VPS11

VPS11 core subunit of CORVET and HOPS complexes
General Information
Name VPS11 core subunit of CORVET and HOPS complexes
Alias
  • vacuolar protein sorting-associated protein 11 homolog
  • RING finger protein 108
  • VPS11, CORVET/HOPS core subunit
  • vacuolar protein sorting 11 homolog
Synonyms RNF108 PEP5 END1 HLD12 HLD12; DYT32 hVPS11
Gene_family CORVET complex|HOPS complex|Ring finger proteins
organism Homo sapiens
entrez_id 55823
location 11q23.3
transcript_count 16
exon_count 17
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
      Stringdb Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...]
      nextProt Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    VPS11 BioGRID ORF3a GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Proximity Label-MS
    VPS11 BioGRID VPS39 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Two-hybrid
    VPS11 BioGRID PLEKHM1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    VPS11 BioGRID VPS18 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Cross-Linking-MS (XL-MS)
    VPS11 BioGRID ARRDC3 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID RAB11A GeneID BioGRID Affinity Capture-Western
    VPS11 BioGRID RAB7A GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    VPS11 BioGRID VPS41 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    VPS11 BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID HOOK3 GeneID BioGRID Co-fractionation
    VPS11 BioGRID HOOK1 GeneID BioGRID Co-fractionation
    VPS11 BioGRID VPS8 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
    VPS11 BioGRID VPS33A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
    VPS11 BioGRID VPS16 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    VPS11 BioGRID TGFBRAP1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    VPS11 BioGRID TTC9C GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID CYS1 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID TICAM1 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID TMEM266 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID CCDC92 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID ISOC2 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID RTL10 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID LRRC61 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID MID1IP1 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID SCYL3 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID PARVA GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID PARL GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID C3orf18 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID H2AP GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID ZNF263 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID RNF7 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID THRSP GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID S100A4 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID RLBP1 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID PSME1 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID GRSF1 GeneID BioGRID Two-hybrid
    VPS11 BioGRID CSTA GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID RAB9A GeneID BioGRID Proximity Label-MS
    VPS11 BioGRID RAB5A GeneID BioGRID Proximity Label-MS
    VPS11 BioGRID KRTAP10-8 GeneID BioGRID Two-hybrid
    VPS11 BioGRID Stxbp1 GeneID BioGRID Reconstituted Complex
    VPS11 BioGRID STX1A GeneID BioGRID Reconstituted Complex
    VPS11 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID UBE2L3 GeneID BioGRID Reconstituted Complex
    VPS11 BioGRID UBE2D2 GeneID BioGRID Reconstituted Complex
    VPS11 BioGRID ZUP1 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID SAMTOR GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID STX17 GeneID BioGRID Affinity Capture-Western
    VPS11 BioGRID Vps41 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID CAMSAP3 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID SCRIB GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID GTF2I GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID RNF166 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID RILP GeneID BioGRID Reconstituted Complex
    VPS11 BioGRID EZR GeneID BioGRID Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    VPS11 BioGRID RDX GeneID BioGRID Reconstituted Complex
    VPS11 BioGRID NTRK1 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID MSN GeneID BioGRID Reconstituted Complex
    VPS11 BioGRID NXF1 GeneID BioGRID Affinity Capture-RNA
    VPS11 BioGRID SHMT2 GeneID BioGRID Affinity Capture-RNA
    VPS11 BioGRID MOV10 GeneID BioGRID Affinity Capture-RNA
    VPS11 BioGRID KRTAP10-3 GeneID BioGRID Two-hybrid
    VPS11 BioGRID KDM1A GeneID BioGRID Two-hybrid
    VPS11 BioGRID EDNRA GeneID BioGRID Co-purification
    VPS11 BioGRID RNF181 GeneID BioGRID Two-hybrid
    VPS11 BioGRID MON1B GeneID BioGRID Two-hybrid
    VPS11 BioGRID NOTCH1 GeneID BioGRID Affinity Capture-MS
    VPS11 BioGRID RANBP17 GeneID BioGRID Co-fractionation
    VPS11 BioGRID WWP2 GeneID BioGRID Co-fractionation
    VPS11 BioGRID TRIM32 GeneID BioGRID Two-hybrid
    VPS11 BioGRID UVRAG GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    VPS11 BioGRID BMI1 GeneID BioGRID Two-hybrid
    VPS11 BioGRID LRSAM1 GeneID BioGRID Two-hybrid
    VPS11 BioGRID ECPAS GeneID BioGRID Co-fractionation; Two-hybrid
    VPS11 BioGRID Plk2 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    VPS11 BioGRID UBE2U GeneID BioGRID Two-hybrid
    VPS11 BioGRID TSG101 GeneID BioGRID Two-hybrid
    VPS11 BioGRID GGA3 GeneID BioGRID Biochemical Activity
    VPS11 Protein VPS33A GeneID HPRD None
    VPS11 Protein VPS16 GeneID HPRD None
    VPS11 Protein VPS45 GeneID HPRD None
    VPS11 Protein VPS18 GeneID HPRD None
    VPS11 Protein STX6 GeneID HPRD None
    VPS11 Protein LSM1 GeneID HPRD None
    VPS11 Protein STX8 GeneID HPRD None
    VPS11 Protein STX7 GeneID HPRD None
    VPS11 Protein BCAR1 GeneID HPRD None
    VPS11 Protein MARK3 GeneID HPRD None
    VPS11 Protein UVRAG GeneID HPRD None
    VPS11 Protein TFAP2B GeneID HPRD None
    VPS11 Protein STX1A GeneID HPRD None
    VPS11 BioGRID LSM1 GeneID BioGRID Two-hybrid
    VPS11 BioGRID STX7 GeneID BioGRID Affinity Capture-Western
    VPS11 BioGRID BCAR1 GeneID BioGRID Two-hybrid
    VPS11 BioGRID MARK3 GeneID BioGRID Two-hybrid
    VPS11 Protein STX8 GeneID BIND VPS11 interacts with STX8 (Syntaxin-8). This interaction was modeled on a demonstrated interaction between human VPS11 and STX8 (Syntaxin-8) from an unspecified species.
    VPS11 Protein STX7 GeneID BIND VPS11 interacts with STX7 (Syntaxin-7). This interaction was modeled on a demonstrated interaction between human VPS11 and STX7 (Syntaxin-7) from an unspecified species.
    VPS11 Protein STX1A GeneID BIND VPS11 interacts with STX1A (Syntaxin-1). This interaction was modeled on a demonstrated interaction between human VPS11 and STX1A (Syntaxin-1) from an unspecified species.
    VPS11 Protein STX6 GeneID BIND Vps11 interacts with Stx6 (Syntaxin-6). This interaction was modeled on a demonstrated interaction between human Vps11 and Stx6 (Syntaxin-6) from an unspecified species.
    VPS11 Protein VPS45 GeneID BIND VPS11 interacts with VPS45A (VPS45). This interaction was modeled on a demonstrated interaction between human VPS11 and rat VPS45.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    VPS11 ANP32B 0 0 95 185 1 1
    VPS11 ARF4 0 0 0 229 1 1
    VPS11 FBXL14 0 0 94 150 1 1
    VPS11 R3HDML 0 0 163 163 1 1
    VPS11 TRIM69 0 0 103 159 1 1
    VPS11 UBR2 0 0 150 247 1 1
    VPS11 MARCH10 0 0 134 173 1 1
    VPS11 NTRK2 0 0 397 410 1 1
    VPS11 GDI2 0 0 45 246 1 1
    VPS11 SCGB2A1 0 0 304 304 1 1
    VPS11 SPATA5 0 0 92 173 1 1
    VPS11 NLRC4 0 0 75 173 1 2
    VPS11 RNF133 0 0 148 217 1 1
    VPS11 RNF121 0 0 123 183 1 1
    VPS11 USO1 0 0 210 309 1 1
    VPS11 ARL15 0 0 0 208 1 1
    VPS11 ENSG00000260272 0 0 0 208 1 1
    VPS11 RASD2 0 0 0 213 1 1
    VPS11 UBE3A 0 0 81 160 1 1
    VPS11 MARCH6 0 0 139 178 1 1
    VPS11 ARL5A 0 0 0 402 1 1
    VPS11 VPS13D 0 0 120 601 1 1
    VPS11 AKT1 0 0 167 192 1 2
    VPS11 TRAPPC12 0 0 47 188 1 1
    VPS11 KLHDC9 0 0 0 156 1 1
    VPS11 RNF144A 0 0 108 201 1 1
    VPS11 WBP11 0 0 123 183 1 1
    VPS11 UBR4 0 0 66 181 1 1
    VPS11 AP2M1 0 0 62 246 1 1
    VPS11 PA1 0 0 123 283 1 1
    VPS11 VTI1A 0 0 150 927 1 1
    VPS11 DMXL1 0 0 0 232 1 1
    VPS11 NGF 0 0 193 210 1 1
    VPS11 WDR81 0 0 116 446 1 1
    VPS11 PLEKHF1 0 0 0 175 1 2
    VPS11 TRIM36 0 0 150 237 1 1
    VPS11 CCZ1B 0 0 474 741 1 1
    VPS11 NSMCE1 0 0 120 187 1 1
    VPS11 FBXL17 0 0 97 158 1 1
    VPS11 TMEM216 0 0 155 154 1 1
    VPS11 GOSR1 0 0 162 195 1 1
    VPS11 CLHC1 0 0 0 462 1 1
    VPS11 DPH5 0 0 45 166 1 1
    VPS11 SPRTN 0 0 103 300 1 1
    VPS11 ATP6V1A 0 0 113 284 1 1
    VPS11 RNF187 0 0 134 193 1 1
    VPS11 SYNGAP1 0 0 0 178 1 1
    VPS11 PTPN23 0 0 0 189 1 1
    VPS11 SMC4 0 0 107 217 1 1
    VPS11 RNF103 0 0 108 195 1 1
    VPS11 EDNRB 0 0 454 454 1 1
    VPS11 RTN4 0 0 416 416 1 1
    VPS11 RHOC 0 0 0 235 1 1
    VPS11 RNF7 0 0 134 222 1 1
    VPS11 PIKFYVE 0 0 210 569 1 1
    VPS11 RAB21 0 0 95 151 1 1
    VPS11 EHD1 0 0 73 217 1 1
    VPS11 DPH1 0 0 0 190 1 1
    VPS11 USP3 0 0 74 168 1 1
    VPS11 MAG 0 0 499 499 1 1
    VPS11 TTC1 0 0 75 242 1 1
    VPS11 WWP2 271 0 72 344 1 1
    VPS11 FAM126A 0 0 123 270 1 1
    VPS11 RNASE7 0 0 159 165 1 1
    VPS11 ATG3 0 0 243 401 1 2
    VPS11 DNAJB1 0 0 45 163 1 2
    VPS11 TRIM52 0 0 119 179 1 1
    VPS11 RABGEF1 0 0 325 547 1 1
    VPS11 BNIP1 0 0 173 189 1 2
    VPS11 DMXL2 0 0 0 232 1 1
    VPS11 HEXA 0 0 0 177 1 1
    VPS11 MVD 0 0 0 197 1 1
    VPS11 VHL 0 0 0 258 1 1
    VPS11 RAB25 0 0 0 390 1 2
    VPS11 EMG1 0 0 142 160 1 1
    VPS11 EED 0 0 0 181 1 1
    VPS11 ATG4C 0 0 194 283 1 2
    VPS11 MCM3 0 0 52 165 1 1
    VPS11 G2E3 0 0 108 152 1 1
    VPS11 GPN2 0 0 0 224 1 1
    VPS11 CDC42 0 0 91 259 1 1
    VPS11 EEA1 0 0 324 440 1 1
    VPS11 DENND5A 0 0 219 219 1 1
    VPS11 CUX2 0 0 0 161 1 1
    VPS11 ENSG00000250232 0 0 122 202 1 1
    VPS11 ENSG00000259316 0 0 0 178 1 1
    VPS11 TRAPPC3L 0 0 0 369 1 1
    VPS11 TRIP11 0 0 194 216 1 1
    VPS11 UBR1 0 0 139 208 1 1
    VPS11 BET1L 0 0 127 181 1 1
    VPS11 BOLA2-SMG1P6 0 0 0 249 1 1
    VPS11 VAMP7 0 0 246 583 1 1
    VPS11 SBF2 0 0 0 207 1 1
    VPS11 VPS45 213 0 518 927 1 1
    VPS11 PIK3C2A 0 0 0 167 1 2
    VPS11 GDA 0 0 166 165 1 1
    VPS11 RAB28 0 0 0 151 1 1
    VPS11 GORASP1 0 0 123 211 1 1
    VPS11 TSC2 0 0 95 159 1 2
    VPS11 TRAPPC1 0 0 216 574 1 1
    VPS11 TRRAP 0 0 0 188 1 1
    VPS11 HACE1 0 0 0 234 1 1
    VPS11 RAB7B 0 0 601 927 1 1
    VPS11 RBX1 0 0 117 282 1 1
    VPS11 LYST 0 0 124 525 1 1
    VPS11 STX17 270 0 695 934 1 2
    VPS11 DDX39B 0 0 0 341 1 1
    VPS11 RNF167 0 0 124 196 1 1
    VPS11 RAB11A 0 0 218 516 1 1
    VPS11 RAC2 0 0 0 219 1 1
    VPS11 RRAGA 0 0 0 158 1 2
    VPS11 MITF 0 0 108 239 1 1
    VPS11 STXBP2 0 0 0 635 1 1
    VPS11 CCZ1 0 0 496 752 1 1
    VPS11 RGS19 0 0 67 259 1 2
    VPS11 CLN8 0 0 93 156 1 1
    VPS11 RNF181 192 0 0 278 1 1
    VPS11 RHOH 0 0 0 219 1 1
    VPS11 TRAPPC6B 0 0 150 402 1 1
    VPS11 C11orf73 0 0 161 171 1 1
    VPS11 SEC13 0 0 74 270 1 1
    VPS11 CHMP4A 0 0 51 350 1 1
    VPS11 ATG2B 0 0 74 227 1 2
    VPS11 DNAJC27 0 0 0 261 1 1
    VPS11 UBB 0 0 0 158 1 1
    VPS11 TRIM42 0 0 134 195 1 1
    VPS11 ATG2A 0 0 167 259 1 2
    VPS11 FAF2 0 0 0 184 1 1
    VPS11 USP13 0 0 0 192 1 1
    VPS11 SRRM3 0 0 157 156 1 1
    VPS11 STXBP3 0 0 0 636 1 1
    VPS11 VPS41 871 900 756 999 1 1
    VPS11 EXOC1 0 0 142 235 1 1
    VPS11 DDX46 0 0 0 150 1 1
    VPS11 DCST1 0 0 144 203 1 1
    VPS11 RNASEL 0 0 47 164 1 1
    VPS11 RHEB 0 0 48 240 1 2
    VPS11 ITSN1 0 0 0 261 1 1
    VPS11 FEM1B 0 0 112 191 1 1
    VPS11 RAB14 0 0 69 232 1 1
    VPS11 RRAS2 0 0 0 213 1 1
    VPS11 TBC1D17 0 0 0 199 1 1
    VPS11 DNAJB2 0 0 75 234 1 1
    VPS11 AIMP1 0 0 120 186 1 1
    VPS11 RNF170 0 0 113 175 1 1
    VPS11 HEXB 0 0 0 177 1 1
    VPS11 ARL16 0 0 0 208 1 1
    VPS11 COPB1 0 0 0 150 1 1
    VPS11 FRS3 0 0 0 252 1 1
    VPS11 FAU 0 0 0 173 1 1
    VPS11 GID4 0 0 151 217 1 1
    VPS11 EPG5 0 0 108 201 1 2
    VPS11 ATR 0 0 0 167 1 1
    VPS11 AP1G2 0 0 0 201 1 1
    VPS11 UBE2I 0 0 81 157 1 1
    VPS11 RNF186 0 0 120 160 1 1
    VPS11 EDNRA 270 0 0 321 1 1
    VPS11 NTRK1 63 0 310 340 1 1
    VPS11 RRAD 0 0 0 213 1 1
    VPS11 UBL4A 0 0 86 201 1 1
    VPS11 PIK3C2B 0 0 54 182 1 1
    VPS11 GOLGA5 0 0 60 320 1 1
    VPS11 RERGL 0 0 0 213 1 1
    VPS11 REM1 0 0 0 213 1 1
    VPS11 EHD3 0 0 108 517 1 1
    VPS11 COG2 0 0 125 202 1 1
    VPS11 STX8 213 0 153 849 1 2
    VPS11 RPS6KB1 0 0 95 160 1 2
    VPS11 SLPI 0 0 157 156 1 1
    VPS11 PPP2CA 0 0 0 153 1 1
    VPS11 PRKDC 0 0 0 249 1 2
    VPS11 CHMP4B 0 0 0 344 1 2
    VPS11 UVRAG 270 0 458 757 1 2
    VPS11 AGK 0 0 0 160 1 1
    VPS11 WDFY3 0 0 143 361 1 2
    VPS11 DEFB4A 0 0 216 216 1 1
    VPS11 ITIH4 0 0 150 165 1 1
    VPS11 CSNK1G3 0 0 0 178 1 1
    VPS11 SNF8 0 0 157 184 1 1
    VPS11 WDR45 0 0 181 256 1 2
    VPS11 RAB39A 0 0 0 208 1 1
    VPS11 SPESP1 0 0 161 161 1 1
    VPS11 RNF41 0 0 128 220 1 1
    VPS11 CCDC132 0 0 134 346 1 1
    VPS11 RHEBL1 0 0 0 213 1 1
    VPS11 NEDD4L 0 0 210 266 1 1
    VPS11 ANKRD27 0 0 123 406 1 1
    VPS11 EXOC3L2 0 0 0 180 1 1
    VPS11 USP19 0 0 83 198 1 1
    VPS11 ITSN2 0 0 0 261 1 1
    VPS11 RAB7A 270 0 674 994 1 2
    VPS11 HECW1 0 0 91 165 1 1
    VPS11 SMC5 0 0 61 209 1 1
    VPS11 RUFY4 0 0 0 175 1 2
    VPS11 FNBP1L 0 0 47 150 1 1
    VPS11 RHOF 0 0 0 219 1 1
    VPS11 RNF166 128 0 122 221 1 1
    VPS11 CDK13 0 0 0 174 1 1
    VPS11 TFRC 0 0 167 178 1 1
    VPS11 PYCR2 0 0 112 203 1 1
    VPS11 PPP1R14B 0 0 113 168 1 1
    VPS11 PIK3C2G 0 0 66 189 1 1
    VPS11 RND3 0 0 0 219 1 1
    VPS11 ATG4B 0 0 134 233 1 2
    VPS11 AP2A2 0 0 0 226 1 1
    VPS11 TRIM74 0 0 166 171 1 1
    VPS11 SHF 0 0 90 307 1 1
    VPS11 EMB 0 0 418 418 1 1
    VPS11 RABL2B 0 0 0 390 1 1
    VPS11 RNF113A 0 0 125 155 1 1
    VPS11 SCAPER 0 0 260 310 1 1
    VPS11 SHPRH 0 0 71 178 1 1
    VPS11 ARIH2 0 0 141 200 1 1
    VPS11 WIPI2 0 0 181 291 1 2
    VPS11 PDCD6IP 0 0 0 176 1 1
    VPS11 WDR45B 0 0 123 233 1 1
    VPS11 CHMP2A 0 0 81 155 1 2
    VPS11 USP5 0 0 67 293 1 1
    VPS11 BDNF 0 0 272 272 1 2
    VPS11 VPS36 0 0 209 554 1 1
    VPS11 RNF185 0 0 102 235 1 1
    VPS11 MTMR1 0 0 0 163 1 1
    VPS11 HIPK3 0 0 75 168 1 1
    VPS11 VPS51 0 0 193 323 1 1
    VPS11 DNAJC6 0 0 57 174 1 1
    VPS11 RPAP1 0 0 161 161 1 1
    VPS11 VPS25 0 0 123 171 1 1
    VPS11 CDK12 0 0 0 174 1 1
    VPS11 SNAP25 0 0 95 188 1 1
    VPS11 UQCRC1 0 0 0 194 1 1
    VPS11 RNF25 0 0 103 159 1 1
    VPS11 SACM1L 0 0 0 165 1 1
    VPS11 TRAPPC6A 0 0 209 444 1 1
    VPS11 TNFAIP2 0 0 0 180 1 1
    VPS11 KIAA0368 270 0 419 560 1 1
    VPS11 AP4E1 0 0 0 201 1 1
    VPS11 PLEKHM2 0 0 270 315 1 2
    VPS11 CYTH1 0 0 180 215 1 1
    VPS11 ATG5 0 0 219 341 1 2
    VPS11 TRIML1 0 0 126 166 1 1
    VPS11 DYNC1H1 0 0 107 184 1 1
    VPS11 UBE2D2 270 0 108 462 1 1
    VPS11 LYN 0 0 0 155 1 1
    VPS11 EXOC3L1 0 0 0 180 1 1
    VPS11 PPP1CA 0 0 0 242 1 1
    VPS11 RAC1 0 0 0 219 1 1
    VPS11 RPL10L 0 0 0 272 1 1
    VPS11 TRAPPC5 0 0 193 511 1 1
    VPS11 BACE1 270 0 0 291 1 1
    VPS11 COG3 0 0 216 534 1 1
    VPS11 HECTD3 0 0 154 323 1 1
    VPS11 ENSG00000100926 0 0 0 357 1 1
    VPS11 PDZRN3 0 0 112 172 1 1
    VPS11 RAB22A 0 0 107 555 1 1
    VPS11 PJA2 0 0 107 175 1 1
    VPS11 CTSB 0 0 208 310 1 2
    VPS11 GEM 0 0 0 213 1 1
    VPS11 DYNLL2 0 0 96 285 1 1
    VPS11 RASL11B 0 0 0 213 1 1
    VPS11 SEC22B 0 0 181 282 1 1
    VPS11 RALA 0 0 49 219 1 1
    VPS11 PLEKHM3 0 0 0 188 1 1
    VPS11 RAG2 0 0 308 307 1 1
    VPS11 ULK1 0 0 183 221 1 2
    VPS11 STX7 270 0 310 851 1 2
    VPS11 RASL10A 0 0 0 213 1 1
    VPS11 UBE3B 0 0 96 231 1 1
    VPS11 THUMPD3 0 0 156 286 1 1
    VPS11 SUGT1 0 0 93 161 1 1
    VPS11 ISG15 0 0 62 177 1 1
    VPS11 WDFY4 0 0 0 285 1 1
    VPS11 VPS33B 0 900 557 995 1 1
    VPS11 TRNAU1AP 0 0 122 327 1 1
    VPS11 AGFG1 0 0 195 267 1 1
    VPS11 UBC 0 0 45 162 1 1
    VPS11 FUT1 0 0 0 188 1 1
    VPS11 MAP1LC3B 0 0 253 303 1 2
    VPS11 TMEM200A 0 0 145 195 1 1
    VPS11 ARL13B 0 0 0 208 1 1
    VPS11 GDE1 0 0 107 223 1 1
    VPS11 ATG10 0 0 160 172 1 2
    VPS11 PHLDB1 0 0 101 159 1 1
    VPS11 GRAMD1B 0 0 129 219 1 1
    VPS11 VAMP3 0 0 67 219 1 1
    VPS11 RT14 0 0 206 498 1 1
    VPS11 PMPCB 0 0 0 194 1 1
    VPS11 TSG101 108 0 123 309 1 2
    VPS11 ZSWIM5 0 0 150 237 1 1
    VPS11 ZFPL1 0 0 122 176 1 1
    VPS11 CDCP2 0 0 209 209 1 1
    VPS11 EXOC4 0 0 432 498 1 1
    VPS11 NICN1 0 0 298 317 1 1
    VPS11 MON2 0 0 0 202 1 1
    VPS11 MRAS 0 0 0 213 1 1
    VPS11 ATP6V0A1 0 0 108 280 1 1
    VPS11 TRAPPC2P1 0 0 150 277 1 1
    VPS11 RNF128 0 0 90 156 1 1
    VPS11 AREL1 0 0 124 299 1 1
    VPS11 SKAP2 0 0 162 176 1 1
    VPS11 ATG7 0 0 184 381 1 2
    VPS11 TRIM46 0 0 95 151 1 1
    VPS11 CCDC84 0 0 212 212 1 1
    VPS11 RNF220 0 0 112 152 1 1
    VPS11 DIRAS2 0 0 0 213 1 1
    VPS11 ENSG00000267261 0 0 0 717 1 1
    VPS11 UBE2O 0 0 85 200 1 1
    VPS11 TSEN34 0 0 45 310 1 1
    VPS11 ZNF263 189 0 0 189 1 1
    VPS11 VTI1B 0 0 503 881 1 2
    VPS11 EZR 270 0 72 293 1 1
    VPS11 NTF4 0 0 413 412 1 1
    VPS11 TRIM32 192 0 44 212 1 1
    VPS11 STX12 0 0 0 822 1 1
    VPS11 RNF26 0 0 211 220 1 1
    VPS11 PREB 0 0 54 211 1 1
    VPS11 CTSD 0 0 154 196 1 2
    VPS11 LRRC1 0 0 43 226 1 1
    VPS11 NGFR 0 0 329 329 1 1
    VPS11 WSB2 0 0 119 192 1 1
    VPS11 AP2A1 0 0 0 230 1 1
    VPS11 IFT46 0 0 95 187 1 1
    VPS11 TRIM67 0 0 113 168 1 1
    VPS11 RCHY1 0 0 143 264 1 1
    VPS11 NBEAL2 0 0 108 164 1 1
    VPS11 RFWD3 0 0 122 157 1 1
    VPS11 RASAL2 0 0 0 178 1 1
    VPS11 UBR3 0 0 181 315 1 1
    VPS11 GBA2 0 0 0 174 1 1
    VPS11 RHOT2 0 0 0 222 1 1
    VPS11 RNF157 0 0 123 184 1 1
    VPS11 AMBRA1 0 0 260 299 1 2
    VPS11 KIAA0226 0 0 210 259 1 1
    VPS11 SEC22A 0 0 0 159 1 1
    VPS11 MMP11 0 0 155 154 1 1
    VPS11 NAGPA 0 0 139 192 1 1
    VPS11 DET1 0 0 95 151 1 1
    VPS11 DNM1L 0 0 202 284 1 2
    VPS11 WIPI1 0 0 324 411 1 2
    VPS11 RRAGB 0 0 0 158 1 2
    VPS11 PI4KB 0 0 0 168 1 1
    VPS11 TRIM47 0 0 95 151 1 1
    VPS11 NTRK3 0 0 398 411 1 1
    VPS11 VPS26B 0 0 0 311 1 1
    VPS11 POU2F3 0 0 167 167 1 1
    VPS11 RAB5C 0 0 136 744 1 1
    VPS11 DSTYK 0 0 0 307 1 1
    VPS11 HECW2 0 0 91 187 1 1
    VPS11 BET1 0 0 183 193 1 1
    VPS11 LRR1 0 0 84 240 1 1
    VPS11 FEZ1 0 0 241 269 1 1
    VPS11 PVRL1 0 0 180 179 1 1
    VPS11 GABARAP 0 0 250 374 1 2
    VPS11 PLEKHM1 0 0 368 465 1 2
    VPS11 HSPB8 0 0 67 165 1 2
    VPS11 ATG101 0 0 142 199 1 2
    VPS11 CD99 0 0 158 183 1 1
    VPS11 ATG4D 0 0 120 308 1 2
    VPS11 MARCH9 0 0 104 160 1 1
    VPS11 RNF152 0 0 105 160 1 1
    VPS11 AP1G1 0 0 0 221 1 1
    VPS11 VPS29 0 0 324 511 1 1
    VPS11 GAPVD1 0 0 123 406 1 1
    VPS11 FGD6 0 0 0 175 1 1
    VPS11 RAB4B 0 0 0 286 1 1
    VPS11 FBXO27 0 0 123 184 1 1
    VPS11 MICALL1 0 0 86 329 1 1
    VPS11 ATP6V1B2 0 0 155 381 1 1
    VPS11 ATG12 0 0 202 231 1 2
    VPS11 COG7 0 0 164 270 1 1
    VPS11 EHD2 0 0 0 161 1 1
    VPS11 VPS13A 0 0 0 207 1 1
    VPS11 ZW10 0 0 186 381 1 1
    VPS11 GDI1 0 0 218 353 1 1
    VPS11 POLR3A 0 0 82 241 1 1
    VPS11 UBA2 0 0 59 151 1 1
    VPS11 STX16 0 0 81 475 1 1
    VPS11 DIRAS3 0 0 0 213 1 2
    VPS11 RNF151 0 0 166 206 1 1
    VPS11 SYS1 0 0 556 583 1 1
    VPS11 AAK1 0 0 171 206 1 1
    VPS11 GGA3 270 0 63 306 1 1
    VPS11 RAB20 0 0 0 518 1 1
    VPS11 EDA2R 0 0 73 174 1 1
    VPS11 DNAJC24 0 0 42 160 1 1
    VPS11 HIP1R 0 0 0 214 1 1
    VPS11 CDKN2A 0 0 124 157 1 2
    VPS11 CUL3 0 0 70 218 1 1
    VPS11 UNC119 0 0 217 234 1 1
    VPS11 FBXO17 0 0 112 173 1 1
    VPS11 ARFGAP1 0 0 70 159 1 1
    VPS11 ATP6V1C1 0 0 161 223 1 1
    VPS11 NTF3 0 0 398 398 1 1
    VPS11 RIN1 0 0 89 215 1 1
    VPS11 DLAT 0 0 115 156 1 1
    VPS11 TAF9B 0 0 108 199 1 1
    VPS11 ATG16L1 0 0 213 223 1 2
    VPS11 PIK3CD 0 0 0 167 1 1
    VPS11 RAB2B 0 0 0 334 1 1
    VPS11 PI4KA 0 0 0 168 1 1
    VPS11 TMEM106B 0 0 144 183 1 1
    VPS11 SCRIB 211 0 0 297 1 1
    VPS11 WDR91 0 0 143 233 1 1
    VPS11 RAB42 0 0 0 208 1 1
    VPS11 RNF150 0 0 122 218 1 1
    VPS11 SLC35D3 0 0 182 196 1 1
    VPS11 RHOD 0 0 0 219 1 1
    VPS11 MON1A 0 0 465 874 1 1
    VPS11 ENSG00000263620 0 0 0 195 1 1
    VPS11 ZNF598 0 0 210 309 1 1
    VPS11 TBC1D2B 0 0 45 161 1 1
    VPS11 RPL10 0 0 97 314 1 1
    VPS11 FAF1 0 0 0 222 1 1
    VPS11 TRAPPC2 0 0 150 277 1 1
    VPS11 RAB11B 0 0 0 413 1 1
    VPS11 RRAGC 0 0 95 212 1 1
    VPS11 ZNRF2 0 0 120 160 1 1
    VPS11 RNF34 0 0 102 158 1 1
    VPS11 MLST8 0 0 150 181 1 2
    VPS11 RABAC1 0 0 124 178 1 1
    VPS11 TBC1D25 0 0 77 229 1 1
    VPS11 ANKIB1 0 0 124 216 1 1
    VPS11 RNF13 0 0 113 189 1 1
    VPS11 LNX2 0 0 100 162 1 1
    VPS11 TFE3 0 0 209 292 1 1
    VPS11 DNM1 0 0 74 169 1 1
    VPS11 NRAS 0 0 0 213 1 1
    VPS11 RNF122 0 0 108 201 1 1
    VPS11 NANOS2 0 0 625 625 1 1
    VPS11 DTX2 0 0 95 151 1 1
    VPS11 RND2 0 0 0 219 1 1
    VPS11 DNAJC13 0 0 140 447 1 1
    VPS11 UEVLD 0 0 52 188 1 1
    VPS11 KRAS 0 0 0 213 1 1
    VPS11 RAB39B 0 0 0 208 1 2
    VPS11 ENSG00000280433 0 0 0 328 1 1
    VPS11 DTNBP1 0 0 74 395 1 1
    VPS11 RASL11A 0 0 0 213 1 1
    VPS11 SNX4 0 0 144 196 1 1
    VPS11 VAMP5 0 0 0 195 1 1
    VPS11 ARL4C 0 0 0 229 1 1
    VPS11 ARF6 0 0 0 238 1 1
    VPS11 STXBP1 0 0 67 657 1 1
    VPS11 NAPA 0 0 230 519 1 1
    VPS11 TBC1D21 0 0 0 199 1 1
    VPS11 RNF130 0 0 94 169 1 1
    VPS11 BECN1 0 0 380 566 1 2
    VPS11 STX10 0 0 0 791 1 1
    VPS11 CCDC22 0 0 91 249 1 1
    VPS11 RNF208 0 0 155 154 1 1
    VPS11 PIK3CB 0 0 0 167 1 1
    VPS11 HPS4 0 0 120 213 1 1
    VPS11 USMG5 0 0 109 168 1 1
    VPS11 CNP 0 0 0 151 1 1
    VPS11 CAND2 0 0 0 167 1 1
    VPS11 USP20 0 0 82 198 1 1
    VPS11 REM2 0 0 0 213 1 1
    VPS11 SYNRG 0 0 0 213 1 1
    VPS11 RNF141 0 0 142 201 1 1
    VPS11 RRAGD 0 0 57 179 1 1
    VPS11 RASL10B 0 0 0 213 1 1
    VPS11 RNF20 0 0 117 220 1 1
    VPS11 VHLL 0 0 0 258 1 1
    VPS11 ATP6V0A4 0 0 112 283 1 1
    VPS11 SFXN5 0 0 157 209 1 1
    VPS11 RHOBTB3 0 0 0 219 1 1
    VPS11 TRIM60 0 0 141 180 1 1
    VPS11 GAPDH 0 0 218 245 1 2
    VPS11 RIT2 0 0 0 213 1 1
    VPS11 ATG14 0 0 251 289 1 2
    VPS11 FGFR2 0 0 425 424 1 1
    VPS11 RNF6 0 0 91 166 1 1
    VPS11 ENSG00000258466 0 0 0 771 1 1
    VPS11 TMEM106C 0 0 54 220 1 1
    VPS11 RAP1A 0 0 0 222 1 1
    VPS11 GABARAPL2 0 0 289 416 1 2
    VPS11 ARL5B 0 0 341 589 1 1
    VPS11 SMG1 0 0 0 254 1 1
    VPS11 USP27X 0 0 103 259 1 1
    VPS11 TSNARE1 0 0 0 729 1 1
    VPS11 FBXO42 0 0 0 156 1 1
    VPS11 LONRF2 0 0 124 174 1 1
    VPS11 ATP6V1C2 0 0 127 172 1 1
    VPS11 PIK3R4 0 0 280 748 1 2
    VPS11 TOM1 0 0 210 325 1 1
    VPS11 FYCO1 0 0 103 229 1 2
    VPS11 CARM1 0 0 112 186 1 1
    VPS11 PELP1 0 0 0 183 1 2
    VPS11 C15orf27 478 0 0 478 1 1
    VPS11 ELMO3 0 0 61 183 1 1
    VPS11 PARP11 0 0 120 175 1 1
    VPS11 POLR2A 0 0 0 167 1 1
    VPS11 AP3B1 0 0 0 182 1 1
    VPS11 RHOJ 0 0 0 219 1 1
    VPS11 KCNE1 0 0 161 161 1 1
    VPS11 GRIA4 0 0 306 306 1 1
    VPS11 DYNC1LI1 0 0 82 224 1 1
    VPS11 PLEC 0 0 459 459 1 1
    VPS11 DPAGT1 0 0 211 279 1 1
    VPS11 BCAS4 0 0 0 206 1 1
    VPS11 SIAH1 0 0 90 226 1 1
    VPS11 PDP2 0 0 0 155 1 1
    VPS11 MAPKBP1 0 0 102 195 1 1
    VPS11 OSBPL1A 0 0 71 183 1 1
    VPS11 SC5D 0 0 124 156 1 1
    VPS11 SCAP 0 0 0 166 1 1
    VPS11 ARL3 0 0 0 208 1 1
    VPS11 FIG4 0 0 90 512 1 1
    VPS11 RHOBTB2 0 0 0 219 1 1
    VPS11 ARF1 0 0 134 309 1 1
    VPS11 LRSAM1 192 0 75 261 1 2
    VPS11 MSANTD3 0 0 0 189 1 1
    VPS11 UBE2D3 0 0 85 275 1 1
    VPS11 ZNF645 0 0 150 203 1 1
    VPS11 NDN 0 0 487 487 1 1
    VPS11 GSG2 0 0 0 652 1 1
    VPS11 ARL14 0 0 45 232 1 1
    VPS11 NSF 0 0 422 664 1 1
    VPS11 COX5A 0 0 107 172 1 1
    VPS11 ABHD14A 0 0 150 224 1 1
    VPS11 CLTCL1 0 0 0 467 1 1
    VPS11 IL6 0 0 166 165 1 1
    VPS11 PIK3C3 0 0 362 810 1 2
    VPS11 TRIM7 0 0 108 163 1 1
    VPS11 ZNF486 0 0 235 235 1 1
    VPS11 RAB12 0 0 0 324 1 2
    VPS11 VPS4A 0 0 164 254 1 1
    VPS11 SCPEP1 0 0 0 165 1 1
    VPS11 WDSUB1 0 0 161 191 1 1
    VPS11 COG6 0 0 108 600 1 1
    VPS11 C5orf34 0 0 184 183 1 1
    VPS11 L1CAM 0 0 61 157 1 1
    VPS11 TRAPPC8 0 0 145 555 1 1
    VPS11 RRAS 0 0 0 213 1 1
    VPS11 ZNF518A 0 0 165 165 1 1
    VPS11 SORT1 0 0 499 550 1 1
    VPS11 DCTN2 0 0 103 275 1 1
    VPS11 UBL4B 0 0 0 158 1 1
    VPS11 RHOU 0 0 0 219 1 1
    VPS11 MTOR 0 0 134 344 1 2
    VPS11 AP1B1 0 0 0 155 1 1
    VPS11 RNF145 0 0 112 180 1 1
    VPS11 TMEM181 0 0 57 174 1 1
    VPS11 EXOC8 0 0 174 331 1 1
    VPS11 RANBP17 271 0 0 289 1 1
    VPS11 ARL8A 0 0 193 529 1 1
    VPS11 TMEM200C 0 0 285 479 1 1
    VPS11 HRAS 49 0 0 219 1 1
    VPS11 MAP1LC3A 0 0 107 196 1 2
    VPS11 CTNNB1 0 0 147 180 1 1
    VPS11 WDR26 0 0 0 163 1 1
    VPS11 ATP6V1B1 0 0 180 382 1 1
    VPS11 XPO1 0 0 45 150 1 1
    VPS11 TBC1D22B 0 0 0 198 1 1
    VPS11 RAB17 0 0 0 518 1 1
    VPS11 CSNK1G1 0 0 0 178 1 1
    VPS11 ENSG00000260371 0 0 0 331 1 1
    VPS11 RNF24 0 0 160 198 1 1
    VPS11 TGFBRAP1 880 0 893 999 1 1
    VPS11 ARL1 0 0 0 208 1 1
    VPS11 RHOBTB1 0 0 0 219 1 1
    VPS11 MCCC1 0 0 0 197 1 1
    VPS11 RAB5A 0 0 690 907 1 2
    VPS11 COG4 0 0 117 596 1 1
    VPS11 RAB5B 0 0 76 721 1 1
    VPS11 NEDD4 0 0 96 160 1 2
    VPS11 ATP6V1H 0 0 124 217 1 1
    VPS11 EDN1 0 0 347 347 1 1
    VPS11 RINT1 0 0 143 389 1 1
    VPS11 BAG3 0 0 72 168 1 2
    VPS11 TRPM7 0 0 44 218 1 1
    VPS11 ARF3 0 0 0 229 1 1
    VPS11 ENSG00000263136 0 0 123 283 1 1
    VPS11 CTSL 0 0 185 221 1 1
    VPS11 SEC24B 0 0 91 184 1 1
    VPS11 CXCL8 0 0 195 195 1 1
    VPS11 DYNLL1 0 0 57 174 1 1
    VPS11 RAB8A 0 0 134 257 1 2
    VPS11 SERPINH1 0 0 134 176 1 1
    VPS11 MCOLN1 0 0 181 279 1 1
    VPS11 TRIM23 0 0 75 363 1 1
    VPS11 PHF7 0 0 134 183 1 1
    VPS11 C7orf60 274 0 0 274 1 1
    VPS11 ATP6V0D1 0 0 164 257 1 1
    VPS11 MED29 0 0 379 379 1 1
    VPS11 RAB9A 0 0 72 833 1 2
    VPS11 CPVL 0 0 0 317 1 1
    VPS11 RLIM 0 0 141 208 1 1
    VPS11 LTN1 0 0 157 192 1 1
    VPS11 VIPAS39 0 0 518 781 1 1
    VPS11 ZFAND4 0 0 137 246 1 1
    VPS11 EXOC2 0 0 96 303 1 1
    VPS11 SKIV2L 0 0 66 183 1 1
    VPS11 POLR3B 0 0 95 182 1 1
    VPS11 RNF126 0 0 134 204 1 1
    VPS11 DIRAS1 0 0 0 213 1 1
    VPS11 VAMP8 0 0 213 349 1 2
    VPS11 LIMD1 0 0 156 170 1 1
    VPS11 UBE4A 0 0 120 353 1 1
    VPS11 HGS 0 0 166 270 1 2
    VPS11 AGR2 0 0 114 150 1 1
    VPS11 ZFYVE19 0 0 127 199 1 1
    VPS11 RNF111 0 0 68 158 1 1
    VPS11 HUWE1 0 0 139 419 1 1
    VPS11 NTSR1 0 0 536 536 1 1
    VPS11 CAMP 0 0 194 255 1 1
    VPS11 RNF115 0 0 113 186 1 1
    VPS11 RNF149 0 0 108 173 1 1
    VPS11 CUL2 0 0 0 200 1 1
    VPS11 RAF1 0 0 45 166 1 2
    VPS11 VAMP4 0 0 72 221 1 1
    VPS11 CDC26 0 0 93 153 1 1
    VPS11 RAB10 0 0 67 170 1 1
    VPS11 ARF5 0 0 0 229 1 1
    VPS11 KLHDC2 0 0 0 156 1 1
    VPS11 TRIM40 0 0 95 151 1 1
    VPS11 CTSA 0 0 90 352 1 1
    VPS11 NLRP4 0 0 425 425 1 1
    VPS11 RNF10 0 0 113 190 1 1
    VPS11 RNF40 0 0 74 182 1 1
    VPS11 ENSG00000273637 0 0 0 165 1 1
    VPS11 EPS15 0 0 89 254 1 1
    VPS11 ZNF787 0 0 218 218 1 1
    VPS11 ATP6V0C 0 0 241 485 1 2
    VPS11 AP3D1 0 0 157 387 1 1
    VPS11 RAB2A 0 0 249 478 1 1
    VPS11 STX5 0 0 290 488 1 1
    VPS11 CCDC186 0 0 102 179 1 1
    VPS11 ZYG11A 0 0 134 330 1 1
    VPS11 DEFB103A 0 0 282 282 1 1
    VPS11 PPP1CC 0 0 46 207 1 1
    VPS11 OPLAH 0 0 0 207 1 1
    VPS11 VPS53 0 0 281 682 1 1
    VPS11 LAMP1 0 0 391 527 1 2
    VPS11 RAB4A 0 0 112 336 1 1
    VPS11 DAB2IP 0 0 0 178 1 2
    VPS11 RNF214 0 0 155 169 1 1
    VPS11 MTMR2 0 0 74 187 1 1
    VPS11 RB1CC1 0 0 169 169 1 2
    VPS11 FGD5 0 0 0 190 1 1
    VPS11 DOLK 0 0 0 161 1 1
    VPS11 ST13 0 0 66 214 1 2
    VPS11 BOLA2 0 0 0 249 1 1
    VPS11 UBBP4 0 0 0 158 1 1
    VPS11 RTN4RL2 0 0 183 197 1 1
    VPS11 RSG1 0 0 0 213 1 1
    VPS11 OASL 0 0 0 158 1 1
    VPS11 CAND1 0 0 57 186 1 1
    VPS11 UBA1 0 0 70 164 1 1
    VPS11 ANP32A 0 0 171 177 1 1
    VPS11 DDX39A 0 0 0 341 1 1
    VPS11 UBD 0 0 0 158 1 1
    VPS11 ANAPC11 0 0 119 319 1 1
    VPS11 VPS39 871 900 983 999 1 1
    VPS11 ZNRF4 0 0 113 186 1 1
    VPS11 GOLPH3 0 0 244 243 1 1
    VPS11 RUFY1 0 0 92 219 1 1
    VPS11 DZIP3 0 0 91 166 1 1
    VPS11 PTPLB 0 0 122 197 1 1
    VPS11 DCTN4 0 0 202 301 1 1
    VPS11 MED21 0 0 0 183 1 1
    VPS11 KLHL21 0 0 113 267 1 1
    VPS11 ACP5 0 0 0 265 1 1
    VPS11 UBXN7 0 0 0 208 1 1
    VPS11 INPP5F 0 0 0 165 1 1
    VPS11 PIK3CA 0 0 45 171 1 2
    VPS11 RAD18 0 0 95 256 1 1
    VPS11 PARVA 314 0 0 314 1 1
    VPS11 TRAPPC9 0 0 181 519 1 1
    VPS11 VPS13B 0 0 0 164 1 1
    VPS11 CHMP4C 0 0 0 332 1 1
    VPS11 MYC 0 0 193 193 1 2
    VPS11 ARL8B 0 0 394 646 1 1
    VPS11 TBC1D24 0 0 76 236 1 1
    VPS11 PI3 0 0 245 244 1 1
    VPS11 BLOC1S1 0 0 195 507 1 1
    VPS11 LONRF1 0 0 122 181 1 1
    VPS11 UBE2D1 0 0 93 240 1 1
    VPS11 RIT1 0 0 0 213 1 1
    VPS11 COG1 0 0 140 190 1 1
    VPS11 CLTC 0 0 294 622 1 1
    VPS11 TYR 0 0 323 323 1 1
    VPS11 RDX 270 0 457 589 1 1
    VPS11 CTSH 0 0 49 223 1 1
    VPS11 HSPA4 0 0 91 151 1 1
    VPS11 UBE4B 0 0 90 274 1 1
    VPS11 TRIP13 0 0 0 317 1 1
    VPS11 TRIM35 0 0 95 151 1 1
    VPS11 DEFB103B 0 0 282 282 1 1
    VPS11 RNF148 0 0 141 217 1 1
    VPS11 PIF1 0 0 77 339 1 1
    VPS11 HSP90B1 0 0 0 288 1 1
    VPS11 RPTOR 0 0 142 225 1 2
    VPS11 ZUFSP 270 0 0 270 1 1
    VPS11 ATP6V1D 0 0 125 177 1 1
    VPS11 VAMP1 0 0 0 195 1 1
    VPS11 DDX1 0 0 0 186 1 1
    VPS11 CHEK2 0 0 57 181 1 1
    VPS11 EXOC6 0 0 181 275 1 1
    VPS11 PDP1 0 0 0 155 1 1
    VPS11 RAC3 0 0 0 219 1 1
    VPS11 ATG4A 0 0 160 288 1 2
    VPS11 MTM1 0 0 90 201 1 1
    VPS11 TBC1D15 0 0 107 254 1 1
    VPS11 GULP1 0 0 81 150 1 1
    VPS11 ARL5C 0 0 0 229 1 1
    VPS11 RNF144B 0 0 90 185 1 1
    VPS11 BLOC1S2 0 0 120 384 1 1
    VPS11 RAB31 0 0 0 518 1 1
    VPS11 GAK 0 0 95 247 1 1
    VPS11 ARL11 0 0 0 229 1 1
    VPS11 EPS15L1 0 0 0 222 1 1
    VPS11 RAB8B 0 0 66 198 1 2
    VPS11 RNF19A 0 0 89 184 1 1
    VPS11 EGF 0 0 261 261 1 1
    VPS11 MAGEH1 0 0 605 605 1 1
    VPS11 WRAP53 0 0 60 226 1 1
    VPS11 NSMAF 0 0 0 229 1 1
    VPS11 ARL9 0 0 0 229 1 1
    VPS11 GNPTAB 0 0 73 554 1 1
    VPS11 TRAPPC10 0 0 142 398 1 1
    VPS11 RNF17 0 0 96 173 1 1
    VPS11 NMNAT3 0 0 166 180 1 1
    VPS11 RAB6A 0 0 162 247 1 1
    VPS11 RAB38 0 0 108 245 1 1
    VPS11 VPS33A 767 900 821 999 1 1
    VPS11 ATP6V0A2 0 0 113 284 1 1
    VPS11 ARL4D 0 0 0 229 1 1
    VPS11 ATP6V0D2 0 0 75 178 1 1
    VPS11 VPS18 870 900 988 999 1 1
    VPS11 VPS52 0 0 245 690 1 1
    VPS11 IL2RG 0 0 323 323 1 1
    VPS11 SCFD1 0 0 171 623 1 1
    VPS11 C15orf57 0 0 193 193 1 1
    VPS11 XPNPEP2 0 0 95 157 1 1
    VPS11 OMG 0 0 486 495 1 1
    VPS11 TRAPPC11 0 0 0 316 1 1
    VPS11 GALNT18 0 0 96 158 1 1
    VPS11 BOLA2B 0 0 0 249 1 1
    VPS11 LGALS4 0 0 213 213 1 1
    VPS11 ZNF205 0 0 134 321 1 1
    VPS11 FANCM 0 0 0 151 1 1
    VPS11 TBC1D2 0 0 66 179 1 1
    VPS11 CCDC93 0 0 123 337 1 1
    VPS11 TBC1D22A 0 0 0 198 1 1
    VPS11 VPS54 0 0 275 684 1 1
    VPS11 CHMP3 0 0 142 353 1 1
    VPS11 TSEN54 0 0 0 311 1 1
    VPS11 DCTN3 0 0 122 316 1 1
    VPS11 CUL5 0 0 72 225 1 1
    VPS11 PPP1CB 0 0 0 207 1 1
    VPS11 CUX1 0 0 84 198 1 1
    VPS11 DNM2 0 0 138 252 1 1
    VPS11 LONRF3 0 0 128 187 1 1
    VPS11 MAP1LC3C 0 0 96 157 1 2
    VPS11 RHOB 0 0 0 229 1 1
    VPS11 EXOC3L4 0 0 0 180 1 1
    VPS11 RAB3GAP2 0 0 0 172 1 1
    VPS11 RAB9B 0 0 0 826 1 1
    VPS11 UBE2D4 0 0 0 196 1 1
    VPS11 HYOU1 0 0 147 565 1 1
    VPS11 SH3PXD2A 0 0 0 167 1 1
    VPS11 RAB32 0 0 142 328 1 2
    VPS11 SNAP47 0 0 66 162 1 1
    VPS11 WAC 0 0 134 187 1 1
    VPS11 RAP2B 0 0 0 213 1 1
    VPS11 CDH1 0 0 113 151 1 1
    VPS11 VPS26A 0 0 186 432 1 1
    VPS11 VPS35 0 0 150 638 1 1
    VPS11 RERG 0 0 0 213 1 1
    VPS11 RAP1B 0 0 0 222 1 1
    VPS11 SH3PXD2B 0 0 0 167 1 1
    VPS11 ENSG00000272822 0 0 0 229 1 1
    VPS11 IL4 0 0 66 175 1 1
    VPS11 C6orf89 0 0 0 189 1 1
    VPS11 TECR 0 0 0 303 1 1
    VPS11 NFXL1 0 0 120 157 1 1
    VPS11 VAMP2 0 0 53 206 1 1
    VPS11 UBOX5 0 0 123 267 1 1
    VPS11 GGH 0 0 52 203 1 1
    VPS11 PEX12 0 0 74 212 1 1
    VPS11 ARL17A 0 0 0 229 1 1
    VPS11 RNF123 0 0 125 259 1 1
    VPS11 RNF183 0 0 134 173 1 1
    VPS11 DBN1 0 0 159 158 1 1
    VPS11 UBAP2 0 0 112 173 1 1
    VPS11 KIF16B 0 0 123 194 1 1
    VPS11 ENSG00000272617 0 0 206 446 1 1
    VPS11 ALB 0 0 211 211 1 1
    VPS11 NAPB 0 0 0 402 1 1
    VPS11 RNF44 0 0 152 214 1 1
    VPS11 RNF207 0 0 123 163 1 1
    VPS11 VPS8 767 0 859 999 1 1
    VPS11 HERC4 0 0 95 219 1 1
    VPS11 TRIM41 0 0 103 159 1 1
    VPS11 CUL1 0 0 82 224 1 1
    VPS11 ENSG00000255863 0 0 0 229 1 1
    VPS11 RABEP1 0 0 207 257 1 1
    VPS11 CTNS 0 0 81 172 1 1
    VPS11 SEC22C 0 0 0 159 1 1
    VPS11 TRAPPC3 0 0 206 502 1 1
    VPS11 RAP2A 0 0 0 213 1 1
    VPS11 AACS 0 0 108 151 1 1
    VPS11 UFD1L 0 0 70 222 1 1
    VPS11 TFEB 0 0 414 478 1 2
    VPS11 KLHDC1 0 0 0 156 1 1
    VPS11 EXOC5 0 0 151 369 1 1
    VPS11 HPGDS 0 0 157 156 1 1
    VPS11 RHOV 0 0 0 219 1 1
    VPS11 KIF13A 0 0 134 184 1 1
    VPS11 CLEC16A 0 0 96 181 1 2
    VPS11 VPS13C 0 0 0 207 1 1
    VPS11 PKNOX2 0 0 167 190 1 1
    VPS11 MSN 270 0 457 587 1 1
    VPS11 ACTB 0 0 188 246 1 1
    VPS11 ATG13 0 0 167 229 1 2
    VPS11 ARHGDIA 0 0 538 549 1 1
    VPS11 EXOC3 0 0 203 394 1 1
    VPS11 GLO1 0 0 107 205 1 1
    VPS11 ARL6 0 0 0 229 1 1
    VPS11 ULK4 0 0 112 157 1 1
    VPS11 RND1 0 0 0 219 1 1
    VPS11 GTF2I 259 0 0 258 1 1
    VPS11 EXOC6B 0 0 0 151 1 1
    VPS11 MKRN2 0 0 123 204 1 1
    VPS11 TRIM73 0 0 151 156 1 1
    VPS11 SQSTM1 0 0 299 374 1 2
    VPS11 RNF5 0 0 114 356 1 1
    VPS11 SLC37A4 0 0 167 167 1 1
    VPS11 ATG9A 0 0 141 478 1 2
    VPS11 CRYGD 0 0 453 453 1 1
    VPS11 ENSG00000249884 0 0 142 353 1 1
    VPS11 ZFYVE20 0 0 100 657 1 1
    VPS11 VPS28 0 0 168 498 1 1
    VPS11 FXYD6 0 0 185 203 1 1
    VPS11 SLC32A1 0 0 0 156 1 1
    VPS11 ERAS 0 0 0 213 1 1
    VPS11 PJA1 0 0 103 200 1 1
    VPS11 RAB24 0 0 69 532 1 2
    VPS11 RHOA 0 0 242 390 1 1
    VPS11 GPAA1 0 0 0 302 1 1
    VPS11 UBE2L3 270 0 0 294 1 1
    VPS11 HSPA8 0 0 81 167 1 2
    VPS11 CCNY 0 0 81 162 1 2
    VPS11 STX6 213 0 195 856 1 1
    VPS11 STX1A 462 0 74 537 1 1
    VPS11 DEF8 0 0 125 179 1 1
    VPS11 RHOQ 0 0 0 219 1 1
    VPS11 CDKN2AIPNL 0 0 184 195 1 1
    VPS11 UBE2N 0 0 81 171 1 1
    VPS11 ZYG11B 0 0 148 356 1 1
    VPS11 KLHDC10 0 0 45 160 1 1
    VPS11 PMCH 0 0 142 209 1 1
    VPS11 ENSG00000271810 0 0 0 219 1 1
    VPS11 RAB1A 0 0 202 277 1 2
    VPS11 WDR48 0 0 0 150 1 1
    VPS11 ISOC2 379 0 0 379 1 1
    VPS11 RHOG 0 0 0 219 1 1
    VPS11 UBAP1 0 0 171 179 1 1
    VPS11 UMPS 0 0 0 284 1 1
    VPS11 ATP6V0B 0 0 92 150 1 1
    VPS11 ZER1 0 0 134 402 1 1
    VPS11 PLEKHF2 0 0 90 218 1 1
    VPS11 RASL12 0 0 0 213 1 1
    VPS11 LSM1 177 0 0 192 1 1
    VPS11 STX18 0 0 279 375 1 1
    VPS11 CCT4 0 0 123 195 1 1
    VPS11 OCA2 0 0 125 271 1 1
    VPS11 VPS16 783 900 989 999 1 1
    VPS11 TRAPPC4 0 0 243 557 1 1
    VPS11 HBS1L 0 0 0 205 1 1
    VPS11 GABARAPL1 0 0 264 386 1 2
    VPS11 SEC31A 0 0 0 152 1 1
    VPS11 RALB 0 0 0 233 1 1
    VPS11 VCP 0 0 95 205 1 2
    VPS11 RNF182 0 0 123 163 1 1
    VPS11 LAMP2 0 0 203 289 1 2
    VPS11 CTSF 0 0 150 348 1 1
    VPS11 ARL10 0 0 0 208 1 1
    VPS11 UBXN8 0 0 0 184 1 1
    VPS11 HIP1 0 0 0 214 1 1
    VPS11 GRN 0 0 219 219 1 1
    VPS11 GOLGA2 0 0 138 161 1 1
    VPS11 TPP2 0 0 0 152 1 1
    VPS11 TRPM6 0 0 54 226 1 1
    VPS11 RILP 270 0 218 423 1 1
    VPS11 RABL2A 0 0 0 390 1 1
    VPS11 MNT 0 0 0 165 1 1
    VPS11 BMI1 270 0 0 295 1 1
    VPS11 ARIH1 0 0 93 360 1 1
    VPS11 KIF3C 0 0 90 204 1 1
    VPS11 EIF3M 0 0 0 164 1 1
    VPS11 TTC3 0 0 97 192 1 1
    VPS11 EXOC7 0 0 170 433 1 1
    VPS11 RAP2C 0 0 0 213 1 1
    VPS11 SH3RF2 0 0 123 181 1 1
    VPS11 DND1 0 0 337 386 1 1
    VPS11 TCIRG1 0 0 96 231 1 1
    VPS11 CSNK1G2 0 0 0 178 1 1
    VPS11 EHD4 0 0 49 196 1 1
    VPS11 RASD1 0 0 0 213 1 1
    VPS11 MON1B 192 0 247 811 1 1
    VPS11 NCKIPSD 0 0 0 161 1 1
    VPS11 DPH7 0 0 54 199 1 1
    VPS11 RTN4R 0 0 415 425 1 1
    VPS11 RNF113B 0 0 151 180 1 1
    VPS11 SNAP29 0 0 267 464 1 2
    VPS11 TEX2 0 0 0 159 1 1
    VPS11 ZSWIM2 0 0 127 220 1 1
    VPS11 COG8 0 0 193 438 1 1
    VPS11 ARL17B 0 0 0 229 1 1
    VPS11 ULK2 0 0 112 154 1 2
    VPS11 PIK3CG 0 0 0 167 1 1
    VPS11 ZNF213 0 0 219 340 1 1
    VPS11 BLOC1S4 0 0 267 332 1 1
    VPS11 SNX1 0 0 205 275 1 1
    VPS11 MEX3D 0 0 116 180 1 1
    VPS11 RABEPK 0 0 0 185 1 1
    VPS11 COPE 0 0 108 192 1 1
    VPS11 YKT6 0 0 532 789 1 1
    VPS11 FUT2 0 0 57 202 1 1
    VPS11 UBE3C 0 0 124 435 1 1
    VPS11 GOLGB1 0 0 155 162 1 1
    VPS11 ARL4A 0 0 0 229 1 1
    VPS11 ENOX2 0 0 120 177 1 1
    VPS11 RHOT1 0 0 0 222 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0000166 Molecular Function nucleotide binding enables IEA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0019904 Molecular Function protein domain specific binding enables IPI
    GO:0030674 Molecular Function protein-macromolecule adaptor activity enables IBA
    GO:0019905 Molecular Function syntaxin binding enables IDA
    GO:0061630 Molecular Function ubiquitin protein ligase activity enables IMP
    GO:0008270 Molecular Function zinc ion binding enables IEA
    GO:0006914 Biological Process autophagy involved_in IEA
    GO:0034058 Biological Process endosomal vesicle fusion involved_in IMP
    GO:0034058 Biological Process endosomal vesicle fusion involved_in NAS
    GO:0007032 Biological Process endosome organization involved_in IBA
    GO:0008333 Biological Process endosome to lysosome transport involved_in IMP
    GO:0006886 Biological Process intracellular protein transport involved_in IEA
    GO:0033147 Biological Process negative regulation of intracellular estrogen receptor signaling pathway involved_in IGI
    GO:0048284 Biological Process organelle fusion involved_in IBA
    GO:2000643 Biological Process positive regulation of early endosome to late endosome transport involved_in IMP
    GO:0045732 Biological Process positive regulation of protein catabolic process involved_in IMP
    GO:1903955 Biological Process positive regulation of protein targeting to mitochondrion involved_in HMP
    GO:0016567 Biological Process protein ubiquitination involved_in IMP
    GO:0035542 Biological Process regulation of SNARE complex assembly involved_in NAS
    GO:1902115 Biological Process regulation of organelle assembly involved_in IMP
    GO:0031647 Biological Process regulation of protein stability involved_in HMP
    GO:0007033 Biological Process vacuole organization involved_in IBA
    GO:0006904 Biological Process vesicle docking involved in exocytosis involved_in IBA
    GO:0033263 Cellular Component CORVET complex part_of NAS
    GO:0030897 Cellular Component HOPS complex part_of IBA
    GO:0030897 Cellular Component HOPS complex part_of IDA
    GO:0030897 Cellular Component HOPS complex part_of NAS
    GO:0005776 Cellular Component autophagosome located_in IEA
    GO:0030136 Cellular Component clathrin-coated vesicle located_in IEA
    GO:0005769 Cellular Component early endosome colocalizes_with IDA
    GO:0030139 Cellular Component endocytic vesicle located_in IDA
    GO:0005768 Cellular Component endosome is_active_in IBA
    GO:0005768 Cellular Component endosome located_in IDA
    GO:0010008 Cellular Component endosome membrane located_in TAS
    GO:0005770 Cellular Component late endosome colocalizes_with IDA
    GO:0005770 Cellular Component late endosome located_in IDA
    GO:0031902 Cellular Component late endosome membrane located_in IEA
    GO:0005765 Cellular Component lysosomal membrane located_in HDA
    GO:0005764 Cellular Component lysosome colocalizes_with IDA
    GO:0005764 Cellular Component lysosome located_in IDA
    Pathways
    Name DB ID
    Network map of SARS-CoV-2 signaling pathway (WP5115) WikiPathways WP5115_r124648
    Ebola virus infection in host (WP4217) WikiPathways WP4217_r120623
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_165452 1 miscRNA transcript variant 12 NC_000011 Reference
    NR_165447 1 miscRNA transcript variant 7 NC_000011 Reference
    XR_947859 3 miscRNA transcript variant X1 NC_000011 Reference
    NR_165453 1 miscRNA transcript variant 13 NC_000011 Reference
    NR_165449 1 miscRNA transcript variant 9 NC_000011 Reference
    NR_165454 1 miscRNA transcript variant 14 NC_000011 Reference
    NR_165451 1 miscRNA transcript variant 11 NC_000011 Reference
    NR_165448 1 miscRNA transcript variant 8 NC_000011 Reference
    NR_165450 1 miscRNA transcript variant 10 NC_000011 Reference
    NM_001290185 2 mRNA transcript variant 2 NC_000011 Reference
    NM_001378218 1 mRNA transcript variant 3 NC_000011 Reference
    NM_001378219 1 mRNA transcript variant 4 NC_000011 Reference
    NM_021729 6 mRNA transcript variant 1 NC_000011 Reference
    NM_001378220 1 mRNA transcript variant 5 NC_000011 Reference
    NM_001378221 1 mRNA transcript variant 6 NC_000011 Reference
    XM_047427256 1 mRNA transcript variant X2 NC_000011 Reference