ELAPOR1

endosome-lysosome associated apoptosis and autophagy regulator 1
General Information
Name endosome-lysosome associated apoptosis and autophagy regulator 1
Alias
  • endosome/lysosome-associated apoptosis and autophagy regulator 1
  • estrogen-induced gene 121 protein
  • maba1
Synonyms maba1 EIG121 KIAA1324
Gene_family None
organism Homo sapiens
entrez_id 57535
location 1p13.3
transcript_count 8
exon_count 24
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
      nextProt May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    ELAPOR1 BioGRID DCUN1D5 GeneID BioGRID Affinity Capture-MS
    ELAPOR1 BioGRID OSBPL3 GeneID BioGRID Affinity Capture-MS
    ELAPOR1 BioGRID TMEM131 GeneID BioGRID Affinity Capture-MS
    ELAPOR1 BioGRID TAF6L GeneID BioGRID Affinity Capture-MS
    ELAPOR1 BioGRID KLHL41 GeneID BioGRID Affinity Capture-MS
    ELAPOR1 BioGRID IQCB1 GeneID BioGRID Affinity Capture-MS
    ELAPOR1 BioGRID TAF1A GeneID BioGRID Affinity Capture-MS
    ELAPOR1 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    ELAPOR1 BioGRID INS GeneID BioGRID Affinity Capture-MS
    ELAPOR1 BioGRID TRIM63 GeneID BioGRID Two-hybrid
    ELAPOR1 BioGRID TRIM55 GeneID BioGRID Two-hybrid
    ELAPOR1 BioGRID ESR1 GeneID BioGRID Affinity Capture-MS
    ELAPOR1 BioGRID CIB1 GeneID BioGRID Two-hybrid
    ELAPOR1 BioGRID AGR2 GeneID BioGRID Proximity Label-MS
    ELAPOR1 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
    StringDB
    A B experiments database textmining combined score hadb nhadb
    KIAA1324 PELP1 0 0 134 325 2 1
    KIAA1324 PIK3CA 0 0 112 177 2 1
    KIAA1324 ATG4A 0 0 142 158 2 1
    KIAA1324 EI24 0 0 181 181 2 1
    KIAA1324 ATG9A 0 0 0 211 2 1
    KIAA1324 PSEN1 0 0 0 176 2 1
    KIAA1324 SQSTM1 0 0 0 174 2 1
    KIAA1324 ATG4C 0 0 134 151 2 1
    KIAA1324 ERBB2 0 0 125 237 2 1
    KIAA1324 NBR1 0 0 0 174 2 1
    KIAA1324 PTEN 0 0 123 182 2 1
    KIAA1324 CTSD 0 0 67 223 2 1
    KIAA1324 CTSB 0 0 62 259 2 1
    KIAA1324 LRRK2 0 0 0 194 2 1
    KIAA1324 HSPA5 0 0 445 454 2 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0003723 Molecular Function RNA binding enables HDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0000045 Biological Process autophagosome assembly involved_in IBA
    GO:0000045 Biological Process autophagosome assembly involved_in IMP
    GO:0009267 Biological Process cellular response to starvation involved_in IMP
    GO:2000786 Biological Process positive regulation of autophagosome assembly involved_in IMP
    GO:0044090 Biological Process positive regulation of vacuole organization involved_in IBA
    GO:0044090 Biological Process positive regulation of vacuole organization involved_in IMP
    GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IEA
    GO:0070062 Cellular Component extracellular exosome located_in HDA
    GO:0005770 Cellular Component late endosome colocalizes_with IBA
    GO:0005770 Cellular Component late endosome colocalizes_with IDA
    GO:0031902 Cellular Component late endosome membrane located_in IEA
    GO:0005765 Cellular Component lysosomal membrane located_in IEA
    GO:0005764 Cellular Component lysosome colocalizes_with IBA
    GO:0005764 Cellular Component lysosome colocalizes_with IDA
    GO:0005886 Cellular Component plasma membrane is_active_in IBA
    GO:0005886 Cellular Component plasma membrane located_in IDA
    GO:0005802 Cellular Component trans-Golgi network colocalizes_with IBA
    GO:0005802 Cellular Component trans-Golgi network colocalizes_with IDA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XM_011541825 3 mRNA transcript variant X1 NC_000001 Reference
    NM_020775 5 mRNA transcript variant 1 NC_000001 Reference
    XM_011541827 3 mRNA transcript variant X3 NC_000001 Reference
    NM_001267048 2 mRNA transcript variant 2 NC_000001 Reference
    NM_001284352 2 mRNA transcript variant 4 NC_000001 Reference
    XM_011541826 4 mRNA transcript variant X2 NC_000001 Reference
    XM_047426133 1 mRNA transcript variant X4 NC_000001 Reference
    NM_001284353 2 mRNA transcript variant 5 NC_000001 Reference