PLEKHM2

pleckstrin homology and RUN domain containing M2
General Information
Name pleckstrin homology and RUN domain containing M2
Alias
  • pleckstrin homology domain-containing family M member 2
  • PH domain-containing family M member 2
  • SifA (Salmonella-induced filaments A) and kinesin-interacting protein
  • novel RUN and PH domain-containing protein
  • pleckstrin homology domain containing, family M (with RUN domain) member 2
Synonyms KIAA0842 SKIP
Gene_family Pleckstrin homology domain containing
organism Homo sapiens
entrez_id 23207
location 1p36.21
transcript_count 5
exon_count 22
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]
      Stringdb Pleckstrin homology domain-containing family M member 2; May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. May play a role in lysosomes movement and localization at the cell periphery; Pleckstrin homology domain containing
      nextProt Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:28325809, PubMed:22172677, PubMed:25898167, PubMed:24088571). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    PLEKHM2 BioGRID N GeneID BioGRID Reconstituted Complex
    PLEKHM2 BioGRID TOP3B GeneID BioGRID Affinity Capture-RNA
    PLEKHM2 BioGRID ARL8B GeneID BioGRID Co-localization; Proximity Label-MS
    PLEKHM2 BioGRID ARL8A GeneID BioGRID Proximity Label-MS
    PLEKHM2 BioGRID RAB7A GeneID BioGRID Proximity Label-MS
    PLEKHM2 BioGRID IFITM3 GeneID BioGRID Proximity Label-MS
    PLEKHM2 BioGRID IFITM1 GeneID BioGRID Proximity Label-MS
    PLEKHM2 BioGRID RAB9A GeneID BioGRID Proximity Label-MS
    PLEKHM2 BioGRID LAMTOR1 GeneID BioGRID Proximity Label-MS
    PLEKHM2 BioGRID KIF20A GeneID BioGRID Affinity Capture-MS
    PLEKHM2 BioGRID OFD1 GeneID BioGRID Affinity Capture-MS
    PLEKHM2 BioGRID POLR2F GeneID BioGRID Affinity Capture-MS
    PLEKHM2 BioGRID CBR1 GeneID BioGRID Affinity Capture-MS
    PLEKHM2 None SLC39A1 GeneID HPRD None
    PLEKHM2 None KLC1 GeneID HPRD None
    PLEKHM2 Protein KIF5B GeneID BIND SKIP interacts with kinesin HC.
    PLEKHM2 Protein sifA GeneID BIND SifA interacts with SKIP. This interaction was modeled on a demonstrated interaction between SifA from Salmonella typhimurium (strain HH215, strain PH011 and an unspecified strain) and human SKIP.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    PLEKHM2 TESK1 0 0 0 173 1 1
    PLEKHM2 KLC2 0 0 602 628 1 1
    PLEKHM2 ARHGAP25 0 0 270 285 1 1
    PLEKHM2 VPS41 0 0 288 320 1 1
    PLEKHM2 NT5DC3 0 0 155 173 1 1
    PLEKHM2 RBM20 0 0 181 181 1 1
    PLEKHM2 NDEL1 0 0 0 253 1 1
    PLEKHM2 PPP1R3B 0 0 180 179 1 1
    PLEKHM2 EPG5 0 0 261 290 1 2
    PLEKHM2 CHMP4B 0 0 0 153 1 2
    PLEKHM2 PPP2R1A 0 0 0 151 1 1
    PLEKHM2 DNAJC7 0 0 261 261 1 1
    PLEKHM2 ANAPC2 0 0 0 155 1 1
    PLEKHM2 ABCC6 0 0 148 154 1 1
    PLEKHM2 RAB7A 0 0 456 529 1 2
    PLEKHM2 COA8 0 0 390 390 1 1
    PLEKHM2 PNPLA6 0 0 0 170 1 1
    PLEKHM2 CLSTN1 0 0 283 309 1 1
    PLEKHM2 RGPD6 0 0 0 153 1 1
    PLEKHM2 VPS11 0 0 270 315 1 2
    PLEKHM2 NBR1 0 0 69 177 1 2
    PLEKHM2 RGPD1 0 0 0 153 1 1
    PLEKHM2 PPIAL4B 0 0 0 162 1 1
    PLEKHM2 SYNE2 0 0 181 181 1 1
    PLEKHM2 C17orf59 0 0 338 480 1 1
    PLEKHM2 FKRP 0 0 170 169 1 1
    PLEKHM2 PIKFYVE 0 0 0 151 1 1
    PLEKHM2 RILPL1 0 0 114 249 1 1
    PLEKHM2 TTC1 0 0 325 325 1 1
    PLEKHM2 KIF5B 0 0 769 771 1 1
    PLEKHM2 EEA1 0 0 247 246 1 1
    PLEKHM2 DENND5A 0 0 293 327 1 1
    PLEKHM2 KIF24 0 0 218 236 1 1
    PLEKHM2 RAB7B 0 0 425 491 1 1
    PLEKHM2 CLCN7 0 0 0 167 1 1
    PLEKHM2 PTPRQ 0 0 0 213 1 1
    PLEKHM2 WASF1 0 0 142 401 1 1
    PLEKHM2 STX17 0 0 134 177 1 2
    PLEKHM2 KLC1 213 0 469 565 1 1
    PLEKHM2 PLEKHM1 0 0 468 252 1 2
    PLEKHM2 POLA2 0 0 140 388 1 1
    PLEKHM2 SIDT2 0 0 294 294 1 1
    PLEKHM2 KIF2A 0 0 107 169 1 1
    PLEKHM2 C10orf32 0 0 294 294 1 1
    PLEKHM2 NDE1 0 0 0 253 1 1
    PLEKHM2 INTS1 0 0 302 357 1 1
    PLEKHM2 PPIA 0 0 0 162 1 1
    PLEKHM2 CDKN2A 0 0 157 156 1 2
    PLEKHM2 PRCC 0 0 195 195 1 1
    PLEKHM2 KIFAP3 0 0 180 179 1 1
    PLEKHM2 PPIAL4D 0 0 0 162 1 1
    PLEKHM2 RGPD8 0 0 0 153 1 1
    PLEKHM2 TOP2B 0 0 0 181 1 1
    PLEKHM2 ARL14EP 0 0 156 155 1 1
    PLEKHM2 SCAMP3 0 0 232 231 1 1
    PLEKHM2 DNAJC13 0 0 70 155 1 1
    PLEKHM2 RUFY2 0 0 362 362 1 1
    PLEKHM2 RRAGD 0 0 157 156 1 1
    PLEKHM2 HNRNPAB 0 0 205 205 1 1
    PLEKHM2 PRKAG2 0 0 180 179 1 1
    PLEKHM2 KIAA0368 0 0 84 334 1 1
    PLEKHM2 PTPRA 0 0 0 162 1 1
    PLEKHM2 TMEM55B 0 0 281 307 1 1
    PLEKHM2 ACBD3 0 0 194 194 1 1
    PLEKHM2 CTSB 0 0 163 163 1 2
    PLEKHM2 MAPK8IP3 0 0 54 171 1 1
    PLEKHM2 ENSG00000100926 0 0 0 196 1 1
    PLEKHM2 OSBP 0 0 173 173 1 1
    PLEKHM2 RGPD4 0 0 0 153 1 1
    PLEKHM2 RGPD3 0 0 0 153 1 1
    PLEKHM2 ULK1 0 0 95 151 1 2
    PLEKHM2 MAP1LC3B 0 0 150 162 1 2
    PLEKHM2 PSD3 0 0 245 261 1 1
    PLEKHM2 RANBP1 0 0 0 153 1 1
    PLEKHM2 SMIM14 0 0 161 161 1 1
    PLEKHM2 CLTB 0 0 0 193 1 1
    PLEKHM2 M6PR 0 0 212 212 1 1
    PLEKHM2 CTSD 0 0 234 271 1 2
    PLEKHM2 SCAF1 0 0 0 172 1 1
    PLEKHM2 TRIM23 0 0 0 154 1 1
    PLEKHM2 SCAMP2 0 0 160 159 1 1
    PLEKHM2 MCOLN1 0 0 126 157 1 1
    PLEKHM2 RAB9A 270 800 67 868 1 2
    PLEKHM2 MREG 0 0 151 150 1 1
    PLEKHM2 ARPC2 0 0 157 593 1 1
    PLEKHM2 LMNA 0 0 128 168 1 1
    PLEKHM2 KLC4 0 0 261 261 1 1
    PLEKHM2 CREBL2 0 0 0 160 1 1
    PLEKHM2 KIF5C 0 0 158 167 1 1
    PLEKHM2 FLNB 0 0 134 394 1 1
    PLEKHM2 NR1H2 0 0 0 156 1 1
    PLEKHM2 LAMP1 0 0 267 288 1 2
    PLEKHM2 HOMER2 0 0 170 169 1 1
    PLEKHM2 POLR2F 246 0 0 245 1 1
    PLEKHM2 ZNF865 0 0 0 153 1 1
    PLEKHM2 ATCAY 0 0 391 404 1 1
    PLEKHM2 PPIF 0 0 0 162 1 1
    PLEKHM2 TOP2A 0 0 0 181 1 1
    PLEKHM2 FLNA 0 0 0 238 1 1
    PLEKHM2 VPS39 0 0 514 621 1 1
    PLEKHM2 SPTBN2 0 0 172 171 1 1
    PLEKHM2 DVL1 0 0 0 185 1 1
    PLEKHM2 ARL8B 0 0 683 689 1 1
    PLEKHM2 RGPD5 0 0 0 153 1 1
    PLEKHM2 ACOT11 0 0 241 259 1 1
    PLEKHM2 KIF2C 0 0 74 187 1 1
    PLEKHM2 MYPN 0 0 195 195 1 1
    PLEKHM2 ARL5B 0 0 628 636 1 1
    PLEKHM2 PPP2R3C 0 0 261 261 1 1
    PLEKHM2 KIF1A 0 0 138 158 1 1
    PLEKHM2 MAPK8IP1 0 0 90 161 1 1
    PLEKHM2 FYCO1 0 0 458 457 1 2
    PLEKHM2 FLNC 0 0 0 209 1 1
    PLEKHM2 DYNC1LI1 0 0 0 241 1 1
    PLEKHM2 INPPL1 0 0 0 153 1 1
    PLEKHM2 RANBP2 0 0 0 266 1 1
    PLEKHM2 OSBPL1A 0 0 181 218 1 1
    PLEKHM2 CADPS2 0 0 73 226 1 1
    PLEKHM2 DYNC1LI2 0 0 263 618 1 1
    PLEKHM2 PLEK 0 0 500 499 1 1
    PLEKHM2 PDS5B 0 0 163 163 1 1
    PLEKHM2 SEC61A1 0 0 120 159 1 1
    PLEKHM2 PTPRU 0 0 0 161 1 1
    PLEKHM2 ARL8A 0 0 451 494 1 1
    PLEKHM2 ERBB2IP 0 0 51 229 1 1
    PLEKHM2 TGFBRAP1 0 0 261 423 1 1
    PLEKHM2 KLC3 0 0 556 556 1 1
    PLEKHM2 PPIAL4H 0 0 0 162 1 1
    PLEKHM2 BAG3 0 0 193 216 1 2
    PLEKHM2 RAB5A 0 0 260 276 1 2
    PLEKHM2 MYBPC3 0 0 164 163 1 1
    PLEKHM2 RGPD2 0 0 0 153 1 1
    PLEKHM2 SBF1 0 0 0 193 1 1
    PLEKHM2 KIF5A 0 0 150 159 1 1
    PLEKHM2 SPAG9 0 0 181 211 1 1
    PLEKHM2 PRPF40B 0 0 0 158 1 1
    PLEKHM2 STK11IP 0 0 324 349 1 1
    PLEKHM2 PAQR8 0 0 260 260 1 1
    PLEKHM2 SQSTM1 0 0 125 230 1 2
    PLEKHM2 PPIAL4C 0 0 0 162 1 1
    PLEKHM2 RAB24 0 0 125 164 1 2
    PLEKHM2 DENND4B 0 0 165 216 1 1
    PLEKHM2 MOSPD3 0 0 150 168 1 1
    PLEKHM2 RAB35 0 0 244 288 1 1
    PLEKHM2 RAB1A 0 0 453 453 1 2
    PLEKHM2 VPS16 0 0 184 277 1 1
    PLEKHM2 PRPF40A 0 0 0 158 1 1
    PLEKHM2 LAMP2 0 0 263 263 1 2
    PLEKHM2 MIB2 0 0 0 189 1 1
    PLEKHM2 RILP 0 0 400 458 1 1
    PLEKHM2 CSNK1A1 0 0 219 439 1 1
    PLEKHM2 WAPAL 0 0 182 202 1 1
    PLEKHM2 SNX3 0 0 217 217 1 1
    PLEKHM2 REXO1 0 0 0 155 1 1
    PLEKHM2 MEF2BNB 0 0 337 549 1 1
    PLEKHM2 KIF1B 0 0 244 262 1 1
    PLEKHM2 PHF12 0 0 0 174 1 1
    PLEKHM2 ZFYVE27 0 0 261 287 1 1
    PLEKHM2 LOH12CR1 0 0 324 603 1 1
    PLEKHM2 GOLGB1 0 0 203 220 1 1
    PLEKHM2 CBR1 246 0 0 263 1 1
    PLEKHM2 TBC1D15 0 0 246 263 1 1
    PLEKHM2 PPIAL4G 0 0 0 162 1 1
    PLEKHM2 CSNK1A1L 0 0 0 311 1 1
    PLEKHM2 RUSC2 0 0 391 439 1 1
    PLEKHM2 SORCS2 0 0 75 232 1 1
    PLEKHM2 GCC2 0 0 74 183 1 1
    PLEKHM2 RAB31 0 0 155 173 1 1
    PLEKHM2 RAB6A 0 0 209 226 1 1
    PLEKHM2 NISCH 0 0 137 163 1 1
    PLEKHM2 RAB36 0 0 181 198 1 1
    PLEKHM2 CD79B 0 0 0 155 1 1
    PLEKHM2 VPS33A 0 0 386 386 1 1
    PLEKHM2 VPS18 0 0 244 380 1 1
    PLEKHM2 DYNC2H1 0 0 181 504 1 1
    PLEKHM2 PPIAL4F 0 0 0 162 1 1
    PLEKHM2 KIF20A 270 0 47 274 1 1
    PLEKHM2 DCTN1 0 0 203 248 1 1
    PLEKHM2 RAB9B 0 800 0 822 1 1
    PLEKHM2 WAC 0 0 0 158 1 1
    PLEKHM2 ENSG00000279782 0 0 0 162 1 1
    PLEKHM2 ARPC1A 0 0 0 250 1 1
    PLEKHM2 PIP5K1C 0 0 0 150 1 1
    PLEKHM2 ARPC1B 0 0 176 605 1 1
    PLEKHM2 KIF16B 0 0 167 188 1 1
    PLEKHM2 TPRN 0 0 269 312 1 1
    PLEKHM2 VPS8 0 0 211 400 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0019894 Molecular Function kinesin binding enables IBA
    GO:0019894 Molecular Function kinesin binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0007030 Biological Process Golgi organization involved_in IBA
    GO:0007030 Biological Process Golgi organization involved_in IMP
    GO:0032418 Biological Process lysosome localization involved_in IBA
    GO:0032418 Biological Process lysosome localization involved_in IDA
    GO:0032418 Biological Process lysosome localization involved_in IMP
    GO:0042267 Biological Process natural killer cell mediated cytotoxicity involved_in IMP
    GO:0032880 Biological Process regulation of protein localization involved_in IBA
    GO:0032880 Biological Process regulation of protein localization involved_in IMP
    GO:0010008 Cellular Component endosome membrane is_active_in IBA
    GO:0010008 Cellular Component endosome membrane located_in IDA
    GO:0005765 Cellular Component lysosomal membrane located_in IDA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XM_017000757 1 mRNA transcript variant X1 NC_000001 Reference
    XM_017000758 1 mRNA transcript variant X2 NC_000001 Reference
    NM_015164 4 mRNA transcript variant 1 NC_000001 Reference
    NM_001410755 1 mRNA transcript variant 2 NC_000001 Reference
    XM_005245791 5 mRNA transcript variant X3 NC_000001 Reference