TSC1

TSC complex subunit 1
General Information
Name TSC complex subunit 1
Alias
  • hamartin
  • tuberous sclerosis 1 protein
Synonyms KIAA0243 LAM hamartin TSC
Gene_family TSC complex|Armadillo like helical domain containing
organism Homo sapiens
entrez_id 7248
location 9q34
transcript_count 49
exon_count 26
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including TSC2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis. [provided by RefSeq, May 2022]
      Stringdb Hamartin; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling; Armadillo-like helical domain containing
      nextProt In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Seems not to be required for TSC2 GAP activity towards RHEB (PubMed:15340059). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    TSC1 BioGRID PLK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    TSC1 BioGRID XPO7 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID LMNA GeneID BioGRID Cross-Linking-MS (XL-MS)
    TSC1 BioGRID FBXO42 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID FBXO22 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID RPA3 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID Rab18 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID CIAO1 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    TSC1 BioGRID ATG16L1 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID EZH2 GeneID BioGRID Affinity Capture-MS; Negative Genetic
    TSC1 BioGRID USP2-AS1 GeneID BioGRID Protein-RNA
    TSC1 BioGRID TSC2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization; Two-hybrid
    TSC1 BioGRID PIK3C3 GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID RAB25 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID RAB11A GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID CDK1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TSC1 BioGRID CCNB1 GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID TEX14 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID GATA4 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID RAB7A GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID YWHAZ GeneID BioGRID Affinity Capture-MS; Two-hybrid
    TSC1 BioGRID YWHAH GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID YWHAG GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID YWHAE GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID YWHAB GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    TSC1 BioGRID RHOH GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID RHOG GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID FBXW7 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID LURAP1 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID KRT27 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID WHAMMP3 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID NAA40 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID AKTIP GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID TBC1D7 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    TSC1 BioGRID TMED5 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID NPTN GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID YWHAQ GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID KRT38 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID CNTROB GeneID BioGRID Two-hybrid
    TSC1 BioGRID MSANTD3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID LRSAM1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID KLC4 GeneID BioGRID Two-hybrid
    TSC1 BioGRID NKD2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID FBF1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID LZTS2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID BEND5 GeneID BioGRID Two-hybrid
    TSC1 BioGRID GCC1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID COG6 GeneID BioGRID Two-hybrid
    TSC1 BioGRID LUC7L GeneID BioGRID Two-hybrid
    TSC1 BioGRID GPATCH1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID GEMIN8 GeneID BioGRID Two-hybrid
    TSC1 BioGRID KANSL2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID NECAB2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID ANKIB1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID BCL11A GeneID BioGRID Two-hybrid
    TSC1 BioGRID MBIP GeneID BioGRID Two-hybrid
    TSC1 BioGRID CCDC88B GeneID BioGRID Two-hybrid
    TSC1 BioGRID ANKRD24 GeneID BioGRID Two-hybrid
    TSC1 BioGRID ANKRD35 GeneID BioGRID Two-hybrid
    TSC1 BioGRID RALYL GeneID BioGRID Two-hybrid
    TSC1 BioGRID DACH2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID SHANK1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID NRBF2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID SERTAD1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID HOOK2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TFIP11 GeneID BioGRID Two-hybrid
    TSC1 BioGRID KAZN GeneID BioGRID Affinity Capture-Western; Two-hybrid
    TSC1 BioGRID PHLDB1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID ZNF423 GeneID BioGRID Two-hybrid
    TSC1 BioGRID HECW1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID NINL GeneID BioGRID Proximity Label-MS; Two-hybrid
    TSC1 BioGRID SCMH1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID SEC31A GeneID BioGRID Positive Genetic; Two-hybrid
    TSC1 BioGRID CASC3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TRIOBP GeneID BioGRID Two-hybrid
    TSC1 BioGRID CNTRL GeneID BioGRID Two-hybrid
    TSC1 BioGRID RUNDC3A GeneID BioGRID Two-hybrid
    TSC1 BioGRID KIF1C GeneID BioGRID Two-hybrid
    TSC1 BioGRID SPAG5 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TRIM3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID DCTN2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID CALCOCO2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID CNIH1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID SORBS3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TANK GeneID BioGRID Affinity Capture-Western; Two-hybrid
    TSC1 BioGRID ABI1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID PICK1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    TSC1 BioGRID HOMER3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID HGS GeneID BioGRID Two-hybrid
    TSC1 BioGRID KLC1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID KIF5A GeneID BioGRID Two-hybrid
    TSC1 BioGRID ICA1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID GOLGA2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID GFAP GeneID BioGRID Two-hybrid
    TSC1 BioGRID FTH1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    TSC1 BioGRID ATN1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID CTNNB1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID CDR2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID ACTN2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID ACTN1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID EIF3A GeneID BioGRID Two-hybrid
    TSC1 BioGRID PPFIA2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID AXIN1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    TSC1 BioGRID VIM GeneID BioGRID Two-hybrid
    TSC1 BioGRID SELENOW GeneID BioGRID Two-hybrid
    TSC1 BioGRID HNRNPM GeneID BioGRID Two-hybrid
    TSC1 BioGRID ND1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID MBP GeneID BioGRID Two-hybrid
    TSC1 BioGRID SYNE3 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID DERL1 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID LAMTOR1 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID LAMP3 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    TSC1 BioGRID STX6 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID NUP155 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID RAB9A GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID STX7 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID TMOD1 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID RAB5C GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID RAB5A GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID RAB4A GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID RAB2A GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID PFN1 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID LAMP2 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID EGFR GeneID BioGRID Positive Genetic
    TSC1 BioGRID PRC1 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID SREBF1 GeneID BioGRID Negative Genetic
    TSC1 BioGRID FASN GeneID BioGRID Negative Genetic
    TSC1 BioGRID MTCH2 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID GOLGA4 GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID Bex3 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    TSC1 BioGRID VGLL3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID SAMD7 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TSGA10IP GeneID BioGRID Two-hybrid
    TSC1 BioGRID SAXO4 GeneID BioGRID Two-hybrid
    TSC1 BioGRID PATL1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID PPP1R18 GeneID BioGRID Two-hybrid
    TSC1 BioGRID SAMD11 GeneID BioGRID Two-hybrid
    TSC1 BioGRID ZNF417 GeneID BioGRID Two-hybrid
    TSC1 BioGRID MYOZ3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID ZNF765 GeneID BioGRID Two-hybrid
    TSC1 BioGRID IGFN1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID CCDC120 GeneID BioGRID Two-hybrid
    TSC1 BioGRID C1orf94 GeneID BioGRID Two-hybrid
    TSC1 BioGRID ZNF587 GeneID BioGRID Two-hybrid
    TSC1 BioGRID GLIS2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID ENKD1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TFAP2D GeneID BioGRID Two-hybrid
    TSC1 BioGRID YPEL3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID FAM110A GeneID BioGRID Two-hybrid
    TSC1 BioGRID LENG1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID DMRT3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TSHZ3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID CCL28 GeneID BioGRID Two-hybrid
    TSC1 BioGRID SMG9 GeneID BioGRID Two-hybrid
    TSC1 BioGRID HR GeneID BioGRID Two-hybrid
    TSC1 BioGRID FAM222B GeneID BioGRID Two-hybrid
    TSC1 BioGRID VPS37C GeneID BioGRID Two-hybrid
    TSC1 BioGRID SHC3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID CHCHD2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID MYLIP GeneID BioGRID Two-hybrid
    TSC1 BioGRID VENTX GeneID BioGRID Two-hybrid
    TSC1 BioGRID SPAG8 GeneID BioGRID Two-hybrid
    TSC1 BioGRID PATZ1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID POGZ GeneID BioGRID Two-hybrid
    TSC1 BioGRID POU6F2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID RBPMS GeneID BioGRID Two-hybrid
    TSC1 BioGRID ARID5A GeneID BioGRID Two-hybrid
    TSC1 BioGRID FRS3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID RIN1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID BAG3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID FOXH1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID GPANK1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID VEZF1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID ZIC1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TCF7L2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TBX6 GeneID BioGRID Two-hybrid
    TSC1 BioGRID SUOX GeneID BioGRID Two-hybrid
    TSC1 BioGRID ATXN1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID PITX1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID LMO2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID HOXC8 GeneID BioGRID Two-hybrid
    TSC1 BioGRID CSTF2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID AQP1 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TLE5 GeneID BioGRID Two-hybrid
    TSC1 BioGRID LATS2 GeneID BioGRID FRET
    TSC1 BioGRID RASSF1 GeneID BioGRID FRET
    TSC1 BioGRID BECN1 GeneID BioGRID Affinity Capture-MS; FRET
    TSC1 BioGRID TSC1 GeneID BioGRID Affinity Capture-MS; FRET; Two-hybrid
    TSC1 BioGRID AURKA GeneID BioGRID FRET
    TSC1 BioGRID SOX4 GeneID BioGRID FRET
    TSC1 BioGRID MAP2K5 GeneID BioGRID FRET
    TSC1 BioGRID NF2 GeneID BioGRID FRET
    TSC1 BioGRID MYC GeneID BioGRID Affinity Capture-MS; FRET
    TSC1 BioGRID KAT2A GeneID BioGRID FRET
    TSC1 BioGRID FGFR4 GeneID BioGRID FRET
    TSC1 BioGRID DYRK1A GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID MAPK14 GeneID BioGRID Affinity Capture-Western; FRET; Two-hybrid
    TSC1 BioGRID CDKN2B GeneID BioGRID FRET
    TSC1 BioGRID CDKN2A GeneID BioGRID FRET
    TSC1 BioGRID CDK6 GeneID BioGRID FRET
    TSC1 BioGRID CDK4 GeneID BioGRID FRET
    TSC1 BioGRID CCNE1 GeneID BioGRID FRET
    TSC1 BioGRID CCND2 GeneID BioGRID FRET
    TSC1 BioGRID ARAF GeneID BioGRID FRET
    TSC1 BioGRID AKT1 GeneID BioGRID Affinity Capture-Western; FRET
    TSC1 BioGRID RHEB GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    TSC1 BioGRID PLK2 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TSC1 BioGRID TP63 GeneID BioGRID Negative Genetic
    TSC1 BioGRID KRAS GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID TRAPPC2 GeneID BioGRID Positive Genetic
    TSC1 BioGRID IGF2R GeneID BioGRID Positive Genetic
    TSC1 BioGRID IGF1R GeneID BioGRID Positive Genetic
    TSC1 BioGRID HSP90AB1 GeneID BioGRID Negative Genetic
    TSC1 BioGRID B4GALT1 GeneID BioGRID Negative Genetic
    TSC1 BioGRID GCNT2 GeneID BioGRID Positive Genetic
    TSC1 BioGRID ARF1 GeneID BioGRID Negative Genetic
    TSC1 BioGRID VPS53 GeneID BioGRID Positive Genetic
    TSC1 BioGRID TRAPPC2L GeneID BioGRID Negative Genetic
    TSC1 BioGRID TRAPPC12 GeneID BioGRID Positive Genetic
    TSC1 BioGRID SLC39A3 GeneID BioGRID Positive Genetic
    TSC1 BioGRID DAZAP1 GeneID BioGRID Negative Genetic
    TSC1 BioGRID SEC23IP GeneID BioGRID Positive Genetic
    TSC1 BioGRID SEC24A GeneID BioGRID Positive Genetic
    TSC1 BioGRID IGF2BP1 GeneID BioGRID Positive Genetic
    TSC1 BioGRID SEC23B GeneID BioGRID Positive Genetic
    TSC1 BioGRID SEC24B GeneID BioGRID Positive Genetic
    TSC1 BioGRID SEC24C GeneID BioGRID Positive Genetic
    TSC1 BioGRID B4GALT3 GeneID BioGRID Negative Genetic
    TSC1 BioGRID RICTOR GeneID BioGRID Positive Genetic
    TSC1 BioGRID ARFGAP2 GeneID BioGRID Negative Genetic
    TSC1 BioGRID TRAPPC13 GeneID BioGRID Negative Genetic
    TSC1 BioGRID SAR1A GeneID BioGRID Positive Genetic
    TSC1 BioGRID HDAC8 GeneID BioGRID Negative Genetic
    TSC1 BioGRID CUL5 GeneID BioGRID Negative Genetic
    TSC1 BioGRID SLC39A7 GeneID BioGRID Positive Genetic
    TSC1 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID PIH1D1 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID DNAAF10 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID RPAP3 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID CPVL GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID RUVBL2 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID URI1 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID RUVBL1 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID PCM1 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID PPM1H GeneID BioGRID Proximity Label-MS
    TSC1 BioGRID KDM5C GeneID BioGRID Negative Genetic
    TSC1 BioGRID VHL GeneID BioGRID Negative Genetic
    TSC1 BioGRID TOP1 GeneID BioGRID Negative Genetic
    TSC1 BioGRID Tbc1d7 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID Tsc2 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID HSH2D GeneID BioGRID Two-hybrid
    TSC1 BioGRID RIN3 GeneID BioGRID Two-hybrid
    TSC1 BioGRID DOK5 GeneID BioGRID Two-hybrid
    TSC1 BioGRID APPL2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID TNS2 GeneID BioGRID Two-hybrid
    TSC1 BioGRID SH2D2A GeneID BioGRID Two-hybrid
    TSC1 BioGRID RRAGA GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID RRAGC GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID DAPK1 GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID NXF1 GeneID BioGRID Affinity Capture-RNA
    TSC1 BioGRID MOV10 GeneID BioGRID Affinity Capture-RNA
    TSC1 BioGRID PRMT6 GeneID BioGRID Two-hybrid
    TSC1 BioGRID KDM1A GeneID BioGRID Two-hybrid
    TSC1 BioGRID ESR1 GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID IKBKB GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TSC1 Protein NF2 GeneID HPRD None
    TSC1 Protein YWHAG GeneID HPRD None
    TSC1 Protein YWHAE GeneID HPRD None
    TSC1 Protein PLK1 GeneID HPRD None
    TSC1 Protein YWHAB GeneID HPRD None
    TSC1 Protein YWHAZ GeneID HPRD None
    TSC1 Protein MSN GeneID HPRD None
    TSC1 Protein TSC2 GeneID HPRD None
    TSC1 Protein RDX GeneID HPRD None
    TSC1 Protein NEFL GeneID HPRD None
    TSC1 Protein YWHAQ GeneID HPRD None
    TSC1 Protein EZR GeneID HPRD None
    TSC1 Protein CCNB1 GeneID HPRD None
    TSC1 Protein CDK1 GeneID HPRD None
    TSC1 Protein YWHAH GeneID HPRD None
    TSC1 BioGRID FBXW5 GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID EZR GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID Tsc2 GeneID BioGRID Co-localization
    TSC1 BioGRID DOCK7 GeneID BioGRID Affinity Capture-MS
    TSC1 BioGRID RPS6KA1 GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID PTK2 GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID PAM GeneID BioGRID Co-localization
    TSC1 BioGRID NEFL GeneID BioGRID Affinity Capture-Western; Two-hybrid
    TSC1 BioGRID MSN GeneID BioGRID Two-hybrid
    TSC1 BioGRID GSK3B GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID CDKN1B GeneID BioGRID Affinity Capture-Western
    TSC1 BioGRID ACTA1 GeneID BioGRID Co-localization
    TSC1 Protein YWHAB GeneID BIND Hamartin interacts with 14-3-3-beta. This interaction is modeled on demonstrated interaction between human hamartin and mouse 14-3-3-beta isoform.
    TSC1 Protein YWHAG GeneID BIND Hamartin interacts with 14-3-3-gamma. This interaction is modeled on demonstrated interaction between human hamartin and mouse 14-3-3-gamma isoform.
    TSC1 Protein YWHAE GeneID BIND Hamartin interacts with 14-3-3-epsilon.
    TSC1 Protein YWHAH GeneID BIND Hamartin interacts with 14-3-3-eta. This interaction is modeled on demonstrated interaction between human hamartin and mouse 14-3-3-eta isoform.
    TSC1 Protein YWHAQ GeneID BIND Hamartin interacts with 14-3-3-tau. This interaction is modeled on demonstrated interaction between human hamartin and mouse 14-3-3-tau isoform.
    TSC1 Protein MSN GeneID BIND Hamartin interacts with moesin. This interaction was modeled on a demonstrated interaction between murine hamartin and human moesin.
    TSC1 Protein NF2 GeneID BIND Hamartin interacts with Merlin. This interaction was modeled on a demonstrated interaction between human hamartin and moesin from an unspecified species.
    TSC1 Protein NEFL GeneID BIND Hamartin interacts with neurofilament-L.
    TSC1 Protein EZR GeneID BIND Hamartin interacts with ezrin.
    TSC1 Protein TSC2 GeneID BIND Hamartin interacts with tuberin
    TSC1 Protein RDX GeneID BIND Hamartin interacts with radixin. This interaction was modeled on a demonstrated interaction between murine hamartin and human radixin.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TSC1 SDCCAG8 192 0 0 192 1 1
    TSC1 TNS1 0 0 370 518 1 1
    TSC1 CDK11A 0 0 72 190 1 1
    TSC1 SESN2 0 0 419 480 1 2
    TSC1 HSPA6 0 0 0 152 1 1
    TSC1 FXR1 0 0 0 214 1 1
    TSC1 RASA4 0 0 0 324 1 1
    TSC1 RPS6KB2 0 0 416 737 1 2
    TSC1 FKBP1A 0 0 504 556 1 2
    TSC1 SHANK2 0 0 293 386 1 1
    TSC1 URI1 270 0 0 270 1 1
    TSC1 PTK2 270 0 73 294 1 1
    TSC1 RUVBL1 270 0 108 325 1 1
    TSC1 MAPK8 0 0 139 180 1 2
    TSC1 PRKAB1 0 900 188 915 1 2
    TSC1 SKP2 0 0 428 470 1 1
    TSC1 BRAF 0 0 67 241 1 1
    TSC1 PCM1 270 0 81 374 1 1
    TSC1 PLD1 0 0 260 306 1 1
    TSC1 SLC1A2 0 0 138 216 1 1
    TSC1 FLCN 0 0 500 499 1 1
    TSC1 RPS6KA4 0 0 0 180 1 1
    TSC1 SESN3 0 0 181 266 1 1
    TSC1 POMC 0 0 172 171 1 1
    TSC1 CIAO1 270 0 0 275 1 1
    TSC1 PLK2 270 0 486 608 1 1
    TSC1 OGG1 0 0 129 191 1 1
    TSC1 RPS6KA3 0 800 391 900 1 1
    TSC1 RAC3 0 0 0 252 1 1
    TSC1 APPL2 170 0 0 184 1 1
    TSC1 SENP1 0 0 0 195 1 1
    TSC1 RAB8B 0 0 0 457 1 2
    TSC1 PRKAB2 0 900 0 900 1 1
    TSC1 NRXN2 0 0 195 210 1 1
    TSC1 EGF 0 0 240 239 1 1
    TSC1 GAK 0 0 0 307 1 1
    TSC1 FASN 62 0 135 160 1 1
    TSC1 EIF4A3 0 0 45 154 1 1
    TSC1 HSPA4 0 0 118 176 1 1
    TSC1 COL5A1 0 0 386 386 1 1
    TSC1 PIK3R1 0 0 212 279 1 1
    TSC1 RDX 213 0 294 608 1 1
    TSC1 PDCD4 0 0 142 173 1 1
    TSC1 NES 0 0 228 247 1 1
    TSC1 NEK9 0 0 74 189 1 1
    TSC1 RPTOR 0 900 732 989 1 2
    TSC1 BPTF 0 0 0 150 1 1
    TSC1 PPARA 0 0 135 196 1 1
    TSC1 EIF4A1 0 0 271 334 1 1
    TSC1 BAG2 0 540 0 540 1 1
    TSC1 LEPR 0 0 52 150 1 1
    TSC1 ALB 0 0 167 174 1 1
    TSC1 DCLK1 0 0 0 185 1 1
    TSC1 SGK2 0 0 43 416 1 1
    TSC1 CDC37 0 900 0 900 1 1
    TSC1 KAT2A 180 0 0 191 1 1
    TSC1 RAP2A 0 0 242 335 1 1
    TSC1 PSMG2 0 900 0 901 1 1
    TSC1 PVALB 0 0 135 219 1 1
    TSC1 USP28 0 0 0 165 1 1
    TSC1 AGMAT 0 0 70 311 1 1
    TSC1 TPTE 0 0 0 266 1 1
    TSC1 SH3PXD2B 0 0 0 246 1 1
    TSC1 RAP1B 0 0 67 181 1 1
    TSC1 ENSG00000267318 0 0 0 237 1 1
    TSC1 IL4 0 0 94 289 1 1
    TSC1 SEC23B 116 0 0 150 1 2
    TSC1 CDK11B 0 0 71 206 1 1
    TSC1 EPHA4 0 0 0 245 1 1
    TSC1 HLF 0 0 0 189 1 1
    TSC1 AKTIP 342 0 0 342 1 1
    TSC1 YWHAG 171 900 0 928 1 1
    TSC1 NEFL 288 0 662 753 1 1
    TSC1 PIGM 0 0 0 203 1 1
    TSC1 CDK6 129 0 90 195 1 1
    TSC1 SIRT6 0 0 167 186 1 1
    TSC1 RAB9B 0 0 0 160 1 1
    TSC1 MIOS 0 0 236 327 1 1
    TSC1 RERG 0 0 0 158 1 1
    TSC1 SH3PXD2A 0 0 0 298 1 1
    TSC1 RAP2B 0 0 233 327 1 1
    TSC1 CDH1 0 0 135 171 1 1
    TSC1 SLC3A2 0 0 181 181 1 1
    TSC1 BOLA2B 0 0 0 265 1 1
    TSC1 STK32A 0 0 0 237 1 1
    TSC1 CSH1 192 0 0 193 1 1
    TSC1 RHOB 0 0 0 172 1 1
    TSC1 MAP1B 0 0 150 210 1 1
    TSC1 INVS 0 0 180 200 1 1
    TSC1 WNT1 0 0 94 223 1 1
    TSC1 CUL5 129 0 90 207 1 1
    TSC1 PCDH19 0 0 127 163 1 1
    TSC1 RASL12 0 0 0 158 1 1
    TSC1 RPL8 0 0 0 150 1 1
    TSC1 USP6 0 0 479 491 1 1
    TSC1 STK4 0 0 0 231 1 1
    TSC1 GABARAPL1 0 0 166 218 1 2
    TSC1 PDK2 0 0 112 152 1 1
    TSC1 RALB 0 0 113 234 1 1
    TSC1 CCT4 0 900 0 902 1 1
    TSC1 SIRT7 0 0 164 194 1 1
    TSC1 FOXA3 0 0 0 152 1 1
    TSC1 EIF4G1 0 0 342 400 1 2
    TSC1 AR 0 0 113 176 1 1
    TSC1 RHOA 0 0 161 281 1 1
    TSC1 INSR 0 0 75 306 1 1
    TSC1 HSPA8 0 540 48 609 1 2
    TSC1 ATG9A 0 0 84 164 1 2
    TSC1 ERAS 0 0 0 158 1 1
    TSC1 GATSL3 0 0 234 234 1 1
    TSC1 RPAP3 270 0 43 276 1 1
    TSC1 AURKA 187 0 62 204 1 2
    TSC1 SYN1 0 0 233 232 1 1
    TSC1 KCNT1 0 0 95 235 1 1
    TSC1 STUB1 45 540 71 556 1 2
    TSC1 RPS6KA6 0 800 0 843 1 1
    TSC1 FOXG1 0 0 60 190 1 1
    TSC1 RNGTT 0 0 84 194 1 1
    TSC1 MSN 192 0 487 702 1 1
    TSC1 ATG13 0 0 392 507 1 2
    TSC1 INS 0 0 470 470 1 1
    TSC1 ACTB 192 0 235 366 1 1
    TSC1 BNIP3 0 0 218 266 1 2
    TSC1 SQSTM1 0 0 242 299 1 2
    TSC1 DCDC2B 0 0 0 167 1 1
    TSC1 SIRT3 0 0 164 183 1 2
    TSC1 SYDE1 0 0 82 172 1 1
    TSC1 CUL4A 0 0 398 425 1 1
    TSC1 KMT2C 0 0 96 172 1 1
    TSC1 MAPK3 0 900 293 937 1 2
    TSC1 HSP90AA1 0 0 422 445 1 2
    TSC1 TFEB 0 0 390 435 1 2
    TSC1 ASS1 0 0 397 396 1 1
    TSC1 NEK8 0 0 142 201 1 1
    TSC1 BCL2L11 0 0 181 181 1 1
    TSC1 NTHL1 0 0 415 414 1 1
    TSC1 POLDIP3 0 0 203 207 1 1
    TSC1 ARFGEF2 0 0 108 173 1 1
    TSC1 DOK5 170 0 0 169 1 1
    TSC1 DPYSL2 0 0 124 162 1 1
    TSC1 JUN 0 0 147 200 1 1
    TSC1 CCT8 0 900 0 904 1 1
    TSC1 DAPK1 270 0 156 372 1 2
    TSC1 GOLGB1 0 0 415 419 1 1
    TSC1 AKT1S1 0 0 661 661 1 1
    TSC1 NCOA2 0 0 0 357 1 1
    TSC1 EIF2AK1 0 0 81 162 1 1
    TSC1 RASA4B 0 0 0 324 1 1
    TSC1 CCNA2 0 0 307 319 1 1
    TSC1 HSPA1A 0 0 53 173 1 1
    TSC1 ULK2 0 0 260 373 1 2
    TSC1 PIK3CG 0 0 202 383 1 1
    TSC1 RAP2C 0 0 0 158 1 1
    TSC1 MNAT1 192 0 0 202 1 1
    TSC1 IRS2 0 0 294 486 1 1
    TSC1 DEPDC5 0 0 502 502 1 1
    TSC1 RASD1 0 0 71 204 1 1
    TSC1 IL1RAPL2 0 0 0 150 1 1
    TSC1 ENSG00000270024 0 0 103 464 1 1
    TSC1 KIAA0355 0 0 0 215 1 1
    TSC1 ARL10 0 0 54 154 1 1
    TSC1 GRIN2A 0 0 140 193 1 1
    TSC1 YWHAE 668 900 102 975 1 1
    TSC1 LAMP2 0 0 234 234 1 2
    TSC1 SSTR5 0 0 328 328 1 1
    TSC1 ARNT 0 0 119 166 1 2
    TSC1 TBC1D4 0 0 202 202 1 1
    TSC1 GTPBP4 0 0 166 165 1 1
    TSC1 NPRL3 0 0 375 449 1 1
    TSC1 SHH 0 0 143 173 1 1
    TSC1 GRB10 0 0 322 321 1 1
    TSC1 SDHB 0 0 150 173 1 1
    TSC1 ESRRA 0 0 138 199 1 1
    TSC1 TENC1 170 0 0 365 1 1
    TSC1 POMP 0 0 0 150 1 1
    TSC1 HSPA1L 0 0 0 163 1 1
    TSC1 ARF1 115 0 138 293 1 1
    TSC1 CREB1 0 0 154 169 1 1
    TSC1 CRACR2A 0 0 0 436 1 1
    TSC1 USP9X 0 0 63 190 1 1
    TSC1 NLGN3 0 0 359 469 1 1
    TSC1 RAB40B 0 0 0 448 1 1
    TSC1 CCNB1 213 0 137 341 1 1
    TSC1 CNTN1 0 0 0 261 1 1
    TSC1 LAMTOR5 0 900 235 920 1 1
    TSC1 SLC38A9 0 900 340 931 1 1
    TSC1 RAPGEF4 0 0 73 216 1 1
    TSC1 FBXO32 0 0 97 152 1 2
    TSC1 MINPP1 0 0 0 158 1 1
    TSC1 C12orf66 0 0 245 244 1 1
    TSC1 SIRT2 0 0 150 169 1 2
    TSC1 HSF1 0 720 0 722 1 1
    TSC1 IL1RAPL1 0 0 52 262 1 1
    TSC1 PLK1 270 0 937 952 1 1
    TSC1 RELN 0 0 233 263 1 1
    TSC1 PIK3R4 0 0 231 280 1 2
    TSC1 CLDN15 0 0 0 248 1 1
    TSC1 DCDC2C 0 0 0 167 1 1
    TSC1 PHLPP1 0 0 182 181 1 1
    TSC1 KLF6 0 0 0 303 1 1
    TSC1 BBS4 0 0 125 215 1 1
    TSC1 STRADA 0 0 243 374 1 1
    TSC1 PRRC2B 0 0 0 154 1 1
    TSC1 RAB40AL 0 0 183 530 1 1
    TSC1 BCL2L1 0 0 210 210 1 2
    TSC1 CDK10 0 0 0 182 1 1
    TSC1 GAPDH 0 0 194 203 1 2
    TSC1 ATG14 0 0 184 269 1 2
    TSC1 RIT2 0 0 0 158 1 1
    TSC1 LARS2 0 0 261 335 1 1
    TSC1 FKBP8 0 0 439 468 1 1
    TSC1 ARL5B 0 0 56 156 1 1
    TSC1 GABARAPL2 0 0 163 204 1 2
    TSC1 RAP1A 0 0 66 180 1 1
    TSC1 SMG1 0 0 96 337 1 1
    TSC1 BRSK2 0 0 538 538 1 1
    TSC1 RPS6KA5 0 0 0 175 1 1
    TSC1 PRR5 0 900 517 950 1 1
    TSC1 MAP2K7 0 0 325 325 1 1
    TSC1 ABL1 0 0 74 188 1 1
    TSC1 NF1 0 0 469 567 1 1
    TSC1 HIF1A 0 0 341 411 1 2
    TSC1 SIRT5 0 0 164 218 1 1
    TSC1 BAG3 65 720 307 814 1 2
    TSC1 RAB5A 0 0 323 327 1 2
    TSC1 CCT5 0 900 0 902 1 1
    TSC1 CEP128 0 0 77 242 1 1
    TSC1 ATXN1 271 0 54 280 1 1
    TSC1 ARF3 0 0 220 307 1 1
    TSC1 SLC1A7 0 0 228 252 1 1
    TSC1 CDK2 0 0 182 200 1 1
    TSC1 ASTN1 0 0 91 376 1 1
    TSC1 CTNNB1 0 0 291 369 1 1
    TSC1 HRAS 0 0 235 502 1 1
    TSC1 SCN1A 0 0 214 256 1 1
    TSC1 HBA1 192 0 0 192 1 1
    TSC1 PASK 0 0 0 198 1 1
    TSC1 RAB17 0 0 123 221 1 1
    TSC1 DCLK3 0 0 0 158 1 1
    TSC1 CACNA1C 0 0 66 159 1 1
    TSC1 PRKAG1 0 900 87 907 1 1
    TSC1 ENSG00000270249 0 0 0 324 1 1
    TSC1 RRAS 0 0 0 158 1 1
    TSC1 DOHH 0 0 0 179 1 1
    TSC1 ARAF 179 0 92 331 1 1
    TSC1 AK8 0 0 0 252 1 1
    TSC1 NOTCH1 0 0 186 207 1 1
    TSC1 MYO5A 0 0 44 305 1 1
    TSC1 TBR1 0 0 310 309 1 1
    TSC1 MAPKAP1 0 900 391 953 1 1
    TSC1 MTOR 0 900 828 989 1 2
    TSC1 CALM1 0 0 0 157 1 1
    TSC1 RBP7 0 0 0 188 1 1
    TSC1 E2F2 0 0 0 160 1 1
    TSC1 PIK3C3 0 0 358 489 1 2
    TSC1 RAB12 0 0 0 716 1 2
    TSC1 POLR1D 0 0 234 234 1 1
    TSC1 DOCK7 270 0 442 593 1 1
    TSC1 HGFAC 0 0 164 163 1 1
    TSC1 FOXO6 0 0 93 167 1 1
    TSC1 E2F6 0 0 0 150 1 1
    TSC1 PLEK 0 0 369 369 1 1
    TSC1 RPS6 0 0 606 713 1 1
    TSC1 PKHD1 0 0 167 175 1 1
    TSC1 TP53 0 0 362 374 1 2
    TSC1 MDM2 0 0 175 189 1 1
    TSC1 RASEF 0 0 0 436 1 1
    TSC1 ENSG00000273637 0 0 0 190 1 1
    TSC1 LAMP1 0 0 134 158 1 2
    TSC1 SLC2A1 0 0 245 259 1 1
    TSC1 HTT 0 0 172 193 1 1
    TSC1 CDK4 129 0 166 263 1 1
    TSC1 EGFR 0 0 310 353 1 1
    TSC1 RAF1 0 0 164 301 1 2
    TSC1 HK2 0 0 156 155 1 1
    TSC1 NRXN3 0 0 181 186 1 1
    TSC1 RBL1 0 0 45 157 1 1
    TSC1 SLC7A5 0 0 231 236 1 1
    TSC1 TNS3 0 0 0 270 1 1
    TSC1 PAM 273 0 0 273 1 1
    TSC1 EMX1 0 0 217 231 1 1
    TSC1 RAB10 0 0 167 510 1 1
    TSC1 NGFRAP1 270 0 887 925 1 1
    TSC1 DIRAS1 0 0 0 158 1 1
    TSC1 FNTA 0 0 430 430 1 1
    TSC1 NLGN1 0 0 247 294 1 1
    TSC1 CALM3 0 0 0 157 1 1
    TSC1 CAMKK2 0 0 291 290 1 2
    TSC1 NPRL2 0 0 391 414 1 1
    TSC1 SFPQ 192 0 0 211 1 1
    TSC1 NLGN4X 0 0 321 438 1 1
    TSC1 LAMTOR4 0 900 322 929 1 1
    TSC1 SOX4 185 0 0 185 1 1
    TSC1 RAB8A 0 0 66 471 1 2
    TSC1 UBR5 0 0 0 166 1 1
    TSC1 NF2 402 0 490 739 1 1
    TSC1 EIF2AK4 0 0 235 305 1 1
    TSC1 STAT3 0 0 194 194 1 2
    TSC1 CPVL 270 0 0 270 1 1
    TSC1 ARL8B 0 0 109 203 1 1
    TSC1 MYC 170 0 323 427 1 2
    TSC1 PPP5C 0 900 0 905 1 1
    TSC1 RAB11FIP5 192 0 0 209 1 1
    TSC1 STK32B 0 0 0 237 1 1
    TSC1 STEAP3 0 0 536 536 1 1
    TSC1 IFT20 0 0 125 165 1 1
    TSC1 NLGN2 0 0 187 237 1 1
    TSC1 IGF1R 105 0 293 505 1 1
    TSC1 KIF21A 0 0 134 153 1 1
    TSC1 RASAL1 0 0 0 333 1 1
    TSC1 PI3 0 0 154 153 1 1
    TSC1 PPARGC1A 0 0 216 232 1 1
    TSC1 RIT1 0 0 0 158 1 1
    TSC1 MEN1 0 0 181 221 1 1
    TSC1 RICTOR 129 900 720 984 1 2
    TSC1 WDR64 0 0 0 199 1 1
    TSC1 RUVBL2 270 0 0 275 1 1
    TSC1 PIK3R3 0 0 137 210 1 1
    TSC1 STRN4 0 0 0 210 1 1
    TSC1 SCN2A 0 0 113 171 1 1
    TSC1 PIK3CA 0 0 386 527 1 2
    TSC1 VAPA 0 0 0 150 1 1
    TSC1 TOP1 220 0 0 220 1 1
    TSC1 ITFG2 0 0 164 163 1 1
    TSC1 SPATA6L 0 0 204 204 1 1
    TSC1 RP1L1 0 0 0 167 1 1
    TSC1 MAU2 0 0 0 217 1 1
    TSC1 CCNT1 0 0 0 161 1 1
    TSC1 EIF5B 0 0 143 158 1 1
    TSC1 CYFIP1 0 0 208 250 1 1
    TSC1 SHANK1 0 0 263 400 1 1
    TSC1 ACTA1 273 0 0 277 1 1
    TSC1 EFNA5 0 0 392 392 1 1
    TSC1 NGDN 0 0 369 393 1 1
    TSC1 WDR62 0 0 95 192 1 1
    TSC1 MECP2 0 0 293 341 1 1
    TSC1 CAB39 0 0 157 156 1 1
    TSC1 RB1CC1 0 0 618 772 1 2
    TSC1 MAP2K5 142 0 0 195 1 1
    TSC1 AKT2 0 900 325 964 1 1
    TSC1 RSG1 0 0 0 158 1 1
    TSC1 STK11 0 0 596 687 1 2
    TSC1 MAP2K1 0 0 218 288 1 1
    TSC1 MAGI1 481 0 0 481 1 1
    TSC1 BOLA2 0 0 0 265 1 1
    TSC1 MAP1LC3B 0 0 162 182 1 2
    TSC1 PIGA 0 0 0 190 1 1
    TSC1 KPTN 0 0 218 218 1 1
    TSC1 RIN3 170 0 0 184 1 1
    TSC1 ESPN 0 0 0 150 1 1
    TSC1 ATG10 0 0 125 189 1 2
    TSC1 IPO4 0 0 0 186 1 1
    TSC1 DYRK1A 675 0 112 713 1 1
    TSC1 FNIP1 0 0 341 341 1 1
    TSC1 RALA 0 0 181 293 1 1
    TSC1 GEM 0 0 0 158 1 1
    TSC1 AKT3 0 800 367 933 1 1
    TSC1 RASL11B 0 0 0 158 1 1
    TSC1 RPS6KA1 270 900 562 972 1 1
    TSC1 NR2E3 0 0 0 173 1 1
    TSC1 PRKCA 0 0 325 345 1 1
    TSC1 SETD2 0 0 113 161 1 1
    TSC1 RASL10A 0 0 0 158 1 1
    TSC1 ULK1 0 0 425 513 1 2
    TSC1 SYDE2 0 0 108 310 1 1
    TSC1 SENP3 0 0 0 151 1 1
    TSC1 RAB13 0 0 0 450 1 2
    TSC1 ESR1 270 0 416 598 1 1
    TSC1 RAC1 0 0 49 219 1 1
    TSC1 PPP1CA 0 0 0 185 1 1
    TSC1 KIF3A 0 0 127 163 1 1
    TSC1 SIRT1 0 0 216 267 1 2
    TSC1 DDIT4L 0 0 241 275 1 1
    TSC1 NUAK1 0 0 52 219 1 1
    TSC1 EOMES 0 0 411 410 1 1
    TSC1 TP63 209 0 0 209 1 2
    TSC1 PUM1 0 0 54 152 1 1
    TSC1 PRKAG2 0 900 46 903 1 1
    TSC1 CNTNAP2 0 0 287 365 1 1
    TSC1 TEX37 0 0 277 277 1 1
    TSC1 ATG5 0 0 268 346 1 2
    TSC1 RAB15 0 0 0 436 1 1
    TSC1 PRKD1 0 0 307 307 1 1
    TSC1 WIPI1 0 0 170 184 1 2
    TSC1 PI4KB 0 0 0 176 1 1
    TSC1 RRAGB 0 900 500 964 1 2
    TSC1 TELO2 0 0 81 170 1 1
    TSC1 PRKAA2 0 900 297 943 1 2
    TSC1 E2F5 0 0 0 193 1 1
    TSC1 KDM5C 234 0 71 284 1 1
    TSC1 VEGFA 0 0 283 282 1 1
    TSC1 GABARAP 0 0 150 204 1 2
    TSC1 PTEN 0 0 603 864 1 2
    TSC1 ID3 192 0 0 192 1 1
    TSC1 EIF4EBP3 0 0 309 428 1 1
    TSC1 CNTN2 0 0 56 563 1 1
    TSC1 MAPK14 446 0 95 509 1 1
    TSC1 MARK2 0 0 150 183 1 1
    TSC1 E2F3 0 0 0 162 1 1
    TSC1 NGFR 270 0 70 336 1 1
    TSC1 SREBF1 62 0 261 326 1 2
    TSC1 SLC36A4 0 0 321 321 1 1
    TSC1 KATNAL2 0 0 70 375 1 1
    TSC1 AMBRA1 0 0 193 210 1 2
    TSC1 ASTN2 0 0 0 189 1 1
    TSC1 KIT 0 0 165 165 1 1
    TSC1 NRXN1 0 0 289 293 1 1
    TSC1 DIRAS2 0 0 0 158 1 1
    TSC1 TTI1 0 0 340 348 1 1
    TSC1 IGF2 0 0 156 155 1 1
    TSC1 EIF3F 192 0 74 220 1 1
    TSC1 AXIN1 270 0 175 399 1 1
    TSC1 RAP1GAP 0 0 430 430 1 1
    TSC1 EZR 270 0 896 946 1 1
    TSC1 ATM 0 0 233 250 1 1
    TSC1 DAP 0 0 206 206 1 2
    TSC1 PRKAG3 0 900 0 901 1 1
    TSC1 MRAS 0 0 0 158 1 1
    TSC1 GFAP 0 0 193 193 1 2
    TSC1 FGFR4 187 0 0 187 1 1
    TSC1 RXRG 94 0 0 190 1 1
    TSC1 USP34 0 0 0 164 1 1
    TSC1 ATG7 0 0 246 366 1 2
    TSC1 PREX1 0 0 163 178 1 1
    TSC1 DLG4 0 0 234 286 1 1
    TSC1 AK1 0 0 328 328 1 1
    TSC1 PI4KA 0 0 0 175 1 1
    TSC1 CHD8 0 0 195 268 1 1
    TSC1 RASA2 0 0 0 539 1 1
    TSC1 TBC1D7 974 800 970 999 1 2
    TSC1 ATG16L1 0 0 141 196 1 2
    TSC1 PIK3CD 0 0 166 357 1 1
    TSC1 INPP4B 0 0 189 189 1 1
    TSC1 C6orf106 0 0 0 167 1 1
    TSC1 YWHAH 451 900 0 952 1 1
    TSC1 LAMTOR1 0 900 325 932 1 1
    TSC1 WDR92 270 0 0 270 1 1
    TSC1 PTGES3 0 900 0 900 1 1
    TSC1 SST 0 0 155 154 1 1
    TSC1 CALM2 0 0 0 157 1 1
    TSC1 KCNQ2 0 0 81 183 1 1
    TSC1 CDKN2A 130 0 210 294 1 2
    TSC1 SFN 0 900 123 921 1 1
    TSC1 PBRM1 0 0 193 231 1 1
    TSC1 GSK3B 270 900 446 963 1 2
    TSC1 INSRR 0 0 0 281 1 1
    TSC1 RBL2 0 0 0 154 1 1
    TSC1 RIN1 76 0 90 178 1 1
    TSC1 CHUK 0 0 148 279 1 1
    TSC1 CUL3 0 0 108 155 1 1
    TSC1 RASSF7 192 0 68 336 1 1
    TSC1 KCNQ3 0 0 56 161 1 1
    TSC1 KIF2A 0 0 155 173 1 1
    TSC1 DCDC2 0 0 49 189 1 1
    TSC1 ATG12 0 0 212 285 1 2
    TSC1 KLHL20 94 0 112 167 1 1
    TSC1 NR2C2 0 0 0 178 1 1
    TSC1 ENSG00000268643 0 0 0 180 1 1
    TSC1 PRR5L 0 0 205 205 1 1
    TSC1 DIRAS3 0 0 0 158 1 2
    TSC1 CNTN5 0 0 0 195 1 1
    TSC1 GRM1 0 0 88 150 1 1
    TSC1 PSMG1 0 900 0 900 1 1
    TSC1 RNF152 0 0 214 227 1 1
    TSC1 HSPA1B 0 0 0 163 1 1
    TSC1 ATG101 0 0 163 188 1 2
    TSC1 HSPB8 0 720 0 720 1 2
    TSC1 GABRB3 0 0 195 225 1 1
    TSC1 EIF4B 0 0 382 433 1 1
    TSC1 MYO5B 0 0 0 189 1 1
    TSC1 FIGF 0 0 252 252 1 1
    TSC1 FBXO45 0 0 82 179 1 1
    TSC1 MKS1 0 0 99 258 1 1
    TSC1 CNTN3 0 0 0 195 1 1
    TSC1 CASP3 0 0 182 187 1 2
    TSC1 ERBB3 0 0 94 150 1 1
    TSC1 RRAGD 0 900 420 948 1 1
    TSC1 RASL10B 0 0 0 158 1 1
    TSC1 REM2 0 0 0 158 1 1
    TSC1 SCN8A 0 0 97 163 1 1
    TSC1 CCT6B 0 540 0 548 1 1
    TSC1 LPIN1 0 0 242 289 1 2
    TSC1 NUAK2 0 0 84 246 1 1
    TSC1 BECN1 270 0 320 538 1 2
    TSC1 RASL11A 0 0 0 158 1 1
    TSC1 EIF4EBP2 0 0 403 727 1 1
    TSC1 EEF2K 0 0 293 293 1 2
    TSC1 CDKN2B 145 0 61 175 1 1
    TSC1 PIK3CB 0 0 210 391 1 1
    TSC1 CCT8L2 0 540 0 556 1 1
    TSC1 MET 0 0 151 183 1 1
    TSC1 GRIN2B 0 0 128 158 1 1
    TSC1 HSH2D 170 0 0 169 1 1
    TSC1 CAD 0 0 181 233 1 1
    TSC1 FOXP2 0 0 113 165 1 1
    TSC1 TFE3 0 0 340 422 1 1
    TSC1 E2F1 0 0 0 156 1 1
    TSC1 NRAS 0 0 94 299 1 1
    TSC1 MLST8 0 900 681 973 1 2
    TSC1 EIF4A2 0 0 282 343 1 1
    TSC1 FTH1 192 0 0 192 1 1
    TSC1 KRAS 169 0 210 535 1 1
    TSC1 TPTE2 0 0 0 266 1 1
    TSC1 FOXO1 0 0 336 403 1 2
    TSC1 LGI1 0 0 124 207 1 1
    TSC1 YWHAZ 192 900 95 938 1 1
    TSC1 CCT7 0 900 0 902 1 1
    TSC1 WDR59 0 0 235 244 1 1
    TSC1 RXRA 0 0 0 156 1 1
    TSC1 TCEB1 0 0 179 195 1 1
    TSC1 RRAGC 270 900 544 969 1 1
    TSC1 DEPTOR 0 900 603 958 1 1
    TSC1 RAB11B 94 0 0 190 1 1
    TSC1 EIF4EBP1 0 0 687 741 1 1
    TSC1 RHOC 0 0 0 178 1 1
    TSC1 FOXO4 0 0 193 259 1 1
    TSC1 HSP90AB1 116 720 0 791 1 2
    TSC1 SEH1L 0 0 181 278 1 1
    TSC1 SIRT4 0 0 211 229 1 1
    TSC1 BEND2 0 0 204 204 1 1
    TSC1 FOXH1 76 0 0 151 1 1
    TSC1 GRM5 0 0 236 288 1 1
    TSC1 GSK3A 0 0 74 209 1 1
    TSC1 CDC16 0 0 319 351 1 1
    TSC1 HERC1 0 0 143 241 1 1
    TSC1 ERBB2 0 0 211 260 1 2
    TSC1 PKD2 0 0 227 236 1 1
    TSC1 NDUFB10 192 0 0 192 1 1
    TSC1 SYNGAP1 0 0 181 303 1 1
    TSC1 IGF2R 115 0 0 154 1 1
    TSC1 ATF4 0 0 163 163 1 2
    TSC1 RAB40C 0 0 0 448 1 1
    TSC1 ALS2 0 0 61 574 1 1
    TSC1 FOXA1 0 0 0 175 1 1
    TSC1 SGK3 0 0 113 470 1 1
    TSC1 PREX2 0 0 162 176 1 1
    TSC1 UBE3A 0 800 243 871 1 1
    TSC1 RASD2 0 0 74 242 1 1
    TSC1 PPARG 0 0 181 239 1 1
    TSC1 AKT1 640 900 872 997 1 2
    TSC1 KMT2D 0 0 86 164 1 1
    TSC1 HECTD4 0 0 0 191 1 1
    TSC1 PPP2R4 0 0 231 230 1 1
    TSC1 SDHD 0 0 138 156 1 1
    TSC1 E2F4 0 0 0 193 1 1
    TSC1 DISC1 68 0 124 220 1 1
    TSC1 TPT1 0 0 641 703 1 1
    TSC1 FXR2 0 0 46 227 1 1
    TSC1 IKBKB 270 900 297 952 1 1
    TSC1 NTRK2 0 0 167 199 1 1
    TSC1 SLC36A1 0 0 308 307 1 1
    TSC1 RRAGA 270 900 469 971 1 2
    TSC1 MITF 0 0 170 292 1 1
    TSC1 EIF2S1 0 0 167 230 1 2
    TSC1 RASSF1 130 0 57 198 1 1
    TSC1 RAC2 0 0 519 625 1 1
    TSC1 RAB11A 0 0 46 151 1 1
    TSC1 DCX 0 0 137 280 1 1
    TSC1 SEC13 0 0 170 196 1 1
    TSC1 TCHP 0 0 293 293 1 1
    TSC1 CDKL5 0 0 150 191 1 1
    TSC1 STK3 0 0 0 231 1 1
    TSC1 CDKN1B 270 0 300 467 1 2
    TSC1 BOLA2-SMG1P6 0 0 0 284 1 1
    TSC1 USP7 0 0 0 233 1 1
    TSC1 GPATCH8 0 0 0 189 1 1
    TSC1 RB1 0 0 47 183 1 2
    TSC1 CCDC120 83 0 0 153 1 1
    TSC1 RAB7B 0 0 171 219 1 1
    TSC1 RBX1 0 0 388 407 1 1
    TSC1 TRRAP 0 0 108 235 1 1
    TSC1 TSC2 913 900 990 999 1 2
    TSC1 RAB28 0 0 0 941 1 1
    TSC1 DDB1 0 0 415 418 1 1
    TSC1 PIK3C2A 0 0 107 296 1 2
    TSC1 IFT88 0 0 123 163 1 1
    TSC1 IRS4 0 0 0 177 1 1
    TSC1 CRTC1 0 0 0 158 1 1
    TSC1 CDC42 0 0 137 291 1 1
    TSC1 SRC 0 0 194 231 1 1
    TSC1 SLC2A4 0 0 183 198 1 1
    TSC1 FBXW5 270 0 575 687 1 1
    TSC1 FOXO3 0 0 325 732 1 2
    TSC1 YWHAB 422 900 306 966 1 1
    TSC1 CCT3 0 900 0 907 1 1
    TSC1 WDR24 0 0 245 343 1 1
    TSC1 ACLY 0 0 161 187 1 1
    TSC1 EIF2AK3 0 0 141 151 1 2
    TSC1 RASA3 0 0 0 539 1 1
    TSC1 VHL 176 0 184 298 1 1
    TSC1 TXNDC9 0 0 283 283 1 1
    TSC1 ATG3 0 0 163 216 1 2
    TSC1 PKD1 0 0 515 520 1 1
    TSC1 CDKN3 0 0 112 312 1 1
    TSC1 LOX 0 0 124 154 1 1
    TSC1 RRAD 0 0 0 158 1 1
    TSC1 RERGL 0 0 0 158 1 1
    TSC1 PIK3C2B 0 0 124 287 1 1
    TSC1 IRS1 0 0 468 696 1 1
    TSC1 SGK1 0 0 414 642 1 1
    TSC1 SESN1 0 0 271 347 1 2
    TSC1 NTRK1 0 0 144 177 1 1
    TSC1 PRKDC 0 0 57 278 1 2
    TSC1 SPG11 0 0 58 380 1 1
    TSC1 PGR 0 0 124 186 1 1
    TSC1 CDK1 462 0 185 558 1 1
    TSC1 EIF4E 0 0 601 655 1 1
    TSC1 YWHAQ 370 900 66 949 1 1
    TSC1 REM1 0 0 0 454 1 1
    TSC1 PGC 0 0 0 164 1 1
    TSC1 RPS6KB1 0 0 705 867 1 2
    TSC1 ACTA2 192 0 0 197 1 1
    TSC1 ARL16 0 0 54 154 1 1
    TSC1 CCND1 0 0 261 331 1 1
    TSC1 SREBF2 0 0 134 193 1 1
    TSC1 RAB44 0 0 0 436 1 1
    TSC1 PRKAA1 0 900 125 930 1 2
    TSC1 ATR 0 0 54 195 1 1
    TSC1 CNTN6 0 0 50 202 1 1
    TSC1 SLC35A2 0 0 0 190 1 1
    TSC1 MDK 0 0 0 190 1 1
    TSC1 FOXA2 0 0 0 175 1 1
    TSC1 MLANA 0 0 218 218 1 1
    TSC1 CNTN4 0 0 0 195 1 1
    TSC1 SSH3 0 0 0 156 1 1
    TSC1 DDIT4 0 900 761 975 1 1
    TSC1 RHEB 487 900 964 999 1 2
    TSC1 DLGAP3 0 0 208 219 1 1
    TSC1 RRAS2 0 0 0 234 1 1
    TSC1 TBC1D17 0 0 143 185 1 1
    TSC1 RAB14 0 0 0 194 1 1
    TSC1 SH2D2A 170 0 0 169 1 1
    TSC1 SZT2 0 0 213 213 1 1
    TSC1 GNB2L1 0 0 90 151 1 1
    TSC1 DCLK2 0 0 0 158 1 1
    TSC1 PDPK1 0 0 321 582 1 2
    TSC1 MYCBP2 0 0 91 330 1 1
    TSC1 CLDN14 0 0 0 179 1 1
    TSC1 MAP4K3 0 0 263 340 1 1
    TSC1 GRIA1 0 0 142 179 1 1
    TSC1 CCT6A 0 900 0 902 1 1
    TSC1 CCNE1 181 0 43 224 1 1
    TSC1 RASA1 192 0 53 227 1 1
    TSC1 FH 0 0 234 234 1 1
    TSC1 TMEM71 0 0 155 154 1 1
    TSC1 PIK3R2 0 0 214 296 1 1
    TSC1 WISP1 0 0 170 172 1 1
    TSC1 STRN3 0 0 0 282 1 1
    TSC1 SLC1A5 0 0 161 188 1 1
    TSC1 BDNF 0 0 233 245 1 2
    TSC1 HERC2 0 0 0 192 1 1
    TSC1 HSPA2 0 0 0 163 1 1
    TSC1 PAFAH1B1 0 0 124 160 1 1
    TSC1 LARS 0 0 264 280 1 1
    TSC1 PIH1D1 553 0 47 579 1 1
    TSC1 NBR1 0 0 0 234 1 2
    TSC1 PRC1 270 0 0 273 1 1
    TSC1 STK32C 0 0 0 237 1 1
    TSC1 DNAJC6 0 0 0 266 1 1
    TSC1 TNF 0 0 136 232 1 1
    TSC1 EEF2 0 0 284 368 1 1
    TSC1 FNIP2 0 0 204 209 1 1
    TSC1 PPP1R15A 0 0 450 488 1 2
    TSC1 FMR1 0 0 458 553 1 1
    TSC1 STIP1 0 900 0 900 1 1
    TSC1 RBFOX3 0 0 181 181 1 1
    TSC1 RP1 0 0 0 168 1 1
    TSC1 RALGAPB 0 0 204 299 1 1
    TSC1 RAB40A 0 0 0 448 1 1
    TSC1 FKBP1C 0 0 54 154 1 1
    TSC1 LAMTOR2 0 900 247 923 1 1
    TSC1 KMT2A 0 0 0 183 1 1
    TSC1 RAB7A 0 0 170 246 1 2
    TSC1 PIK3C2G 0 0 82 222 1 1
    TSC1 PCDH10 0 0 139 191 1 1
    TSC1 LAMTOR3 0 900 261 922 1 1
    TSC1 PTCH1 0 0 124 154 1 1
    TSC1 ARX 0 0 113 153 1 1
    TSC1 TCP1 0 900 55 903 1 1
    TSC1 CCND2 142 0 134 322 1 1
    TSC1 CD63 192 0 0 192 1 1
    TSC1 RPS6KA2 0 800 391 900 1 1
    TSC1 RAB39A 0 0 0 170 1 1
    TSC1 RHEBL1 0 0 337 418 1 1
    TSC1 CCND3 0 0 81 195 1 1
    TSC1 UVRAG 0 0 215 257 1 2
    TSC1 STRN 0 0 56 417 1 1
    TSC1 MAPK1 0 900 113 921 1 2
    TSC1 IGF1 0 0 454 454 1 1
    TSC1 CCT2 0 900 0 902 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0042030 Molecular Function ATPase inhibitor activity enables IDA
    GO:0030544 Molecular Function Hsp70 protein binding enables IDA
    GO:0051879 Molecular Function Hsp90 protein binding enables IPI
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0044183 Molecular Function protein folding chaperone enables IDA
    GO:0051087 Molecular Function protein-folding chaperone binding enables IPI
    GO:0046323 Biological Process D-glucose import involved_in IEA
    GO:0090630 Biological Process activation of GTPase activity involved_in IDA
    GO:0002250 Biological Process adaptive immune response involved_in IEA
    GO:0008344 Biological Process adult locomotory behavior involved_in ISS
    GO:0008306 Biological Process associative learning involved_in IEA
    GO:0055007 Biological Process cardiac muscle cell differentiation involved_in IEA
    GO:0008283 Biological Process cell population proliferation involved_in IEA
    GO:0030030 Biological Process cell projection organization involved_in IEA
    GO:0007160 Biological Process cell-matrix adhesion involved_in IMP
    GO:0036294 Biological Process cellular response to decreased oxygen levels involved_in ISS
    GO:0009267 Biological Process cellular response to starvation involved_in IDA
    GO:0021987 Biological Process cerebral cortex development involved_in IEA
    GO:0021766 Biological Process hippocampus development involved_in IEA
    GO:0001822 Biological Process kidney development involved_in IEA
    GO:0043379 Biological Process memory T cell differentiation involved_in IEA
    GO:0042552 Biological Process myelination involved_in IEA
    GO:0032780 Biological Process negative regulation of ATP-dependent activity involved_in IDA
    GO:0032007 Biological Process negative regulation of TOR signaling involved_in IBA
    GO:0032007 Biological Process negative regulation of TOR signaling involved_in IDA
    GO:0032007 Biological Process negative regulation of TOR signaling involved_in IMP
    GO:0032007 Biological Process negative regulation of TOR signaling involved_in ISS
    GO:1904262 Biological Process negative regulation of TORC1 signaling involved_in IDA
    GO:0008285 Biological Process negative regulation of cell population proliferation involved_in IBA
    GO:0008285 Biological Process negative regulation of cell population proliferation involved_in IMP
    GO:0045792 Biological Process negative regulation of cell size involved_in IEA
    GO:0016242 Biological Process negative regulation of macroautophagy involved_in ISS
    GO:0001843 Biological Process neural tube closure involved_in IEA
    GO:0051894 Biological Process positive regulation of focal adhesion assembly involved_in IDA
    GO:0006813 Biological Process potassium ion transport involved_in IEA
    GO:0006457 Biological Process protein folding involved_in IEA
    GO:0050821 Biological Process protein stabilization involved_in IDA
    GO:0050821 Biological Process protein stabilization involved_in IMP
    GO:0051726 Biological Process regulation of cell cycle involved_in IBA
    GO:0001952 Biological Process regulation of cell-matrix adhesion involved_in IMP
    GO:0051492 Biological Process regulation of stress fiber assembly involved_in IDA
    GO:0032868 Biological Process response to insulin involved_in IDA
    GO:0050808 Biological Process synapse organization involved_in IEA
    GO:0033596 Cellular Component TSC1-TSC2 complex part_of EXP
    GO:0033596 Cellular Component TSC1-TSC2 complex part_of IBA
    GO:0033596 Cellular Component TSC1-TSC2 complex part_of IDA
    GO:0033596 Cellular Component TSC1-TSC2 complex part_of IPI
    GO:0005884 Cellular Component actin filament colocalizes_with IDA
    GO:0005938 Cellular Component cell cortex located_in IDA
    GO:0036064 Cellular Component ciliary basal body located_in IDA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0030027 Cellular Component lamellipodium located_in IDA
    GO:0005811 Cellular Component lipid droplet located_in IDA
    GO:0005765 Cellular Component lysosomal membrane is_active_in IDA
    GO:0016020 Cellular Component membrane located_in IDA
    GO:0005634 Cellular Component nucleus located_in ISS
    GO:0048471 Cellular Component perinuclear region of cytoplasm located_in ISS
    GO:0005886 Cellular Component plasma membrane located_in TAS
    GO:0014069 Cellular Component postsynaptic density located_in IEA
    GO:0101031 Cellular Component protein folding chaperone complex part_of IDA
    GO:0032991 Cellular Component protein-containing complex part_of IDA
    Pathways
    Name DB ID
    Signal Transduction Reactome R-HSA-162582
    Macroautophagy Reactome R-HSA-1632852
    MTOR signalling Reactome R-HSA-165159
    Inhibition of TSC complex formation by PKB Reactome R-HSA-165181
    Membrane Trafficking Reactome R-HSA-199991
    Generic Transcription Pathway Reactome R-HSA-212436
    Transcriptional Regulation by TP53 Reactome R-HSA-3700989
    Energy dependent regulation of mTOR by LKB1-AMPK Reactome R-HSA-380972
    TP53 Regulates Metabolic Genes Reactome R-HSA-5628897
    Vesicle-mediated transport Reactome R-HSA-5653656
    RNA Polymerase II Transcription Reactome R-HSA-73857
    Gene expression (Transcription) Reactome R-HSA-74160
    TBC/RABGAPs Reactome R-HSA-8854214
    Rab regulation of trafficking Reactome R-HSA-9007101
    Autophagy Reactome R-HSA-9612973
    4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression (WP3879) WikiPathways WP3879_r123400
    Thermogenesis (WP4321) WikiPathways WP4321_r123362
    Fragile X syndrome (WP4549) WikiPathways WP4549_r124287
    Thyroid hormones production and peripheral downstream signaling effects (WP4746) WikiPathways WP4746_r123317
    Glioblastoma signaling pathways (WP2261) WikiPathways WP2261_r123065
    Clear cell renal cell carcinoma pathways (WP4018) WikiPathways WP4018_r123404
    CAMKK2 pathway (WP4874) WikiPathways WP4874_r124683
    DYRK1A (WP5180) WikiPathways WP5180_r122423
    Focal adhesion: PI3K-Akt-mTOR-signaling pathway (WP3932) WikiPathways WP3932_r124527
    Wnt signaling pathway (WP363) WikiPathways WP363_r120695
    Insulin signaling (WP481) WikiPathways WP481_r120562
    BDNF-TrkB signaling (WP3676) WikiPathways WP3676_r116809
    AMP-activated protein kinase signaling (WP1403) WikiPathways WP1403_r123620
    Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway (WP4577) WikiPathways WP4577_r123500
    Head and neck squamous cell carcinoma (WP4674) WikiPathways WP4674_r123494
    Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids (WP5192) WikiPathways WP5192_r122557
    PI3K/AKT/mTOR - vitamin D3 signaling (WP4141) WikiPathways WP4141_r122432
    Nanoparticle triggered autophagic cell death (WP2509) WikiPathways WP2509_r101755
    Synaptic signaling pathways associated with autism spectrum disorder (WP4539) WikiPathways WP4539_r113659
    Malignant pleural mesothelioma (WP5087) WikiPathways WP5087_r122659
    PI3K-Akt signaling pathway (WP4172) WikiPathways WP4172_r122580
    T-cell activation SARS-CoV-2 (WP5098) WikiPathways WP5098_r119538
    Angiopoietin-like protein 8 regulatory pathway (WP3915) WikiPathways WP3915_r123920
    Target of rapamycin signaling (WP1471) WikiPathways WP1471_r123616
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_176216 1 miscRNA transcript variant 47 NC_000009 Reference
    NR_176217 1 miscRNA transcript variant 48 NC_000009 Reference
    NR_176214 1 miscRNA transcript variant 45 NC_000009 Reference
    NR_176218 1 miscRNA transcript variant 49 NC_000009 Reference
    NR_176215 1 miscRNA transcript variant 46 NC_000009 Reference
    XM_011518979 3 mRNA transcript variant X1 NC_000009 Reference
    NM_001406620 1 mRNA transcript variant 34 NC_000009 Reference
    NM_001406618 1 mRNA transcript variant 32 NC_000009 Reference
    NM_001406625 1 mRNA transcript variant 39 NC_000009 Reference
    NM_001406621 1 mRNA transcript variant 35 NC_000009 Reference
    NM_001406617 1 mRNA transcript variant 31 NC_000009 Reference
    NM_001406613 1 mRNA transcript variant 27 NC_000009 Reference
    NM_001406612 1 mRNA transcript variant 26 NC_000009 Reference
    NM_001406610 1 mRNA transcript variant 24 NC_000009 Reference
    NM_001406627 1 mRNA transcript variant 41 NC_000009 Reference
    NM_001406629 1 mRNA transcript variant 43 NC_000009 Reference
    NM_001406603 1 mRNA transcript variant 17 NC_000009 Reference
    NM_001406609 1 mRNA transcript variant 23 NC_000009 Reference
    NM_001406597 1 mRNA transcript variant 11 NC_000009 Reference
    NM_001406602 1 mRNA transcript variant 16 NC_000009 Reference
    NM_001406606 1 mRNA transcript variant 20 NC_000009 Reference
    NM_001406592 1 mRNA transcript variant 6 NC_000009 Reference
    NM_001406600 1 mRNA transcript variant 14 NC_000009 Reference
    NM_001406595 1 mRNA transcript variant 9 NC_000009 Reference
    NM_001406619 1 mRNA transcript variant 33 NC_000009 Reference
    NM_001406598 1 mRNA transcript variant 12 NC_000009 Reference
    NM_001406607 1 mRNA transcript variant 21 NC_000009 Reference
    NM_001406593 1 mRNA transcript variant 7 NC_000009 Reference
    NM_001406596 1 mRNA transcript variant 10 NC_000009 Reference
    NM_001406622 1 mRNA transcript variant 36 NC_000009 Reference
    NM_001362177 2 mRNA transcript variant 5 NC_000009 Reference
    NM_001406614 1 mRNA transcript variant 28 NC_000009 Reference
    NM_001406611 1 mRNA transcript variant 25 NC_000009 Reference
    NM_001162427 2 mRNA transcript variant 4 NC_000009 Reference
    NM_001406628 1 mRNA transcript variant 42 NC_000009 Reference
    NM_001406626 1 mRNA transcript variant 40 NC_000009 Reference
    NM_001406604 1 mRNA transcript variant 18 NC_000009 Reference
    NM_001406608 1 mRNA transcript variant 22 NC_000009 Reference
    NM_001162426 2 mRNA transcript variant 3 NC_000009 Reference
    NM_001406601 1 mRNA transcript variant 15 NC_000009 Reference
    NM_001406605 1 mRNA transcript variant 19 NC_000009 Reference
    NM_000368 5 mRNA transcript variant 1 NC_000009 Reference
    NM_001406630 1 mRNA transcript variant 44 NC_000009 Reference
    NM_001406624 1 mRNA transcript variant 38 NC_000009 Reference
    NM_001406616 1 mRNA transcript variant 30 NC_000009 Reference
    NM_001406623 1 mRNA transcript variant 37 NC_000009 Reference
    NM_001406615 1 mRNA transcript variant 29 NC_000009 Reference
    NM_001406599 1 mRNA transcript variant 13 NC_000009 Reference
    NM_001406594 1 mRNA transcript variant 8 NC_000009 Reference