TECPR1

tectonin beta-propeller repeat containing 1
General Information
Name tectonin beta-propeller repeat containing 1
Alias
  • tectonin beta-propeller repeat-containing protein 1
Synonyms DKFZP434B0335 FLJ23419 FLJ90593 KIAA1358 -
Gene_family None
organism Homo sapiens
entrez_id 25851
location 7q21.3
transcript_count 5
exon_count 27
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]
      Stringdb Tectonin beta-propeller repeat-containing protein 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation; Belongs to the TECPR1 family
      nextProt Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    TECPR1 BioGRID ORF8 GeneID BioGRID Protein-peptide
    TECPR1 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    TECPR1 BioGRID ATG12 GeneID BioGRID Affinity Capture-MS
    TECPR1 BioGRID ATG5 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Co-purification; Reconstituted Complex; Two-hybrid
    TECPR1 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    TECPR1 BioGRID PRPF8 GeneID BioGRID Proximity Label-MS
    TECPR1 BioGRID H1-2 GeneID BioGRID Proximity Label-MS
    TECPR1 BioGRID COL18A1 GeneID BioGRID Affinity Capture-MS
    TECPR1 BioGRID MCMBP GeneID BioGRID Affinity Capture-MS
    TECPR1 BioGRID ATG3 GeneID BioGRID Affinity Capture-MS
    TECPR1 BioGRID TRAPPC11 GeneID BioGRID Affinity Capture-MS
    TECPR1 BioGRID TRAPPC12 GeneID BioGRID Affinity Capture-MS
    TECPR1 BioGRID TRAPPC8 GeneID BioGRID Affinity Capture-MS
    TECPR1 BioGRID PLOD3 GeneID BioGRID Affinity Capture-MS
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TECPR1 GABARAP 0 0 324 569 1 2
    TECPR1 ATG2B 0 0 171 195 1 2
    TECPR1 TBK1 0 0 177 177 1 2
    TECPR1 TRAPPC3 0 0 167 222 1 1
    TECPR1 SEC22C 0 0 320 425 1 1
    TECPR1 PEX11A 0 0 0 210 1 1
    TECPR1 FDXACB1 0 0 0 216 1 1
    TECPR1 ARHGAP26 0 0 113 206 1 1
    TECPR1 CCZ1 0 0 57 373 1 1
    TECPR1 PANK2 0 0 47 263 1 1
    TECPR1 WIPI1 0 800 501 896 1 2
    TECPR1 PPP2R1B 0 0 120 216 1 1
    TECPR1 CNN3 0 0 0 155 1 1
    TECPR1 RAB5A 0 0 150 298 1 2
    TECPR1 STX17 0 0 204 258 1 2
    TECPR1 RAB7B 0 0 267 267 1 1
    TECPR1 TRAPPC1 0 0 241 246 1 1
    TECPR1 AMBRA1 0 0 218 256 1 2
    TECPR1 KCTD5 0 0 0 188 1 1
    TECPR1 KBTBD6 0 0 96 150 1 1
    TECPR1 PACS2 0 0 45 150 1 1
    TECPR1 BNIP3L 0 0 179 179 1 2
    TECPR1 PEX12 0 0 0 261 1 1
    TECPR1 VAMP7 0 0 151 228 1 1
    TECPR1 MAP1LC3A 0 0 269 362 1 2
    TECPR1 PEX13 0 0 0 303 1 1
    TECPR1 LGALS8 0 0 390 431 1 1
    TECPR1 FAM134B 0 0 165 252 1 1
    TECPR1 MFN2 0 0 90 396 1 2
    TECPR1 ANO2 0 0 142 230 1 1
    TECPR1 CAMK1G 0 0 124 218 1 1
    TECPR1 ZFYVE1 0 0 212 212 1 2
    TECPR1 KIF5B 0 0 0 358 1 1
    TECPR1 MTOR 0 0 150 169 1 2
    TECPR1 ENSG00000250232 0 0 113 250 1 1
    TECPR1 ADAP1 0 0 183 345 1 1
    TECPR1 SEC24D 0 0 228 288 1 1
    TECPR1 ADNP2 0 0 174 353 1 1
    TECPR1 VTI1B 0 0 181 181 1 2
    TECPR1 MTMR3 0 0 289 333 1 2
    TECPR1 CCT3 0 0 0 189 1 1
    TECPR1 PEX2 0 0 0 260 1 1
    TECPR1 RNMTL1 0 0 212 212 1 1
    TECPR1 PEX19 0 0 0 179 1 1
    TECPR1 ATG4C 0 0 112 303 1 2
    TECPR1 NSUN5 0 0 181 311 1 1
    TECPR1 TRAPPC8 159 0 294 548 1 1
    TECPR1 ALDH3A2 0 0 0 156 1 1
    TECPR1 MAP1LC3C 0 0 496 560 1 2
    TECPR1 ATG7 0 0 391 391 1 2
    TECPR1 PEX5L 0 0 0 192 1 1
    TECPR1 ACTR2 0 0 195 282 1 1
    TECPR1 ALDH3B1 0 0 0 156 1 1
    TECPR1 ZFAND6 0 0 0 179 1 1
    TECPR1 PLEK 0 0 249 266 1 1
    TECPR1 ATG3 128 0 422 669 1 2
    TECPR1 SRCIN1 0 0 155 243 1 1
    TECPR1 FMN1 0 0 0 163 1 1
    TECPR1 TRAPPC2P1 0 0 270 270 1 1
    TECPR1 JOSD1 0 0 204 204 1 1
    TECPR1 PIK3C3 0 0 393 405 1 2
    TECPR1 ATG16L2 0 0 345 505 1 2
    TECPR1 KBTBD7 0 0 181 230 1 1
    TECPR1 TRAPPC11 159 0 447 562 1 1
    TECPR1 PINK1 0 0 140 198 1 2
    TECPR1 ATG10 0 0 422 481 1 2
    TECPR1 MAP1LC3B 0 0 180 486 1 2
    TECPR1 NETO1 0 0 158 210 1 1
    TECPR1 TPCN2 0 0 256 256 1 1
    TECPR1 LRSAM1 0 0 180 179 1 2
    TECPR1 TTLL12 0 0 236 314 1 1
    TECPR1 PEX6 0 0 0 303 1 1
    TECPR1 VPS33A 0 0 229 286 1 1
    TECPR1 IQGAP1 0 0 94 150 1 1
    TECPR1 GBAS 0 0 134 170 1 1
    TECPR1 LAMP5 0 0 182 268 1 1
    TECPR1 ULK1 0 0 341 341 1 2
    TECPR1 PEX5 0 0 0 250 1 1
    TECPR1 RNF213 0 0 0 258 1 1
    TECPR1 MAP1LC3B2 0 0 0 399 1 2
    TECPR1 CCZ1B 0 0 57 373 1 1
    TECPR1 MCCC2 0 0 0 188 1 1
    TECPR1 RPA3 0 0 0 365 1 1
    TECPR1 WASL 0 0 234 286 1 1
    TECPR1 KCTD2 0 0 74 215 1 1
    TECPR1 ALDH3B2 0 0 0 156 1 1
    TECPR1 SH3GLB1 0 0 231 273 1 2
    TECPR1 PEX11G 0 0 0 210 1 1
    TECPR1 MTMR14 0 0 170 169 1 1
    TECPR1 CNOT1 0 0 75 286 1 1
    TECPR1 SYNJ2BP-COX16 0 0 0 219 1 1
    TECPR1 PBXIP1 0 0 208 226 1 1
    TECPR1 AFF3 0 0 113 205 1 1
    TECPR1 ZNF732 0 0 171 171 1 1
    TECPR1 FARP2 0 0 175 175 1 1
    TECPR1 TRAPPC12 159 0 501 669 1 1
    TECPR1 BHMT 0 0 117 418 1 1
    TECPR1 DYSF 0 0 234 234 1 1
    TECPR1 FYCO1 57 0 336 347 1 2
    TECPR1 TOM1 0 0 113 288 1 1
    TECPR1 TRAF6 0 0 125 179 1 2
    TECPR1 TRAPPC5 0 0 248 454 1 1
    TECPR1 PIK3R4 0 0 328 329 1 2
    TECPR1 OPTN 0 0 390 391 1 2
    TECPR1 FNBP1 0 0 138 277 1 1
    TECPR1 ATG4A 0 0 162 432 1 2
    TECPR1 PCLO 0 0 106 198 1 1
    TECPR1 DFNA5 0 0 143 338 1 1
    TECPR1 GADD45B 0 0 0 302 1 1
    TECPR1 PEX11B 0 0 0 459 1 1
    TECPR1 PRR5 0 0 108 163 1 1
    TECPR1 GPS1 0 0 0 571 1 1
    TECPR1 CALCOCO2 0 0 520 520 1 2
    TECPR1 C2CD2 0 0 0 188 1 1
    TECPR1 ATG5 973 800 988 999 1 2
    TECPR1 GABARAPL2 0 0 423 629 1 2
    TECPR1 TBC1D9B 0 0 90 152 1 1
    TECPR1 TPPP 0 0 113 264 1 1
    TECPR1 VMP1 0 0 181 213 1 2
    TECPR1 PARL 0 0 141 169 1 1
    TECPR1 ATG14 0 0 369 392 1 2
    TECPR1 TRAPPC6A 0 0 233 240 1 1
    TECPR1 CHD7 0 0 0 189 1 1
    TECPR1 MPP3 0 0 123 211 1 1
    TECPR1 CHD9 0 0 0 189 1 1
    TECPR1 NOD1 0 0 282 282 1 1
    TECPR1 TECPR2 0 0 501 283 1 2
    TECPR1 NBR1 0 0 350 368 1 2
    TECPR1 WAS 0 0 147 205 1 1
    TECPR1 IRGM 0 0 213 213 1 2
    TECPR1 KIAA0226L 0 0 260 273 1 1
    TECPR1 C16orf46 0 0 151 150 1 1
    TECPR1 PEX3 0 0 0 333 1 2
    TECPR1 COL18A1 159 0 0 158 1 1
    TECPR1 ALDH18A1 0 0 0 431 1 1
    TECPR1 WIPI2 0 800 879 974 1 2
    TECPR1 MFI2 0 0 150 344 1 1
    TECPR1 ULK2 0 0 283 298 1 2
    TECPR1 PNN 0 0 54 268 1 1
    TECPR1 SLC2A4RG 0 0 203 203 1 1
    TECPR1 BECN1 64 0 390 404 1 2
    TECPR1 ZFAND5 0 0 0 179 1 1
    TECPR1 MVP 0 0 194 194 1 1
    TECPR1 SNAP29 0 0 160 256 1 2
    TECPR1 PEX16 0 0 0 333 1 1
    TECPR1 MDH1 0 0 0 157 1 1
    TECPR1 MON1B 0 0 95 151 1 1
    TECPR1 ATG4B 0 0 216 501 1 2
    TECPR1 TAX1BP1 0 0 205 254 1 2
    TECPR1 VPS39 0 0 147 293 1 1
    TECPR1 ACTA1 0 0 261 265 1 1
    TECPR1 C18orf8 0 0 0 388 1 1
    TECPR1 FNBP1L 0 0 134 188 1 1
    TECPR1 FARS2 0 0 0 216 1 1
    TECPR1 ITFG1 0 0 0 155 1 1
    TECPR1 VIPR1 0 0 459 459 1 1
    TECPR1 MFN1 0 0 43 217 1 1
    TECPR1 LNX2 0 0 0 152 1 1
    TECPR1 FUNDC1 0 0 216 216 1 2
    TECPR1 RAB7A 0 0 261 277 1 2
    TECPR1 TBC1D25 0 0 218 341 1 1
    TECPR1 DRAM1 0 0 206 328 1 2
    TECPR1 C19orf12 0 0 66 442 1 2
    TECPR1 FAM83F 0 0 271 276 1 1
    TECPR1 NCOA4 0 0 112 248 1 1
    TECPR1 PNLIPRP1 0 0 181 181 1 1
    TECPR1 SMYD3 0 0 95 160 1 1
    TECPR1 TRAPPC2 0 0 233 232 1 1
    TECPR1 PEX1 0 0 0 372 1 1
    TECPR1 CENPE 0 0 74 152 1 1
    TECPR1 AKAP8 0 0 150 172 1 1
    TECPR1 GDAP1 0 0 0 190 1 1
    TECPR1 RB1CC1 0 0 337 337 1 2
    TECPR1 VGLL3 0 0 162 193 1 1
    TECPR1 WDR45 0 0 264 378 1 2
    TECPR1 LAMP2 0 0 231 273 1 2
    TECPR1 KCNK18 0 0 150 297 1 1
    TECPR1 WDFY3 0 0 268 318 1 2
    TECPR1 TRAPPC2L 0 0 300 300 1 1
    TECPR1 UVRAG 0 0 404 441 1 2
    TECPR1 ESX1 0 0 217 223 1 1
    TECPR1 GABARAPL1 0 0 406 568 1 2
    TECPR1 VPS16 0 0 177 238 1 1
    TECPR1 LAMP1 0 0 171 171 1 2
    TECPR1 TRAPPC4 0 0 228 425 1 1
    TECPR1 SPG11 0 0 0 302 1 1
    TECPR1 RRM2 0 0 0 179 1 1
    TECPR1 TP53INP2 0 0 150 180 1 2
    TECPR1 HTT 0 0 113 156 1 1
    TECPR1 PEX14 0 0 0 260 1 2
    TECPR1 MCMBP 159 0 0 158 1 1
    TECPR1 CHD8 0 0 0 189 1 1
    TECPR1 PIK3C2B 0 0 108 201 1 1
    TECPR1 NOD2 0 0 227 226 1 1
    TECPR1 CTNNA1 0 0 97 159 1 1
    TECPR1 KIF5C 0 0 0 248 1 1
    TECPR1 TOM1L2 0 0 70 201 1 1
    TECPR1 WDR48 0 0 44 431 1 1
    TECPR1 RAB1A 0 0 186 186 1 2
    TECPR1 FER1L5 0 0 234 234 1 1
    TECPR1 ATG16L1 0 0 547 731 1 2
    TECPR1 EPG5 0 0 209 321 1 2
    TECPR1 MAP1A 0 0 141 292 1 1
    TECPR1 PRKX 0 0 0 155 1 1
    TECPR1 PAGE4 0 0 193 193 1 1
    TECPR1 ULK3 0 0 184 183 1 2
    TECPR1 RRM2B 0 0 0 179 1 1
    TECPR1 PEX7 0 0 0 260 1 1
    TECPR1 TBC1D1 0 0 113 226 1 1
    TECPR1 SCOC 0 0 194 249 1 2
    TECPR1 BNIP3 0 0 136 195 1 2
    TECPR1 SQSTM1 0 0 391 390 1 2
    TECPR1 DLG3 0 0 103 159 1 1
    TECPR1 VAMP8 0 0 193 193 1 2
    TECPR1 PTPN5 0 0 125 221 1 1
    TECPR1 ATG13 0 0 297 297 1 2
    TECPR1 ALDH3A1 0 0 0 156 1 1
    TECPR1 HDAC6 0 0 183 194 1 2
    TECPR1 ATG12 660 0 980 994 1 2
    TECPR1 MLLT3 0 0 66 268 1 1
    TECPR1 PGLYRP1 0 0 123 163 1 1
    TECPR1 ATG2A 0 0 256 322 1 2
    TECPR1 SMURF1 0 0 143 154 1 1
    TECPR1 CD300C 0 0 266 266 1 1
    TECPR1 ATG4D 0 0 183 369 1 2
    TECPR1 TFEB 0 0 150 185 1 2
    TECPR1 KIF5A 0 0 0 227 1 1
    TECPR1 PRKAR2A 0 0 135 223 1 1
    TECPR1 TRAPPC13 0 0 103 197 1 1
    TECPR1 ATG101 0 0 294 294 1 2
    TECPR1 LNX1 0 0 0 181 1 1
    TECPR1 PLEKHM1 0 0 261 307 1 2
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0032266 Molecular Function phosphatidylinositol-3-phosphate binding enables IBA
    GO:0032266 Molecular Function phosphatidylinositol-3-phosphate binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0097352 Biological Process autophagosome maturation involved_in IBA
    GO:0097352 Biological Process autophagosome maturation involved_in IMP
    GO:0006914 Biological Process autophagy involved_in IDA
    GO:0016236 Biological Process macroautophagy involved_in IMP
    GO:1901096 Biological Process regulation of autophagosome maturation involved_in IMP
    GO:0000421 Cellular Component autophagosome membrane is_active_in IBA
    GO:0000421 Cellular Component autophagosome membrane located_in IDA
    GO:0031410 Cellular Component cytoplasmic vesicle located_in IEA
    GO:0043231 Cellular Component intracellular membrane-bounded organelle located_in IDA
    GO:0005765 Cellular Component lysosomal membrane is_active_in IBA
    GO:0005765 Cellular Component lysosomal membrane located_in IDA
    GO:0005654 Cellular Component nucleoplasm located_in IDA
    GO:0032991 Cellular Component protein-containing complex part_of NAS
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XR_428174 4 miscRNA transcript variant X4 NC_000007 Reference
    XM_047420119 1 mRNA transcript variant X3 NC_000007 Reference
    XM_005250253 5 mRNA transcript variant X1 NC_000007 Reference
    XM_017011937 2 mRNA transcript variant X2 NC_000007 Reference
    NM_015395 3 mRNA None NC_000007 Reference