotrophic factor (BDNF) signaling pathway (WP2380) WikiPathways WP2380_r120727
    Insulin signaling (WP481) WikiPathways WP481_r120562
    BDNF-TrkB signaling (WP3676) WikiPathways WP3676_r116809
    ATM signaling in development and disease (WP3878) WikiPathways WP3878_r123399
    AMP-activated protein kinase signaling (WP1403) WikiPathways WP1403_r123620
    Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway (WP4577) WikiPathways WP4577_r123500
    Head and neck squamous cell carcinoma (WP4674) WikiPathways WP4674_r123494
    Monoamine transport (WP727) WikiPathways WP727_r116775
    PI3K/AKT/mTOR - vitamin D3 signaling (WP4141) WikiPathways WP4141_r122432
    Nanoparticle triggered autophagic cell death (WP2509) WikiPathways WP2509_r101755
    Synaptic signaling pathways associated with autism spectrum disorder (WP4539) WikiPathways WP4539_r113659
    Malignant pleural mesothelioma (WP5087) WikiPathways WP5087_r122659
    PI3K-Akt signaling pathway (WP4172) WikiPathways WP4172_r122580
    T-cell activation SARS-CoV-2 (WP5098) WikiPathways WP5098_r119538
    Angiopoietin-like protein 8 regulatory pathway (WP3915) WikiPathways WP3915_r123920
    Target of rapamycin signaling (WP1471) WikiPathways WP1471_r123616
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_176226 1 miscRNA transcript variant 46 NC_000016 Reference
    NR_176227 1 miscRNA transcript variant 47 NC_000016 Reference
    NR_176225 1 miscRNA transcript variant 45 NC_000016 Reference
    NR_176228 1 miscRNA transcript variant 48 NC_000016 Reference
    NR_176229 1 miscRNA transcript variant 49 NC_000016 Reference
    NM_001406693 1 mRNA transcript variant 39 NC_000016 Reference
    NM_001406667 1 mRNA transcript variant 16 NC_000016 Reference
    NM_001406668 1 mRNA transcript variant 17 NC_000016 Reference
    NM_001406680 1 mRNA transcript variant 26 NC_000016 Reference
    NM_001406683 1 mRNA transcript variant 29 NC_000016 Reference
    NM_001406687 1 mRNA transcript variant 33 NC_000016 Reference
    NM_001406689 1 mRNA transcript variant 35 NC_000016 Reference
    NM_001406690 1 mRNA transcript variant 36 NC_000016 Reference
    NM_001406692 1 mRNA transcript variant 38 NC_000016 Reference
    NM_001406691 1 mRNA transcript variant 37 NC_000016 Reference
    NM_001406697 1 mRNA transcript variant 43 NC_000016 Reference
    NM_001406698 1 mRNA transcript variant 44 NC_000016 Reference
    XM_011522636 3 mRNA transcript variant X1 NC_000016 Reference
    NM_000548 5 mRNA transcript variant 1 NC_000016 Reference
    NM_001114382 3 mRNA transcript variant 5 NC_000016 Reference
    XM_011522637 3 mRNA transcript variant X2 NC_000016 Reference
    NM_001406663 1 mRNA transcript variant 13 NC_000016 Reference
    NM_001406664 1 mRNA transcript variant 14 NC_000016 Reference
    XM_011522639 3 mRNA transcript variant X4 NC_000016 Reference
    NM_021055 3 mRNA transcript variant 2 NC_000016 Reference
    NM_001370405 1 mRNA transcript variant 12 NC_000016 Reference
    NM_001363528 2 mRNA transcript variant 10 NC_000016 Reference
    NM_001406665 1 mRNA transcript variant 15 NC_000016 Reference
    NM_001370404 1 mRNA transcript variant 11 NC_000016 Reference
    NM_001077183 3 mRNA transcript variant 4 NC_000016 Reference
    NM_001406694 1 mRNA transcript variant 40 NC_000016 Reference
    NM_001406695 1 mRNA transcript variant 41 NC_000016 Reference
    NM_001406696 1 mRNA transcript variant 42 NC_000016 Reference
    NM_001406671 1 mRNA transcript variant 19 NC_000016 Reference
    NM_001406673 1 mRNA transcript variant 20 NC_000016 Reference
    NM_001406681 1 mRNA transcript variant 27 NC_000016 Reference
    XM_011522638 3 mRNA transcript variant X3 NC_000016 Reference
    NM_001406670 1 mRNA transcript variant 18 NC_000016 Reference
    NM_001318827 2 mRNA transcript variant 6 NC_000016 Reference
    NM_001406678 1 mRNA transcript variant 24 NC_000016 Reference
    NM_001406682 1 mRNA transcript variant 28 NC_000016 Reference
    NM_001406684 1 mRNA transcript variant 30 NC_000016 Reference
    NM_001406685 1 mRNA transcript variant 31 NC_000016 Reference
    NM_001318831 2 mRNA transcript variant 8 NC_000016 Reference
    NM_001406688 1 mRNA transcript variant 34 NC_000016 Reference
    NM_001406677 1 mRNA transcript variant 23 NC_000016 Reference
    NM_001406675 1 mRNA transcript variant 21 NC_000016 Reference
    NM_001406676 1 mRNA transcript variant 22 NC_000016 Reference
    NM_001318829 2 mRNA transcript variant 7 NC_000016 Reference
    NM_001406679 1 mRNA transcript variant 25 NC_000016 Reference
    NM_001406686 1 mRNA transcript variant 32 NC_000016 Reference
    NM_001318832 2 mRNA transcript variant 9 NC_000016 Reference