PIK3R4

phosphoinositide-3-kinase regulatory subunit 4
General Information
Name phosphoinositide-3-kinase regulatory subunit 4
Alias
  • phosphoinositide 3-kinase regulatory subunit 4
  • PI3-kinase p150 subunit
  • PI3-kinase regulatory subunit 4
  • phosphatidylinositol 3-kinase-associated p150
  • phosphoinositide 3-kinase adaptor protein
  • phosphoinositide-3-kinase, regulatory subunit 4, p150
Synonyms VPS15 p150
Gene_family Armadillo like helical domain containing|WD repeat domain containing|PIK3C3 complex subunits
organism Homo sapiens
entrez_id 30849
location 3q22.1
transcript_count 1
exon_count 20
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including early endosome to late endosome transport; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and phosphatidylinositol-3-phosphate biosynthetic process. Located in late endosome and microtubule cytoskeleton. Part of phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Mar 2025]
      Stringdb Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2; Armadillo-like helical domain containing
      nextProt Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    PIK3R4 BioGRID S GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID C9orf72 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID HECTD1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID BAG6 GeneID BioGRID Cross-Linking-MS (XL-MS)
    PIK3R4 BioGRID FBXO22 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID RPA3 GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID DSCR9 GeneID BioGRID Two-hybrid
    PIK3R4 BioGRID DVL2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    PIK3R4 BioGRID USP7 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID PSMA4 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID YWHAH GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID YWHAG GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID NRBF2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    PIK3R4 BioGRID CCT5 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID STIP1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID CCT8 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID CCT2 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID CCT4 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID CCT7 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID BECN1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-purification; FRET
    PIK3R4 BioGRID VBP1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID CCT3 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID TCP1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID PIK3C3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
    PIK3R4 BioGRID PFDN5 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID PFDN4 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID PFDN2 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID PFDN1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID DNAJB1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID CCT6A GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID ATG14 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    PIK3R4 BioGRID PRKN GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID PARP1 GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID USP11 GeneID BioGRID Affinity Capture-Western
    PIK3R4 BioGRID RAB7A GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID UVRAG GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID RPL30 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID RPL7 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID KRAS GeneID BioGRID Negative Genetic
    PIK3R4 BioGRID FLII GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID CKM GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID CAPZB GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID IFITM1 GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID P2RY8 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID KLHL34 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID TUBB GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID SPSB4 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID MGARP GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID RUBCNL GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID DNAI2 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID JADE2 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID GPR182 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID NUBP2 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID RUBCN GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    PIK3R4 BioGRID GPR55 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID FSCN1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID SLC2A1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID MAP2K2 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID MELTF GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID GPR17 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID EEF1G GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID APLNR GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID ATG10 GeneID BioGRID Phenotypic Enhancement
    PIK3R4 BioGRID ATG3 GeneID BioGRID Phenotypic Enhancement
    PIK3R4 BioGRID ATG7 GeneID BioGRID Phenotypic Enhancement
    PIK3R4 BioGRID LAMTOR1 GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID MAPRE3 GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID RAB9A GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID RAB5A GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID LAMP2 GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID NHLRC1 GeneID BioGRID Co-localization
    PIK3R4 BioGRID EPM2A GeneID BioGRID Affinity Capture-Western; Co-localization
    PIK3R4 BioGRID EGFR GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID CEP55 GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID ZBTB24 GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID YWHAE GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID TTN GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID RRBP1 GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID STYK1 GeneID BioGRID Affinity Capture-Western; Co-localization
    PIK3R4 BioGRID RACK1 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    PIK3R4 BioGRID FNDC3B GeneID BioGRID Two-hybrid
    PIK3R4 BioGRID GJA1 GeneID BioGRID Affinity Capture-Western
    PIK3R4 BioGRID STAU1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID VIRMA GeneID BioGRID Affinity Capture-RNA
    PIK3R4 BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
    PIK3R4 BioGRID MTOR GeneID BioGRID Affinity Capture-Western
    PIK3R4 BioGRID MYC GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID EGLN3 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID RIPK4 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID SNW1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID Rassf1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID Tuba3a GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID PARD6A GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID CEP43 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID XRCC3 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID NTRK1 GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID NXF1 GeneID BioGRID Affinity Capture-RNA
    PIK3R4 BioGRID MOV10 GeneID BioGRID Affinity Capture-RNA
    PIK3R4 BioGRID KRIT1 GeneID BioGRID Affinity Capture-Western
    PIK3R4 BioGRID YWHAB GeneID BioGRID Affinity Capture-MS
    PIK3R4 BioGRID MAP1LC3C GeneID BioGRID Affinity Capture-MS
    PIK3R4 Protein MAPRE1 GeneID HPRD None
    PIK3R4 Protein PIK3C3 GeneID HPRD None
    PIK3R4 Protein YWHAB GeneID HPRD None
    StringDB
    A B experiments database textmining combined score hadb nhadb
    PIK3R4 HGS 0 0 362 602 1 2
    PIK3R4 ZFYVE19 0 0 0 207 1 1
    PIK3R4 CISD2 0 0 181 181 1 2
    PIK3R4 RALBP1 0 0 0 151 1 1
    PIK3R4 CAMKK2 0 0 243 337 1 2
    PIK3R4 CYBA 0 0 136 192 1 1
    PIK3R4 HDAC6 0 0 244 266 1 2
    PIK3R4 APAF1 0 0 150 197 1 1
    PIK3R4 SKIV2L 0 0 0 175 1 1
    PIK3R4 VIPAS39 0 0 72 272 1 1
    PIK3R4 GNAT1 0 0 0 422 1 1
    PIK3R4 VAMP8 0 0 369 490 1 2
    PIK3R4 STYK1 270 0 66 289 1 1
    PIK3R4 TP53RK 0 0 260 427 1 1
    PIK3R4 RAB9A 0 0 93 424 1 2
    PIK3R4 CPVL 0 0 0 303 1 1
    PIK3R4 CD300C 0 0 506 506 1 1
    PIK3R4 EIF2AK4 0 0 269 469 1 1
    PIK3R4 SUCLG1 0 0 219 245 1 1
    PIK3R4 OCRL 0 0 155 174 1 1
    PIK3R4 DYNLL1 0 600 0 600 1 1
    PIK3R4 RAB8A 0 0 179 287 1 2
    PIK3R4 MCOLN1 0 0 203 203 1 1
    PIK3R4 PRKAR2A 0 0 96 213 1 1
    PIK3R4 ERN1 0 0 202 354 1 2
    PIK3R4 CFLAR 0 0 134 271 1 1
    PIK3R4 EGFR 0 0 233 237 1 1
    PIK3R4 FES 0 0 0 182 1 1
    PIK3R4 MYD88 0 0 123 177 1 1
    PIK3R4 HTT 0 0 323 393 1 1
    PIK3R4 FADD 0 0 170 241 1 2
    PIK3R4 FGFR3 0 600 0 600 1 1
    PIK3R4 RAB4A 0 0 113 156 1 1
    PIK3R4 LAMP1 0 0 403 495 1 2
    PIK3R4 DDX54 0 0 108 221 1 1
    PIK3R4 SCYL3 0 0 0 209 1 1
    PIK3R4 EPS15 0 0 112 201 1 1
    PIK3R4 CCDC186 0 0 67 150 1 1
    PIK3R4 TP53 0 0 284 284 1 2
    PIK3R4 TGM2 0 0 124 193 1 1
    PIK3R4 MAP1A 0 0 359 373 1 1
    PIK3R4 BCAS3 0 0 66 183 1 2
    PIK3R4 VPS4B 0 0 136 185 1 1
    PIK3R4 RAB10 0 0 125 156 1 1
    PIK3R4 DDIT3 0 0 134 158 1 2
    PIK3R4 MAP3K7 0 0 123 349 1 1
    PIK3R4 CTSA 0 0 47 307 1 1
    PIK3R4 FGF7 0 600 0 609 1 1
    PIK3R4 SNX14 0 0 140 176 1 1
    PIK3R4 PEF1 0 0 0 181 1 1
    PIK3R4 RAF1 0 0 66 241 1 2
    PIK3R4 SNAP23 0 0 0 248 1 1
    PIK3R4 VPS39 0 0 286 508 1 1
    PIK3R4 TAX1BP1 0 0 280 442 1 2
    PIK3R4 GOLPH3 0 0 181 181 1 1
    PIK3R4 CCDC65 0 0 73 326 1 1
    PIK3R4 XRCC3 246 0 0 245 1 1
    PIK3R4 SEC16A 0 0 97 160 1 2
    PIK3R4 AMMECR1L 0 0 152 299 1 1
    PIK3R4 KIAA1161 0 0 204 204 1 1
    PIK3R4 DDX50 0 0 81 193 1 1
    PIK3R4 RUFY1 0 0 57 281 1 1
    PIK3R4 UBA1 0 0 69 216 1 1
    PIK3R4 HDAC3 0 0 143 175 1 1
    PIK3R4 BOLA2 0 0 0 388 1 1
    PIK3R4 MFF 0 0 123 155 1 1
    PIK3R4 MAP2K1 0 0 143 229 1 1
    PIK3R4 STK11 0 0 269 378 1 2
    PIK3R4 DYNC1I2 0 0 0 155 1 1
    PIK3R4 SYNJ1 0 0 134 152 1 1
    PIK3R4 PIP4K2A 0 0 143 270 1 2
    PIK3R4 FRS2 0 600 0 602 1 1
    PIK3R4 MTMR2 0 0 750 761 1 1
    PIK3R4 AKT2 0 0 181 354 1 1
    PIK3R4 EIF3G 0 0 0 369 1 1
    PIK3R4 NFE2L2 0 0 157 156 1 1
    PIK3R4 ALG11 0 0 0 189 1 1
    PIK3R4 RB1CC1 0 900 803 990 1 2
    PIK3R4 MAP2K5 0 0 60 154 1 1
    PIK3R4 FGD5 0 0 0 269 1 1
    PIK3R4 FGF10 0 600 0 609 1 1
    PIK3R4 PPARGC1A 0 0 171 171 1 1
    PIK3R4 PI3 0 0 418 418 1 1
    PIK3R4 VARS2 0 0 95 214 1 1
    PIK3R4 IFT20 0 0 320 360 1 1
    PIK3R4 PARK2 0 0 289 338 1 1
    PIK3R4 IRGM 0 0 358 358 1 2
    PIK3R4 MYC 66 0 215 235 1 2
    PIK3R4 KLB 0 600 0 600 1 1
    PIK3R4 IKBKAP 0 0 97 239 1 1
    PIK3R4 MTFMT 0 0 0 187 1 1
    PIK3R4 CLTA 0 0 0 183 1 1
    PIK3R4 GAB2 0 600 0 600 1 1
    PIK3R4 PIK3CA 0 720 278 877 1 2
    PIK3R4 GNAT2 0 0 0 422 1 1
    PIK3R4 SLC4A1AP 0 0 113 209 1 1
    PIK3R4 GLIPR2 0 0 146 187 1 2
    PIK3R4 PIK3R3 0 540 344 719 1 1
    PIK3R4 NPC1 0 0 112 173 1 2
    PIK3R4 GNAQ 0 0 81 297 1 1
    PIK3R4 RICTOR 0 0 293 303 1 2
    PIK3R4 ENSG00000261832 0 0 183 261 1 1
    PIK3R4 APPL1 0 0 170 198 1 1
    PIK3R4 GNAT3 0 0 0 422 1 1
    PIK3R4 TAB1 0 0 0 198 1 1
    PIK3R4 BCL2L1 0 0 413 412 1 2
    PIK3R4 RAB33B 0 0 147 178 1 2
    PIK3R4 FYCO1 0 0 320 481 1 2
    PIK3R4 NFKB1 0 0 116 177 1 1
    PIK3R4 ITPR2 0 0 49 156 1 1
    PIK3R4 JADE2 304 0 0 319 1 1
    PIK3R4 TSNARE1 0 0 0 220 1 1
    PIK3R4 CASP6 0 0 123 316 1 1
    PIK3R4 C10orf76 0 0 112 268 1 1
    PIK3R4 CABIN1 0 0 49 628 1 1
    PIK3R4 DYNC1I1 0 0 0 155 1 1
    PIK3R4 MAP2K7 0 0 141 194 1 1
    PIK3R4 PELI2 0 0 0 177 1 1
    PIK3R4 PRR5 0 0 150 186 1 1
    PIK3R4 SMG1 0 0 76 411 1 1
    PIK3R4 SCYL1 0 0 90 355 1 1
    PIK3R4 GABARAPL2 0 900 730 983 1 2
    PIK3R4 FKBP8 0 0 201 550 1 1
    PIK3R4 LARS2 0 0 108 152 1 1
    PIK3R4 RIOK2 0 0 113 167 1 1
    PIK3R4 ATG14 904 800 989 999 1 2
    PIK3R4 GAPDH 0 0 193 193 1 2
    PIK3R4 ALG1L 0 0 0 189 1 1
    PIK3R4 PRPF38A 0 0 74 258 1 1
    PIK3R4 ENSG00000258466 0 0 0 205 1 1
    PIK3R4 FGFR2 0 600 0 600 1 1
    PIK3R4 NSF 0 0 155 177 1 1
    PIK3R4 FIG4 0 0 204 240 1 1
    PIK3R4 ARF1 0 0 156 229 1 1
    PIK3R4 PLK1 0 0 112 159 1 1
    PIK3R4 RBM45 0 0 74 236 1 1
    PIK3R4 PDP2 0 0 0 195 1 1
    PIK3R4 TRIP12 0 0 0 165 1 1
    PIK3R4 SLC25A36 0 0 166 184 1 1
    PIK3R4 INPPL1 0 0 120 185 1 1
    PIK3R4 MAP1LC3B2 0 0 97 350 1 2
    PIK3R4 E2F2 0 0 0 422 1 1
    PIK3R4 PLSCR3 0 0 95 191 1 1
    PIK3R4 MTMR3 0 0 261 281 1 2
    PIK3R4 MTOR 270 0 601 811 1 2
    PIK3R4 MAPKAP1 0 0 142 166 1 1
    PIK3R4 CC2D1B 0 0 202 286 1 1
    PIK3R4 MAST1 0 0 0 228 1 1
    PIK3R4 TRAPPC8 0 0 97 193 1 1
    PIK3R4 MAN2C1 0 0 0 189 1 1
    PIK3R4 ARAF 0 0 88 178 1 1
    PIK3R4 RPS6 0 0 166 173 1 1
    PIK3R4 PLEK 0 0 260 260 1 1
    PIK3R4 VPS4A 0 0 205 228 1 1
    PIK3R4 MTMR7 0 0 113 164 1 1
    PIK3R4 SOCS5 0 540 0 540 1 1
    PIK3R4 BCL2L2-PABPN1 0 0 149 176 1 1
    PIK3R4 SCPEP1 0 0 0 151 1 1
    PIK3R4 PIRT 0 0 264 264 1 1
    PIK3R4 WDR34 0 0 71 297 1 1
    PIK3R4 GNA13 0 0 0 413 1 1
    PIK3R4 MYSM1 0 0 0 255 1 1
    PIK3R4 MAPRE1 213 0 0 232 1 1
    PIK3R4 MAP3K2 0 0 66 242 1 1
    PIK3R4 PIK3C3 870 800 989 999 1 2
    PIK3R4 CHMP2B 0 0 184 211 1 2
    PIK3R4 TTC31 0 0 163 181 1 1
    PIK3R4 ARF3 0 0 94 172 1 1
    PIK3R4 KIAA1429 270 0 0 270 1 1
    PIK3R4 CLN3 0 0 187 265 1 2
    PIK3R4 MTMR6 0 0 155 204 1 1
    PIK3R4 TBCCD1 0 0 244 257 1 1
    PIK3R4 RAB5B 0 0 0 484 1 1
    PIK3R4 IL1B 0 0 151 150 1 1
    PIK3R4 NAE1 0 0 0 192 1 1
    PIK3R4 RAB5A 0 0 982 990 1 2
    PIK3R4 BAG3 0 0 193 213 1 2
    PIK3R4 ASTE1 0 0 189 206 1 1
    PIK3R4 NEDD4 0 0 140 161 1 2
    PIK3R4 HIF1A 0 0 162 161 1 2
    PIK3R4 XPO1 0 0 310 333 1 1
    PIK3R4 UQCRB 0 0 61 305 1 1
    PIK3R4 PRKAG1 0 900 0 904 1 1
    PIK3R4 TGFBRAP1 0 0 310 477 1 1
    PIK3R4 MCCC1 0 0 104 214 1 1
    PIK3R4 RAB17 0 0 0 254 1 1
    PIK3R4 ALG1 0 0 0 189 1 1
    PIK3R4 PASK 0 0 0 220 1 1
    PIK3R4 SNX18 0 0 134 167 1 2
    PIK3R4 APP 0 0 193 193 1 1
    PIK3R4 MFN2 0 0 231 286 1 2
    PIK3R4 EXOC8 0 0 181 238 1 1
    PIK3R4 HRAS 0 0 181 283 1 1
    PIK3R4 MAP1LC3A 0 900 460 965 1 2
    PIK3R4 SOCS7 0 540 0 540 1 1
    PIK3R4 MAPK3 0 0 135 151 1 2
    PIK3R4 KEAP1 0 0 203 222 1 2
    PIK3R4 STK38 0 0 74 368 1 1
    PIK3R4 SARAF 0 0 66 620 1 1
    PIK3R4 BRCC3 0 0 0 402 1 1
    PIK3R4 ULK4 0 0 150 230 1 1
    PIK3R4 MPND 0 0 0 238 1 1
    PIK3R4 BNIP3 0 0 459 485 1 2
    PIK3R4 SQSTM1 0 0 606 674 1 2
    PIK3R4 ACTB 0 0 143 174 1 1
    PIK3R4 ATG13 0 900 801 992 1 2
    PIK3R4 GNA14 0 0 0 266 1 1
    PIK3R4 INS 0 0 260 260 1 1
    PIK3R4 C1S 0 0 0 288 1 1
    PIK3R4 FGF1 0 600 0 609 1 1
    PIK3R4 SLA2 0 540 0 540 1 1
    PIK3R4 SETD1A 0 0 0 167 1 1
    PIK3R4 PRPF40B 0 0 0 164 1 1
    PIK3R4 KIF13A 0 0 122 152 1 1
    PIK3R4 PSEN1 0 0 173 173 1 2
    PIK3R4 TFEB 0 0 425 433 1 2
    PIK3R4 HSP90AA1 0 0 430 481 1 2
    PIK3R4 SBF1 0 0 161 200 1 1
    PIK3R4 SP7 0 0 0 163 1 1
    PIK3R4 FBXW7 0 0 357 384 1 1
    PIK3R4 SEC31A 0 0 57 201 1 1
    PIK3R4 RALB 0 0 194 259 1 1
    PIK3R4 PIP5K1B 0 0 61 201 1 1
    PIK3R4 VPS16 0 0 390 718 1 1
    PIK3R4 GABARAPL1 0 900 720 983 1 2
    PIK3R4 RAB1A 0 0 184 196 1 2
    PIK3R4 PMCH 0 0 124 184 1 1
    PIK3R4 MLKL 0 0 81 152 1 1
    PIK3R4 PLEKHF2 0 0 142 346 1 1
    PIK3R4 GNG7 0 0 0 206 1 1
    PIK3R4 CD3D 0 0 0 461 1 1
    PIK3R4 FGF4 0 600 0 609 1 1
    PIK3R4 GNA12 0 0 50 418 1 1
    PIK3R4 VPS28 0 0 241 288 1 1
    PIK3R4 GATSL3 0 0 156 181 1 1
    PIK3R4 RAB24 0 0 285 651 1 2
    PIK3R4 ATG9A 0 900 464 980 1 2
    PIK3R4 ENSG00000249884 0 0 145 207 1 1
    PIK3R4 ZFYVE20 0 900 141 956 1 1
    PIK3R4 HSPA8 0 0 371 393 1 2
    PIK3R4 EIF4G1 0 0 75 153 1 2
    PIK3R4 TCIRG1 0 0 203 252 1 1
    PIK3R4 SLAMF1 0 0 450 450 1 1
    PIK3R4 ENSG00000270024 0 0 152 297 1 1
    PIK3R4 EI24 0 0 154 189 1 2
    PIK3R4 MON1B 0 0 0 188 1 1
    PIK3R4 PPM1F 0 0 0 198 1 1
    PIK3R4 RASD1 0 0 140 185 1 1
    PIK3R4 FUNDC1 0 0 340 340 1 2
    PIK3R4 SAE1 0 0 0 195 1 1
    PIK3R4 IRS2 0 600 134 645 1 1
    PIK3R4 DEPDC5 0 0 66 228 1 1
    PIK3R4 EIF2AK2 0 0 414 446 1 2
    PIK3R4 SNX3 0 0 113 168 1 1
    PIK3R4 MFN1 0 0 166 226 1 1
    PIK3R4 SYNJ2BP 0 0 0 256 1 1
    PIK3R4 FER 0 0 0 182 1 1
    PIK3R4 FGF6 0 600 0 609 1 1
    PIK3R4 GPATCH3 0 0 213 336 1 1
    PIK3R4 ERN2 0 0 45 227 1 1
    PIK3R4 NPRL3 0 0 72 154 1 1
    PIK3R4 MIB2 0 0 0 248 1 1
    PIK3R4 NCOA4 0 0 150 181 1 1
    PIK3R4 ARIH1 0 0 0 164 1 1
    PIK3R4 FTSJ2 0 0 82 178 1 1
    PIK3R4 LAMP2 0 0 459 497 1 2
    PIK3R4 LCK 0 0 90 316 1 1
    PIK3R4 PP2D1 0 0 0 198 1 1
    PIK3R4 YWHAE 351 0 0 406 1 1
    PIK3R4 PIP5K1A 0 0 113 245 1 1
    PIK3R4 GOLGA2 0 0 726 726 1 1
    PIK3R4 GRB2 0 600 83 628 1 1
    PIK3R4 CCDC47 0 0 123 444 1 1
    PIK3R4 DAPK1 0 0 323 323 1 2
    PIK3R4 YKT6 0 0 125 161 1 1
    PIK3R4 ITPR3 0 0 259 342 1 1
    PIK3R4 JUN 0 0 214 214 1 1
    PIK3R4 KL 0 600 0 600 1 1
    PIK3R4 KIAA0226L 129 0 101 251 1 1
    PIK3R4 TSC1 0 0 231 280 1 2
    PIK3R4 SNX1 0 0 181 267 1 1
    PIK3R4 BCL2L11 0 0 180 179 1 1
    PIK3R4 UBA6 0 0 0 204 1 1
    PIK3R4 PIK3CG 0 720 380 923 1 1
    PIK3R4 ULK2 0 600 664 920 1 2
    PIK3R4 PROP1 0 0 0 151 1 1
    PIK3R4 TNFSF10 0 0 95 151 1 2
    PIK3R4 EIF2AK1 0 0 74 250 1 1
    PIK3R4 AKT1S1 0 0 325 325 1 1
    PIK3R4 SNCA 0 0 247 246 1 2
    PIK3R4 SNAP29 0 0 460 682 1 2
    PIK3R4 MOCS3 0 0 0 192 1 1
    PIK3R4 PELI1 0 0 47 182 1 1
    PIK3R4 RAB31 0 0 0 254 1 1
    PIK3R4 GAK 0 0 49 176 1 1
    PIK3R4 SH3GLB1 0 0 596 596 1 2
    PIK3R4 PRKAB2 0 900 71 905 1 1
    PIK3R4 RAB8B 0 0 72 245 1 2
    PIK3R4 EPS15L1 0 0 57 151 1 1
    PIK3R4 GNAZ 0 0 0 413 1 1
    PIK3R4 CNOT10 0 0 97 253 1 1
    PIK3R4 MAPK9 0 0 134 168 1 2
    PIK3R4 WDR36 0 0 60 420 1 1
    PIK3R4 PPM1L 0 0 0 198 1 1
    PIK3R4 IMMT 0 0 210 270 1 1
    PIK3R4 PDP1 0 0 0 195 1 1
    PIK3R4 RAC3 0 0 0 209 1 1
    PIK3R4 CAMKK1 0 0 0 160 1 1
    PIK3R4 EXOC6 0 0 48 151 1 1
    PIK3R4 CYCS 0 0 215 218 1 1
    PIK3R4 GCN1L1 0 0 0 273 1 1
    PIK3R4 TRAF6 0 0 203 239 1 2
    PIK3R4 ATG4A 0 0 405 721 1 2
    PIK3R4 CASP9 0 0 173 173 1 1
    PIK3R4 ITPR1 0 0 261 344 1 2
    PIK3R4 MTM1 0 0 705 718 1 1
    PIK3R4 FLCN 0 0 143 214 1 1
    PIK3R4 MRPS5 0 0 73 273 1 1
    PIK3R4 ANKRD39 0 0 134 171 1 1
    PIK3R4 GNAS 0 0 0 266 1 1
    PIK3R4 VARS 0 0 54 154 1 1
    PIK3R4 RPTOR 0 0 465 614 1 2
    PIK3R4 PSMD4 0 0 112 210 1 1
    PIK3R4 SEC23A 0 0 0 201 1 2
    PIK3R4 PIK3R1 0 720 321 813 1 1
    PIK3R4 CLTC 0 0 146 223 1 1
    PIK3R4 CSE1L 0 0 174 209 1 1
    PIK3R4 HSPA4 0 0 141 200 1 1
    PIK3R4 DAPK3 0 0 53 217 1 2
    PIK3R4 SCFD1 0 0 0 268 1 1
    PIK3R4 CISH 0 540 0 540 1 1
    PIK3R4 VPS52 0 0 90 155 1 1
    PIK3R4 FKBP1A 0 0 189 210 1 2
    PIK3R4 RPS6KB2 0 0 47 172 1 2
    PIK3R4 VPS18 0 0 292 763 1 1
    PIK3R4 KRIT1 270 0 0 270 1 1
    PIK3R4 SESN2 0 0 202 221 1 2
    PIK3R4 IFIH1 0 0 86 202 1 1
    PIK3R4 TNS1 0 0 112 184 1 1
    PIK3R4 GPX4 0 0 46 290 1 1
    PIK3R4 PLD1 0 0 125 246 1 1
    PIK3R4 VPS33A 0 0 202 762 1 1
    PIK3R4 CHERP 0 0 95 497 1 1
    PIK3R4 GAB4 0 0 0 157 1 1
    PIK3R4 FGF18 0 600 45 610 1 1
    PIK3R4 ATP6V0A2 0 0 203 261 1 1
    PIK3R4 TULP2 0 0 0 167 1 1
    PIK3R4 PRKAB1 0 900 94 907 1 2
    PIK3R4 MAPK8 0 0 371 419 1 2
    PIK3R4 RUVBL1 0 0 0 152 1 1
    PIK3R4 PTK2 0 0 203 203 1 1
    PIK3R4 PEX5 0 0 143 196 1 1
    PIK3R4 WAC 0 0 0 354 1 1
    PIK3R4 SNAP47 0 0 0 248 1 1
    PIK3R4 FGF17 0 600 0 609 1 1
    PIK3R4 RAP2B 0 0 147 191 1 1
    PIK3R4 NCF4 0 0 172 190 1 1
    PIK3R4 VPS26A 0 0 158 304 1 1
    PIK3R4 FCF1 0 0 75 292 1 1
    PIK3R4 SH3PXD2A 0 0 0 351 1 1
    PIK3R4 RIC1 0 0 0 201 1 1
    PIK3R4 BCL2L13 0 0 136 155 1 1
    PIK3R4 VPS35 0 0 689 828 1 1
    PIK3R4 RAB9B 0 0 49 396 1 1
    PIK3R4 DDX58 0 0 141 242 1 1
    PIK3R4 SGK494 0 0 0 274 1 1
    PIK3R4 FKBP4 0 0 51 159 1 1
    PIK3R4 MAP3K9 0 0 0 164 1 1
    PIK3R4 SEC31B 0 0 0 188 1 1
    PIK3R4 CHMP3 0 0 155 216 1 1
    PIK3R4 TMUB2 0 0 103 305 1 1
    PIK3R4 TRADD 0 0 123 163 1 1
    PIK3R4 MAP1LC3C 70 900 469 961 1 2
    PIK3R4 DNM2 0 0 107 167 1 1
    PIK3R4 EIF2B4 0 0 66 186 1 1
    PIK3R4 ATG16L2 0 0 390 674 1 2
    PIK3R4 BOLA2B 0 0 0 388 1 1
    PIK3R4 LGALS4 0 0 166 165 1 1
    PIK3R4 VPS54 0 0 112 304 1 1
    PIK3R4 PIK3R5 0 720 401 843 1 1
    PIK3R4 FANCM 0 0 0 185 1 1
    PIK3R4 ABCF2 0 0 0 172 1 1
    PIK3R4 VPS8 0 0 202 398 1 1
    PIK3R4 EIF4E2 0 0 67 159 1 1
    PIK3R4 RABEP1 0 0 212 216 1 1
    PIK3R4 PGK1 0 0 155 193 1 2
    PIK3R4 BCL9 0 0 0 189 1 1
    PIK3R4 KIF16B 0 0 124 173 1 1
    PIK3R4 CASP8 0 0 241 240 1 2
    PIK3R4 SGK2 0 0 0 167 1 1
    PIK3R4 ALB 0 0 134 152 1 1
    PIK3R4 PPM1G 0 0 0 195 1 1
    PIK3R4 ALG1L2 0 0 0 189 1 1
    PIK3R4 PEX12 0 0 81 183 1 1
    PIK3R4 INPP1 0 0 146 168 1 1
    PIK3R4 TRIM39-RPP21 0 0 0 252 1 1
    PIK3R4 PIP5K1C 0 0 154 280 1 1
    PIK3R4 NRDE2 0 0 0 151 1 1
    PIK3R4 DRAM2 0 0 112 176 1 2
    PIK3R4 SEC23B 0 0 0 201 1 2
    PIK3R4 TBCK 0 0 139 199 1 1
    PIK3R4 SH3PXD2B 0 0 0 351 1 1
    PIK3R4 CSNK2A2 0 0 53 217 1 1
    PIK3R4 LGALS8 0 0 211 211 1 1
    PIK3R4 STK35 0 0 0 379 1 1
    PIK3R4 GNB2L1 486 0 450 736 1 1
    PIK3R4 MAD2L2 0 0 143 214 1 1
    PIK3R4 TECPR1 0 0 328 329 1 2
    PIK3R4 DFFA 0 0 0 388 1 1
    PIK3R4 PIP5KL1 0 0 0 184 1 1
    PIK3R4 RRAS2 0 0 70 171 1 1
    PIK3R4 RHEB 0 0 455 530 1 2
    PIK3R4 DNAJC14 0 0 94 150 1 1
    PIK3R4 DDIT4 0 0 171 171 1 1
    PIK3R4 RNASEL 0 0 0 262 1 1
    PIK3R4 ANXA7 0 0 0 199 1 2
    PIK3R4 FGF16 0 600 0 609 1 1
    PIK3R4 NAA20 0 0 0 166 1 1
    PIK3R4 MAP2K2 0 0 81 173 1 1
    PIK3R4 SNRPA1 0 0 0 589 1 1
    PIK3R4 USP13 0 0 218 218 1 1
    PIK3R4 ATG2A 0 0 459 771 1 2
    PIK3R4 MAP4K3 0 0 195 212 1 1
    PIK3R4 CDIPT 0 900 150 912 1 1
    PIK3R4 STXBP3 0 0 0 268 1 1
    PIK3R4 VPS41 0 0 82 159 1 1
    PIK3R4 NOL7 0 0 90 187 1 1
    PIK3R4 PDPK1 0 0 124 190 1 2
    PIK3R4 RPS6KB1 0 0 335 422 1 2
    PIK3R4 CHMP4B 0 0 246 339 1 2
    PIK3R4 PRKDC 0 0 0 388 1 2
    PIK3R4 SESN1 0 0 180 200 1 2
    PIK3R4 IPMK 0 0 194 212 1 1
    PIK3R4 SGK1 0 0 102 220 1 1
    PIK3R4 IRS1 0 600 172 654 1 1
    PIK3R4 PIK3C2B 0 540 394 837 1 1
    PIK3R4 PLSCR2 0 0 95 191 1 1
    PIK3R4 FGF5 0 600 0 609 1 1
    PIK3R4 BCL2L2 0 0 153 152 1 1
    PIK3R4 SNX9 0 0 91 155 1 1
    PIK3R4 EPG5 0 0 379 630 1 2
    PIK3R4 DVL2 270 0 0 270 1 1
    PIK3R4 ATR 0 0 113 478 1 1
    PIK3R4 PRKAA1 0 900 213 934 1 2
    PIK3R4 PPM1K 0 0 0 198 1 1
    PIK3R4 FLT3LG 0 600 0 600 1 1
    PIK3R4 IPPK 0 0 150 292 1 1
    PIK3R4 ULK3 0 0 240 567 1 2
    PIK3R4 MAP3K14 0 0 56 231 1 1
    PIK3R4 ATG4B 0 0 518 775 1 2
    PIK3R4 PPTC7 0 0 0 214 1 1
    PIK3R4 CDC7 0 0 90 205 1 1
    PIK3R4 ATP12A 0 0 171 203 1 1
    PIK3R4 PIK3C2G 0 540 391 802 1 1
    PIK3R4 RAB7A 0 0 767 907 1 2
    PIK3R4 FGF2 0 600 0 609 1 1
    PIK3R4 DRAM1 0 0 416 440 1 2
    PIK3R4 CSNK2A1 0 0 181 323 1 1
    PIK3R4 RUFY4 0 0 113 324 1 2
    PIK3R4 PLEKHA4 270 0 0 270 1 1
    PIK3R4 ANKRD27 0 0 0 177 1 1
    PIK3R4 PARD6A 226 0 0 225 1 1
    PIK3R4 IGF1 0 0 167 167 1 1
    PIK3R4 NDUFV1 0 0 71 565 1 1
    PIK3R4 LRRC58 0 0 142 174 1 1
    PIK3R4 CSNK1G3 0 0 103 234 1 1
    PIK3R4 UVRAG 678 800 989 999 1 2
    PIK3R4 AGK 0 0 67 173 1 1
    PIK3R4 SOCS4 0 540 0 540 1 1
    PIK3R4 WDFY3 0 0 406 488 1 2
    PIK3R4 WDR45 0 0 395 528 1 2
    PIK3R4 SOCS1 0 540 0 540 1 1
    PIK3R4 RAB23 0 0 107 276 1 2
    PIK3R4 TNF 0 0 151 150 1 1
    PIK3R4 SNAP25 0 0 0 248 1 1
    PIK3R4 VPS25 0 0 160 167 1 1
    PIK3R4 NBR1 0 0 560 763 1 2
    PIK3R4 SACM1L 0 0 193 260 1 1
    PIK3R4 LARS 0 0 125 199 1 1
    PIK3R4 VPS11 0 0 280 748 1 2
    PIK3R4 C22orf29 0 0 195 195 1 1
    PIK3R4 TIRAP 0 0 57 157 1 1
    PIK3R4 ZKSCAN5 0 0 96 269 1 1
    PIK3R4 VPS36 0 0 181 264 1 1
    PIK3R4 GNAI2 0 0 52 503 1 1
    PIK3R4 PIK3R2 0 600 341 741 1 1
    PIK3R4 MTMR1 0 0 171 206 1 1
    PIK3R4 VPS51 0 0 690 738 1 1
    PIK3R4 FIS1 0 0 160 159 1 2
    PIK3R4 UBL3 0 0 0 367 1 1
    PIK3R4 MAK16 0 0 95 291 1 1
    PIK3R4 CHMP2A 0 0 74 172 1 2
    PIK3R4 WDR45B 0 0 289 446 1 1
    PIK3R4 WIPI2 0 650 664 944 1 2
    PIK3R4 PLSCR5 0 0 181 214 1 1
    PIK3R4 ZFYVE26 0 0 236 236 1 1
    PIK3R4 PPP1R15A 0 0 433 433 1 2
    PIK3R4 VPS13D 0 0 0 218 1 1
    PIK3R4 AKT1 0 0 427 528 1 2
    PIK3R4 CTDP1 0 0 0 267 1 1
    PIK3R4 MTMR14 0 0 334 359 1 1
    PIK3R4 SGK3 0 0 140 287 1 1
    PIK3R4 UBA5 0 0 0 215 1 1
    PIK3R4 GNAL 0 0 0 266 1 1
    PIK3R4 PATL2 0 0 0 259 1 1
    PIK3R4 FGFR1 0 600 0 600 1 1
    PIK3R4 KIAA1033 0 0 60 157 1 1
    PIK3R4 LETM1 0 0 95 153 1 1
    PIK3R4 NLRC4 0 0 146 177 1 2
    PIK3R4 ATF6 0 0 181 181 1 2
    PIK3R4 ABCF3 0 0 0 272 1 1
    PIK3R4 PSME4 0 0 0 161 1 1
    PIK3R4 PARL 0 0 184 183 1 1
    PIK3R4 VMP1 0 0 556 677 1 2
    PIK3R4 TMEM74 0 0 264 357 1 2
    PIK3R4 OIP5 0 0 0 256 1 1
    PIK3R4 UBQLN1 0 0 92 159 1 2
    PIK3R4 PINK1 0 0 391 552 1 2
    PIK3R4 GJA1 270 0 42 346 1 1
    PIK3R4 PPP3CA 0 0 134 193 1 1
    PIK3R4 PTPN23 0 0 0 173 1 1
    PIK3R4 FGF3 0 600 0 609 1 1
    PIK3R4 SNUPN 0 0 0 157 1 1
    PIK3R4 EIF4EBP1 0 0 284 284 1 1
    PIK3R4 PIKFYVE 0 900 503 981 1 1
    PIK3R4 DHX16 0 0 57 221 1 1
    PIK3R4 PHYKPL 0 0 134 153 1 1
    PIK3R4 MAP3K1 0 0 135 296 1 1
    PIK3R4 RIC8A 0 0 397 435 1 1
    PIK3R4 SNX7 0 0 47 308 1 2
    PIK3R4 PIK3R6 0 720 391 883 1 1
    PIK3R4 DMXL1 0 0 128 312 1 1
    PIK3R4 VTI1A 0 0 0 211 1 1
    PIK3R4 CSNK2A3 0 0 82 241 1 1
    PIK3R4 UBA7 0 0 47 197 1 1
    PIK3R4 PRDX3 0 0 59 327 1 1
    PIK3R4 WDR81 0 0 241 319 1 1
    PIK3R4 GYS2 0 0 0 310 1 1
    PIK3R4 PPM1E 0 0 0 198 1 1
    PIK3R4 PLEKHF1 0 0 0 270 1 2
    PIK3R4 CCZ1B 0 0 248 292 1 1
    PIK3R4 SHISA5 0 0 94 158 1 1
    PIK3R4 WDR24 0 0 107 154 1 1
    PIK3R4 EEA1 0 0 393 419 1 1
    PIK3R4 ENSG00000250232 0 0 113 309 1 1
    PIK3R4 YWHAB 112 0 63 278 1 1
    PIK3R4 FOXO3 0 0 281 293 1 2
    PIK3R4 EVA1A 0 0 140 176 1 2
    PIK3R4 PRPF4B 0 0 113 204 1 1
    PIK3R4 LRBA 0 0 720 726 1 1
    PIK3R4 SRC 0 0 187 233 1 1
    PIK3R4 CD3G 0 0 0 248 1 1
    PIK3R4 ABCD2 0 0 0 161 1 1
    PIK3R4 STAMBP 0 0 47 205 1 1
    PIK3R4 SHISA4 0 0 143 448 1 1
    PIK3R4 CDC42 0 0 150 252 1 1
    PIK3R4 SLK 0 0 171 171 1 1
    PIK3R4 ATG4C 0 0 394 650 1 2
    PIK3R4 IRS4 0 0 202 202 1 1
    PIK3R4 PLSCR1 0 0 53 153 1 1
    PIK3R4 RABGEF1 0 0 261 435 1 1
    PIK3R4 BNIP1 0 0 203 203 1 2
    PIK3R4 ATG3 0 650 734 964 1 2
    PIK3R4 DMXL2 0 0 0 240 1 1
    PIK3R4 PSMD7 0 0 0 192 1 1
    PIK3R4 ZBTB24 131 0 0 150 1 1
    PIK3R4 EIF2AK3 0 0 181 225 1 2
    PIK3R4 MAP3K19 0 0 0 219 1 1
    PIK3R4 RGS19 0 0 147 209 1 2
    PIK3R4 NRBF2 870 800 743 992 1 2
    PIK3R4 TBK1 0 0 229 272 1 2
    PIK3R4 SEC13 0 0 134 218 1 1
    PIK3R4 CHMP4A 0 0 218 266 1 1
    PIK3R4 ATG2B 0 0 335 719 1 2
    PIK3R4 NUBP1 0 0 123 215 1 1
    PIK3R4 UBA3 0 0 43 197 1 1
    PIK3R4 STX17 0 0 530 617 1 2
    PIK3R4 LYST 0 0 647 674 1 1
    PIK3R4 TBPL2 0 0 0 163 1 1
    PIK3R4 RAC2 0 0 127 280 1 1
    PIK3R4 TOMM20 0 0 158 165 1 1
    PIK3R4 RAB11A 0 0 324 390 1 1
    PIK3R4 EIF2S1 0 0 207 207 1 2
    PIK3R4 MITF 0 0 62 166 1 1
    PIK3R4 RRAGA 0 0 210 275 1 2
    PIK3R4 STXBP2 0 0 0 268 1 1
    PIK3R4 CCZ1 0 0 251 295 1 1
    PIK3R4 BNIP3L 0 0 454 470 1 2
    PIK3R4 ALG2 0 0 0 354 1 1
    PIK3R4 IFT88 0 0 159 177 1 1
    PIK3R4 ZNF384 0 0 62 156 1 1
    PIK3R4 ABCD3 0 0 146 343 1 1
    PIK3R4 VAMP7 0 0 181 290 1 1
    PIK3R4 SBF2 0 0 157 182 1 1
    PIK3R4 ISX 0 0 71 366 1 1
    PIK3R4 PPM1D 0 0 57 211 1 1
    PIK3R4 HECTD1 270 0 0 289 1 1
    PIK3R4 PIK3C2A 0 600 358 850 1 2
    PIK3R4 TSC2 0 0 425 510 1 2
    PIK3R4 TRRAP 0 0 0 365 1 1
    PIK3R4 ATP5C1 0 0 59 315 1 1
    PIK3R4 RAB7B 0 0 604 748 1 1
    PIK3R4 VPS45 0 0 324 668 1 1
    PIK3R4 VDAC1 0 0 170 215 1 2
    PIK3R4 ZWINT 0 0 0 368 1 1
    PIK3R4 PIP4K2B 0 0 0 184 1 1
    PIK3R4 ZFYVE1 0 0 681 738 1 2
    PIK3R4 RIPK3 0 0 108 176 1 1
    PIK3R4 BOLA2-SMG1P6 0 0 0 388 1 1
    PIK3R4 PRKCD 0 0 128 151 1 2
    PIK3R4 MAPK15 0 0 138 302 1 2
    PIK3R4 TLK2 0 0 63 177 1 1
    PIK3R4 BMS1 0 0 70 164 1 1
    PIK3R4 DIRAS3 0 0 135 180 1 2
    PIK3R4 KLHL20 0 0 210 227 1 1
    PIK3R4 SETD1B 0 0 0 291 1 1
    PIK3R4 RAB20 0 0 0 254 1 1
    PIK3R4 CYBB 0 0 234 234 1 1
    PIK3R4 HARS 0 0 0 159 1 1
    PIK3R4 ATG12 0 650 802 972 1 2
    PIK3R4 STX16 0 0 0 151 1 1
    PIK3R4 UBA2 0 0 0 192 1 1
    PIK3R4 FGF22 0 600 0 609 1 1
    PIK3R4 PPM1B 0 0 0 232 1 1
    PIK3R4 FGD6 0 0 0 269 1 1
    PIK3R4 CASP3 0 0 253 252 1 2
    PIK3R4 SMURF1 0 0 170 190 1 1
    PIK3R4 GAPVD1 0 0 45 180 1 1
    PIK3R4 FGF19 0 600 0 609 1 1
    PIK3R4 KIAA1244 0 0 91 191 1 1
    PIK3R4 TUB 0 0 0 183 1 1
    PIK3R4 GNA15 0 0 0 266 1 1
    PIK3R4 PLEKHM1 0 0 341 355 1 2
    PIK3R4 REL 0 0 57 228 1 1
    PIK3R4 ATG101 0 900 769 990 1 2
    PIK3R4 PLD2 0 0 54 185 1 1
    PIK3R4 ATG4D 0 0 401 654 1 2
    PIK3R4 RIPK1 0 0 117 211 1 1
    PIK3R4 HDAC1 0 0 125 179 1 2
    PIK3R4 WDR91 0 0 219 247 1 1
    PIK3R4 WDR92 0 0 0 192 1 1
    PIK3R4 PATL1 0 0 72 489 1 1
    PIK3R4 C6orf106 0 0 0 235 1 1
    PIK3R4 PIK3CD 0 540 268 814 1 1
    PIK3R4 ABCD4 0 0 0 205 1 1
    PIK3R4 ATG16L1 0 650 710 943 1 2
    PIK3R4 FGF9 0 600 0 609 1 1
    PIK3R4 NOD2 0 0 180 209 1 1
    PIK3R4 PI4KA 0 0 84 573 1 1
    PIK3R4 CIITA 0 0 0 320 1 1
    PIK3R4 CUL3 0 0 144 217 1 1
    PIK3R4 CHUK 0 0 108 158 1 1
    PIK3R4 GSK3B 0 0 74 170 1 2
    PIK3R4 FGF8 0 600 0 609 1 1
    PIK3R4 CDKN2A 0 0 125 248 1 2
    PIK3R4 SOCS2 0 540 0 540 1 1
    PIK3R4 STAMBPL1 0 0 54 236 1 1
    PIK3R4 CD3E 0 0 0 265 1 1
    PIK3R4 DNAJC13 0 0 175 414 1 1
    PIK3R4 FOXO1 0 0 229 228 1 2
    PIK3R4 KRAS 0 0 132 291 1 1
    PIK3R4 TPTE2 0 0 108 181 1 1
    PIK3R4 TBC1D25 0 0 124 155 1 1
    PIK3R4 SNX2 0 0 74 171 1 1
    PIK3R4 ZNF346 0 0 81 230 1 1
    PIK3R4 MLST8 0 0 334 359 1 2
    PIK3R4 NRAS 0 0 90 200 1 1
    PIK3R4 SLC35B2 0 0 0 197 1 1
    PIK3R4 FGF20 0 600 0 609 1 1
    PIK3R4 HSPA5 0 0 140 226 1 2
    PIK3R4 TFE3 0 0 149 239 1 1
    PIK3R4 COPS6 0 0 0 174 1 1
    PIK3R4 DEPTOR 0 0 287 286 1 1
    PIK3R4 RRAGC 0 0 383 425 1 1
    PIK3R4 SUCLG2 0 0 190 196 1 1
    PIK3R4 PTPN11 0 600 0 601 1 1
    PIK3R4 GAB1 0 600 0 693 1 1
    PIK3R4 SOCS3 0 540 0 540 1 1
    PIK3R4 TMUB1 0 0 93 185 1 1
    PIK3R4 MON1A 0 0 213 333 1 1
    PIK3R4 PPM1N 0 0 0 207 1 1
    PIK3R4 GRID2 0 0 577 577 1 2
    PIK3R4 NOD1 0 0 150 190 1 1
    PIK3R4 GNAI3 0 0 0 422 1 2
    PIK3R4 IKBIP 0 0 81 175 1 1
    PIK3R4 ZMYND8 0 0 0 177 1 1
    PIK3R4 ATP6V0A4 0 0 229 285 1 1
    PIK3R4 SNX16 0 0 125 184 1 1
    PIK3R4 TBPL1 0 0 0 163 1 1
    PIK3R4 RRAGD 0 0 183 239 1 1
    PIK3R4 GNAO1 0 0 0 422 1 1
    PIK3R4 MLH1 0 0 0 167 1 1
    PIK3R4 CCDC22 0 0 81 323 1 1
    PIK3R4 LRRK2 0 0 177 245 1 2
    PIK3R4 PPM1A 0 0 0 213 1 1
    PIK3R4 FGF23 0 600 0 721 1 1
    PIK3R4 PIK3CB 0 600 427 922 1 1
    PIK3R4 CDKN2B 0 0 0 179 1 1
    PIK3R4 VAC14 0 540 259 669 1 1
    PIK3R4 PMAIP1 0 0 195 195 1 1
    PIK3R4 RBM22 0 0 72 574 1 1
    PIK3R4 STXBP1 0 0 0 268 1 1
    PIK3R4 GYS1 0 0 0 394 1 1
    PIK3R4 SNX4 0 0 156 244 1 1
    PIK3R4 MTMR12 0 0 137 156 1 1
    PIK3R4 STK38L 0 0 0 346 1 1
    PIK3R4 BECN1 963 800 989 999 1 2
    PIK3R4 MCL1 0 0 240 239 1 2
    PIK3R4 INPP4A 0 0 173 173 1 1
    PIK3R4 RAB22A 0 0 60 269 1 1
    PIK3R4 SIRT1 0 0 232 264 1 2
    PIK3R4 CTSB 0 0 173 224 1 2
    PIK3R4 ABCD1 0 0 0 161 1 1
    PIK3R4 RAC1 0 0 75 186 1 1
    PIK3R4 HMGB1 0 0 160 159 1 2
    PIK3R4 PDIK1L 0 0 0 379 1 1
    PIK3R4 COPS5 0 0 0 177 1 1
    PIK3R4 GNA11 0 0 57 278 1 1
    PIK3R4 UBQLN2 0 0 113 179 1 2
    PIK3R4 OPTN 0 0 455 455 1 2
    PIK3R4 MAP3K5 0 0 138 263 1 1
    PIK3R4 ILKAP 0 0 0 198 1 1
    PIK3R4 WDR18 0 0 155 173 1 1
    PIK3R4 MT-ND1 0 0 0 200 1 1
    PIK3R4 ATG5 0 650 751 966 1 2
    PIK3R4 CALCOCO2 0 0 517 517 1 2
    PIK3R4 ATP4A 0 0 171 206 1 1
    PIK3R4 PRKAG2 0 900 0 903 1 1
    PIK3R4 MIB1 0 0 0 248 1 1
    PIK3R4 XBP1 0 0 182 181 1 2
    PIK3R4 DYRK1A 0 0 90 168 1 1
    PIK3R4 USP30 0 0 175 194 1 1
    PIK3R4 SOCS6 0 540 0 540 1 1
    PIK3R4 TSG101 0 0 154 239 1 2
    PIK3R4 ATG10 0 0 734 898 1 2
    PIK3R4 ZC3H14 0 0 74 216 1 1
    PIK3R4 VAMP3 0 0 113 204 1 1
    PIK3R4 TTC19 0 0 202 273 1 1
    PIK3R4 PIGA 0 0 54 200 1 1
    PIK3R4 MAP1LC3B 0 900 469 960 1 2
    PIK3R4 VPS33B 0 0 107 595 1 1
    PIK3R4 WDFY4 0 0 0 174 1 1
    PIK3R4 AGFG1 0 0 200 205 1 1
    PIK3R4 ULK1 0 900 760 985 1 2
    PIK3R4 STX7 0 0 66 240 1 2
    PIK3R4 RIPK4 0 0 0 175 1 1
    PIK3R4 PLAA 0 0 52 160 1 1
    PIK3R4 MAPKAPK3 0 0 138 224 1 1
    PIK3R4 AKT3 0 0 165 313 1 1
    PIK3R4 PIP4K2C 0 0 147 274 1 1
    PIK3R4 PAQR3 0 0 126 161 1 2
    PIK3R4 DYNLL2 0 600 0 600 1 1
    PIK3R4 PSMD14 0 0 0 254 1 1
    PIK3R4 TBP 0 0 66 185 1 1
    PIK3R4 PRKAG3 0 900 54 905 1 1
    PIK3R4 STX12 0 0 0 227 1 1
    PIK3R4 REV3L 0 0 0 152 1 1
    PIK3R4 ATM 0 0 123 256 1 1
    PIK3R4 VTI1B 0 0 278 401 1 2
    PIK3R4 CTSD 0 0 273 316 1 2
    PIK3R4 EIF3F 0 0 0 177 1 1
    PIK3R4 AMPH 0 0 118 193 1 1
    PIK3R4 POLI 0 0 0 159 1 1
    PIK3R4 ENSG00000267261 0 0 0 485 1 1
    PIK3R4 GNAI1 0 0 0 422 1 1
    PIK3R4 LIN9 0 0 380 380 1 1
    PIK3R4 CLTB 0 0 0 183 1 1
    PIK3R4 ATG7 0 0 734 908 1 2
    PIK3R4 SNX30 0 0 0 304 1 1
    PIK3R4 TGFBR2 0 0 0 170 1 1
    PIK3R4 MON2 0 0 66 312 1 1
    PIK3R4 FLT3 0 600 43 600 1 1
    PIK3R4 FGFR4 0 600 0 600 1 1
    PIK3R4 FMN1 0 0 0 312 1 1
    PIK3R4 PPP3R1 0 0 94 190 1 1
    PIK3R4 ATP6V0A1 0 0 218 275 1 1
    PIK3R4 VPS26B 0 0 0 204 1 1
    PIK3R4 PTEN 0 0 321 376 1 2
    PIK3R4 RAB5C 0 0 67 498 1 1
    PIK3R4 GABARAP 0 900 607 976 1 2
    PIK3R4 FEZ1 0 0 150 183 1 1
    PIK3R4 KIAA0226 486 0 886 941 1 1
    PIK3R4 PRKAA2 0 900 232 936 1 2
    PIK3R4 PI4KB 0 0 205 616 1 1
    PIK3R4 RRAGB 0 0 290 348 1 2
    PIK3R4 DNM1L 0 0 243 300 1 2
    PIK3R4 WIPI1 0 0 740 881 1 2
    PIK3R4 NFKBIA 0 0 74 207 1 1
    PIK3R4 ENSG00000273398 0 0 0 161 1 1
    PIK3R4 AMBRA1 0 600 985 994 1 2
    PIK3R4 NEURL4 0 0 74 283 1 1
    PIK3R4 MAP3K3 0 0 57 232 1 1
    PIK3R4 FAM134B 0 0 211 215 1 1
    PIK3R4 MARK2 0 0 188 205 1 1
    PIK3R4 TP53BP2 0 0 134 188 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0004676 Molecular Function 3-phosphoinositide-dependent protein kinase activity enables IEA
    GO:0004679 Molecular Function AMP-activated protein kinase activity enables IEA
    GO:0005524 Molecular Function ATP binding enables IEA
    GO:0004677 Molecular Function DNA-dependent protein kinase activity enables IEA
    GO:0072518 Molecular Function Rho-dependent protein serine/threonine kinase activity enables IEA
    GO:0004694 Molecular Function eukaryotic translation initiation factor 2alpha kinase activity enables IEA
    GO:0044024 Molecular Function histone H2AS1 kinase activity enables IEA
    GO:0072371 Molecular Function histone H2AS121 kinase activity enables IEA
    GO:1990244 Molecular Function histone H2AT120 kinase activity enables IEA
    GO:0035979 Molecular Function histone H2AXS139 kinase activity enables IEA
    GO:0044025 Molecular Function histone H2BS14 kinase activity enables IEA
    GO:0140823 Molecular Function histone H2BS36 kinase activity enables IEA
    GO:0035175 Molecular Function histone H3S10 kinase activity enables IEA
    GO:0044022 Molecular Function histone H3S28 kinase activity enables IEA
    GO:0140855 Molecular Function histone H3S57 kinase activity enables IEA
    GO:0035402 Molecular Function histone H3T11 kinase activity enables IEA
    GO:0072354 Molecular Function histone H3T3 kinase activity enables IEA
    GO:0140857 Molecular Function histone H3T45 kinase activity enables IEA
    GO:0035403 Molecular Function histone H3T6 kinase activity enables IEA
    GO:0044023 Molecular Function histone H4S1 kinase activity enables IEA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0004672 Molecular Function protein kinase activity enables NAS
    GO:0106310 Molecular Function protein serine kinase activity enables IEA
    GO:0004674 Molecular Function protein serine/threonine kinase activity enables IBA
    GO:0004711 Molecular Function ribosomal protein S6 kinase activity enables IEA
    GO:0097352 Biological Process autophagosome maturation involved_in IDA
    GO:0042149 Biological Process cellular response to glucose starvation involved_in ISS
    GO:0006338 Biological Process chromatin remodeling involved_in IEA
    GO:0045022 Biological Process early endosome to late endosome transport involved_in IDA
    GO:0045324 Biological Process late endosome to vacuole transport involved_in IBA
    GO:0000425 Biological Process pexophagy involved_in IBA
    GO:0043491 Biological Process phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_in IDA
    GO:0036092 Biological Process phosphatidylinositol-3-phosphate biosynthetic process involved_in IDA
    GO:0006468 Biological Process protein phosphorylation involved_in NAS
    GO:0006622 Biological Process protein targeting to lysosome involved_in NAS
    GO:0006623 Biological Process protein targeting to vacuole involved_in IBA
    GO:0032801 Biological Process receptor catabolic process involved_in IMP
    GO:0010506 Biological Process regulation of autophagy involved_in IDA
    GO:0032465 Biological Process regulation of cytokinesis involved_in IMP
    GO:0016241 Biological Process regulation of macroautophagy involved_in IDA
    GO:0005776 Cellular Component autophagosome located_in IEA
    GO:0005930 Cellular Component axoneme located_in ISS
    GO:0036064 Cellular Component ciliary basal body located_in IDA
    GO:0005929 Cellular Component cilium located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0045171 Cellular Component intercellular bridge located_in IDA
    GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
    GO:0005770 Cellular Component late endosome is_active_in IBA
    GO:0005770 Cellular Component late endosome located_in IDA
    GO:0016020 Cellular Component membrane located_in HDA
    GO:0015630 Cellular Component microtubule cytoskeleton located_in IDA
    GO:0071561 Cellular Component nucleus-vacuole junction is_active_in IBA
    GO:0030670 Cellular Component phagocytic vesicle membrane located_in TAS
    GO:0035032 Cellular Component phosphatidylinositol 3-kinase complex, class III part_of IPI
    GO:0035032 Cellular Component phosphatidylinositol 3-kinase complex, class III part_of ISS
    GO:0034271 Cellular Component phosphatidylinositol 3-kinase complex, class III, type I part_of IBA
    GO:0034272 Cellular Component phosphatidylinositol 3-kinase complex, class III, type II part_of IBA
    Pathways
    Name DB ID
    PI3K Cascade Reactome R-HSA-109704
    IRS-mediated signalling Reactome R-HSA-112399
    Adaptive Immune System Reactome R-HSA-1280218
    Metabolism Reactome R-HSA-1430728
    PI Metabolism Reactome R-HSA-1483255
    Phospholipid metabolism Reactome R-HSA-1483257
    Signal Transduction Reactome R-HSA-162582
    Macroautophagy Reactome R-HSA-1632852
    Disease Reactome R-HSA-1643685
    Synthesis of PIPs at the Golgi membrane Reactome R-HSA-1660514
    Synthesis of PIPs at the early endosome membrane Reactome R-HSA-1660516
    Synthesis of PIPs at the late endosome membrane Reactome R-HSA-1660517
    Toll Like Receptor 9 (TLR9) Cascade Reactome R-HSA-168138
    Innate Immune System Reactome R-HSA-168249
    Immune System Reactome R-HSA-168256
    Toll-like Receptor Cascades Reactome R-HSA-168898
    Signaling by Rho GTPases Reactome R-HSA-194315
    RHO GTPase Effectors Reactome R-HSA-195258
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Reactome R-HSA-2404192
    IGF1R signaling cascade Reactome R-HSA-2428924
    IRS-related events triggered by IGF1R Reactome R-HSA-2428928
    Metabolism of lipids Reactome R-HSA-556833
    Infectious disease Reactome R-HSA-5663205
    RHO GTPases Activate NADPH Oxidases Reactome R-HSA-5668599
    Insulin receptor signalling cascade Reactome R-HSA-74751
    Signaling by Insulin receptor Reactome R-HSA-74752
    Signaling by Receptor Tyrosine Kinases Reactome R-HSA-9006934
    Autophagy Reactome R-HSA-9612973
    SARS-CoV-1 Infection Reactome R-HSA-9678108
    Translation of Replicase and Assembly of the Replication Transcription Complex Reactome R-HSA-9679504
    SARS-CoV Infections Reactome R-HSA-9679506
    SARS-CoV-2 Infection Reactome R-HSA-9694516
    Translation of Replicase and Assembly of the Replication Transcription Complex Reactome R-HSA-9694676
    SARS-CoV-2 activates/modulates innate and adaptive immune responses Reactome R-HSA-9705671
    SARS-CoV-2-host interactions Reactome R-HSA-9705683
    Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Reactome R-HSA-9716542
    Early SARS-CoV-2 Infection Events Reactome R-HSA-9772572
    Viral Infection Pathways Reactome R-HSA-9824446
    Class I MHC mediated antigen processing & presentation Reactome R-HSA-983169
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC Reactome R-HSA-983170
    Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
    Osteoblast differentiation and related diseases (WP4787) WikiPathways WP4787_r118872
    Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
    Regulation of actin cytoskeleton (WP51) WikiPathways WP51_r116716
    Neural crest cell migration during development (WP4564) WikiPathways WP4564_r124549
    SARS-CoV-2 replication organelle formation (WP5156) WikiPathways WP5156_r120744
    Focal adhesion: PI3K-Akt-mTOR-signaling pathway (WP3932) WikiPathways WP3932_r124527
    DNA damage response (only ATM dependent) (WP710) WikiPathways WP710_r116542
    Insulin signaling (WP481) WikiPathways WP481_r120562
    Host-pathogen interaction of human coronaviruses - autophagy (WP4863) WikiPathways WP4863_r124639
    Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway (WP4577) WikiPathways WP4577_r123500
    Neural crest cell migration in cancer (WP4565) WikiPathways WP4565_r124548
    Phosphoinositides metabolism (WP4971) WikiPathways WP4971_r122106
    Ciliopathies (WP4803) WikiPathways WP4803_r110008
    Autophagy (WP4923) WikiPathways WP4923_r110416
    Angiopoietin-like protein 8 regulatory pathway (WP3915) WikiPathways WP3915_r123920
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_014602 3 mRNA None NC_000003 Reference