SH3GLB1

SH3 domain containing GRB2 like, endophilin B1
General Information
Name SH3 domain containing GRB2 like, endophilin B1
Alias
  • endophilin-B1
  • Bax-interacting factor 1
  • SH3 domain-containing GRB2-like protein B1
  • SH3-containing protein SH3GLB1
  • SH3-domain GRB2 like endophilin B1
  • protein phosphatase 1, regulatory subunit 70
  • testicular tissue protein Li 172
Synonyms CGI-61 KIAA0491 Bif-1 PPP1R70 dJ612B15.2
Gene_family N-BAR domain containing|Protein phosphatase 1 regulatory subunits
organism Homo sapiens
entrez_id 51100
location 1p22.3
transcript_count 9
exon_count 12
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
      Stringdb Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by a [...]
      nextProt Acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    SH3GLB1 BioGRID TRMT1 GeneID BioGRID Cross-Linking-MS (XL-MS)
    SH3GLB1 BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID GAPDH GeneID BioGRID Cross-Linking-MS (XL-MS)
    SH3GLB1 BioGRID PGK1 GeneID BioGRID Cross-Linking-MS (XL-MS)
    SH3GLB1 BioGRID STK38 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID CCNF GeneID BioGRID Proximity Label-MS
    SH3GLB1 BioGRID RPS6KL1 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID IRAK2 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID BAP1 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID SH3GLB2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Two-hybrid
    SH3GLB1 BioGRID FCGRT GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID WIF1 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID ATP9A GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID SERPINB3 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID LAMTOR1 GeneID BioGRID Proximity Label-MS
    SH3GLB1 BioGRID NDC80 GeneID BioGRID Proximity Label-MS
    SH3GLB1 BioGRID F8A1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID TTN GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID RABGGTB GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID GSTP1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID FN1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID HSCB GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID UBL7 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID SH3GLB1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID ITGB1BP2 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID KIF14 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID TAX1BP1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID SIN3A GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID TFIP11 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID ARFIP2 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID CACFD1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID FAM114A2 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID RABAC1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID HTATIP2 GeneID BioGRID Affinity Capture-Western; PCA; Reconstituted Complex; Two-hybrid
    SH3GLB1 BioGRID C1D GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID SYNGR3 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID SNX4 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID TPD52L2 GeneID BioGRID Co-fractionation; Two-hybrid
    SH3GLB1 BioGRID TPD52 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID SYP GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID SNX1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID SMIM5 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID RHEX GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID IRGM GeneID BioGRID Affinity Capture-Western; Two-hybrid
    SH3GLB1 BioGRID CMTM5 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID MAL2 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID ZNF576 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID RIC8A GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID AGTRAP GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID COQ8A GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID ABHD5 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID DESI2 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID CDKN2D GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID EXOSC5 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID POP6 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID TAE1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID PRCC GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID DRG1 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID CDK5 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID SEPTIN7 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID SARNP GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID SEPTIN11 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID SCYL2 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID CHORDC1 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID GORASP2 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID DIS3 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID COPZ1 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID SUB1 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID SERPINB13 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID CDH1 GeneID BioGRID Proximity Label-MS
    SH3GLB1 BioGRID RAB5A GeneID BioGRID Affinity Capture-Western
    SH3GLB1 BioGRID ACSL4 GeneID BioGRID Affinity Capture-Western
    SH3GLB1 BioGRID Csk GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID CEP128 GeneID BioGRID Proximity Label-MS
    SH3GLB1 BioGRID CDK2AP1 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID USP14 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID WARS1 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID UBE2I GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID FLAD1 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID RPRD1A GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID CCDC22 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID COMMD3 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID XPO7 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID VPS26C GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID FUNDC1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID PSMA1 GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID AARSD1 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID P3H1 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID NIF3L1 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID THG1L GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID NSUN2 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID LAP3 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID TPRKB GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID KIFBP GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID HSPBP1 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID ARPC1A GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID ARPC2 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID ACTR2 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID ACTR3 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID ARPC4 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID SH3GL1 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID RPA2 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID RANGAP1 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID PRKACA GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID PPP2R5D GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID LPP GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID AGFG1 GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID CALU GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID CALR GeneID BioGRID Co-fractionation
    SH3GLB1 BioGRID GADD45G GeneID BioGRID Two-hybrid
    SH3GLB1 BioGRID GADD45A GeneID BioGRID Affinity Capture-Western; Two-hybrid
    SH3GLB1 BioGRID APP GeneID BioGRID Reconstituted Complex
    SH3GLB1 BioGRID ADAM15 GeneID BioGRID Reconstituted Complex
    SH3GLB1 BioGRID ITCH GeneID BioGRID Affinity Capture-Western
    SH3GLB1 BioGRID KLHDC10 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID CUL2 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 BioGRID USP7 GeneID BioGRID Affinity Capture-MS
    SH3GLB1 Protein SH3GLB2 GeneID HPRD None
    SH3GLB1 Protein SH3GLB1 GeneID HPRD None
    SH3GLB1 Protein SYNJ1 GeneID HPRD None
    SH3GLB1 Protein MTA1 GeneID HPRD None
    SH3GLB1 Protein ADAM9 GeneID HPRD None
    SH3GLB1 Protein DNM2 GeneID HPRD None
    SH3GLB1 Protein BIN1 GeneID HPRD None
    SH3GLB1 Protein AMPH GeneID HPRD None
    SH3GLB1 Protein BAX GeneID HPRD None
    SH3GLB1 Protein HTT GeneID HPRD None
    SH3GLB1 BioGRID Map4k3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    SH3GLB1 BioGRID ARHGAP17 GeneID BioGRID Reconstituted Complex
    SH3GLB1 BioGRID SH3KBP1 GeneID BioGRID Reconstituted Complex
    SH3GLB1 BioGRID BAX GeneID BioGRID Affinity Capture-Western; Two-hybrid
    SH3GLB1 Protein SH3GLB2 GeneID BIND SH3GLB1 interacts with SH3GLB2.
    SH3GLB1 Protein SH3GLB1 GeneID BIND SH3GLB1 forms a homodimer.
    SH3GLB1 Protein BAX GeneID BIND An unspecified isoform of Bax interacts with SH3GLB1.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    SH3GLB1 ARFGEF1 0 0 0 274 1 1
    SH3GLB1 RRP8 0 0 125 358 1 1
    SH3GLB1 FNDC1 0 0 0 159 1 1
    SH3GLB1 DNM2 213 0 325 540 1 1
    SH3GLB1 SNX30 0 0 285 284 1 1
    SH3GLB1 ATG7 0 0 504 511 1 2
    SH3GLB1 MAP1B 0 0 143 211 1 1
    SH3GLB1 MAP1LC3C 0 0 265 284 1 2
    SH3GLB1 FAM45A 0 0 261 565 1 1
    SH3GLB1 SNX17 0 0 74 339 1 1
    SH3GLB1 ZNF205 0 0 218 390 1 1
    SH3GLB1 CDK2AP1 159 0 0 158 1 1
    SH3GLB1 BCL7B 0 0 128 160 1 1
    SH3GLB1 OPHN1 0 0 608 608 1 1
    SH3GLB1 MIEF2 62 0 266 341 1 1
    SH3GLB1 CCDC93 0 0 246 714 1 1
    SH3GLB1 FAM92B 0 0 181 181 1 1
    SH3GLB1 VPS35 0 0 95 188 1 1
    SH3GLB1 SUPT20H 0 0 119 358 1 1
    SH3GLB1 AMPH 213 0 517 656 1 1
    SH3GLB1 TRIM63 0 0 442 442 1 1
    SH3GLB1 BLMH 0 0 0 234 1 1
    SH3GLB1 BCAP29 0 0 113 225 1 1
    SH3GLB1 NRAP 0 0 0 194 1 1
    SH3GLB1 COMMD6 0 0 96 189 1 1
    SH3GLB1 ROCK1 0 0 398 398 1 1
    SH3GLB1 SH3GL1 245 0 370 393 1 1
    SH3GLB1 SERPINB1 0 0 57 253 1 1
    SH3GLB1 ARPC1A 245 0 0 244 1 1
    SH3GLB1 AMBRA1 0 0 737 742 1 2
    SH3GLB1 PPP1R9A 0 0 90 184 1 1
    SH3GLB1 SARNP 256 0 0 256 1 1
    SH3GLB1 GOPC 0 0 171 176 1 2
    SH3GLB1 AP2A1 0 0 95 190 1 1
    SH3GLB1 CALU 180 0 0 256 1 1
    SH3GLB1 ARHGAP17 270 0 120 344 1 1
    SH3GLB1 CDK5 265 0 439 620 1 2
    SH3GLB1 LZTFL1 0 0 0 243 1 1
    SH3GLB1 PRTG 0 0 0 159 1 1
    SH3GLB1 RPUSD2 0 0 0 223 1 1
    SH3GLB1 SH3BP1 0 0 242 258 1 1
    SH3GLB1 PTEN 0 0 234 253 1 2
    SH3GLB1 COMMD1 0 0 95 491 1 1
    SH3GLB1 DECR2 0 0 0 261 1 1
    SH3GLB1 GABARAP 0 0 341 420 1 2
    SH3GLB1 MTSS1L 0 0 161 161 1 1
    SH3GLB1 ACSL4 270 0 810 860 1 1
    SH3GLB1 SEC22C 0 0 0 177 1 1
    SH3GLB1 SNX32 0 0 136 190 1 1
    SH3GLB1 PPM1G 0 0 451 451 1 1
    SH3GLB1 XPO7 735 0 0 735 1 1
    SH3GLB1 SEC22A 0 0 146 612 1 1
    SH3GLB1 RPS20 0 0 0 239 1 1
    SH3GLB1 KIAA0226 0 0 629 659 1 1
    SH3GLB1 DNM1L 0 0 573 606 1 2
    SH3GLB1 WIPI1 0 0 457 457 1 2
    SH3GLB1 NOSTRIN 0 0 170 169 1 1
    SH3GLB1 PI4KB 0 0 90 328 1 1
    SH3GLB1 STARD8 0 0 416 416 1 1
    SH3GLB1 TRIB1 0 0 0 226 1 1
    SH3GLB1 MIEF1 0 0 329 377 1 1
    SH3GLB1 EXOSC5 204 0 0 204 1 1
    SH3GLB1 HTATIP2 298 0 690 773 1 1
    SH3GLB1 RPTOR 0 0 185 241 1 2
    SH3GLB1 CALCOCO2 0 0 253 252 1 2
    SH3GLB1 ATG5 105 0 563 644 1 2
    SH3GLB1 HSP90B1 0 0 46 246 1 1
    SH3GLB1 NT5M 0 0 0 155 1 1
    SH3GLB1 TRAPPC6A 0 0 74 266 1 1
    SH3GLB1 AP4E1 0 0 108 319 1 1
    SH3GLB1 RPUSD4 0 0 0 156 1 1
    SH3GLB1 SNX6 0 0 142 201 1 1
    SH3GLB1 COMMD4 0 0 60 276 1 1
    SH3GLB1 MCL1 0 0 233 261 1 2
    SH3GLB1 FCGRT 187 0 0 187 1 1
    SH3GLB1 SLC25A17 0 0 0 189 1 1
    SH3GLB1 CYCS 0 0 273 273 1 1
    SH3GLB1 YIPF6 0 0 415 427 1 1
    SH3GLB1 HMGB1 0 0 180 179 1 2
    SH3GLB1 OPTN 0 0 193 193 1 2
    SH3GLB1 IGDCC4 0 0 0 159 1 1
    SH3GLB1 ATG4A 0 0 178 177 1 2
    SH3GLB1 FNBP1 0 0 210 244 1 1
    SH3GLB1 ITPR1 0 0 156 155 1 2
    SH3GLB1 MTM1 0 0 174 173 1 1
    SH3GLB1 TRAPPC5 0 0 184 406 1 1
    SH3GLB1 TXLNG 0 0 47 253 1 1
    SH3GLB1 ULK1 0 0 509 512 1 2
    SH3GLB1 PACSIN2 0 0 247 246 1 1
    SH3GLB1 STMN1 0 0 123 258 1 1
    SH3GLB1 SNX5 0 0 176 242 1 1
    SH3GLB1 MAPK8 0 0 261 261 1 2
    SH3GLB1 SEC22B 0 0 142 263 1 1
    SH3GLB1 PTK2 0 0 116 153 1 1
    SH3GLB1 NEB 0 0 60 657 1 1
    SH3GLB1 VAMP3 0 0 108 179 1 1
    SH3GLB1 GMEB2 0 0 165 185 1 1
    SH3GLB1 PACSIN3 0 0 166 165 1 1
    SH3GLB1 BPIFA1 0 0 0 302 1 1
    SH3GLB1 ATG10 0 0 556 575 1 2
    SH3GLB1 RANBP1 0 0 90 231 1 1
    SH3GLB1 SPHK1 62 0 453 465 1 2
    SH3GLB1 CDK5RAP3 0 0 106 200 1 1
    SH3GLB1 ACAP3 0 0 181 181 1 1
    SH3GLB1 AGFG1 244 0 66 291 1 1
    SH3GLB1 TUFM 0 0 129 152 1 1
    SH3GLB1 ITM2A 0 0 0 164 1 1
    SH3GLB1 MAP1LC3B 0 0 274 331 1 2
    SH3GLB1 RPRD1A 679 0 0 679 1 1
    SH3GLB1 RNASE6 0 0 127 426 1 1
    SH3GLB1 TNIP2 0 0 81 178 1 1
    SH3GLB1 AIP 0 0 0 155 1 1
    SH3GLB1 ANKHD1 0 0 124 314 1 1
    SH3GLB1 MYO5C 0 0 0 214 1 1
    SH3GLB1 LAMP2 0 0 152 236 1 2
    SH3GLB1 HNRNPA0 0 0 91 249 1 1
    SH3GLB1 RPL39 0 0 90 155 1 1
    SH3GLB1 FST 0 0 0 302 1 1
    SH3GLB1 FASLG 0 0 305 305 1 1
    SH3GLB1 BIN3 0 0 116 202 1 1
    SH3GLB1 TCEA3 0 0 0 165 1 1
    SH3GLB1 GOLGA2 0 0 91 182 1 1
    SH3GLB1 NELFB 0 0 107 170 1 1
    SH3GLB1 EI24 0 0 172 197 1 2
    SH3GLB1 COMMD5 0 0 150 678 1 1
    SH3GLB1 HOXC8 0 0 52 156 1 1
    SH3GLB1 IFNGR1 0 0 0 161 1 1
    SH3GLB1 OSTF1 0 0 90 154 1 1
    SH3GLB1 PAIP2B 0 0 0 212 1 1
    SH3GLB1 RNASE8 0 0 0 154 1 1
    SH3GLB1 TIAF1 0 0 47 212 1 1
    SH3GLB1 DCC 0 0 0 159 1 1
    SH3GLB1 CALR 245 0 45 248 1 1
    SH3GLB1 FUNDC1 128 0 112 192 1 2
    SH3GLB1 C16orf62 0 0 320 732 1 1
    SH3GLB1 LNX2 0 0 143 196 1 1
    SH3GLB1 NEBL 0 0 0 194 1 1
    SH3GLB1 RPA2 244 0 0 243 1 1
    SH3GLB1 COX18 0 0 113 174 1 1
    SH3GLB1 DNM1 0 0 371 546 1 1
    SH3GLB1 MFN1 0 0 334 446 1 1
    SH3GLB1 ADAM15 297 0 0 297 1 1
    SH3GLB1 TM2D2 0 0 150 188 1 1
    SH3GLB1 ULK2 0 0 414 431 1 2
    SH3GLB1 WARS 272 0 0 272 1 1
    SH3GLB1 CCDC22 682 0 193 898 1 1
    SH3GLB1 PMAIP1 0 0 193 193 1 1
    SH3GLB1 TRIP10 0 0 265 286 1 1
    SH3GLB1 TLX2 0 0 89 229 1 1
    SH3GLB1 SNX4 261 0 91 299 1 1
    SH3GLB1 SRRM4 0 0 235 235 1 1
    SH3GLB1 GORASP2 129 0 0 198 1 1
    SH3GLB1 ARHGAP10 0 0 152 151 1 1
    SH3GLB1 THBS1 0 0 64 166 1 1
    SH3GLB1 TEX2 0 0 184 366 1 1
    SH3GLB1 SNAP29 0 0 180 197 1 2
    SH3GLB1 BECN1 286 0 988 991 1 2
    SH3GLB1 DSCR3 735 0 228 918 1 1
    SH3GLB1 SNCA 0 0 167 167 1 2
    SH3GLB1 TMBIM1 0 0 125 188 1 1
    SH3GLB1 ZNF280D 0 0 163 163 1 1
    SH3GLB1 COPE 0 0 43 207 1 1
    SH3GLB1 DAPK1 0 0 323 341 1 2
    SH3GLB1 NIF3L1 245 0 0 244 1 1
    SH3GLB1 TMEM220 0 0 213 213 1 1
    SH3GLB1 ITPR3 0 0 164 163 1 1
    SH3GLB1 SMIM5 102 0 225 274 1 1
    SH3GLB1 RHOT1 0 0 107 189 1 1
    SH3GLB1 POLDIP3 0 0 91 241 1 1
    SH3GLB1 AMACR 0 0 0 189 1 1
    SH3GLB1 SLC40A1 0 0 61 363 1 1
    SH3GLB1 BCL2L11 0 0 162 168 1 1
    SH3GLB1 SNX1 171 0 74 199 1 1
    SH3GLB1 SPATA19 0 0 160 159 1 1
    SH3GLB1 ERGIC3 0 0 112 151 1 1
    SH3GLB1 MEAF6 0 0 180 179 1 1
    SH3GLB1 VPS29 0 0 95 457 1 1
    SH3GLB1 SNTB1 0 0 95 436 1 1
    SH3GLB1 CASP3 0 0 175 175 1 2
    SH3GLB1 MMADHC 0 0 0 181 1 1
    SH3GLB1 C17orf50 0 0 155 154 1 1
    SH3GLB1 RANGAP1 245 0 0 244 1 1
    SH3GLB1 SH3GL2 0 0 530 277 1 1
    SH3GLB1 LASP1 0 0 0 194 1 1
    SH3GLB1 ATG101 0 0 467 467 1 2
    SH3GLB1 IL3 0 0 306 306 1 1
    SH3GLB1 TFEB 0 0 195 195 1 2
    SH3GLB1 KLF14 0 0 0 150 1 1
    SH3GLB1 GNG2 0 0 84 242 1 1
    SH3GLB1 ATG4D 0 0 234 250 1 2
    SH3GLB1 MRPS10 0 0 0 175 1 1
    SH3GLB1 FCHSD1 0 0 167 167 1 1
    SH3GLB1 ANKHD1-EIF4EBP3 0 0 0 250 1 1
    SH3GLB1 ULK4 0 0 142 189 1 1
    SH3GLB1 DIRAS3 0 0 155 154 1 2
    SH3GLB1 SUB1 256 0 72 280 1 1
    SH3GLB1 BNIP3 0 0 321 321 1 2
    SH3GLB1 SQSTM1 59 0 406 417 1 2
    SH3GLB1 SEPT7 265 0 0 282 1 1
    SH3GLB1 C1orf186 273 0 0 273 1 1
    SH3GLB1 ATG12 63 0 529 549 1 2
    SH3GLB1 ATG13 0 0 503 503 1 2
    SH3GLB1 TES 0 0 0 238 1 1
    SH3GLB1 PFDN4 0 0 0 179 1 1
    SH3GLB1 SPG7 0 0 122 176 1 1
    SH3GLB1 PGAM2 245 0 0 244 1 1
    SH3GLB1 TMEM95 0 0 241 240 1 1
    SH3GLB1 RCN2 0 0 123 277 1 1
    SH3GLB1 MRPS18B 0 0 46 211 1 1
    SH3GLB1 PFDN6 0 0 0 246 1 1
    SH3GLB1 GMEB1 0 0 134 195 1 1
    SH3GLB1 KLHDC10 311 0 0 311 1 1
    SH3GLB1 BAX 677 0 142 711 1 2
    SH3GLB1 AARSD1 129 0 0 253 1 1
    SH3GLB1 CMTM5 128 0 0 225 1 1
    SH3GLB1 ATG9A 0 0 304 378 1 2
    SH3GLB1 RHOA 0 0 290 290 1 1
    SH3GLB1 PRCC 265 0 0 265 1 1
    SH3GLB1 HSPA8 0 0 194 194 1 2
    SH3GLB1 CREG1 0 0 90 333 1 1
    SH3GLB1 HDAC1 0 0 55 254 1 2
    SH3GLB1 ASAP3 0 0 161 161 1 1
    SH3GLB1 TOMM22 63 0 193 225 1 1
    SH3GLB1 GABARAPL1 0 0 454 519 1 2
    SH3GLB1 IGDCC3 0 0 0 159 1 1
    SH3GLB1 RALB 0 0 96 173 1 1
    SH3GLB1 ATG16L1 0 0 468 468 1 2
    SH3GLB1 RAB1A 0 0 134 238 1 2
    SH3GLB1 COMMD2 0 0 161 438 1 1
    SH3GLB1 XKR8 0 0 113 395 1 1
    SH3GLB1 DNMBP 0 0 256 256 1 1
    SH3GLB1 ATG3 0 0 503 509 1 2
    SH3GLB1 SYVN1 0 0 112 205 1 1
    SH3GLB1 PLEK 0 0 329 329 1 1
    SH3GLB1 ANKRD17 0 0 108 674 1 1
    SH3GLB1 TRIM28 0 0 140 163 1 2
    SH3GLB1 CD93 0 0 53 197 1 1
    SH3GLB1 BAIAP2L2 0 0 183 183 1 1
    SH3GLB1 ACTR2 129 0 0 171 1 1
    SH3GLB1 BCL2L2-PABPN1 0 0 127 214 1 1
    SH3GLB1 ZBTB24 0 0 170 169 1 1
    SH3GLB1 KBTBD7 0 0 160 388 1 1
    SH3GLB1 SERPINB3 431 0 0 441 1 1
    SH3GLB1 RNASE7 0 0 0 154 1 1
    SH3GLB1 PIK3C3 270 0 707 782 1 2
    SH3GLB1 MTMR3 0 0 233 248 1 2
    SH3GLB1 EEA1 0 0 241 336 1 1
    SH3GLB1 COMMD10 0 0 218 443 1 1
    SH3GLB1 FLAD1 272 0 0 272 1 1
    SH3GLB1 TRIB2 0 0 0 327 1 1
    SH3GLB1 FOXO3 0 0 171 181 1 2
    SH3GLB1 MTOR 0 0 322 321 1 2
    SH3GLB1 LRRC40 0 0 207 422 1 1
    SH3GLB1 ADCK3 684 0 0 684 1 1
    SH3GLB1 LAP3 245 0 0 244 1 1
    SH3GLB1 TRAPPC8 0 0 103 164 1 1
    SH3GLB1 SRC 0 0 156 155 1 1
    SH3GLB1 ATG4C 0 0 517 517 1 2
    SH3GLB1 GHITM 63 0 90 193 1 1
    SH3GLB1 TPRA1 0 0 139 162 1 1
    SH3GLB1 DNM3 0 0 0 165 1 1
    SH3GLB1 ARFIP1 0 0 260 523 1 1
    SH3GLB1 BNIP3L 0 0 337 351 1 2
    SH3GLB1 SNX18 0 0 235 249 1 2
    SH3GLB1 VDAC1 0 0 205 222 1 2
    SH3GLB1 DIS3 261 0 0 261 1 1
    SH3GLB1 RNF24 0 0 140 364 1 1
    SH3GLB1 RAB7B 0 0 376 425 1 1
    SH3GLB1 KBTBD6 0 0 156 241 1 1
    SH3GLB1 NEO1 0 0 0 159 1 1
    SH3GLB1 TSC2 0 0 251 250 1 2
    SH3GLB1 ZFYVE1 0 0 324 350 1 2
    SH3GLB1 MFN2 0 0 373 415 1 2
    SH3GLB1 DHCR24 0 0 113 150 1 1
    SH3GLB1 TXLNA 0 0 0 359 1 1
    SH3GLB1 USP7 195 0 0 195 1 1
    SH3GLB1 MAP1LC3A 0 0 234 271 1 2
    SH3GLB1 NRBF2 0 0 286 329 1 2
    SH3GLB1 MTFP1 0 0 349 349 1 1
    SH3GLB1 DPCD 0 0 0 262 1 1
    SH3GLB1 ATG2B 0 0 373 625 1 2
    SH3GLB1 SELENBP1 0 0 0 548 1 1
    SH3GLB1 TRAPPC6B 0 0 0 153 1 1
    SH3GLB1 BIN1 213 0 609 723 1 1
    SH3GLB1 RAB11A 0 0 108 182 1 1
    SH3GLB1 RAB5A 270 0 325 513 1 2
    SH3GLB1 TOMM20 0 0 193 193 1 1
    SH3GLB1 STX17 0 0 325 339 1 2
    SH3GLB1 SP1 0 0 62 244 1 1
    SH3GLB1 MARCH5 0 0 323 355 1 1
    SH3GLB1 HIF1A 0 0 127 162 1 2
    SH3GLB1 GOLGA6L2 0 0 0 185 1 1
    SH3GLB1 CCZ1 0 0 123 212 1 1
    SH3GLB1 EIF2S1 0 0 134 167 1 2
    SH3GLB1 COMMD3 679 0 125 738 1 1
    SH3GLB1 ZNF398 0 0 45 251 1 1
    SH3GLB1 DCTN5 0 0 142 174 1 1
    SH3GLB1 NMI 0 0 0 288 1 1
    SH3GLB1 GABARAPL2 0 0 460 504 1 2
    SH3GLB1 TPD52L2 684 0 0 684 1 1
    SH3GLB1 ARHGEF37 0 0 181 181 1 1
    SH3GLB1 ATG14 0 0 792 792 1 2
    SH3GLB1 NOP9 0 0 287 286 1 1
    SH3GLB1 CCDC50 0 0 0 188 1 1
    SH3GLB1 PARL 0 0 175 175 1 1
    SH3GLB1 VMP1 0 0 364 401 1 2
    SH3GLB1 FYCO1 0 0 194 194 1 2
    SH3GLB1 RNPS1 0 0 0 212 1 1
    SH3GLB1 AKT1 0 0 261 261 1 2
    SH3GLB1 RAB33B 0 0 168 167 1 2
    SH3GLB1 CAPN1 0 0 156 174 1 2
    SH3GLB1 PPP1R9B 0 0 0 171 1 1
    SH3GLB1 PRKRIP1 0 0 229 228 1 1
    SH3GLB1 BCL2L1 0 0 369 369 1 2
    SH3GLB1 MBOAT2 0 0 643 643 1 1
    SH3GLB1 MAPK8IP1 0 0 170 172 1 1
    SH3GLB1 AP2M1 0 0 113 198 1 1
    SH3GLB1 LGALS3BP 0 0 49 195 1 1
    SH3GLB1 MTMR14 0 0 186 186 1 1
    SH3GLB1 SYNJ2 0 0 0 153 1 1
    SH3GLB1 PIK3R4 0 0 596 596 1 2
    SH3GLB1 MAPRE2 0 0 143 175 1 1
    SH3GLB1 SPG21 0 0 107 171 1 1
    SH3GLB1 YME1L1 0 0 81 172 1 1
    SH3GLB1 ITM2B 0 0 0 195 1 1
    SH3GLB1 CARD6 0 0 96 336 1 1
    SH3GLB1 RIC8A 256 0 0 256 1 1
    SH3GLB1 NGF 0 0 161 180 1 1
    SH3GLB1 SH3GLB2 759 0 925 767 1 1
    SH3GLB1 WASL 0 0 397 397 1 1
    SH3GLB1 DENR 0 0 321 321 1 1
    SH3GLB1 COMMD9 0 0 211 332 1 1
    SH3GLB1 ARFIP2 129 0 253 426 1 1
    SH3GLB1 CCZ1B 0 0 123 212 1 1
    SH3GLB1 SH3KBP1 270 0 604 703 1 1
    SH3GLB1 PINK1 0 0 266 266 1 2
    SH3GLB1 PTGES3L-AARSD1 0 0 0 177 1 1
    SH3GLB1 THG1L 245 0 0 380 1 1
    SH3GLB1 UBE2D3 0 0 0 157 1 1
    SH3GLB1 GADD45A 111 0 0 296 1 1
    SH3GLB1 CDKN2D 204 0 0 204 1 1
    SH3GLB1 OPA1 0 0 163 202 1 1
    SH3GLB1 MFF 0 0 364 403 1 1
    SH3GLB1 SYNJ1 213 0 666 773 1 1
    SH3GLB1 STK11 0 0 218 232 1 2
    SH3GLB1 WDFY3 0 0 288 319 1 2
    SH3GLB1 UVRAG 486 0 988 994 1 2
    SH3GLB1 STRN 0 0 0 213 1 1
    SH3GLB1 MAPK1 0 0 142 192 1 2
    SH3GLB1 TOE1 245 0 0 244 1 1
    SH3GLB1 RNF41 0 0 0 200 1 1
    SH3GLB1 PIGT 0 0 112 203 1 1
    SH3GLB1 FCHO2 0 0 141 153 1 1
    SH3GLB1 RB1CC1 0 0 519 519 1 2
    SH3GLB1 GDAP1 0 0 341 401 1 1
    SH3GLB1 SEPT11 234 0 0 263 1 1
    SH3GLB1 ICA1L 0 0 160 159 1 1
    SH3GLB1 ODF2L 0 0 217 698 1 1
    SH3GLB1 IER5 0 0 95 280 1 1
    SH3GLB1 PARK7 0 0 150 188 1 1
    SH3GLB1 CEP97 0 0 0 210 1 1
    SH3GLB1 VWF 0 0 0 216 1 1
    SH3GLB1 TAX1BP1 118 0 0 151 1 2
    SH3GLB1 SDCBP 0 0 0 181 1 1
    SH3GLB1 GOLPH3 0 0 161 161 1 1
    SH3GLB1 FAM49B 0 0 139 464 1 1
    SH3GLB1 ATG4B 0 0 321 321 1 2
    SH3GLB1 AP2A2 0 0 171 208 1 1
    SH3GLB1 MTA1 213 0 0 213 1 1
    SH3GLB1 DRAM1 0 0 322 321 1 2
    SH3GLB1 ITSN2 0 0 0 190 1 1
    SH3GLB1 TBCB 0 0 108 163 1 1
    SH3GLB1 RPUSD1 0 0 0 156 1 1
    SH3GLB1 RAB7A 0 0 391 481 1 2
    SH3GLB1 SH3GL3 0 0 233 213 1 1
    SH3GLB1 PTGES3L 0 0 0 177 1 1
    SH3GLB1 MAL2 128 0 0 225 1 1
    SH3GLB1 FNBP1L 0 0 125 163 1 1
    SH3GLB1 ITM2C 0 0 0 164 1 1
    SH3GLB1 KLHL21 0 0 135 174 1 1
    SH3GLB1 FIS1 0 0 500 505 1 2
    SH3GLB1 LRP5L 0 0 229 234 1 1
    SH3GLB1 WIPI2 0 0 367 367 1 2
    SH3GLB1 KIAA1279 244 0 0 243 1 1
    SH3GLB1 ZNF207 195 0 0 231 1 1
    SH3GLB1 WDR64 0 0 0 171 1 1
    SH3GLB1 CAP1 0 0 0 154 1 1
    SH3GLB1 STRN4 0 0 0 177 1 1
    SH3GLB1 USP14 661 0 0 661 1 1
    SH3GLB1 ITCH 270 0 0 279 1 1
    SH3GLB1 APPL1 0 0 162 282 1 1
    SH3GLB1 ZFYVE26 0 0 162 161 1 1
    SH3GLB1 RPUSD3 0 0 0 156 1 1
    SH3GLB1 NBR1 0 0 322 321 1 2
    SH3GLB1 SDK2 0 0 0 160 1 1
    SH3GLB1 DDX27 245 0 0 244 1 1
    SH3GLB1 PARK2 0 0 161 161 1 1
    SH3GLB1 STARD13 0 0 270 270 1 1
    SH3GLB1 SERPINB13 187 0 0 201 1 1
    SH3GLB1 TAX1BP3 0 0 0 166 1 1
    SH3GLB1 IRGM 270 0 521 636 1 2
    SH3GLB1 MYC 44 0 150 152 1 2
    SH3GLB1 ZNF576 247 0 0 246 1 1
    SH3GLB1 STRN3 0 0 0 213 1 1
    SH3GLB1 ABHD5 129 0 0 161 1 1
    SH3GLB1 CWC22 0 0 103 197 1 1
    SH3GLB1 GRIA1 0 0 416 428 1 1
    SH3GLB1 ATG2A 0 0 202 289 1 2
    SH3GLB1 CD300C 0 0 261 261 1 1
    SH3GLB1 FCHO1 0 0 147 159 1 1
    SH3GLB1 RAB9A 0 0 0 150 1 2
    SH3GLB1 ADAM9 213 0 0 213 1 1
    SH3GLB1 KIF14 270 0 0 270 1 1
    SH3GLB1 HMHA1 0 0 180 179 1 1
    SH3GLB1 DHRS7 0 0 148 191 1 1
    SH3GLB1 EIF2AK4 0 0 113 236 1 1
    SH3GLB1 MSRB3 0 0 90 247 1 1
    SH3GLB1 SIVA1 0 0 90 363 1 1
    SH3GLB1 RIMKLB 0 0 182 351 1 1
    SH3GLB1 TPRKB 245 0 0 244 1 1
    SH3GLB1 TECPR1 0 0 231 273 1 2
    SH3GLB1 CHORDC1 261 0 0 261 1 1
    SH3GLB1 ITSN1 0 0 0 190 1 1
    SH3GLB1 HSCB 270 0 0 270 1 1
    SH3GLB1 RHEB 0 0 241 240 1 2
    SH3GLB1 HDAC6 0 0 134 159 1 2
    SH3GLB1 MAP1A 0 0 127 175 1 1
    SH3GLB1 PPP2R5D 263 0 0 263 1 1
    SH3GLB1 SNX9 0 0 235 235 1 1
    SH3GLB1 UBE2I 272 0 0 272 1 1
    SH3GLB1 HSPBP1 129 0 0 234 1 1
    SH3GLB1 HDAC2 0 0 57 156 1 1
    SH3GLB1 BCL2L2 0 0 154 153 1 1
    SH3GLB1 LPP 129 0 0 169 1 1
    SH3GLB1 CUL2 311 0 56 377 1 1
    SH3GLB1 TCOF1 311 0 0 311 1 1
    SH3GLB1 ARPC2 245 0 0 244 1 1
    SH3GLB1 CMTM6 0 0 0 246 1 1
    SH3GLB1 FAM63A 0 0 160 159 1 1
    SH3GLB1 PSTPIP2 0 0 233 416 1 1
    SH3GLB1 SERPINA4 0 0 56 225 1 1
    SH3GLB1 ULK3 0 0 202 220 1 2
    SH3GLB1 HTT 213 0 306 495 1 1
    SH3GLB1 EGFR 0 0 157 188 1 1
    SH3GLB1 CFLAR 0 0 96 192 1 1
    SH3GLB1 PSTPIP1 0 0 134 193 1 1
    SH3GLB1 ANKRD18A 0 0 217 217 1 1
    SH3GLB1 LAMP1 0 0 190 222 1 2
    SH3GLB1 CDK1 0 0 95 175 1 1
    SH3GLB1 FAM177B 0 0 107 168 1 1
    SH3GLB1 COMMD8 0 0 61 220 1 1
    SH3GLB1 NTRK1 0 0 820 820 1 1
    SH3GLB1 UXT 0 0 609 609 1 1
    SH3GLB1 TP53 0 0 205 205 1 2
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0045296 Molecular Function cadherin binding enables HDA
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0008289 Molecular Function lipid binding enables IEA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0042803 Molecular Function protein homodimerization activity enables IPI
    GO:0006915 Biological Process apoptotic process involved_in IEA
    GO:0048102 Biological Process autophagic cell death involved_in IMP
    GO:0006914 Biological Process autophagy involved_in IEA
    GO:0034198 Biological Process cellular response to amino acid starvation involved_in IMP
    GO:0042149 Biological Process cellular response to glucose starvation involved_in IMP
    GO:0090148 Biological Process membrane fission involved_in IMP
    GO:0061024 Biological Process membrane organization involved_in IBA
    GO:2000786 Biological Process positive regulation of autophagosome assembly involved_in IMP
    GO:0010508 Biological Process positive regulation of autophagy involved_in IMP
    GO:1903527 Biological Process positive regulation of membrane tubulation involved_in IMP
    GO:1903955 Biological Process positive regulation of protein targeting to mitochondrion involved_in HMP
    GO:0031334 Biological Process positive regulation of protein-containing complex assembly involved_in IDA
    GO:1903778 Biological Process protein localization to vacuolar membrane involved_in IMP
    GO:0032801 Biological Process receptor catabolic process involved_in IMP
    GO:0032465 Biological Process regulation of cytokinesis involved_in IMP
    GO:0016241 Biological Process regulation of macroautophagy involved_in TAS
    GO:0031647 Biological Process regulation of protein stability involved_in HMP
    GO:0000139 Cellular Component Golgi membrane located_in IEA
    GO:0000421 Cellular Component autophagosome membrane located_in IDA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0031410 Cellular Component cytoplasmic vesicle located_in IEA
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0016020 Cellular Component membrane is_active_in IBA
    GO:0030496 Cellular Component midbody located_in IDA
    GO:0005741 Cellular Component mitochondrial outer membrane located_in IEA
    GO:0016604 Cellular Component nuclear body located_in IDA
    GO:0032991 Cellular Component protein-containing complex part_of IDA
    Pathways
    Name DB ID
    Nanoparticle triggered autophagic cell death (WP2509) WikiPathways WP2509_r101755
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XM_006710672 3 mRNA transcript variant X1 NC_000001 Reference
    NM_001206651 2 mRNA transcript variant 2 NC_000001 Reference
    NM_001206652 2 mRNA transcript variant 3 NC_000001 Reference
    NM_001410824 1 mRNA transcript variant 5 NC_000001 Reference
    NM_016009 5 mRNA transcript variant 1 NC_000001 Reference
    XM_006710673 3 mRNA transcript variant X2 NC_000001 Reference
    NM_001206653 2 mRNA transcript variant 4 NC_000001 Reference
    XM_017001409 2 mRNA transcript variant X3 NC_000001 Reference
    XM_017001410 3 mRNA transcript variant X4 NC_000001 Reference