BECN2

beclin 2
General Information
Name beclin 2
Alias
  • beclin-2
  • Beclin-1-like protein 1
  • beclin-1 autophagy-related pseudogene 1
Synonyms BECN1L1 BECN1P1
Gene_family None
organism Homo sapiens
entrez_id 441925
location 1q43
transcript_count 1
exon_count 1
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Acts upstream of or within G protein-coupled receptor catabolic process; autophagy; and endosome to lysosome transport. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. [provided by Alliance of Genome Resources, Mar 2025]
      nextProt Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    BECN2 BioGRID MYCN GeneID BioGRID Affinity Capture-MS
    BECN2 BioGRID TP53INP2 GeneID BioGRID Two-hybrid
    BECN2 BioGRID AMBRA1 GeneID BioGRID Affinity Capture-Western
    BECN2 BioGRID ATG14 GeneID BioGRID Affinity Capture-Western; Co-crystal Structure
    BECN2 BioGRID GPRASP1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    BECN2 BioGRID RUBCN GeneID BioGRID Affinity Capture-Western
    BECN2 BioGRID UVRAG GeneID BioGRID Affinity Capture-Western
    BECN2 BioGRID HMGB1 GeneID BioGRID Affinity Capture-Western
    BECN2 BioGRID CNR1 GeneID BioGRID Two-hybrid
    BECN2 BioGRID ADRB2 GeneID BioGRID Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0043548 Molecular Function phosphatidylinositol 3-kinase binding enables IBA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0044877 Molecular Function protein-containing complex binding enables IEA
    GO:0030674 Molecular Function protein-macromolecule adaptor activity enables IBA
    GO:1990172 Biological Process G protein-coupled receptor catabolic process involved_in IMP
    GO:1990172 Biological Process G protein-coupled receptor catabolic process acts_upstream_of_or_within IPI
    GO:0000045 Biological Process autophagosome assembly involved_in IBA
    GO:0006914 Biological Process autophagy acts_upstream_of_or_within IMP
    GO:0006914 Biological Process autophagy involved_in IMP
    GO:0006995 Biological Process cellular response to nitrogen starvation involved_in IBA
    GO:0008333 Biological Process endosome to lysosome transport acts_upstream_of_or_within IMP
    GO:0008333 Biological Process endosome to lysosome transport involved_in IMP
    GO:0042593 Biological Process glucose homeostasis involved_in IEA
    GO:0045324 Biological Process late endosome to vacuole transport involved_in IBA
    GO:0000423 Biological Process mitophagy involved_in IBA
    GO:0000407 Cellular Component phagophore assembly site is_active_in IBA
    GO:0034271 Cellular Component phosphatidylinositol 3-kinase complex, class III, type I part_of IBA
    GO:0034272 Cellular Component phosphatidylinositol 3-kinase complex, class III, type II part_of IBA
    Pathways
    Name DB ID
    Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
    Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001290693 1 mRNA None NC_000001 Reference