WDR41

WD repeat domain 41
General Information
Name WD repeat domain 41
Alias
  • WD repeat-containing protein 41
Synonyms FLJ10904 MSTP048
Gene_family SWC tripartite complex|WD repeat domain containing
organism Homo sapiens
entrez_id 55255
location 5q13.3-q14.1
transcript_count 9
exon_count 17
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Enables GTPase activator activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in regulation of autophagy. Located in cytoplasm. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Mar 2025]
      Stringdb WD repeat-containing protein 41; Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72- SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity; WD repeat domain containing
      nextProt Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (PubMed:32303654). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    WDR41 BioGRID CEACAM6 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID E GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID C9orf72 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex
    WDR41 BioGRID RPA3 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RPA2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RPA1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ORF7a GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ORF7b GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ORF6 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ORF3a GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID M GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID Rab18 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID CLEC16A GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID IGF1R GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID FGFR4 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID FGFR1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID EPHA8 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ALK GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID PRKN GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID ARL10 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID C9orf78 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RAB7A GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID CDC42 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RHOH GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RHOG GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RHOA GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RHOJ GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RHOD GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RHOQ GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RND2 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RAC3 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RAC1 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID RB1CC1 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID FURIN GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID BSG GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ANPEP GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID TMPRSS11B GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID TMPRSS4 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID CLEC4E GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID IFITM3 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID IFITM1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID KRTCAP3 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID MRAP2 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID ATP13A3 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID SLC27A6 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID TSPAN5 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID PICK1 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID DNAJC7 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID TKT GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID MCM5 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID APBB2 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID LRRC59 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID LAMTOR1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID HSD17B11 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID B3GAT1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID LAMP3 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID TMT1A GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID PANX1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RAB35 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID CKAP4 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID SEC61B GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID BCAP31 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID NUP155 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RAB9A GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID EBAG9 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RAB11A GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID STX7 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID AKAP1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID REEP5 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID SEC62 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID STX4 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID STIM1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID SSR1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RPN2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RPN1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RAB5C GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RAB5A GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RAB4A GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RAB3B GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RAB2A GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID PXMP2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID MARCKS GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID LMAN1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID LAMP2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID GJD3 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID LNPK GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID HSD3B7 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID DERL1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ELOVL5 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ERGIC1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID KRAS GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID EMD GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID CYP2C9 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID CXADR GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ATP2A1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ARF6 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID DNAJC25 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID HSPA12B GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID DNAJC1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID DNAJC16 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID SEC63 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID DNAJB4 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID PRKACA GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID SLC25A46 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RHOT2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID MAVS GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID EXD2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID RMDN3 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID OCIAD1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID MARCHF5 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID FIS1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID MTCH2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID MTCH1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID FKBP8 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID MFN2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID ST7 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID PTPN1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID OTULINL GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
    WDR41 BioGRID SMCR8 GeneID BioGRID Co-purification
    WDR41 BioGRID ATG101 GeneID BioGRID Co-purification
    WDR41 BioGRID COX14 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID TOMM22 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID PTRH2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID TOMM20 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID MGST3 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID LAMP1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID CANX GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID TMEM17 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID TCTN2 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID TMEM216 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID NPHP1 GeneID BioGRID Proximity Label-MS
    WDR41 BioGRID MMS19 GeneID BioGRID Affinity Capture-MS
    StringDB
    A B experiments database textmining combined score hadb nhadb
    WDR41 ATG7 0 0 184 277 1 2
    WDR41 DGKI 0 360 0 360 1 1
    WDR41 FRA10AC1 0 0 362 622 1 1
    WDR41 DCTN1 0 0 134 164 1 1
    WDR41 SCML1 0 0 298 298 1 1
    WDR41 EIF2B3 0 540 0 540 1 1
    WDR41 RAB12 0 0 363 363 1 2
    WDR41 PIK3C3 0 0 94 161 1 2
    WDR41 CHMP2B 0 0 391 454 1 2
    WDR41 TAF4 0 0 136 269 1 1
    WDR41 LHFP 0 0 210 214 1 1
    WDR41 BOLA2B 0 0 0 190 1 1
    WDR41 CEMIP 0 0 140 230 1 1
    WDR41 CTSD 0 0 118 168 1 2
    WDR41 MTOR 0 0 123 657 1 2
    WDR41 RIC1 0 720 0 720 1 1
    WDR41 HILPDA 0 0 140 163 1 1
    WDR41 ZCCHC18 0 0 0 195 1 1
    WDR41 ATXN2 0 0 391 455 1 1
    WDR41 VDAC3 0 0 103 159 1 1
    WDR41 RAB32 0 0 210 231 1 2
    WDR41 ARPP21 0 0 155 154 1 1
    WDR41 PQLC2 0 0 450 450 1 1
    WDR41 PDE8B 0 0 370 413 1 1
    WDR41 LCAT 0 0 87 181 1 1
    WDR41 HLF 0 0 158 157 1 1
    WDR41 RGP1 0 720 0 720 1 1
    WDR41 RAB25 0 0 208 208 1 2
    WDR41 GCFC2 0 0 151 152 1 1
    WDR41 RAB7B 0 0 293 293 1 1
    WDR41 MADD 0 0 730 730 1 1
    WDR41 MSH3 0 0 74 291 1 1
    WDR41 MAD1L1 0 0 142 274 1 1
    WDR41 IKBKE 0 0 0 188 1 1
    WDR41 ZCCHC12 0 0 216 341 1 1
    WDR41 BOLA2-SMG1P6 0 0 0 190 1 1
    WDR41 SNTB2 0 0 171 171 1 1
    WDR41 THADA 0 0 123 277 1 1
    WDR41 ELMO1 0 720 0 720 1 1
    WDR41 ZNF250 0 0 144 175 1 1
    WDR41 CYHR1 0 0 260 368 1 1
    WDR41 GPCPD1 0 0 234 235 1 1
    WDR41 TBK1 0 0 405 638 1 2
    WDR41 ATG2B 0 0 52 246 1 2
    WDR41 MTMR6 0 0 193 193 1 1
    WDR41 GIPC2 0 0 212 294 1 1
    WDR41 CSGALNACT1 0 0 157 156 1 1
    WDR41 RESP18 0 0 243 256 1 1
    WDR41 DOCK1 0 720 0 720 1 1
    WDR41 HECW2 0 0 166 252 1 1
    WDR41 RRAGB 0 0 150 203 1 2
    WDR41 RRAGA 0 0 142 195 1 2
    WDR41 IARS 0 0 113 213 1 1
    WDR41 DET1 0 0 181 181 1 1
    WDR41 MMS19 270 0 153 694 1 1
    WDR41 TOMM20 117 0 66 271 1 1
    WDR41 RAB5A 0 0 264 264 1 2
    WDR41 RAB11A 0 0 370 370 1 1
    WDR41 CACUL1 0 0 107 302 1 1
    WDR41 SMG1 0 0 0 190 1 1
    WDR41 RAP1A 0 360 0 360 1 1
    WDR41 SLC12A7 0 0 140 251 1 1
    WDR41 GTPBP2 0 0 123 168 1 1
    WDR41 ATG5 0 0 153 223 1 2
    WDR41 ABCG8 0 0 81 174 1 1
    WDR41 RBM47 0 0 167 239 1 1
    WDR41 ATP8A2 0 0 171 211 1 1
    WDR41 IQSEC3 0 0 242 358 1 1
    WDR41 SPATA31E1 0 0 218 218 1 1
    WDR41 TENM4 0 0 142 230 1 1
    WDR41 MOB3C 0 0 0 424 1 1
    WDR41 SAMD9 0 0 150 221 1 1
    WDR41 CLTC 0 0 90 214 1 1
    WDR41 RGS9 0 0 113 188 1 1
    WDR41 FUS 0 0 205 205 1 1
    WDR41 SMOC2 0 0 123 199 1 1
    WDR41 IGSF21 0 0 244 334 1 1
    WDR41 RAB8B 0 0 134 224 1 2
    WDR41 IGLON5 0 0 193 317 1 1
    WDR41 SMCR8 847 800 988 999 1 2
    WDR41 MBOAT2 0 0 155 154 1 1
    WDR41 ETS1 0 0 0 171 1 1
    WDR41 LHX3 0 0 122 210 1 1
    WDR41 PDZRN3 0 0 170 169 1 1
    WDR41 LINGO2 0 0 57 626 1 1
    WDR41 RAB31 0 0 153 205 1 1
    WDR41 TMEM55B 0 0 219 692 1 1
    WDR41 ITIH5 0 0 180 179 1 1
    WDR41 UBQLN2 0 0 310 325 1 2
    WDR41 OPTN 0 0 554 655 1 2
    WDR41 FLCN 0 0 334 756 1 1
    WDR41 IFNB1 0 0 0 189 1 1
    WDR41 IMMT 0 0 95 342 1 1
    WDR41 RGL2 0 0 183 298 1 1
    WDR41 ALS2 0 0 137 174 1 1
    WDR41 PIK3R6 0 0 210 210 1 1
    WDR41 OR5A1 0 0 337 437 1 1
    WDR41 ATAD3B 0 0 0 183 1 1
    WDR41 ZKSCAN3 0 0 167 167 1 2
    WDR41 RAB38 0 0 293 303 1 1
    WDR41 C1orf127 0 0 343 410 1 1
    WDR41 ULK1 0 0 400 400 1 2
    WDR41 TANC1 0 0 233 351 1 1
    WDR41 RAD51B 0 0 90 155 1 1
    WDR41 RAB6A 0 0 205 239 1 1
    WDR41 FLNC 0 0 167 167 1 1
    WDR41 FNIP1 0 0 260 280 1 1
    WDR41 PTBP3 270 0 0 270 1 1
    WDR41 TSPAN5 274 0 0 274 1 1
    WDR41 SNED1 0 0 150 335 1 1
    WDR41 CACNA2D4 0 0 165 295 1 1
    WDR41 DDA1 0 0 243 242 1 1
    WDR41 UBQLN1 0 0 66 183 1 2
    WDR41 PINK1 0 0 158 157 1 2
    WDR41 ATG10 0 0 150 226 1 2
    WDR41 RAB3A 0 0 142 168 1 1
    WDR41 SRPK1 0 0 113 174 1 1
    WDR41 NDUFB6 0 0 49 602 1 1
    WDR41 RALYL 0 0 244 359 1 1
    WDR41 KNDC1 0 720 0 720 1 1
    WDR41 MAP1LC3B 0 0 171 172 1 2
    WDR41 ZNF394 0 0 281 281 1 1
    WDR41 YBEY 0 0 112 184 1 1
    WDR41 AGFG1 0 0 293 337 1 1
    WDR41 GAS2 0 0 141 160 1 1
    WDR41 TMEFF1 0 0 66 348 1 1
    WDR41 ST7 226 0 0 225 1 1
    WDR41 SOD1 0 0 160 159 1 1
    WDR41 CAND1 0 0 113 151 1 1
    WDR41 MSANTD3-TMEFF1 0 0 0 254 1 1
    WDR41 TUBGCP6 0 0 191 330 1 1
    WDR41 TNIP2 0 0 143 163 1 1
    WDR41 ATAD3A 0 0 0 183 1 1
    WDR41 BOLA2 0 0 0 190 1 1
    WDR41 RRAGC 0 0 324 747 1 1
    WDR41 SRPK2 0 0 142 201 1 1
    WDR41 GRN 0 0 166 184 1 1
    WDR41 ZFP41 0 0 146 161 1 1
    WDR41 OR5A2 0 0 0 187 1 1
    WDR41 WDR45 0 0 96 186 1 2
    WDR41 RB1CC1 249 0 719 781 1 2
    WDR41 P2RX5 0 0 113 257 1 1
    WDR41 RAB39A 0 0 90 632 1 1
    WDR41 ADARB2 0 0 113 162 1 1
    WDR41 APOLD1 0 0 193 193 1 1
    WDR41 LAMP2 0 0 107 186 1 2
    WDR41 VCP 0 0 227 256 1 2
    WDR41 IFNK 0 0 54 437 1 1
    WDR41 SLCO4A1 0 0 134 166 1 1
    WDR41 GNG12 0 0 161 161 1 1
    WDR41 WDR4 0 0 232 368 1 1
    WDR41 RAB39B 0 800 690 973 1 2
    WDR41 SLC25A46 117 0 0 150 1 1
    WDR41 OTUD6B 0 0 203 203 1 1
    WDR41 EFNA5 0 0 154 153 1 1
    WDR41 ZBTB17 0 0 54 270 1 1
    WDR41 TKT 184 0 0 183 1 1
    WDR41 CHMP5 0 0 54 639 1 1
    WDR41 C9orf72 965 800 987 999 1 2
    WDR41 ZNF92 0 0 261 261 1 1
    WDR41 TFE3 0 0 150 304 1 1
    WDR41 PLEKHA4 270 0 0 270 1 1
    WDR41 RAB7A 0 0 323 353 1 2
    WDR41 TBC1D25 0 0 82 155 1 1
    WDR41 TAGLN3 0 0 150 283 1 1
    WDR41 TMEM55A 0 0 0 420 1 1
    WDR41 CDYL 0 0 143 274 1 1
    WDR41 KIF1B 0 0 160 189 1 1
    WDR41 WIPI2 0 0 184 256 1 2
    WDR41 LRRK2 270 0 84 328 1 2
    WDR41 ULK2 0 0 87 186 1 2
    WDR41 GPC5 0 0 97 162 1 1
    WDR41 FNIP2 0 0 391 390 1 1
    WDR41 TAPT1 0 0 310 383 1 1
    WDR41 ZNF292 0 0 177 177 1 1
    WDR41 TANK 0 0 175 175 1 1
    WDR41 DENND3 0 0 391 447 1 2
    WDR41 CHCHD10 0 0 107 150 1 1
    WDR41 SLC25A12 0 0 146 277 1 1
    WDR41 RRAGD 0 0 147 602 1 1
    WDR41 TBKBP1 0 0 154 318 1 1
    WDR41 GSAP 0 0 219 224 1 1
    WDR41 ENSG00000264668 0 0 146 161 1 1
    WDR41 RAB29 0 0 325 374 1 1
    WDR41 TRERF1 0 0 84 255 1 1
    WDR41 RFC3 0 0 127 171 1 1
    WDR41 ARNTL2 0 0 133 151 1 1
    WDR41 MOB3A 0 0 0 547 1 1
    WDR41 RASGRP3 0 360 0 361 1 1
    WDR41 ESYT1 0 0 157 165 1 1
    WDR41 CD300C 0 0 181 181 1 1
    WDR41 ZC3H12D 0 0 223 342 1 1
    WDR41 ATG2A 0 0 54 223 1 2
    WDR41 METTL21A 0 0 241 324 1 1
    WDR41 ADIRF 0 0 181 181 1 1
    WDR41 TFEB 0 0 370 474 1 2
    WDR41 ATG101 270 0 406 613 1 2
    WDR41 HSPB8 0 0 112 249 1 2
    WDR41 RAB8A 0 800 594 924 1 2
    WDR41 KIFC2 0 0 234 297 1 1
    WDR41 SYNM 0 0 141 160 1 1
    WDR41 TRANK1 0 0 204 325 1 1
    WDR41 SQSTM1 0 0 391 417 1 2
    WDR41 FLRT1 0 0 203 204 1 1
    WDR41 ACOT13 0 0 193 194 1 1
    WDR41 CLYBL 0 0 67 167 1 1
    WDR41 ZNF428 0 0 139 212 1 1
    WDR41 CNTN4 0 0 113 215 1 1
    WDR41 GPR6 0 0 168 167 1 1
    WDR41 STUB1 0 0 0 179 1 2
    WDR41 TNNT1 0 0 108 172 1 1
    WDR41 BRPF1 0 0 54 209 1 1
    WDR41 ATG13 0 0 395 483 1 2
    WDR41 ZW10 0 0 134 157 1 1
    WDR41 EXOC1 0 0 138 157 1 1
    WDR41 ATG12 0 0 91 150 1 2
    WDR41 WDR77 0 0 123 205 1 1
    WDR41 ATAD3C 0 0 0 183 1 1
    WDR41 CELF4 0 0 160 244 1 1
    WDR41 APBB2 292 0 0 292 1 1
    WDR41 PDE3B 0 720 0 723 1 1
    WDR41 TARDBP 0 0 293 294 1 1
    WDR41 GNG7 0 0 54 218 1 1
    WDR41 DENND1B 0 0 157 157 1 1
    WDR41 FAM208A 0 0 0 167 1 1
    WDR41 QPCT 0 0 144 167 1 1
    WDR41 MYOZ3 0 0 230 349 1 1
    WDR41 PSTPIP2 0 0 175 302 1 1
    WDR41 RMDN3 117 0 157 229 1 1
    WDR41 SMTNL2 0 0 241 357 1 1
    WDR41 RAB24 0 0 213 255 1 2
    WDR41 ATG9A 0 0 150 422 1 2
    WDR41 MOB3B 0 0 74 654 1 1
    WDR41 LAMP1 86 0 207 307 1 2
    WDR41 LAMTOR1 0 0 134 222 1 1
    WDR41 TOMM22 151 0 0 150 1 1
    WDR41 PRKDC 0 0 0 190 1 2
    WDR41 PFN3 0 0 107 162 1 1
    WDR41 HGNC:9979 0 0 234 234 1 1
    WDR41 RAB33A 0 0 294 338 1 1
    WDR41 RAB42 0 0 0 173 1 1
    WDR41 DBP 0 0 157 156 1 1
    WDR41 TMEM106B 0 0 149 180 1 1
    WDR41 RAB35 0 0 165 165 1 1
    WDR41 TIMM50 0 0 170 221 1 1
    WDR41 RAB1A 0 0 492 514 1 2
    WDR41 CPNE5 0 0 91 181 1 1
    WDR41 ZRSR2 0 0 108 195 1 1
    WDR41 IPMK 0 0 54 155 1 1
    WDR41 ENSG00000273637 0 0 0 642 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005096 Molecular Function GTPase activator activity enables IMP
    GO:0005085 Molecular Function guanyl-nucleotide exchange factor activity contributes_to IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0006914 Biological Process autophagy involved_in IEA
    GO:0045920 Biological Process negative regulation of exocytosis involved_in NAS
    GO:0050777 Biological Process negative regulation of immune response involved_in NAS
    GO:0010506 Biological Process regulation of autophagy involved_in IMP
    GO:0010506 Biological Process regulation of autophagy involved_in NAS
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005737 Cellular Component cytoplasm located_in NAS
    GO:0032045 Cellular Component guanyl-nucleotide exchange factor complex part_of IDA
    GO:0032045 Cellular Component guanyl-nucleotide exchange factor complex part_of IPI
    GO:0005765 Cellular Component lysosomal membrane located_in HDA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XM_011543505 3 mRNA transcript variant X1 NC_000005 Reference
    XM_047417350 1 mRNA transcript variant X4 NC_000005 Reference
    XM_047417349 1 mRNA transcript variant X3 NC_000005 Reference
    XM_005248551 5 mRNA transcript variant X5 NC_000005 Reference
    NM_018268 4 mRNA None NC_000005 Reference
    XM_017009606 2 mRNA transcript variant X2 NC_000005 Reference
    XM_011543507 3 mRNA transcript variant X8 NC_000005 Reference
    XM_005248552 4 mRNA transcript variant X7 NC_000005 Reference
    XM_047417351 1 mRNA transcript variant X6 NC_000005 Reference