MEFV

MEFV innate immunity regulator, pyrin
General Information
Name MEFV innate immunity regulator, pyrin
Alias
  • pyrin
  • MEFV, pyrin innate immunity regulator
  • Mediterranean fever
  • marenostrin
Synonyms FMF TRIM20 MEF PAAND
Gene_family Tripartite motif family|Pyrin domain containing
organism Homo sapiens
entrez_id 4210
location 16p13.3
transcript_count 2
exon_count 10
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008]
      Stringdb Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18- mediated inflammation. However, i [...]
      nextProt Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923, PubMed:16037825, PubMed:27030597, PubMed:28835462, PubMed:16785446, PubMed:17431422, PubMed:26347139). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:16785446, PubMed:17431422, PubMed:26347139). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    MEFV BioGRID UBE2O GeneID BioGRID Affinity Capture-MS
    MEFV BioGRID SPICE1 GeneID BioGRID Affinity Capture-MS
    MEFV BioGRID H1-2 GeneID BioGRID Proximity Label-MS
    MEFV BioGRID PRKD2 GeneID BioGRID Affinity Capture-MS
    MEFV BioGRID PSTPIP1 GeneID BioGRID Affinity Capture-Western
    MEFV BioGRID LGALS8 GeneID BioGRID Reconstituted Complex
    MEFV BioGRID LGALS3 GeneID BioGRID Reconstituted Complex
    MEFV BioGRID MAP1LC3C GeneID BioGRID Reconstituted Complex
    MEFV BioGRID NLRP3 GeneID BioGRID Affinity Capture-Western
    MEFV BioGRID MAP1LC3A GeneID BioGRID Reconstituted Complex
    MEFV BioGRID ATG16L1 GeneID BioGRID Affinity Capture-Western
    MEFV BioGRID GABARAPL1 GeneID BioGRID Reconstituted Complex
    MEFV BioGRID GABARAPL2 GeneID BioGRID Reconstituted Complex
    MEFV BioGRID GABARAP GeneID BioGRID Protein-peptide; Reconstituted Complex
    MEFV BioGRID BECN1 GeneID BioGRID Affinity Capture-Western
    MEFV BioGRID ULK1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    MEFV BioGRID SIVA1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    MEFV Protein COG5 GeneID HPRD None
    MEFV Protein PYCARD GeneID HPRD None
    MEFV Protein PSTPIP1 GeneID HPRD None
    MEFV BioGRID PYCARD GeneID BioGRID Affinity Capture-Western; Two-hybrid
    MEFV BioGRID COG5 GeneID BioGRID Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    MEFV HIST1H4L 0 0 53 164 1 1
    MEFV AGO4 0 0 0 169 1 1
    MEFV MPEG1 0 0 75 155 1 1
    MEFV SRI 0 0 143 160 1 1
    MEFV UBE2K 0 0 0 161 1 1
    MEFV NLRP10 0 0 565 282 1 1
    MEFV TLR1 0 0 408 472 1 1
    MEFV PGAM5 0 0 137 184 1 1
    MEFV VASP 0 0 357 357 1 1
    MEFV IKZF3 0 0 0 157 1 1
    MEFV DHX58 0 0 403 440 1 1
    MEFV RBCK1 0 0 223 245 1 1
    MEFV ASGR1 0 0 0 270 1 1
    MEFV CD80 0 0 139 180 1 1
    MEFV NLRP12 0 0 710 743 1 1
    MEFV IL18 0 0 813 831 1 1
    MEFV IRGM 0 0 416 416 1 2
    MEFV MYC 0 0 157 189 1 2
    MEFV IL1R1 0 0 509 509 1 1
    MEFV HIST1H2BD 0 0 0 155 1 1
    MEFV TREM1 0 0 93 183 1 1
    MEFV LILRA1 0 0 0 167 1 1
    MEFV TAB2 0 0 253 267 1 1
    MEFV DHX33 0 0 295 322 1 1
    MEFV MX1 0 0 139 178 1 1
    MEFV TAB1 0 0 202 224 1 1
    MEFV CECR1 0 0 265 291 1 1
    MEFV BTN3A2 0 0 112 181 1 1
    MEFV LY86 0 0 107 181 1 1
    MEFV CYBA 0 0 180 197 1 1
    MEFV FGR 0 0 0 202 1 1
    MEFV PIN1 0 0 0 158 1 1
    MEFV SIVA1 270 0 95 311 1 1
    MEFV TRIM23 0 0 208 279 1 1
    MEFV STAT3 0 0 269 285 1 2
    MEFV AGO2 0 0 0 169 1 1
    MEFV IRF9 0 0 181 181 1 1
    MEFV MYD88 0 0 560 572 1 1
    MEFV PSTPIP1 678 800 989 999 1 1
    MEFV HIST1H4I 0 0 53 164 1 1
    MEFV ESX1 0 0 207 229 1 1
    MEFV FADD 0 0 404 404 1 2
    MEFV SARM1 0 0 203 203 1 1
    MEFV CAMP 0 0 218 240 1 1
    MEFV TRAF1 0 0 157 204 1 1
    MEFV CSF3 0 0 181 204 1 1
    MEFV CRADD 0 0 395 394 1 1
    MEFV EDARADD 0 0 0 156 1 1
    MEFV TRIM40 0 0 112 261 1 1
    MEFV CD40LG 0 0 193 218 1 1
    MEFV SPSB3 0 0 170 169 1 1
    MEFV PIDD1 0 0 391 426 1 1
    MEFV SAA1 0 0 469 469 1 1
    MEFV DDX21 0 0 156 188 1 1
    MEFV APOBEC3G 0 0 74 154 1 1
    MEFV SYT7 0 0 43 168 1 1
    MEFV NLRP1 0 0 916 918 1 1
    MEFV NFYB 0 0 0 162 1 1
    MEFV IL6 0 0 561 572 1 1
    MEFV ZIK1 0 0 118 150 1 1
    MEFV SCAF11 0 0 180 179 1 1
    MEFV MPO 0 0 299 314 1 1
    MEFV MYSM1 0 0 57 157 1 1
    MEFV TNFRSF1A 0 0 611 619 1 1
    MEFV TRIM37 0 0 232 316 1 1
    MEFV IL1B 0 0 865 895 1 1
    MEFV TRIM66 0 0 90 239 1 1
    MEFV TRAF5 0 0 170 169 1 1
    MEFV TRPM7 0 0 92 150 1 1
    MEFV TRIM13 0 0 117 157 1 2
    MEFV CDC73 0 0 0 188 1 1
    MEFV FCGR3A 0 0 91 161 1 1
    MEFV MAP1LC3A 270 0 90 396 1 2
    MEFV TNFRSF1B 0 0 108 176 1 1
    MEFV CXCR2 0 0 140 249 1 1
    MEFV TAB3 0 0 171 187 1 2
    MEFV CLEC7A 0 0 374 482 1 1
    MEFV BCL2L1 0 0 202 214 1 2
    MEFV TRIM72 0 0 203 175 1 1
    MEFV TLR4 0 0 612 626 1 1
    MEFV NOS2 0 0 125 162 1 1
    MEFV GABARAPL2 270 0 237 501 1 2
    MEFV APOA1 0 0 92 221 1 1
    MEFV KCNJ11 0 0 597 603 1 1
    MEFV TTC7A 0 0 170 188 1 1
    MEFV CCL5 0 0 300 394 1 1
    MEFV CADM3 0 0 113 355 1 1
    MEFV PLCG2 0 0 230 248 1 1
    MEFV BIRC2 0 0 228 303 1 1
    MEFV IFNG 0 0 284 371 1 2
    MEFV ANXA5 0 0 164 163 1 1
    MEFV ABAT 0 0 0 165 1 1
    MEFV CLEC4D 0 0 97 221 1 1
    MEFV GSDMA 0 0 500 524 1 1
    MEFV SIGLEC7 0 0 0 152 1 1
    MEFV APOBEC3A 0 0 0 218 1 1
    MEFV CD8A 0 0 321 321 1 1
    MEFV PSMB8 0 0 256 269 1 1
    MEFV TNFSF4 0 0 95 150 1 1
    MEFV RIPK2 0 0 556 563 1 1
    MEFV YWHAE 0 800 911 981 1 1
    MEFV TICAM1 0 0 297 297 1 1
    MEFV IL37 0 0 181 203 1 1
    MEFV CCR5 0 0 154 200 1 1
    MEFV WDR5 0 0 46 159 1 1
    MEFV DPP9 0 0 155 171 1 1
    MEFV IL10RA 0 0 185 250 1 1
    MEFV TMEM173 0 0 401 420 1 1
    MEFV CASP1 270 800 989 999 1 2
    MEFV OOEP 0 0 193 208 1 1
    MEFV FFAR2 0 0 142 285 1 1
    MEFV GBP4 0 0 57 207 1 1
    MEFV ACTB 0 0 322 353 1 1
    MEFV INS 0 0 241 240 1 1
    MEFV SPAG7 0 0 218 218 1 1
    MEFV RPS6KA6 0 800 0 803 1 1
    MEFV CD40 0 0 210 230 1 1
    MEFV FPR2 0 0 143 262 1 1
    MEFV BRCC3 0 0 181 195 1 1
    MEFV B2M 0 0 156 155 1 1
    MEFV FCGR2B 0 0 107 186 1 1
    MEFV TRIM73 0 0 103 262 1 1
    MEFV HIST1H4J 0 0 53 164 1 1
    MEFV KDM1B 0 0 0 172 1 1
    MEFV MLKL 0 0 391 423 1 1
    MEFV NLRP9 0 0 630 640 1 1
    MEFV IL22 0 0 150 165 1 1
    MEFV GABARAPL1 270 0 143 466 1 2
    MEFV UNC93B1 0 0 157 176 1 1
    MEFV RHOA 0 0 327 337 1 1
    MEFV PARP1 0 0 181 193 1 2
    MEFV TLR5 0 0 456 476 1 1
    MEFV TMLHE 0 0 307 325 1 1
    MEFV TPM1 0 0 0 169 1 1
    MEFV AIM2 0 0 974 976 1 1
    MEFV DDX58 0 0 617 634 1 1
    MEFV PYDC2 0 0 616 616 1 1
    MEFV HIST1H4E 0 0 53 164 1 1
    MEFV TPM4 0 0 0 169 1 1
    MEFV TRIM21 0 0 425 162 1 1
    MEFV FICD 0 0 45 152 1 1
    MEFV RNF31 0 0 184 201 1 1
    MEFV FECH 0 0 0 228 1 1
    MEFV IAPP 0 0 264 265 1 1
    MEFV MAVS 0 0 557 565 1 1
    MEFV IL1A 0 0 504 618 1 1
    MEFV MAP1LC3C 270 0 66 375 1 2
    MEFV CCL4 0 0 150 222 1 1
    MEFV CASP8 0 0 755 785 1 2
    MEFV DCLK1 0 0 0 171 1 1
    MEFV LRRFIP1 0 0 305 312 1 1
    MEFV CD276 0 0 96 192 1 1
    MEFV RPS6KA3 0 800 46 804 1 1
    MEFV TLR7 0 0 459 505 1 1
    MEFV CASP9 0 0 325 325 1 1
    MEFV SPICE1 274 0 0 274 1 1
    MEFV NLRP5 0 0 506 513 1 1
    MEFV IL17A 0 0 401 400 1 1
    MEFV TMEM59 0 0 125 259 1 1
    MEFV TRIM5 0 0 452 193 1 2
    MEFV ACAD10 0 0 0 153 1 1
    MEFV TRIM35 0 0 161 170 1 1
    MEFV DEFB103B 0 0 156 155 1 1
    MEFV IFIH1 0 0 517 539 1 1
    MEFV HIST2H3PS2 0 0 92 188 1 1
    MEFV GSDMB 0 0 149 202 1 1
    MEFV CISH 0 0 163 176 1 1
    MEFV MX2 0 0 113 183 1 1
    MEFV PRF1 0 0 144 169 1 1
    MEFV ARG1 0 0 95 172 1 1
    MEFV USP24 0 0 42 266 1 1
    MEFV IGHV4-38-2 0 0 268 268 1 1
    MEFV ADIPOQ 0 0 141 157 1 1
    MEFV C5AR2 0 0 118 273 1 1
    MEFV HLA-DQA1 0 0 113 189 1 1
    MEFV S100A9 0 0 113 176 1 1
    MEFV TXNIP 0 0 507 537 1 1
    MEFV IFI16 0 0 736 751 1 1
    MEFV IL1R2 0 0 193 271 1 1
    MEFV IL5 0 0 171 171 1 1
    MEFV RPS6KA2 0 800 43 803 1 1
    MEFV TNFAIP3 0 0 296 312 1 1
    MEFV ERAP2 0 0 81 172 1 1
    MEFV NFKB2 0 0 149 207 1 1
    MEFV IRF7 0 0 334 359 1 1
    MEFV FFAR3 0 0 123 155 1 1
    MEFV ITK 0 0 54 179 1 1
    MEFV IL1RN 0 0 466 494 1 1
    MEFV LPIN2 0 0 470 483 1 1
    MEFV NBR1 0 0 93 172 1 2
    MEFV TNF 0 0 564 613 1 1
    MEFV RNF135 0 0 166 165 1 1
    MEFV NAIP 0 0 709 719 1 1
    MEFV ARIH2 0 0 134 152 1 1
    MEFV CLEC10A 0 0 0 241 1 1
    MEFV RNASEL 0 0 195 259 1 1
    MEFV PTPN2 0 0 76 200 1 2
    MEFV CTLA4 0 0 176 175 1 1
    MEFV CAT 0 0 156 206 1 1
    MEFV PSMA3 0 0 123 157 1 1
    MEFV ZC3H12D 0 0 0 152 1 1
    MEFV DDX60 0 0 165 183 1 1
    MEFV FCGR1A 0 0 134 185 1 1
    MEFV LRRC25 0 0 0 160 1 1
    MEFV NLRP2 0 0 724 797 1 1
    MEFV HIST1H4B 0 0 53 164 1 1
    MEFV TRIM65 0 0 181 181 1 1
    MEFV HK3 0 0 0 160 1 1
    MEFV HP 0 0 95 152 1 1
    MEFV SRC 0 0 195 224 1 1
    MEFV EVA1A 0 0 134 166 1 2
    MEFV LGALS3 270 0 103 317 1 1
    MEFV TRIM52 0 0 134 227 1 1
    MEFV UTP14A 0 0 0 155 1 1
    MEFV LILRA5 0 0 0 214 1 1
    MEFV JAK1 0 0 170 188 1 1
    MEFV TRIM14 0 0 184 166 1 1
    MEFV HMOX1 0 0 180 179 1 2
    MEFV TICAM2 0 0 152 199 1 1
    MEFV IFIT1 0 0 156 169 1 1
    MEFV DPP8 0 0 194 209 1 1
    MEFV CARD14 0 0 315 329 1 1
    MEFV CARD8 0 0 645 662 1 1
    MEFV HIST1H2BA 0 0 0 155 1 1
    MEFV CD4 0 0 382 419 1 1
    MEFV PPARG 0 0 166 197 1 1
    MEFV CYTH4 0 0 0 151 1 1
    MEFV AKT1 0 0 261 273 1 2
    MEFV GBP2 0 0 176 268 1 1
    MEFV LY96 0 0 261 261 1 1
    MEFV IL12RB1 0 0 72 166 1 1
    MEFV XIAP 0 0 212 212 1 1
    MEFV PANX1 0 0 468 479 1 1
    MEFV IKBKB 0 0 324 335 1 1
    MEFV PDLIM2 0 0 0 217 1 1
    MEFV HIST3H2BB 0 0 0 171 1 1
    MEFV CXCL10 0 0 283 306 1 1
    MEFV MALT1 0 0 254 254 1 1
    MEFV SUPT16H 0 0 0 281 1 1
    MEFV IRF3 0 0 556 562 1 1
    MEFV TRIM2 0 0 96 161 1 1
    MEFV NLRP7 0 0 733 804 1 1
    MEFV PYCARD 865 800 942 981 1 1
    MEFV CFP 0 0 60 227 1 1
    MEFV CLEC12B 0 0 112 178 1 1
    MEFV TLR9 0 0 504 533 1 1
    MEFV ENSG00000257767 0 0 0 182 1 1
    MEFV EMR3 0 0 122 174 1 1
    MEFV PKN2 0 800 369 874 1 1
    MEFV MNDA 0 0 610 668 1 1
    MEFV IGSF6 0 0 52 276 1 1
    MEFV NUP155 0 0 0 162 1 1
    MEFV SOCS3 0 0 124 167 1 1
    MEFV FASLG 0 0 205 223 1 1
    MEFV FAF1 0 0 427 439 1 1
    MEFV IL18R1 0 0 150 199 1 1
    MEFV KCNJ15 0 0 0 150 1 1
    MEFV CARD11 0 0 149 167 1 1
    MEFV TLR6 0 0 342 471 1 1
    MEFV IL2 0 0 218 218 1 1
    MEFV ABCB1 0 0 72 171 1 1
    MEFV FBXL19 0 0 0 180 1 1
    MEFV BECN1 270 0 284 461 1 2
    MEFV HIST1H4G 0 0 0 153 1 1
    MEFV PIAS1 0 0 48 214 1 1
    MEFV IL13 0 0 236 236 1 1
    MEFV ACE 0 0 141 168 1 1
    MEFV TNFSF13B 0 0 118 204 1 1
    MEFV BMS1 0 0 54 172 1 1
    MEFV CYBB 0 0 283 322 1 1
    MEFV TRIM22 0 0 325 197 1 1
    MEFV NLRP3 270 0 990 638 1 2
    MEFV REL 0 0 181 238 1 1
    MEFV CARD16 0 0 415 740 1 1
    MEFV PLA2G6 0 0 0 172 1 1
    MEFV PTGS2 0 0 283 298 1 1
    MEFV RASGRP4 0 0 0 169 1 1
    MEFV CASP3 0 0 369 369 1 2
    MEFV MSR1 0 0 74 226 1 1
    MEFV ATG16L1 270 0 927 945 1 2
    MEFV PIK3CD 0 0 134 172 1 1
    MEFV FAM105A 0 0 95 155 1 1
    MEFV NOD2 0 0 768 782 1 1
    MEFV CIITA 0 0 652 686 1 1
    MEFV RIPK1 0 0 369 379 1 1
    MEFV MOK 0 0 73 189 1 1
    MEFV IL1RAP 0 0 325 325 1 1
    MEFV FCGR3B 0 0 90 206 1 1
    MEFV CTSG 0 0 155 186 1 1
    MEFV CCL3 0 0 217 254 1 1
    MEFV TRIM54 0 0 165 250 1 1
    MEFV ZNF263 0 0 456 476 1 1
    MEFV IL18RAP 0 0 207 254 1 1
    MEFV TCF23 0 0 77 234 1 1
    MEFV TRIM32 0 0 234 314 1 1
    MEFV MARCO 0 0 155 197 1 1
    MEFV IRAK4 0 0 394 417 1 1
    MEFV IL10 0 0 452 483 1 1
    MEFV PRPS1 0 0 388 388 1 1
    MEFV ARFGEF1 0 0 0 170 1 1
    MEFV TRIM45 0 0 75 167 1 1
    MEFV TRIM46 0 0 124 231 1 1
    MEFV AGO1 0 0 0 169 1 1
    MEFV GSDMC 0 0 141 194 1 1
    MEFV FBXL2 0 0 154 153 1 1
    MEFV NLRP6 0 0 770 784 1 1
    MEFV FPR1 0 0 124 243 1 1
    MEFV BST2 0 0 122 161 1 1
    MEFV HIST1H4K 0 0 53 164 1 1
    MEFV FCGR2A 0 0 108 185 1 1
    MEFV DOCK8 0 0 127 190 1 1
    MEFV CLEC4E 0 0 263 398 1 1
    MEFV ZNF200 0 0 630 652 1 1
    MEFV H2BFS 0 0 0 151 1 1
    MEFV DFNA5 0 0 400 400 1 1
    MEFV IFNB1 0 0 521 542 1 1
    MEFV NCL 0 0 46 251 1 1
    MEFV IL10RB 0 0 170 188 1 1
    MEFV IRF1 0 0 292 349 1 1
    MEFV COL4A6 0 0 397 396 1 1
    MEFV MAP1LC3B 0 0 451 522 1 2
    MEFV NCF2 0 0 150 223 1 1
    MEFV GBP3 0 0 143 239 1 1
    MEFV C3 0 0 167 186 1 1
    MEFV FN1 0 0 154 153 1 1
    MEFV ULK1 270 0 150 352 1 2
    MEFV SETD2 0 0 0 154 1 1
    MEFV PKN1 0 800 439 901 1 1
    MEFV ELANE 0 0 201 231 1 1
    MEFV IL1RL2 0 0 288 288 1 1
    MEFV HIST1H2BH 0 0 0 151 1 1
    MEFV CASP10 0 0 205 300 1 1
    MEFV MARCH7 0 0 225 242 1 1
    MEFV LILRB1 0 0 0 166 1 1
    MEFV BRCA1 0 0 184 184 1 1
    MEFV IFNA1 0 0 390 390 1 1
    MEFV IL15 0 0 150 168 1 1
    MEFV OR1F1 0 0 764 764 1 1
    MEFV UBE2H 0 0 0 154 1 1
    MEFV IL36G 0 0 91 157 1 1
    MEFV ACP5 0 0 52 172 1 1
    MEFV TRIM6-TRIM34 0 0 194 182 1 1
    MEFV APAF1 0 0 458 457 1 1
    MEFV JAK2 0 0 133 179 1 1
    MEFV NLRC5 0 0 595 604 1 1
    MEFV MICA 0 0 193 193 1 1
    MEFV TRIM8 0 0 162 320 1 1
    MEFV PTPN22 0 0 178 265 1 1
    MEFV TRIM16 0 0 374 187 1 2
    MEFV TP53 0 0 258 269 1 2
    MEFV DEFB103A 0 0 156 155 1 1
    MEFV CFLAR 0 0 218 287 1 1
    MEFV CARD9 0 0 391 404 1 1
    MEFV RPL36 0 0 0 161 1 1
    MEFV IRAK1 0 0 392 402 1 1
    MEFV PSTPIP2 0 0 505 815 1 1
    MEFV P2RX4 0 0 193 222 1 1
    MEFV ZBP1 0 0 340 590 1 1
    MEFV NLRP4 0 0 537 549 1 1
    MEFV MAP3K7 0 0 183 196 1 1
    MEFV HIST1H4F 0 0 53 164 1 1
    MEFV MARK4 0 0 150 168 1 1
    MEFV ADAR 0 0 137 151 1 1
    MEFV CD163 0 0 113 164 1 1
    MEFV TRIM59 0 0 151 209 1 1
    MEFV MTOR 0 0 164 177 1 2
    MEFV CXXC1 0 0 0 158 1 1
    MEFV NLRC3 0 0 565 597 1 1
    MEFV STAT1 0 0 310 325 1 1
    MEFV CTSL 0 0 262 262 1 1
    MEFV ENSG00000268500 0 0 0 154 1 1
    MEFV CXCL8 0 0 457 457 1 1
    MEFV CTNNB1 0 0 134 167 1 1
    MEFV IKBKE 0 0 193 273 1 1
    MEFV ERAP1 0 0 324 323 1 1
    MEFV LACC1 0 0 241 240 1 1
    MEFV STAT4 0 0 176 194 1 1
    MEFV TLR10 0 0 282 443 1 1
    MEFV TRIM25 0 0 391 234 1 1
    MEFV TRIM34 0 0 195 152 1 1
    MEFV RELA 0 0 454 454 1 1
    MEFV NFKB1 0 0 167 244 1 1
    MEFV GAPDH 0 0 285 313 1 2
    MEFV SPSB1 0 0 103 167 1 1
    MEFV PML 0 0 261 420 1 1
    MEFV HIST4H4 0 0 53 164 1 1
    MEFV ABL1 0 0 199 292 1 1
    MEFV OAS2 0 0 117 151 1 1
    MEFV TRIM9 0 0 129 218 1 1
    MEFV HCAR2 0 0 122 196 1 1
    MEFV GSDMD 0 0 710 744 1 1
    MEFV DHX9 0 0 208 280 1 1
    MEFV SPSB2 0 0 134 153 1 1
    MEFV MAP1LC3B2 0 0 0 164 1 2
    MEFV C5AR1 0 0 155 299 1 1
    MEFV IQGAP1 0 0 430 430 1 1
    MEFV HIST1H2BK 0 0 0 151 1 1
    MEFV PUM2 0 0 0 199 1 1
    MEFV MAST2 0 0 47 169 1 1
    MEFV UTP14C 0 0 0 155 1 1
    MEFV KCNK6 0 0 118 150 1 1
    MEFV CLEC6A 0 0 216 286 1 1
    MEFV NLRP8 0 0 630 638 1 1
    MEFV IL36RN 0 0 310 312 1 1
    MEFV LTA 0 0 112 174 1 1
    MEFV SOD1 0 0 67 169 1 1
    MEFV NLRP13 0 0 630 630 1 1
    MEFV ENSG00000173366 0 0 498 527 1 1
    MEFV TYK2 0 0 184 197 1 1
    MEFV FUT2 0 0 169 169 1 1
    MEFV FBL 0 0 0 187 1 1
    MEFV RNF165 0 0 82 253 1 1
    MEFV JUN 0 0 231 243 1 1
    MEFV DHX15 0 0 95 169 1 1
    MEFV TRIM38 0 0 266 166 1 1
    MEFV JAK3 0 0 108 226 1 1
    MEFV ZNF213 0 0 125 157 1 1
    MEFV AIF1 0 0 180 223 1 1
    MEFV NLRX1 0 0 559 564 1 1
    MEFV GBP7 0 0 143 200 1 1
    MEFV TLE6 0 0 155 238 1 1
    MEFV SELL 0 0 88 176 1 1
    MEFV MAPK3 0 0 139 158 1 2
    MEFV PSD4 0 0 0 200 1 1
    MEFV MMP9 0 0 161 179 1 1
    MEFV SQSTM1 0 0 375 390 1 2
    MEFV HSP90AA1 0 0 213 213 1 2
    MEFV IL21 0 0 0 398 1 1
    MEFV MBL2 0 0 150 164 1 1
    MEFV SP100 0 0 128 188 1 1
    MEFV CRP 0 0 556 556 1 1
    MEFV SMDT1 0 0 171 171 1 1
    MEFV LILRA6 0 0 0 179 1 1
    MEFV BCL10 0 0 284 284 1 1
    MEFV PTPRC 0 0 173 244 1 1
    MEFV MID1 0 0 401 231 1 1
    MEFV ICAM1 0 0 252 268 1 1
    MEFV CSF2RA 0 0 0 191 1 1
    MEFV DDX41 0 0 393 410 1 1
    MEFV HIST1H2BO 0 0 0 151 1 1
    MEFV AGER 0 0 283 282 1 1
    MEFV CD33 0 0 72 172 1 1
    MEFV MB21D1 0 0 647 660 1 1
    MEFV FBXO9 0 0 0 151 1 1
    MEFV ZNF205 0 0 723 733 1 1
    MEFV GLMN 0 0 91 187 1 1
    MEFV ARL6IP4 0 0 74 577 1 1
    MEFV TRADD 0 0 260 260 1 1
    MEFV SIGLEC9 0 0 0 169 1 1
    MEFV GBP1 0 0 118 217 1 1
    MEFV CD68 0 0 210 219 1 1
    MEFV ALB 0 0 283 282 1 1
    MEFV CCL2 0 0 371 382 1 2
    MEFV OTULIN 0 0 241 240 1 1
    MEFV CARD17 0 0 368 726 1 1
    MEFV TYROBP 0 0 134 194 1 1
    MEFV CASP7 0 0 297 297 1 1
    MEFV IL4 0 0 303 303 1 1
    MEFV TIGD7 0 0 218 218 1 1
    MEFV LGALS8 270 0 96 311 1 1
    MEFV CHD1 0 0 0 214 1 1
    MEFV BIRC3 0 0 134 238 1 1
    MEFV IL17F 0 0 134 193 1 1
    MEFV CYCS 0 0 261 261 1 1
    MEFV NWD2 0 0 167 167 1 1
    MEFV HIST2H2BF 0 0 0 150 1 1
    MEFV DHX36 0 0 316 350 1 1
    MEFV IL18BP 0 0 287 304 1 1
    MEFV PYHIN1 0 0 653 692 1 1
    MEFV TRAF6 0 0 407 407 1 2
    MEFV PCSK1 0 0 134 153 1 1
    MEFV PRTN3 0 0 310 335 1 1
    MEFV DICER1 0 0 72 197 1 1
    MEFV PRPS1L1 0 0 398 398 1 1
    MEFV PYDC1 0 0 586 155 1 1
    MEFV PPARA 0 0 125 157 1 1
    MEFV TRIM55 0 0 112 208 1 1
    MEFV CXCL9 0 0 155 192 1 1
    MEFV CENPL 0 0 73 174 1 1
    MEFV HSPB3 0 0 238 237 1 1
    MEFV CLEC12A 0 0 55 165 1 1
    MEFV CCR2 0 0 193 234 1 2
    MEFV DDX1 0 0 150 204 1 1
    MEFV TPM2 0 0 0 169 1 1
    MEFV IL1F10 0 0 195 239 1 1
    MEFV MBTPS2 0 0 326 340 1 1
    MEFV CCR1 0 0 124 180 1 1
    MEFV P2RX7 0 0 504 558 1 1
    MEFV MAPK8 0 0 145 163 1 2
    MEFV NANOS3 0 0 0 156 1 1
    MEFV KLRD1 0 0 45 169 1 1
    MEFV LILRB2 0 0 0 167 1 1
    MEFV CXCL3 0 0 123 157 1 1
    MEFV HIST1H4H 0 0 53 164 1 1
    MEFV IFNAR1 0 0 244 243 1 1
    MEFV LRRC34 0 0 82 187 1 1
    MEFV DEFB4A 0 0 173 173 1 1
    MEFV BTK 0 0 155 203 1 1
    MEFV SOCS1 0 0 108 194 1 1
    MEFV KHDC3L 0 0 248 259 1 1
    MEFV KLRC4 0 0 284 284 1 1
    MEFV GBP5 0 0 534 556 1 1
    MEFV UBAC2 0 0 134 156 1 1
    MEFV CASP2 0 0 324 323 1 1
    MEFV ZNF174 0 0 415 436 1 1
    MEFV TANK 0 0 244 243 1 1
    MEFV TIRAP 0 0 392 392 1 1
    MEFV DFNB59 0 0 181 181 1 1
    MEFV TRIM74 0 0 0 181 1 1
    MEFV IL23R 0 0 282 282 1 1
    MEFV DDX3X 0 0 134 228 1 1
    MEFV CD209 0 0 180 240 1 1
    MEFV FCAR 0 0 0 214 1 1
    MEFV HIST2H4B 0 0 53 164 1 1
    MEFV CARD18 0 0 415 414 1 1
    MEFV GALR1 0 0 54 223 1 1
    MEFV LST1 0 0 0 163 1 1
    MEFV LCP1 0 0 61 160 1 1
    MEFV TXN 0 0 285 318 1 1
    MEFV S100A10 0 0 0 183 1 1
    MEFV ENSG00000264813 0 0 134 188 1 1
    MEFV IFT43 0 0 201 201 1 1
    MEFV PRPS2 0 0 390 390 1 1
    MEFV YWHAQ 270 0 0 270 1 1
    MEFV IRAK2 0 0 323 334 1 1
    MEFV NCF1 0 0 202 292 1 1
    MEFV PTAFR 0 0 74 162 1 1
    MEFV SIGLEC10 0 0 0 182 1 1
    MEFV CD19 0 0 134 165 1 1
    MEFV UBE2I 0 0 45 354 1 1
    MEFV IRF8 0 0 215 260 1 1
    MEFV MPHOSPH8 0 0 0 157 1 1
    MEFV LRBA 0 0 122 160 1 1
    MEFV CDC42 0 0 142 171 1 1
    MEFV APOE 0 0 181 181 1 1
    MEFV BBOX1 0 0 678 678 1 1
    MEFV MIF 0 0 143 161 1 1
    MEFV RSAD2 0 0 123 173 1 1
    MEFV TLR3 0 0 490 497 1 1
    MEFV TRIM28 0 0 203 257 1 2
    MEFV CD180 0 0 107 182 1 1
    MEFV TXNDC9 0 0 575 625 1 1
    MEFV LILRA2 0 0 0 232 1 1
    MEFV COG5 192 0 48 197 1 1
    MEFV RAC2 0 0 134 169 1 1
    MEFV GIMAP2 0 0 155 195 1 1
    MEFV HIST1H2BJ 0 0 0 161 1 1
    MEFV FOXP3 0 0 172 184 1 1
    MEFV HIST1H4D 0 0 53 164 1 1
    MEFV POP4 0 0 150 303 1 1
    MEFV CLEC5A 0 0 108 184 1 1
    MEFV TBK1 0 0 494 513 1 2
    MEFV RIPK3 0 0 391 414 1 1
    MEFV PRKCD 0 0 139 206 1 2
    MEFV TEP1 0 0 387 395 1 1
    MEFV TRIM29 0 0 180 192 1 1
    MEFV FAS 0 0 162 193 1 2
    MEFV VCAM1 0 0 170 188 1 1
    MEFV MBTPS1 0 0 305 320 1 1
    MEFV WDR20 0 0 0 157 1 1
    MEFV HIST1H4C 0 0 53 164 1 1
    MEFV CSF2 0 0 263 263 1 1
    MEFV DROSHA 0 0 0 177 1 1
    MEFV NOX4 0 0 167 173 1 1
    MEFV NLRC4 0 0 857 883 1 2
    MEFV DDX56 0 0 150 182 1 1
    MEFV CYLD 0 0 171 195 1 1
    MEFV SSRP1 0 0 0 196 1 1
    MEFV PHGDH 0 0 140 162 1 1
    MEFV GPT 0 0 166 184 1 1
    MEFV SPTA1 0 0 122 322 1 1
    MEFV AGO3 0 0 0 194 1 1
    MEFV CARD6 0 0 112 208 1 1
    MEFV TPM3 0 0 0 169 1 1
    MEFV MID2 0 0 508 258 1 1
    MEFV NANOS2 0 0 0 156 1 1
    MEFV NANOS1 0 0 0 156 1 1
    MEFV SOD2 0 0 67 163 1 1
    MEFV IRAK3 0 0 202 260 1 1
    MEFV SIGIRR 0 0 194 194 1 1
    MEFV IRG1 0 0 42 228 1 1
    MEFV FCN1 0 0 0 214 1 1
    MEFV WAS 0 0 181 218 1 1
    MEFV CD86 0 0 180 298 1 1
    MEFV NOD1 0 0 683 692 1 1
    MEFV SHARPIN 0 0 163 187 1 1
    MEFV CCL7 0 0 141 157 1 1
    MEFV TRAF3 0 0 330 330 1 2
    MEFV TLR2 0 0 556 594 1 1
    MEFV ATG12 0 0 181 181 1 2
    MEFV PRKCQ 0 0 51 166 1 2
    MEFV CD28 0 0 125 160 1 1
    MEFV TRIM56 0 0 315 355 1 1
    MEFV IL33 0 0 426 438 1 1
    MEFV CXCL1 0 0 278 306 1 1
    MEFV TRPM2 0 0 154 208 1 1
    MEFV HCK 0 0 454 508 1 1
    MEFV CSF1 0 0 212 226 1 1
    MEFV ZNF75A 0 0 179 209 1 1
    MEFV ITGAX 0 0 171 286 1 1
    MEFV SLC11A1 0 0 95 289 1 1
    MEFV PTPN12 0 0 438 558 1 1
    MEFV CASP4 0 0 340 449 1 2
    MEFV HIST2H4A 0 0 53 164 1 1
    MEFV CHUK 0 0 324 335 1 1
    MEFV NLRP11 0 0 663 668 1 1
    MEFV S100A12 0 0 224 321 1 1
    MEFV ZNF433 0 0 133 165 1 1
    MEFV SAMHD1 0 0 156 195 1 1
    MEFV CXCL2 0 0 193 224 1 1
    MEFV FMN1 0 0 0 167 1 1
    MEFV CCL20 0 0 150 173 1 1
    MEFV ACTG1 0 0 74 161 1 1
    MEFV TRAT1 0 0 560 560 1 1
    MEFV DHX8 0 0 0 157 1 1
    MEFV ATG7 0 0 150 182 1 2
    MEFV FFAR4 0 0 177 201 1 1
    MEFV CASP5 0 0 641 718 1 1
    MEFV NEK7 0 0 519 556 1 1
    MEFV TREML4 0 0 0 167 1 1
    MEFV LRR1 0 0 155 168 1 1
    MEFV VEGFA 0 0 170 169 1 1
    MEFV IRF4 0 0 134 221 1 1
    MEFV GABARAP 270 0 150 494 1 2
    MEFV HIST1H4A 0 0 53 164 1 1
    MEFV WDR1 0 0 293 325 1 1
    MEFV CSF3R 0 0 0 175 1 1
    MEFV NFKBIA 0 0 720 734 1 1
    MEFV HFE 0 0 72 170 1 1
    MEFV SYK 0 0 327 376 1 1
    MEFV LYN 0 0 124 189 1 1
    MEFV IRF5 0 0 202 234 1 1
    MEFV HMGB1 0 0 458 469 1 2
    MEFV HMGN5 0 0 0 261 1 1
    MEFV ITGAM 0 0 234 287 1 1
    MEFV RNH1 0 0 443 449 1 1
    MEFV CR1 0 0 0 154 1 1
    MEFV SIRT1 0 0 156 191 1 2
    MEFV MCL1 0 0 456 469 1 2
    MEFV CTSB 0 0 501 501 1 2
    MEFV TP53BP1 0 0 150 157 1 1
    MEFV SPI1 0 0 177 238 1 1
    MEFV PTPN1 0 0 81 234 1 1
    MEFV PUM1 0 0 0 199 1 1
    MEFV TLR8 0 0 395 478 1 1
    MEFV ATG5 0 0 252 252 1 2
    MEFV NLRP14 0 0 630 643 1 1
    MEFV MVK 0 0 710 710 1 1
    MEFV SERPINB9 0 0 204 220 1 1
    MEFV ISG15 0 0 180 238 1 1
    MEFV PIAS3 0 0 0 210 1 1
    MEFV MYO1F 0 0 46 190 1 1
    MEFV CXCR5 0 0 44 636 1 1
    MEFV CASR 0 0 150 168 1 1
    MEFV IKBKG 0 0 370 370 1 1
    MEFV CCR7 0 0 75 156 1 1
    MEFV TBX21 0 0 103 206 1 1
    MEFV RPS6KA1 0 800 456 888 1 1
    MEFV SOD3 0 0 54 157 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0003779 Molecular Function actin binding enables IDA
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0061630 Molecular Function ubiquitin protein ligase activity enables IBA
    GO:0008270 Molecular Function zinc ion binding enables NAS
    GO:0006954 Biological Process inflammatory response involved_in IDA
    GO:0045087 Biological Process innate immune response involved_in IBA
    GO:1900226 Biological Process negative regulation of NLRP3 inflammasome complex assembly involved_in IMP
    GO:1900016 Biological Process negative regulation of cytokine production involved in inflammatory response involved_in IMP
    GO:0050728 Biological Process negative regulation of inflammatory response involved_in IMP
    GO:0032691 Biological Process negative regulation of interleukin-1 beta production involved_in IMP
    GO:0032695 Biological Process negative regulation of interleukin-12 production involved_in IMP
    GO:0071641 Biological Process negative regulation of macrophage inflammatory protein 1 alpha production involved_in IMP
    GO:0002221 Biological Process pattern recognition receptor signaling pathway involved_in NAS
    GO:0010508 Biological Process positive regulation of autophagy involved_in IDA
    GO:0050729 Biological Process positive regulation of inflammatory response involved_in ISO
    GO:0032731 Biological Process positive regulation of interleukin-1 beta production involved_in IDA
    GO:1904270 Biological Process pyroptosome complex assembly involved_in IDA
    GO:0070269 Biological Process pyroptotic inflammatory response involved_in NAS
    GO:0010468 Biological Process regulation of gene expression involved_in IBA
    GO:0032651 Biological Process regulation of interleukin-1 beta production involved_in IMP
    GO:0034341 Biological Process response to type II interferon involved_in IDA
    GO:0005776 Cellular Component autophagosome located_in IEA
    GO:0061702 Cellular Component canonical inflammasome complex part_of IPI
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0031410 Cellular Component cytoplasmic vesicle located_in IEA
    GO:0005829 Cellular Component cytosol is_active_in IBA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0030027 Cellular Component lamellipodium located_in IEA
    GO:0005874 Cellular Component microtubule located_in NAS
    GO:0005875 Cellular Component microtubule associated complex part_of IDA
    GO:0005654 Cellular Component nucleoplasm is_active_in IBA
    GO:0005634 Cellular Component nucleus located_in IDA
    GO:0005886 Cellular Component plasma membrane located_in IDA
    GO:0001726 Cellular Component ruffle located_in IEA
    Pathways
    Name DB ID
    Nucleotide-binding oligomerization domain (NOD) pathway (WP1433) WikiPathways WP1433_r122867
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001198536 2 mRNA transcript variant 2 NC_000016 Reference
    NM_000243 3 mRNA transcript variant 1 NC_000016 Reference