TAB3

TGF-beta activated kinase 1 (MAP3K7) binding protein 3
General Information
Name TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Alias
  • TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
  • NF-kappa-B-activating protein 1
  • NFkB activating protein 1
  • TAB-3
  • TAK1-binding protein 3
  • TGF-beta activated kinase 1 and MAP3K7 binding protein 3
  • TGF-beta-activated kinase 1-binding protein 3
  • mitogen-activated protein kinase kinase kinase 7 interacting protein 3
Synonyms MAP3K7IP3 NAP1
Gene_family Zinc fingers RANBP2-type
organism Homo sapiens
entrez_id 257397
location Xp21.2
transcript_count 12
exon_count 15
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
      Stringdb TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor; Zinc fingers RANBP2-type
      nextProt Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:22158122).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    TAB3 BioGRID CDC123 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID UBC GeneID BioGRID Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
    TAB3 BioGRID ORF1ab GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID WWTR1 GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID UBE2H GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID EYA4 GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID MAP3K7 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    TAB3 BioGRID AMFR GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Co-localization
    TAB3 BioGRID Traip GeneID BioGRID Two-hybrid
    TAB3 BioGRID TRAF6 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    TAB3 BioGRID YWHAQ GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID YWHAZ GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID YWHAH GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    TAB3 BioGRID YWHAG GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID SFN GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID TRIM38 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID ZRANB1 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID LATS1 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID ORF6 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID PRMT1 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID SNX27 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID RNF43 GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID ETV6 GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID TRIM27 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID TAB2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    TAB3 BioGRID NOMO3 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID EMILIN1 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID WWP2 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID TAB1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    TAB3 BioGRID UBQLN2 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID AKAP1 GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID STAT3 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TAB3 BioGRID YWHAE GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID IFI16 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID USP15 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID NBR1 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID MAP3K7CL GeneID BioGRID Two-hybrid
    TAB3 BioGRID YAP1 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID BICD2 GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID BICD1 GeneID BioGRID Proximity Label-MS
    TAB3 BioGRID PPIL3 GeneID BioGRID Affinity Capture-Western; Protein-peptide; Reconstituted Complex
    TAB3 BioGRID OGT GeneID BioGRID Biochemical Activity
    TAB3 BioGRID SNAI1 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID RNF31 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID TNF GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID NLRP6 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID CYLD GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID CARD11 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID IKBKB GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID PBXIP1 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID RNF4 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID ESR1 GeneID BioGRID Affinity Capture-MS
    TAB3 BioGRID ptpA GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    TAB3 BioGRID IKBKG GeneID BioGRID Reconstituted Complex
    TAB3 BioGRID CEP57L1 GeneID BioGRID Two-hybrid
    TAB3 BioGRID PIN1 GeneID BioGRID Two-hybrid
    TAB3 BioGRID DYNC2I2 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    TAB3 BioGRID TRIM5 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID ATG13 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID ATG5 GeneID BioGRID Co-localization
    TAB3 BioGRID BECN1 GeneID BioGRID Affinity Capture-Western; Co-localization
    TAB3 BioGRID SMAD7 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID Trim30a GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID RBCK1 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID CALCOCO2 GeneID BioGRID Affinity Capture-Western
    TAB3 Protein MAP3K7CL GeneID HPRD None
    TAB3 Protein TAB1 GeneID HPRD None
    TAB3 Protein TRAF6 GeneID HPRD None
    TAB3 Protein TRAF2 GeneID HPRD None
    TAB3 BioGRID TRAF2 GeneID BioGRID Affinity Capture-Western
    TAB3 BioGRID TAB3 GeneID BioGRID Affinity Capture-Western
    TAB3 Protein TRAF6 GeneID BIND TAB3 interacts with TRAF6.
    TAB3 Protein IKBKG GeneID BIND TAB3 interacts with NEMO.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TAB3 MAPK10 0 0 96 171 1 2
    TAB3 E2F3 0 0 124 187 1 1
    TAB3 UBA52 0 650 0 650 1 1
    TAB3 UIMC1 0 0 167 174 1 1
    TAB3 ABCB7 0 0 0 301 1 1
    TAB3 EP300 0 0 74 280 1 1
    TAB3 MAPK14 0 650 245 732 1 1
    TAB3 NXF5 0 0 0 152 1 1
    TAB3 PHF6 0 0 0 282 1 1
    TAB3 NFKBIA 0 650 504 820 1 1
    TAB3 PPEF1 0 0 0 197 1 1
    TAB3 MLLT4 0 0 511 511 1 1
    TAB3 APOOL 0 0 0 266 1 1
    TAB3 SYK 0 0 92 151 1 1
    TAB3 MBNL3 0 0 0 279 1 1
    TAB3 ZC3H12A 0 0 202 219 1 1
    TAB3 BIRC3 0 600 223 740 1 1
    TAB3 MAP3K3 0 0 367 380 1 1
    TAB3 NKAP 0 0 90 286 1 1
    TAB3 GABRQ 0 0 0 153 1 1
    TAB3 CASP8 0 0 326 334 1 2
    TAB3 TRAF7 0 0 161 277 1 1
    TAB3 OTULIN 0 0 293 293 1 1
    TAB3 TRIM62 0 0 95 187 1 1
    TAB3 PCMT1 0 0 147 392 1 1
    TAB3 RRAGB 0 0 0 248 1 2
    TAB3 KLHL4 0 0 0 215 1 1
    TAB3 BBS10 0 0 0 203 1 1
    TAB3 DSTYK 0 0 96 301 1 1
    TAB3 CUL1 0 0 123 181 1 1
    TAB3 SNIP1 0 0 66 221 1 1
    TAB3 NUP62CL 0 0 0 152 1 1
    TAB3 NYX 0 0 0 150 1 1
    TAB3 KDM5C 0 0 66 168 1 1
    TAB3 NLRP6 270 0 112 333 1 1
    TAB3 ZNF436 0 0 286 286 1 1
    TAB3 ACSL4 0 0 0 157 1 1
    TAB3 TENM1 0 0 0 323 1 1
    TAB3 TAF1L 0 0 45 188 1 1
    TAB3 KIAA1467 0 0 161 161 1 1
    TAB3 RNF31 118 0 518 556 1 1
    TAB3 IRAK4 0 600 602 849 1 1
    TAB3 SLC25A43 0 0 0 270 1 1
    TAB3 UBE2S 0 0 194 202 1 1
    TAB3 MTDH 0 0 171 189 1 2
    TAB3 IL10 0 0 205 205 1 1
    TAB3 OPHN1 0 0 0 260 1 1
    TAB3 PRPS1 0 0 0 153 1 1
    TAB3 TRADD 0 600 560 827 1 1
    TAB3 BMP10 0 0 45 366 1 1
    TAB3 OTUD5 0 0 203 220 1 1
    TAB3 TRAT1 0 0 325 325 1 1
    TAB3 DMD 0 0 0 267 1 1
    TAB3 TGFBR2 0 0 90 183 1 1
    TAB3 MAVS 0 0 265 265 1 1
    TAB3 KIAA1210 0 0 0 215 1 1
    TAB3 IL1A 0 0 162 161 1 1
    TAB3 BHLHB9 0 0 0 156 1 1
    TAB3 MAP7D3 0 0 0 223 1 1
    TAB3 CDK6 0 0 155 156 1 1
    TAB3 DDX41 0 0 142 167 1 1
    TAB3 DDX58 0 0 346 351 1 1
    TAB3 GPR174 0 0 0 153 1 1
    TAB3 OGT 270 0 50 349 1 1
    TAB3 ATP1B4 0 0 0 220 1 1
    TAB3 MAPKAPK2 0 0 140 199 1 1
    TAB3 POLR3G 0 0 154 183 1 1
    TAB3 VCPIP1 0 0 0 180 1 1
    TAB3 ZEB2 0 0 57 150 1 1
    TAB3 RAB41 0 0 0 294 1 1
    TAB3 TRIM21 0 0 292 379 1 1
    TAB3 ATP7B 0 0 0 209 1 1
    TAB3 RAB6C 0 0 0 294 1 1
    TAB3 ZNF763 0 0 286 286 1 1
    TAB3 MAPK8 0 0 267 312 1 2
    TAB3 AMOT 0 0 42 307 1 1
    TAB3 UPRT 0 0 0 325 1 1
    TAB3 NONO 0 0 67 155 1 1
    TAB3 MAP7D2 0 0 0 157 1 1
    TAB3 OSBPL9 0 0 75 191 1 1
    TAB3 CSNK2B 0 0 53 234 1 1
    TAB3 IKBKG 486 600 681 936 1 1
    TAB3 RAB6A 0 0 57 305 1 1
    TAB3 TXLNG 0 0 0 261 1 1
    TAB3 MAP2K4 0 900 246 925 1 1
    TAB3 MAP3K12 0 0 0 288 1 1
    TAB3 HEMK1 0 0 181 181 1 1
    TAB3 IFIH1 0 0 240 239 1 1
    TAB3 NFKBIB 0 0 211 333 1 1
    TAB3 MTMR8 0 0 0 278 1 1
    TAB3 PCDH11X 0 0 0 237 1 1
    TAB3 SLC15A3 0 0 134 173 1 1
    TAB3 DIABLO 0 0 233 232 1 1
    TAB3 CXorf38 0 0 0 256 1 1
    TAB3 PIAS3 0 0 161 167 1 1
    TAB3 UBC 873 650 160 962 1 1
    TAB3 PAK3 0 0 81 207 1 1
    TAB3 PIGA 0 0 0 325 1 1
    TAB3 OTUB1 0 0 181 181 1 1
    TAB3 HHAT 0 0 0 258 1 1
    TAB3 MBTPS2 0 0 0 331 1 1
    TAB3 TIFAB 0 0 134 221 1 1
    TAB3 TBC1D8B 0 0 0 167 1 1
    TAB3 DLEU7 0 0 95 365 1 1
    TAB3 TGFBR1 0 0 108 206 1 1
    TAB3 ATP6AP2 0 0 0 167 1 1
    TAB3 MOB3C 0 0 0 181 1 1
    TAB3 TRIM5 270 0 527 671 1 2
    TAB3 IRF1 0 0 140 163 1 1
    TAB3 ALPK1 0 600 0 600 1 1
    TAB3 HIPK2 0 0 0 266 1 1
    TAB3 C2orf68 0 0 202 207 1 1
    TAB3 MCF2 0 0 0 222 1 1
    TAB3 FAM46D 0 0 0 319 1 1
    TAB3 DIAPH2 0 0 0 327 1 1
    TAB3 TLR8 0 0 241 280 1 1
    TAB3 NKAPL 0 0 113 203 1 1
    TAB3 ATG5 273 0 141 348 1 2
    TAB3 MAP2K6 0 900 324 931 1 1
    TAB3 CALCOCO2 270 0 97 328 1 2
    TAB3 PDCD4 0 0 90 154 1 1
    TAB3 ARSF 0 0 0 156 1 1
    TAB3 XPO5 0 0 106 161 1 1
    TAB3 CACUL1 0 0 0 183 1 1
    TAB3 RPS6KA3 0 0 0 328 1 1
    TAB3 COPS5 0 0 134 160 1 1
    TAB3 UBE2D2 0 0 154 172 1 1
    TAB3 YIPF6 0 0 0 266 1 1
    TAB3 ZNF7 0 0 268 268 1 1
    TAB3 IRF5 0 0 242 241 1 1
    TAB3 MAPK9 0 0 163 234 1 2
    TAB3 IFNB1 0 0 390 390 1 1
    TAB3 MAPK6 0 0 87 238 1 1
    TAB3 ESR1 270 0 88 316 1 1
    TAB3 TLR7 0 0 318 420 1 1
    TAB3 UBQLN2 0 0 47 214 1 2
    TAB3 HMGN5 0 0 0 151 1 1
    TAB3 ATG4A 0 0 0 243 1 2
    TAB3 MAGEB4 0 0 124 206 1 1
    TAB3 MAZ 0 0 45 437 1 1
    TAB3 MAP3K5 0 0 167 168 1 1
    TAB3 OPTN 0 0 166 165 1 2
    TAB3 SMAD7 270 0 451 582 1 1
    TAB3 TRAF6 753 800 855 993 1 2
    TAB3 PDZRN3 0 0 0 174 1 1
    TAB3 RBM10 0 0 54 167 1 1
    TAB3 PELI1 0 0 181 265 1 1
    TAB3 ELF4 0 0 82 298 1 1
    TAB3 GEMIN8 0 0 0 328 1 1
    TAB3 FAM122B 0 0 0 156 1 1
    TAB3 PCSK1 0 0 134 165 1 1
    TAB3 IL17A 0 0 244 243 1 1
    TAB3 TRMT2B 0 0 0 156 1 1
    TAB3 NOX1 0 0 56 189 1 1
    TAB3 PBXIP1 270 0 0 270 1 1
    TAB3 DOCK11 0 0 0 159 1 1
    TAB3 BCOR 0 0 0 266 1 1
    TAB3 CASP1 0 0 218 227 1 2
    TAB3 RASA4B 0 0 181 181 1 1
    TAB3 TLR6 0 0 210 222 1 1
    TAB3 ALG13 0 0 0 331 1 1
    TAB3 SNAP29 0 0 57 203 1 2
    TAB3 OTUD7B 0 900 256 933 1 1
    TAB3 CAMK2B 0 0 54 199 1 1
    TAB3 TRIM38 270 0 228 423 1 1
    TAB3 BECN1 486 0 971 985 1 2
    TAB3 TRAF3 0 800 517 926 1 2
    TAB3 TOLLIP 0 0 263 424 1 1
    TAB3 LRRK2 0 0 74 155 1 2
    TAB3 MAP2K3 0 900 336 932 1 1
    TAB3 TLR2 0 0 284 295 1 1
    TAB3 TAOK1 0 0 66 294 1 1
    TAB3 MST4 0 0 57 160 1 1
    TAB3 PNPLA4 0 0 0 183 1 1
    TAB3 CXorf58 0 0 0 244 1 1
    TAB3 SPRYD7 0 0 135 158 1 1
    TAB3 MAPK11 0 650 91 674 1 1
    TAB3 ALPK2 0 0 157 209 1 1
    TAB3 EIF1AX 0 0 0 223 1 1
    TAB3 TBKBP1 0 0 218 218 1 1
    TAB3 ENSG00000173366 0 0 310 320 1 1
    TAB3 PFKFB1 0 0 0 169 1 1
    TAB3 MAPK12 0 650 101 697 1 1
    TAB3 RBMX 0 0 0 185 1 1
    TAB3 CTPS2 0 0 108 379 1 1
    TAB3 TRIM17 0 0 212 275 1 2
    TAB3 SLC9A7 0 0 63 335 1 1
    TAB3 EIF2S3 0 0 0 198 1 1
    TAB3 TNIP3 0 0 181 191 1 1
    TAB3 CARD11 270 0 352 512 1 1
    TAB3 TAF1 0 0 45 301 1 1
    TAB3 ZNF629 0 0 287 286 1 1
    TAB3 NOD1 0 600 327 721 1 1
    TAB3 TRIM11 0 0 112 156 1 1
    TAB3 JUN 0 0 310 329 1 1
    TAB3 SHARPIN 0 0 457 461 1 1
    TAB3 ENOX2 0 0 0 250 1 1
    TAB3 OTC 0 0 0 183 1 1
    TAB3 YWHAE 0 0 396 396 1 1
    TAB3 RPL39 0 0 90 165 1 1
    TAB3 LAMP2 0 0 0 181 1 2
    TAB3 JADE3 0 0 123 375 1 1
    TAB3 NFKBIE 0 0 163 163 1 1
    TAB3 TICAM1 0 600 391 766 1 1
    TAB3 ARMCX5 0 0 0 177 1 1
    TAB3 CYSLTR1 0 0 0 183 1 1
    TAB3 ZNF157 0 0 0 181 1 1
    TAB3 SIGIRR 0 0 107 176 1 1
    TAB3 TNIP1 0 0 261 334 1 1
    TAB3 IRAK3 0 0 308 353 1 1
    TAB3 TIFA 0 600 0 602 1 1
    TAB3 SPATA2L 0 0 68 223 1 1
    TAB3 TNIP2 0 0 261 261 1 1
    TAB3 TRAPPC2 0 0 0 270 1 1
    TAB3 DUSP22 0 0 83 154 1 1
    TAB3 TRPC5 0 0 0 284 1 1
    TAB3 CXorf56 0 0 0 183 1 1
    TAB3 MED12 0 0 0 202 1 1
    TAB3 USP4 0 900 195 935 1 1
    TAB3 TBL1X 0 0 67 196 1 1
    TAB3 DACH2 0 0 0 181 1 1
    TAB3 BTRC 0 0 266 282 1 1
    TAB3 FUNDC1 0 0 0 244 1 2
    TAB3 RAP2C 0 0 0 211 1 1
    TAB3 FRMPD4 0 0 0 254 1 1
    TAB3 APOO 0 0 0 157 1 1
    TAB3 MID2 0 0 69 213 1 1
    TAB3 SMS 0 0 0 213 1 1
    TAB3 NCOA3 0 0 96 156 1 1
    TAB3 TNFRSF13C 0 0 166 165 1 1
    TAB3 RP2 0 0 0 325 1 1
    TAB3 RIPK2 0 800 295 862 1 1
    TAB3 CA5B 0 0 0 560 1 1
    TAB3 CSTF2 0 0 97 220 1 1
    TAB3 NKRF 0 0 45 242 1 1
    TAB3 PPP6C 0 0 170 169 1 1
    TAB3 GK 0 0 53 320 1 1
    TAB3 POGLUT1 0 0 74 150 1 1
    TAB3 CENPI 0 0 0 152 1 1
    TAB3 RPS27A 270 650 210 784 1 1
    TAB3 CHUK 0 900 675 973 1 1
    TAB3 CXorf23 0 0 0 337 1 1
    TAB3 TLR5 0 0 248 259 1 1
    TAB3 COL4A5 0 0 0 153 1 1
    TAB3 NPLOC4 0 0 528 558 1 1
    TAB3 WNT2 0 0 0 243 1 1
    TAB3 UBE2N 0 600 642 852 1 1
    TAB3 IL1RAP 0 0 161 178 1 1
    TAB3 SESTD1 0 0 464 699 1 1
    TAB3 BCL10 0 0 297 297 1 1
    TAB3 MLKL 0 0 294 400 1 1
    TAB3 ZRANB3 0 0 174 192 1 1
    TAB3 IL13RA1 0 0 49 178 1 1
    TAB3 ZRSR2 0 0 0 248 1 1
    TAB3 CNKSR2 0 0 0 267 1 1
    TAB3 NOD2 0 600 334 722 1 1
    TAB3 ECSIT 0 0 157 244 1 1
    TAB3 XKR8 0 0 56 154 1 1
    TAB3 CPNE1 0 0 102 158 1 1
    TAB3 BCORL1 0 0 0 186 1 1
    TAB3 WWC3 0 0 0 232 1 1
    TAB3 HDAC1 0 0 432 432 1 2
    TAB3 MID1 0 0 123 277 1 1
    TAB3 TRIM68 0 0 108 165 1 1
    TAB3 RIPK1 0 800 647 931 1 1
    TAB3 YWHAH 182 0 0 181 1 1
    TAB3 ZNF711 0 0 246 337 1 1
    TAB3 SLC25A14 0 0 0 185 1 1
    TAB3 REL 0 0 322 371 1 1
    TAB3 LNX1 0 0 0 174 1 1
    TAB3 NLRP3 0 0 204 204 1 2
    TAB3 CHIC1 0 0 0 336 1 1
    TAB3 NHS 0 0 0 321 1 1
    TAB3 UBE2V1 0 600 603 849 1 1
    TAB3 MAGEC3 0 0 0 181 1 1
    TAB3 TGFBR3 0 0 66 224 1 1
    TAB3 SPIN3 0 0 0 321 1 1
    TAB3 CASP3 0 0 150 173 1 2
    TAB3 DYRK2 0 0 51 174 1 1
    TAB3 CRP 0 0 0 188 1 1
    TAB3 PRKCQ 0 600 74 622 1 2
    TAB3 ACTB 0 0 155 154 1 1
    TAB3 STS 0 0 0 152 1 1
    TAB3 ATG13 270 0 73 294 1 2
    TAB3 NLRX1 0 0 139 178 1 1
    TAB3 USP11 0 0 47 163 1 1
    TAB3 RPS6KA6 0 0 0 282 1 1
    TAB3 CD40 0 0 286 329 1 1
    TAB3 TNFSF13B 0 0 192 192 1 1
    TAB3 RFK 0 0 135 170 1 1
    TAB3 TIPARP 0 0 0 188 1 1
    TAB3 NR2C2 0 0 539 556 1 1
    TAB3 TRPC4 0 0 0 152 1 1
    TAB3 MAPK3 0 0 195 195 1 2
    TAB3 RNF151 0 0 0 174 1 1
    TAB3 MPND 0 0 90 165 1 1
    TAB3 EDA2R 0 0 0 312 1 1
    TAB3 TRIM22 0 0 206 369 1 1
    TAB3 TRIM56 0 0 293 380 1 1
    TAB3 VSIG1 0 0 0 157 1 1
    TAB3 RIPK3 0 0 297 395 1 1
    TAB3 TRIM13 0 0 125 181 1 2
    TAB3 EPHA2 0 0 72 172 1 1
    TAB3 UPF3B 0 0 0 202 1 1
    TAB3 CDKL5 0 0 0 214 1 1
    TAB3 USP7 0 0 150 187 1 1
    TAB3 PPIL3 270 0 96 311 1 1
    TAB3 IKBKE 0 0 202 337 1 1
    TAB3 TRIM29 0 0 96 190 1 1
    TAB3 NUSAP1 0 0 57 213 1 1
    TAB3 WNT2B 0 0 0 243 1 1
    TAB3 TGFBRAP1 0 0 70 448 1 1
    TAB3 HACE1 0 0 134 217 1 1
    TAB3 LPAR4 0 0 0 154 1 1
    TAB3 IL1B 0 0 403 403 1 1
    TAB3 STX17 0 0 81 266 1 2
    TAB3 TRAF5 0 600 469 815 1 1
    TAB3 TRIM27 0 0 292 314 1 1
    TAB3 ACOT9 0 0 0 315 1 1
    TAB3 MGST1 0 0 0 211 1 1
    TAB3 NFKBID 0 0 171 171 1 1
    TAB3 TRIM14 0 0 81 399 1 1
    TAB3 SYTL5 0 0 0 252 1 1
    TAB3 CXCL8 0 0 297 297 1 1
    TAB3 RAB6B 0 0 88 328 1 1
    TAB3 MAPK13 0 650 90 682 1 1
    TAB3 RNF11 0 0 188 205 1 1
    TAB3 MCTS1 0 0 0 151 1 1
    TAB3 TICAM2 0 600 212 689 1 1
    TAB3 CHM 0 0 0 175 1 1
    TAB3 TBK1 0 0 334 395 1 2
    TAB3 IL6 0 0 323 323 1 1
    TAB3 WDR34 270 0 766 821 1 1
    TAB3 KBTBD7 0 0 129 202 1 1
    TAB3 BRWD3 0 0 0 298 1 1
    TAB3 SEPT6 0 0 0 155 1 1
    TAB3 NLRC3 0 0 139 219 1 1
    TAB3 CXorf57 0 0 0 174 1 1
    TAB3 HDHD1 0 0 0 183 1 1
    TAB3 VAV2 0 0 137 173 1 1
    TAB3 MAP3K2 0 0 134 242 1 1
    TAB3 UBE2A 0 0 74 475 1 1
    TAB3 PARP9 0 0 0 165 1 1
    TAB3 BIRC6 0 0 73 150 1 1
    TAB3 TLR3 0 600 405 755 1 1
    TAB3 TNFRSF1A 0 600 548 811 1 1
    TAB3 UTP14A 0 0 0 223 1 1
    TAB3 BCL2L2-PABPN1 0 0 171 171 1 1
    TAB3 STAT1 0 0 160 159 1 1
    TAB3 CD40LG 0 0 150 257 1 1
    TAB3 ARAF 0 0 0 178 1 1
    TAB3 GPR112 0 0 0 267 1 1
    TAB3 SRC 0 0 108 166 1 1
    TAB3 TRAPPC8 0 0 81 228 1 1
    TAB3 COX7B2 0 0 0 179 1 1
    TAB3 MOSPD1 0 0 0 268 1 1
    TAB3 TRAF4 0 0 216 325 1 1
    TAB3 USP21 0 900 97 911 1 1
    TAB3 BMP3 0 0 46 219 1 1
    TAB3 USP2 0 900 145 914 1 1
    TAB3 TRIM59 0 0 92 173 1 1
    TAB3 KDM6A 0 0 47 402 1 1
    TAB3 SYAP1 0 0 0 178 1 1
    TAB3 TMEM164 0 0 180 327 1 1
    TAB3 BBOX1 0 0 261 277 1 1
    TAB3 IRF3 0 0 415 414 1 1
    TAB3 AMOTL1 0 0 0 151 1 1
    TAB3 KLHL15 0 0 0 266 1 1
    TAB3 RBMX2 0 0 0 181 1 1
    TAB3 RPS3 0 0 150 181 1 1
    TAB3 RS1 0 0 0 154 1 1
    TAB3 PLAGL1 0 0 45 192 1 1
    TAB3 EMILIN1 229 0 0 228 1 1
    TAB3 AIFM1 0 0 0 154 1 1
    TAB3 UBE2B 0 0 0 179 1 1
    TAB3 MAP3K1 0 0 282 299 1 1
    TAB3 MAGEB1 0 0 210 312 1 1
    TAB3 ZFX 0 0 0 325 1 1
    TAB3 HDX 0 0 0 328 1 1
    TAB3 IL1RAPL1 0 0 74 290 1 1
    TAB3 KRBOX4 0 0 0 325 1 1
    TAB3 CXorf21 0 0 391 413 1 1
    TAB3 MAP3K7CL 740 0 0 740 1 1
    TAB3 TLR9 0 0 319 329 1 1
    TAB3 PHEX 0 0 0 237 1 1
    TAB3 CREBBP 0 0 90 247 1 1
    TAB3 LRSAM1 0 0 81 157 1 2
    TAB3 USP25 0 0 171 208 1 1
    TAB3 POLA1 0 0 49 426 1 1
    TAB3 UBE2D3 0 0 183 200 1 1
    TAB3 GRB10 0 0 74 216 1 1
    TAB3 MALT1 0 650 324 756 1 1
    TAB3 ARHGEF6 0 0 0 177 1 1
    TAB3 PHF20 0 0 645 645 1 1
    TAB3 CYLD 0 900 519 953 1 1
    TAB3 STAG2 0 0 0 279 1 1
    TAB3 PIN4 0 0 0 213 1 1
    TAB3 USP9X 0 0 146 438 1 1
    TAB3 SH3KBP1 0 0 0 219 1 1
    TAB3 MED14 0 0 0 272 1 1
    TAB3 AP1S2 0 0 0 183 1 1
    TAB3 HIBCH 0 0 0 208 1 1
    TAB3 ZNF41 0 0 0 319 1 1
    TAB3 THOC2 0 0 0 285 1 1
    TAB3 OTUD7A 0 0 0 177 1 1
    TAB3 GZMM 0 0 240 239 1 1
    TAB3 BIRC2 0 600 519 809 1 1
    TAB3 GAPDH 0 0 156 155 1 2
    TAB3 ATG14 0 0 112 247 1 2
    TAB3 PHKA2 0 0 0 223 1 1
    TAB3 TLR4 0 600 391 749 1 1
    TAB3 PML 0 0 151 169 1 1
    TAB3 XIAP 0 600 293 770 1 1
    TAB3 PDK3 0 0 0 270 1 1
    TAB3 MAP2K7 0 900 135 919 1 1
    TAB3 CRIM1 0 0 57 237 1 1
    TAB3 ATP7A 0 0 42 321 1 1
    TAB3 UBE2V2 0 0 124 258 1 1
    TAB3 NLRC4 0 0 162 161 1 2
    TAB3 IKBKB 270 900 606 972 1 1
    TAB3 BMX 0 0 0 162 1 1
    TAB3 CD14 0 600 0 600 1 1
    TAB3 PDHA1 0 0 0 155 1 1
    TAB3 FANCB 0 0 0 319 1 1
    TAB3 TLR10 0 0 138 185 1 1
    TAB3 ZRANB1 0 0 340 484 1 1
    TAB3 TRIM25 0 0 297 354 1 1
    TAB3 ATF4 0 0 46 192 1 2
    TAB3 CD4 0 0 193 193 1 1
    TAB3 WIF1 0 0 0 183 1 1
    TAB3 UBE3A 0 0 141 180 1 1
    TAB3 TNKS1BP1 0 0 167 270 1 1
    TAB3 RELA 0 650 333 761 1 1
    TAB3 AKT1 0 0 195 247 1 2
    TAB3 LY96 0 600 193 669 1 1
    TAB3 NFKB1 0 650 180 719 1 1
    TAB3 RNF135 0 0 136 153 1 1
    TAB3 SLC7A11 0 0 81 155 1 1
    TAB3 USP15 270 0 181 474 1 1
    TAB3 NXT2 0 0 0 185 1 1
    TAB3 FMR1 0 0 0 164 1 1
    TAB3 ITCH 0 0 217 234 1 1
    TAB3 TAB1 863 800 906 997 1 1
    TAB3 DDX3X 0 0 86 432 1 1
    TAB3 OFD1 0 0 0 201 1 1
    TAB3 TRAF2 270 800 393 917 1 1
    TAB3 SLC15A4 0 0 139 198 1 1
    TAB3 IGBP1 0 0 0 192 1 1
    TAB3 RBBP7 0 0 0 177 1 1
    TAB3 MEFV 0 0 171 187 1 2
    TAB3 REPS2 0 0 0 232 1 1
    TAB3 CPXCR1 0 0 0 156 1 1
    TAB3 ZDHHC9 0 0 0 154 1 1
    TAB3 SSC4D 0 0 64 162 1 1
    TAB3 IL18 0 0 185 185 1 1
    TAB3 IFNA1 0 0 210 210 1 1
    TAB3 VPS36 0 0 210 218 1 1
    TAB3 WDR44 0 0 0 243 1 1
    TAB3 MYC 0 0 202 202 1 2
    TAB3 ATP11C 0 0 0 323 1 1
    TAB3 IKBKAP 0 0 52 376 1 1
    TAB3 HIPK1 0 0 0 189 1 1
    TAB3 IL1R1 0 0 450 479 1 1
    TAB3 HIPK3 0 0 0 181 1 1
    TAB3 UBE2D1 0 0 265 272 1 1
    TAB3 YBX1 270 0 0 298 1 1
    TAB3 NBR1 270 0 97 312 1 2
    TAB3 TANK 0 0 368 431 1 1
    TAB3 RNF4 270 0 108 321 1 1
    TAB3 TNF 270 600 409 820 1 1
    TAB3 TRIM33 0 0 0 199 1 1
    TAB3 IGF1R 0 0 87 165 1 1
    TAB3 TIRAP 0 0 466 505 1 1
    TAB3 TAB2 608 800 989 938 1 1
    TAB3 CPSF7 0 0 162 290 1 1
    TAB3 UVRAG 0 0 57 221 1 2
    TAB3 IRF7 0 0 341 341 1 1
    TAB3 SOCS1 0 0 232 231 1 1
    TAB3 RNF41 0 0 117 240 1 1
    TAB3 TLR1 0 0 252 263 1 1
    TAB3 GLRA2 0 0 0 214 1 1
    TAB3 MAP3K8 0 0 294 365 1 1
    TAB3 C19orf73 0 0 310 309 1 1
    TAB3 AMMECR1 0 0 0 323 1 1
    TAB3 CYLC1 0 0 0 325 1 1
    TAB3 DHX58 0 0 170 169 1 1
    TAB3 SCML2 0 0 0 278 1 1
    TAB3 RBCK1 270 0 413 568 1 1
    TAB3 GRPR 0 0 0 167 1 1
    TAB3 G3BP1 0 0 0 152 1 1
    TAB3 CASK 0 0 0 566 1 1
    TAB3 USP19 0 0 120 173 1 1
    TAB3 RELB 0 0 323 323 1 2
    TAB3 UBA1 0 0 165 348 1 1
    TAB3 USP26 0 0 74 236 1 1
    TAB3 MOSPD2 0 0 0 265 1 1
    TAB3 ADAMDEC1 0 0 161 161 1 1
    TAB3 GCSAM 0 0 92 186 1 1
    TAB3 MAGEB3 0 0 174 240 1 1
    TAB3 CLCN4 0 0 0 268 1 1
    TAB3 SMAD4 0 0 155 154 1 1
    TAB3 SHROOM2 0 0 0 161 1 1
    TAB3 PDZRN4 0 0 0 174 1 1
    TAB3 FLNA 0 0 0 189 1 1
    TAB3 ZNF501 0 0 286 286 1 1
    TAB3 CUL4B 0 0 0 347 1 1
    TAB3 UBD 0 0 391 401 1 1
    TAB3 VPS39 0 0 0 229 1 1
    TAB3 ASB11 0 0 0 325 1 1
    TAB3 MAP3K14 0 800 54 812 1 1
    TAB3 TAX1BP1 0 0 181 207 1 2
    TAB3 IREB2 0 0 150 216 1 1
    TAB3 NR0B1 0 0 123 190 1 1
    TAB3 TNFAIP3 0 900 265 934 1 1
    TAB3 ZNF280C 0 0 180 373 1 1
    TAB3 TCP1 0 0 0 203 1 1
    TAB3 NFKB2 0 0 324 323 1 1
    TAB3 TRAF1 0 0 277 377 1 1
    TAB3 MOB3B 0 0 91 338 1 1
    TAB3 FAM122C 0 0 0 265 1 1
    TAB3 RBM41 0 0 0 565 1 1
    TAB3 RAF1 0 0 81 160 1 2
    TAB3 ZNF569 0 0 283 282 1 1
    TAB3 DCAF12L1 0 0 0 258 1 1
    TAB3 CXorf22 0 0 0 282 1 1
    TAB3 IRAK1 0 600 685 886 1 1
    TAB3 NFKBIZ 0 0 172 171 1 1
    TAB3 IRAK2 0 600 517 814 1 1
    TAB3 LHFPL1 0 0 0 167 1 1
    TAB3 EDA 0 0 0 332 1 1
    TAB3 ZNF44 0 0 285 284 1 1
    TAB3 TRIM15 0 0 90 154 1 1
    TAB3 BCL2L2 0 0 172 173 1 1
    TAB3 MAP3K7 897 800 723 994 1 1
    TAB3 KPNA3 0 0 112 221 1 1
    TAB3 ERC1 0 0 279 279 1 1
    TAB3 PCYT1B 0 0 0 286 1 1
    TAB3 MSL3 0 0 0 325 1 1
    TAB3 P2RY10 0 0 0 189 1 1
    TAB3 HCCS 0 0 0 213 1 1
    TAB3 PRPS2 0 0 0 181 1 1
    TAB3 TP53 0 0 155 154 1 2
    TAB3 DRP2 0 0 0 153 1 1
    TAB3 MYD88 0 600 507 821 1 1
    TAB3 EFHC2 0 0 0 323 1 1
    TAB3 CFLAR 0 0 261 270 1 1
    TAB3 MAP3K13 0 0 0 207 1 1
    TAB3 DOT1L 0 0 53 198 1 1
    TAB3 FADD 0 0 369 369 1 2
    TAB3 SARM1 0 0 324 462 1 1
    TAB3 UBB 0 650 0 673 1 1
    TAB3 OCRL 0 0 0 246 1 1
    TAB3 TRIM23 0 0 243 288 1 1
    TAB3 TRIM8 0 0 175 276 1 1
    TAB3 DKK2 0 0 46 212 1 1
    TAB3 BMPR2 0 0 70 265 1 1
    TAB3 RLIM 0 0 64 453 1 1
    TAB3 RAB9A 0 0 0 214 1 2
    TAB3 SNX12 0 0 0 323 1 1
    TAB3 CLCN5 0 0 63 278 1 1
    TAB3 STAT3 0 0 165 165 1 2
    TAB3 ENSG00000258973 0 0 0 175 1 1
    TAB3 MOB3A 0 0 0 211 1 1
    TAB3 GUCY2F 0 0 0 215 1 1
    TAB3 CDK14 0 0 150 168 1 1
    TAB3 TRAF3IP2 0 0 172 171 1 1
    TAB3 BMP5 0 0 0 167 1 1
    TAB3 MKKS 0 0 294 584 1 1
    TAB3 ZDHHC15 0 0 0 181 1 1
    TAB3 TRIM6-TRIM34 0 0 82 198 1 1
    TAB3 ARHGAP6 0 0 0 265 1 1
    TAB3 G3BP2 0 0 74 293 1 1
    TAB3 CDX4 0 0 0 150 1 1
    TAB3 TMEM189-UBE2V1 0 0 0 181 1 1
    TAB3 NLRC5 0 0 122 159 1 1
    TAB3 GABRA3 0 0 0 181 1 1
    TAB3 VAMP8 0 0 46 236 1 2
    TAB3 MAGEB6 0 0 0 168 1 1
    TAB3 PSMD10 0 0 0 154 1 1
    TAB3 ADAM7 0 0 142 163 1 1
    TAB3 RPGR 0 0 0 238 1 1
    TAB3 COX7B 0 0 60 196 1 1
    TAB3 HUWE1 0 0 107 407 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0070530 Molecular Function K63-linked polyubiquitin modification-dependent protein binding enables IDA
    GO:0060090 Molecular Function molecular adaptor activity enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0043130 Molecular Function ubiquitin binding enables IEA
    GO:0008270 Molecular Function zinc ion binding enables IDA
    GO:0042742 Biological Process defense response to bacterium involved_in IDA
    GO:0010507 Biological Process negative regulation of autophagy involved_in TAS
    GO:0038061 Biological Process non-canonical NF-kappaB signal transduction involved_in IDA
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IBA
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IDA
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IMP
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0005783 Cellular Component endoplasmic reticulum is_active_in IDA
    GO:0010008 Cellular Component endosome membrane located_in TAS
    GO:0070062 Cellular Component extracellular exosome located_in HDA
    GO:0005886 Cellular Component plasma membrane located_in TAS
    Pathways
    Name DB ID
    IL-1 signaling pathway (WP195) WikiPathways WP195_r120702
    Toll-like receptor signaling pathway (WP75) WikiPathways WP75_r119233
    Interleukin-1 (IL-1) structural pathway (WP2637) WikiPathways WP2637_r117962
    TNF-alpha signaling pathway (WP231) WikiPathways WP231_r124583
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XR_950433 2 miscRNA transcript variant X6 NC_000023 Reference
    NR_174362 1 miscRNA transcript variant 6 NC_000023 Reference
    NR_174361 1 miscRNA transcript variant 5 NC_000023 Reference
    NM_001399872 1 mRNA transcript variant 3 NC_000023 Reference
    NM_001399873 1 mRNA transcript variant 4 NC_000023 Reference
    NM_152787 5 mRNA transcript variant 1 NC_000023 Reference
    XM_047441986 1 mRNA transcript variant X2 NC_000023 Reference
    NM_001399870 1 mRNA transcript variant 2 NC_000023 Reference
    XM_017029400 2 mRNA transcript variant X1 NC_000023 Reference
    XM_047441987 1 mRNA transcript variant X3 NC_000023 Reference
    XM_011545488 3 mRNA transcript variant X4 NC_000023 Reference
    XM_017029402 2 mRNA transcript variant X5 NC_000023 Reference