PEX14

peroxisomal biogenesis factor 14
General Information
Name peroxisomal biogenesis factor 14
Alias
  • peroxisomal membrane protein PEX14
  • NF-E2 associated polypeptide 2
  • PTS1 receptor docking protein
  • peroxin-14
  • peroxisomal membrane anchor protein PEX14
  • peroxisomal membrane anchor protein Pex14p
Synonyms NAPP2 PBD13A Pex14p dJ734G22.2
Gene_family Peroxins
organism Homo sapiens
entrez_id 5195
location 1p36.22
transcript_count 10
exon_count 13
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]
      Stringdb Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins
      nextProt Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:9653144, PubMed:24235149, PubMed:28765278). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    PEX14 BioGRID PPIA GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PEX14 GeneID BioGRID Co-purification; Cross-Linking-MS (XL-MS); Reconstituted Complex; Two-hybrid
    PEX14 BioGRID Rab18 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CBFA2T2 GeneID BioGRID Protein-peptide
    PEX14 BioGRID KDM5D GeneID BioGRID Protein-peptide
    PEX14 BioGRID TONSL GeneID BioGRID Protein-peptide
    PEX14 BioGRID NFKBIL1 GeneID BioGRID Protein-peptide
    PEX14 BioGRID NEDD9 GeneID BioGRID Protein-peptide
    PEX14 BioGRID ACACB GeneID BioGRID Protein-peptide
    PEX14 BioGRID FSD1 GeneID BioGRID Protein-peptide
    PEX14 BioGRID AFTPH GeneID BioGRID Protein-peptide
    PEX14 BioGRID CAMTA1 GeneID BioGRID Protein-peptide
    PEX14 BioGRID DYRK1B GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID PRKAA2 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID HSPA1A GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID RANBP9 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID E2F4 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID ARL10 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CLNS1A GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID RBIS GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID ENY2 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID STK38L GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID EIF3G GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID UBA52 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    PEX14 BioGRID PRKCSH GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID PHYH GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID NEU2 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID MAGEA9 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID FOXJ1 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID FGF4 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID AP2M1 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID TP63 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID CCL4 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID CCL4L1 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID P4HA3 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID POLR3H GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID GPR156 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID CROCCP2 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID NAA40 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID IKZF5 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID TRAK1 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID HOMER3 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID PNPLA2 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID MIER2 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID CEP170B GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID STXBP4 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SPICE1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SPC24 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SMCR8 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PDZD8 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CNTROB GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SYAP1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ARHGAP18 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ACBD5 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID KNSTRN GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID NAV1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID KIAA1671 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID C1orf198 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID COG3 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CEP63 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID RUFY1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID IFT74 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CSTPP1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CENPH GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ACBD3 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID EXOC4 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CAMSAP3 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID MRTFA GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID MAVS GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PLEKHG1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID BIRC6 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID KIF15 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID MYO5C GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID N4BP2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SCYL2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID RUFY2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID MED29 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID VPS13D GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ALDH3A2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID RGPD6 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ATRIP GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    PEX14 BioGRID TEX9 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CEP55 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID IFT57 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID MTARC2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID OCIAD1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CC2D1A GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID NELFCD GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CCDC22 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ARFIP1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CACYBP GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID COG4 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID FKBP8 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID NUP62 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SCFD1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SYNE2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID UBXN4 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID KIF1B GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ERC1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID LIMCH1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CEP131 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ATF6 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID LMTK2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID TDRKH GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID AFG3L2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SUGT1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PEX19 GeneID BioGRID Affinity Capture-Luminescence; Co-fractionation; Co-purification; FRET; Proximity Label-MS; Reconstituted Complex; Two-hybrid
    PEX14 BioGRID PTPN1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PRKAR2B GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PRKAR2A GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PPP2R3A GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PEX6 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PEX1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PCNT GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID OCRL GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID NUP88 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID LPP GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID LMO7 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID INPPL1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID HSD17B4 GeneID BioGRID Co-purification; Proximity Label-MS
    PEX14 BioGRID HK1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID NR3C1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID GAK GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CDR2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ATP5F1B GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ENTR1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SPAG5 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID TACC2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID UNC13B GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PIBF1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID STUB1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID MPHOSPH9 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID DNM1L GeneID BioGRID Co-purification; Proximity Label-MS
    PEX14 BioGRID GCC2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID KIF20B GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID NUMBL GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ARHGEF2 GeneID BioGRID Co-purification; Proximity Label-MS
    PEX14 BioGRID RABEP1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID LIMD1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID TNKS GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID AGPS GeneID BioGRID Co-purification; Proximity Label-MS
    PEX14 BioGRID PEX3 GeneID BioGRID Co-purification; Proximity Label-MS
    PEX14 BioGRID OGT GeneID BioGRID Reconstituted Complex
    PEX14 BioGRID AKAP1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ZFPL1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID TTC1 GeneID BioGRID Co-purification; Proximity Label-MS
    PEX14 BioGRID TACC1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SNX2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ITSN1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID SCP2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID VPS52 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID RAB3B GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID PEX5 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Proximity Label-MS; Reconstituted Complex; Two-hybrid
    PEX14 BioGRID PXMP2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID ABCD3 GeneID BioGRID Co-purification; Proximity Label-MS
    PEX14 BioGRID LGALS9 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID Apc2 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID Rnf183 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID EXD2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID RMDN3 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID MARCHF5 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID MTCH1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID KIF14 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID Arhgap18 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID RHOT2 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CENPK GeneID BioGRID Two-hybrid
    PEX14 BioGRID COPS4 GeneID BioGRID Two-hybrid
    PEX14 BioGRID MARF1 GeneID BioGRID Two-hybrid
    PEX14 BioGRID GET3 GeneID BioGRID Two-hybrid
    PEX14 BioGRID SCARB2 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID PEX26 GeneID BioGRID FRET; Reconstituted Complex
    PEX14 BioGRID ACTC1 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID TOMM20 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID TOMM22 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID CAT GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID HNRNPL GeneID BioGRID Affinity Capture-RNA
    PEX14 BioGRID MTNR1A GeneID BioGRID Two-hybrid
    PEX14 BioGRID PNPLA3 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID SIRT6 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID CROCC GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID RPL28 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID NME3 GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID TUBB GeneID BioGRID Affinity Capture-MS; Co-fractionation; Co-purification
    PEX14 BioGRID NUP35 GeneID BioGRID Proximity Label-MS
    PEX14 BioGRID VAPA GeneID BioGRID Affinity Capture-MS
    PEX14 BioGRID ELAVL3 GeneID BioGRID Co-fractionation
    PEX14 BioGRID SLC27A2 GeneID BioGRID Co-fractionation
    PEX14 BioGRID TUBA4A GeneID BioGRID Co-purification
    PEX14 BioGRID TUBB2B GeneID BioGRID Co-purification
    PEX14 BioGRID TUBB8 GeneID BioGRID Co-purification
    PEX14 BioGRID ATAD1 GeneID BioGRID Co-purification
    PEX14 BioGRID TUBB6 GeneID BioGRID Co-purification
    PEX14 BioGRID FAR1 GeneID BioGRID Co-purification
    PEX14 BioGRID DYNC2H1 GeneID BioGRID Co-purification
    PEX14 BioGRID TUBG2 GeneID BioGRID Co-purification
    PEX14 BioGRID CNOT1 GeneID BioGRID Co-purification
    PEX14 BioGRID CCT5 GeneID BioGRID Co-purification
    PEX14 BioGRID DHRS4 GeneID BioGRID Co-purification
    PEX14 BioGRID IQGAP2 GeneID BioGRID Co-purification
    PEX14 BioGRID CCT8 GeneID BioGRID Co-purification
    PEX14 BioGRID CCT2 GeneID BioGRID Co-purification
    PEX14 BioGRID CCT4 GeneID BioGRID Co-purification
    PEX14 BioGRID CCT7 GeneID BioGRID Co-purification
    PEX14 BioGRID TUBB4B GeneID BioGRID Co-purification
    PEX14 BioGRID TUBB4A GeneID BioGRID Co-purification
    PEX14 BioGRID TUBB3 GeneID BioGRID Co-purification
    PEX14 BioGRID LRPPRC GeneID BioGRID Co-purification
    PEX14 BioGRID PEX16 GeneID BioGRID Co-purification
    PEX14 BioGRID IQGAP1 GeneID BioGRID Co-purification
    PEX14 BioGRID GNPAT GeneID BioGRID Co-purification
    PEX14 BioGRID TUBA1A GeneID BioGRID Co-purification
    PEX14 BioGRID TUBB2A GeneID BioGRID Co-purification
    PEX14 BioGRID CCT3 GeneID BioGRID Co-purification
    PEX14 BioGRID TCP1 GeneID BioGRID Co-purification
    PEX14 BioGRID PEX2 GeneID BioGRID Co-purification
    PEX14 BioGRID MAP2K2 GeneID BioGRID Co-purification
    PEX14 BioGRID PEX13 GeneID BioGRID Co-purification; Reconstituted Complex; Two-hybrid
    PEX14 BioGRID PEX12 GeneID BioGRID Co-purification
    PEX14 BioGRID PEX10 GeneID BioGRID Co-purification
    PEX14 BioGRID KIF11 GeneID BioGRID Co-purification
    PEX14 BioGRID IMPDH2 GeneID BioGRID Co-purification
    PEX14 BioGRID DNM2 GeneID BioGRID Co-purification
    PEX14 BioGRID DYNC1I2 GeneID BioGRID Co-purification
    PEX14 BioGRID DYNC1H1 GeneID BioGRID Co-purification
    PEX14 BioGRID DCTN1 GeneID BioGRID Co-purification
    PEX14 BioGRID CNP GeneID BioGRID Co-purification
    PEX14 BioGRID CCT6A GeneID BioGRID Co-purification
    PEX14 Protein ZHX1 GeneID HPRD None
    PEX14 Protein NFE2 GeneID HPRD None
    PEX14 Protein MED8 GeneID HPRD None
    PEX14 Protein PEX14 GeneID HPRD None
    PEX14 Protein PEX7 GeneID HPRD None
    PEX14 Protein SMARCC2 GeneID HPRD None
    PEX14 Protein HDAC1 GeneID HPRD None
    PEX14 Protein PEX5 GeneID HPRD None
    PEX14 Protein PEX19 GeneID HPRD None
    PEX14 BioGRID PEX7 GeneID BioGRID Reconstituted Complex
    PEX14 BioGRID MED8 GeneID BioGRID Two-hybrid
    PEX14 BioGRID ZHX1 GeneID BioGRID Two-hybrid
    PEX14 BioGRID SMARCC2 GeneID BioGRID Two-hybrid
    PEX14 Protein PEX5 GeneID BIND PEX14 interacts with PEX5.
    PEX14 Protein PEX14 GeneID BIND PEX14 interacts with itself to form a dimer.
    PEX14 Protein PEX19 GeneID BIND PEX14 interacts with PEX19.
    PEX14 Protein PEX13 GeneID BIND PEX14 interacts with PEX13.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    PEX14 ECHDC1 0 0 0 237 1 1
    PEX14 ACOT8 0 600 116 633 1 1
    PEX14 HPCA 0 0 0 151 1 1
    PEX14 MAP2K2 270 0 0 270 1 1
    PEX14 TUBA1A 270 0 0 303 1 1
    PEX14 HSD17B4 270 600 155 788 1 1
    PEX14 TECPR1 0 0 0 260 1 2
    PEX14 ETV2 0 0 115 405 1 1
    PEX14 CAT 114 600 459 893 1 1
    PEX14 UBB 0 600 0 628 1 1
    PEX14 IDE 0 600 91 626 1 1
    PEX14 PTOV1 0 0 236 692 1 1
    PEX14 CENPK 240 0 0 239 1 1
    PEX14 INF2 0 0 0 158 1 1
    PEX14 HTD2 0 0 0 236 1 1
    PEX14 FAF2 0 0 139 178 1 1
    PEX14 ACAT1 0 0 0 197 1 1
    PEX14 FH 0 0 228 228 1 1
    PEX14 SMG7 0 0 0 172 1 1
    PEX14 HIST1H3F 0 0 0 167 1 1
    PEX14 CCT6A 270 0 0 273 1 1
    PEX14 KIF14 270 0 0 307 1 1
    PEX14 ILVBL 0 0 0 353 1 1
    PEX14 PEX26 651 600 889 983 1 1
    PEX14 AGXT 0 600 170 677 1 1
    PEX14 NOS3 0 0 0 159 1 1
    PEX14 ATP6V1F 0 0 155 162 1 1
    PEX14 FNBP1L 0 0 46 210 1 1
    PEX14 IQGAP2 270 0 0 307 1 1
    PEX14 KIFC3 0 0 180 539 1 1
    PEX14 PEX10 270 600 755 980 1 1
    PEX14 DHRS1 0 0 0 178 1 1
    PEX14 TCP1 270 0 0 273 1 1
    PEX14 HIST1H3H 0 0 0 167 1 1
    PEX14 PDZD7 0 0 169 169 1 1
    PEX14 UVRAG 0 0 45 181 1 2
    PEX14 CCT2 270 0 0 276 1 1
    PEX14 ENSG00000132716 0 0 0 606 1 1
    PEX14 SCP2 161 600 216 965 1 1
    PEX14 RNF185 0 0 0 404 1 1
    PEX14 VAPB 0 0 193 462 1 1
    PEX14 SLC25A21 0 0 0 229 1 1
    PEX14 TRAP1 161 0 0 161 1 2
    PEX14 ECHDC2 0 0 0 237 1 1
    PEX14 TECPR2 0 0 0 190 1 2
    PEX14 MARC2 0 0 234 253 1 1
    PEX14 NBR1 0 0 230 266 1 2
    PEX14 TUBB4B 270 0 0 359 1 1
    PEX14 MLYCD 0 600 0 652 1 1
    PEX14 ACADM 0 0 0 205 1 1
    PEX14 FIS1 0 900 332 948 1 2
    PEX14 ACOX2 0 600 83 807 1 1
    PEX14 ACOXL 0 0 0 225 1 1
    PEX14 TYSND1 0 600 463 861 1 1
    PEX14 NDUFAF3 0 0 0 559 1 1
    PEX14 AP2M1 228 0 0 231 1 1
    PEX14 ECHS1 0 0 0 237 1 1
    PEX14 ARF4 0 0 103 159 1 1
    PEX14 SPATA5L1 0 0 0 252 1 1
    PEX14 EIF2B2 0 0 0 281 1 1
    PEX14 SPATA5 0 0 0 247 1 1
    PEX14 SKI 0 0 216 216 1 1
    PEX14 PEX6 0 600 734 974 1 1
    PEX14 SDR16C5 0 0 74 168 1 1
    PEX14 PHGDH 0 0 72 166 1 1
    PEX14 NVL 0 0 0 266 1 1
    PEX14 DHRS2 0 0 0 173 1 1
    PEX14 HIBCH 0 0 0 237 1 1
    PEX14 CDYL2 0 0 0 455 1 1
    PEX14 HMGA2 0 0 0 181 1 1
    PEX14 UBE2E2 0 0 0 238 1 1
    PEX14 HIST1H3G 0 0 0 167 1 1
    PEX14 ITM2B 0 0 124 247 1 1
    PEX14 HAO1 0 600 0 600 1 1
    PEX14 CRAT 0 600 47 747 1 1
    PEX14 ABCD2 0 900 216 938 1 1
    PEX14 PEX2 270 600 729 985 1 1
    PEX14 WARS2 0 0 0 428 1 1
    PEX14 EEA1 0 0 109 185 1 1
    PEX14 CCT3 270 0 0 273 1 1
    PEX14 ENSG00000268083 0 0 0 324 1 1
    PEX14 TTC1 270 0 53 330 1 1
    PEX14 BIRC6 0 0 0 218 1 1
    PEX14 TUBB8 270 0 0 376 1 1
    PEX14 ZFAND6 0 600 231 679 1 1
    PEX14 COQ6 0 0 0 250 1 1
    PEX14 PSMB5 0 0 0 189 1 1
    PEX14 ECH1 0 600 0 751 1 1
    PEX14 DAO 0 600 45 643 1 1
    PEX14 ENSG00000268465 0 0 61 204 1 1
    PEX14 IDI1 0 0 134 188 1 1
    PEX14 TOMM20 240 0 320 708 1 1
    PEX14 STX17 0 0 0 313 1 2
    PEX14 OXR1 0 0 47 197 1 1
    PEX14 POP4 0 0 0 279 1 1
    PEX14 TUBB2A 270 0 0 345 1 1
    PEX14 ENSG00000279928 0 0 0 211 1 1
    PEX14 ABCD3 270 900 654 976 1 1
    PEX14 ECI2 0 600 0 900 1 1
    PEX14 STX16 0 0 113 319 1 1
    PEX14 POT1 0 0 203 294 1 1
    PEX14 DBI 0 0 73 326 1 1
    PEX14 LNX1 0 0 108 201 1 1
    PEX14 ATG101 0 0 54 174 1 2
    PEX14 HNRNPL 270 0 0 282 1 1
    PEX14 TEX9 0 0 0 155 1 1
    PEX14 TUBB2B 270 0 0 345 1 1
    PEX14 TUBB6 270 0 0 298 1 1
    PEX14 MASP2 0 0 103 159 1 1
    PEX14 HIST3H3 0 0 0 167 1 1
    PEX14 ZNF24 0 0 171 604 1 1
    PEX14 ABCD4 0 0 57 202 1 1
    PEX14 ZADH2 0 0 96 434 1 1
    PEX14 COPS4 272 0 0 294 1 1
    PEX14 HDAC1 213 0 471 568 1 2
    PEX14 TOMM22 254 0 0 254 1 1
    PEX14 EIF3A 0 0 0 210 1 1
    PEX14 PTGR2 0 0 0 244 1 1
    PEX14 RPS27A 0 600 0 610 1 1
    PEX14 HIST1H3I 0 0 0 167 1 1
    PEX14 PNPLA3 450 0 0 470 1 1
    PEX14 IQCA1 0 0 0 247 1 1
    PEX14 SCLY 0 0 0 210 1 1
    PEX14 SCP2D1 0 0 0 439 1 1
    PEX14 LNX2 0 0 170 391 1 1
    PEX14 PICALM 0 0 0 190 1 1
    PEX14 HIST1H3J 0 0 0 167 1 1
    PEX14 RABAC1 0 0 0 309 1 1
    PEX14 HIST1H3E 0 0 0 167 1 1
    PEX14 DNM1 0 0 234 305 1 1
    PEX14 HSPA5 0 0 67 178 1 2
    PEX14 SMIM12 0 0 406 764 1 1
    PEX14 RPS15A 0 0 0 156 1 1
    PEX14 ACADSB 0 0 0 223 1 1
    PEX14 ALG10 0 0 73 215 1 1
    PEX14 ACAT2 0 0 0 197 1 1
    PEX14 CCT7 270 0 0 274 1 1
    PEX14 ZGPAT 0 0 0 320 1 1
    PEX14 CBR4 0 0 0 151 1 1
    PEX14 LHX4-AS1 0 0 0 318 1 1
    PEX14 CNP 270 0 0 270 1 1
    PEX14 SEC62 0 0 153 493 1 1
    PEX14 AMACR 0 600 0 649 1 1
    PEX14 TUBG2 270 0 0 298 1 1
    PEX14 ACADVL 0 0 0 205 1 1
    PEX14 UBE2E3 0 0 0 234 1 1
    PEX14 ACOX3 0 600 396 796 1 1
    PEX14 NUDT19 0 600 103 625 1 1
    PEX14 PRKCSH 194 0 0 194 1 1
    PEX14 PEX16 270 900 764 986 1 1
    PEX14 NCALD 0 0 0 151 1 1
    PEX14 PHB 0 0 66 155 1 1
    PEX14 PEX3 270 600 764 971 1 2
    PEX14 ACADL 0 0 0 205 1 1
    PEX14 HSD17B14 0 0 0 173 1 1
    PEX14 AUH 0 0 0 237 1 1
    PEX14 TRIP10 0 0 0 164 1 1
    PEX14 ATAD1 270 900 194 951 1 1
    PEX14 UBE2D2 0 600 166 722 1 1
    PEX14 IQCA1P1 0 0 0 247 1 1
    PEX14 TUBB 410 0 0 476 1 1
    PEX14 ECI1 0 0 107 307 1 1
    PEX14 ENSG00000100926 0 0 284 313 1 1
    PEX14 ABCD1 0 900 500 960 1 1
    PEX14 ACADS 0 0 0 223 1 1
    PEX14 ACOX1 160 600 288 885 1 1
    PEX14 EPHX1 0 0 0 168 1 1
    PEX14 PECR 0 600 0 662 1 1
    PEX14 CYTH1 0 0 0 252 1 1
    PEX14 HIST2H3A 0 0 0 167 1 1
    PEX14 PXMP2 0 900 0 904 1 1
    PEX14 DYNC1H1 270 0 0 270 1 1
    PEX14 POLE3 0 0 0 367 1 1
    PEX14 LRPPRC 270 0 0 270 1 1
    PEX14 SMG6 0 0 0 162 1 1
    PEX14 UBC 0 600 0 628 1 1
    PEX14 SNAP91 0 0 0 190 1 1
    PEX14 HADHB 0 0 0 197 1 1
    PEX14 IVD 0 0 0 205 1 1
    PEX14 CORT 0 0 190 216 1 1
    PEX14 USP30 0 0 203 213 1 1
    PEX14 DYNLL2 0 0 0 343 1 1
    PEX14 DDX11 0 0 0 211 1 1
    PEX14 GPX1 0 0 139 192 1 1
    PEX14 DHRS4L2 0 0 0 337 1 1
    PEX14 STX7 0 0 0 290 1 2
    PEX14 ULK1 0 0 108 163 1 2
    PEX14 CYTH2 0 0 51 196 1 1
    PEX14 DNAL4 0 0 0 317 1 1
    PEX14 SSX2IP 0 0 150 611 1 1
    PEX14 STX12 0 0 151 466 1 1
    PEX14 MTRR 0 0 0 160 1 1
    PEX14 CTSD 0 0 95 263 1 2
    PEX14 PTGR1 0 0 0 244 1 1
    PEX14 MPV17 0 600 0 605 1 1
    PEX14 FMN1 0 0 0 206 1 1
    PEX14 NUDT7 0 600 0 600 1 1
    PEX14 AGPS 270 600 366 844 1 1
    PEX14 DNM1L 270 0 281 526 1 2
    PEX14 DECR2 0 600 66 681 1 1
    PEX14 GABARAP 0 0 142 166 1 2
    PEX14 HIST1H3A 0 0 0 167 1 1
    PEX14 SNTG1 0 0 66 160 1 1
    PEX14 SLC27A2 270 600 0 702 1 1
    PEX14 ACBD4 0 0 94 342 1 1
    PEX14 UBA52 0 600 0 600 1 1
    PEX14 AKR7A2 0 0 158 671 1 1
    PEX14 RHOT2 117 0 162 417 1 1
    PEX14 HFE 0 0 0 161 1 1
    PEX14 HIST1H3B 0 0 0 167 1 1
    PEX14 HIST1H3C 0 0 0 167 1 1
    PEX14 ATAD2B 0 0 0 271 1 1
    PEX14 CLYBL 0 0 217 217 1 1
    PEX14 GSTK1 0 600 46 602 1 1
    PEX14 FAM175B 0 0 193 193 1 1
    PEX14 PRKAR2A 0 0 141 176 1 1
    PEX14 DYNLL1 0 0 0 343 1 1
    PEX14 CENPA 0 0 0 161 1 1
    PEX14 XRCC6 0 0 0 198 1 1
    PEX14 IMPDH2 270 0 0 270 1 1
    PEX14 UBE2T 0 0 0 234 1 1
    PEX14 VDAC2 0 0 84 248 1 1
    PEX14 CPT2 0 0 0 404 1 1
    PEX14 YIF1A 0 0 81 204 1 1
    PEX14 TUBA4A 270 0 0 303 1 1
    PEX14 CD2BP2 0 0 113 465 1 1
    PEX14 ACBD5 0 900 420 979 1 1
    PEX14 DECR1 0 0 0 192 1 1
    PEX14 RPL28 186 0 0 186 1 1
    PEX14 TRAK2 0 0 233 631 1 1
    PEX14 KIFC1 0 0 0 205 1 1
    PEX14 SRGAP2 0 0 0 161 1 1
    PEX14 KIAA0430 235 0 0 235 1 1
    PEX14 GCDH 0 0 0 205 1 1
    PEX14 ACAD9 0 0 0 205 1 1
    PEX14 GDAP1 0 900 74 913 1 1
    PEX14 CDC5L 77 0 0 215 1 1
    PEX14 RB1CC1 0 0 126 163 1 2
    PEX14 MFF 0 0 341 547 1 1
    PEX14 POR 0 0 201 505 1 1
    PEX14 PEX1 270 600 729 966 1 1
    PEX14 DYNC1I2 270 0 0 326 1 1
    PEX14 ASNA1 118 0 218 347 1 1
    PEX14 TM9SF1 0 0 283 312 1 2
    PEX14 UBE2D1 0 600 52 689 1 1
    PEX14 STOML1 0 0 74 481 1 1
    PEX14 KCNC2 0 0 47 195 1 1
    PEX14 VAPA 151 0 74 506 1 1
    PEX14 CDYL 0 0 0 459 1 1
    PEX14 TSNARE1 0 0 0 290 1 1
    PEX14 DHRS4 270 600 0 789 1 1
    PEX14 RAB33B 0 0 53 260 1 2
    PEX14 TUBB4A 270 0 0 345 1 1
    PEX14 CNOT1 270 0 0 284 1 1
    PEX14 BFSP2 0 0 156 155 1 1
    PEX14 PHYH 0 600 325 778 1 1
    PEX14 ELOVL5 0 0 81 177 1 1
    PEX14 CHD7 0 0 135 180 1 1
    PEX14 PDE8A 0 0 156 155 1 1
    PEX14 AKR7A3 0 0 0 398 1 1
    PEX14 NOS2 0 600 0 649 1 1
    PEX14 TRAK1 0 0 142 334 1 1
    PEX14 FKBP8 117 0 0 173 1 1
    PEX14 DDO 0 600 0 617 1 1
    PEX14 PSMB1 0 0 0 632 1 1
    PEX14 UBE2D3 0 600 127 709 1 1
    PEX14 NFE2 213 0 614 683 1 1
    PEX14 SRM 0 0 144 171 1 1
    PEX14 USP9X 0 0 74 164 1 1
    PEX14 NSF 0 0 0 247 1 1
    PEX14 ACOT4 0 600 0 605 1 1
    PEX14 RPS3 0 0 83 224 1 1
    PEX14 IQGAP1 270 0 0 294 1 1
    PEX14 NCS1 0 0 0 151 1 1
    PEX14 PRDX5 0 0 90 186 1 1
    PEX14 GRID2IP 0 0 0 153 1 1
    PEX14 FIGNL1 0 0 0 247 1 1
    PEX14 SEC61A1 0 0 149 184 1 1
    PEX14 PEX19 974 600 923 999 1 1
    PEX14 ACOT2 0 600 0 605 1 1
    PEX14 PIPOX 0 600 70 652 1 1
    PEX14 ENSG00000273154 0 0 0 302 1 1
    PEX14 EPHX2 0 600 0 626 1 1
    PEX14 PIK3C3 0 0 59 302 1 2
    PEX14 CROT 0 600 0 600 1 1
    PEX14 H3F3A 0 0 0 170 1 1
    PEX14 ELAVL3 272 0 0 272 1 1
    PEX14 COG4 0 0 0 260 1 1
    PEX14 CCT5 270 0 0 275 1 1
    PEX14 PEX11A 0 0 681 872 1 1
    PEX14 MAP1LC3A 0 0 43 216 1 2
    PEX14 PEX13 677 800 987 999 1 1
    PEX14 PACS2 0 0 127 150 1 1
    PEX14 BAAT 0 600 172 654 1 1
    PEX14 UBE2E1 0 0 0 234 1 1
    PEX14 SLC50A1 0 0 0 284 1 1
    PEX14 FAR1 270 0 181 415 1 1
    PEX14 BRCC3 0 0 150 169 1 1
    PEX14 KIFC2 0 0 0 164 1 1
    PEX14 RNF5 0 0 0 404 1 1
    PEX14 HADHA 0 0 0 237 1 1
    PEX14 PNPLA2 130 0 0 183 1 1
    PEX14 EIF2B1 0 0 0 181 1 1
    PEX14 ACAA2 0 0 45 201 1 1
    PEX14 ACAD8 0 0 0 205 1 1
    PEX14 TOMM20L 0 0 0 461 1 1
    PEX14 EHHADH 0 600 0 688 1 1
    PEX14 CCT4 270 0 0 275 1 1
    PEX14 NFS1 0 0 0 297 1 1
    PEX14 TMEM135 0 0 208 208 1 1
    PEX14 TUBA1B 270 0 0 308 1 1
    PEX14 PEX7 270 600 919 998 1 1
    PEX14 ATG9A 0 0 140 180 1 2
    PEX14 HIST1H3D 0 0 0 167 1 1
    PEX14 MOCS2 0 0 518 518 1 1
    PEX14 UBE2N 0 0 0 240 1 1
    PEX14 DEPDC5 0 0 0 155 1 1
    PEX14 ARHGEF2 270 0 0 273 1 1
    PEX14 PSMB8 0 0 0 189 1 1
    PEX14 ZBTB17 0 0 144 354 1 1
    PEX14 HIST2H3C 0 0 0 167 1 1
    PEX14 VCP 0 0 97 300 1 2
    PEX14 FAM83B 0 0 209 220 1 1
    PEX14 H3F3C 0 0 0 167 1 1
    PEX14 PAOX 0 600 184 667 1 1
    PEX14 ENSG00000260300 0 0 0 161 1 1
    PEX14 KIF11 270 0 0 491 1 1
    PEX14 LONP2 160 600 294 790 1 1
    PEX14 RHOT1 0 0 170 258 1 1
    PEX14 CCT8 270 0 0 276 1 1
    PEX14 NOS1 0 0 0 159 1 1
    PEX14 HPCAL1 0 0 0 151 1 1
    PEX14 ACBD7 0 0 0 303 1 1
    PEX14 ALG10B 0 0 70 212 1 1
    PEX14 HAO2 0 600 0 600 1 1
    PEX14 SQLE 0 0 102 152 1 1
    PEX14 FNBP1 0 0 46 268 1 1
    PEX14 NDUFB9 0 0 123 215 1 1
    PEX14 SLC25A17 0 900 849 984 1 1
    PEX14 PEX11G 0 0 261 704 1 1
    PEX14 FIGN 0 0 0 247 1 1
    PEX14 TRIP13 0 0 0 247 1 1
    PEX14 ACSF3 0 0 0 426 1 1
    PEX14 PXMP4 0 900 75 905 1 1
    PEX14 HMGCL 0 600 0 607 1 1
    PEX14 RPAP2 0 0 0 250 1 1
    PEX14 PPARA 0 0 195 195 1 1
    PEX14 PEX11B 0 900 406 977 1 1
    PEX14 ATP6V1D 0 0 151 165 1 1
    PEX14 CHAT 0 0 0 369 1 1
    PEX14 GNPAT 270 600 294 789 1 1
    PEX14 HIST2H3PS2 0 0 0 167 1 1
    PEX14 HSDL2 0 0 0 609 1 1
    PEX14 DDRGK1 0 0 0 483 1 1
    PEX14 DYNC2H1 270 0 0 270 1 1
    PEX14 MIER2 209 0 0 226 1 1
    PEX14 PEX5 977 800 989 999 1 1
    PEX14 TCP11L1 270 0 0 270 1 1
    PEX14 MAGIX 0 0 465 610 1 1
    PEX14 SIRT6 130 0 0 174 1 1
    PEX14 SMG5 0 0 0 175 1 1
    PEX14 ALDH3A2 0 900 0 900 1 1
    PEX14 UBE2D4 0 0 0 234 1 1
    PEX14 IDH1 0 600 0 625 1 1
    PEX14 FNDC5 0 0 0 461 1 1
    PEX14 COPS3 0 0 0 284 1 1
    PEX14 EIF2B4 0 0 0 183 1 1
    PEX14 H3F3B 0 0 0 167 1 1
    PEX14 HACL1 0 600 0 755 1 1
    PEX14 CPTP 0 0 174 242 1 1
    PEX14 BDH2 0 0 0 173 1 1
    PEX14 DCTN1 270 0 0 270 1 1
    PEX14 SPAST 0 0 66 279 1 1
    PEX14 PEX5L 0 800 634 991 1 1
    PEX14 ACAA1 0 600 173 848 1 1
    PEX14 MAGI3 0 0 120 258 1 1
    PEX14 DNM2 270 0 468 636 1 1
    PEX14 HIST2H3D 0 0 0 167 1 1
    PEX14 NEU2 272 0 0 272 1 1
    PEX14 TUBB3 270 0 0 346 1 1
    PEX14 PEX12 270 600 898 993 1 1
    PEX14 SEC63 0 0 142 376 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0048487 Molecular Function beta-tubulin binding enables IPI
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0008017 Molecular Function microtubule binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0008320 Molecular Function protein transmembrane transporter activity enables IDA
    GO:0030674 Molecular Function protein-macromolecule adaptor activity enables IDA
    GO:0005102 Molecular Function signaling receptor binding enables IBA
    GO:0005102 Molecular Function signaling receptor binding enables IPI
    GO:0003714 Molecular Function transcription corepressor activity enables IDA
    GO:0034614 Biological Process cellular response to reactive oxygen species involved_in IDA
    GO:0034453 Biological Process microtubule anchoring involved_in IDA
    GO:0043433 Biological Process negative regulation of DNA-binding transcription factor activity involved_in IDA
    GO:0045892 Biological Process negative regulation of DNA-templated transcription involved_in IDA
    GO:0032091 Biological Process negative regulation of protein binding involved_in IDA
    GO:0007031 Biological Process peroxisome organization NOT involved_in IGI
    GO:0007031 Biological Process peroxisome organization involved_in ISS
    GO:0036250 Biological Process peroxisome transport along microtubule involved_in IDA
    GO:0016558 Biological Process protein import into peroxisome matrix involved_in IMP
    GO:0016560 Biological Process protein import into peroxisome matrix, docking involved_in IBA
    GO:0016560 Biological Process protein import into peroxisome matrix, docking involved_in IDA
    GO:0044721 Biological Process protein import into peroxisome matrix, substrate release involved_in IDA
    GO:0016561 Biological Process protein import into peroxisome matrix, translocation involved_in IDA
    GO:0065003 Biological Process protein-containing complex assembly involved_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0001650 Cellular Component fibrillar center located_in IDA
    GO:0016020 Cellular Component membrane located_in HDA
    GO:0016020 Cellular Component membrane located_in ISS
    GO:0005634 Cellular Component nucleus located_in NAS
    GO:1990429 Cellular Component peroxisomal importomer complex part_of IBA
    GO:0005778 Cellular Component peroxisomal membrane located_in HDA
    GO:0005778 Cellular Component peroxisomal membrane is_active_in IBA
    GO:0005778 Cellular Component peroxisomal membrane is_active_in IDA
    GO:0005778 Cellular Component peroxisomal membrane located_in IDA
    GO:0005778 Cellular Component peroxisomal membrane located_in ISS
    GO:0005778 Cellular Component peroxisomal membrane located_in TAS
    GO:0005777 Cellular Component peroxisome located_in IDA
    GO:0032991 Cellular Component protein-containing complex part_of IDA
    GO:0032991 Cellular Component protein-containing complex part_of ISS
    Pathways
    Name DB ID
    Metabolism of proteins Reactome R-HSA-392499
    Post-translational protein modification Reactome R-HSA-597592
    Protein ubiquitination Reactome R-HSA-8852135
    E3 ubiquitin ligases ubiquitinate target proteins Reactome R-HSA-8866654
    Peroxisomal protein import Reactome R-HSA-9033241
    Class I peroxisomal membrane protein import Reactome R-HSA-9603798
    Protein localization Reactome R-HSA-9609507
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XM_047422544 1 mRNA transcript variant X7 NC_000001 Reference
    XM_047422546 1 mRNA transcript variant X9 NC_000001 Reference
    XM_047422545 1 mRNA transcript variant X8 NC_000001 Reference
    XM_047422543 1 mRNA transcript variant X4 NC_000001 Reference
    NM_004565 3 mRNA None NC_000001 Reference
    XM_011541580 2 mRNA transcript variant X6 NC_000001 Reference
    XM_011541579 4 mRNA transcript variant X5 NC_000001 Reference
    XM_011541577 3 mRNA transcript variant X1 NC_000001 Reference
    XM_047422542 1 mRNA transcript variant X2 NC_000001 Reference
    XM_011541578 3 mRNA transcript variant X3 NC_000001 Reference