STING1

stimulator of interferon response cGAMP interactor 1
General Information
Name stimulator of interferon response cGAMP interactor 1
Alias
  • stimulator of interferon genes protein
  • N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
  • endoplasmic reticulum IFN stimulator
  • endoplasmic reticulum interferon stimulator
  • mitochondrial mediator of IRF3 activation
  • stimulator of interferon protein
  • transmembrane protein 173
Synonyms FLJ38577 NET23 ERIS MPYS STING MITA SAVI STING-beta TMEM173 hMITA hSTING
Gene_family None
organism Homo sapiens
entrez_id 340061
location 5q31.2
transcript_count 3
exon_count 8
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
      nextProt (Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). Such oncoproteins prevent the ability to sense cytosolic DNA (PubMed:26405230).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    STING1 BioGRID NLRX1 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID IFI16 GeneID BioGRID Affinity Capture-Western; Co-localization; Reconstituted Complex
    STING1 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID ORF1ab GeneID BioGRID Affinity Capture-Western; Co-localization
    STING1 BioGRID ORF1ab GeneID BioGRID Affinity Capture-Western; Co-localization
    STING1 BioGRID STING1 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID gag-pol GeneID BioGRID Co-localization; Reconstituted Complex
    STING1 BioGRID TBK1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    STING1 BioGRID AMFR GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID TRIM32 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    STING1 BioGRID TRIM10 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    STING1 BioGRID vIRF-1 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID ORF10 GeneID BioGRID Affinity Capture-Western; Co-localization
    STING1 BioGRID ORF1ab GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID ORF1ab GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID orf1ab GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID ORF1ab GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID IKBKE GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID TRAF3 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID IRF3 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID USP35 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    STING1 BioGRID ORF3a GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID ORF1ab GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID IKBKB GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID TRIM56 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID RNF26 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    STING1 BioGRID REC8 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID AXIN1 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID RNF5 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID LMO7 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID DAPK3 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID UBR3 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID ABHD11 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID TKFC GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID DDAH1 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID HARS2 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID SMCHD1 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID FKBP15 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID SEPTIN9 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID CLPP GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID PRKACG GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID MPI GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID COPA GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID CCDC50 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    STING1 BioGRID UL36 GeneID BioGRID Affinity Capture-Western; Co-localization
    STING1 BioGRID MYSM1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    STING1 BioGRID HSD3B7 GeneID BioGRID Proximity Label-MS
    STING1 BioGRID DERL1 GeneID BioGRID Proximity Label-MS
    STING1 BioGRID OTUD5 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID MARCHF1 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID HSD17B11 GeneID BioGRID Proximity Label-MS
    STING1 BioGRID RNF115 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    STING1 BioGRID TMT1A GeneID BioGRID Proximity Label-MS
    STING1 BioGRID SEC61B GeneID BioGRID Proximity Label-MS
    STING1 BioGRID RPN1 GeneID BioGRID Proximity Label-MS
    STING1 BioGRID LEPROTL1 GeneID BioGRID Two-hybrid
    STING1 BioGRID TECR GeneID BioGRID Two-hybrid
    STING1 BioGRID STX5 GeneID BioGRID Two-hybrid
    STING1 BioGRID SMIM1 GeneID BioGRID Two-hybrid
    STING1 BioGRID CMTM5 GeneID BioGRID Two-hybrid
    STING1 BioGRID REEP6 GeneID BioGRID Two-hybrid
    STING1 BioGRID YIPF2 GeneID BioGRID Two-hybrid
    STING1 BioGRID TMEM100 GeneID BioGRID Two-hybrid
    STING1 BioGRID PLLP GeneID BioGRID Two-hybrid
    STING1 BioGRID MAVS GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID OTULINL GeneID BioGRID Proximity Label-MS
    STING1 BioGRID RIGI GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID RHBDD1 GeneID BioGRID Proximity Label-MS
    STING1 BioGRID USP49 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    STING1 BioGRID USP20 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    STING1 BioGRID CGAS GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID H2BC21 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID CYLD GeneID BioGRID Affinity Capture-Western; Co-localization
    STING1 BioGRID MAP3K14 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID TP53 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID FAF2 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID MUL1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    STING1 BioGRID NECTIN4 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID CD40 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID USP50 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID USP22 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID USP18 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID USP3 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID PAN2 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID USP2 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID USP13 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID TOMM70 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID TSPAN6 GeneID BioGRID Affinity Capture-Western
    STING1 BioGRID STT3B GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID TMEM259 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID YIPF5 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID HM13 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID CLPTM1L GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID MBOAT7 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    STING1 BioGRID CCDC47 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    STING1 BioGRID SEC61A1 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID CNNM3 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID LTN1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    STING1 BioGRID SLC39A14 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID GLMN GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID SGPL1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    STING1 BioGRID SURF4 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    STING1 BioGRID ABCC1 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID STT3A GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    STING1 BioGRID IRAK1 GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    STING1 BioGRID ACSL3 GeneID BioGRID Affinity Capture-MS
    STING1 BioGRID DDOST GeneID BioGRID Affinity Capture-MS; Reconstituted Complex
    STING1 BioGRID NPC1 GeneID BioGRID Affinity Capture-MS
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TMEM173 TRAF3 486 0 469 715 2 1
    TMEM173 BECN1 0 0 203 203 2 1
    TMEM173 CASP1 0 0 406 487 2 1
    TMEM173 EIF2AK2 0 0 156 155 2 1
    TMEM173 C19orf12 0 0 0 303 2 1
    TMEM173 ATG16L1 0 0 216 216 2 1
    TMEM173 CASP4 0 0 57 181 2 1
    TMEM173 HSPA8 0 0 306 306 2 1
    TMEM173 ATG9A 0 0 324 323 2 1
    TMEM173 SQSTM1 0 0 240 419 2 1
    TMEM173 STUB1 0 0 326 325 2 1
    TMEM173 ATG12 0 0 204 204 2 1
    TMEM173 MUL1 270 0 194 386 2 1
    TMEM173 CASP3 0 0 124 178 2 1
    TMEM173 NLRP3 0 0 361 388 2 1
    TMEM173 CASP8 0 0 143 183 2 1
    TMEM173 CCL2 0 0 143 159 2 1
    TMEM173 ATG7 0 0 150 172 2 1
    TMEM173 MAP1LC3B 0 0 180 196 2 1
    TMEM173 ULK1 0 0 210 210 2 1
    TMEM173 ITPR1 0 0 459 583 2 1
    TMEM173 ATG4A 0 0 107 389 2 1
    TMEM173 OPTN 0 0 194 194 2 1
    TMEM173 TRAF6 270 0 380 531 2 1
    TMEM173 ATG5 0 0 182 181 2 1
    TMEM173 CALCOCO2 0 0 205 205 2 1
    TMEM173 CCR2 0 0 94 165 2 1
    TMEM173 TRIM5 0 0 194 339 2 1
    TMEM173 NBR1 0 0 91 160 2 1
    TMEM173 IRGM 0 0 204 216 2 1
    TMEM173 MEFV 0 0 401 420 2 1
    TMEM173 NPC1 157 0 112 219 2 1
    TMEM173 ATG4B 0 0 76 179 2 1
    TMEM173 TAX1BP1 0 0 233 232 2 1
    TMEM173 DRAM1 0 0 150 418 2 1
    TMEM173 PRKDC 0 900 96 907 2 1
    TMEM173 FADD 0 0 181 181 2 1
    TMEM173 TP53INP2 0 0 123 157 2 1
    TMEM173 TP53 270 0 162 362 2 1
    TMEM173 PTPN2 0 0 425 425 2 1
    TMEM173 ATG2A 0 0 44 387 2 1
    TMEM173 STAT3 270 0 134 359 2 1
    TMEM173 ATG2B 0 0 0 234 2 1
    TMEM173 TBK1 978 800 983 999 2 1
    TMEM173 MAP1LC3A 0 0 148 354 2 1
    TMEM173 TRIM13 0 0 125 272 2 1
    TMEM173 MFN2 0 0 194 194 2 1
    TMEM173 IFNG 0 0 63 153 2 1
    TMEM173 NLRC4 0 0 284 317 2 1
    TMEM173 GAPDH 0 0 246 245 2 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0061507 Molecular Function 2',3'-cyclic GMP-AMP binding enables IBA
    GO:0061507 Molecular Function 2',3'-cyclic GMP-AMP binding enables IDA
    GO:0061507 Molecular Function 2',3'-cyclic GMP-AMP binding enables ISS
    GO:0061507 Molecular Function 2',3'-cyclic GMP-AMP binding enables TAS
    GO:0061629 Molecular Function RNA polymerase II-specific DNA-binding transcription factor binding enables IDA
    GO:0035438 Molecular Function cyclic-di-GMP binding enables IBA
    GO:0035438 Molecular Function cyclic-di-GMP binding enables IDA
    GO:0042802 Molecular Function identical protein binding enables IPI
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0042803 Molecular Function protein homodimerization activity enables IDA
    GO:0019901 Molecular Function protein kinase binding enables IDA
    GO:0019901 Molecular Function protein kinase binding enables IPI
    GO:0015252 Molecular Function proton channel activity enables IDA
    GO:0035591 Molecular Function signaling adaptor activity enables IDA
    GO:0031625 Molecular Function ubiquitin protein ligase binding enables IEA
    GO:0002218 Biological Process activation of innate immune response involved_in IBA
    GO:0002218 Biological Process activation of innate immune response involved_in IDA
    GO:0002218 Biological Process activation of innate immune response involved_in IMP
    GO:0140374 Biological Process antiviral innate immune response involved_in IDA
    GO:0000045 Biological Process autophagosome assembly involved_in IBA
    GO:0000045 Biological Process autophagosome assembly involved_in IDA
    GO:0140896 Biological Process cGAS/STING signaling pathway involved_in IDA
    GO:0140896 Biological Process cGAS/STING signaling pathway involved_in TAS
    GO:0071360 Biological Process cellular response to exogenous dsRNA involved_in IMP
    GO:0035458 Biological Process cellular response to interferon-beta involved_in IEA
    GO:0002753 Biological Process cytoplasmic pattern recognition receptor signaling pathway involved_in IDA
    GO:0051607 Biological Process defense response to virus involved_in IBA
    GO:0051607 Biological Process defense response to virus involved_in IDA
    GO:0051607 Biological Process defense response to virus involved_in NAS
    GO:0045087 Biological Process innate immune response involved_in IBA
    GO:0045087 Biological Process innate immune response involved_in IDA
    GO:0045087 Biological Process innate immune response involved_in IMP
    GO:0045087 Biological Process innate immune response involved_in TAS
    GO:0002221 Biological Process pattern recognition receptor signaling pathway involved_in IDA
    GO:0051091 Biological Process positive regulation of DNA-binding transcription factor activity involved_in IDA
    GO:0002230 Biological Process positive regulation of defense response to virus by host involved_in IMP
    GO:0032728 Biological Process positive regulation of interferon-beta production involved_in IDA
    GO:0032728 Biological Process positive regulation of interferon-beta production involved_in IMP
    GO:0016239 Biological Process positive regulation of macroautophagy involved_in IBA
    GO:0016239 Biological Process positive regulation of macroautophagy involved_in IDA
    GO:0032092 Biological Process positive regulation of protein binding involved_in IDA
    GO:0045944 Biological Process positive regulation of transcription by RNA polymerase II involved_in IDA
    GO:0032481 Biological Process positive regulation of type I interferon production involved_in IBA
    GO:0032481 Biological Process positive regulation of type I interferon production involved_in IDA
    GO:0060340 Biological Process positive regulation of type I interferon-mediated signaling pathway involved_in IDA
    GO:0051259 Biological Process protein complex oligomerization acts_upstream_of IDA
    GO:0051259 Biological Process protein complex oligomerization involved_in IDA
    GO:0070972 Biological Process protein localization to endoplasmic reticulum involved_in IDA
    GO:1902600 Biological Process proton transmembrane transport involved_in IEA
    GO:0050727 Biological Process regulation of inflammatory response involved_in IEA
    GO:0061709 Biological Process reticulophagy involved_in IBA
    GO:0061709 Biological Process reticulophagy involved_in ISS
    GO:0000139 Cellular Component Golgi membrane is_active_in IDA
    GO:0000139 Cellular Component Golgi membrane located_in IDA
    GO:1990231 Cellular Component STING complex part_of IPI
    GO:0005776 Cellular Component autophagosome is_active_in IBA
    GO:0005776 Cellular Component autophagosome located_in IDA
    GO:0000421 Cellular Component autophagosome membrane located_in IEA
    GO:0036064 Cellular Component ciliary basal body located_in IDA
    GO:0005929 Cellular Component cilium located_in IDA
    GO:0030659 Cellular Component cytoplasmic vesicle membrane located_in TAS
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005789 Cellular Component endoplasmic reticulum membrane is_active_in IBA
    GO:0005789 Cellular Component endoplasmic reticulum membrane is_active_in IDA
    GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IDA
    GO:0005789 Cellular Component endoplasmic reticulum membrane is_active_in TAS
    GO:0005789 Cellular Component endoplasmic reticulum membrane located_in TAS
    GO:0033116 Cellular Component endoplasmic reticulum-Golgi intermediate compartment membrane is_active_in IDA
    GO:0033116 Cellular Component endoplasmic reticulum-Golgi intermediate compartment membrane located_in IDA
    GO:0005768 Cellular Component endosome located_in IDA
    GO:0005741 Cellular Component mitochondrial outer membrane located_in IDA
    GO:0005654 Cellular Component nucleoplasm located_in IDA
    GO:0048471 Cellular Component perinuclear region of cytoplasm located_in ISS
    GO:0005777 Cellular Component peroxisome located_in IEA
    GO:0005886 Cellular Component plasma membrane located_in TAS
    GO:0030667 Cellular Component secretory granule membrane located_in TAS
    GO:1902554 Cellular Component serine/threonine protein kinase complex part_of NAS
    Pathways
    Name DB ID
    Disease Reactome R-HSA-1643685
    Innate Immune System Reactome R-HSA-168249
    Immune System Reactome R-HSA-168256
    STING mediated induction of host immune responses Reactome R-HSA-1834941
    Cytosolic sensors of pathogen-associated DNA Reactome R-HSA-1834949
    Regulation of innate immune responses to cytosolic DNA Reactome R-HSA-3134975
    STAT6-mediated induction of chemokines Reactome R-HSA-3249367
    IRF3-mediated induction of type I IFN Reactome R-HSA-3270619
    Infectious disease Reactome R-HSA-5663205
    Neutrophil degranulation Reactome R-HSA-6798695
    SARS-CoV-1 Infection Reactome R-HSA-9678108
    SARS-CoV Infections Reactome R-HSA-9679506
    SARS-CoV-1-host interactions Reactome R-HSA-9692914
    SARS-CoV-1 activates/modulates innate immune responses Reactome R-HSA-9692916
    SARS-CoV-2 Infection Reactome R-HSA-9694516
    SARS-CoV-2 activates/modulates innate and adaptive immune responses Reactome R-HSA-9705671
    SARS-CoV-2-host interactions Reactome R-HSA-9705683
    Viral Infection Pathways Reactome R-HSA-9824446
    STING pathway in Kawasaki-like disease and COVID-19 (WP4961) WikiPathways WP4961_r123345
    Mitochondrial immune response to SARS-CoV-2 (WP5038) WikiPathways WP5038_r124641
    SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction (WP5183) WikiPathways WP5183_r124655
    Cytosolic DNA-sensing pathway (WP4655) WikiPathways WP4655_r123496
    Novel intracellular components of RIG-I-like receptor pathway (WP3865) WikiPathways WP3865_r123636
    Pathways of nucleic acid metabolism and innate immune sensing (WP4705) WikiPathways WP4705_r123423
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001367258 1 mRNA transcript variant 3 NC_000005 Reference
    NM_001301738 2 mRNA transcript variant 2 NC_000005 Reference
    NM_198282 4 mRNA transcript variant 1 NC_000005 Reference