MALAT1

metastasis associated lung adenocarcinoma transcript 1
General Information
Name metastasis associated lung adenocarcinoma transcript 1
Alias
  • hepcarcin
  • long intergenic non-protein coding RNA 47
  • metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
  • nuclear enriched abundant transcript 2
  • nuclear paraspeckle assembly transcript 2 (non-protein coding)
Synonyms PRO1073 MALAT-1 NCRNA00047 HCN NEAT2 LINC00047 mascRNA PRO2853
Gene_family Long non-coding RNAs with non-systematic symbols
organism Homo sapiens
entrez_id 378938
location 11q13.1
transcript_count 3
exon_count 3
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015]
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    MALAT1 BioGRID KHSRP GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    MALAT1 BioGRID EHMT1 GeneID BioGRID Co-localization
    MALAT1 BioGRID RPS6 GeneID BioGRID Affinity Capture-RNA
    MALAT1 BioGRID HNRNPD GeneID BioGRID Affinity Capture-RNA
    MALAT1 BioGRID ILF3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-RNA
    MALAT1 BioGRID HNRNPUL2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID HNRNPA3 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID SERPINB12 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID H2BC12 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID H2AC12 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID LAS1L GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID TRIM56 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID FIP1L1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID POF1B GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID NOC4L GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID DDX54 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID MRPL38 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID MRPS9 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PARP12 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID TFB2M GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID MRPS35 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID CCAR2 GeneID BioGRID Affinity Capture-MS; Protein-RNA; Reconstituted Complex
    MALAT1 BioGRID MRPS22 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID MCCC1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PRPF40A GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID STRBP GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID WDR33 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PTCD3 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ANKHD1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID DDX56 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID RBM47 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID CPSF2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ZFR GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID NOP58 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID MRPL37 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID NSDHL GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID CPSF1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID RBMX GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID AP3M1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PRPF6 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID MTCH2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID CASP14 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID SF3B1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID SF3B3 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID RRP12 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID FAM120A GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID NUP205 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID MRPS27 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID COPG1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID XRN2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID U2AF2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID HNRNPA0 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID SF3A3 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID CLPX GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID KHDRBS1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID IGF2BP2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID AHSA1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PRPF8 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID TRIM38 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID CD2BP2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID RACK1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID SF3A1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID HNRNPR GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID RCL1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID TRIM28 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID FARSB GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID MATR3 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID NUP93 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID RBM39 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID DDX23 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID FIBP GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID FUBP3 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID RTCA GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID H4C1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID SF3A2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ALDH5A1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID DAP3 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID UBC GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID U2AF1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID TXN GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID TSPYL1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID TGM3 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PRDX2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID STAU1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID RO60 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID TRA2B GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID SRSF7 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID RPL5 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ABCD3 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PURB GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PURA GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PTBP1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PSMC5 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PSMC4 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PSMC3 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID POLR2C GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID POLR2A GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PCCB GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PCCA GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID PRDX1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID NDUFS1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID HNRNPM GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID MCM7 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID LTF GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ILF2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID HNRNPH1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-RNA
    MALAT1 BioGRID HNRNPF GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID HNRNPC GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID HNRNPAB GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID HNRNPA2B1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID HADH GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID SFN GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID GLO1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID GAPDH GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID G6PD GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID FARSA GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ETFA GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ELAVL1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID DKC1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID DHX9 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID DBT GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID CAPN2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID BLMH GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ATP5F1A GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ASS1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ARG1 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ANXA2P2 GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID AHSG GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID ADAR GeneID BioGRID Affinity Capture-MS
    MALAT1 BioGRID FBXW7 GeneID BioGRID Protein-RNA
    MALAT1 BioGRID LIG3 GeneID BioGRID Protein-RNA
    MALAT1 BioGRID HMGB1 GeneID BioGRID Two-hybrid
    MALAT1 BioGRID PARP1 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    MALAT1 BioGRID RUNX3 GeneID BioGRID Affinity Capture-RNA
    MALAT1 BioGRID TRIM25 GeneID BioGRID Affinity Capture-RNA
    MALAT1 BioGRID AGO2 GeneID BioGRID Affinity Capture-RNA
    StringDB
    A B experiments database textmining combined score hadb nhadb
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0140463 Molecular Function chromatin-protein adaptor activity enables IDA
    GO:0140869 Molecular Function miRNA inhibitor activity via base-pairing enables IDA
    GO:0071456 Biological Process cellular response to hypoxia involved_in IMP
    GO:0006325 Biological Process chromatin organization involved_in IEA
    GO:0000512 Biological Process lncRNA-mediated post-transcriptional gene silencing involved_in IDA
    GO:0110024 Biological Process positive regulation of cardiac muscle myoblast proliferation involved_in IMP
    GO:2000147 Biological Process positive regulation of cell motility involved_in IEA
    GO:2000627 Biological Process positive regulation of miRNA catabolic process involved_in IDA
    GO:0005634 Cellular Component nucleus located_in IDA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_144567 1 ncRNA transcript variant 2 NC_000011 Reference
    NR_144568 1 ncRNA transcript variant 3 NC_000011 Reference
    NR_002819 5 ncRNA transcript variant 1 NC_000011 Reference