TP53INP2

tumor protein p53 inducible nuclear protein 2
General Information
Name tumor protein p53 inducible nuclear protein 2
Alias
  • tumor protein p53-inducible nuclear protein 2
  • diabetes and obesity-regulated
  • p53-inducible protein U
Synonyms FLJ21759 FLJ23500 DKFZp434B2411 DKFZp434O0827 dJ1181N3.1 PINH DOR C20orf110 PIG-U PIGU
Gene_family None
organism Homo sapiens
entrez_id 58476
location 20q11.22
transcript_count 4
exon_count 6
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]
      Stringdb Tumor protein p53-inducible nuclear protein 2; Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA
      nextProt Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    TP53INP2 BioGRID N GeneID BioGRID Protein-peptide
    TP53INP2 BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-Western; Protein-peptide
    TP53INP2 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western
    TP53INP2 BioGRID RACK1 GeneID BioGRID Affinity Capture-MS
    TP53INP2 BioGRID BECN2 GeneID BioGRID Two-hybrid
    TP53INP2 BioGRID GABARAPL2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TP53INP2 CPT1B 0 0 81 289 1 1
    TP53INP2 CALML4 0 0 67 160 1 1
    TP53INP2 PLEKHN1 0 0 90 153 1 1
    TP53INP2 ATG10 0 0 166 165 1 2
    TP53INP2 HNRNPA2B1 0 0 218 218 1 1
    TP53INP2 TMCO4 0 0 369 466 1 1
    TP53INP2 INHBC 0 0 170 191 1 1
    TP53INP2 LRTOMT 0 0 60 227 1 1
    TP53INP2 SCIN 0 0 106 167 1 1
    TP53INP2 SDCCAG8 0 0 203 217 1 1
    TP53INP2 FUT1 0 0 122 183 1 1
    TP53INP2 MAP1LC3B 0 0 454 539 1 2
    TP53INP2 MAP9 0 0 161 161 1 1
    TP53INP2 ULK1 0 0 169 199 1 2
    TP53INP2 API5 0 0 96 292 1 1
    TP53INP2 NCAM1 0 0 0 150 1 1
    TP53INP2 SKIL 0 0 134 173 1 1
    TP53INP2 RPL5 0 0 60 205 1 1
    TP53INP2 ENSG00000205457 0 0 390 390 1 1
    TP53INP2 BTG3 0 0 96 187 1 1
    TP53INP2 BEST2 0 0 150 173 1 1
    TP53INP2 PDRG1 0 0 150 173 1 1
    TP53INP2 SIRT1 0 0 300 300 1 2
    TP53INP2 NPAS3 0 0 113 206 1 1
    TP53INP2 PLAC9 0 0 233 232 1 1
    TP53INP2 LMNB1 0 0 142 202 1 1
    TP53INP2 CAMKK1 0 0 120 195 1 1
    TP53INP2 ATG4A 0 0 263 263 1 2
    TP53INP2 OPTN 0 0 135 157 1 2
    TP53INP2 TRAF6 0 0 649 649 1 2
    TP53INP2 EPB41L4A 0 0 151 150 1 1
    TP53INP2 MRPL39 0 0 134 276 1 1
    TP53INP2 ATG5 0 0 218 218 1 2
    TP53INP2 MDFIC 0 0 90 230 1 1
    TP53INP2 RNF32 0 0 233 309 1 1
    TP53INP2 ENTPD5 0 0 120 232 1 1
    TP53INP2 TBC1D5 0 0 244 310 1 2
    TP53INP2 MYBL2 0 0 67 250 1 1
    TP53INP2 BAHCC1 0 0 204 263 1 1
    TP53INP2 TANC2 0 0 163 291 1 1
    TP53INP2 ACSF3 0 0 154 153 1 1
    TP53INP2 ATOH8 0 0 126 199 1 1
    TP53INP2 RAP1GAP2 0 0 142 257 1 1
    TP53INP2 GPRASP1 0 0 161 213 1 1
    TP53INP2 GABARAP 0 800 599 918 1 2
    TP53INP2 GADD45GIP1 0 0 135 323 1 1
    TP53INP2 WIPI1 0 0 180 179 1 2
    TP53INP2 RPL19 0 0 74 174 1 1
    TP53INP2 C12orf5 0 0 123 161 1 1
    TP53INP2 BIRC3 0 0 48 193 1 1
    TP53INP2 TP53BP2 0 0 101 157 1 1
    TP53INP2 ENSG00000205457 0 0 390 390 1 1
    TP53INP2 RFWD3 0 0 135 322 1 1
    TP53INP2 POLE2 0 0 125 187 1 1
    TP53INP2 TCF23 0 0 194 194 1 1
    TP53INP2 OR2L13 0 0 211 392 1 1
    TP53INP2 RAP1GAP 0 0 77 174 1 1
    TP53INP2 RERG 0 0 123 235 1 1
    TP53INP2 C10orf11 0 0 151 189 1 1
    TP53INP2 KCNIP3 0 0 95 188 1 1
    TP53INP2 ENSG00000278848 0 0 390 390 1 1
    TP53INP2 OR2AK2 0 0 0 219 1 1
    TP53INP2 GABRB1 0 0 101 166 1 1
    TP53INP2 ATG7 0 0 441 441 1 2
    TP53INP2 GLIS1 0 0 111 175 1 1
    TP53INP2 TAF1L 0 0 57 201 1 1
    TP53INP2 STK32A 0 0 217 217 1 1
    TP53INP2 FBXO9 0 0 49 216 1 1
    TP53INP2 ATG16L2 0 0 171 171 1 2
    TP53INP2 PROSC 0 0 162 161 1 1
    TP53INP2 TP53TG3B 0 0 390 390 1 1
    TP53INP2 PCGF3 0 0 142 216 1 1
    TP53INP2 GABARAPL1 0 800 391 882 1 2
    TP53INP2 ARSE 0 0 91 289 1 1
    TP53INP2 PTPRO 0 0 233 237 1 1
    TP53INP2 C14orf119 0 0 285 345 1 1
    TP53INP2 ATG16L1 0 0 210 210 1 2
    TP53INP2 SLC43A2 0 0 134 155 1 1
    TP53INP2 COL5A3 0 0 95 168 1 1
    TP53INP2 PMFBP1 0 0 210 210 1 1
    TP53INP2 KLK11 0 0 67 176 1 1
    TP53INP2 CDKN1A 0 0 117 182 1 2
    TP53INP2 HIP1R 0 0 101 192 1 1
    TP53INP2 GUSB 0 0 61 160 1 1
    TP53INP2 TOM1L1 0 0 149 279 1 1
    TP53INP2 SIPA1L3 0 0 232 249 1 1
    TP53INP2 DPEP1 0 0 149 202 1 1
    TP53INP2 TSPYL2 0 0 123 302 1 1
    TP53INP2 MAPK15 0 0 122 183 1 2
    TP53INP2 OSR2 0 0 103 167 1 1
    TP53INP2 SQSTM1 0 0 193 193 1 2
    TP53INP2 CRYM 0 0 107 169 1 1
    TP53INP2 ATG12 0 0 213 213 1 2
    TP53INP2 TP53TG3D 0 0 390 390 1 1
    TP53INP2 PRMT2 0 0 0 373 1 1
    TP53INP2 STS 0 0 0 160 1 1
    TP53INP2 GTSE1 0 0 98 154 1 1
    TP53INP2 TSPAN9 0 0 183 212 1 1
    TP53INP2 PDE6G 0 0 115 202 1 1
    TP53INP2 SLC19A3 0 0 134 222 1 1
    TP53INP2 RPSA 0 0 66 165 1 1
    TP53INP2 DNAJA4 0 0 113 178 1 1
    TP53INP2 LMO7 0 0 95 156 1 1
    TP53INP2 PLEKHM1 0 0 127 187 1 2
    TP53INP2 A1CF 0 0 261 261 1 1
    TP53INP2 DEXI 0 0 155 186 1 1
    TP53INP2 NELFA 0 0 134 152 1 1
    TP53INP2 RPL7 0 0 103 197 1 1
    TP53INP2 RFC5 0 0 96 158 1 1
    TP53INP2 RPL37A 0 0 105 243 1 1
    TP53INP2 TMEM173 0 0 123 157 1 1
    TP53INP2 TAF1 0 0 57 201 1 1
    TP53INP2 KIAA0226L 0 0 166 192 1 1
    TP53INP2 ESYT3 0 0 139 181 1 1
    TP53INP2 IVNS1ABP 0 0 134 188 1 1
    TP53INP2 ULK2 0 0 120 162 1 2
    TP53INP2 ELAVL4 0 0 66 320 1 1
    TP53INP2 DNAJC10 0 0 0 252 1 1
    TP53INP2 CDKN2B 0 0 140 193 1 1
    TP53INP2 SPSB4 0 0 170 192 1 1
    TP53INP2 PRKCH 0 0 124 216 1 1
    TP53INP2 KRTAP5-5 0 0 339 339 1 1
    TP53INP2 MTBP 0 0 135 224 1 1
    TP53INP2 TMBIM1 0 0 162 238 1 1
    TP53INP2 BECN1 0 0 298 298 1 2
    TP53INP2 CADM4 0 0 113 179 1 1
    TP53INP2 OR2L3 0 0 0 151 1 1
    TP53INP2 ARHGEF5 0 0 129 217 1 1
    TP53INP2 TBC1D25 0 0 173 230 1 1
    TP53INP2 FAM101A 0 0 183 183 1 1
    TP53INP2 APOO 0 0 0 160 1 1
    TP53INP2 JAKMIP3 0 0 231 369 1 1
    TP53INP2 NUPR1L 0 0 681 681 1 1
    TP53INP2 JAKMIP2 0 0 218 238 1 1
    TP53INP2 TNIP2 0 0 96 152 1 1
    TP53INP2 ALX1 0 0 108 201 1 1
    TP53INP2 SFR1 0 0 193 293 1 1
    TP53INP2 PCID2 0 0 181 263 1 1
    TP53INP2 AQP4 0 0 44 241 1 1
    TP53INP2 APCDD1 0 0 0 295 1 1
    TP53INP2 RPL4 0 0 73 216 1 1
    TP53INP2 APLP1 0 0 81 154 1 1
    TP53INP2 CAPN2 0 0 107 171 1 2
    TP53INP2 RPL39 0 0 115 251 1 1
    TP53INP2 GAS7 0 0 90 184 1 1
    TP53INP2 TCERG1L 0 0 173 173 1 1
    TP53INP2 PKHD1L1 0 0 167 319 1 1
    TP53INP2 SYPL2 0 0 193 208 1 1
    TP53INP2 PINK1 0 0 95 159 1 2
    TP53INP2 GAS2 0 0 95 327 1 1
    TP53INP2 EYA2 0 0 0 307 1 1
    TP53INP2 SPHKAP 0 0 155 216 1 1
    TP53INP2 ANK3 0 0 81 150 1 1
    TP53INP2 OR2L2 0 0 0 151 1 1
    TP53INP2 PDXK 0 0 112 176 1 1
    TP53INP2 NMT2 0 0 0 202 1 1
    TP53INP2 MAFK 0 0 0 185 1 1
    TP53INP2 OR2L8 0 0 0 151 1 1
    TP53INP2 MAPKBP1 0 0 139 215 1 1
    TP53INP2 LARP4B 0 0 103 159 1 1
    TP53INP2 VTI1A 0 0 103 159 1 1
    TP53INP2 MAP1LC3B2 0 0 0 170 1 2
    TP53INP2 FYCO1 0 0 294 315 1 2
    TP53INP2 BHMT 0 0 67 321 1 1
    TP53INP2 APOM 0 0 105 160 1 1
    TP53INP2 SAMD5 0 0 166 257 1 1
    TP53INP2 GNAL 0 0 95 160 1 1
    TP53INP2 ARL15 0 0 143 235 1 1
    TP53INP2 NTRK2 0 0 457 489 1 1
    TP53INP2 POLD2 0 0 104 165 1 1
    TP53INP2 MAP6 0 0 130 235 1 1
    TP53INP2 RGMB 0 0 113 202 1 1
    TP53INP2 GABARAPL2 192 800 597 932 1 2
    TP53INP2 ATIC 0 0 87 153 1 2
    TP53INP2 SPATA5L1 0 0 213 267 1 1
    TP53INP2 BCL9L 0 0 0 174 1 1
    TP53INP2 SPSB1 0 0 49 186 1 1
    TP53INP2 SSBP4 0 0 235 260 1 1
    TP53INP2 ATG14 0 0 184 183 1 2
    TP53INP2 MT1M 0 0 134 159 1 1
    TP53INP2 VMP1 0 800 716 940 1 2
    TP53INP2 METTL1 0 0 48 178 1 1
    TP53INP2 DYNLRB1 0 0 233 232 1 1
    TP53INP2 RPL11 0 0 66 210 1 1
    TP53INP2 C20orf24 0 0 194 194 1 1
    TP53INP2 BCAS1 0 0 220 253 1 1
    TP53INP2 RPL12 0 0 126 260 1 1
    TP53INP2 SBF2 0 0 103 154 1 1
    TP53INP2 CDCA4 0 0 150 173 1 1
    TP53INP2 BNIP3L 0 0 213 213 1 2
    TP53INP2 NMT1 0 0 98 446 1 1
    TP53INP2 PGA3 0 0 242 241 1 1
    TP53INP2 ZFYVE1 0 0 190 210 1 2
    TP53INP2 ADCY4 0 0 92 167 1 1
    TP53INP2 CDK2 0 0 90 160 1 1
    TP53INP2 MAP1LC3A 486 0 202 634 1 2
    TP53INP2 GIMAP8 0 0 173 260 1 1
    TP53INP2 PTPRU 0 0 229 228 1 1
    TP53INP2 ARSH 0 0 0 181 1 1
    TP53INP2 TP53TG3 0 0 375 375 1 1
    TP53INP2 KBTBD2 0 0 321 321 1 1
    TP53INP2 TP53I11 0 0 395 538 1 1
    TP53INP2 SIN3B 0 0 107 172 1 1
    TP53INP2 CD177 0 0 0 211 1 1
    TP53INP2 DNAJB11 0 0 95 493 1 1
    TP53INP2 ATG3 0 0 234 234 1 2
    TP53INP2 THRA 0 0 71 181 1 1
    TP53INP2 AP5B1 0 0 314 313 1 1
    TP53INP2 BIRC6 0 0 74 207 1 1
    TP53INP2 EID2 0 0 184 189 1 1
    TP53INP2 ELAVL3 0 0 0 160 1 1
    TP53INP2 IZUMO1 0 0 134 188 1 1
    TP53INP2 TEN1-CDK3 0 0 89 215 1 1
    TP53INP2 TP53INP1 0 0 562 160 1 2
    TP53INP2 PIK3C3 0 0 217 217 1 2
    TP53INP2 NCOR1 0 0 140 228 1 1
    TP53INP2 TP53I13 0 0 349 400 1 1
    TP53INP2 STBD1 0 0 141 246 1 2
    TP53INP2 ZNF787 0 0 181 213 1 1
    TP53INP2 NTRK1 0 0 469 469 1 1
    TP53INP2 TOM1L2 0 0 0 159 1 1
    TP53INP2 MDM2 0 0 166 172 1 1
    TP53INP2 TP53 0 0 268 323 1 2
    TP53INP2 RMI1 0 0 82 240 1 1
    TP53INP2 MAP1A 0 0 108 157 1 1
    TP53INP2 PYROXD1 0 0 217 353 1 1
    TP53INP2 RPRM 0 0 96 162 1 1
    TP53INP2 RPL36 0 0 106 243 1 1
    TP53INP2 JUND 0 0 0 206 1 1
    TP53INP2 UNCX 0 0 228 244 1 1
    TP53INP2 ULK3 0 0 206 224 1 2
    TP53INP2 PRIMA1 0 0 127 167 1 1
    TP53INP2 RPS16 0 0 145 277 1 1
    TP53INP2 TECPR1 0 0 150 180 1 2
    TP53INP2 TP53I3 0 0 183 200 1 1
    TP53INP2 EML1 0 0 131 265 1 1
    TP53INP2 MYBL1 0 0 81 157 1 1
    TP53INP2 MSTO1 0 0 181 367 1 1
    TP53INP2 TP53RK 0 0 236 353 1 1
    TP53INP2 RAD54B 0 0 161 180 1 1
    TP53INP2 CD300C 0 0 334 334 1 1
    TP53INP2 PID1 0 0 122 209 1 1
    TP53INP2 BARD1 0 0 92 183 1 1
    TP53INP2 CDIP1 0 0 277 316 1 1
    TP53INP2 RASAL1 0 0 95 173 1 1
    TP53INP2 SLC19A1 0 0 74 448 1 1
    TP53INP2 ASB15 0 0 204 235 1 1
    TP53INP2 NBR1 0 0 138 172 1 2
    TP53INP2 TECPR2 0 0 202 286 1 2
    TP53INP2 TNK1 0 0 127 218 1 1
    TP53INP2 MANBAL 0 0 262 262 1 1
    TP53INP2 PTGFR 0 0 95 158 1 1
    TP53INP2 TP53TG5 0 0 274 435 1 1
    TP53INP2 HNF4G 0 0 95 151 1 1
    TP53INP2 RBM28 0 0 0 215 1 1
    TP53INP2 C8orf4 0 0 141 613 1 1
    TP53INP2 LRP11 0 0 156 239 1 1
    TP53INP2 CDK3 0 0 89 215 1 1
    TP53INP2 OR2L5 0 0 0 151 1 1
    TP53INP2 ITCH 0 0 154 153 1 1
    TP53INP2 C19orf26 0 0 374 374 1 1
    TP53INP2 RRS1 0 0 234 286 1 1
    TP53INP2 CCND2 0 0 75 172 1 1
    TP53INP2 GOT1L1 0 0 232 231 1 1
    TP53INP2 TFAP2A 0 0 150 168 1 1
    TP53INP2 NUPR1 0 0 256 256 1 1
    TP53INP2 SOS1 0 0 96 162 1 1
    TP53INP2 ATG4B 0 0 170 169 1 2
    TP53INP2 DRAM1 0 0 242 241 1 2
    TP53INP2 NOL3 0 0 202 202 1 1
    TP53INP2 PITX1 0 0 73 171 1 1
    TP53INP2 ARSD 0 0 0 181 1 1
    TP53INP2 WDFY3 0 0 195 195 1 2
    TP53INP2 CDC5L 0 0 75 491 1 1
    TP53INP2 LIPF 0 0 134 285 1 1
    TP53INP2 ICA1L 0 0 324 392 1 1
    TP53INP2 EIF2B5 0 0 106 183 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0043130 Molecular Function ubiquitin binding enables IEA
    GO:0000045 Biological Process autophagosome assembly involved_in IBA
    GO:0000045 Biological Process autophagosome assembly involved_in IDA
    GO:1903828 Biological Process negative regulation of protein localization involved_in IEA
    GO:0001649 Biological Process osteoblast differentiation involved_in IEA
    GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in IBA
    GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in IDA
    GO:0008104 Biological Process protein localization involved_in IEA
    GO:0001894 Biological Process tissue homeostasis involved_in IEA
    GO:0006511 Biological Process ubiquitin-dependent protein catabolic process involved_in IEA
    GO:0016605 Cellular Component PML body located_in IEA
    GO:0005776 Cellular Component autophagosome is_active_in IBA
    GO:0005776 Cellular Component autophagosome located_in IDA
    GO:0031410 Cellular Component cytoplasmic vesicle located_in IEA
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005634 Cellular Component nucleus is_active_in IBA
    GO:0005634 Cellular Component nucleus located_in IDA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_021202 3 mRNA transcript variant 1 NC_000020 Reference
    NM_001329429 2 mRNA transcript variant 2 NC_000020 Reference
    NM_001329430 2 mRNA transcript variant 3 NC_000020 Reference
    NM_001329431 2 mRNA transcript variant 4 NC_000020 Reference