TMEM150B

transmembrane protein 150B
General Information
Name transmembrane protein 150B
Alias
  • modulator of macroautophagy TMEM150B
  • DRAM-Related/Associated Member 3
  • hCG1651476
  • protein DRAM-3
  • tentonin 2
  • transmembrane protein 224
  • transmembrane protein LOC284417
Synonyms TTN2 DRAM3 TMEM224
Gene_family None
organism Homo sapiens
entrez_id 284417
location 19q13.42
transcript_count 18
exon_count 12
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
      Stringdb Modulator of macroautophagy TMEM150B; Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner. May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival; Belongs to the DRAM/TMEM150 family
      nextProt Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    TMEM150B BioGRID NUDT1 GeneID BioGRID Affinity Capture-MS
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TMEM150B LIMCH1 0 0 113 151 1 1
    TMEM150B SPI1 0 0 0 157 1 1
    TMEM150B NUAK1 0 0 189 357 1 1
    TMEM150B CYP1B1 0 0 180 213 1 1
    TMEM150B HSPA4 0 0 48 220 1 1
    TMEM150B TLR8 0 0 0 151 1 1
    TMEM150B HSPA6 0 0 161 181 1 1
    TMEM150B UBTD2 0 0 190 190 1 1
    TMEM150B CENPW 0 0 403 403 1 1
    TMEM150B TIFAB 0 0 0 157 1 1
    TMEM150B ZNF483 0 0 390 390 1 1
    TMEM150B BBS9 0 0 217 233 1 1
    TMEM150B LILRB2 0 0 0 151 1 1
    TMEM150B LHCGR 0 0 231 230 1 1
    TMEM150B COL4A3BP 0 0 229 435 1 1
    TMEM150B TTC7B 0 0 141 173 1 1
    TMEM150B TMEM18 0 0 245 244 1 1
    TMEM150B EIF2B4 0 0 0 189 1 1
    TMEM150B FETUB 0 0 93 155 1 1
    TMEM150B RXRG 0 0 170 169 1 1
    TMEM150B MCM8 0 0 634 634 1 1
    TMEM150B POLG 0 0 404 417 1 1
    TMEM150B RHBDL2 0 0 324 323 1 1
    TMEM150B TMEM86A 0 0 195 195 1 1
    TMEM150B TTC37 0 0 0 181 1 1
    TMEM150B UIMC1 0 0 460 499 1 1
    TMEM150B PRIM1 0 0 470 470 1 1
    TMEM150B ACER1 0 0 108 150 1 1
    TMEM150B EPB41L4B 0 0 116 204 1 1
    TMEM150B DRAM2 0 0 456 222 1 2
    TMEM150B NOBOX 0 0 140 198 1 1
    TMEM150B ZCCHC2 0 0 334 612 1 1
    TMEM150B TMEM38B 0 0 335 335 1 1
    TMEM150B HSPA1B 0 0 171 201 1 1
    TMEM150B WFIKKN2 0 0 142 187 1 1
    TMEM150B METAP1D 0 0 451 451 1 1
    TMEM150B TRPM5 0 0 172 171 1 1
    TMEM150B SUV420H2 0 0 193 207 1 1
    TMEM150B GNRH1 0 0 123 152 1 1
    TMEM150B ARHGAP36 0 0 369 369 1 1
    TMEM150B NLRP11 0 0 504 504 1 1
    TMEM150B TLK1 0 0 310 310 1 1
    TMEM150B LRAT 0 0 0 151 1 1
    TMEM150B SRD5A1 0 0 234 235 1 1
    TMEM150B CYP19A1 0 0 180 179 1 1
    TMEM150B SIGLEC1 0 0 120 209 1 1
    TMEM150B EFR3A 0 0 142 174 1 1
    TMEM150B NUAK2 0 0 0 173 1 1
    TMEM150B PPARG 0 0 113 174 1 1
    TMEM150B HSPA1L 0 0 186 215 1 1
    TMEM150B HMCES 0 0 345 599 1 1
    TMEM150B EFR3B 0 0 134 166 1 1
    TMEM150B SYCP2L 0 0 556 738 1 1
    TMEM150B IGF2R 0 0 205 205 1 1
    TMEM150B NOL4 0 0 310 309 1 1
    TMEM150B HELQ 0 0 390 407 1 1
    TMEM150B MSH5 0 0 63 178 1 1
    TMEM150B APOE 0 0 138 170 1 1
    TMEM150B OLFM2 0 0 294 294 1 1
    TMEM150B ZNF518A 0 0 391 758 1 1
    TMEM150B GALT 0 0 141 292 1 1
    TMEM150B LYZ 0 0 0 157 1 1
    TMEM150B TMEM150A 0 0 759 205 1 1
    TMEM150B DNAJB4 0 0 216 337 1 1
    TMEM150B PLEK 0 0 0 152 1 1
    TMEM150B DNAJB1 0 0 90 185 1 2
    TMEM150B PRRC2A 0 0 82 224 1 1
    TMEM150B MYBPC3 0 0 150 181 1 1
    TMEM150B BMP15 0 0 231 230 1 1
    TMEM150B KCNQ1 0 0 144 261 1 1
    TMEM150B LIN28B 0 0 243 242 1 1
    TMEM150B FSHB 0 0 340 340 1 1
    TMEM150B HSPB7 0 0 218 352 1 1
    TMEM150B IQSEC2 0 0 96 152 1 1
    TMEM150B SLC25A13 0 0 88 156 1 1
    TMEM150B CACNA2D2 0 0 216 216 1 1
    TMEM150B CTSW 0 0 234 261 1 1
    TMEM150B LDLR 0 0 113 193 1 1
    TMEM150B HELB 0 0 112 213 1 1
    TMEM150B SLC14A2 0 0 299 299 1 1
    TMEM150B CD302 0 0 216 233 1 1
    TMEM150B RRAD 0 0 166 347 1 1
    TMEM150B SESN1 0 0 143 376 1 2
    TMEM150B AMHR2 0 0 401 400 1 1
    TMEM150B EXO1 0 0 219 219 1 1
    TMEM150B BRSK1 0 0 681 681 1 1
    TMEM150B PPP1R27 0 0 280 313 1 1
    TMEM150B HK3 0 0 392 513 1 1
    TMEM150B TTN 0 0 289 288 1 1
    TMEM150B TMEM150C 0 0 681 205 1 1
    TMEM150B DRAM1 0 0 370 232 1 2
    TMEM150B MPEG1 0 0 0 245 1 1
    TMEM150B CALCOCO1 0 0 134 214 1 1
    TMEM150B GLS 0 0 0 187 1 1
    TMEM150B XIRP2 0 0 96 152 1 1
    TMEM150B TPRXL 0 0 214 214 1 1
    TMEM150B CLEC10A 0 0 0 161 1 1
    TMEM150B GLS2 0 0 134 265 1 1
    TMEM150B ANKK1 0 0 260 306 1 1
    TMEM150B WIPI2 0 0 171 171 1 2
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0006914 Biological Process autophagy involved_in IEA
    GO:0000421 Cellular Component autophagosome membrane located_in IEA
    GO:0010008 Cellular Component endosome membrane located_in IEA
    GO:0005886 Cellular Component plasma membrane is_active_in IBA
    GO:0005886 Cellular Component plasma membrane located_in IDA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_104071 2 miscRNA transcript variant 4 NC_000019 Reference
    NR_104066 2 miscRNA transcript variant 3 NC_000019 Reference
    XM_011526850 4 mRNA transcript variant X12 NC_000019 Reference
    XM_047438674 1 mRNA transcript variant X11 NC_000019 Reference
    XM_047438669 1 mRNA transcript variant X5 NC_000019 Reference
    NM_001085488 3 mRNA transcript variant 2 NC_000019 Reference
    NM_001282011 2 mRNA transcript variant 1 NC_000019 Reference
    XM_017026667 3 mRNA transcript variant X4 NC_000019 Reference
    XM_047438673 1 mRNA transcript variant X9 NC_000019 Reference
    XM_005258812 5 mRNA transcript variant X2 NC_000019 Reference
    XM_047438675 1 mRNA transcript variant X14 NC_000019 Reference
    XM_047438672 1 mRNA transcript variant X8 NC_000019 Reference
    XM_047438668 1 mRNA transcript variant X1 NC_000019 Reference
    XM_011526857 3 mRNA transcript variant X13 NC_000019 Reference
    XM_047438671 1 mRNA transcript variant X7 NC_000019 Reference
    XM_011526856 4 mRNA transcript variant X10 NC_000019 Reference
    XM_011526854 4 mRNA transcript variant X3 NC_000019 Reference
    XM_047438670 1 mRNA transcript variant X6 NC_000019 Reference