IRGM

immunity related GTPase M
General Information
Name immunity related GTPase M
Alias
  • immunity-related GTPase family M protein
  • LPS-stimulated RAW 264.7 macrophage protein 47 homolog
  • LRG-47-like protein
  • immunity-related GTPase family, M1
  • interferon-inducible protein 1
Synonyms LRG47 LRG-47 IFI1 IRGM1
Gene_family None
organism Homo sapiens
entrez_id 345611
location 5q33.1
transcript_count 3
exon_count 5
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
      Stringdb Immunity-related GTPase family M protein; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family
      nextProt Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate pro-inflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    IRGM BioGRID CGAS GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    IRGM BioGRID NLRP3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    IRGM BioGRID NOD2 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    IRGM BioGRID PYCARD GeneID BioGRID Affinity Capture-Western
    IRGM BioGRID RIGI GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    IRGM BioGRID NOD1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    IRGM BioGRID TAX1BP1 GeneID BioGRID Affinity Capture-Western
    IRGM BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
    IRGM BioGRID RIPK2 GeneID BioGRID Affinity Capture-Western; Co-localization; Reconstituted Complex
    IRGM BioGRID TLR3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    IRGM BioGRID CAMKK1 GeneID BioGRID Affinity Capture-MS
    IRGM BioGRID RALGAPB GeneID BioGRID Affinity Capture-MS
    IRGM BioGRID HOXD13 GeneID BioGRID Affinity Capture-MS
    IRGM BioGRID CFL1 GeneID BioGRID Proximity Label-MS
    IRGM BioGRID MAP1LC3C GeneID BioGRID Affinity Capture-Western; Two-hybrid
    IRGM BioGRID ATG10 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    IRGM BioGRID gag-pol GeneID BioGRID Affinity Capture-Western
    IRGM BioGRID POLY GeneID BioGRID Affinity Capture-Western
    IRGM BioGRID SH3GLB1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    IRGM BioGRID ATG5 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    IRGM BioGRID ULK1 GeneID BioGRID Affinity Capture-Western
    IRGM BioGRID IRGM GeneID BioGRID Affinity Capture-Western
    IRGM BioGRID AMBRA1 GeneID BioGRID Affinity Capture-Western
    IRGM BioGRID ATG16L1 GeneID BioGRID Affinity Capture-Western
    IRGM BioGRID ATG14 GeneID BioGRID Affinity Capture-Western
    IRGM BioGRID BECN1 GeneID BioGRID Affinity Capture-Western
    StringDB
    A B experiments database textmining combined score hadb nhadb
    IRGM LRSAM1 0 0 233 232 1 2
    IRGM TAAR2 0 0 0 185 1 1
    IRGM TTC7A 0 0 241 240 1 1
    IRGM SLC22A4 0 0 390 390 1 1
    IRGM CXCL10 0 0 267 387 1 1
    IRGM CCL5 0 0 203 247 1 1
    IRGM MBOAT7 0 0 126 152 1 1
    IRGM PINK1 0 0 258 258 1 2
    IRGM IFNG 0 0 324 385 1 2
    IRGM IFNGR2 0 0 307 307 1 1
    IRGM CD58 0 0 291 306 1 1
    IRGM HLA-DQA2 0 0 248 265 1 1
    IRGM UBA7 0 0 145 273 1 1
    IRGM LCE3B 0 0 260 293 1 1
    IRGM IRF3 0 0 234 234 1 1
    IRGM TAP1 0 0 48 212 1 1
    IRGM RNF213 0 0 66 205 1 1
    IRGM CCL3L3 0 0 245 244 1 1
    IRGM TNFSF8 0 0 137 155 1 1
    IRGM PYCARD 0 0 181 181 1 1
    IRGM AHSA1 0 0 0 292 1 1
    IRGM TLR9 0 0 323 330 1 1
    IRGM JADE2 0 0 212 212 1 1
    IRGM CLEC7A 0 0 241 259 1 1
    IRGM STAT4 0 0 158 177 1 1
    IRGM CD4 0 0 404 416 1 1
    IRGM IFIT3 0 0 391 483 1 1
    IRGM PIK3R4 0 0 358 358 1 2
    IRGM TRIM25 0 0 138 168 1 1
    IRGM AKT1 0 0 254 254 1 2
    IRGM ENSG00000026036 0 0 164 163 1 1
    IRGM GBP2 0 0 520 590 1 1
    IRGM BCL2L1 0 0 181 181 1 2
    IRGM IL12RB1 0 0 172 181 1 1
    IRGM CSF2 0 0 184 183 1 1
    IRGM LGALS3BP 0 0 81 237 1 1
    IRGM NFKB1 0 0 151 150 1 1
    IRGM AFF3 0 0 328 342 1 1
    IRGM ATG14 270 0 465 592 1 2
    IRGM GAPDH 0 0 193 193 1 2
    IRGM KIR2DL3 0 0 270 270 1 1
    IRGM TLR4 0 0 543 543 1 1
    IRGM TMEM74 0 0 391 429 1 2
    IRGM VMP1 0 0 165 165 1 2
    IRGM ENO1 0 0 270 270 1 1
    IRGM OR6J1 0 0 235 235 1 1
    IRGM SH2B3 0 0 328 328 1 1
    IRGM LCE3C 0 0 246 269 1 1
    IRGM TAAR1 0 0 0 244 1 1
    IRGM NOS2 0 0 241 257 1 1
    IRGM ATF6 0 0 253 252 1 2
    IRGM IKBKB 0 0 136 173 1 1
    IRGM NLRC4 0 0 307 307 1 2
    IRGM OAS2 0 0 184 210 1 1
    IRGM APOA1 0 0 295 295 1 1
    IRGM GABARAPL2 0 0 501 501 1 2
    IRGM TNFSF15 0 0 594 594 1 1
    IRGM RAB5A 0 0 233 232 1 2
    IRGM IL1B 0 0 422 434 1 1
    IRGM STX17 0 0 752 758 1 2
    IRGM SERTM1 0 0 119 184 1 1
    IRGM OAS1 0 0 150 175 1 1
    IRGM JAK1 0 0 154 153 1 1
    IRGM RGS19 0 0 124 175 1 2
    IRGM FOXP3 0 0 240 256 1 1
    IRGM TBK1 0 0 249 248 1 2
    IRGM ATG2B 0 0 243 242 1 2
    IRGM NUDT15 0 0 150 165 1 1
    IRGM TAAR9 0 0 0 221 1 1
    IRGM CXCL8 0 0 204 221 1 1
    IRGM CLN3 0 0 231 244 1 2
    IRGM USP41 0 0 0 251 1 1
    IRGM IFIT1 0 0 328 386 1 1
    IRGM ZFYVE1 0 0 245 244 1 2
    IRGM REG3A 0 0 150 162 1 1
    IRGM FCGR3A 0 0 49 274 1 1
    IRGM MAP1LC3A 0 0 393 392 1 2
    IRGM BNIP3L 0 0 193 219 1 2
    IRGM ERAP1 0 0 181 200 1 1
    IRGM B7RP1 0 0 213 213 1 1
    IRGM HERC5 0 0 154 236 1 1
    IRGM RAB7B 0 0 310 309 1 1
    IRGM LACC1 0 0 325 325 1 1
    IRGM GADD45G 0 0 171 171 1 1
    IRGM MYOM2 0 0 217 217 1 1
    IRGM IRF8 0 0 219 237 1 1
    IRGM CD40LG 0 0 157 156 1 1
    IRGM SHISA4 0 0 156 155 1 1
    IRGM HLA-G 0 0 304 319 1 1
    IRGM ATG4C 0 0 369 369 1 2
    IRGM SLC14A1 0 0 357 357 1 1
    IRGM MTMR3 0 0 341 341 1 2
    IRGM ADAR 0 0 206 255 1 1
    IRGM NLRP1 0 0 229 245 1 1
    IRGM MTOR 0 0 310 309 1 2
    IRGM TM6SF2 0 0 147 159 1 1
    IRGM IL26 0 0 321 321 1 1
    IRGM EVA1A 0 0 108 185 1 2
    IRGM EIF2AK3 0 0 216 233 1 2
    IRGM HNF4A 0 0 218 218 1 1
    IRGM ATL1 0 0 370 406 1 1
    IRGM IL6 0 0 345 359 1 1
    IRGM STAT6 0 0 181 198 1 1
    IRGM MPZ 0 0 0 189 1 1
    IRGM GAD1 0 0 272 272 1 1
    IRGM PIK3C3 0 0 518 518 1 2
    IRGM TNFRSF1A 0 0 213 214 1 1
    IRGM TLR3 270 0 266 454 1 1
    IRGM IL19 0 0 327 327 1 1
    IRGM RSAD2 0 0 295 378 1 1
    IRGM PARP9 0 0 160 696 1 1
    IRGM ATG3 0 0 517 517 1 2
    IRGM STAT1 0 0 427 645 1 1
    IRGM TCFL5 0 0 451 451 1 1
    IRGM TEPP 0 0 142 172 1 1
    IRGM BATF2 0 0 150 220 1 1
    IRGM CFTR 0 0 161 161 1 1
    IRGM TAAR5 0 0 0 221 1 1
    IRGM DDX60 0 0 112 202 1 1
    IRGM TP53 0 0 170 169 1 2
    IRGM LCN2 0 0 120 158 1 1
    IRGM TUSC5 0 0 82 161 1 1
    IRGM IRGQ 0 0 469 469 1 1
    IRGM TGM2 0 0 168 168 1 1
    IRGM IRF9 0 0 274 396 1 1
    IRGM ECM1 0 0 405 418 1 1
    IRGM RPS6KB1 0 0 150 185 1 2
    IRGM MYD88 0 0 391 404 1 1
    IRGM HTT 0 0 150 172 1 1
    IRGM FCGR1A 0 0 138 159 1 1
    IRGM ESX1 0 0 301 301 1 1
    IRGM FADD 0 0 171 171 1 2
    IRGM LAMP1 0 0 335 335 1 2
    IRGM SMIM3 0 0 271 271 1 1
    IRGM AHSA2 0 0 0 292 1 1
    IRGM LECT2 0 0 0 203 1 1
    IRGM PRKAA1 0 0 140 174 1 2
    IRGM INS-IGF2 0 0 306 306 1 1
    IRGM CARD9 0 0 506 506 1 1
    IRGM CAMP 0 0 190 190 1 1
    IRGM CD274 0 0 99 232 1 1
    IRGM SNAP23 0 0 397 397 1 1
    IRGM TCOF1 0 0 67 211 1 1
    IRGM ARPC2 0 0 184 183 1 1
    IRGM ZBP1 0 0 75 205 1 1
    IRGM RNF186 0 0 243 242 1 1
    IRGM DDIT3 0 0 167 167 1 2
    IRGM NLRP4 0 0 166 165 1 1
    IRGM IFIT2 0 0 322 423 1 1
    IRGM EPG5 0 0 217 222 1 2
    IRGM GBF1 0 0 447 447 1 1
    IRGM IFI44 0 0 293 311 1 1
    IRGM HDAC6 0 0 212 212 1 2
    IRGM HLA-DQB1 0 0 388 402 1 1
    IRGM HPRT1 0 0 146 168 1 1
    IRGM CD46 0 0 262 262 1 1
    IRGM VAMP8 0 0 665 671 1 2
    IRGM BAK1 0 0 181 221 1 2
    IRGM HOOK3 0 0 96 260 1 1
    IRGM PTPN2 0 0 518 518 1 2
    IRGM JAK2 0 0 325 339 1 1
    IRGM NLRC5 0 0 142 214 1 1
    IRGM AGR2 0 0 212 212 1 1
    IRGM HGS 0 0 122 160 1 2
    IRGM TECPR1 0 0 213 213 1 2
    IRGM CTLA4 0 0 167 167 1 1
    IRGM ERN1 0 0 249 248 1 2
    IRGM HELZ2 0 0 74 155 1 1
    IRGM STAT3 0 0 370 383 1 2
    IRGM NPHS2 0 0 0 171 1 1
    IRGM ATG2A 0 0 392 392 1 2
    IRGM CANX 0 0 137 168 1 2
    IRGM CD300C 0 0 391 390 1 1
    IRGM EIF2AK4 0 0 166 165 1 1
    IRGM PTPN22 0 0 384 384 1 1
    IRGM PARP12 0 0 134 251 1 1
    IRGM IFNA1 0 0 325 325 1 1
    IRGM PARK2 0 0 165 165 1 1
    IRGM IL18 0 0 369 369 1 1
    IRGM IRGC 0 0 556 262 1 1
    IRGM VDR 0 0 210 210 1 1
    IRGM IFITM3 0 0 218 235 1 1
    IRGM TM9SF1 0 0 184 221 1 2
    IRGM ITGAE 0 0 163 163 1 1
    IRGM TAGAP 0 0 387 386 1 1
    IRGM TNF 0 0 413 419 1 1
    IRGM TNFRSF6B 0 0 164 163 1 1
    IRGM NBR1 0 0 418 432 1 2
    IRGM IFITM1 0 0 182 199 1 1
    IRGM TIRAP 0 0 171 171 1 1
    IRGM LINS 0 0 0 406 1 1
    IRGM IL23R 0 0 681 681 1 1
    IRGM NPC1 0 0 161 162 1 2
    IRGM DCTN4 0 0 82 331 1 1
    IRGM MEFV 0 0 416 416 1 2
    IRGM ENSG00000261832 0 0 234 247 1 1
    IRGM MX1 0 0 264 343 1 1
    IRGM IL2RA 0 0 156 155 1 1
    IRGM C3orf62 0 0 212 212 1 1
    IRGM HERC6 0 0 184 263 1 1
    IRGM CD209 0 0 272 272 1 1
    IRGM WIPI2 0 0 294 294 1 2
    IRGM RAB7A 0 0 320 319 1 2
    IRGM C1QTNF6 0 0 412 412 1 1
    IRGM DRAM1 0 0 424 424 1 2
    IRGM DMBT1 0 0 160 159 1 1
    IRGM FNBP1L 0 0 256 272 1 1
    IRGM OAS3 0 0 138 165 1 1
    IRGM JPH3 0 0 95 190 1 1
    IRGM RUFY4 0 0 163 163 1 2
    IRGM TAX1BP1 0 0 193 193 1 2
    IRGM UBD 0 0 113 168 1 1
    IRGM ACTA1 0 0 167 177 1 1
    IRGM ENSG00000272980 0 0 263 263 1 1
    IRGM IFNAR1 0 0 322 321 1 1
    IRGM TAAR6 0 0 0 203 1 1
    IRGM ATG4B 0 0 417 416 1 2
    IRGM TNFAIP3 0 0 270 276 1 1
    IRGM IRF7 0 0 370 496 1 1
    IRGM APOL1 0 0 231 240 1 2
    IRGM WDFY3 0 0 166 184 1 2
    IRGM DEFB4A 0 0 203 203 1 1
    IRGM UVRAG 0 0 460 459 1 2
    IRGM NEGR1 0 0 266 340 1 1
    IRGM BACH2 0 0 388 388 1 1
    IRGM TLR1 0 0 233 232 1 1
    IRGM SOCS1 0 0 135 174 1 1
    IRGM RB1CC1 0 0 358 358 1 2
    IRGM DHX58 0 0 208 257 1 1
    IRGM IFI35 0 0 207 366 1 1
    IRGM GBP5 0 0 241 297 1 1
    IRGM OASL 0 0 150 310 1 1
    IRGM OR10J3 0 0 170 297 1 1
    IRGM IFIH1 0 0 325 401 1 1
    IRGM MAP1LC3B 0 0 459 460 1 2
    IRGM NPIPB7 0 0 212 212 1 1
    IRGM TUFM 0 0 242 241 1 1
    IRGM ISG15 0 0 304 344 1 1
    IRGM LY6E 0 0 123 158 1 1
    IRGM MX2 0 0 254 334 1 1
    IRGM ADRB1 0 0 0 250 1 1
    IRGM CD244 0 0 294 302 1 1
    IRGM PTGER4 0 0 325 325 1 1
    IRGM USP18 0 0 265 426 1 1
    IRGM GBP3 0 0 425 509 1 1
    IRGM ATG10 270 0 561 671 1 2
    IRGM TSPAN8 0 0 643 643 1 1
    IRGM SEC22B 0 0 135 169 1 1
    IRGM PIP4K2C 0 0 397 396 1 1
    IRGM MAPK8 0 0 170 169 1 2
    IRGM IKBKG 0 0 156 155 1 1
    IRGM NAA25 0 0 398 398 1 1
    IRGM TBX21 0 0 152 151 1 1
    IRGM ULK1 270 0 575 676 1 2
    IRGM PRSS8 0 0 57 201 1 1
    IRGM HLA-DQA1 0 0 321 336 1 1
    IRGM TLR7 0 0 282 297 1 1
    IRGM IFNB1 0 0 390 390 1 1
    IRGM CXCL11 0 0 160 334 1 1
    IRGM IRF5 0 0 325 339 1 1
    IRGM TRAF6 0 0 281 281 1 2
    IRGM ITGAM 0 0 215 215 1 1
    IRGM OPTN 62 0 391 404 1 2
    IRGM ATG4A 0 0 390 390 1 2
    IRGM IL18BP 0 0 155 183 1 1
    IRGM NKX2-3 0 0 601 601 1 2
    IRGM PLIN2 0 0 442 473 1 1
    IRGM ENSG00000100926 0 0 187 224 1 1
    IRGM IL10RB 0 0 218 235 1 1
    IRGM DLK1 0 0 295 295 1 1
    IRGM SH3GLB1 270 0 521 636 1 2
    IRGM SPI1 0 0 161 161 1 1
    IRGM CTSB 0 0 207 207 1 2
    IRGM IL17A 0 0 324 323 1 1
    IRGM CTSH 0 0 398 398 1 1
    IRGM IRF1 0 0 346 490 1 1
    IRGM TRIM5 0 0 138 247 1 2
    IRGM SLC22A5 0 0 401 400 1 1
    IRGM XBP1 0 0 468 468 1 2
    IRGM COMMD4 0 0 150 279 1 1
    IRGM STAT2 0 0 233 332 1 1
    IRGM IRF2 0 0 205 220 1 1
    IRGM CXCL9 0 0 233 357 1 1
    IRGM IL12B 0 0 329 329 1 1
    IRGM TLR8 0 0 187 187 1 1
    IRGM ISG20 0 0 218 240 1 1
    IRGM DLG5 0 0 459 459 1 1
    IRGM CALCOCO2 0 0 560 560 1 2
    IRGM ATG5 270 0 986 989 1 2
    IRGM SLC6A19 0 0 0 177 1 1
    IRGM CCL2 0 0 234 243 1 2
    IRGM KIAA0226 0 0 294 310 1 1
    IRGM CASP8 0 0 194 211 1 2
    IRGM IDO1 0 0 193 208 1 1
    IRGM WIPI1 0 0 391 390 1 2
    IRGM GABARAP 0 0 405 405 1 2
    IRGM ITLN1 0 0 376 387 1 1
    IRGM BST2 0 0 210 296 1 1
    IRGM TRAFD1 0 0 163 189 1 1
    IRGM IRF4 0 0 167 173 1 1
    IRGM NLRP6 0 0 218 218 1 1
    IRGM MMEL1 0 0 398 398 1 1
    IRGM LTA4H 0 0 386 386 1 1
    IRGM GOPC 0 0 394 435 1 2
    IRGM FCGR2A 0 0 171 171 1 1
    IRGM FAM134B 0 0 181 181 1 1
    IRGM IL4 0 0 320 319 1 1
    IRGM NLE1 0 0 45 384 1 1
    IRGM LGALS8 0 0 296 304 1 1
    IRGM IFI44L 0 0 82 186 1 1
    IRGM DRAM2 0 0 207 236 1 2
    IRGM AMBRA1 270 0 501 620 1 2
    IRGM IL17F 0 0 166 165 1 1
    IRGM DDX58 270 0 391 575 1 1
    IRGM AIM2 0 0 217 229 1 1
    IRGM FCGR3B 0 0 81 299 1 1
    IRGM DEFB4B 0 0 154 153 1 1
    IRGM NCF4 0 0 322 321 1 1
    IRGM TMEM201 0 0 195 195 1 1
    IRGM FAM92B 0 0 218 218 1 1
    IRGM VTI1B 0 0 156 155 1 2
    IRGM IL18RAP 0 0 323 323 1 1
    IRGM MB21D1 0 0 218 218 1 1
    IRGM CTSD 0 0 181 181 1 2
    IRGM IL23A 0 0 175 193 1 1
    IRGM TRIM21 0 0 150 215 1 1
    IRGM ATG16L2 0 0 500 500 1 2
    IRGM ZNF365 0 0 294 294 1 1
    IRGM IL10 0 0 401 400 1 1
    IRGM PSMB10 0 0 54 212 1 1
    IRGM FAM26F 0 0 62 175 1 1
    IRGM PVRL4 0 0 134 188 1 1
    IRGM DRD2 0 0 47 183 1 1
    IRGM CMPK2 0 0 112 257 1 1
    IRGM SP110 0 0 431 487 1 1
    IRGM GBP1 0 0 465 543 1 1
    IRGM CCL4 0 0 135 167 1 1
    IRGM ATG7 0 0 595 595 1 2
    IRGM IL1A 0 0 161 170 1 1
    IRGM MAP1LC3C 270 0 370 520 1 2
    IRGM MAVS 0 0 279 279 1 1
    IRGM SLC6A18 0 0 0 252 1 1
    IRGM GRAMD2 0 0 135 285 1 1
    IRGM TRAT1 0 0 185 185 1 1
    IRGM BCL10 0 0 157 156 1 1
    IRGM UBE2L6 0 0 142 190 1 1
    IRGM ATG16L1 270 0 936 951 1 2
    IRGM CIITA 0 0 181 192 1 1
    IRGM PTPRC 0 0 136 161 1 1
    IRGM NOD2 270 0 955 965 1 1
    IRGM BCL2L12 0 0 153 243 1 1
    IRGM DTX3L 0 0 74 299 1 1
    IRGM IL22 0 0 184 183 1 1
    IRGM CSF1 0 0 140 153 1 1
    IRGM PRDM1 0 0 294 309 1 1
    IRGM PTPRN 0 0 326 325 1 1
    IRGM UNC93B1 0 0 108 156 1 1
    IRGM GABARAPL1 0 0 503 503 1 2
    IRGM MRC1 0 0 386 393 1 1
    IRGM RAB24 0 0 279 279 1 2
    IRGM ITGAX 0 0 209 218 1 1
    IRGM SLC11A1 0 0 457 461 1 1
    IRGM SFTPA1 0 0 323 323 1 1
    IRGM ATG9A 0 0 283 293 1 2
    IRGM TNFRSF14 0 0 328 333 1 1
    IRGM HSPA8 0 0 203 203 1 2
    IRGM OLIG3 0 0 397 396 1 1
    IRGM TLR5 0 0 261 277 1 1
    IRGM CCNY 0 0 281 281 1 2
    IRGM GPR29 0 0 263 263 1 1
    IRGM SAMHD1 0 0 127 191 1 1
    IRGM GNA12 0 0 261 274 1 1
    IRGM ATG13 0 0 339 339 1 2
    IRGM IL13 0 0 279 279 1 1
    IRGM ACTB 0 0 213 213 1 1
    IRGM PRKCQ 0 0 295 295 1 2
    IRGM ATG12 0 0 601 610 1 2
    IRGM GBP7 0 0 517 574 1 1
    IRGM CD40 0 0 262 278 1 1
    IRGM CTSS 0 0 266 286 1 1
    IRGM NLRX1 0 0 210 210 1 1
    IRGM B2M 0 0 134 199 1 1
    IRGM TRIM22 0 0 135 209 1 1
    IRGM NPIPB6 0 0 289 288 1 1
    IRGM CYBB 0 0 261 277 1 1
    IRGM SQSTM1 0 0 604 612 1 2
    IRGM BNIP3 0 0 234 234 1 2
    IRGM GPR65 0 0 241 246 1 1
    IRGM TFEB 0 0 279 279 1 2
    IRGM KIF5A 0 0 357 357 1 1
    IRGM PSMB6 0 0 0 201 1 1
    IRGM HSP90AA1 0 0 113 168 1 2
    IRGM NLRP3 0 0 392 392 1 2
    IRGM PLEKHM1 0 0 219 236 1 2
    IRGM REL 0 0 186 186 1 1
    IRGM ATG101 0 0 322 321 1 2
    IRGM PSMG1 0 0 287 286 1 1
    IRGM ATG4D 0 0 391 390 1 2
    IRGM CXCL1 0 0 135 153 1 1
    IRGM CASP3 0 0 218 218 1 2
    IRGM SP100 0 0 307 334 1 1
    IRGM PSMB9 0 0 118 330 1 1
    IRGM SMURF1 0 0 310 309 1 1
    IRGM CLEC16A 0 0 329 329 1 2
    IRGM ENSG00000277117 0 0 213 213 1 1
    IRGM ENSG00000173366 0 0 322 329 1 1
    IRGM IL10RA 0 0 294 309 1 1
    IRGM IL18R1 0 0 294 294 1 1
    IRGM CD86 0 0 124 156 1 1
    IRGM NOD1 270 0 564 676 1 1
    IRGM FUT2 0 0 329 340 1 1
    IRGM TMEM173 0 0 204 216 1 1
    IRGM YKT6 0 0 173 173 1 1
    IRGM DAPK1 0 0 218 227 1 2
    IRGM TYK2 0 0 262 262 1 1
    IRGM CFB 0 0 278 293 1 1
    IRGM TAPBP 0 0 120 209 1 1
    IRGM ITPR3 0 0 306 306 1 1
    IRGM TLR6 0 0 162 161 1 1
    IRGM GORASP2 0 0 155 154 1 1
    IRGM IL2 0 0 205 205 1 1
    IRGM EVI2B 0 0 72 165 1 1
    IRGM ZNF300 0 0 764 764 1 1
    IRGM SCAMP5 0 0 75 235 1 1
    IRGM CASP1 0 0 335 350 1 2
    IRGM SNAPIN 0 0 886 886 1 1
    IRGM BECN1 270 0 892 918 1 2
    IRGM CCL7 0 0 180 190 1 1
    IRGM FRRS1L 0 0 166 165 1 1
    IRGM SNCA 0 0 186 186 1 2
    IRGM CD74 0 0 161 187 1 1
    IRGM ZC3HAV1 0 0 124 188 1 1
    IRGM SNAP29 0 0 325 325 1 2
    IRGM LRRK2 0 0 565 565 1 2
    IRGM C17orf85 0 0 107 171 1 1
    IRGM PADI4 0 0 386 386 1 1
    IRGM NELL1 0 0 158 157 1 1
    IRGM PIK3CG 0 0 138 174 1 1
    IRGM ULK2 0 0 325 325 1 2
    IRGM ORMDL3 0 0 469 502 1 1
    IRGM GBP4 0 0 268 355 1 1
    IRGM HLA-DRB1 0 0 242 258 1 1
    IRGM TLR2 0 0 392 405 1 1
    IRGM CEACAM6 0 0 212 213 1 1
    IRGM TNFSF10 0 0 166 185 1 2
    IRGM DEFA6 0 0 163 163 1 1
    IRGM CD8A 0 0 299 311 1 1
    IRGM GBP6 0 0 335 391 1 1
    IRGM EIF2AK2 0 0 204 240 1 2
    IRGM MAST3 0 0 150 162 1 1
    IRGM PSMB8 0 0 142 304 1 1
    IRGM VIPR1 0 0 182 181 1 1
    IRGM HSPA5 0 0 194 194 1 2
    IRGM SSTR3 0 0 304 304 1 1
    IRGM SLAMF1 0 0 181 181 1 1
    IRGM IFNGR1 0 0 329 329 1 1
    IRGM RIPK2 0 0 374 379 1 1
    IRGM SOCS3 0 0 124 153 1 1
    IRGM LAMP2 0 0 195 195 1 2
    IRGM CCRL2 0 0 265 281 1 1
    IRGM UGT2B17 0 0 142 212 1 1
    IRGM GNMT 0 0 124 151 1 1
    IRGM RILP 0 0 134 197 1 1
    IRGM ERN2 0 0 170 169 1 1
    IRGM IRAK3 0 0 123 177 1 1
    IRGM PARP14 0 0 181 702 1 1
    IRGM LAMB1 0 0 324 323 1 1
    IRGM GTPBP4 0 0 157 156 1 1
    IRGM CLDN2 0 0 167 167 1 1
    IRGM RTP4 0 0 261 385 1 1
    IRGM IL7R 0 0 134 161 1 1
    IRGM IRG1 0 0 209 228 1 1
    IRGM CCR5 0 0 170 188 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0051434 Molecular Function BH3 domain binding enables IMP
    GO:0050700 Molecular Function CARD domain binding enables IMP
    GO:0003925 Molecular Function G protein activity enables IDA
    GO:0005525 Molecular Function GTP binding enables IEA
    GO:0003924 Molecular Function GTPase activity enables IBA
    GO:0003924 Molecular Function GTPase activity enables IDA
    GO:1901612 Molecular Function cardiolipin binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0019901 Molecular Function protein kinase binding enables IPI
    GO:0043539 Molecular Function protein serine/threonine kinase activator activity enables IDA
    GO:0043539 Molecular Function protein serine/threonine kinase activator activity enables IMP
    GO:0030674 Molecular Function protein-macromolecule adaptor activity enables IDA
    GO:0061762 Biological Process CAMKK-AMPK signaling cascade involved_in IMP
    GO:0000045 Biological Process autophagosome assembly involved_in IBA
    GO:0000045 Biological Process autophagosome assembly involved_in IMP
    GO:0097352 Biological Process autophagosome maturation involved_in ISS
    GO:0035458 Biological Process cellular response to interferon-beta involved_in IBA
    GO:0071222 Biological Process cellular response to lipopolysaccharide involved_in IMP
    GO:0098586 Biological Process cellular response to virus involved_in IMP
    GO:0050829 Biological Process defense response to Gram-negative bacterium involved_in IMP
    GO:0042742 Biological Process defense response to bacterium involved_in IDA
    GO:0042742 Biological Process defense response to bacterium involved_in IMP
    GO:0006954 Biological Process inflammatory response involved_in IEA
    GO:0045087 Biological Process innate immune response involved_in IBA
    GO:0045087 Biological Process innate immune response involved_in IMP
    GO:1900226 Biological Process negative regulation of NLRP3 inflammasome complex assembly involved_in IDA
    GO:0160049 Biological Process negative regulation of cGAS/STING signaling pathway involved_in IDA
    GO:0043124 Biological Process negative regulation of canonical NF-kappaB signal transduction involved_in IDA
    GO:0050687 Biological Process negative regulation of defense response to virus involved_in IDA
    GO:0050728 Biological Process negative regulation of inflammatory response involved_in IDA
    GO:0032480 Biological Process negative regulation of type I interferon production involved_in IDA
    GO:0032689 Biological Process negative regulation of type II interferon production involved_in ISS
    GO:0070431 Biological Process nucleotide-binding oligomerization domain containing 2 signaling pathway involved_in IMP
    GO:1901098 Biological Process positive regulation of autophagosome maturation involved_in IMP
    GO:0010508 Biological Process positive regulation of autophagy involved_in IDA
    GO:0010508 Biological Process positive regulation of autophagy involved_in IMP
    GO:1905673 Biological Process positive regulation of lysosome organization involved_in IDA
    GO:0043032 Biological Process positive regulation of macrophage activation involved_in ISS
    GO:0090141 Biological Process positive regulation of mitochondrial fission involved_in IDA
    GO:1901526 Biological Process positive regulation of mitophagy involved_in IDA
    GO:0033138 Biological Process positive regulation of peptidyl-serine phosphorylation involved_in IMP
    GO:0010800 Biological Process positive regulation of peptidyl-threonine phosphorylation involved_in IMP
    GO:0001934 Biological Process positive regulation of protein phosphorylation involved_in IMP
    GO:0071902 Biological Process positive regulation of protein serine/threonine kinase activity involved_in IMP
    GO:0060335 Biological Process positive regulation of type II interferon-mediated signaling pathway involved_in IMP
    GO:1904417 Biological Process positive regulation of xenophagy involved_in IDA
    GO:0031648 Biological Process protein destabilization involved_in IMP
    GO:0061739 Biological Process protein lipidation involved in autophagosome assembly involved_in IMP
    GO:0050821 Biological Process protein stabilization involved_in IMP
    GO:0071211 Biological Process protein targeting to vacuole involved in autophagy involved_in IDA
    GO:0065003 Biological Process protein-containing complex assembly involved_in IDA
    GO:0061635 Biological Process regulation of protein complex stability involved_in IMP
    GO:0043254 Biological Process regulation of protein-containing complex assembly involved_in IMP
    GO:0005794 Cellular Component Golgi apparatus located_in IDA
    GO:0000139 Cellular Component Golgi membrane located_in IDA
    GO:0000421 Cellular Component autophagosome membrane is_active_in IDA
    GO:0042995 Cellular Component cell projection located_in IEA
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005789 Cellular Component endoplasmic reticulum membrane is_active_in IBA
    GO:0031902 Cellular Component late endosome membrane located_in IEA
    GO:0005765 Cellular Component lysosomal membrane is_active_in ISS
    GO:0031966 Cellular Component mitochondrial membrane is_active_in ISS
    GO:0005739 Cellular Component mitochondrion is_active_in IDA
    GO:0005739 Cellular Component mitochondrion located_in IDA
    GO:0001891 Cellular Component phagocytic cup located_in IEA
    GO:0030670 Cellular Component phagocytic vesicle membrane located_in IEA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_170598 1 miscRNA transcript variant 3 NC_000005 Reference
    NM_001346557 2 mRNA transcript variant 1 NC_000005 Reference
    NM_001145805 2 mRNA transcript variant 2 NC_000005 Reference