MEG3

maternally expressed 3
General Information
Name maternally expressed 3
Alias
  • Very putative protein from MEG3 locus
  • gene trap locus 2
  • long intergenic non-protein coding RNA 23
  • maternally expressed 3 (non-protein coding)
Synonyms GTL2 NCRNA00023 LINC00023 onco-lncRNA-83 FP504 PRO0518 PRO2160 prebp1
Gene_family Long non-coding RNAs with non-systematic symbols|MicroRNA non-coding host genes
organism Homo sapiens
entrez_id 55384
location 14q32.2
transcript_count 19
exon_count 13
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expression is lost in multiple cancer cell lines of various tissue origins. It inhibits tumor cell proliferation in vitro. It also interacts with the tumor suppressor p53, and regulates p53 target gene expression. Its deletion enhances angiogenesis in vivo. Many experimental evidences demonstrate that this gene is a lncRNA tumor suppressor. [provided by RefSeq, Mar 2012]
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    MEG3 BioGRID RSPH1 GeneID BioGRID Two-hybrid
    MEG3 BioGRID GSK3B GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    MEG3 BioGRID CTNNB1 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    MEG3 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    MEG3 BioGRID STAT3 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    StringDB
    A B experiments database textmining combined score hadb nhadb
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0141180 Molecular Function dsDNA-RNA triple helix-forming chromatin adaptor activity enables IDA
    GO:0006325 Biological Process chromatin organization involved_in IEA
    GO:0035195 Biological Process miRNA-mediated post-transcriptional gene silencing involved_in IEA
    GO:0030308 Biological Process negative regulation of cell growth involved_in IEA
    GO:0016442 Cellular Component RISC complex part_of IEA
    Pathways
    Name DB ID
    lncRNA-mediated mechanisms of therapeutic resistance (WP3672) WikiPathways WP3672_r123394
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_046467 1 ncRNA transcript variant 10 NC_000014 Reference
    NR_046465 2 ncRNA transcript variant 8 NC_000014 Reference
    NR_046472 1 ncRNA transcript variant 15 NC_000014 Reference
    NR_046471 1 ncRNA transcript variant 14 NC_000014 Reference
    NR_033359 1 ncRNA transcript variant 5 NC_000014 Reference
    NR_003530 2 ncRNA transcript variant 2 NC_000014 Reference
    NR_033358 1 ncRNA transcript variant 4 NC_000014 Reference
    NR_002766 2 ncRNA transcript variant 1 NC_000014 Reference
    NR_046470 2 ncRNA transcript variant 13 NC_000014 Reference
    NR_033360 1 ncRNA transcript variant 6 NC_000014 Reference
    NR_046464 1 ncRNA transcript variant 7 NC_000014 Reference
    NR_046469 1 ncRNA transcript variant 12 NC_000014 Reference
    NR_046466 1 ncRNA transcript variant 9 NC_000014 Reference
    NR_046473 1 ncRNA transcript variant 16 NC_000014 Reference
    NR_190993 1 ncRNA transcript variant 17 NC_000014 Reference
    NR_190996 1 ncRNA transcript variant 20 NC_000014 Reference
    NR_190995 1 ncRNA transcript variant 19 NC_000014 Reference
    NR_190994 1 ncRNA transcript variant 18 NC_000014 Reference
    NR_003531 3 ncRNA transcript variant 3 NC_000014 Reference