ARSB

arylsulfatase B
General Information
Name arylsulfatase B
Alias
  • arylsulfatase B
  • N-acetylgalactosamine-4-sulfatase
Synonyms ASB G4S MPS6
Gene_family Sulfatases
organism Homo sapiens
entrez_id 411
location 5q14.1
transcript_count 10
exon_count 17
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
      Stringdb Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family
      nextProt Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    ARSB BioGRID CNPY3 GeneID BioGRID Proximity Label-MS
    ARSB BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID STK3 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID FBXO45 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID LCN6 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID LYPD2 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID LLCFC1 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID CST9L GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID C1orf54 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID SLURP1 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID SUSD4 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID NAAA GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID FBXO2 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID ERP29 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID EDDM3A GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID INSL5 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID GGH GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID CCL3L1 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID CCL3 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID RLN1 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID PTPRK GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID PLAUR GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID PDGFRA GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID SCGB2A2 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID MFAP4 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID IGF2R GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID DEFA1 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID CST5 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID CLGN GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID AVP GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID DEFB109B GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID DEFB135 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID BRD2 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID VIRMA GeneID BioGRID Affinity Capture-RNA
    ARSB BioGRID SIAE GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID ESR1 GeneID BioGRID Affinity Capture-MS
    ARSB BioGRID ELAVL1 GeneID BioGRID Affinity Capture-RNA
    StringDB
    A B experiments database textmining combined score hadb nhadb
    ARSB DEFA1 184 0 0 183 1 1
    ARSB CPVL 0 0 0 187 1 1
    ARSB ATP6V0D1 0 0 0 189 1 1
    ARSB TMEM230 0 0 0 175 1 1
    ARSB AOX1 0 0 0 271 1 1
    ARSB SUSD2 0 0 170 169 1 1
    ARSB MCOLN1 0 0 243 359 1 1
    ARSB GLB1L 0 0 0 157 1 1
    ARSB FREM2 0 0 0 162 1 1
    ARSB CHIT1 0 0 260 269 1 1
    ARSB CHST11 0 0 456 510 1 1
    ARSB CLN5 0 0 134 202 1 1
    ARSB GBA 0 0 255 383 1 1
    ARSB MKNK1 0 0 0 189 1 1
    ARSB EPDR1 0 0 298 459 1 1
    ARSB SUMF1 0 900 623 983 1 1
    ARSB WNT9A 0 0 252 252 1 1
    ARSB CTSA 0 0 210 333 1 1
    ARSB PNLIP 0 0 166 226 1 1
    ARSB FPGS 0 0 0 308 1 1
    ARSB FARSB 0 0 322 745 1 1
    ARSB HEXB 0 0 406 466 1 1
    ARSB CSF3 0 0 0 254 1 1
    ARSB ENSG00000260170 0 0 0 208 1 1
    ARSB PPT2 0 0 181 328 1 1
    ARSB PEBP4 0 0 203 214 1 1
    ARSB SPAM1 0 900 103 916 1 1
    ARSB CHSY3 0 0 261 261 1 1
    ARSB DECR1 0 0 136 175 1 1
    ARSB IDUA 0 900 740 973 1 1
    ARSB LAMP1 0 0 124 202 1 2
    ARSB GAA 0 0 171 320 1 2
    ARSB CFTR 0 0 195 205 1 1
    ARSB LIPA 0 0 217 217 1 1
    ARSB CFDP1 0 0 167 397 1 1
    ARSB DCN 0 0 202 231 1 2
    ARSB PRDM10 0 0 123 167 1 1
    ARSB ARSD 0 300 0 496 1 1
    ARSB SLC38A6 0 0 0 256 1 1
    ARSB LACRT 0 0 181 324 1 1
    ARSB TMEM134 0 0 122 244 1 1
    ARSB MKNK2 0 0 0 189 1 1
    ARSB GPNMB 0 0 243 242 1 1
    ARSB AOC1 0 0 290 304 1 1
    ARSB NCAN 0 0 295 345 1 1
    ARSB EAPP 0 0 94 190 1 1
    ARSB CPO 0 0 181 307 1 1
    ARSB WIPI2 0 0 0 152 1 2
    ARSB GALNS 0 0 845 377 1 1
    ARSB HYAL4 0 900 85 935 1 1
    ARSB HS6ST1 0 0 122 188 1 1
    ARSB NPC1 0 0 154 206 1 2
    ARSB ENSG00000261832 0 0 103 240 1 1
    ARSB AP5M1 0 0 70 444 1 1
    ARSB CPQ 0 0 134 262 1 1
    ARSB EPB41L2 0 0 155 244 1 1
    ARSB XDH 0 0 0 603 1 1
    ARSB LINS 0 0 100 181 1 1
    ARSB FA2H 0 0 0 189 1 1
    ARSB LGMN 0 0 170 169 1 1
    ARSB MAN1A1 0 0 0 161 1 1
    ARSB RAB11FIP5 0 0 0 398 1 1
    ARSB TDRD7 0 0 0 232 1 1
    ARSB UBE2H 0 0 0 254 1 1
    ARSB PLBD2 0 0 251 413 1 1
    ARSB GNS 0 0 503 455 1 1
    ARSB HYAL2 0 900 81 924 1 1
    ARSB MAP6 0 0 108 172 1 1
    ARSB ACE2 0 0 0 197 1 1
    ARSB ALPI 0 0 134 155 1 1
    ARSB AGPAT5 0 0 0 252 1 1
    ARSB CHST15 0 0 367 433 1 1
    ARSB SVOPL 0 0 81 151 1 1
    ARSB STK19 0 0 54 217 1 1
    ARSB UHRF1BP1L 0 0 111 215 1 1
    ARSB CRISPLD2 0 0 134 599 1 1
    ARSB BHMT 0 0 0 303 1 1
    ARSB VPS13D 0 0 0 250 1 1
    ARSB DYM 0 0 171 171 1 1
    ARSB ERP29 129 0 0 180 1 1
    ARSB HIRA 0 0 70 212 1 1
    ARSB FBXO42 0 0 94 150 1 1
    ARSB DMGDH 0 0 167 606 1 1
    ARSB ARHGAP20 0 0 0 187 1 1
    ARSB SLC31A2 0 0 0 261 1 1
    ARSB TGFBI 0 0 90 246 1 1
    ARSB ABAT 0 0 66 336 1 1
    ARSB FUCA1 0 0 213 238 1 1
    ARSB MGAM 0 0 391 432 1 1
    ARSB SQRDL 0 0 0 208 1 1
    ARSB PSAP 0 0 142 243 1 1
    ARSB CHPF 0 0 214 314 1 1
    ARSB KAL1 0 0 0 155 1 1
    ARSB LHFPL2 0 0 263 354 1 1
    ARSB SIAE 499 0 290 655 1 1
    ARSB DHX35 0 0 218 218 1 1
    ARSB PRCP 0 0 230 438 1 1
    ARSB CST6 0 0 157 156 1 1
    ARSB CLUAP1 0 0 0 214 1 1
    ARSB PDS5B 0 0 0 553 1 1
    ARSB LGALS3 0 0 369 382 1 1
    ARSB AP5B1 0 0 82 223 1 1
    ARSB RIC3 0 0 0 189 1 1
    ARSB HEXA 0 0 377 440 1 1
    ARSB CPA2 0 0 154 192 1 1
    ARSB NAGLU 0 0 563 572 1 1
    ARSB SCPEP1 0 0 0 187 1 1
    ARSB DPYS 0 0 0 252 1 1
    ARSB DCXR 0 0 0 157 1 1
    ARSB SNRPA 0 0 0 190 1 1
    ARSB B4GALNT3 0 0 81 245 1 1
    ARSB PLOD3 0 0 141 236 1 1
    ARSB KLHL31 0 0 0 256 1 1
    ARSB ACAN 0 0 142 165 1 1
    ARSB PREPL 0 0 0 272 1 1
    ARSB ARSH 0 300 417 564 1 1
    ARSB C4A 0 0 344 343 1 1
    ARSB NAT10 0 0 0 254 1 1
    ARSB BBOX1 0 0 0 150 1 1
    ARSB GLA 0 0 425 424 1 1
    ARSB ATP6V0E2 0 0 0 256 1 1
    ARSB CLCN7 0 0 74 280 1 1
    ARSB IGSF23 0 0 150 208 1 1
    ARSB PURG 0 0 140 172 1 1
    ARSB AUTS2 0 0 0 181 1 1
    ARSB NKX1-2 0 0 233 232 1 1
    ARSB HYAL1 0 900 113 912 1 1
    ARSB OSTM1 0 0 57 153 1 1
    ARSB CTSL 0 0 294 331 1 1
    ARSB SULF2 0 0 340 468 1 1
    ARSB KIAA1429 270 0 0 270 1 1
    ARSB CXCL8 0 0 150 157 1 1
    ARSB CLN3 0 0 157 286 1 2
    ARSB OR1J2 0 0 234 234 1 1
    ARSB BTD 0 0 241 298 1 1
    ARSB PTPRQ 0 0 0 190 1 1
    ARSB H6PD 0 0 0 170 1 1
    ARSB ZNF543 0 0 181 181 1 1
    ARSB OR7G3 0 0 157 245 1 1
    ARSB VPS13C 0 0 48 308 1 1
    ARSB ARHGAP18 0 0 0 161 1 1
    ARSB POFUT1 0 0 0 191 1 1
    ARSB CTSZ 0 0 202 428 1 1
    ARSB DPP7 0 0 244 367 1 1
    ARSB SPON2 0 0 108 157 1 1
    ARSB RNASE2 0 0 134 159 1 1
    ARSB ASAH1 0 0 123 261 1 1
    ARSB VPS13A 0 0 0 303 1 1
    ARSB STS 0 300 720 598 1 1
    ARSB SULT1A3 0 0 150 151 1 1
    ARSB REN 0 0 0 177 1 1
    ARSB SLC25A40 0 0 60 218 1 1
    ARSB NEU1 0 0 96 198 1 1
    ARSB ACE 0 0 0 187 1 1
    ARSB TMLHE 0 0 0 150 1 1
    ARSB IMMP2L 0 0 151 150 1 1
    ARSB AGA 0 0 141 180 1 1
    ARSB SPP1 0 0 49 150 1 1
    ARSB ORC4 0 0 141 233 1 1
    ARSB GUSB 0 0 470 549 1 1
    ARSB SUSD4 213 0 0 213 1 1
    ARSB ENSG00000269590 0 0 0 337 1 1
    ARSB GPATCH2L 0 0 167 188 1 1
    ARSB CKB 0 0 108 182 1 1
    ARSB BDH1 0 0 0 254 1 1
    ARSB ARSE 0 300 0 490 1 1
    ARSB LENG9 0 0 330 330 1 1
    ARSB TMEM161B 0 0 316 434 1 1
    ARSB TMEM129 0 0 218 339 1 1
    ARSB IDS 0 0 687 471 1 1
    ARSB SMPD1 0 0 265 374 1 1
    ARSB BCL10 0 0 112 167 1 1
    ARSB PRG4 0 0 95 151 1 1
    ARSB PTPRB 0 0 0 258 1 1
    ARSB GLB1L2 0 0 0 157 1 1
    ARSB SULF1 0 0 341 448 1 1
    ARSB PTPN11 0 0 219 219 1 1
    ARSB SOD1 0 0 74 223 1 1
    ARSB IRG1 0 0 0 179 1 1
    ARSB LAMP2 0 0 180 234 1 2
    ARSB HYAL3 0 900 0 906 1 1
    ARSB SUMF2 0 900 94 957 1 1
    ARSB MAN2B1 0 0 247 479 1 1
    ARSB CPZ 0 0 213 213 1 1
    ARSB RNASE3 0 0 298 298 1 1
    ARSB GALNT1 0 0 0 187 1 1
    ARSB CBLN1 0 0 123 201 1 1
    ARSB ARSA 0 800 801 883 1 2
    ARSB PALMD 0 0 0 207 1 1
    ARSB SLC36A2 0 0 151 150 1 1
    ARSB CHST12 0 0 324 355 1 1
    ARSB PLA2G15 0 0 97 231 1 1
    ARSB CHST3 0 0 188 681 1 1
    ARSB GPR135 0 0 245 296 1 1
    ARSB SLC35B2 0 0 186 281 1 1
    ARSB GLB1L3 0 0 0 157 1 1
    ARSB SCAMP1 0 0 155 214 1 1
    ARSB TOLLIP 0 0 150 302 1 1
    ARSB ALPPL2 0 0 141 162 1 1
    ARSB MANBA 0 0 113 390 1 1
    ARSB SGSH 0 0 638 430 1 1
    ARSB ATP6V0E1 0 0 0 208 1 1
    ARSB SERPINA7 0 0 193 243 1 1
    ARSB ARSI 0 300 289 326 1 1
    ARSB SDC1 0 0 181 232 1 1
    ARSB NPC2 0 0 186 217 1 1
    ARSB BAG5 0 0 52 267 1 1
    ARSB MAN2A2 0 0 0 328 1 1
    ARSB ACAD11 0 0 0 183 1 1
    ARSB CSPG4 0 0 204 206 1 1
    ARSB MAN2A1 0 0 0 328 1 1
    ARSB ACSF2 0 0 0 256 1 1
    ARSB ASF1B 0 0 120 209 1 1
    ARSB SI 0 0 387 428 1 1
    ARSB TPP1 0 0 392 430 1 1
    ARSB CLCN6 0 0 0 189 1 1
    ARSB NAAA 312 0 123 464 1 1
    ARSB MYLIP 0 0 113 583 1 1
    ARSB UBA6 0 0 138 227 1 1
    ARSB PAPSS2 0 0 227 311 1 1
    ARSB KCNJ16 0 0 0 188 1 1
    ARSB PRKD1 0 0 0 213 1 1
    ARSB PPT1 0 0 216 353 1 1
    ARSB ARSF 0 300 0 406 1 1
    ARSB ENSG00000241489 0 0 0 499 1 1
    ARSB B3GAT2 0 0 0 307 1 1
    ARSB PLAUR 220 0 0 220 1 1
    ARSB ACAD10 0 0 0 235 1 1
    ARSB PTPRK 200 0 0 200 1 1
    ARSB ARHGAP28 0 0 0 263 1 1
    ARSB ARSK 0 300 339 768 1 1
    ARSB HGSNAT 0 0 231 351 1 1
    ARSB CTSB 0 0 150 294 1 2
    ARSB TINAG 0 0 88 184 1 1
    ARSB PTPRS 0 0 142 603 1 1
    ARSB CTSK 0 0 145 266 1 1
    ARSB MAN2B2 0 0 0 256 1 1
    ARSB VCAN 0 0 458 471 1 1
    ARSB OPTN 0 0 60 206 1 2
    ARSB ACP2 0 0 235 235 1 1
    ARSB DLX1 0 0 0 207 1 1
    ARSB GNPTG 0 0 267 281 1 1
    ARSB POU2F2 0 0 112 152 1 1
    ARSB MUT 0 0 721 721 1 1
    ARSB ATP6V0D2 0 0 0 189 1 1
    ARSB MIPEP 0 0 0 527 1 1
    ARSB GNPTAB 0 0 137 287 1 1
    ARSB GALNT13 0 0 0 187 1 1
    ARSB TCHHL1 0 0 112 167 1 1
    ARSB CXorf36 0 0 0 206 1 1
    ARSB EPX 0 0 324 323 1 1
    ARSB ADI1 0 0 0 161 1 1
    ARSB GALC 0 0 360 360 1 1
    ARSB ZSCAN23 0 0 127 181 1 1
    ARSB MPG 0 0 139 509 1 1
    ARSB CHSY1 0 0 154 153 1 1
    ARSB ACAA1 0 0 0 263 1 1
    ARSB GLB1 0 0 456 521 1 1
    ARSB UPP2 0 0 0 209 1 1
    ARSB HEATR1 0 0 193 193 1 1
    ARSB COL20A1 0 0 0 246 1 1
    ARSB CTSD 0 0 271 278 1 2
    ARSB M6PR 0 0 451 451 1 1
    ARSB DIRC3 0 0 212 212 1 1
    ARSB ENG 0 0 44 191 1 1
    ARSB G6PD 0 0 0 154 1 1
    ARSB LCAT 0 0 0 277 1 1
    ARSB ARSJ 0 300 231 324 1 1
    ARSB SLBP 0 0 97 159 1 1
    ARSB GGH 0 0 103 159 1 1
    ARSB PTRF 0 0 0 339 1 1
    ARSB RIMS1 0 0 0 239 1 1
    ARSB PLD3 0 0 118 202 1 1
    ARSB ARSG 0 800 339 879 1 1
    ARSB UBA52 0 0 128 238 1 1
    ARSB PAPSS1 0 0 170 322 1 1
    ARSB MGEA5 0 0 725 725 1 1
    ARSB CSGALNACT1 0 0 150 244 1 1
    ARSB RIMS2 0 0 0 527 1 1
    ARSB MAEA 0 0 141 278 1 1
    ARSB TXN2 0 0 0 235 1 1
    ARSB CTNS 0 0 96 193 1 1
    ARSB UVSSA 0 0 170 169 1 1
    ARSB KNG1 0 0 152 151 1 1
    ARSB ALB 0 0 150 203 1 1
    ARSB WIPI1 0 0 0 152 1 2
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0003943 Molecular Function N-acetylgalactosamine-4-sulfatase activity enables IDA
    GO:0004065 Molecular Function arylsulfatase activity enables TAS
    GO:0046872 Molecular Function metal ion binding enables IEA
    GO:0006914 Biological Process autophagy involved_in IEA
    GO:0061580 Biological Process colon epithelial cell migration involved_in IMP
    GO:0007041 Biological Process lysosomal transport involved_in TAS
    GO:0007040 Biological Process lysosome organization involved_in TAS
    GO:0010976 Biological Process positive regulation of neuron projection development involved_in ISS
    GO:0010632 Biological Process regulation of epithelial cell migration involved_in IMP
    GO:0043627 Biological Process response to estrogen involved_in IEA
    GO:0051597 Biological Process response to methylmercury involved_in IEA
    GO:0007584 Biological Process response to nutrient involved_in IEA
    GO:0009268 Biological Process response to pH involved_in IEA
    GO:0035578 Cellular Component azurophil granule lumen located_in TAS
    GO:0009986 Cellular Component cell surface located_in ISS
    GO:0005788 Cellular Component endoplasmic reticulum lumen located_in TAS
    GO:0070062 Cellular Component extracellular exosome located_in HDA
    GO:0005576 Cellular Component extracellular region located_in TAS
    GO:1904813 Cellular Component ficolin-1-rich granule lumen located_in TAS
    GO:0043202 Cellular Component lysosomal lumen located_in TAS
    GO:0005764 Cellular Component lysosome located_in TAS
    Pathways
    Name DB ID
    Metabolism Reactome R-HSA-1430728
    Glycosaminoglycan metabolism Reactome R-HSA-1630316
    Gamma carboxylation, hypusine formation and arylsulfatase activation Reactome R-HSA-163841
    Disease Reactome R-HSA-1643685
    Glycosphingolipid metabolism Reactome R-HSA-1660662
    The activation of arylsulfatases Reactome R-HSA-1663150
    Innate Immune System Reactome R-HSA-168249
    Immune System Reactome R-HSA-168256
    Chondroitin sulfate/dermatan sulfate metabolism Reactome R-HSA-1793185
    CS/DS degradation Reactome R-HSA-2024101
    Mucopolysaccharidoses Reactome R-HSA-2206281
    MPS VI - Maroteaux-Lamy syndrome Reactome R-HSA-2206285
    Metabolism of proteins Reactome R-HSA-392499
    Sphingolipid metabolism Reactome R-HSA-428157
    Metabolism of lipids Reactome R-HSA-556833
    Diseases of carbohydrate metabolism Reactome R-HSA-5663084
    Diseases of metabolism Reactome R-HSA-5668914
    Post-translational protein modification Reactome R-HSA-597592
    Neutrophil degranulation Reactome R-HSA-6798695
    Metabolism of carbohydrates Reactome R-HSA-71387
    Glycosaminoglycan degradation (WP4815) WikiPathways WP4815_r110276
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XR_001742066 3 miscRNA transcript variant X5 NC_000005 Reference
    XR_001742065 3 miscRNA transcript variant X3 NC_000005 Reference
    XM_011543390 2 mRNA transcript variant X1 NC_000005 Reference
    NM_000046 5 mRNA transcript variant 1 NC_000005 Reference
    NM_198709 3 mRNA transcript variant 2 NC_000005 Reference
    XM_017009471 3 mRNA transcript variant X2 NC_000005 Reference
    XM_011543392 4 mRNA transcript variant X6 NC_000005 Reference
    XM_011543391 4 mRNA transcript variant X4 NC_000005 Reference
    XM_011543393 3 mRNA transcript variant X7 NC_000005 Reference
    XM_047417180 1 mRNA transcript variant X8 NC_000005 Reference