SNX18

sorting nexin 18
General Information
Name sorting nexin 18
Alias
  • sorting nexin-18
  • SH3 and PX domain-containing protein 3B
  • sorting nexin associated golgi protein 1
  • sorting nexin-associated Golgi protein 1
Synonyms SH3PX2 SH3PXD3B SNAG1
Gene_family Sorting nexins|PX-BAR domain containing
organism Homo sapiens
entrez_id 112574
location 5q11.2
transcript_count 7
exon_count 6
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
      Stringdb Sorting nexin-18; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 loc [...]
      nextProt Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis (PubMed:20427313, PubMed:18411244, PubMed:21048941, PubMed:22718350). Required for efficient progress through mitosis and cytokinesis (PubMed:22718350). Required for normal formation of the cleavage furrow at the end of mitosis (PubMed:22718350). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis (PubMed:20427313). Plays a role in macropinocytosis (PubMed:21048941). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation (PubMed:18411244). Stimulates the GTPase activity of DNM2 (PubMed:20427313). Promotes DNM2 location at the plasma membrane (PubMed:20427313). Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A (PubMed:29437695).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    SNX18 BioGRID XPO7 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID ABCA8 GeneID BioGRID Cross-Linking-MS (XL-MS)
    SNX18 BioGRID RPA1 GeneID BioGRID Proximity Label-MS
    SNX18 BioGRID RPA3 GeneID BioGRID Proximity Label-MS
    SNX18 BioGRID STAU1 GeneID BioGRID Proximity Label-MS
    SNX18 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID CCNF GeneID BioGRID Proximity Label-MS
    SNX18 BioGRID AURKA GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID PRKN GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID SOX2 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID SIRT6 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID BRD4 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID BRD2 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID RELL1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID PRECSIT GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID SNX33 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID ZNF784 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID C5orf24 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID ZNF764 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID FBXO11 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID ZBTB44 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID DISC1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID SLU7 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID RAMP1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID RBX1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID ADAMTS1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID GRAP2 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID CDC16 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID ZNF74 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID VDR GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID SKP1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID SDC2 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID PIGF GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID LAG3 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID KRT2 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID GRB2 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID EFNB1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID CD44 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID CD6 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID BMP2 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID ASIP GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID RIN3 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID MEX3B GeneID BioGRID Proximity Label-MS
    SNX18 BioGRID PDPK1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID MAP1LC3B GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    SNX18 BioGRID ATG16L1 GeneID BioGRID Affinity Capture-Western; Co-fractionation
    SNX18 BioGRID ATG14 GeneID BioGRID Co-fractionation
    SNX18 BioGRID GABARAP GeneID BioGRID Reconstituted Complex
    SNX18 BioGRID ZBTB42 GeneID BioGRID Two-hybrid
    SNX18 BioGRID HSPB2-C11orf52 GeneID BioGRID Two-hybrid
    SNX18 BioGRID CYSRT1 GeneID BioGRID Two-hybrid
    SNX18 BioGRID KRTAP6-3 GeneID BioGRID Two-hybrid
    SNX18 BioGRID MSS51 GeneID BioGRID Two-hybrid
    SNX18 BioGRID KRTAP1-1 GeneID BioGRID Two-hybrid
    SNX18 BioGRID CPSF7 GeneID BioGRID Two-hybrid
    SNX18 BioGRID DPPA4 GeneID BioGRID Two-hybrid
    SNX18 BioGRID PTPN21 GeneID BioGRID Two-hybrid
    SNX18 BioGRID HSF2BP GeneID BioGRID Two-hybrid
    SNX18 BioGRID KHDRBS3 GeneID BioGRID Two-hybrid
    SNX18 BioGRID ABI2 GeneID BioGRID Two-hybrid
    SNX18 BioGRID MDFI GeneID BioGRID Two-hybrid
    SNX18 BioGRID HSPB2 GeneID BioGRID Two-hybrid
    SNX18 BioGRID GOLGA2 GeneID BioGRID Two-hybrid
    SNX18 BioGRID DYRK1A GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID BICD1 GeneID BioGRID Proximity Label-MS
    SNX18 BioGRID H2AC4 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID ARIH1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID ORF21 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID RNGTT GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID DNM2 GeneID BioGRID Affinity Capture-Western
    SNX18 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID EWSR1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID UBR2 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID Pi4k2a GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID ANKRD28 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    SNX18 BioGRID CBL GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID CUL1 GeneID BioGRID Affinity Capture-MS
    SNX18 BioGRID FASLG GeneID BioGRID Affinity Capture-Western
    SNX18 BioGRID ITCH GeneID BioGRID Affinity Capture-Western
    SNX18 Protein SOS2 GeneID HPRD None
    SNX18 Protein SOS1 GeneID HPRD None
    StringDB
    A B experiments database textmining combined score hadb nhadb
    SNX18 PARD6B 0 0 138 160 1 1
    SNX18 SNX5 0 0 506 661 1 1
    SNX18 PACSIN2 0 0 364 415 1 1
    SNX18 ULK1 0 0 163 163 1 2
    SNX18 RIPK4 0 0 0 221 1 1
    SNX18 DHRS4L2 0 0 156 202 1 1
    SNX18 HSD17B3 0 0 103 169 1 1
    SNX18 TBC1D14 0 0 517 648 1 2
    SNX18 WDFY4 0 0 0 171 1 1
    SNX18 SNAP91 0 0 155 196 1 1
    SNX18 BTBD1 0 0 0 153 1 1
    SNX18 MAP1LC3B 270 0 96 373 1 2
    SNX18 FOXB1 0 0 150 203 1 1
    SNX18 CGN 0 0 285 320 1 1
    SNX18 SNX13 0 0 0 286 1 1
    SNX18 ALPK3 0 0 181 181 1 1
    SNX18 ADAM17 270 0 103 317 1 1
    SNX18 ATG10 0 0 160 161 1 2
    SNX18 PACSIN3 0 0 393 237 1 1
    SNX18 HS1BP3 0 0 247 510 1 2
    SNX18 VAMP3 0 0 232 231 1 1
    SNX18 BARX1 0 0 117 182 1 1
    SNX18 ADAM19 0 0 195 195 1 1
    SNX18 CTXN3 0 0 195 195 1 1
    SNX18 DYRK1A 270 0 0 270 1 1
    SNX18 GIT1 0 0 112 173 1 1
    SNX18 NECAP1 0 0 282 412 1 1
    SNX18 AP4E1 0 0 58 167 1 1
    SNX18 YAP1 0 0 0 164 1 1
    SNX18 SNX6 0 0 520 670 1 1
    SNX18 ATG5 0 0 181 181 1 2
    SNX18 PTPRA 0 0 97 172 1 1
    SNX18 OPTN 0 0 181 203 1 2
    SNX18 SH3D19 0 0 282 484 1 1
    SNX18 TRAPPC5 0 0 64 204 1 1
    SNX18 ZFP36L1 0 0 94 427 1 1
    SNX18 WLS 0 0 0 210 1 1
    SNX18 LYN 0 0 73 174 1 1
    SNX18 AGAP1 0 0 60 156 1 1
    SNX18 INPP4A 0 0 91 318 1 1
    SNX18 FKTN 0 0 113 178 1 1
    SNX18 DOCK4 0 0 0 259 1 1
    SNX18 SH3BP1 0 0 325 325 1 1
    SNX18 MARK2 0 0 135 408 1 1
    SNX18 CD164 0 0 154 224 1 1
    SNX18 SH3GL1 0 0 277 292 1 1
    SNX18 WIPI1 0 0 207 207 1 2
    SNX18 DNM1L 0 0 66 272 1 2
    SNX18 PI4KB 0 0 142 158 1 1
    SNX18 NOSTRIN 0 0 321 495 1 1
    SNX18 SEC22A 0 0 74 284 1 1
    SNX18 GABARAP 270 0 195 498 1 2
    SNX18 VPS26B 0 0 229 451 1 1
    SNX18 HECW2 0 0 0 164 1 1
    SNX18 CYFIP2 0 0 95 159 1 1
    SNX18 SYTL2 0 0 285 284 1 1
    SNX18 NCK1 0 0 167 406 1 1
    SNX18 DBH 0 0 0 187 1 1
    SNX18 SNX17 0 0 74 332 1 1
    SNX18 ZFPL1 0 0 0 195 1 1
    SNX18 EXOC4 0 0 150 168 1 1
    SNX18 TJP1 0 0 153 162 1 1
    SNX18 PAPLN 0 0 0 159 1 1
    SNX18 ATG7 0 0 126 218 1 2
    SNX18 CDH11 0 0 60 188 1 1
    SNX18 SNX30 0 0 390 254 1 1
    SNX18 RPL21 0 0 45 161 1 1
    SNX18 CLTB 0 0 150 242 1 1
    SNX18 HIVEP2 0 0 0 260 1 1
    SNX18 RAD23B 0 0 74 326 1 1
    SNX18 PLEKHA7 0 0 0 164 1 1
    SNX18 ENSG00000267261 0 0 0 164 1 1
    SNX18 ZSCAN12 0 0 82 153 1 1
    SNX18 AMPH 0 0 517 613 1 1
    SNX18 COPG2 0 0 0 231 1 1
    SNX18 MRC1 0 0 0 168 1 1
    SNX18 HIP1R 0 0 182 254 1 1
    SNX18 INSRR 0 0 0 245 1 1
    SNX18 HCK 0 0 107 218 1 1
    SNX18 ATG16L1 270 0 502 621 1 2
    SNX18 INPP4B 0 0 0 200 1 1
    SNX18 PIK3CD 0 600 0 618 1 1
    SNX18 MAP3K10 0 0 113 519 1 1
    SNX18 FCHSD1 0 0 590 671 1 1
    SNX18 CT47A5 0 0 244 243 1 1
    SNX18 GMPPB 0 0 147 454 1 1
    SNX18 RPS6KC1 0 0 0 150 1 1
    SNX18 MYO5B 0 0 342 357 1 1
    SNX18 SH3GL2 0 0 337 186 1 1
    SNX18 SMURF1 0 0 0 198 1 1
    SNX18 GAPVD1 0 0 112 176 1 1
    SNX18 VPS29 0 0 287 604 1 1
    SNX18 WASF2 0 0 0 194 1 1
    SNX18 ERBB3 0 0 0 197 1 1
    SNX18 RAB4B 0 0 0 163 1 1
    SNX18 ATG12 0 0 229 261 1 2
    SNX18 GGA3 0 0 73 312 1 1
    SNX18 ARHGAP10 0 0 226 265 1 1
    SNX18 BRAT1 0 0 205 205 1 1
    SNX18 DSCR3 0 0 0 173 1 1
    SNX18 BECN1 0 0 161 236 1 2
    SNX18 SNX4 0 0 556 332 1 1
    SNX18 ARF6 0 0 203 286 1 1
    SNX18 ITGA2 0 0 0 297 1 1
    SNX18 STXBP1 0 0 144 234 1 1
    SNX18 TRIP10 0 0 343 412 1 1
    SNX18 PIK3CB 0 600 0 618 1 1
    SNX18 PLA2R1 0 0 0 226 1 1
    SNX18 PICK1 0 0 181 181 1 1
    SNX18 SKA1 0 0 117 670 1 1
    SNX18 WAS 0 0 269 488 1 1
    SNX18 FAM109B 0 0 113 261 1 1
    SNX18 STRA6 0 0 97 190 1 1
    SNX18 SNX16 0 0 71 363 1 1
    SNX18 ADCY3 0 0 0 410 1 1
    SNX18 BIN2 0 0 155 207 1 1
    SNX18 ACOX3 0 0 142 216 1 1
    SNX18 BIN3 0 0 173 292 1 1
    SNX18 FASLG 270 0 687 762 1 1
    SNX18 PTK6 0 0 0 167 1 1
    SNX18 GAS7 0 0 134 298 1 1
    SNX18 WIPF2 0 0 217 300 1 1
    SNX18 CRKL 0 0 45 211 1 1
    SNX18 RAB11B 0 0 0 265 1 1
    SNX18 ADAM15 0 0 194 244 1 1
    SNX18 DNM1 0 0 134 406 1 1
    SNX18 NRAS 0 0 0 190 1 1
    SNX18 ARHGAP44 0 0 182 181 1 1
    SNX18 SEC11A 0 0 222 222 1 1
    SNX18 SNX2 0 0 506 655 1 1
    SNX18 C16orf62 0 0 0 191 1 1
    SNX18 KRAS 0 0 49 197 1 1
    SNX18 GFRA3 0 0 165 205 1 1
    SNX18 ENSG00000279058 0 0 0 207 1 1
    SNX18 ARFIP2 0 0 341 373 1 1
    SNX18 ERBB2 0 0 0 197 1 2
    SNX18 NME5 0 0 150 237 1 1
    SNX18 CLEC12B 0 0 0 271 1 1
    SNX18 SRGAP3 0 0 181 260 1 1
    SNX18 SNX7 0 0 469 287 1 2
    SNX18 FUCA1 0 0 0 189 1 1
    SNX18 IGF2R 0 0 62 166 1 1
    SNX18 USH2A 0 0 0 162 1 1
    SNX18 KRT18 0 0 123 362 1 1
    SNX18 BTBD2 0 0 0 153 1 1
    SNX18 GATM 0 0 96 301 1 1
    SNX18 CSMD3 0 0 0 277 1 1
    SNX18 PINK1 0 0 54 153 1 2
    SNX18 CDC16 130 0 181 270 1 1
    SNX18 KIAA1804 0 0 0 158 1 1
    SNX18 MYOF 0 0 0 185 1 1
    SNX18 EHD1 0 0 122 184 1 1
    SNX18 CCNG2 0 0 81 248 1 1
    SNX18 UBR2 270 0 0 270 1 1
    SNX18 ANP32B 0 0 157 205 1 1
    SNX18 AHI1 0 0 103 165 1 1
    SNX18 XRRA1 0 0 281 292 1 1
    SNX18 AGAP4 0 0 108 199 1 1
    SNX18 ARL15 0 0 167 266 1 1
    SNX18 SYNJ2 0 0 241 257 1 1
    SNX18 PREX2 0 0 0 150 1 1
    SNX18 AP2M1 0 0 73 535 1 1
    SNX18 DYSF 0 0 0 164 1 1
    SNX18 TYSND1 0 0 95 222 1 1
    SNX18 SNX19 0 0 0 199 1 1
    SNX18 ZFYVE1 0 0 323 353 1 2
    SNX18 SCAND1 0 0 231 323 1 1
    SNX18 PIK3C2A 0 600 108 704 1 2
    SNX18 RAB7B 0 0 218 297 1 1
    SNX18 HACE1 0 0 0 161 1 1
    SNX18 NECAP2 0 0 306 455 1 1
    SNX18 PTPRQ 0 0 0 154 1 1
    SNX18 RAC2 0 0 0 182 1 1
    SNX18 RAB11A 0 0 829 850 1 1
    SNX18 PACSIN1 0 0 166 197 1 1
    SNX18 PNP 0 0 95 151 1 1
    SNX18 BIN1 0 0 122 249 1 1
    SNX18 C16orf58 0 0 167 219 1 1
    SNX18 SEC13 0 0 134 157 1 1
    SNX18 ARHGAP26 0 0 141 185 1 1
    SNX18 RPL26L1 0 0 204 258 1 1
    SNX18 SORCS1 0 0 123 170 1 1
    SNX18 PRR13 0 0 363 507 1 1
    SNX18 EWSR1 270 0 0 270 1 1
    SNX18 WWP2 0 0 0 207 1 1
    SNX18 PRDM6 0 0 151 165 1 1
    SNX18 ATG3 0 0 150 170 1 2
    SNX18 DNMBP 0 0 193 243 1 1
    SNX18 PXK 0 0 0 248 1 1
    SNX18 RABGEF1 0 0 70 194 1 1
    SNX18 DOCK2 0 0 82 395 1 1
    SNX18 USP8 0 0 108 173 1 1
    SNX18 SMURF2 0 0 0 198 1 1
    SNX18 CDC42 0 0 247 308 1 1
    SNX18 RAB25 0 0 94 195 1 2
    SNX18 PODXL 0 0 155 154 1 1
    SNX18 EED 0 0 0 181 1 1
    SNX18 SRC 0 0 183 234 1 1
    SNX18 RAB11FIP2 0 0 194 313 1 1
    SNX18 EEA1 0 0 175 223 1 1
    SNX18 DENND5A 0 0 195 195 1 1
    SNX18 ANKLE2 0 0 181 181 1 1
    SNX18 AGAP5 0 0 0 207 1 1
    SNX18 RIMBP2 0 0 204 283 1 1
    SNX18 CCND1 0 0 0 190 1 1
    SNX18 ARHGEF7 0 0 100 163 1 1
    SNX18 SNX9 270 800 869 877 1 1
    SNX18 SERPINE2 0 0 325 325 1 1
    SNX18 CBL 270 0 74 327 1 1
    SNX18 PIK3C2B 0 600 0 682 1 1
    SNX18 IPO9 0 0 0 194 1 1
    SNX18 ZFYVE28 0 0 0 248 1 1
    SNX18 DUSP6 0 0 0 199 1 1
    SNX18 ELMO2 0 0 207 255 1 1
    SNX18 GFI1 0 0 0 158 1 1
    SNX18 RAB3IP 0 0 319 319 1 1
    SNX18 AP2B1 0 0 0 201 1 1
    SNX18 BMP5 0 0 74 235 1 1
    SNX18 ATG2A 0 0 234 234 1 2
    SNX18 CANX 0 0 54 150 1 2
    SNX18 HAPLN1 0 0 85 178 1 1
    SNX18 RASA1 0 0 90 156 1 1
    SNX18 FCHO1 0 0 377 419 1 1
    SNX18 MAP2K2 0 0 0 150 1 1
    SNX18 ANXA7 0 0 455 455 1 2
    SNX18 SNX21 0 0 0 248 1 1
    SNX18 RNASEL 0 0 0 153 1 1
    SNX18 KIAA0196 0 0 90 231 1 1
    SNX18 ITSN1 0 0 159 205 1 1
    SNX18 WIPF1 0 0 480 533 1 1
    SNX18 RRAS2 0 0 0 276 1 1
    SNX18 PACS1 0 0 469 527 1 1
    SNX18 RAB14 0 0 91 183 1 1
    SNX18 ITCH 270 0 66 412 1 1
    SNX18 WIPI2 0 0 391 390 1 2
    SNX18 LUZP1 0 0 210 210 1 1
    SNX18 WDR45B 0 0 190 190 1 1
    SNX18 ASCC1 0 0 0 164 1 1
    SNX18 ANKRD26 0 0 163 318 1 1
    SNX18 RPL18 0 0 42 188 1 1
    SNX18 ITK 0 0 139 214 1 1
    SNX18 SNX33 0 800 828 813 1 1
    SNX18 FCHO2 0 0 276 325 1 1
    SNX18 BTK 0 0 54 219 1 1
    SNX18 NEDD4L 0 0 0 267 1 1
    SNX18 WDFY3 0 0 0 171 1 2
    SNX18 PTER 0 0 0 223 1 1
    SNX18 TUBGCP6 0 0 155 154 1 1
    SNX18 APBA1 0 0 95 171 1 1
    SNX18 HECW1 0 0 0 164 1 1
    SNX18 SH3GL3 0 0 320 179 1 1
    SNX18 MAL2 0 0 156 156 1 1
    SNX18 SNX25 0 0 0 339 1 1
    SNX18 FNBP1L 0 0 358 425 1 1
    SNX18 DSCAML1 0 0 0 275 1 1
    SNX18 ITSN2 0 0 229 264 1 1
    SNX18 EOGT 0 0 0 156 1 1
    SNX18 RPL7A 0 0 123 509 1 1
    SNX18 RAB7A 0 0 218 393 1 2
    SNX18 PIK3C2G 0 600 0 634 1 1
    SNX18 SOS1 270 0 125 354 1 1
    SNX18 ATN1 0 0 0 167 1 1
    SNX18 TFRC 0 0 267 338 1 1
    SNX18 CD2AP 0 0 138 463 1 1
    SNX18 ACAP2 0 0 205 251 1 1
    SNX18 NISCH 0 0 0 223 1 1
    SNX18 SEC61G 0 0 0 189 1 1
    SNX18 KLHL29 0 0 0 299 1 1
    SNX18 SLA 0 0 193 193 1 1
    SNX18 ACAP3 0 0 261 266 1 1
    SNX18 MR1 0 0 269 274 1 1
    SNX18 MX2 0 0 0 157 1 1
    SNX18 TXLNB 0 0 0 191 1 1
    SNX18 CLTC 0 0 324 422 1 1
    SNX18 TBC1D5 0 0 208 330 1 2
    SNX18 SRGAP1 0 0 175 255 1 1
    SNX18 FNBP1 0 0 321 392 1 1
    SNX18 FLCN 0 0 0 296 1 1
    SNX18 GULP1 0 0 108 246 1 1
    SNX18 ZNF592 0 0 202 215 1 1
    SNX18 EXOC6 0 0 284 284 1 1
    SNX18 RAC3 0 0 51 190 1 1
    SNX18 GCC2 0 0 92 288 1 1
    SNX18 KIF6 0 0 163 163 1 1
    SNX18 SH3GLB1 0 0 235 249 1 2
    SNX18 IQCK 0 0 213 706 1 1
    SNX18 SOS2 270 0 96 332 1 1
    SNX18 MARK3 0 0 0 160 1 1
    SNX18 ELMO1 0 0 134 187 1 1
    SNX18 CALU 0 0 106 161 1 1
    SNX18 ARHGAP17 0 0 180 179 1 1
    SNX18 SVEP1 0 0 0 159 1 1
    SNX18 SNX11 0 0 96 584 1 1
    SNX18 TNK2 0 0 0 424 1 1
    SNX18 PIP5K1C 0 0 123 155 1 1
    SNX18 SNAI2 0 0 0 290 1 1
    SNX18 GPSM1 0 0 161 183 1 1
    SNX18 KIF17 0 0 140 176 1 1
    SNX18 CSMD2 0 0 0 159 1 1
    SNX18 UTRN 0 0 93 207 1 1
    SNX18 KIF16B 0 0 157 195 1 1
    SNX18 SNX32 0 0 501 616 1 1
    SNX18 MOXD1 0 0 0 299 1 1
    SNX18 MTSS1L 0 0 235 281 1 1
    SNX18 HOOK1 0 0 47 427 1 1
    SNX18 DUSP7 0 0 0 199 1 1
    SNX18 CSGALNACT1 0 0 136 225 1 1
    SNX18 ABCF2 0 0 290 334 1 1
    SNX18 MAP3K11 0 0 0 158 1 1
    SNX18 GFRA2 0 0 123 212 1 1
    SNX18 LGALS4 0 0 123 168 1 1
    SNX18 FAM109A 0 0 218 336 1 1
    SNX18 DNM2 270 0 902 949 1 1
    SNX18 KIF20A 0 0 91 157 1 1
    SNX18 MAP3K9 0 0 108 513 1 1
    SNX18 SNX15 0 0 241 294 1 1
    SNX18 SUPT20H 0 0 122 600 1 1
    SNX18 VPS35 0 0 231 549 1 1
    SNX18 SPPL2A 0 0 112 207 1 1
    SNX18 RYR1 0 0 0 177 1 2
    SNX18 SH3PXD2A 0 0 155 227 1 1
    SNX18 FAM92B 0 0 261 261 1 1
    SNX18 VPS26A 0 0 270 481 1 1
    SNX18 AP5Z1 0 0 69 449 1 1
    SNX18 SNX8 270 0 520 487 1 1
    SNX18 INSR 0 0 0 245 1 1
    SNX18 AGAP6 0 0 0 207 1 1
    SNX18 ATG9A 0 0 323 364 1 2
    SNX18 ZFYVE20 0 0 0 219 1 1
    SNX18 BZRAP1 0 0 181 243 1 1
    SNX18 RAB24 0 0 120 169 1 2
    SNX18 AURKA 196 0 0 196 1 2
    SNX18 BTBD3 0 0 0 153 1 1
    SNX18 RAB35 0 0 74 164 1 1
    SNX18 ZBTB7B 0 0 0 181 1 1
    SNX18 PMCH 0 0 166 172 1 1
    SNX18 GABARAPL1 0 0 249 354 1 2
    SNX18 ASAP3 0 0 235 240 1 1
    SNX18 SEMA4B 0 0 60 177 1 1
    SNX18 CTBP1 0 0 193 198 1 1
    SNX18 KIF13A 0 0 181 218 1 1
    SNX18 HAPLN3 0 0 170 190 1 1
    SNX18 SLA2 0 0 174 199 1 1
    SNX18 CTTN 0 0 125 167 1 1
    SNX18 RPS2 0 0 0 185 1 1
    SNX18 GRAP2 282 0 49 343 1 1
    SNX18 SNX10 0 0 0 388 1 2
    SNX18 ATG13 0 0 119 151 1 2
    SNX18 MAPK3 0 0 0 158 1 2
    SNX18 RYK 0 0 118 238 1 1
    SNX18 ERBB4 0 0 0 197 1 1
    SNX18 PIK3CG 0 600 0 617 1 1
    SNX18 SNX1 0 0 459 333 1 1
    SNX18 DSCAM 0 0 82 336 1 1
    SNX18 JUN 0 0 0 227 1 1
    SNX18 SNX27 0 0 71 487 1 1
    SNX18 GRB2 479 0 142 602 1 1
    SNX18 ABI1 0 0 118 169 1 1
    SNX18 ACAP1 0 0 217 222 1 1
    SNX18 WDFY2 0 0 113 178 1 1
    SNX18 TSPYL1 0 0 194 194 1 1
    SNX18 ARIH1 270 0 0 285 1 1
    SNX18 NCK2 0 0 0 316 1 1
    SNX18 MEX3B 234 0 0 234 1 1
    SNX18 SNX3 0 0 145 537 1 1
    SNX18 MFN1 0 0 0 157 1 1
    SNX18 FER 0 0 166 219 1 1
    SNX18 ADAM8 128 0 90 190 1 1
    SNX18 BAIAP2L1 0 0 181 204 1 1
    SNX18 EPS8L1 0 0 218 262 1 1
    SNX18 UTP3 0 0 74 183 1 1
    SNX18 NEDD9 0 0 72 241 1 1
    SNX18 ANGPT2 0 0 0 177 1 1
    SNX18 OSTF1 0 0 287 310 1 1
    SNX18 FRMD3 0 0 154 153 1 1
    SNX18 ALG6 0 0 0 169 1 1
    SNX18 CRK 0 0 0 207 1 1
    SNX18 RELL1 183 0 0 183 1 1
    SNX18 RYR3 0 0 0 177 1 1
    SNX18 WASL 0 0 716 801 1 1
    SNX18 PLAGL1 0 0 90 308 1 1
    SNX18 INPPL1 0 0 124 168 1 1
    SNX18 CNTN1 0 0 261 274 1 1
    SNX18 SH3GLB2 0 0 211 211 1 1
    SNX18 RER1 0 0 0 188 1 1
    SNX18 UGDH 0 0 0 186 1 1
    SNX18 CRB3 0 0 215 255 1 1
    SNX18 PLPPR1 0 0 235 235 1 1
    SNX18 ARF1 0 0 113 188 1 1
    SNX18 CKAP5 0 0 71 166 1 1
    SNX18 RYR2 0 0 0 177 1 1
    SNX18 SPSB2 0 0 204 204 1 1
    SNX18 WWP1 0 0 0 207 1 1
    SNX18 CLTCL1 0 0 50 222 1 1
    SNX18 CREB1 0 0 0 171 1 1
    SNX18 SLC22A13 0 0 0 207 1 1
    SNX18 RADIL 0 0 150 508 1 1
    SNX18 ATG14 270 0 242 423 1 2
    SNX18 ARHGEF37 0 0 261 261 1 1
    SNX18 GABARAPL2 0 0 456 548 1 2
    SNX18 PGLYRP2 0 0 46 211 1 1
    SNX18 CSMD1 0 0 90 154 1 1
    SNX18 PIK3R4 0 0 134 167 1 2
    SNX18 DHRS4 0 0 152 198 1 1
    SNX18 WDR73 0 0 224 224 1 1
    SNX18 ARHGAP4 0 0 202 279 1 1
    SNX18 INTS12 0 0 189 189 1 1
    SNX18 SNX31 0 0 66 239 1 1
    SNX18 CIAPIN1 0 0 46 301 1 1
    SNX18 FCHSD2 0 0 244 392 1 1
    SNX18 TEC 0 0 0 183 1 1
    SNX18 ELMO3 0 0 233 264 1 1
    SNX18 COPG1 0 0 0 231 1 1
    SNX18 BBS4 0 0 96 189 1 1
    SNX18 HRAS 0 0 60 206 1 1
    SNX18 MFN2 0 0 0 157 1 2
    SNX18 TBC1D30 0 0 235 236 1 1
    SNX18 NUSAP1 0 0 95 168 1 1
    SNX18 HMGN1 0 0 95 271 1 1
    SNX18 GOLT1B 0 0 0 173 1 1
    SNX18 POMGNT2 0 0 0 230 1 1
    SNX18 KIF3B 0 0 147 180 1 1
    SNX18 DHCR7 0 0 141 200 1 1
    SNX18 MTSS1 0 0 123 217 1 1
    SNX18 DNM3 0 0 0 342 1 1
    SNX18 INPP5B 0 0 232 320 1 1
    SNX18 ARFIP1 0 0 240 303 1 1
    SNX18 PACS2 0 0 257 459 1 1
    SNX18 NEDD4 0 0 85 301 1 2
    SNX18 RIMBP3 0 0 251 267 1 1
    SNX18 BAG3 0 0 0 164 1 2
    SNX18 RAB5A 0 0 281 359 1 2
    SNX18 DOCK1 0 0 108 207 1 1
    SNX18 MRPL37 0 0 219 219 1 1
    SNX18 PIK3C3 0 0 181 321 1 2
    SNX18 MPP5 0 0 180 212 1 1
    SNX18 TEPP 0 0 117 153 1 1
    SNX18 BAIAP2L2 0 0 263 263 1 1
    SNX18 CCDC53 0 0 115 154 1 1
    SNX18 TRAPPC8 0 0 265 265 1 1
    SNX18 RPL13A 0 0 54 258 1 1
    SNX18 AP1B1 0 0 160 267 1 1
    SNX18 SORT1 0 0 0 175 1 1
    SNX18 ANXA11 0 0 146 179 1 1
    SNX18 PSTPIP2 0 0 193 207 1 1
    SNX18 ZSCAN2 0 0 246 258 1 1
    SNX18 TNFRSF11B 0 0 0 230 1 1
    SNX18 RAB10 0 0 173 191 1 1
    SNX18 WHAMM 0 0 96 188 1 1
    SNX18 BTBD6 0 0 0 153 1 1
    SNX18 MRPL13 0 0 141 295 1 1
    SNX18 EPS15 0 0 233 246 1 1
    SNX18 ZBTB11 0 0 233 370 1 1
    SNX18 MARK1 0 0 0 344 1 1
    SNX18 ANKFY1 0 0 0 193 1 1
    SNX18 LAMP1 0 0 138 247 1 2
    SNX18 RAB4A 0 0 95 223 1 1
    SNX18 FES 0 0 193 244 1 1
    SNX18 PSTPIP1 0 0 218 240 1 1
    SNX18 EGFR 0 0 53 207 1 1
    SNX18 RAB8A 0 0 298 313 1 2
    SNX18 LYPD6 0 0 71 191 1 1
    SNX18 FCRL2 0 0 150 284 1 1
    SNX18 OCRL 0 0 204 335 1 1
    SNX18 CES2 0 0 0 171 1 1
    SNX18 HMHA1 0 0 172 192 1 1
    SNX18 ADAM9 271 0 456 595 1 1
    SNX18 SNX12 0 0 136 215 1 1
    SNX18 PLEKHA8 0 0 146 286 1 1
    SNX18 CHRNA3 0 0 90 183 1 1
    SNX18 ENC1 0 0 120 245 1 1
    SNX18 APRT 0 0 119 174 1 1
    SNX18 MX1 0 0 0 157 1 1
    SNX18 BDP1 0 0 195 275 1 1
    SNX18 ENPP4 0 0 206 224 1 1
    SNX18 APPL1 0 0 218 271 1 1
    SNX18 HYAL4 0 0 209 209 1 1
    SNX18 WWTR1 0 0 0 164 1 1
    SNX18 PIK3CA 0 600 0 619 1 2
    SNX18 CLTA 0 0 202 325 1 1
    SNX18 RAB11FIP5 270 0 484 608 1 1
    SNX18 ANGPTL5 0 0 0 188 1 1
    SNX18 IGF1R 0 0 0 245 1 1
    SNX18 TNK1 0 0 0 285 1 1
    SNX18 ADAM10 270 0 82 320 1 1
    SNX18 ICA1L 0 0 234 234 1 1
    SNX18 FUCA2 0 0 0 303 1 1
    SNX18 OR2B2 0 0 0 205 1 1
    SNX18 PLEKHA5 0 0 0 164 1 1
    SNX18 SERINC1 0 0 58 315 1 1
    SNX18 MTMR2 0 0 67 171 1 1
    SNX18 HIST1H2AE 270 0 0 270 1 1
    SNX18 SYNJ1 0 0 211 240 1 1
    SNX18 OPA1 0 0 0 157 1 1
    SNX18 MAP2K1 0 0 0 150 1 1
    SNX18 ARCN1 0 0 203 340 1 1
    SNX18 SRGAP2 0 0 181 260 1 1
    SNX18 DMBT1 0 0 92 185 1 1
    SNX18 STC1 0 0 74 238 1 1
    SNX18 GOLPH3 0 0 170 169 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0035091 Molecular Function phosphatidylinositol binding enables IBA
    GO:0005546 Molecular Function phosphatidylinositol-4,5-bisphosphate binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0036089 Biological Process cleavage furrow formation involved_in IBA
    GO:0036089 Biological Process cleavage furrow formation involved_in IMP
    GO:0006897 Biological Process endocytosis involved_in IBA
    GO:0006897 Biological Process endocytosis involved_in IDA
    GO:0006897 Biological Process endocytosis involved_in IMP
    GO:0016197 Biological Process endosomal transport involved_in IBA
    GO:0016197 Biological Process endosomal transport involved_in IMP
    GO:0000281 Biological Process mitotic cytokinesis involved_in IMP
    GO:0097320 Biological Process plasma membrane tubulation involved_in IBA
    GO:0043547 Biological Process positive regulation of GTPase activity involved_in IDA
    GO:2000786 Biological Process positive regulation of autophagosome assembly involved_in IMP
    GO:0015031 Biological Process protein transport involved_in IMP
    GO:0030136 Cellular Component clathrin-coated vesicle colocalizes_with IDA
    GO:0009898 Cellular Component cytoplasmic side of plasma membrane located_in IDA
    GO:0031410 Cellular Component cytoplasmic vesicle is_active_in IBA
    GO:0031410 Cellular Component cytoplasmic vesicle located_in IDA
    GO:0070062 Cellular Component extracellular exosome located_in HDA
    GO:0070062 Cellular Component extracellular exosome located_in IDA
    GO:0005886 Cellular Component plasma membrane is_active_in IBA
    GO:0055038 Cellular Component recycling endosome membrane is_active_in IMP
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    XR_007058577 1 miscRNA transcript variant X4 NC_000005 Reference
    XR_001741987 2 miscRNA transcript variant X2 NC_000005 Reference
    XM_017008997 2 mRNA transcript variant X3 NC_000005 Reference
    NM_001145427 2 mRNA transcript variant 3 NC_000005 Reference
    XM_047416679 1 mRNA transcript variant X1 NC_000005 Reference
    NM_001102575 2 mRNA transcript variant 1 NC_000005 Reference
    NM_052870 4 mRNA transcript variant 2 NC_000005 Reference