RRAGA

Ras related GTP binding A
General Information
Name Ras related GTP binding A
Alias
  • ras-related GTP-binding protein A
  • adenovirus E3 14.7 kDa-interacting protein 1
  • adenovirus E3-14.7K interacting protein 1
  • rag A
Synonyms RAGA FIP-1 FIP1
Gene_family Ras related GTP binding proteins
organism Homo sapiens
entrez_id 10670
location 9p22.1
transcript_count 1
exon_count 1
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Enables several functions, including GTP binding activity; protein dimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and tumor necrosis factor-mediated signaling pathway. Located in GATOR1 complex; lysosome; and nucleoplasm. Part of FNIP-folliculin RagC/D GAP. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Mar 2025]
      Stringdb Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May [...]
      nextProt (Microbial infection) May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    RRAGA BioGRID ATP6V1B2 GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID ATP6V1A GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID LAMTOR4 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID SLC38A9 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    RRAGA BioGRID RRAGC GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
    RRAGA BioGRID RRAGD GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
    RRAGA BioGRID RPTOR GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    RRAGA BioGRID LAMTOR1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Proximity Label-MS
    RRAGA BioGRID LAMTOR2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    RRAGA BioGRID LAMTOR5 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID RRAGB GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID LAMTOR3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    RRAGA BioGRID C9orf72 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID NPRL2 GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID DEPDC5 GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID NPRL3 GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID SKP2 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    RRAGA BioGRID RPA3 GeneID BioGRID Proximity Label-MS
    RRAGA BioGRID RPA2 GeneID BioGRID Proximity Label-MS
    RRAGA BioGRID RPA1 GeneID BioGRID Proximity Label-MS
    RRAGA BioGRID MIOS GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
    RRAGA BioGRID TFEB GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID TFE3 GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID MITF GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID PLEKHM1 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID PRKN GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID USP48 GeneID BioGRID Co-fractionation
    RRAGA BioGRID CTPS2 GeneID BioGRID Co-fractionation
    RRAGA BioGRID PLOD3 GeneID BioGRID Co-fractionation
    RRAGA BioGRID SPTBN1 GeneID BioGRID Co-fractionation
    RRAGA BioGRID MCM5 GeneID BioGRID Co-fractionation
    RRAGA BioGRID MCM3 GeneID BioGRID Co-fractionation
    RRAGA BioGRID ACTN1 GeneID BioGRID Co-fractionation
    RRAGA BioGRID ACTB GeneID BioGRID Co-fractionation
    RRAGA BioGRID RAB7A GeneID BioGRID Proximity Label-MS
    RRAGA BioGRID RHOQ GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID RNF152 GeneID BioGRID Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
    RRAGA BioGRID FLCN GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    RRAGA BioGRID FNIP1 GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID IFITM3 GeneID BioGRID Proximity Label-MS
    RRAGA BioGRID IFITM1 GeneID BioGRID Proximity Label-MS
    RRAGA BioGRID PPP1R1A GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID NPC2 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID EDEM1 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID ATXN3 GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID RAB9A GeneID BioGRID Proximity Label-MS
    RRAGA BioGRID EBNA-1 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID INS GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID SPRING1 GeneID BioGRID Negative Genetic
    RRAGA BioGRID FASN GeneID BioGRID Positive Genetic
    RRAGA BioGRID DYNLT1 GeneID BioGRID Two-hybrid
    RRAGA BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID AGRN GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID TBC1D7 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID TSC2 GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID CTU2 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID TSC1 GeneID BioGRID Affinity Capture-Western
    RRAGA BioGRID STAU1 GeneID BioGRID Affinity Capture-MS
    RRAGA BioGRID IL7R GeneID BioGRID Protein-RNA
    RRAGA BioGRID CDC73 GeneID BioGRID Affinity Capture-MS
    RRAGA Protein RRAGC GeneID HPRD None
    RRAGA Protein NOL8 GeneID HPRD None
    RRAGA Protein RRAGA GeneID HPRD None
    RRAGA BioGRID NOL8 GeneID BioGRID Affinity Capture-Western; Two-hybrid
    RRAGA Protein RRAGD GeneID BIND RRAGA interacts with RRAGD.
    RRAGA Protein RRAGC GeneID BIND RRAGA interacts with RRAGC.
    RRAGA Protein NOL8 GeneID BIND Nop132 interacts with RRAGA.
    StringDB
    A B experiments database textmining combined score hadb nhadb
    RRAGA ATP6V0E2 0 600 0 608 1 1
    RRAGA L3HYPDH 0 0 0 196 1 1
    RRAGA TM2D3 0 0 155 276 1 1
    RRAGA RCC2 0 0 0 173 1 1
    RRAGA ARAF 0 0 0 366 1 1
    RRAGA FKBP15 0 0 113 174 1 1
    RRAGA NOC2L 0 0 0 187 1 1
    RRAGA WDR24 0 900 651 980 1 1
    RRAGA WDR72 0 0 0 167 1 1
    RRAGA EEA1 0 0 160 276 1 1
    RRAGA MTOR 800 900 770 999 1 2
    RRAGA MAPKAP1 0 0 219 392 1 1
    RRAGA YWHAB 0 600 0 624 1 1
    RRAGA BRIX1 0 0 134 264 1 1
    RRAGA BZW2 0 0 0 204 1 1
    RRAGA VDAC3 0 0 0 246 1 1
    RRAGA FOXO3 0 0 96 294 1 2
    RRAGA RASA3 0 0 0 307 1 1
    RRAGA ABHD12 0 0 81 300 1 1
    RRAGA RAB12 0 0 57 154 1 2
    RRAGA POLR1D 0 0 74 488 1 1
    RRAGA RTN3 0 0 146 317 1 1
    RRAGA PIK3C3 0 0 376 590 1 2
    RRAGA RPS6 0 0 358 474 1 1
    RRAGA PLEK 0 0 148 201 1 1
    RRAGA GATSL2 0 900 324 935 1 1
    RRAGA PSMD7 0 0 0 161 1 1
    RRAGA WDSUB1 0 0 0 167 1 1
    RRAGA CNBP 0 0 60 171 1 1
    RRAGA RAB11A 0 0 0 582 1 1
    RRAGA RAB5A 0 0 141 164 1 2
    RRAGA RCCD1 0 0 0 220 1 1
    RRAGA RAC2 0 0 260 346 1 1
    RRAGA VAV3 0 0 43 169 1 1
    RRAGA EIF2S1 0 0 194 214 1 2
    RRAGA PRMT5 0 0 0 260 1 1
    RRAGA SKP1 0 0 136 263 1 1
    RRAGA PRKCB 0 0 112 150 1 2
    RRAGA ATP6V1H 0 600 54 642 1 1
    RRAGA HIF1A 0 0 150 203 1 2
    RRAGA YPEL5 0 0 0 217 1 1
    RRAGA SH3BP4 0 900 390 940 1 1
    RRAGA CRYBB2 0 0 91 188 1 1
    RRAGA MITF 0 0 166 506 1 1
    RRAGA SLC1A7 0 0 394 456 1 1
    RRAGA ASAP1 0 0 0 163 1 1
    RRAGA ARF3 0 0 137 254 1 1
    RRAGA LAPTM4B 0 0 184 190 1 1
    RRAGA MTFP1 0 0 190 193 1 1
    RRAGA SEC13 0 900 468 970 1 1
    RRAGA RANBP17 0 0 0 154 1 1
    RRAGA CDC73 270 0 0 287 1 1
    RRAGA BOLA2-SMG1P6 0 0 0 440 1 1
    RRAGA ATP6V1B1 0 600 0 699 1 1
    RRAGA TEP1 0 0 0 189 1 1
    RRAGA HRAS 0 0 76 217 1 1
    RRAGA ENSG00000270249 0 0 0 267 1 1
    RRAGA SLC38A1 0 0 142 190 1 1
    RRAGA IFRD2 0 0 0 207 1 1
    RRAGA MRFAP1 0 0 0 151 1 1
    RRAGA MAF1 0 900 76 908 1 1
    RRAGA PPP2R3B 0 0 0 635 1 1
    RRAGA F2R 0 0 61 273 1 1
    RRAGA PRKAG1 0 900 0 911 1 1
    RRAGA ERAP1 0 0 96 438 1 1
    RRAGA TRRAP 0 0 0 266 1 1
    RRAGA RAB7B 0 0 293 407 1 1
    RRAGA PIK3C2A 0 0 0 266 1 2
    RRAGA IBTK 0 0 0 173 1 1
    RRAGA TGFBRAP1 0 0 0 454 1 1
    RRAGA TSC2 486 900 700 993 1 2
    RRAGA VDAC1 0 0 54 192 1 2
    RRAGA SGK3 0 0 0 281 1 1
    RRAGA ATP6V1C2 0 600 0 609 1 1
    RRAGA RAN 0 0 93 230 1 1
    RRAGA ALS2 0 0 0 220 1 1
    RRAGA WDR73 0 0 0 188 1 1
    RRAGA CD4 0 0 71 168 1 1
    RRAGA ATF4 0 0 174 175 1 2
    RRAGA SLC9A1 0 0 52 198 1 1
    RRAGA PIK3R4 0 0 210 275 1 2
    RRAGA AKT1 0 900 402 951 1 2
    RRAGA CDH13 0 0 0 213 1 1
    RRAGA FYCO1 0 0 204 442 1 2
    RRAGA SF3A3 0 0 0 199 1 1
    RRAGA C17orf59 0 0 288 288 1 1
    RRAGA ELMO3 0 0 0 175 1 1
    RRAGA LIPM 0 0 148 182 1 1
    RRAGA PLK4 0 0 0 228 1 1
    RRAGA CHST15 0 0 448 448 1 1
    RRAGA ATG14 0 0 222 235 1 2
    RRAGA ARF4 0 0 0 207 1 1
    RRAGA LARS2 0 0 503 773 1 1
    RRAGA GAPDH 0 0 170 169 1 2
    RRAGA HECTD4 0 0 0 220 1 1
    RRAGA FGFR2 0 0 0 188 1 1
    RRAGA CHMP1B 0 0 94 169 1 1
    RRAGA SLC36A1 0 0 359 380 1 1
    RRAGA ATP7A 0 0 97 161 1 1
    RRAGA NARS 0 0 74 166 1 1
    RRAGA MAP2K7 0 0 370 370 1 1
    RRAGA RXFP1 0 0 63 275 1 1
    RRAGA PPP2R3C 0 0 0 190 1 1
    RRAGA SMG1 0 0 93 470 1 1
    RRAGA PRR5 0 0 341 341 1 1
    RRAGA FKBP8 0 0 357 380 1 1
    RRAGA SLC38A7 0 0 345 366 1 1
    RRAGA RAP1A 0 0 60 157 1 1
    RRAGA GABARAPL2 0 0 108 206 1 2
    RRAGA SEH1L 0 900 556 973 1 1
    RRAGA ARF1 0 0 364 446 1 1
    RRAGA RHOC 0 0 0 219 1 1
    RRAGA EIF4EBP1 0 900 519 954 1 1
    RRAGA ESRRA 0 0 306 306 1 1
    RRAGA GRB10 0 0 181 186 1 1
    RRAGA INO80 0 0 0 150 1 1
    RRAGA CDC16 0 0 157 167 1 1
    RRAGA LTV1 0 0 134 505 1 1
    RRAGA HERC1 0 0 0 220 1 1
    RRAGA SLC38A9 998 600 895 999 1 1
    RRAGA LAMTOR5 998 600 597 999 1 1
    RRAGA CTSO 0 0 0 196 1 1
    RRAGA PLEKHF1 0 0 0 328 1 2
    RRAGA VEGFB 0 0 0 212 1 1
    RRAGA ITM2B 0 0 66 278 1 1
    RRAGA YME1L1 0 0 0 189 1 1
    RRAGA MAP3K1 0 0 0 212 1 1
    RRAGA C12orf66 0 900 459 944 1 1
    RRAGA ATP6V1A 913 600 211 980 1 1
    RRAGA ANKRD6 0 0 0 186 1 1
    RRAGA OR2L8 0 0 213 213 1 1
    RRAGA TFEC 0 0 144 238 1 1
    RRAGA OXA1L 0 0 0 188 1 1
    RRAGA RAB7A 0 0 304 557 1 2
    RRAGA TMEM150C 0 0 170 184 1 1
    RRAGA ACPP 0 0 0 161 1 1
    RRAGA BCAP31 0 0 61 317 1 1
    RRAGA ITSN2 0 0 0 203 1 1
    RRAGA DYNLT1 237 0 454 566 1 2
    RRAGA LAMTOR2 998 600 843 999 1 1
    RRAGA FKBP1C 0 0 43 186 1 1
    RRAGA ITFG2 0 900 451 943 1 1
    RRAGA SPATA6L 0 0 113 168 1 1
    RRAGA PLEKHA4 270 0 0 270 1 1
    RRAGA RUFY4 0 0 0 328 1 2
    RRAGA RPS6KA2 0 0 165 294 1 1
    RRAGA NGDN 0 0 210 210 1 1
    RRAGA MAP4K1 0 0 0 439 1 1
    RRAGA VPS39 0 0 372 777 1 1
    RRAGA EFNA5 0 0 817 817 1 1
    RRAGA ERAP2 0 0 135 358 1 1
    RRAGA RUFY1 0 0 0 328 1 1
    RRAGA PIGG 0 0 0 153 1 1
    RRAGA ATP12A 0 0 321 339 1 1
    RRAGA LAMTOR3 981 600 618 997 1 1
    RRAGA PIK3C2G 0 0 0 266 1 1
    RRAGA ACER2 0 0 173 188 1 1
    RRAGA MAPK1 0 0 97 175 1 2
    RRAGA AKT2 0 0 65 271 1 1
    RRAGA IGF1 0 0 214 214 1 1
    RRAGA LNPEP 0 0 66 376 1 1
    RRAGA ENSG00000272772 0 0 0 157 1 1
    RRAGA UVRAG 0 0 282 295 1 2
    RRAGA RHEBL1 0 0 263 339 1 1
    RRAGA NHLRC2 0 0 162 219 1 1
    RRAGA FGD5 0 0 0 328 1 1
    RRAGA LARP1 0 0 123 178 1 1
    RRAGA RB1CC1 0 600 181 694 1 2
    RRAGA BOLA2 0 0 0 440 1 1
    RRAGA NOL8 270 0 779 868 1 1
    RRAGA STK11 0 0 325 453 1 2
    RRAGA BSPH1 0 0 181 181 1 1
    RRAGA RAB1B 0 0 0 158 1 2
    RRAGA TAF7 0 0 0 257 1 1
    RRAGA PPP2R5C 0 0 0 187 1 1
    RRAGA SLC1A6 0 0 0 256 1 1
    RRAGA HERC2 0 0 0 220 1 1
    RRAGA SLC1A5 0 0 134 225 1 1
    RRAGA ILK 0 0 54 202 1 1
    RRAGA DDX47 0 0 95 183 1 1
    RRAGA STK32B 0 0 0 210 1 1
    RRAGA ECHDC2 0 0 123 163 1 1
    RRAGA ARL8B 0 0 261 306 1 1
    RRAGA SLC1A3 0 0 0 256 1 1
    RRAGA TMEM192 0 0 227 226 1 1
    RRAGA MLX 0 0 95 170 1 1
    RRAGA ITGAE 0 0 242 241 1 1
    RRAGA MYC 0 0 207 207 1 2
    RRAGA RASAL1 0 0 0 206 1 1
    RRAGA STK32C 0 0 0 210 1 1
    RRAGA VPS11 0 0 0 158 1 2
    RRAGA LARS 0 0 507 769 1 1
    RRAGA IGF1R 0 0 90 186 1 1
    RRAGA ATP6V1G3 0 600 45 610 1 1
    RRAGA SMPDL3B 0 0 0 189 1 1
    RRAGA TMEM60 0 0 0 167 1 1
    RRAGA TAF7L 0 0 96 211 1 1
    RRAGA MAP4K2 0 0 0 439 1 1
    RRAGA ARHGEF28 0 0 0 208 1 1
    RRAGA RUVBL2 0 0 0 196 1 1
    RRAGA FKBP1B 0 0 0 180 1 1
    RRAGA RICTOR 0 0 466 709 1 2
    RRAGA IGBP1 0 0 0 440 1 1
    RRAGA FNIP2 800 900 469 988 1 1
    RRAGA EEF2 0 0 233 246 1 1
    RRAGA ATP6V1G1 0 600 0 608 1 1
    RRAGA ITCH 0 0 52 259 1 1
    RRAGA URB1 0 0 151 150 1 1
    RRAGA SF3A2 0 0 0 300 1 1
    RRAGA UBL3 0 0 0 642 1 1
    RRAGA RBM12B 0 0 181 181 1 1
    RRAGA TM2D1 0 0 150 252 1 1
    RRAGA WIPI2 0 0 136 155 1 2
    RRAGA PIK3CA 0 0 81 346 1 2
    RRAGA ITSN1 0 0 0 202 1 1
    RRAGA BCAT2 0 0 90 217 1 1
    RRAGA RHEB 0 600 810 967 1 2
    RRAGA DDIT4 0 0 397 396 1 1
    RRAGA APAF1 0 0 0 167 1 1
    RRAGA NGFRAP1 0 0 160 500 1 1
    RRAGA PPP2R5E 0 0 0 230 1 1
    RRAGA EEF1E1 0 0 0 151 1 1
    RRAGA SZT2 0 900 401 938 1 1
    RRAGA RPGR 0 0 0 220 1 1
    RRAGA PPP2R3A 0 0 0 361 1 1
    RRAGA NPRL2 892 900 696 999 1 1
    RRAGA POLR2J2 0 0 0 161 1 1
    RRAGA CAMKK2 0 0 325 336 1 2
    RRAGA KCTD16 0 0 49 167 1 1
    RRAGA KCTD10 0 0 42 151 1 1
    RRAGA RRAS2 0 0 0 169 1 1
    RRAGA UBB 0 600 0 600 1 1
    RRAGA MCOLN1 0 0 193 352 1 1
    RRAGA ELMO2 0 0 0 230 1 1
    RRAGA LAMTOR4 998 600 681 999 1 1
    RRAGA NET1 0 0 0 209 1 1
    RRAGA GSTT2B 0 0 0 151 1 1
    RRAGA PDPK1 0 0 167 252 1 2
    RRAGA RAB9A 129 0 104 318 1 2
    RRAGA VDAC2 0 0 0 392 1 1
    RRAGA C7orf60 0 900 368 935 1 1
    RRAGA ATP6V0D1 0 600 0 668 1 1
    RRAGA MAP4K3 0 0 272 639 1 1
    RRAGA EIF2AK4 0 0 233 482 1 1
    RRAGA GAA 0 0 150 211 1 2
    RRAGA SESN1 0 900 505 961 1 2
    RRAGA ATP6V0C 0 600 113 678 1 2
    RRAGA ENSG00000273637 800 0 0 939 1 1
    RRAGA KCNA1 0 0 306 306 1 1
    RRAGA TP53 0 0 180 179 1 2
    RRAGA SGK1 0 0 264 448 1 1
    RRAGA IRS1 0 0 210 294 1 1
    RRAGA PIK3C2B 0 0 0 266 1 1
    RRAGA B4GALT7 0 0 101 369 1 1
    RRAGA DRD1 0 0 0 173 1 1
    RRAGA CFLAR 0 0 66 159 1 1
    RRAGA RPS6KB1 0 900 556 971 1 2
    RRAGA YWHAQ 0 0 97 283 1 1
    RRAGA ADRB2 0 0 0 284 1 1
    RRAGA REM1 0 0 0 218 1 1
    RRAGA METAP2 0 0 262 283 1 1
    RRAGA MARS 0 0 0 208 1 1
    RRAGA EIF4E 0 900 321 935 1 1
    RRAGA CHMP4B 0 0 150 275 1 2
    RRAGA PPP2CA 0 0 67 171 1 1
    RRAGA LAMP1 0 0 335 438 1 2
    RRAGA PRKDC 0 0 0 440 1 2
    RRAGA RANBP3 0 0 0 175 1 1
    RRAGA STAU1 270 0 0 285 1 1
    RRAGA PRKAA1 0 900 0 927 1 2
    RRAGA ELMOD1 0 0 127 181 1 1
    RRAGA RCC1 0 0 193 625 1 1
    RRAGA FLT3LG 0 0 297 297 1 1
    RRAGA DENND4C 0 0 141 203 1 1
    RRAGA ARF5 0 0 0 155 1 1
    RRAGA RCBTB1 0 0 0 220 1 1
    RRAGA RAB10 0 0 392 404 1 1
    RRAGA ATP6V1F 0 600 0 613 1 1
    RRAGA MAP3K7 0 0 76 177 1 1
    RRAGA MED9 0 0 0 187 1 1
    RRAGA PPP2R5D 0 0 0 187 1 1
    RRAGA ATR 0 0 43 268 1 1
    RRAGA SLC7A5 0 0 283 301 1 1
    RRAGA RAB9B 0 0 0 196 1 1
    RRAGA TTI1 0 0 235 239 1 1
    RRAGA RAP2B 0 0 150 237 1 1
    RRAGA POLR2J3 0 0 0 161 1 1
    RRAGA PRKAG3 0 900 113 922 1 1
    RRAGA DAP 0 0 202 202 1 2
    RRAGA HSD17B11 0 0 0 189 1 1
    RRAGA SH3PXD2A 0 0 0 266 1 1
    RRAGA WDR55 0 0 0 151 1 1
    RRAGA C6orf211 0 0 0 181 1 1
    RRAGA CTSD 0 0 156 177 1 2
    RRAGA TRIM63 0 0 141 200 1 1
    RRAGA MIOS 270 900 608 981 1 1
    RRAGA PPP2R5A 0 0 0 173 1 1
    RRAGA GRWD1 0 0 113 174 1 1
    RRAGA STK32A 0 0 0 210 1 1
    RRAGA UNC45B 0 0 86 328 1 1
    RRAGA BOLA2B 0 0 0 440 1 1
    RRAGA IL10 0 0 0 292 1 1
    RRAGA NIPSNAP3B 0 0 170 191 1 1
    RRAGA PKDREJ 0 0 144 218 1 1
    RRAGA ATP6V0A1 0 0 112 283 1 1
    RRAGA SLC3A2 0 0 217 234 1 1
    RRAGA WDR7 0 0 0 182 1 1
    RRAGA RHOB 0 0 0 235 1 1
    RRAGA ATG7 0 0 202 258 1 2
    RRAGA OR5H2 0 0 244 243 1 1
    RRAGA PRKAA2 0 900 329 949 1 2
    RRAGA TELO2 0 0 123 199 1 1
    RRAGA XPO7 0 0 0 185 1 1
    RRAGA CRYBA1 0 0 107 172 1 1
    RRAGA SGK2 0 0 0 281 1 1
    RRAGA RRAGB 913 900 890 991 1 2
    RRAGA PI4KB 0 0 0 266 1 1
    RRAGA EIF4A1 0 0 138 208 1 1
    RRAGA TFPT 0 0 151 150 1 1
    RRAGA WIPI1 0 0 141 160 1 2
    RRAGA PTEN 0 0 278 476 1 2
    RRAGA GABARAP 0 0 143 206 1 2
    RRAGA DCAF7 0 0 107 196 1 1
    RRAGA IRF4 0 0 0 245 1 1
    RRAGA CTNS 0 0 438 443 1 1
    RRAGA SREBF1 0 0 161 201 1 2
    RRAGA SLC36A4 0 0 386 406 1 1
    RRAGA ENSG00000267318 0 0 0 210 1 1
    RRAGA SH3PXD2B 0 0 0 266 1 1
    RRAGA UBA52 0 600 0 600 1 1
    RRAGA ENSG00000272822 0 0 0 155 1 1
    RRAGA ELMO1 0 0 117 451 1 1
    RRAGA OLFML2B 0 0 0 186 1 1
    RRAGA EIF4EBP3 0 0 385 438 1 1
    RRAGA IMPA2 0 0 0 189 1 1
    RRAGA LGALS8 0 0 453 453 1 1
    RRAGA ARL17A 0 0 0 155 1 1
    RRAGA MADD 0 0 283 282 1 1
    RRAGA PRKG2 0 0 72 273 1 1
    RRAGA KLHL22 0 0 241 246 1 1
    RRAGA AMBRA1 0 0 150 181 1 2
    RRAGA NLK 0 0 90 152 1 1
    RRAGA RNF183 0 0 127 167 1 1
    RRAGA DHX36 0 0 600 609 1 1
    RRAGA RAC3 0 0 0 152 1 1
    RRAGA RPS6KA3 0 0 170 436 1 1
    RRAGA KLHDC8B 0 0 201 490 1 1
    RRAGA SESN3 0 0 418 569 1 1
    RRAGA ST8SIA6 0 0 118 182 1 1
    RRAGA FLCN 800 900 856 998 1 1
    RRAGA OPTN 0 0 125 186 1 2
    RRAGA SLC1A2 0 0 0 256 1 1
    RRAGA EOMES 0 0 306 306 1 1
    RRAGA POLR2J 0 0 0 161 1 1
    RRAGA DDIT4L 0 0 155 154 1 1
    RRAGA PRKAB2 0 900 45 908 1 1
    RRAGA LIPJ 0 0 134 161 1 1
    RRAGA ATP4A 0 0 394 411 1 1
    RRAGA PRKAG2 0 900 0 912 1 1
    RRAGA ACAD10 0 0 329 398 1 1
    RRAGA DYRK3 0 0 0 162 1 1
    RRAGA VARS 0 0 0 212 1 1
    RRAGA ATP6V1D 0 600 161 705 1 1
    RRAGA RPTOR 998 900 989 999 1 2
    RRAGA NEK9 0 0 0 220 1 1
    RRAGA ATG5 0 0 213 288 1 2
    RRAGA ARHGEF3 0 0 46 213 1 1
    RRAGA ENSG00000228049 0 0 0 161 1 1
    RRAGA SESN2 0 900 602 969 1 2
    RRAGA MAP1LC3B 0 0 218 228 1 2
    RRAGA KPTN 0 900 421 939 1 1
    RRAGA UBC 0 600 56 606 1 1
    RRAGA SCIN 0 0 71 281 1 1
    RRAGA FAM136A 0 0 0 190 1 1
    RRAGA CTU2 163 0 0 163 1 1
    RRAGA FKBP1A 0 0 308 412 1 2
    RRAGA OR5H6 0 0 283 282 1 1
    RRAGA RPS6KB2 0 0 180 499 1 2
    RRAGA TSG101 0 0 0 163 1 2
    RRAGA ESPN 0 0 0 190 1 1
    RRAGA RCBTB2 0 0 0 220 1 1
    RRAGA RASA4 0 0 0 206 1 1
    RRAGA AKT3 0 0 92 292 1 1
    RRAGA PRKAB1 0 900 0 907 1 2
    RRAGA SKP2 0 800 180 832 1 1
    RRAGA IKBKG 0 0 113 268 1 1
    RRAGA RUVBL1 0 0 92 198 1 1
    RRAGA FNIP1 0 900 559 956 1 1
    RRAGA TBP 0 0 0 225 1 1
    RRAGA PCBP1 0 0 0 151 1 1
    RRAGA RALA 0 0 73 168 1 1
    RRAGA PLD1 0 0 161 175 1 1
    RRAGA ULK1 0 600 327 762 1 2
    RRAGA ATP6AP1 0 0 181 181 1 1
    RRAGA PRKCA 0 0 150 282 1 1
    RRAGA RPS6KA1 0 0 282 393 1 1
    RRAGA ATP6V0A2 0 0 61 241 1 1
    RRAGA ATP6V0D2 0 600 0 793 1 1
    RRAGA MCOLN2 0 0 0 229 1 1
    RRAGA EIF4A2 0 0 134 194 1 1
    RRAGA ARFGAP3 0 0 0 173 1 1
    RRAGA MLST8 800 900 596 995 1 2
    RRAGA WDR35 0 0 477 477 1 1
    RRAGA DEPDC5 932 900 856 999 1 1
    RRAGA MCOLN3 0 0 52 238 1 1
    RRAGA NRAS 0 0 0 169 1 1
    RRAGA TM2D2 0 0 134 307 1 1
    RRAGA TFE3 0 0 390 573 1 1
    RRAGA IGFBP3 0 0 0 192 1 1
    RRAGA RND2 0 0 0 153 1 1
    RRAGA ENSG00000270024 0 0 0 281 1 1
    RRAGA SLC25A33 0 0 0 189 1 1
    RRAGA TCIRG1 0 600 61 663 1 1
    RRAGA AGRN 270 0 0 270 1 1
    RRAGA WBSCR16 0 0 0 220 1 1
    RRAGA DTNBP1 0 0 0 187 1 1
    RRAGA RSPH4A 0 0 0 188 1 1
    RRAGA RASD1 0 0 69 165 1 1
    RRAGA PGD 0 0 0 152 1 1
    RRAGA FOXO1 0 0 166 166 1 2
    RRAGA KRAS 0 0 74 220 1 1
    RRAGA SERGEF 0 0 0 220 1 1
    RRAGA LAMP2 0 0 427 448 1 2
    RRAGA AKAP11 0 0 0 208 1 1
    RRAGA WDR59 0 900 557 974 1 1
    RRAGA NFKBIL1 0 0 87 323 1 1
    RRAGA AKAP8 0 0 86 294 1 1
    RRAGA RSPH6A 0 0 144 276 1 1
    RRAGA RAB11B 0 0 0 220 1 1
    RRAGA DEPTOR 0 900 556 957 1 1
    RRAGA RRAGC 998 900 989 999 1 1
    RRAGA ARHGEF16 0 0 0 158 1 1
    RRAGA NPRL3 932 900 719 998 1 1
    RRAGA EIF1 0 0 83 171 1 1
    RRAGA PPP1R1A 270 0 0 270 1 1
    RRAGA TMEM11 0 0 764 765 1 1
    RRAGA RAB3D 0 0 183 183 1 1
    RRAGA KANSL2 0 0 0 237 1 1
    RRAGA SLC16A4 0 0 56 201 1 1
    RRAGA TSC1 270 900 469 971 1 2
    RRAGA RRAGD 992 900 921 999 1 1
    RRAGA LPIN1 0 0 235 235 1 2
    RRAGA DCAF10 0 0 0 167 1 1
    RRAGA ATP6V0A4 0 0 92 266 1 1
    RRAGA DENND6A 0 0 216 237 1 1
    RRAGA EEF2K 0 0 206 218 1 2
    RRAGA RASA4B 0 0 0 206 1 1
    RRAGA IL2 0 0 0 294 1 1
    RRAGA EIF2AK1 0 0 0 248 1 1
    RRAGA ATP6V0E1 0 600 75 622 1 1
    RRAGA AKT1S1 800 900 556 991 1 1
    RRAGA EIF4EBP2 0 0 350 552 1 1
    RRAGA SLC16A3 0 0 62 164 1 1
    RRAGA BECN1 0 0 194 299 1 2
    RRAGA EEF1G 0 0 0 207 1 1
    RRAGA CHEK1 0 0 44 202 1 1
    RRAGA NPC2 360 0 0 360 1 1
    RRAGA C7orf62 0 0 0 163 1 1
    RRAGA PIK3CG 0 0 0 282 1 1
    RRAGA ARL17B 0 0 0 155 1 1
    RRAGA ULK2 0 0 150 283 1 2
    RRAGA ZC3H8 0 0 0 186 1 1
    RRAGA SLC38A10 0 0 48 214 1 1
    RRAGA SPATA4 0 0 46 163 1 1
    RRAGA AUH 0 0 103 168 1 1
    RRAGA PIK3CB 0 0 0 282 1 1
    RRAGA INS 0 0 321 321 1 1
    RRAGA ATG13 0 600 343 768 1 2
    RRAGA TMOD1 0 0 67 208 1 1
    RRAGA ACTB 0 0 141 166 1 1
    RRAGA SLC1A1 0 0 0 256 1 1
    RRAGA AK6 0 0 0 207 1 1
    RRAGA ATP6V1G2 0 600 0 608 1 1
    RRAGA RPS6KA6 0 0 0 190 1 1
    RRAGA NIP7 0 0 675 696 1 1
    RRAGA MAPK3 0 0 146 214 1 2
    RRAGA GPR137B 0 0 112 167 1 1
    RRAGA PRR5L 0 0 180 198 1 1
    RRAGA RAD21 0 0 0 233 1 1
    RRAGA BNIP3 0 0 162 189 1 2
    RRAGA SQSTM1 0 0 261 261 1 2
    RRAGA VEGFC 0 0 0 192 1 1
    RRAGA TFEB 0 0 556 604 1 2
    RRAGA DDX4 0 0 0 173 1 1
    RRAGA ATG101 0 600 137 657 1 2
    RRAGA RNF152 270 800 505 970 1 1
    RRAGA COPS8 0 0 107 161 1 1
    RRAGA FGD6 0 0 0 328 1 1
    RRAGA EPHA7 0 0 73 237 1 1
    RRAGA ATP6V1B2 913 600 268 980 1 1
    RRAGA EIF4B 0 0 350 394 1 1
    RRAGA RANGAP1 0 0 0 211 1 1
    RRAGA PIK3CD 0 0 0 282 1 1
    RRAGA RAB1A 0 0 236 433 1 2
    RRAGA RASA2 0 0 0 307 1 1
    RRAGA TBC1D7 270 0 519 636 1 2
    RRAGA USP6 0 0 166 165 1 1
    RRAGA PI4KA 0 0 0 266 1 1
    RRAGA PLEKHF2 0 0 0 328 1 1
    RRAGA WDR61 0 0 0 167 1 1
    RRAGA RAB35 0 0 166 203 1 1
    RRAGA ATP6V0B 0 600 0 644 1 1
    RRAGA MAP4K5 0 0 0 525 1 1
    RRAGA RALB 0 0 56 153 1 1
    RRAGA ATP6V1E1 0 600 0 615 1 1
    RRAGA LAMTOR1 998 600 905 999 1 1
    RRAGA YWHAH 0 0 118 160 1 1
    RRAGA GABARAPL1 0 0 109 174 1 2
    RRAGA XRCC5 0 0 0 171 1 1
    RRAGA RIMS3 0 0 0 203 1 1
    RRAGA GATSL3 0 900 631 964 1 1
    RRAGA ATP6V1E2 0 600 0 600 1 1
    RRAGA OAT 0 0 74 216 1 1
    RRAGA GANC 0 0 134 266 1 1
    RRAGA RPS27A 0 600 0 600 1 1
    RRAGA EIF4G1 0 0 232 261 1 2
    RRAGA RHOA 0 0 129 306 1 1
    RRAGA PPP6C 0 0 0 288 1 1
    RRAGA ERCC1 0 0 0 258 1 1
    RRAGA KCTD8 0 0 45 167 1 1
    RRAGA B4GALT5 0 0 0 183 1 1
    RRAGA ZZEF1 0 0 0 220 1 1
    RRAGA WDR41 0 0 142 195 1 2
    RRAGA SESTD1 0 0 134 188 1 1
    RRAGA TAF9B 0 0 108 406 1 1
    RRAGA WNT2 0 0 0 188 1 1
    RRAGA UBE2N 0 600 0 608 1 1
    RRAGA SLC38A2 0 0 260 284 1 1
    RRAGA ATP6V1C1 0 600 123 660 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005525 Molecular Function GTP binding enables IBA
    GO:0005525 Molecular Function GTP binding enables IDA
    GO:0003924 Molecular Function GTPase activity enables IBA
    GO:0003924 Molecular Function GTPase activity enables IDA
    GO:0051219 Molecular Function phosphoprotein binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0046982 Molecular Function protein heterodimerization activity enables IPI
    GO:0042803 Molecular Function protein homodimerization activity enables IDA
    GO:0043495 Molecular Function protein-membrane adaptor activity enables IDA
    GO:0031625 Molecular Function ubiquitin protein ligase binding enables IPI
    GO:0006915 Biological Process apoptotic process involved_in IEA
    GO:0034198 Biological Process cellular response to amino acid starvation involved_in IMP
    GO:0071230 Biological Process cellular response to amino acid stimulus involved_in IMP
    GO:0031669 Biological Process cellular response to nutrient levels involved_in IDA
    GO:0009267 Biological Process cellular response to starvation involved_in IBA
    GO:0042593 Biological Process glucose homeostasis involved_in IEA
    GO:0035556 Biological Process intracellular signal transduction involved_in IDA
    GO:0010507 Biological Process negative regulation of autophagy involved_in IBA
    GO:0010507 Biological Process negative regulation of autophagy involved_in IMP
    GO:0032008 Biological Process positive regulation of TOR signaling involved_in NAS
    GO:1904263 Biological Process positive regulation of TORC1 signaling involved_in IBA
    GO:1904263 Biological Process positive regulation of TORC1 signaling involved_in IDA
    GO:1904263 Biological Process positive regulation of TORC1 signaling involved_in IMP
    GO:0008104 Biological Process protein localization involved_in IMP
    GO:0061462 Biological Process protein localization to lysosome involved_in IDA
    GO:0072657 Biological Process protein localization to membrane involved_in IDA
    GO:0033209 Biological Process tumor necrosis factor-mediated signaling pathway involved_in IDA
    GO:1990877 Cellular Component FNIP-folliculin RagC/D GAP part_of IDA
    GO:1990130 Cellular Component GATOR1 complex part_of IDA
    GO:1990131 Cellular Component Gtr1-Gtr2 GTPase complex part_of IBA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0005765 Cellular Component lysosomal membrane located_in HDA
    GO:0005765 Cellular Component lysosomal membrane is_active_in IDA
    GO:0005764 Cellular Component lysosome is_active_in IBA
    GO:0005764 Cellular Component lysosome located_in IDA
    GO:0005654 Cellular Component nucleoplasm located_in IDA
    GO:0005634 Cellular Component nucleus is_active_in IBA
    GO:0005634 Cellular Component nucleus located_in IDA
    Pathways
    Name DB ID
    2q37 copy number variation syndrome (WP5224) WikiPathways WP5224_r122740
    Target of rapamycin signaling (WP1471) WikiPathways WP1471_r123616
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_006570 5 mRNA None NC_000009 Reference