NEAT1

nuclear paraspeckle assembly transcript 1
General Information
Name nuclear paraspeckle assembly transcript 1
Alias
  • MENepsilon/beta
  • long intergenic non-protein coding RNA 84
  • nuclear enriched abundant transcript 1
  • nuclear paraspeckle assembly transcript 1 (non-protein coding)
  • trophoblast MHC class II suppressor
  • trophoblast-derived noncoding RNA
  • virus inducible non-coding RNA
Synonyms TncRNA MENepsilon/beta LINC00084 VINC TP53LC15 NCRNA00084
Gene_family Long non-coding RNAs with non-systematic symbols|MicroRNA non-coding host genes
organism Homo sapiens
entrez_id 283131
location 11q13.1
transcript_count 2
exon_count 1
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015]
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    NEAT1 BioGRID RPRD1B GeneID BioGRID Affinity Capture-RNA
    NEAT1 BioGRID HNRNPA2B1 GeneID BioGRID Affinity Capture-RNA
    NEAT1 BioGRID EGR1 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    NEAT1 BioGRID NONO GeneID BioGRID Affinity Capture-RNA
    NEAT1 BioGRID SFPQ GeneID BioGRID Affinity Capture-RNA; Co-fractionation
    NEAT1 BioGRID PINK1 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    NEAT1 BioGRID GAR1 GeneID BioGRID Protein-RNA
    NEAT1 BioGRID HACD3 GeneID BioGRID Protein-RNA
    NEAT1 BioGRID MPC2 GeneID BioGRID Protein-RNA
    NEAT1 BioGRID RIMBP2 GeneID BioGRID Protein-RNA
    NEAT1 BioGRID NEDD4L GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    NEAT1 BioGRID TUBB4B GeneID BioGRID Protein-RNA
    NEAT1 BioGRID TUBB4A GeneID BioGRID Protein-RNA
    NEAT1 BioGRID USP9X GeneID BioGRID Protein-RNA
    NEAT1 BioGRID CTSD GeneID BioGRID Protein-RNA
    NEAT1 BioGRID HNRNPH1 GeneID BioGRID Affinity Capture-RNA
    NEAT1 BioGRID YAP1 GeneID BioGRID Affinity Capture-RNA
    NEAT1 BioGRID TRAF6 GeneID BioGRID Affinity Capture-RNA; Protein-RNA
    NEAT1 BioGRID CHD4 GeneID BioGRID Affinity Capture-RNA
    NEAT1 BioGRID TRIM25 GeneID BioGRID Affinity Capture-RNA
    StringDB
    A B experiments database textmining combined score hadb nhadb
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:1905172 Molecular Function RISC complex binding enables IDA
    GO:0140463 Molecular Function chromatin-protein adaptor activity enables IDA
    GO:0035198 Molecular Function miRNA binding enables IDA
    GO:0140869 Molecular Function miRNA inhibitor activity via base-pairing enables IDA
    GO:0140693 Molecular Function molecular condensate scaffold activity enables IMP
    GO:0140693 Molecular Function molecular condensate scaffold activity enables TAS
    GO:0006325 Biological Process chromatin organization involved_in IEA
    GO:0000512 Biological Process lncRNA-mediated post-transcriptional gene silencing involved_in IDA
    GO:0035195 Biological Process miRNA-mediated post-transcriptional gene silencing involved_in IEA
    GO:0030575 Biological Process nuclear body organization involved_in IMP
    GO:0050729 Biological Process positive regulation of inflammatory response involved_in IMP
    GO:2000627 Biological Process positive regulation of miRNA catabolic process involved_in IMP
    GO:1901647 Biological Process positive regulation of synoviocyte proliferation acts_upstream_of IMP
    GO:0010793 Biological Process regulation of mRNA export from nucleus acts_upstream_of_or_within_negative_effect IMP
    GO:0016442 Cellular Component RISC complex part_of IEA
    GO:0042382 Cellular Component paraspeckles is_active_in IDA
    GO:0042382 Cellular Component paraspeckles is_active_in TAS
    Pathways
    Name DB ID
    Extrafollicular and follicular B cell activation by SARS-CoV-2 (WP5218) WikiPathways WP5218_r124690
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_131012 1 ncRNA transcript variant MENbeta NC_000011 Reference
    NR_028272 1 ncRNA transcript variant MENepsilon NC_000011 Reference