BNIP3

BCL2 interacting protein 3
General Information
Name BCL2 interacting protein 3
Alias
  • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
  • BCL2/adenovirus E1B 19kDa interacting protein 3
  • BCL2/adenovirus E1B interacting protein 3
  • Hypoxia-Activated BNIP3 Overlapping Non-coding RNA
  • nineteen kD interacting protein-3
Synonyms Nip3 HABON NIP3
Gene_family BCL2 homology region 3 (BH3) only
organism Homo sapiens
entrez_id 664
location 10q26.3
transcript_count 1
exon_count 6
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]
      Stringdb BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer [...]
      nextProt Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    BNIP3 BioGRID FBXL4 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    BNIP3 BioGRID M GeneID BioGRID Proximity Label-MS
    BNIP3 BioGRID E GeneID BioGRID Proximity Label-MS
    BNIP3 BioGRID BMF GeneID BioGRID Negative Genetic
    BNIP3 BioGRID BCL2L12 GeneID BioGRID Negative Genetic
    BNIP3 BioGRID BBC3 GeneID BioGRID Negative Genetic
    BNIP3 BioGRID HRK GeneID BioGRID Negative Genetic
    BNIP3 BioGRID BNIP3L GeneID BioGRID Affinity Capture-MS; Negative Genetic; Two-hybrid
    BNIP3 BioGRID BIK GeneID BioGRID Negative Genetic; Two-hybrid
    BNIP3 BioGRID BID GeneID BioGRID Negative Genetic
    BNIP3 BioGRID BAX GeneID BioGRID Negative Genetic
    BNIP3 BioGRID ENPEP GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID RNF149 GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID PPTC7 GeneID BioGRID Affinity Capture-MS; Two-hybrid
    BNIP3 BioGRID PPP4R3B GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID TMEM30A GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID ABTB2 GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID TMEM11 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
    BNIP3 BioGRID RAC2 GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID AKAP1 GeneID BioGRID Proximity Label-MS
    BNIP3 BioGRID ATP5MK GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID MYO19 GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID HTRA2 GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID NR3C1 GeneID BioGRID Proximity Label-MS
    BNIP3 BioGRID MTCH2 GeneID BioGRID Proximity Label-MS
    BNIP3 BioGRID MTCH1 GeneID BioGRID Proximity Label-MS
    BNIP3 BioGRID MTX2 GeneID BioGRID Proximity Label-MS
    BNIP3 BioGRID KIF14 GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID HTR2B GeneID BioGRID Two-hybrid
    BNIP3 BioGRID GPR37 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID AGTR1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID BAG3 GeneID BioGRID Affinity Capture-Western
    BNIP3 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
    BNIP3 BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-Western
    BNIP3 BioGRID HPN GeneID BioGRID Two-hybrid
    BNIP3 BioGRID FFAR2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID GPR42 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID SLC31A2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID MS4A3 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID CD3E GeneID BioGRID Two-hybrid
    BNIP3 BioGRID BNIP3 GeneID BioGRID Reconstituted Complex; Two-hybrid
    BNIP3 BioGRID BNIP2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID FXYD6-FXYD2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID RNASEK GeneID BioGRID Two-hybrid
    BNIP3 BioGRID GPR152 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID SLC6A17 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID LDLRAD1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID TMEM205 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID FAM241B GeneID BioGRID Two-hybrid
    BNIP3 BioGRID ARL13B GeneID BioGRID Two-hybrid
    BNIP3 BioGRID FAM209A GeneID BioGRID Two-hybrid
    BNIP3 BioGRID ZDHHC15 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID TLCD4 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID TM4SF18 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID CMTM5 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID CREB3L1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID FATE1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID SMIM3 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID MFSD14B GeneID BioGRID Two-hybrid
    BNIP3 BioGRID JAGN1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID TMEM101 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID SPACA1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID TMEM106C GeneID BioGRID Two-hybrid
    BNIP3 BioGRID CLEC7A GeneID BioGRID Two-hybrid
    BNIP3 BioGRID TNMD GeneID BioGRID Two-hybrid
    BNIP3 BioGRID AMIGO1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID RPRM GeneID BioGRID Two-hybrid
    BNIP3 BioGRID SCN3B GeneID BioGRID Two-hybrid
    BNIP3 BioGRID ERGIC3 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID REEP2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID TMX2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID SEC22A GeneID BioGRID Two-hybrid
    BNIP3 BioGRID RNF24 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID EBP GeneID BioGRID Two-hybrid
    BNIP3 BioGRID SEC23A GeneID BioGRID Two-hybrid
    BNIP3 BioGRID SLC35B1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID EBAG9 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID CLDN9 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID MALL GeneID BioGRID Two-hybrid
    BNIP3 BioGRID TMPRSS2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID ELOVL4 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID PLP2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID KTN1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID IFNGR2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID HIF1A GeneID BioGRID Reconstituted Complex
    BNIP3 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
    BNIP3 BioGRID BCL2L2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID ATG8 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID LMNA GeneID BioGRID Two-hybrid
    BNIP3 BioGRID PRKN GeneID BioGRID Co-localization
    BNIP3 BioGRID PINK1 GeneID BioGRID Affinity Capture-Western
    BNIP3 BioGRID CREB3 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID OPA1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    BNIP3 BioGRID BCL2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    BNIP3 BioGRID MAP1LC3B GeneID BioGRID Affinity Capture-Western; Co-localization; Reconstituted Complex
    BNIP3 BioGRID TGM2 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID HIVEP1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID CLN8 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID RHEB GeneID BioGRID FRET; Two-hybrid
    BNIP3 BioGRID HDAC1 GeneID BioGRID Affinity Capture-Western
    BNIP3 Protein TMEM11 GeneID HPRD None
    BNIP3 Protein BNIP3L GeneID HPRD None
    BNIP3 Protein BNIP3 GeneID HPRD None
    BNIP3 Protein CD47 GeneID HPRD None
    BNIP3 Protein NCBP1 GeneID HPRD None
    BNIP3 Protein BCL2L1 GeneID HPRD None
    BNIP3 Protein BCL2 GeneID HPRD None
    BNIP3 BioGRID BCL2L1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    BNIP3 BioGRID NCBP1 GeneID BioGRID Two-hybrid
    BNIP3 BioGRID CD47 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    BNIP3 TNFRSF21 0 0 143 162 1 1
    BNIP3 AFP 0 0 50 171 1 1
    BNIP3 CASP3 0 0 602 648 1 2
    BNIP3 NQO1 0 0 211 244 1 1
    BNIP3 UQCC2 0 0 148 179 1 1
    BNIP3 PTGS2 0 0 195 212 1 1
    BNIP3 TGFBR3 0 0 55 220 1 1
    BNIP3 SMURF1 0 0 263 309 1 1
    BNIP3 HCRT 0 0 274 274 1 1
    BNIP3 TRIB3 0 0 232 237 1 1
    BNIP3 ATG4D 0 0 376 487 1 2
    BNIP3 EGLN1 0 0 520 550 1 1
    BNIP3 AGPAT9 0 0 53 156 1 1
    BNIP3 NLRP3 0 0 257 256 1 2
    BNIP3 OS9 0 0 324 323 1 1
    BNIP3 PLEKHM1 0 0 212 212 1 2
    BNIP3 ATG101 0 0 402 427 1 2
    BNIP3 CREBRF 0 0 119 182 1 1
    BNIP3 SETD1B 0 0 60 314 1 1
    BNIP3 CYBB 0 0 210 210 1 1
    BNIP3 VEGFC 0 0 133 168 1 1
    BNIP3 NIP7 0 0 245 593 1 1
    BNIP3 OMA1 0 0 266 266 1 1
    BNIP3 DIRAS3 0 0 210 222 1 2
    BNIP3 CDC42EP3 0 0 54 324 1 1
    BNIP3 TNFRSF10B 0 0 270 276 1 1
    BNIP3 CREG2 0 0 0 165 1 1
    BNIP3 ATG12 0 0 634 735 1 2
    BNIP3 CUL3 0 0 143 166 1 1
    BNIP3 CHUK 0 0 142 177 1 1
    BNIP3 ADM 0 0 268 313 1 1
    BNIP3 SFN 0 0 55 200 1 1
    BNIP3 CREG1 0 0 0 183 1 1
    BNIP3 CDKN2A 0 0 310 309 1 2
    BNIP3 CASP4 0 0 176 256 1 2
    BNIP3 GSK3B 0 0 181 232 1 2
    BNIP3 MTCH2 96 0 86 197 1 1
    BNIP3 ARRDC3 0 0 134 157 1 1
    BNIP3 HIGD1A 0 0 294 311 1 1
    BNIP3 CRYAB 0 0 124 166 1 1
    BNIP3 AHSG 0 0 0 151 1 1
    BNIP3 TXNRD2 0 0 107 153 1 1
    BNIP3 LTBR 0 0 182 181 1 1
    BNIP3 PHB2 0 0 310 351 1 1
    BNIP3 RIPK1 0 0 195 195 1 1
    BNIP3 HDAC1 270 0 697 769 1 2
    BNIP3 MT-CO2 0 0 184 194 1 1
    BNIP3 TBC1D7 0 0 96 163 1 2
    BNIP3 CEBPB 0 0 184 183 1 1
    BNIP3 TXNRD1 0 0 112 202 1 1
    BNIP3 ATG16L1 0 0 495 533 1 2
    BNIP3 ANGPTL4 0 0 283 444 1 1
    BNIP3 TMEM11 674 0 46 675 1 1
    BNIP3 TCEB1 0 0 329 329 1 1
    BNIP3 MSTN 0 0 331 345 1 1
    BNIP3 XAF1 0 0 155 154 1 1
    BNIP3 DEPTOR 0 0 244 243 1 1
    BNIP3 ROMO1 0 0 102 190 1 1
    BNIP3 FASLG 0 0 323 323 1 1
    BNIP3 FOS 0 0 204 204 1 1
    BNIP3 TWIST1 0 0 170 169 1 1
    BNIP3 APLF 0 0 125 191 1 1
    BNIP3 DUSP3 0 0 0 261 1 1
    BNIP3 EPAS1 0 0 327 511 1 2
    BNIP3 FOXO1 0 0 518 527 1 2
    BNIP3 KRAS 0 0 217 293 1 1
    BNIP3 SOD2 0 0 391 440 1 1
    BNIP3 CASP14 0 0 135 257 1 1
    BNIP3 DNM1 0 0 125 180 1 1
    BNIP3 E2F1 0 0 181 181 1 1
    BNIP3 TFE3 0 0 113 202 1 1
    BNIP3 HSPA5 0 0 294 310 1 2
    BNIP3 FTH1 0 0 103 200 1 1
    BNIP3 HAX1 0 0 397 396 1 2
    BNIP3 MLST8 0 0 261 261 1 2
    BNIP3 PEA15 0 0 67 158 1 1
    BNIP3 MAPK11 0 0 97 159 1 1
    BNIP3 PEX3 0 0 181 181 1 2
    BNIP3 DUSP1 0 0 193 193 1 1
    BNIP3 PMAIP1 0 0 601 601 1 1
    BNIP3 TLR2 0 0 134 154 1 1
    BNIP3 LRRK2 0 0 181 182 1 2
    BNIP3 TOLLIP 0 0 150 186 1 1
    BNIP3 MLH1 0 0 216 216 1 1
    BNIP3 MET 0 0 193 193 1 1
    BNIP3 PHB 0 0 174 173 1 1
    BNIP3 BECN1 0 0 767 892 1 2
    BNIP3 THBS1 0 0 194 194 1 1
    BNIP3 NAPA 0 0 411 459 1 1
    BNIP3 GYS1 0 0 215 246 1 1
    BNIP3 ALG3 192 0 0 192 1 1
    BNIP3 COX4I2 0 0 459 464 1 1
    BNIP3 EIF4EBP2 0 0 0 164 1 1
    BNIP3 RHOBTB3 0 0 0 241 1 1
    BNIP3 DAD1 0 0 649 649 1 1
    BNIP3 PGF 0 0 142 289 1 1
    BNIP3 NOD1 0 0 183 200 1 1
    BNIP3 LPIN1 0 0 171 189 1 2
    BNIP3 SEC62 0 0 175 210 1 1
    BNIP3 YIPF1 0 0 325 325 1 1
    BNIP3 NLRP14 0 0 192 192 1 1
    BNIP3 MT-ND1 0 0 165 179 1 1
    BNIP3 CALCOCO2 0 0 561 561 1 2
    BNIP3 ATG5 0 0 683 789 1 2
    BNIP3 TIA1 0 0 74 173 1 1
    BNIP3 BCL2L14 0 0 314 329 1 1
    BNIP3 GBE1 0 0 134 277 1 1
    BNIP3 XBP1 0 0 274 294 1 2
    BNIP3 GYPA 0 0 251 251 1 1
    BNIP3 ATP4A 0 0 143 162 1 1
    BNIP3 PTPN1 0 0 134 153 1 1
    BNIP3 KTN1 353 0 0 353 1 1
    BNIP3 FUNDC2 0 0 82 332 1 1
    BNIP3 CTSB 0 0 294 329 1 2
    BNIP3 ACOX1 0 0 60 231 1 1
    BNIP3 MCL1 0 0 561 574 1 2
    BNIP3 SIRT1 0 0 501 554 1 2
    BNIP3 DDIT4L 0 0 167 167 1 1
    BNIP3 PTCHD2 0 0 165 165 1 1
    BNIP3 PDK4 0 0 241 276 1 1
    BNIP3 OPTN 0 0 556 563 1 2
    BNIP3 MAP3K5 0 0 215 215 1 1
    BNIP3 ESR1 0 0 247 246 1 1
    BNIP3 AFG3L2 0 0 90 165 1 1
    BNIP3 MSH2 0 0 103 161 1 1
    BNIP3 INPP5A 0 0 106 204 1 1
    BNIP3 HMGB1 0 0 226 225 1 2
    BNIP3 CTSK 0 0 81 193 1 1
    BNIP3 WLS 0 0 0 190 1 1
    BNIP3 SOD3 0 0 143 150 1 1
    BNIP3 CA12 0 0 166 165 1 1
    BNIP3 PRKCA 0 0 157 156 1 1
    BNIP3 RPS6KA1 0 0 161 178 1 1
    BNIP3 PTP4A1 0 0 72 274 1 1
    BNIP3 CFAP69 0 0 151 150 1 1
    BNIP3 ULK1 0 0 605 644 1 2
    BNIP3 GPX1 0 0 212 212 1 1
    BNIP3 MT-CO1 0 0 218 218 1 1
    BNIP3 TBP 0 0 138 158 1 1
    BNIP3 MT-CYB 0 0 166 172 1 1
    BNIP3 FN1 0 0 195 215 1 1
    BNIP3 AKT3 0 0 108 221 1 1
    BNIP3 DPYSL4 0 0 93 156 1 1
    BNIP3 RT14 0 0 147 165 1 1
    BNIP3 USP30 0 0 342 387 1 1
    BNIP3 ADI1 0 0 0 167 1 1
    BNIP3 ATG10 0 0 467 523 1 2
    BNIP3 S100A4 0 0 306 306 1 1
    BNIP3 EXOG 0 0 60 172 1 1
    BNIP3 HSPB1 0 0 150 186 1 1
    BNIP3 MAP1LC3B 270 0 894 944 1 2
    BNIP3 DFFB 0 0 171 171 1 1
    BNIP3 NDUFB8 0 0 170 188 1 1
    BNIP3 FAM50A 0 0 76 205 1 1
    BNIP3 C6orf174 0 0 103 159 1 1
    BNIP3 FBXO30 0 0 0 189 1 1
    BNIP3 CCAR1 0 0 66 166 1 1
    BNIP3 ATG7 0 0 681 757 1 2
    BNIP3 DMD 0 0 142 201 1 1
    BNIP3 EGLN2 0 0 456 482 1 1
    BNIP3 ACTG1 0 0 134 188 1 1
    BNIP3 TIMM8B 0 0 122 154 1 1
    BNIP3 GDF15 0 0 195 242 1 1
    BNIP3 IL10 0 0 181 181 1 1
    BNIP3 SNAI1 0 0 161 161 1 1
    BNIP3 DAPK2 0 0 405 413 1 2
    BNIP3 NAMPT 0 0 171 201 1 1
    BNIP3 PPARGC1B 0 0 202 281 1 1
    BNIP3 CTSD 0 0 324 323 1 2
    BNIP3 EIF3F 0 0 151 182 1 1
    BNIP3 IDH2 0 0 182 199 1 1
    BNIP3 TRIM63 0 0 563 589 1 1
    BNIP3 IGF2 0 0 194 194 1 1
    BNIP3 DAP 0 0 194 199 1 2
    BNIP3 ATM 0 0 294 310 1 1
    BNIP3 TOMM70A 0 0 218 249 1 1
    BNIP3 G6PD 0 0 167 167 1 1
    BNIP3 ARSJ 0 0 326 325 1 1
    BNIP3 ZNF609 0 0 0 188 1 1
    BNIP3 ANKDD1A 0 0 113 159 1 1
    BNIP3 TRIM54 0 0 140 191 1 1
    BNIP3 AMBRA1 0 0 561 577 1 2
    BNIP3 LDHA 0 0 559 636 1 1
    BNIP3 MAP3K3 0 0 90 231 1 1
    BNIP3 COX8A 0 0 180 179 1 1
    BNIP3 LEP 0 0 143 161 1 1
    BNIP3 RHOT2 0 0 155 168 1 1
    BNIP3 NFKBIA 0 0 195 195 1 1
    BNIP3 C12orf5 0 0 408 408 1 1
    BNIP3 ENSG00000258947 0 0 327 340 1 1
    BNIP3 TIMP3 0 0 167 167 1 1
    BNIP3 RFWD3 0 0 46 262 1 1
    BNIP3 MAPK14 0 0 150 221 1 1
    BNIP3 TNFRSF9 0 0 118 181 1 1
    BNIP3 SREBF1 0 0 212 230 1 2
    BNIP3 FAM134B 0 0 323 323 1 1
    BNIP3 E2F3 0 0 181 182 1 1
    BNIP3 BAG1 0 0 286 286 1 2
    BNIP3 TP53BP2 0 0 261 261 1 1
    BNIP3 CHFR 0 0 218 218 1 1
    BNIP3 SLC2A14 0 0 336 405 1 1
    BNIP3 GABARAP 0 800 951 992 1 2
    BNIP3 MAPK7 0 0 167 168 1 1
    BNIP3 VEGFA 0 0 518 537 1 1
    BNIP3 PTEN 0 0 457 513 1 2
    BNIP3 SGSM1 0 0 63 204 1 1
    BNIP3 NUDT1 0 0 103 334 1 1
    BNIP3 MYOD1 0 0 230 229 1 1
    BNIP3 RHBDL2 0 0 0 177 1 1
    BNIP3 CASP5 0 0 134 218 1 1
    BNIP3 DNM1L 0 0 667 702 1 2
    BNIP3 WIPI1 0 0 423 450 1 2
    BNIP3 KIAA0226 0 0 170 169 1 1
    BNIP3 PRKAA2 0 0 141 212 1 2
    BNIP3 KIF14 270 0 0 270 1 1
    BNIP3 POU5F1 0 0 209 209 1 1
    BNIP3 HRK 0 0 509 515 1 1
    BNIP3 FH 0 0 414 426 1 1
    BNIP3 TXN 0 0 217 221 1 1
    BNIP3 CANX 0 0 175 232 1 2
    BNIP3 ATG2A 0 0 218 238 1 2
    BNIP3 TIMM10B 0 0 150 169 1 1
    BNIP3 PDPK1 0 0 125 167 1 2
    BNIP3 CAT 0 0 394 442 1 1
    BNIP3 PECAM1 0 0 194 194 1 1
    BNIP3 WBP1L 0 0 367 367 1 1
    BNIP3 MAD2L2 0 0 94 285 1 1
    BNIP3 MRPL57 0 0 94 164 1 1
    BNIP3 GNB2L1 0 0 329 329 1 1
    BNIP3 DFFA 0 0 153 160 1 1
    BNIP3 TECPR1 0 0 136 195 1 2
    BNIP3 GPAM 0 0 103 201 1 1
    BNIP3 BAK1 0 0 373 393 1 2
    BNIP3 BCL2 732 800 465 970 1 2
    BNIP3 NR1D1 0 0 123 180 1 2
    BNIP3 RHEB 312 900 986 999 1 2
    BNIP3 DDIT4 0 0 600 622 1 1
    BNIP3 MDN1 0 0 0 214 1 1
    BNIP3 HPRT1 0 0 211 257 1 1
    BNIP3 BCL2L2 204 0 508 603 1 1
    BNIP3 PLAGL2 0 0 219 223 1 1
    BNIP3 NOS3 0 0 235 235 1 1
    BNIP3 ULK3 0 0 112 157 1 2
    BNIP3 ANKRD37 0 0 362 392 1 1
    BNIP3 PRKAA1 0 0 150 203 1 2
    BNIP3 ARHGEF7 0 0 54 217 1 1
    BNIP3 ALDOC 0 0 375 445 1 1
    BNIP3 PPP1R3B 0 0 44 190 1 1
    BNIP3 CCND1 0 0 330 330 1 1
    BNIP3 STBD1 0 0 208 208 1 2
    BNIP3 EIF4E 0 0 223 240 1 1
    BNIP3 CDK1 0 0 166 197 1 1
    BNIP3 AHR 0 0 462 462 1 1
    BNIP3 SERPINE1 0 0 282 282 1 1
    BNIP3 ZBTB32 0 0 95 190 1 1
    BNIP3 BAD 0 0 209 209 1 1
    BNIP3 RPS6KB1 0 0 459 503 1 2
    BNIP3 YWHAQ 0 0 387 386 1 1
    BNIP3 REM1 0 0 0 154 1 1
    BNIP3 IRS1 0 0 210 211 1 1
    BNIP3 SGK1 0 0 189 236 1 1
    BNIP3 HSPA9 0 0 213 243 1 1
    BNIP3 LOX 0 0 294 320 1 1
    BNIP3 SESN1 0 0 310 327 1 2
    BNIP3 IFT43 0 0 155 154 1 1
    BNIP3 USP19 0 0 141 169 1 1
    BNIP3 RETN 0 0 0 189 1 1
    BNIP3 PGAM1 0 0 234 288 1 1
    BNIP3 ATF3 0 0 232 231 1 1
    BNIP3 CCPG1 0 0 218 271 1 1
    BNIP3 PFKFB4 0 0 335 353 1 1
    BNIP3 ATOX1 0 0 119 372 1 1
    BNIP3 PKM 0 0 322 336 1 1
    BNIP3 GADD45A 0 0 323 323 1 1
    BNIP3 PLOD2 0 0 230 352 1 1
    BNIP3 MTFR1 0 0 123 163 1 1
    BNIP3 ARNTL 0 0 127 260 1 1
    BNIP3 MAPK1 0 0 150 165 1 2
    BNIP3 IGF1 0 0 362 373 1 1
    BNIP3 TNMD 274 0 0 274 1 1
    BNIP3 WDFY3 0 0 289 303 1 2
    BNIP3 UVRAG 0 0 469 502 1 2
    BNIP3 PPP2R2B 0 0 54 200 1 1
    BNIP3 GSTP1 0 0 161 161 1 1
    BNIP3 PPTC7 485 0 81 519 1 1
    BNIP3 ATG4B 0 0 519 572 1 2
    BNIP3 ATP12A 0 0 143 162 1 1
    BNIP3 PIK3C2G 0 0 123 173 1 1
    BNIP3 GCG 0 0 137 158 1 1
    BNIP3 PRDX2 0 0 145 175 1 1
    BNIP3 RPS6KA2 0 0 107 177 1 1
    BNIP3 CDK13 0 0 66 163 1 1
    BNIP3 TFRC 0 0 161 192 1 1
    BNIP3 CCND2 0 0 180 179 1 1
    BNIP3 BCL2A1 0 0 507 515 1 1
    BNIP3 TXNIP 0 0 231 247 1 1
    BNIP3 BMF 0 0 456 473 1 1
    BNIP3 FGF2 0 0 211 211 1 1
    BNIP3 RAB7A 0 0 367 453 1 2
    BNIP3 DRAM1 0 0 469 469 1 2
    BNIP3 RBM12B 0 0 155 186 1 1
    BNIP3 WIPI2 0 0 309 342 1 2
    BNIP3 HCRTR1 0 0 412 412 1 1
    BNIP3 FIS1 0 0 595 637 1 2
    BNIP3 NAIP 0 0 144 177 1 1
    BNIP3 BAG4 0 0 58 214 1 1
    BNIP3 VCL 0 0 157 157 1 1
    BNIP3 PPP1R15A 0 0 171 171 1 2
    BNIP3 ZFAND5 0 0 142 300 1 1
    BNIP3 MIOX 0 0 122 154 1 1
    BNIP3 LINS 0 0 73 226 1 1
    BNIP3 C22orf29 0 0 681 681 1 1
    BNIP3 TNF 0 0 373 378 1 1
    BNIP3 TANK 0 0 138 179 1 1
    BNIP3 NBR1 0 0 564 600 1 2
    BNIP3 KDM3A 0 0 261 290 1 1
    BNIP3 HTR2C 0 0 0 434 1 1
    BNIP3 CASP2 0 0 243 355 1 1
    BNIP3 UCP3 0 0 418 418 1 1
    BNIP3 ARNT2 0 0 108 201 1 1
    BNIP3 ECHDC2 0 0 0 156 1 1
    BNIP3 CD44 0 0 154 153 1 1
    BNIP3 BDNF 0 0 135 154 1 2
    BNIP3 ANKRD1 0 0 124 161 1 1
    BNIP3 ATF6 0 0 267 267 1 2
    BNIP3 IKBKB 0 0 218 240 1 1
    BNIP3 NLRC4 0 0 160 159 1 2
    BNIP3 TPT1 0 0 536 536 1 1
    BNIP3 PPFIA4 0 0 103 179 1 1
    BNIP3 CDK8 0 0 45 254 1 1
    BNIP3 CDH6 0 0 693 693 1 1
    BNIP3 XIAP 0 0 323 323 1 1
    BNIP3 PARL 0 0 466 503 1 1
    BNIP3 PPP2R4 0 0 154 153 1 1
    BNIP3 VMP1 0 0 284 302 1 2
    BNIP3 TMEM74 0 0 294 307 1 2
    BNIP3 E2F4 0 0 175 187 1 1
    BNIP3 NOX4 0 0 218 261 1 1
    BNIP3 SDHD 0 0 218 235 1 1
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    BNIP3 SP1 0 0 156 155 1 1
    BNIP3 RAB5A 0 0 181 199 1 2
    BNIP3 IL1B 0 0 318 317 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0051020 Molecular Function GTPase binding enables IPI
    GO:0140506 Molecular Function endoplasmic reticulum-autophagosome adaptor activity enables IDA
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0140580 Molecular Function mitochondrion autophagosome adaptor activity enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0042803 Molecular Function protein homodimerization activity enables IDA
    GO:0048102 Biological Process autophagic cell death involved_in IEA
    GO:0000422 Biological Process autophagy of mitochondrion involved_in NAS
    GO:0050873 Biological Process brown fat cell differentiation involved_in IEA
    GO:0010659 Biological Process cardiac muscle cell apoptotic process involved_in IEA
    GO:0071279 Biological Process cellular response to cobalt ion involved_in IMP
    GO:0070301 Biological Process cellular response to hydrogen peroxide involved_in IEA
    GO:0071456 Biological Process cellular response to hypoxia acts_upstream_of_or_within IGI
    GO:0071456 Biological Process cellular response to hypoxia involved_in IMP
    GO:0071260 Biological Process cellular response to mechanical stimulus involved_in IEP
    GO:0021987 Biological Process cerebral cortex development involved_in IEA
    GO:0051607 Biological Process defense response to virus involved_in IDA
    GO:0140507 Biological Process granzyme-mediated programmed cell death signaling pathway involved_in IDA
    GO:1990144 Biological Process intrinsic apoptotic signaling pathway in response to hypoxia involved_in IMP
    GO:0043653 Biological Process mitochondrial fragmentation involved in apoptotic process involved_in IDA
    GO:0097345 Biological Process mitochondrial outer membrane permeabilization involved_in IBA
    GO:0097345 Biological Process mitochondrial outer membrane permeabilization involved_in IDA
    GO:0035694 Biological Process mitochondrial protein catabolic process involved_in IMP
    GO:0000423 Biological Process mitophagy involved_in IMP
    GO:0043066 Biological Process negative regulation of apoptotic process involved_in TAS
    GO:0045837 Biological Process negative regulation of membrane potential involved_in IDA
    GO:0010637 Biological Process negative regulation of mitochondrial fusion involved_in IDA
    GO:1902109 Biological Process negative regulation of mitochondrial membrane permeability involved in apoptotic process involved_in IEA
    GO:0010917 Biological Process negative regulation of mitochondrial membrane potential involved_in IEA
    GO:0043069 Biological Process negative regulation of programmed cell death acts_upstream_of_or_within IGI
    GO:0051402 Biological Process neuron apoptotic process involved_in ISS
    GO:0048709 Biological Process oligodendrocyte differentiation involved_in IEA
    GO:0043065 Biological Process positive regulation of apoptotic process involved_in IDA
    GO:0010508 Biological Process positive regulation of autophagy involved_in TAS
    GO:1903599 Biological Process positive regulation of autophagy of mitochondrion involved_in IEA
    GO:0010666 Biological Process positive regulation of cardiac muscle cell apoptotic process involved_in IEA
    GO:0016239 Biological Process positive regulation of macroautophagy acts_upstream_of_or_within IGI
    GO:0051561 Biological Process positive regulation of mitochondrial calcium ion concentration involved_in IEA
    GO:0090141 Biological Process positive regulation of mitochondrial fission involved_in IDA
    GO:0043068 Biological Process positive regulation of programmed cell death involved_in IBA
    GO:0043068 Biological Process positive regulation of programmed cell death involved_in IDA
    GO:0043243 Biological Process positive regulation of protein-containing complex disassembly involved_in IDA
    GO:0090200 Biological Process positive regulation of release of cytochrome c from mitochondria involved_in IDA
    GO:0072593 Biological Process reactive oxygen species metabolic process involved_in IDA
    GO:0046902 Biological Process regulation of mitochondrial membrane permeability involved_in IDA
    GO:0048678 Biological Process response to axon injury involved_in IEA
    GO:0009617 Biological Process response to bacterium involved_in IEA
    GO:0055093 Biological Process response to hyperoxia involved_in IEA
    GO:0001666 Biological Process response to hypoxia involved_in ISS
    GO:0090649 Biological Process response to oxygen-glucose deprivation involved_in IEA
    GO:0061709 Biological Process reticulophagy involved_in IMP
    GO:0005737 Cellular Component cytoplasm located_in ISS
    GO:0030425 Cellular Component dendrite located_in ISS
    GO:0005783 Cellular Component endoplasmic reticulum is_active_in IBA
    GO:0005783 Cellular Component endoplasmic reticulum located_in NAS
    GO:0005789 Cellular Component endoplasmic reticulum membrane is_active_in IDA
    GO:0031966 Cellular Component mitochondrial membrane located_in IDA
    GO:0031966 Cellular Component mitochondrial membrane located_in IMP
    GO:0005741 Cellular Component mitochondrial outer membrane is_active_in IBA
    GO:0005741 Cellular Component mitochondrial outer membrane is_active_in IDA
    GO:0005741 Cellular Component mitochondrial outer membrane located_in IDA
    GO:0005739 Cellular Component mitochondrion located_in HTP
    GO:0005739 Cellular Component mitochondrion located_in IDA
    GO:0005739 Cellular Component mitochondrion located_in TAS
    GO:0005635 Cellular Component nuclear envelope is_active_in IBA
    GO:0005635 Cellular Component nuclear envelope located_in IDA
    GO:0005654 Cellular Component nucleoplasm located_in ISS
    GO:0005634 Cellular Component nucleus is_active_in IBA
    GO:0005634 Cellular Component nucleus located_in ISS
    GO:0014069 Cellular Component postsynaptic density located_in IEA
    Pathways
    Name DB ID
    Photodynamic therapy-induced HIF-1 survival signaling (WP3614) WikiPathways WP3614_r106542
    Apoptosis modulation and signaling (WP1772) WikiPathways WP1772_r120736
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_004052 4 mRNA None NC_000010 Reference