EPG5

ectopic P-granules 5 autophagy tethering factor
General Information
Name ectopic P-granules 5 autophagy tethering factor
Alias
  • ectopic P granules protein 5 homolog
  • ectopic P-granules autophagy protein 5 homolog
Synonyms hEPG5 HEEW1 KIAA1632 VICIS
Gene_family None
organism Homo sapiens
entrez_id 57724
location 18q12.3-q21.1
transcript_count 21
exon_count 46
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a large coiled coil domain-containing protein that functions in autophagy during starvation conditions. Mutations in this gene cause Vici syndrome. [provided by RefSeq, Aug 2015]
      Stringdb Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo
      nextProt Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    EPG5 BioGRID H2BC8 GeneID BioGRID Cross-Linking-MS (XL-MS)
    EPG5 BioGRID ZDHHC15 GeneID BioGRID Affinity Capture-MS
    EPG5 BioGRID BTNL9 GeneID BioGRID Affinity Capture-MS
    EPG5 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
    EPG5 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    EPG5 BioGRID CREBBP GeneID BioGRID Two-hybrid
    EPG5 BioGRID MAP1LC3A GeneID BioGRID Affinity Capture-Western
    EPG5 BioGRID USP8 GeneID BioGRID Affinity Capture-Western; Co-localization
    EPG5 BioGRID APEX1 GeneID BioGRID Affinity Capture-RNA
    EPG5 BioGRID VIRMA GeneID BioGRID Affinity Capture-RNA
    EPG5 BioGRID AGR2 GeneID BioGRID Proximity Label-MS
    EPG5 BioGRID Psmb5 GeneID BioGRID Affinity Capture-MS
    EPG5 BioGRID TP53 GeneID BioGRID Synthetic Growth Defect
    EPG5 None ATF7IP GeneID HPRD None
    StringDB
    A B experiments database textmining combined score hadb nhadb
    EPG5 ROBO4 0 0 0 531 1 1
    EPG5 VPS11 0 0 108 201 1 2
    EPG5 NBR1 0 0 392 427 1 2
    EPG5 TECPR2 0 0 452 672 1 2
    EPG5 SNAP25 0 0 0 239 1 1
    EPG5 PPP1R7 0 0 48 307 1 1
    EPG5 IRGM 0 0 217 222 1 2
    EPG5 ARL8B 0 0 91 191 1 1
    EPG5 MTMR1 0 0 107 259 1 1
    EPG5 ZBED6 0 0 241 259 1 1
    EPG5 TMEM251 0 0 324 476 1 1
    EPG5 IFT20 0 0 95 342 1 1
    EPG5 WIPI2 0 0 342 589 1 2
    EPG5 GMNC 0 0 161 239 1 1
    EPG5 WDR45B 0 0 0 356 1 1
    EPG5 ZFYVE26 0 0 286 530 1 1
    EPG5 IFT140 0 0 0 208 1 1
    EPG5 PPP1R3C 0 0 0 248 1 1
    EPG5 MPHOSPH9 0 0 101 470 1 1
    EPG5 PPP1R36 0 0 314 437 1 1
    EPG5 ATG4B 0 0 205 499 1 2
    EPG5 VPS39 0 0 267 405 1 1
    EPG5 CEP83 0 0 54 218 1 1
    EPG5 TTN 0 0 123 183 1 1
    EPG5 DRAM1 0 0 283 357 1 2
    EPG5 RAB7A 0 0 600 844 1 2
    EPG5 RAB3GAP1 0 0 118 273 1 1
    EPG5 IFI35 0 0 84 176 1 1
    EPG5 CCPG1 0 0 92 150 1 1
    EPG5 RB1CC1 0 0 455 515 1 2
    EPG5 WDR45 0 0 517 707 1 2
    EPG5 FGD5 0 0 150 181 1 1
    EPG5 UVRAG 0 0 316 348 1 2
    EPG5 WDFY3 0 0 257 362 1 2
    EPG5 MTMR2 0 0 66 218 1 1
    EPG5 SPG11 0 0 260 321 1 1
    EPG5 MS4A4E 0 0 249 248 1 1
    EPG5 LAMP1 0 0 284 305 1 2
    EPG5 HTT 0 0 150 173 1 1
    EPG5 TNFAIP8 0 0 102 158 1 1
    EPG5 ATP2C1 0 0 74 480 1 1
    EPG5 FNBP4 0 0 213 213 1 1
    EPG5 MGA 0 0 0 179 1 1
    EPG5 RAB2A 0 0 277 391 1 1
    EPG5 SPTBN5 0 0 233 232 1 1
    EPG5 RAB10 0 0 108 246 1 1
    EPG5 WHAMM 0 0 171 370 1 1
    EPG5 SNAP23 0 0 66 259 1 1
    EPG5 LMNA 0 0 135 194 1 1
    EPG5 ULK3 0 0 161 218 1 2
    EPG5 CCDC178 0 0 261 261 1 1
    EPG5 PPP1R3B 0 0 0 245 1 1
    EPG5 SNX14 0 0 467 670 1 1
    EPG5 PRKAA1 0 0 135 222 1 2
    EPG5 TECPR1 0 0 209 321 1 2
    EPG5 VAMP8 0 0 465 744 1 2
    EPG5 B4GALT6 0 0 150 181 1 1
    EPG5 LOXHD1 0 0 156 155 1 1
    EPG5 CD300C 0 0 351 351 1 1
    EPG5 ATG2A 0 0 266 554 1 2
    EPG5 RAB9A 0 0 0 380 1 2
    EPG5 IMPDH2 0 0 0 163 1 1
    EPG5 DNAJC4 0 0 0 189 1 1
    EPG5 DNAJC17 0 0 0 189 1 1
    EPG5 OR1J2 0 0 194 194 1 1
    EPG5 C11orf73 0 0 243 359 1 1
    EPG5 KIAA1429 270 0 0 270 1 1
    EPG5 CHM 0 0 0 732 1 1
    EPG5 ATG2B 0 0 261 560 1 2
    EPG5 KDM5A 0 0 0 244 1 1
    EPG5 SH3BP4 0 0 156 378 1 1
    EPG5 CCZ1 0 0 216 269 1 1
    EPG5 BAG3 0 0 181 181 1 2
    EPG5 STX17 0 0 717 778 1 2
    EPG5 RAB11A 0 0 150 169 1 1
    EPG5 RAB5A 0 0 206 255 1 2
    EPG5 MYBPC3 0 0 217 217 1 1
    EPG5 CHML 0 0 113 752 1 1
    EPG5 TGFBRAP1 0 0 0 221 1 1
    EPG5 RAB7B 0 0 516 688 1 1
    EPG5 VAMP7 0 0 517 624 1 1
    EPG5 SBF2 0 0 113 174 1 1
    EPG5 TMEM41B 0 0 321 352 1 2
    EPG5 MAP1LC3A 270 0 193 523 1 2
    EPG5 BOLA2-SMG1P6 0 0 0 181 1 1
    EPG5 NKX1-2 0 0 205 231 1 1
    EPG5 ARL8A 0 0 72 174 1 1
    EPG5 RTTN 0 0 193 199 1 1
    EPG5 ENSG00000250232 0 0 505 700 1 1
    EPG5 MTOR 0 0 123 190 1 2
    EPG5 FAM162B 0 0 90 152 1 1
    EPG5 ATG4C 0 0 266 513 1 2
    EPG5 USP8 270 0 150 367 1 1
    EPG5 PLEK 0 0 142 160 1 1
    EPG5 ATG3 0 0 377 693 1 2
    EPG5 RNF112 0 0 135 154 1 1
    EPG5 BIRC6 0 0 84 210 1 1
    EPG5 ROBO2 0 0 0 670 1 1
    EPG5 PIK3C3 0 0 377 647 1 2
    EPG5 CHMP2B 0 0 171 350 1 2
    EPG5 NBPF15 0 0 222 222 1 1
    EPG5 ZBTB24 0 0 158 157 1 1
    EPG5 VPS37A 0 0 282 305 1 1
    EPG5 PINK1 0 0 167 205 1 2
    EPG5 RAB21 0 0 94 194 1 1
    EPG5 SDF4 0 0 0 410 1 1
    EPG5 PIKFYVE 0 0 112 188 1 1
    EPG5 TPCN2 0 0 135 451 1 1
    EPG5 SERPINI1 0 0 0 303 1 1
    EPG5 TLR9 0 0 253 253 1 1
    EPG5 TANC1 0 0 0 188 1 1
    EPG5 OR2A14 0 0 150 280 1 1
    EPG5 MAP1LC3B2 0 0 235 346 1 2
    EPG5 CCZ1B 0 0 213 267 1 1
    EPG5 PTGES2 0 0 95 287 1 1
    EPG5 DMXL1 0 0 181 242 1 1
    EPG5 ZBTB20 0 0 103 180 1 1
    EPG5 MTMR14 0 0 194 209 1 1
    EPG5 FYCO1 0 0 349 407 1 2
    EPG5 VPS13D 0 0 0 154 1 1
    EPG5 RAB33B 0 0 282 285 1 2
    EPG5 PIK3R4 0 0 379 630 1 2
    EPG5 WDR73 0 0 204 552 1 1
    EPG5 ALS2 0 0 162 195 1 1
    EPG5 GABARAPL2 0 0 400 563 1 2
    EPG5 ARL5B 0 0 233 312 1 1
    EPG5 GGCT 0 0 134 196 1 1
    EPG5 SMG1 0 0 0 181 1 1
    EPG5 GDI2 0 0 0 357 1 1
    EPG5 SPATA5 0 0 144 283 1 1
    EPG5 PPP1R3E 0 0 0 190 1 1
    EPG5 UHRF1BP1L 0 0 243 259 1 1
    EPG5 VMP1 0 0 558 798 1 2
    EPG5 RAB18 0 0 122 172 1 1
    EPG5 ATG14 0 0 558 768 1 2
    EPG5 LOH12CR1 0 0 287 286 1 1
    EPG5 DCAF10 0 0 0 151 1 1
    EPG5 YKT6 0 0 401 442 1 1
    EPG5 RC3H2 0 0 0 167 1 1
    EPG5 KIAA0226L 0 0 229 291 1 1
    EPG5 IPO7 0 0 96 204 1 1
    EPG5 ULK2 0 0 325 396 1 2
    EPG5 OR6C2 0 0 218 218 1 1
    EPG5 ZFYVE27 0 0 140 291 1 1
    EPG5 SNAP29 0 0 561 827 1 2
    EPG5 NAPA 0 0 155 177 1 1
    EPG5 BECN1 0 0 391 551 1 2
    EPG5 SNAPIN 0 0 139 230 1 1
    EPG5 MEF2BNB 0 0 417 496 1 1
    EPG5 GORASP2 0 0 147 332 1 1
    EPG5 MTCL1 0 0 187 187 1 1
    EPG5 C18orf8 0 0 170 421 1 1
    EPG5 EI24 0 0 654 840 1 2
    EPG5 CSRP2 0 0 134 261 1 1
    EPG5 CAMK4 0 0 0 208 1 1
    EPG5 TBC1D25 0 0 267 318 1 1
    EPG5 CCDC78 0 0 324 357 1 1
    EPG5 RILP 0 0 235 315 1 1
    EPG5 LRRC16A 0 0 145 330 1 1
    EPG5 IFT52 0 0 44 210 1 1
    EPG5 LAMP2 0 0 234 241 1 2
    EPG5 RMND1 0 0 195 195 1 1
    EPG5 TMEM41A 0 0 141 194 1 1
    EPG5 GABARAPL1 0 0 392 634 1 2
    EPG5 ROBO1 0 0 0 677 1 1
    EPG5 VPS16 0 0 244 305 1 1
    EPG5 IGDCC3 0 0 0 531 1 1
    EPG5 WDR91 0 0 358 527 1 1
    EPG5 PPP1R3D 0 0 0 303 1 1
    EPG5 RAB2B 0 0 97 240 1 1
    EPG5 ATG16L1 0 0 414 468 1 2
    EPG5 RAB1A 0 0 134 188 1 2
    EPG5 ZNF24 0 0 150 173 1 1
    EPG5 CELF4 0 0 133 152 1 1
    EPG5 CCNY 0 0 138 244 1 2
    EPG5 ATG9A 0 0 339 564 1 2
    EPG5 CCDC11 0 0 229 230 1 1
    EPG5 BZRAP1 0 0 171 222 1 1
    EPG5 SQSTM1 0 0 391 404 1 2
    EPG5 KLHL20 0 0 134 164 1 1
    EPG5 ZNF641 0 0 155 339 1 1
    EPG5 GDI1 0 0 0 357 1 1
    EPG5 UHRF1BP1 0 0 150 232 1 1
    EPG5 ATG12 0 0 369 468 1 2
    EPG5 NDUFB11 0 0 138 196 1 1
    EPG5 ENSG00000267140 0 0 181 181 1 1
    EPG5 ATG13 0 0 414 671 1 2
    EPG5 CLEC16A 0 0 181 198 1 2
    EPG5 VPS13C 0 0 157 229 1 1
    EPG5 ATG4D 0 0 234 492 1 2
    EPG5 ATG101 0 0 425 704 1 2
    EPG5 HSPB8 0 0 90 156 1 2
    EPG5 PLEKHM1 0 0 518 576 1 2
    EPG5 PPIC 0 0 47 200 1 1
    EPG5 TFEB 0 0 349 354 1 2
    EPG5 SOGA1 0 0 234 249 1 2
    EPG5 CTNS 0 0 134 445 1 1
    EPG5 GABARAP 0 0 391 634 1 2
    EPG5 KLHL40 0 0 181 193 1 1
    EPG5 INO80C 0 0 181 181 1 1
    EPG5 WIPI1 0 0 456 660 1 2
    EPG5 DNAJC12 0 0 52 198 1 1
    EPG5 KIAA0226 0 0 162 198 1 1
    EPG5 RC3H1 0 0 0 150 1 1
    EPG5 TBCK 0 0 135 179 1 1
    EPG5 ROBO3 0 0 0 670 1 1
    EPG5 AMBRA1 0 0 358 384 1 2
    EPG5 TEX101 0 0 163 252 1 1
    EPG5 DRAM2 0 0 166 176 1 2
    EPG5 CSNK2A2 0 0 0 181 1 1
    EPG5 FAM134A 0 0 207 207 1 1
    EPG5 SAMD12 0 0 181 181 1 1
    EPG5 VTI1B 0 0 175 193 1 2
    EPG5 EMC6 0 0 232 286 1 1
    EPG5 SNAP47 0 0 107 292 1 1
    EPG5 DNAJC30 0 0 0 189 1 1
    EPG5 VOPP1 0 0 54 199 1 1
    EPG5 RAB3GAP2 0 0 0 211 1 1
    EPG5 RAB9B 0 0 62 394 1 1
    EPG5 SLC44A1 0 0 112 188 1 1
    EPG5 DNM2 0 0 124 151 1 1
    EPG5 MAP1LC3C 0 0 268 374 1 2
    EPG5 ATG7 0 0 466 757 1 2
    EPG5 POLG 0 0 114 154 1 1
    EPG5 WDR7 0 0 134 227 1 1
    EPG5 AFF4 0 0 0 167 1 1
    EPG5 GTPBP1 0 0 0 188 1 1
    EPG5 TBC1D2 0 0 264 511 1 1
    EPG5 FMN1 0 0 0 181 1 1
    EPG5 ATG16L2 0 0 270 299 1 2
    EPG5 ATG10 0 0 294 402 1 2
    EPG5 VAMP3 0 0 47 150 1 1
    EPG5 TRAPPC11 0 0 188 221 1 1
    EPG5 CDC45 0 0 0 698 1 1
    EPG5 OXNAD1 0 0 90 296 1 1
    EPG5 WDFY4 0 0 0 175 1 1
    EPG5 RPRD1A 0 0 183 196 1 1
    EPG5 MAP1LC3B 0 0 252 361 1 2
    EPG5 VPS18 0 0 96 152 1 1
    EPG5 STX7 0 0 233 346 1 2
    EPG5 ULK1 0 0 374 439 1 2
    EPG5 VPS33A 0 0 360 386 1 1
    EPG5 KCTD2 0 0 180 231 1 1
    EPG5 USP24 0 0 0 163 1 1
    EPG5 SEC22B 0 0 94 156 1 1
    EPG5 CTIF 0 0 174 184 1 1
    EPG5 TBC1D15 0 0 232 237 1 1
    EPG5 MTM1 0 0 170 311 1 1
    EPG5 ATG4A 0 0 223 510 1 2
    EPG5 OPTN 0 0 242 241 1 2
    EPG5 ATG5 0 0 518 778 1 2
    EPG5 CALCOCO2 0 0 294 294 1 2
    EPG5 KLHL41 0 0 155 154 1 1
    EPG5 TBC1D5 0 0 204 258 1 2
    EPG5 MGME1 0 0 173 173 1 1
    EPG5 TANC2 0 0 181 366 1 1
    EPG5 AP4E1 0 0 55 151 1 1
    EPG5 PLEKHM2 0 0 261 290 1 2
    EPG5 ATP6AP2 0 0 123 432 1 1
    EPG5 MURC 0 0 156 155 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0097352 Biological Process autophagosome maturation involved_in IBA
    GO:1990786 Biological Process cellular response to dsDNA involved_in IMP
    GO:0051607 Biological Process defense response to virus involved_in IEA
    GO:0032456 Biological Process endocytic recycling involved_in IEA
    GO:0008333 Biological Process endosome to lysosome transport involved_in IMP
    GO:0010467 Biological Process gene expression involved_in IEA
    GO:0048877 Biological Process homeostasis of number of retina cells involved_in IEA
    GO:0048874 Biological Process host-mediated regulation of intestinal microbiota composition involved_in IEA
    GO:0070841 Biological Process inclusion body assembly involved_in IEA
    GO:0006954 Biological Process inflammatory response involved_in IEA
    GO:0140888 Biological Process interferon-mediated signaling pathway involved_in IEA
    GO:0098544 Biological Process maintenance of protein complex location involved_in IEA
    GO:0002385 Biological Process mucosal immune response involved_in IEA
    GO:0051402 Biological Process neuron apoptotic process involved_in IEA
    GO:0006862 Biological Process nucleotide transport involved_in IMP
    GO:0046530 Biological Process photoreceptor cell differentiation involved_in IEA
    GO:0140454 Biological Process protein aggregate center assembly involved_in IEA
    GO:0034342 Biological Process response to type III interferon involved_in IEA
    GO:0006986 Biological Process response to unfolded protein involved_in IEA
    GO:0034162 Biological Process toll-like receptor 9 signaling pathway acts_upstream_of_positive_effect IMP
    GO:0006511 Biological Process ubiquitin-dependent protein catabolic process involved_in IEA
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0005764 Cellular Component lysosome located_in IDA
    GO:0048471 Cellular Component perinuclear region of cytoplasm located_in IDA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XM_047437710 1 mRNA transcript variant X15 NC_000018 Reference
    XM_047437706 1 mRNA transcript variant X10 NC_000018 Reference
    NM_001410858 1 mRNA transcript variant 3 NC_000018 Reference
    XM_047437704 1 mRNA transcript variant X8 NC_000018 Reference
    XM_047437703 1 mRNA transcript variant X7 NC_000018 Reference
    XM_047437709 1 mRNA transcript variant X14 NC_000018 Reference
    XM_047437707 1 mRNA transcript variant X12 NC_000018 Reference
    XM_047437708 1 mRNA transcript variant X13 NC_000018 Reference
    XM_017025891 2 mRNA transcript variant X11 NC_000018 Reference
    XM_047437705 1 mRNA transcript variant X9 NC_000018 Reference
    NM_001410859 1 mRNA transcript variant 2 NC_000018 Reference
    XM_017025889 2 mRNA transcript variant X5 NC_000018 Reference
    NM_020964 3 mRNA transcript variant 1 NC_000018 Reference
    XM_011526122 2 mRNA transcript variant X3 NC_000018 Reference
    XM_047437701 1 mRNA transcript variant X6 NC_000018 Reference
    XM_047437699 1 mRNA transcript variant X2 NC_000018 Reference
    XM_047437700 1 mRNA transcript variant X4 NC_000018 Reference
    XM_047437698 1 mRNA transcript variant X1 NC_000018 Reference
    XM_047437711 1 mRNA transcript variant X16 NC_000018 Reference
    XM_047437712 1 mRNA transcript variant X17 NC_000018 Reference
    XM_047437713 1 mRNA transcript variant X18 NC_000018 Reference