WDR45

WD repeat domain 45
General Information
Name WD repeat domain 45
Alias
  • WD repeat domain phosphoinositide-interacting protein 4
  • WD repeat domain, X-linked 1
  • WD repeat-containing protein 45
  • WD45 repeat protein interacting with phosphoinositides 4
  • neurodegeneration with brain iron accumulation 4
  • neurodegeneration with brain iron accumulation 5
Synonyms JM5 WIPI4 NBIA5 NBIA4 WDRX1 WIPI-4
Gene_family WIPI family|WD repeat domain containing
organism Homo sapiens
entrez_id 11152
location Xp11.23
transcript_count 2
exon_count 13
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]
      Stringdb WD repeat domain phosphoinositide-interacting protein 4; Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation; Belongs to the WD repeat SVP1 family
      nextProt Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    WDR45 BioGRID ATG2A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex
    WDR45 BioGRID XPO7 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID CUL3 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID ATG2B GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID RAB7A GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID RHOF GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID RAC2 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID CFAP184 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID ARSK GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID LCN8 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID HDAC11 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID MOSPD3 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID PLGRKT GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID CISD1 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID ZFYVE1 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID LHX6 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID DNAJA2 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID SLC25A11 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID SPAST GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID ATG10 GeneID BioGRID Phenotypic Enhancement
    WDR45 BioGRID ATG3 GeneID BioGRID Phenotypic Enhancement
    WDR45 BioGRID ATG7 GeneID BioGRID Phenotypic Enhancement
    WDR45 BioGRID AMOT GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    WDR45 BioGRID TMOD1 GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID RAB4A GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID RAB2A GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID PXN GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID NEFM GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID IMPDH2 GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID CLTA GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID ARF6 GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID MAP1LC3B GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID HTT GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID APEX1 GeneID BioGRID Affinity Capture-RNA
    WDR45 BioGRID GBF1 GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID EZR GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID CSNK1A1 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID DUSP26 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID XAGE1A GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID TALDO1 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID SALL2 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID DRD2 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID XPO1 GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID Atg2a GeneID BioGRID Affinity Capture-MS
    WDR45 BioGRID CEP89 GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID POC1A GeneID BioGRID Proximity Label-MS
    WDR45 BioGRID APP GeneID BioGRID Reconstituted Complex
    WDR45 BioGRID CLNS1A GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    StringDB
    A B experiments database textmining combined score hadb nhadb
    WDR45 GLUD2 0 0 159 177 1 1
    WDR45 SLC6A8 0 0 211 234 1 1
    WDR45 CDH24 0 0 181 210 1 1
    WDR45 SMARCA5 0 0 47 161 1 1
    WDR45 ABT1 0 0 170 207 1 1
    WDR45 WDR36 0 0 0 175 1 1
    WDR45 TBC1D15 0 0 142 188 1 1
    WDR45 ATG4A 0 0 120 357 1 2
    WDR45 PRRT2 0 0 188 188 1 1
    WDR45 FBXO7 0 0 213 213 1 2
    WDR45 TBC1D9B 0 0 174 375 1 1
    WDR45 RPTOR 0 0 98 160 1 2
    WDR45 TBC1D5 0 0 144 255 1 2
    WDR45 ATP6AP2 0 0 261 261 1 1
    WDR45 UBE4B 0 0 97 196 1 1
    WDR45 TRAPPC11 0 0 539 578 1 1
    WDR45 STX1B 0 0 182 181 1 1
    WDR45 DDRGK1 0 0 156 155 1 1
    WDR45 VEZF1 0 0 97 188 1 1
    WDR45 VPS18 0 0 140 199 1 1
    WDR45 FAM214A 0 0 0 396 1 1
    WDR45 WRAP53 0 0 82 203 1 1
    WDR45 PRKAB1 0 0 53 168 1 2
    WDR45 EPM2A 0 0 142 308 1 1
    WDR45 VPS35 0 0 234 234 1 1
    WDR45 CP 0 0 324 398 1 1
    WDR45 RAB9B 0 0 153 169 1 1
    WDR45 POLG 0 0 172 190 1 1
    WDR45 DCTN3 0 0 162 306 1 1
    WDR45 DCTN1 0 0 144 164 1 1
    WDR45 SPAST 129 0 180 269 1 1
    WDR45 MAP1LC3C 0 0 359 469 1 2
    WDR45 ATG16L2 0 0 294 421 1 2
    WDR45 AFF4 0 0 75 154 1 1
    WDR45 DEGS1 0 0 0 295 1 1
    WDR45 TYROBP 0 0 74 176 1 1
    WDR45 SNTA1 0 0 88 161 1 1
    WDR45 ERCC8 0 0 125 220 1 1
    WDR45 SLC2A13 0 0 0 211 1 1
    WDR45 STK35 0 0 0 206 1 1
    WDR45 SLC30A1 0 0 75 161 1 1
    WDR45 ULK4 0 0 212 261 1 1
    WDR45 SQSTM1 0 0 308 417 1 2
    WDR45 FOXG1 0 0 294 304 1 1
    WDR45 ATG13 0 0 423 533 1 2
    WDR45 ARHGDIA 0 0 0 187 1 1
    WDR45 YEATS4 0 0 0 225 1 1
    WDR45 ESYT1 0 0 134 152 1 1
    WDR45 VPS13C 0 0 347 367 1 1
    WDR45 CLEC16A 0 0 86 185 1 2
    WDR45 PSEN1 0 0 181 195 1 2
    WDR45 TFEB 0 0 261 274 1 2
    WDR45 ADSL 0 0 143 164 1 1
    WDR45 GABARAPL1 0 0 393 568 1 2
    WDR45 VPS16 0 0 163 215 1 1
    WDR45 CLNS1A 270 0 0 270 1 1
    WDR45 SLC44A4 0 0 0 162 1 1
    WDR45 WDR48 0 0 92 468 1 1
    WDR45 ZBTB7B 0 0 0 179 1 1
    WDR45 PCDH19 0 0 170 169 1 1
    WDR45 PLA2G1B 0 0 209 209 1 1
    WDR45 TOMM40 0 0 288 288 1 1
    WDR45 ATG9A 0 0 269 614 1 2
    WDR45 RAB24 0 0 265 292 1 2
    WDR45 SLC44A2 0 0 0 162 1 1
    WDR45 EI24 0 0 213 455 1 2
    WDR45 TREM2 0 0 53 197 1 1
    WDR45 ESYT2 0 0 144 162 1 1
    WDR45 DEPDC5 0 0 310 309 1 1
    WDR45 SAE1 0 0 0 171 1 1
    WDR45 ARID1B 0 0 203 203 1 1
    WDR45 MFN1 0 0 103 161 1 1
    WDR45 CSNK1A1 270 0 0 288 1 1
    WDR45 KIF3C 0 0 122 226 1 1
    WDR45 NCOA4 0 0 161 279 1 1
    WDR45 SMC1A 0 0 211 229 1 1
    WDR45 MIB2 0 0 0 224 1 1
    WDR45 C19orf12 0 0 710 762 1 2
    WDR45 VCP 0 0 112 193 1 2
    WDR45 LAMP2 0 0 246 302 1 2
    WDR45 UBXN8 0 0 0 175 1 1
    WDR45 THAP1 0 0 209 209 1 1
    WDR45 UBE3C 0 0 140 163 1 1
    WDR45 HEPH 0 0 164 255 1 1
    WDR45 KIAA0226L 0 0 155 161 1 1
    WDR45 PCCA 0 0 0 188 1 1
    WDR45 UBA6 0 0 0 171 1 1
    WDR45 ULK2 0 0 363 485 1 2
    WDR45 UTP6 0 0 0 186 1 1
    WDR45 ALG13 0 0 151 169 1 1
    WDR45 BAG5 0 0 0 154 1 1
    WDR45 SNAP29 0 0 181 202 1 2
    WDR45 MOCS3 0 0 0 171 1 1
    WDR45 SNCA 0 0 235 235 1 2
    WDR45 FYCO1 0 0 212 221 1 2
    WDR45 RAB40AL 0 0 95 232 1 1
    WDR45 TSNARE1 0 0 0 192 1 1
    WDR45 USP27X 0 0 139 246 1 1
    WDR45 WDR73 0 0 298 313 1 1
    WDR45 GLCCI1 0 0 0 297 1 1
    WDR45 PIK3R4 0 0 395 528 1 2
    WDR45 SALL2 485 0 0 485 1 1
    WDR45 CABIN1 0 0 102 178 1 1
    WDR45 FAM214B 0 0 0 208 1 1
    WDR45 GABARAPL2 0 0 391 538 1 2
    WDR45 GTPBP2 0 0 283 393 1 1
    WDR45 SLC25A11 290 0 0 290 1 1
    WDR45 ATG14 0 0 468 597 1 2
    WDR45 PNPO 0 0 320 319 1 1
    WDR45 WDR3 0 0 0 196 1 1
    WDR45 ATP1A3 0 0 249 265 1 1
    WDR45 FIG4 0 0 143 234 1 1
    WDR45 EPHX4 0 0 170 327 1 1
    WDR45 UNC13C 0 0 0 212 1 1
    WDR45 RAB40B 0 0 0 187 1 1
    WDR45 DYNC1LI1 0 0 113 211 1 1
    WDR45 MAP1LC3B2 0 0 0 206 1 2
    WDR45 DCTN2 0 0 89 207 1 1
    WDR45 MTOR 0 0 182 229 1 2
    WDR45 SMARCAD1 0 0 97 159 1 1
    WDR45 TRAPPC8 0 0 167 231 1 1
    WDR45 SLC44A3 0 0 0 162 1 1
    WDR45 MTMR7 0 0 150 223 1 1
    WDR45 ENSG00000276612 0 0 0 177 1 1
    WDR45 DCAF8L2 0 0 146 220 1 1
    WDR45 PIK3C3 0 0 459 619 1 2
    WDR45 CLN3 0 0 162 161 1 2
    WDR45 NAE1 0 0 0 171 1 1
    WDR45 POSTN 0 0 0 224 1 1
    WDR45 BAG3 0 0 52 169 1 2
    WDR45 SCN1A 0 0 294 294 1 1
    WDR45 MFN2 0 0 88 197 1 2
    WDR45 DCAF6 0 0 0 218 1 1
    WDR45 PWP2 0 0 0 184 1 1
    WDR45 MAP1LC3A 0 0 462 556 1 2
    WDR45 UBE4A 0 0 112 267 1 1
    WDR45 SERAC1 0 0 167 167 1 1
    WDR45 ZFYVE19 0 0 162 390 1 1
    WDR45 HUWE1 0 0 73 158 1 1
    WDR45 MELK 0 0 67 156 1 1
    WDR45 SLC13A5 0 0 180 179 1 1
    WDR45 DEGS2 0 0 0 203 1 1
    WDR45 CD300C 0 0 248 248 1 1
    WDR45 ARMC8 0 0 0 167 1 1
    WDR45 MCOLN1 0 0 165 190 1 1
    WDR45 LAMP1 0 0 181 181 1 2
    WDR45 TALDO1 646 0 0 646 1 1
    WDR45 BCAS3 0 0 0 164 1 2
    WDR45 MAP1A 0 0 193 254 1 1
    WDR45 PRKACG 0 0 142 160 1 1
    WDR45 SNX14 0 0 505 516 1 1
    WDR45 CDKN2AIP 0 0 161 161 1 1
    WDR45 TFR2 0 0 161 161 1 1
    WDR45 PARK7 0 0 203 274 1 1
    WDR45 FHDC1 0 0 195 204 1 1
    WDR45 ZNRF4 0 0 147 325 1 1
    WDR45 VPS39 0 0 112 172 1 1
    WDR45 KIAA1161 0 0 217 217 1 1
    WDR45 UBA1 0 0 49 178 1 1
    WDR45 SLC6A1 0 0 229 230 1 1
    WDR45 ST13 0 0 67 231 1 2
    WDR45 SYNJ1 0 0 209 226 1 1
    WDR45 STK11 0 0 97 183 1 2
    WDR45 SLC30A10 0 0 128 173 1 1
    WDR45 WDR62 0 0 194 215 1 1
    WDR45 MECP2 0 0 341 341 1 1
    WDR45 RB1CC1 0 0 519 610 1 2
    WDR45 PI3 0 0 404 404 1 1
    WDR45 FA2H 0 0 631 648 1 1
    WDR45 PARK2 0 0 218 249 1 1
    WDR45 PURA 0 0 183 183 1 1
    WDR45 TM9SF1 0 0 183 323 1 2
    WDR45 KLHL21 0 0 154 237 1 1
    WDR45 ANO3 0 0 212 229 1 1
    WDR45 UBXN7 0 0 0 175 1 1
    WDR45 DCTN4 0 0 142 265 1 1
    WDR45 SCN2A 0 0 261 261 1 1
    WDR45 AP4M1 0 0 171 269 1 1
    WDR45 AP4S1 0 0 112 171 1 1
    WDR45 ENSG00000100926 0 0 184 324 1 1
    WDR45 REPS1 0 0 293 365 1 1
    WDR45 SMCR8 0 0 90 181 1 2
    WDR45 DPM1 0 0 126 197 1 1
    WDR45 PDIK1L 0 0 0 206 1 1
    WDR45 OPTN 0 0 193 243 1 2
    WDR45 TMEM55B 0 0 167 167 1 1
    WDR45 NIPSNAP1 0 0 104 203 1 1
    WDR45 MRPS15 0 0 169 242 1 1
    WDR45 CALCOCO2 0 0 159 158 1 2
    WDR45 ATG5 0 0 459 677 1 2
    WDR45 GAN 0 0 138 274 1 1
    WDR45 PPT1 0 0 203 203 1 1
    WDR45 DYNC1H1 0 0 260 260 1 1
    WDR45 PANK1 0 0 265 315 1 1
    WDR45 ZFAND2B 0 0 195 334 1 1
    WDR45 MIB1 0 0 0 224 1 1
    WDR45 GLI1 0 0 0 188 1 1
    WDR45 ATG10 0 0 349 493 1 2
    WDR45 MAP1LC3B 55 0 278 411 1 2
    WDR45 PIGA 0 0 180 179 1 1
    WDR45 DCAF17 0 0 681 769 1 1
    WDR45 NUDC 0 0 662 682 1 1
    WDR45 STX7 0 0 57 206 1 2
    WDR45 ULK1 0 0 422 533 1 2
    WDR45 DYNLL2 0 0 134 226 1 1
    WDR45 MFSD8 0 0 166 165 1 1
    WDR45 VTI1B 0 0 113 168 1 2
    WDR45 STX12 0 0 0 192 1 1
    WDR45 ATP7B 0 0 235 320 1 1
    WDR45 TBL3 0 0 0 196 1 1
    WDR45 CTSD 0 0 167 190 1 2
    WDR45 UBE2O 0 0 114 221 1 1
    WDR45 ATP1B4 0 0 172 171 1 1
    WDR45 SLC44A1 0 0 0 162 1 1
    WDR45 ATG7 0 0 416 701 1 2
    WDR45 FMN1 0 0 0 206 1 1
    WDR45 FTL 0 0 504 538 1 1
    WDR45 GABARAP 0 0 456 613 1 2
    WDR45 PRKAA2 0 0 113 262 1 2
    WDR45 KIAA0226 0 0 167 182 1 1
    WDR45 WIPI1 0 0 901 429 1 2
    WDR45 PANK2 0 0 684 732 1 1
    WDR45 UBR3 0 0 126 228 1 1
    WDR45 TRMT61A 0 0 0 151 1 1
    WDR45 KATNAL2 0 0 144 162 1 1
    WDR45 AMBRA1 0 0 298 299 1 2
    WDR45 GOPC 0 0 113 249 1 2
    WDR45 ENSG00000279624 0 0 150 171 1 1
    WDR45 HDAC11 271 0 0 286 1 1
    WDR45 EDA2R 0 0 99 193 1 1
    WDR45 ATG12 0 0 466 676 1 2
    WDR45 VPS13A 0 0 405 422 1 1
    WDR45 KCNQ3 0 0 155 154 1 1
    WDR45 POLR3A 0 0 282 297 1 1
    WDR45 UTP18 0 0 0 196 1 1
    WDR45 STX16 0 0 0 265 1 1
    WDR45 UBA2 0 0 0 171 1 1
    WDR45 TBC1D9 0 0 0 158 1 1
    WDR45 HEPHL1 0 0 181 270 1 1
    WDR45 ATG101 0 0 423 635 1 2
    WDR45 HSPB8 0 0 58 152 1 2
    WDR45 OS9 0 0 134 165 1 1
    WDR45 PLEKHM1 0 0 142 161 1 2
    WDR45 PLA2G6 0 0 602 626 1 1
    WDR45 GABRB3 0 0 181 181 1 1
    WDR45 ATG4D 0 0 322 479 1 2
    WDR45 PANK3 0 0 135 194 1 1
    WDR45 ATG16L1 0 0 459 635 1 2
    WDR45 CNKSR2 0 0 161 167 1 1
    WDR45 C6orf106 0 0 0 166 1 1
    WDR45 ENSG00000258838 0 0 96 153 1 1
    WDR45 KIF1C 0 0 112 184 1 1
    WDR45 WDR41 0 0 96 186 1 2
    WDR45 TAF9B 0 0 181 181 1 1
    WDR45 LHX6 656 0 0 656 1 1
    WDR45 ZFAND2A 0 0 204 235 1 1
    WDR45 STAMBPL1 0 0 0 156 1 1
    WDR45 KCNQ2 0 0 216 216 1 1
    WDR45 UNC13B 0 0 64 231 1 1
    WDR45 CBLN1 0 0 91 153 1 1
    WDR45 MECR 0 0 158 157 1 1
    WDR45 DNAJC13 0 0 136 156 1 1
    WDR45 RAB39B 0 0 284 284 1 2
    WDR45 FTH1 0 0 166 177 1 1
    WDR45 TBC1D25 0 0 210 398 1 1
    WDR45 FOXK1 0 0 81 165 1 1
    WDR45 SLC44A5 0 0 0 162 1 1
    WDR45 ZGPAT 0 0 158 246 1 1
    WDR45 SPACA4 0 0 181 186 1 1
    WDR45 LOC102724159 0 0 0 184 1 1
    WDR45 TMUB1 0 0 181 191 1 1
    WDR45 SCN8A 0 0 193 193 1 1
    WDR45 ESYT3 0 0 167 185 1 1
    WDR45 USP20 0 0 90 206 1 1
    WDR45 RABGAP1 0 0 125 164 1 1
    WDR45 LRRK2 0 0 260 271 1 2
    WDR45 GRIN2B 0 0 208 208 1 1
    WDR45 VAC14 0 0 294 338 1 1
    WDR45 STXBP1 0 0 342 359 1 1
    WDR45 NUAK2 0 0 107 162 1 1
    WDR45 OTUD7B 0 0 820 820 1 1
    WDR45 MAPT 0 0 172 171 1 2
    WDR45 BECN1 0 0 403 680 1 2
    WDR45 SETX 0 0 0 205 1 1
    WDR45 LY6H 0 0 163 163 1 1
    WDR45 TBRG4 0 0 0 211 1 1
    WDR45 DCAF8L1 0 0 197 266 1 1
    WDR45 PARP4 0 0 94 171 1 1
    WDR45 UBA5 0 0 81 205 1 1
    WDR45 GNAL 0 0 171 197 1 1
    WDR45 WDTC1 0 0 0 218 1 1
    WDR45 RAB40C 0 0 0 187 1 1
    WDR45 UBR2 0 0 91 202 1 1
    WDR45 VMP1 0 0 193 313 1 2
    WDR45 USP3 0 0 81 177 1 1
    WDR45 PINK1 0 0 287 306 1 2
    WDR45 VPS37A 0 0 247 361 1 1
    WDR45 DDX56 0 0 0 155 1 1
    WDR45 ZC4H2 0 0 205 205 1 1
    WDR45 PIKFYVE 0 0 234 442 1 1
    WDR45 GBAS 0 0 218 369 1 1
    WDR45 ENSA 0 0 0 222 1 1
    WDR45 TGFBI 0 0 0 224 1 1
    WDR45 SYNGAP1 0 0 234 234 1 1
    WDR45 ATP6V1A 0 0 137 211 1 1
    WDR45 WDR81 0 0 156 301 1 1
    WDR45 UBA7 0 0 0 171 1 1
    WDR45 ATXN2 0 0 140 159 1 1
    WDR45 STAMBP 0 0 0 156 1 1
    WDR45 ATG4C 0 0 218 400 1 2
    WDR45 USP8 0 0 106 160 1 1
    WDR45 CLDN19 0 0 0 183 1 1
    WDR45 DNAJB1 0 0 71 164 1 2
    WDR45 ATG3 0 0 405 604 1 2
    WDR45 RSAD2 0 0 59 205 1 1
    WDR45 ARPP19 0 0 0 222 1 1
    WDR45 COASY 0 0 639 650 1 1
    WDR45 KBTBD7 0 0 250 255 1 1
    WDR45 RTN3 0 0 161 162 1 1
    WDR45 ATG2B 736 0 905 984 1 2
    WDR45 TBK1 0 0 122 176 1 2
    WDR45 STX17 0 0 262 404 1 2
    WDR45 UBA3 0 0 0 171 1 1
    WDR45 MBD5 0 0 156 155 1 1
    WDR45 PIGO 0 0 260 276 1 1
    WDR45 BNIP3L 0 0 167 197 1 2
    WDR45 IQSEC2 0 0 468 480 1 1
    WDR45 RAB7B 0 0 195 210 1 1
    WDR45 TSC2 0 0 167 181 1 2
    WDR45 PIK3C2A 0 0 113 211 1 2
    WDR45 ZFYVE1 0 0 465 483 1 2
    WDR45 CDKL5 0 0 466 465 1 1
    WDR45 CIZ1 0 0 134 175 1 1
    WDR45 TECPR1 0 0 264 378 1 2
    WDR45 GBA 0 0 140 170 1 1
    WDR45 PACS1 0 0 294 311 1 1
    WDR45 DNAJB2 0 0 108 223 1 1
    WDR45 XPR1 0 0 194 211 1 1
    WDR45 ATG2A 677 0 984 996 1 2
    WDR45 SPG11 0 0 379 526 1 1
    WDR45 STBD1 0 0 134 157 1 2
    WDR45 PIK3C2B 0 0 49 154 1 1
    WDR45 EPG5 0 0 517 707 1 2
    WDR45 MED13L 0 0 194 194 1 1
    WDR45 SLC35A2 0 0 181 192 1 1
    WDR45 WDR77 0 0 166 199 1 1
    WDR45 PRKAA1 0 0 0 186 1 2
    WDR45 ULK3 0 0 0 226 1 2
    WDR45 TFRC 0 0 95 151 1 1
    WDR45 ATG4B 0 0 194 411 1 2
    WDR45 RAB7A 0 0 187 214 1 2
    WDR45 RAB40A 0 0 0 187 1 1
    WDR45 PLEKHA4 270 0 0 270 1 1
    WDR45 PPCDC 0 0 163 183 1 1
    WDR45 WDR46 0 0 0 207 1 1
    WDR45 USP19 0 0 90 202 1 1
    WDR45 WDFY3 0 0 205 205 1 2
    WDR45 UVRAG 0 0 324 344 1 2
    WDR45 RNF41 0 0 93 151 1 1
    WDR45 NBR1 0 0 156 430 1 2
    WDR45 DNAJC6 0 0 155 173 1 1
    WDR45 TECPR2 0 0 505 639 1 2
    WDR45 NHLRC1 0 0 247 367 1 1
    WDR45 VPS11 0 0 181 256 1 2
    WDR45 MEF2C 0 0 159 158 1 1
    WDR45 USP5 0 0 71 171 1 1
    WDR45 UBAC2 0 0 0 183 1 1
    WDR45 UNC13A 0 0 0 212 1 1
    WDR45 ATP13A2 0 0 564 580 1 2
    WDR45 ERCC3 0 0 0 165 1 1
    WDR45 WIPI2 0 0 726 416 1 2
    WDR45 CHMP2A 0 0 183 263 1 2
    WDR45 DDX3X 0 0 166 186 1 1
    WDR45 ZFYVE26 0 0 256 370 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:1901981 Molecular Function phosphatidylinositol phosphate binding enables IDA
    GO:0080025 Molecular Function phosphatidylinositol-3,5-bisphosphate binding enables IBA
    GO:0032266 Molecular Function phosphatidylinositol-3-phosphate binding enables IBA
    GO:0032266 Molecular Function phosphatidylinositol-3-phosphate binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0019901 Molecular Function protein kinase binding enables IPI
    GO:0030674 Molecular Function protein-macromolecule adaptor activity enables IBA
    GO:0000045 Biological Process autophagosome assembly involved_in IMP
    GO:0006914 Biological Process autophagy involved_in IMP
    GO:0000422 Biological Process autophagy of mitochondrion involved_in IBA
    GO:0009267 Biological Process cellular response to starvation involved_in IDA
    GO:0061723 Biological Process glycophagy involved_in IBA
    GO:0044804 Biological Process nucleophagy involved_in IBA
    GO:0000425 Biological Process pexophagy involved_in IBA
    GO:2000786 Biological Process positive regulation of autophagosome assembly involved_in IDA
    GO:0034497 Biological Process protein localization to phagophore assembly site involved_in IBA
    GO:0005829 Cellular Component cytosol is_active_in IBA
    GO:0000407 Cellular Component phagophore assembly site located_in IDA
    GO:0034045 Cellular Component phagophore assembly site membrane is_active_in IBA
    Pathways
    Name DB ID
    Macroautophagy Reactome R-HSA-1632852
    Autophagy Reactome R-HSA-9612973
    Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway (WP4577) WikiPathways WP4577_r123500
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_007075 4 mRNA transcript variant 1 NC_000023 Reference
    NM_001029896 2 mRNA transcript variant 2 NC_000023 Reference