SMCR8

SMCR8-C9orf72 complex subunit
General Information
Name SMCR8-C9orf72 complex subunit
Alias
  • guanine nucleotide exchange protein SMCR8
  • Smith-Magenis syndrome chromosome region, candidate 8
  • smith-Magenis syndrome chromosomal region candidate gene 8 protein
Synonyms FLJ34716 DENND8A
Gene_family SWC tripartite complex|DENN domain containing
organism Homo sapiens
entrez_id 140775
location 17p11.2
transcript_count 1
exon_count 2
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Enables GTPase activator activity; protein kinase binding activity; and protein kinase inhibitor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in negative regulation of gene expression; regulation of TOR signaling; and regulation of macroautophagy. Located in Atg1/ULK1 kinase complex; chromatin; and nucleoplasm. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Mar 2025]
      Stringdb Guanine nucleotide exchange protein SMCR8; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activ [...]
      nextProt Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    SMCR8 BioGRID XPO7 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID E GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID KCNA3 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID FAM90A1 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID RAB25 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RET GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID FGFR4 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID FGFR1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID EPHA8 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID ALK GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID ARL10 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RAB7A GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RHOJ GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID RHOQ GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID RND2 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID RHOH GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID RHOG GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID RND3 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID RHOA GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID FEM1B GeneID BioGRID Co-crystal Structure; Protein-peptide
    SMCR8 BioGRID RB1CC1 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID TMPRSS4 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID CLEC4E GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID IFITM3 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID IFITM1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID FURIN GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID DUSP16 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID NAA40 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID ZNRD2 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID MAGEA9 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID IMPDH2 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID IMPDH1 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID FTL GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID CRYAB GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID CAMK2A GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID EEF1AKMT2 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID PIPSL GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID C9orf72 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    SMCR8 BioGRID KRTCAP3 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID RAB11A GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID STX7 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID AKAP1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID REEP5 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID ZYX GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID ZFPL1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID VCL GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID TMPO GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID SEC62 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID STX4 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID STIM1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID SSR1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RPN2 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RAB5C GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RAB5A GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RAB4A GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RAB3B GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID PXMP2 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID PEX14 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID MARCKS GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID LMAN1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID LAMP2 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID GOLGA1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID GJA1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID EMD GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID CXADR GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID CAV1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID GJD3 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID ACBD5 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID LNPK GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID HSD3B7 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID DERL1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID GORASP1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID ELOVL5 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID LRRC59 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID LAMTOR1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID HSD17B11 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID B3GAT1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID LAMP3 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID TMT1A GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID PHB2 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RAB35 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID CKAP4 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID SEC61B GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID STX6 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID BCAP31 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID NUP155 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RAB9A GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID EBAG9 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID AIFM1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID DNAJC25 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID DNAJC1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID DNAJC16 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID SEC63 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID PRKACA GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID NR3C1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID SLC25A46 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RHOT2 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID MAVS GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID EXD2 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID RMDN3 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID OCIAD1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID MARCHF5 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID FIS1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID MTCH2 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID MTCH1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID FKBP8 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID MFN2 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID ST7 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID PTPN1 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID OTULINL GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID WDR41 GeneID BioGRID Co-purification
    SMCR8 BioGRID ATG13 GeneID BioGRID Two-hybrid
    SMCR8 BioGRID ULK1 GeneID BioGRID Two-hybrid
    SMCR8 BioGRID COX14 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID TOMM22 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID PTRH2 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID VIRMA GeneID BioGRID Affinity Capture-RNA
    SMCR8 BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID TOMM20 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID MGST3 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID CANX GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID TBK1 GeneID BioGRID Biochemical Activity
    SMCR8 BioGRID FANCA GeneID BioGRID Affinity Capture-Luminescence
    SMCR8 BioGRID TMEM17 GeneID BioGRID Proximity Label-MS
    SMCR8 BioGRID CDC16 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID NTRK1 GeneID BioGRID Affinity Capture-MS
    SMCR8 BioGRID MMS19 GeneID BioGRID Affinity Capture-MS
    StringDB
    A B experiments database textmining combined score hadb nhadb
    SMCR8 KLHL32 0 0 112 175 1 1
    SMCR8 DENND1B 0 0 261 277 1 1
    SMCR8 RAB10 0 0 127 309 1 1
    SMCR8 FAM132B 0 0 145 276 1 1
    SMCR8 MED9 0 0 210 218 1 1
    SMCR8 WDR77 0 0 113 186 1 1
    SMCR8 MOB3B 0 0 71 653 1 1
    SMCR8 IGSF11 0 0 190 272 1 1
    SMCR8 RMDN3 117 0 224 299 1 1
    SMCR8 RAB3IL1 0 0 160 306 1 1
    SMCR8 ACSL6 0 0 113 219 1 1
    SMCR8 RAB33A 0 0 279 284 1 1
    SMCR8 HTT 0 0 123 162 1 1
    SMCR8 SPG11 0 0 112 275 1 1
    SMCR8 LAMP1 0 0 268 305 1 2
    SMCR8 PRKDC 0 0 0 176 1 2
    SMCR8 ALAD 0 0 113 176 1 1
    SMCR8 ENSG00000273637 0 0 0 646 1 1
    SMCR8 CD300C 0 0 181 181 1 1
    SMCR8 ATG2A 0 0 48 239 1 2
    SMCR8 RASGRP3 0 360 0 363 1 1
    SMCR8 GPR85 0 0 150 281 1 1
    SMCR8 COQ10B 0 0 241 442 1 1
    SMCR8 MOB3A 0 0 0 543 1 1
    SMCR8 NPR2 0 0 112 236 1 1
    SMCR8 RAB8A 0 800 595 939 1 2
    SMCR8 ENPP3 0 0 113 168 1 1
    SMCR8 RAB3IP 0 0 108 247 1 1
    SMCR8 AQP11 0 0 141 194 1 1
    SMCR8 IMPDH2 738 0 0 738 1 1
    SMCR8 COL6A5 0 0 167 167 1 1
    SMCR8 CLYBL 0 0 62 162 1 1
    SMCR8 NPRL2 0 0 164 163 1 1
    SMCR8 SGSM3 0 0 150 222 1 1
    SMCR8 GBA 0 0 95 151 1 1
    SMCR8 CCDC74A 0 0 418 454 1 1
    SMCR8 PACS1 0 0 0 157 1 1
    SMCR8 ZBTB10 0 0 113 264 1 1
    SMCR8 ANKRD12 0 0 206 206 1 1
    SMCR8 MYO15A 0 0 134 154 1 1
    SMCR8 WIPI2 0 0 265 281 1 2
    SMCR8 HCN3 0 0 165 234 1 1
    SMCR8 FNIP2 0 0 458 551 1 1
    SMCR8 ZFYVE26 0 0 0 167 1 1
    SMCR8 ENSG00000261832 0 0 108 158 1 1
    SMCR8 RPAP1 0 0 0 167 1 1
    SMCR8 TANK 0 800 439 883 1 1
    SMCR8 RAB3B 0 0 146 251 1 1
    SMCR8 PURA 0 0 129 156 1 1
    SMCR8 PARK2 0 0 134 152 1 1
    SMCR8 SLC25A21 0 0 206 342 1 1
    SMCR8 SLC25A12 0 0 125 217 1 1
    SMCR8 ARNT2 0 0 108 163 1 1
    SMCR8 RAB11FIP5 0 0 143 240 1 1
    SMCR8 RAB3GAP1 0 0 171 260 1 1
    SMCR8 BOLA2 0 0 0 176 1 1
    SMCR8 RAB3C 0 0 195 252 1 1
    SMCR8 ENSG00000248751 0 0 0 206 1 1
    SMCR8 RAB1B 0 0 0 240 1 2
    SMCR8 MSANTD3-TMEFF1 0 0 0 250 1 1
    SMCR8 SEC14L2 0 0 167 254 1 1
    SMCR8 VWCE 0 0 218 218 1 1
    SMCR8 WDR45 0 0 90 181 1 2
    SMCR8 RB1CC1 249 720 651 921 1 2
    SMCR8 RAB39A 0 0 213 612 1 1
    SMCR8 INMT 0 0 150 266 1 1
    SMCR8 DRG2 0 0 234 235 1 1
    SMCR8 TMEM55A 0 0 0 435 1 1
    SMCR8 RAB7A 0 0 492 545 1 2
    SMCR8 SYNGR2 0 0 176 248 1 1
    SMCR8 C9orf72 973 800 989 999 1 2
    SMCR8 SOAT1 0 0 97 153 1 1
    SMCR8 ARHGEF12 0 0 94 155 1 1
    SMCR8 RBM45 0 0 0 186 1 1
    SMCR8 NRBP2 0 0 122 202 1 1
    SMCR8 CA3 0 0 95 151 1 1
    SMCR8 CACFD1 0 0 338 451 1 1
    SMCR8 ZKSCAN3 0 0 155 154 1 2
    SMCR8 FLNC 0 0 161 180 1 1
    SMCR8 FARP1 0 0 155 285 1 1
    SMCR8 CDC16 151 0 92 196 1 1
    SMCR8 NDUFB6 0 0 46 556 1 1
    SMCR8 CCDC126 0 0 294 294 1 1
    SMCR8 PINK1 0 0 260 276 1 2
    SMCR8 UBQLN1 0 0 61 203 1 2
    SMCR8 ST7 226 0 0 225 1 1
    SMCR8 FIG4 0 0 134 207 1 1
    SMCR8 KIF2B 0 0 171 239 1 1
    SMCR8 ARHGEF6 0 0 118 187 1 1
    SMCR8 KNDC1 0 720 0 720 1 1
    SMCR8 PIKFYVE 0 0 54 215 1 1
    SMCR8 GTPBP2 0 0 113 168 1 1
    SMCR8 RAP1A 0 360 0 374 1 1
    SMCR8 SMG1 0 0 0 176 1 1
    SMCR8 AVL9 0 0 391 390 1 1
    SMCR8 GAPDH 0 0 124 178 1 2
    SMCR8 ATG14 0 0 161 161 1 2
    SMCR8 SPATA31E1 0 0 207 207 1 1
    SMCR8 LPHN3 0 0 124 191 1 1
    SMCR8 EIF2B2 0 0 143 233 1 1
    SMCR8 RBMXL1 0 0 0 181 1 1
    SMCR8 LINGO2 0 0 53 623 1 1
    SMCR8 RAB33B 0 0 181 188 1 2
    SMCR8 REEP6 0 0 205 230 1 1
    SMCR8 ALS2 0 0 287 330 1 1
    SMCR8 WDTC1 0 0 0 375 1 1
    SMCR8 SBF2 0 0 46 206 1 1
    SMCR8 CITED4 0 0 162 250 1 1
    SMCR8 PACS2 0 0 0 157 1 1
    SMCR8 RAB7B 0 0 310 330 1 1
    SMCR8 DCAF6 0 0 0 375 1 1
    SMCR8 ITGBL1 0 0 124 363 1 1
    SMCR8 ZGRF1 0 0 293 308 1 1
    SMCR8 BOLA2-SMG1P6 0 0 0 176 1 1
    SMCR8 DOCK1 0 720 0 729 1 1
    SMCR8 CLN3 0 0 107 157 1 2
    SMCR8 TARSL2 0 0 162 245 1 1
    SMCR8 TBK1 270 800 458 936 1 2
    SMCR8 KIAA1429 270 0 0 270 1 1
    SMCR8 ATG2B 0 0 47 324 1 2
    SMCR8 RAB5A 0 0 294 338 1 2
    SMCR8 RAB11A 0 0 358 372 1 1
    SMCR8 TOMM20 118 0 60 244 1 1
    SMCR8 SYNPR 0 0 280 281 1 1
    SMCR8 SLC25A5 0 0 103 164 1 1
    SMCR8 CYP2F1 0 0 159 288 1 1
    SMCR8 SHMT1 0 0 161 161 1 1
    SMCR8 KCNJ9 0 0 139 287 1 1
    SMCR8 WBSCR22 0 0 181 263 1 1
    SMCR8 TAF2 0 0 0 189 1 1
    SMCR8 PIRT 0 0 208 208 1 1
    SMCR8 PIK3C3 0 0 96 181 1 2
    SMCR8 CHMP2B 0 0 421 433 1 2
    SMCR8 RAB12 0 0 337 418 1 2
    SMCR8 CEP170 0 0 174 211 1 1
    SMCR8 WDR24 0 0 0 183 1 1
    SMCR8 ATXN2 0 0 391 418 1 1
    SMCR8 MTOR 0 0 180 625 1 2
    SMCR8 RAB25 0 0 193 210 1 2
    SMCR8 PQLC2 0 0 244 243 1 1
    SMCR8 KIF1C 0 0 54 161 1 1
    SMCR8 TARDBP 0 0 400 401 1 1
    SMCR8 SYN1 0 0 74 240 1 1
    SMCR8 WDR41 847 800 988 999 1 2
    SMCR8 DTL 0 0 113 289 1 1
    SMCR8 PDE3B 0 720 0 720 1 1
    SMCR8 ATG9A 0 0 139 414 1 2
    SMCR8 RAB24 0 0 261 276 1 2
    SMCR8 RAB42 0 0 0 201 1 1
    SMCR8 TOMM22 160 0 0 159 1 1
    SMCR8 CRYAB 288 0 0 288 1 1
    SMCR8 RAB1A 0 0 509 553 1 2
    SMCR8 RAB35 0 0 248 262 1 1
    SMCR8 TMEM175 0 0 140 192 1 1
    SMCR8 NDRG3 0 0 163 215 1 1
    SMCR8 PI4KA 0 0 45 163 1 1
    SMCR8 TMEM106B 0 0 173 179 1 1
    SMCR8 SH3TC2 0 0 49 151 1 1
    SMCR8 CLEC16A 0 0 0 167 1 2
    SMCR8 RAB29 0 0 324 374 1 1
    SMCR8 HSPB8 0 0 103 165 1 2
    SMCR8 ATG101 0 0 464 463 1 2
    SMCR8 PDIA2 0 0 143 162 1 1
    SMCR8 SBF1 0 0 53 234 1 1
    SMCR8 TFEB 0 0 426 477 1 2
    SMCR8 CFAP57 0 0 320 441 1 1
    SMCR8 TMC4 0 0 241 241 1 1
    SMCR8 SQSTM1 0 0 459 493 1 2
    SMCR8 ATG12 0 0 95 154 1 2
    SMCR8 ATG13 192 720 454 880 1 2
    SMCR8 TMEM56 0 0 282 359 1 1
    SMCR8 ULK2 0 800 104 831 1 2
    SMCR8 LRRK2 0 0 147 223 1 2
    SMCR8 SLC5A2 0 0 72 236 1 1
    SMCR8 RUFY2 0 0 0 167 1 1
    SMCR8 FGD1 0 0 148 249 1 1
    SMCR8 COQ10A 0 0 0 295 1 1
    SMCR8 BAG5 0 0 141 213 1 1
    SMCR8 SNCA 0 0 163 163 1 2
    SMCR8 BECN1 0 0 163 214 1 2
    SMCR8 DGCR2 0 0 193 243 1 1
    SMCR8 TAF1 0 0 0 165 1 1
    SMCR8 DENND3 0 0 375 408 1 2
    SMCR8 CDKL1 0 0 181 181 1 1
    SMCR8 TBKBP1 0 0 454 559 1 1
    SMCR8 RAB3D 0 0 153 241 1 1
    SMCR8 RBMXL2 0 0 262 275 1 1
    SMCR8 LRRC48 0 0 284 298 1 1
    SMCR8 RBMX 0 0 0 181 1 1
    SMCR8 RRAGD 0 0 165 528 1 1
    SMCR8 KIAA1147 0 0 294 294 1 1
    SMCR8 CHCHD10 0 0 140 193 1 1
    SMCR8 RRAGC 0 0 345 758 1 1
    SMCR8 SLC47A2 0 0 141 171 1 1
    SMCR8 SOD1 0 0 233 232 1 1
    SMCR8 TMEM11 0 0 115 205 1 1
    SMCR8 IFNK 0 0 49 432 1 1
    SMCR8 VCP 0 0 254 278 1 2
    SMCR8 ADARB2 0 0 135 189 1 1
    SMCR8 LAMP2 0 0 234 313 1 2
    SMCR8 GRN 0 0 268 380 1 1
    SMCR8 DOCK9 0 0 155 262 1 1
    SMCR8 SLC47A1 0 0 108 153 1 1
    SMCR8 NATD1 0 0 413 412 1 1
    SMCR8 DHRS7B 0 0 325 325 1 1
    SMCR8 RAB39B 0 800 710 971 1 2
    SMCR8 ENSG00000280433 0 0 0 187 1 1
    SMCR8 WDR4 0 0 402 499 1 1
    SMCR8 TBC1D25 0 0 207 224 1 1
    SMCR8 TFE3 0 0 157 291 1 1
    SMCR8 FANCA 270 0 0 270 1 1
    SMCR8 CHMP5 0 0 49 628 1 1
    SMCR8 ULK1 192 800 327 883 1 2
    SMCR8 RAB38 0 0 276 281 1 1
    SMCR8 GABBR2 0 0 91 157 1 1
    SMCR8 LDB3 0 0 107 197 1 1
    SMCR8 TBC1D14 0 0 206 223 1 2
    SMCR8 MRPL44 0 0 230 229 1 1
    SMCR8 IMPDH1 291 0 0 290 1 1
    SMCR8 TRAPPC10 0 0 144 295 1 1
    SMCR8 FNIP1 0 0 459 626 1 1
    SMCR8 RAB6A 0 0 184 183 1 1
    SMCR8 RAB3A 0 0 441 441 1 1
    SMCR8 SNX29 0 0 0 163 1 1
    SMCR8 ATG10 0 0 138 191 1 2
    SMCR8 HNRNPA2B1 0 0 147 207 1 1
    SMCR8 TMEFF1 0 0 60 317 1 1
    SMCR8 AGFG1 0 0 280 338 1 1
    SMCR8 MAP1LC3B 0 0 194 194 1 2
    SMCR8 GRIN1 0 0 103 203 1 1
    SMCR8 ATG5 0 0 167 199 1 2
    SMCR8 CALCOCO2 0 0 243 242 1 2
    SMCR8 CLTC 0 0 81 177 1 1
    SMCR8 MOB3C 0 0 0 420 1 1
    SMCR8 FUS 0 0 273 273 1 1
    SMCR8 ATPAF2 0 0 172 173 1 1
    SMCR8 NT5M 0 0 207 216 1 1
    SMCR8 RAB31 0 0 208 219 1 1
    SMCR8 RAB8B 0 0 123 356 1 2
    SMCR8 RAB13 0 0 163 266 1 2
    SMCR8 IFNB1 0 0 0 189 1 1
    SMCR8 NAGS 0 0 161 254 1 1
    SMCR8 UBQLN2 0 0 371 371 1 2
    SMCR8 OPTN 0 0 496 529 1 2
    SMCR8 FLCN 0 0 642 866 1 1
    SMCR8 TMEM55B 0 0 210 705 1 1
    SMCR8 CLN6 0 0 147 247 1 1
    SMCR8 MADD 0 0 774 794 1 1
    SMCR8 RHOT2 117 0 45 200 1 1
    SMCR8 ELMO1 0 720 0 720 1 1
    SMCR8 ADD3 0 0 122 211 1 1
    SMCR8 ERCC6L 0 0 150 319 1 1
    SMCR8 DOCK8 0 0 90 207 1 1
    SMCR8 TBC1D10A 0 0 181 322 1 1
    SMCR8 VPS8 0 0 0 183 1 1
    SMCR8 CYFIP2 0 0 107 171 1 1
    SMCR8 ARHGEF40 0 0 233 359 1 1
    SMCR8 KIF16B 0 0 0 154 1 1
    SMCR8 MMS19 270 0 142 684 1 1
    SMCR8 KIAA0226 0 0 0 168 1 1
    SMCR8 SSSCA1 179 0 0 179 1 1
    SMCR8 RRAGB 0 0 167 167 1 2
    SMCR8 EIF2B3 0 540 0 540 1 1
    SMCR8 DGCR14 0 0 90 287 1 1
    SMCR8 DLG4 0 0 135 202 1 1
    SMCR8 DCTN1 0 0 163 260 1 1
    SMCR8 ATG7 0 0 193 265 1 2
    SMCR8 DGKI 0 360 0 360 1 1
    SMCR8 TAF1L 0 0 0 165 1 1
    SMCR8 BOLA2B 0 0 0 176 1 1
    SMCR8 FAM45A 0 0 156 155 1 1
    SMCR8 GLP2R 0 0 151 150 1 1
    SMCR8 MON2 0 0 0 155 1 1
    SMCR8 COPS3 0 0 181 181 1 1
    SMCR8 STRADB 0 0 193 266 1 1
    SMCR8 LLGL1 0 0 123 205 1 1
    SMCR8 TBC1D2 0 0 171 189 1 1
    SMCR8 RAB32 0 0 202 207 1 2
    SMCR8 SSX2IP 0 0 150 243 1 1
    SMCR8 SDSL 0 0 215 351 1 1
    SMCR8 CTSD 0 0 134 152 1 2
    SMCR8 RIC1 0 720 0 750 1 1
    SMCR8 RGP1 0 720 0 726 1 1
    SMCR8 NSUN5 0 0 0 203 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005096 Molecular Function GTPase activator activity enables IMP
    GO:0005085 Molecular Function guanyl-nucleotide exchange factor activity contributes_to IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0019901 Molecular Function protein kinase binding enables IPI
    GO:0004860 Molecular Function protein kinase inhibitor activity enables IMP
    GO:0006914 Biological Process autophagy involved_in IEA
    GO:1902902 Biological Process negative regulation of autophagosome assembly involved_in IMP
    GO:0045920 Biological Process negative regulation of exocytosis involved_in NAS
    GO:0010629 Biological Process negative regulation of gene expression involved_in IMP
    GO:0050777 Biological Process negative regulation of immune response involved_in NAS
    GO:0016242 Biological Process negative regulation of macroautophagy involved_in IMP
    GO:0032008 Biological Process positive regulation of TOR signaling involved_in IMP
    GO:1901098 Biological Process positive regulation of autophagosome maturation involved_in IMP
    GO:1903432 Biological Process regulation of TORC1 signaling involved_in IMP
    GO:0010506 Biological Process regulation of autophagy involved_in IMP
    GO:0010506 Biological Process regulation of autophagy involved_in NAS
    GO:1990316 Cellular Component Atg1/ULK1 kinase complex part_of IDA
    GO:0042995 Cellular Component cell projection located_in IEA
    GO:0000785 Cellular Component chromatin located_in IDA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005737 Cellular Component cytoplasm located_in NAS
    GO:0032045 Cellular Component guanyl-nucleotide exchange factor complex part_of IBA
    GO:0032045 Cellular Component guanyl-nucleotide exchange factor complex part_of IDA
    GO:0032045 Cellular Component guanyl-nucleotide exchange factor complex part_of IPI
    GO:0005654 Cellular Component nucleoplasm located_in IDA
    GO:0098794 Cellular Component postsynapse located_in ISS
    GO:0098793 Cellular Component presynapse located_in ISS
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_144775 3 mRNA None NC_000017 Reference