NRBF2

nuclear receptor binding factor 2
General Information
Name nuclear receptor binding factor 2
Alias
  • nuclear receptor-binding factor 2
  • comodulator of PPAR and RXR 1
  • comodulator of PPAR and RXR 2
Synonyms DKFZp564C1664 FLJ30395 COPR1 COPR2 COPR NRBF-2
Gene_family PIK3C3 complex subunits
organism Homo sapiens
entrez_id 29982
location 10q21.3
transcript_count 3
exon_count 5
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Involved in autophagy. Located in cytoplasm and phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Mar 2025]
      Stringdb Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro)
      nextProt May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    NRBF2 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID HECTD1 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID KBTBD4 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID PIK3R4 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    NRBF2 BioGRID OVOL2 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID RAB14 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID ATL3 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID ATG14 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    NRBF2 BioGRID SPTLC1 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID SEC24D GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID POLR1C GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID USP11 GeneID BioGRID Affinity Capture-Western
    NRBF2 BioGRID TAF12 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID SEC13 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID MTCL3 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID PAXBP1 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID CCDC183 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID CCM2 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID NAA25 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID NAA40 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID VPS33A GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID PBLD GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID SCOC GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID UQCC1 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID SCHIP1 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID PMF1 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID TGFBRAP1 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID BECN1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    NRBF2 BioGRID PIK3C3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    NRBF2 BioGRID GALT GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID EIF1AX GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID SHANK3 GeneID BioGRID Two-hybrid
    NRBF2 BioGRID TSC1 GeneID BioGRID Two-hybrid
    NRBF2 BioGRID ATG10 GeneID BioGRID Phenotypic Enhancement
    NRBF2 BioGRID ATG3 GeneID BioGRID Phenotypic Enhancement
    NRBF2 BioGRID ATG7 GeneID BioGRID Phenotypic Enhancement
    NRBF2 BioGRID SEPTIN10 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID SQSTM1 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID VASP GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID KRT8 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID ASXL1 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    NRBF2 BioGRID UNK GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID CNOT9 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID STYK1 GeneID BioGRID Affinity Capture-Western
    NRBF2 BioGRID KDM1A GeneID BioGRID Two-hybrid
    NRBF2 BioGRID CDC23 GeneID BioGRID Two-hybrid
    NRBF2 BioGRID PRKAA2 GeneID BioGRID Two-hybrid
    NRBF2 BioGRID CCNC GeneID BioGRID Two-hybrid
    NRBF2 BioGRID RPTOR GeneID BioGRID Biochemical Activity
    NRBF2 BioGRID RB1CC1 GeneID BioGRID Affinity Capture-Western
    NRBF2 BioGRID ULK1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    NRBF2 BioGRID NRBF2 GeneID BioGRID Affinity Capture-Western; Co-purification
    NRBF2 BioGRID RHOU GeneID BioGRID Reconstituted Complex
    NRBF2 BioGRID SASS6 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID CEP128 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID FBF1 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID CEP44 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID EWSR1 GeneID BioGRID Proximity Label-MS
    NRBF2 BioGRID CALCOCO2 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID C1orf216 GeneID BioGRID Two-hybrid
    NRBF2 BioGRID Prkaa1 GeneID BioGRID Affinity Capture-Western
    NRBF2 BioGRID IKBKG GeneID BioGRID Reconstituted Complex
    NRBF2 BioGRID CPVL GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID PGK1 GeneID BioGRID Affinity Capture-MS
    NRBF2 BioGRID PA2G4 GeneID BioGRID Affinity Capture-MS
    NRBF2 Protein THRB GeneID HPRD None
    NRBF2 Protein RARA GeneID HPRD None
    NRBF2 Protein HNF4A GeneID HPRD None
    NRBF2 Protein RXRA GeneID HPRD None
    NRBF2 Protein PPARA GeneID HPRD None
    NRBF2 BioGRID RXRA GeneID BioGRID Two-hybrid
    NRBF2 BioGRID RARA GeneID BioGRID Two-hybrid
    NRBF2 BioGRID PPARA GeneID BioGRID Two-hybrid
    NRBF2 BioGRID THRB GeneID BioGRID Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    NRBF2 DNTTIP2 0 0 208 208 1 1
    NRBF2 MAPKAPK2 0 0 210 210 1 1
    NRBF2 LIN9 0 0 459 459 1 1
    NRBF2 TMEM39A 0 0 310 328 1 1
    NRBF2 OXT 0 0 0 189 1 1
    NRBF2 JMJD1C 0 0 467 509 1 1
    NRBF2 MTOR 0 0 156 155 1 2
    NRBF2 RHOU 270 0 0 270 1 1
    NRBF2 SLITRK5 0 0 157 156 1 1
    NRBF2 MTMR3 0 0 181 181 1 2
    NRBF2 GALT 283 0 0 282 1 1
    NRBF2 PIK3C3 871 800 900 997 1 2
    NRBF2 PA2G4 288 0 0 288 1 1
    NRBF2 PIK3R5 0 360 0 360 1 1
    NRBF2 ZNF365 0 0 253 252 1 1
    NRBF2 ZSWIM5 0 0 241 240 1 1
    NRBF2 HNF4A 213 0 0 213 1 1
    NRBF2 PIRT 0 0 240 239 1 1
    NRBF2 CCDC85B 0 0 218 218 1 1
    NRBF2 MAP1LC3C 0 0 170 169 1 2
    NRBF2 SOCS5 0 360 0 360 1 1
    NRBF2 COG6 0 0 248 248 1 1
    NRBF2 ATG7 0 0 293 293 1 2
    NRBF2 ATG3 0 0 297 323 1 2
    NRBF2 CCZ1 0 0 156 155 1 1
    NRBF2 WIPI1 0 0 310 309 1 2
    NRBF2 LCOR 0 0 234 234 1 1
    NRBF2 RAB5A 0 0 194 243 1 2
    NRBF2 SNX32 0 0 195 195 1 1
    NRBF2 STX17 0 0 297 297 1 2
    NRBF2 PMF1 187 0 0 187 1 1
    NRBF2 KIAA0226 0 0 466 466 1 1
    NRBF2 PGK1 129 0 74 158 1 2
    NRBF2 CBLN4 0 0 158 157 1 1
    NRBF2 GABARAP 0 0 261 261 1 2
    NRBF2 GTF2IRD1 0 0 0 171 1 1
    NRBF2 MBP 0 0 0 207 1 1
    NRBF2 SLC6A2 0 0 0 189 1 1
    NRBF2 RQCD1 167 0 0 167 1 1
    NRBF2 DSTYK 0 0 211 211 1 1
    NRBF2 CTTNBP2 0 0 183 183 1 1
    NRBF2 SOCS7 0 360 0 360 1 1
    NRBF2 BET1L 0 0 216 216 1 1
    NRBF2 CTCF 0 0 0 189 1 1
    NRBF2 ZFYVE1 0 0 393 392 1 2
    NRBF2 FAM134B 0 0 181 181 1 1
    NRBF2 APP 0 0 165 165 1 1
    NRBF2 EFHD2 0 0 156 155 1 1
    NRBF2 RAB7B 0 0 283 282 1 1
    NRBF2 TGFBRAP1 296 0 0 296 1 1
    NRBF2 AMBRA1 0 0 338 345 1 2
    NRBF2 PIK3C2A 0 360 0 360 1 2
    NRBF2 HECTD1 270 0 0 270 1 1
    NRBF2 ERAP1 0 0 162 161 1 1
    NRBF2 UCN3 0 0 0 641 1 1
    NRBF2 PIK3R4 870 800 743 992 1 2
    NRBF2 OPTN 0 0 188 188 1 2
    NRBF2 NSD1 0 0 205 205 1 1
    NRBF2 LONRF2 0 0 212 212 1 1
    NRBF2 AFF3 0 0 201 201 1 1
    NRBF2 COPG1 0 0 284 284 1 1
    NRBF2 SH3GLB1 0 0 286 329 1 2
    NRBF2 UBLCP1 0 0 210 210 1 1
    NRBF2 SLC6A11 0 0 0 329 1 1
    NRBF2 TIMMDC1 0 0 361 361 1 1
    NRBF2 EDF1 0 0 155 154 1 1
    NRBF2 PIK3R1 0 360 0 360 1 1
    NRBF2 SLC6A3 0 0 0 189 1 1
    NRBF2 ATG14 870 800 912 997 1 2
    NRBF2 CALCOCO2 255 0 217 391 1 2
    NRBF2 RPTOR 270 0 95 311 1 2
    NRBF2 GABARAPL2 0 0 162 161 1 2
    NRBF2 ATG5 0 0 324 323 1 2
    NRBF2 PPARA 192 0 684 734 1 1
    NRBF2 ANKRD39 0 0 294 294 1 1
    NRBF2 ISG15 0 0 0 224 1 1
    NRBF2 MAP1LC3B 0 0 157 206 1 2
    NRBF2 POMP 0 0 155 154 1 1
    NRBF2 ATG10 0 0 260 260 1 2
    NRBF2 SOCS6 0 360 0 360 1 1
    NRBF2 DDA1 274 0 0 274 1 1
    NRBF2 AGPAT4 0 0 163 163 1 1
    NRBF2 TMEM120B 0 0 283 282 1 1
    NRBF2 CISH 0 360 0 360 1 1
    NRBF2 RARA 192 0 113 252 1 1
    NRBF2 IKBKG 178 0 0 177 1 1
    NRBF2 CCZ1B 0 0 155 154 1 1
    NRBF2 NAA25 0 0 215 215 1 1
    NRBF2 NISCH 0 0 205 205 1 1
    NRBF2 MED24 0 0 184 183 1 1
    NRBF2 CCBL2 0 0 195 195 1 1
    NRBF2 C5orf56 0 0 265 265 1 1
    NRBF2 PIK3R6 0 360 0 360 1 1
    NRBF2 ULK1 286 600 392 811 1 2
    NRBF2 VPS33A 0 0 218 218 1 1
    NRBF2 STXBP4 0 0 155 154 1 1
    NRBF2 TMEM81 0 0 394 394 1 1
    NRBF2 TFE3 0 0 186 187 1 1
    NRBF2 DPM3 0 0 180 179 1 1
    NRBF2 FUNDC1 0 0 172 171 1 2
    NRBF2 RAB7A 0 0 288 288 1 2
    NRBF2 PIK3C2G 0 360 0 360 1 1
    NRBF2 UTP3 0 0 209 209 1 1
    NRBF2 PDXDC1 0 0 218 218 1 1
    NRBF2 FAM169B 0 0 289 288 1 1
    NRBF2 PGPEP1 0 0 204 204 1 1
    NRBF2 RNFT2 0 0 278 278 1 1
    NRBF2 C1orf116 0 0 213 213 1 1
    NRBF2 SLC6A13 0 0 0 329 1 1
    NRBF2 SOCS1 0 360 0 360 1 1
    NRBF2 THRB 192 0 0 192 1 1
    NRBF2 ARHGAP31 0 0 203 203 1 1
    NRBF2 RB1CC1 270 800 452 916 1 2
    NRBF2 LARP1 0 0 135 156 1 1
    NRBF2 WDFY3 0 0 232 231 1 2
    NRBF2 MON1A 0 0 167 167 1 1
    NRBF2 COPZ1 0 0 400 400 1 1
    NRBF2 SOCS4 0 360 0 360 1 1
    NRBF2 UVRAG 0 0 738 738 1 2
    NRBF2 RMND1 0 0 213 213 1 1
    NRBF2 SOCS3 0 360 0 360 1 1
    NRBF2 RXRA 192 0 139 274 1 1
    NRBF2 VTCN1 0 0 164 163 1 1
    NRBF2 NPY 0 0 0 207 1 1
    NRBF2 RSG1 0 0 245 244 1 1
    NRBF2 APOL6 0 0 164 163 1 1
    NRBF2 SOGA3 454 0 0 454 1 1
    NRBF2 UNK 236 0 0 236 1 1
    NRBF2 PNRC2 0 0 181 181 1 1
    NRBF2 PIK3R2 0 360 0 360 1 1
    NRBF2 SLC6A4 0 0 0 434 1 1
    NRBF2 C5orf30 0 0 234 234 1 1
    NRBF2 NXPH4 0 0 201 201 1 1
    NRBF2 NBR1 0 0 233 232 1 2
    NRBF2 C10orf12 0 0 241 240 1 1
    NRBF2 SNAP29 0 0 243 242 1 2
    NRBF2 BECN1 870 800 731 992 1 2
    NRBF2 NTAN1 0 0 193 193 1 1
    NRBF2 SLC6A12 0 0 0 203 1 1
    NRBF2 PIK3R3 0 360 0 360 1 1
    NRBF2 AQP10 0 0 154 153 1 1
    NRBF2 GLIPR2 0 0 152 151 1 2
    NRBF2 WIPI2 0 0 426 426 1 2
    NRBF2 VAC14 0 360 53 368 1 1
    NRBF2 KIAA2026 0 0 119 254 1 1
    NRBF2 EXOSC6 0 0 151 150 1 1
    NRBF2 PIK3CA 0 360 0 360 1 2
    NRBF2 PIK3CB 0 360 0 360 1 1
    NRBF2 NRIP1 0 0 240 239 1 1
    NRBF2 TSNAXIP1 0 0 201 201 1 1
    NRBF2 ULK2 0 600 218 673 1 2
    NRBF2 ITM2C 0 0 0 250 1 1
    NRBF2 RNF113A 0 0 204 204 1 1
    NRBF2 CCDC22 0 0 158 157 1 1
    NRBF2 PIK3CG 0 360 74 382 1 1
    NRBF2 SLA2 0 360 0 360 1 1
    NRBF2 FSBP 0 0 282 397 1 1
    NRBF2 STYK1 270 0 0 270 1 1
    NRBF2 VIPAS39 0 0 181 181 1 1
    NRBF2 ATG12 0 0 298 298 1 2
    NRBF2 ATG13 0 0 401 400 1 2
    NRBF2 ABHD8 0 0 240 239 1 1
    NRBF2 SQSTM1 0 0 265 265 1 2
    NRBF2 SCOC 129 0 448 499 1 2
    NRBF2 PRR5L 0 0 164 163 1 1
    NRBF2 PLEKHD1 0 0 370 370 1 1
    NRBF2 COPRS 0 0 506 506 1 1
    NRBF2 ASZ1 0 0 184 183 1 1
    NRBF2 MRPL57 0 0 234 234 1 1
    NRBF2 GTF2I 0 0 0 171 1 1
    NRBF2 HRCT1 0 0 334 334 1 1
    NRBF2 EIF2B1 0 0 155 207 1 1
    NRBF2 CACYBP 0 0 142 308 1 1
    NRBF2 ATG101 0 600 392 746 1 2
    NRBF2 PLEKHM1 0 0 210 210 1 2
    NRBF2 TFEB 0 0 245 246 1 2
    NRBF2 CARD16 0 0 165 165 1 1
    NRBF2 TMEM258 0 0 211 211 1 1
    NRBF2 FADS1 0 0 187 187 1 1
    NRBF2 CCDC71 0 0 321 321 1 1
    NRBF2 CCDC183 217 0 0 217 1 1
    NRBF2 CD300C 0 0 180 179 1 1
    NRBF2 ZNF404 0 0 284 284 1 1
    NRBF2 SLC6A6 0 0 0 203 1 1
    NRBF2 EGR2 0 0 134 208 1 1
    NRBF2 ADAD1 0 0 320 319 1 1
    NRBF2 PIK3C2B 0 360 0 360 1 1
    NRBF2 ATG16L1 0 0 283 282 1 2
    NRBF2 TMCC2 0 0 241 240 1 1
    NRBF2 PIK3CD 0 360 0 360 1 1
    NRBF2 HUNK 0 0 171 177 1 1
    NRBF2 CWC15 0 0 161 161 1 1
    NRBF2 DENND4A 0 0 212 212 1 1
    NRBF2 NCOR1 0 0 142 161 1 1
    NRBF2 DAND5 0 0 170 169 1 1
    NRBF2 SOCS2 0 360 0 360 1 1
    NRBF2 NCOR2 0 0 161 180 1 1
    NRBF2 COPB1 0 0 556 556 1 1
    NRBF2 ALS2CR12 0 0 261 261 1 1
    NRBF2 KLHDC10 0 0 218 218 1 1
    NRBF2 KIAA1109 0 0 171 171 1 1
    NRBF2 REEP3 0 0 560 560 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0006914 Biological Process autophagy involved_in IBA
    GO:0006914 Biological Process autophagy involved_in IMP
    GO:0034976 Biological Process response to endoplasmic reticulum stress involved_in IEA
    GO:0005776 Cellular Component autophagosome located_in IEA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0031410 Cellular Component cytoplasmic vesicle located_in IEA
    GO:0005654 Cellular Component nucleoplasm located_in TAS
    GO:0035032 Cellular Component phosphatidylinositol 3-kinase complex, class III part_of IDA
    Pathways
    Name DB ID
    Generic Transcription Pathway Reactome R-HSA-212436
    Nuclear Receptor transcription pathway Reactome R-HSA-383280
    RNA Polymerase II Transcription Reactome R-HSA-73857
    Gene expression (Transcription) Reactome R-HSA-74160
    Alzheimer's disease (WP5124) WikiPathways WP5124_r123917
    Alzheimer's disease and miRNA effects (WP2059) WikiPathways WP2059_r119468
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_030759 5 mRNA transcript variant 1 NC_000010 Reference
    NM_001282405 2 mRNA transcript variant 2 NC_000010 Reference
    XM_047425132 1 mRNA transcript variant X1 NC_000010 Reference