CAMKK2

calcium/calmodulin dependent protein kinase kinase 2
General Information
Name calcium/calmodulin dependent protein kinase kinase 2
Alias
  • calcium/calmodulin-dependent protein kinase kinase 2
  • CAMKK beta protein
  • caM-KK 2
  • caM-KK beta
  • caM-kinase kinase 2
  • caM-kinase kinase beta
  • calcium/calmodulin-dependent protein kinase beta
  • calcium/calmodulin-dependent protein kinase kinase 2, beta
Synonyms CAMKK KIAA0787 CAMKKB MGC15254
Gene_family None
organism Homo sapiens
entrez_id 10645
location 12q24.31
transcript_count 24
exon_count 20
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
      Stringdb Calcium/calmodulin-dependent protein kinase kinase 2; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Efficiently phosphorylates 5'-AMP- activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals [...]
      nextProt May promote neurite elongation, while isoform 1 may promoter neurite branching.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    CAMKK2 BioGRID CDCA8 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID GMNN GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID HSPA4L GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID FEZF1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID YTHDF3 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID MLYCD GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID OBSL1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID SLC25A1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID HINT1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID CRYAA GeneID BioGRID Reconstituted Complex
    CAMKK2 BioGRID CAMK4 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID ATP2B4 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID FKBP5 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID CALM3 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID CALM2 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID CALM1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID INSYN2A GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID C6orf141 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID DUSP16 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID UBXN6 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID DNAI2 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID INF2 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID THAP11 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID FILIP1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID EEF1AKMT3 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID CDC37 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID ATG7 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID ZBTB33 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID PRKY GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID PRKAG1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID PRKAB1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID PRKAA2 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID NPAS1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID MYL4 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID IREB2 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID SFN GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID GCHFR GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID MAPK14 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID ALOX5 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID DNAJC7 GeneID BioGRID Proximity Label-MS
    CAMKK2 BioGRID PARK7 GeneID BioGRID Affinity Capture-Western; Co-localization; Reconstituted Complex
    CAMKK2 BioGRID PRKAA1 GeneID BioGRID Affinity Capture-Western
    CAMKK2 BioGRID VIM GeneID BioGRID Proximity Label-MS
    CAMKK2 BioGRID DYRK1A GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID TRIM25 GeneID BioGRID Affinity Capture-RNA
    CAMKK2 BioGRID APP GeneID BioGRID Reconstituted Complex
    CAMKK2 BioGRID HSP90AA1 GeneID BioGRID Affinity Capture-Luminescence
    CAMKK2 BioGRID NEDD4 GeneID BioGRID Reconstituted Complex
    CAMKK2 BioGRID CEP63 GeneID BioGRID Two-hybrid
    CAMKK2 BioGRID ESYT2 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID FANCI GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID ATG4B GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID XPOT GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID GCN1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID IQGAP2 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID SMC3 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID SLC25A11 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID SMC1A GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID PRKDC GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID IRAK1 GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID FLNC GeneID BioGRID Affinity Capture-MS
    CAMKK2 BioGRID FLNA GeneID BioGRID Affinity Capture-MS
    CAMKK2 Protein CAMK4 GeneID HPRD None
    CAMKK2 Protein CAMK1 GeneID HPRD None
    CAMKK2 Protein CALM1 GeneID HPRD None
    CAMKK2 BioGRID CAMK1 GeneID BioGRID Biochemical Activity
    CAMKK2 BioGRID PRKACA GeneID BioGRID Biochemical Activity
    CAMKK2 BioGRID SGK1 GeneID BioGRID Affinity Capture-Western
    StringDB
    A B experiments database textmining combined score hadb nhadb
    CAMKK2 GRIK5 0 0 112 164 1 1
    CAMKK2 GRIA1 0 0 241 321 1 1
    CAMKK2 ABR 0 0 46 172 1 1
    CAMKK2 FANCI 129 0 0 222 1 1
    CAMKK2 TSSK2 0 0 0 302 1 1
    CAMKK2 HELZ2 0 0 0 257 1 1
    CAMKK2 TBX1 0 0 0 160 1 1
    CAMKK2 IDE 0 0 103 280 1 1
    CAMKK2 PTK2B 0 0 254 185 1 1
    CAMKK2 CAT 0 0 167 167 1 1
    CAMKK2 P2RY6 0 0 181 182 1 1
    CAMKK2 ATP2A2 0 0 186 221 1 1
    CAMKK2 UAP1 0 0 116 212 1 1
    CAMKK2 LDLR 0 0 60 206 1 1
    CAMKK2 DCLK2 0 0 0 161 1 1
    CAMKK2 PPP2R5E 0 0 0 195 1 1
    CAMKK2 BCL2 0 0 431 431 1 2
    CAMKK2 PHLPP2 0 0 113 251 1 1
    CAMKK2 CNTN4 0 0 86 152 1 1
    CAMKK2 GPR113 0 0 112 167 1 1
    CAMKK2 RNASEL 0 0 0 171 1 1
    CAMKK2 HINFP 0 0 114 235 1 1
    CAMKK2 AHCTF1 0 0 55 150 1 1
    CAMKK2 RHEB 0 0 358 398 1 2
    CAMKK2 DDIT4 0 0 358 358 1 1
    CAMKK2 MTHFR 0 0 0 229 1 1
    CAMKK2 STIM1 0 0 270 346 1 2
    CAMKK2 HK3 0 0 0 153 1 1
    CAMKK2 MYL2 0 0 45 174 1 1
    CAMKK2 ATP2B2 0 0 74 206 1 1
    CAMKK2 NOS3 0 0 402 509 1 1
    CAMKK2 PPM1K 0 0 0 206 1 1
    CAMKK2 ACTA2 0 0 0 170 1 1
    CAMKK2 CCND1 0 0 185 185 1 1
    CAMKK2 ELMOD1 0 0 0 208 1 1
    CAMKK2 CACNA1B 0 0 113 175 1 1
    CAMKK2 RBM41 0 0 141 228 1 1
    CAMKK2 PRKAA1 0 900 451 970 1 2
    CAMKK2 ARHGEF7 0 650 410 784 1 1
    CAMKK2 LRGUK 0 0 0 257 1 1
    CAMKK2 ETV6 0 0 0 197 1 1
    CAMKK2 PPP2CA 0 0 85 196 1 1
    CAMKK2 PRKDC 62 0 62 190 1 2
    CAMKK2 DAGLB 0 0 57 162 1 1
    CAMKK2 EIF4E 0 0 218 337 1 1
    CAMKK2 CDK1 0 0 183 233 1 1
    CAMKK2 CPLX1 0 0 63 359 1 1
    CAMKK2 RNF215 0 0 162 303 1 1
    CAMKK2 YWHAQ 0 0 124 530 1 1
    CAMKK2 RPS6KB1 0 0 454 224 1 2
    CAMKK2 PGC 0 0 123 163 1 1
    CAMKK2 IRS1 0 0 317 317 1 1
    CAMKK2 SGK1 270 0 471 414 1 1
    CAMKK2 HSPA9 0 0 67 288 1 1
    CAMKK2 KCNA1 0 0 276 311 1 1
    CAMKK2 NUP62 0 0 460 460 1 1
    CAMKK2 HMGCR 0 0 260 315 1 1
    CAMKK2 NTRK1 0 0 123 153 1 1
    CAMKK2 IPMK 0 0 112 257 1 1
    CAMKK2 PPP2R5C 0 0 49 201 1 1
    CAMKK2 ATF3 0 0 134 193 1 1
    CAMKK2 CDK5R2 0 0 74 163 1 1
    CAMKK2 RETN 0 0 134 157 1 1
    CAMKK2 PKM 128 0 113 199 1 1
    CAMKK2 ANKRD27 0 0 0 152 1 1
    CAMKK2 BTK 0 0 113 160 1 1
    CAMKK2 DCLRE1A 0 0 0 166 1 1
    CAMKK2 GRIA3 0 0 83 152 1 1
    CAMKK2 NEDD4L 0 0 118 164 1 1
    CAMKK2 UVRAG 0 0 158 179 1 2
    CAMKK2 WDFY3 0 0 74 157 1 2
    CAMKK2 IGF1 0 0 235 235 1 1
    CAMKK2 MAPK1 0 0 211 233 1 2
    CAMKK2 GCG 0 0 325 325 1 1
    CAMKK2 CDC7 0 0 0 157 1 1
    CAMKK2 POTEI 0 0 0 161 1 1
    CAMKK2 LAMTOR3 0 0 142 181 1 1
    CAMKK2 TMPRSS2 0 0 241 258 1 1
    CAMKK2 ATG4B 65 0 137 298 1 2
    CAMKK2 CAMKV 0 0 0 176 1 1
    CAMKK2 RPS6KA2 0 0 320 165 1 1
    CAMKK2 IQGAP2 268 0 0 291 1 1
    CAMKK2 CDK17 0 0 0 206 1 1
    CAMKK2 BCL2A1 0 0 207 207 1 1
    CAMKK2 PPEF2 0 0 0 158 1 1
    CAMKK2 RAB7A 0 0 134 199 1 2
    CAMKK2 SYN2 0 0 154 226 1 1
    CAMKK2 DAGLA 0 0 45 235 1 1
    CAMKK2 FNIP2 0 0 127 159 1 1
    CAMKK2 EEF2 0 0 310 392 1 1
    CAMKK2 LIN7A 0 0 75 171 1 1
    CAMKK2 OBSL1 480 0 0 481 1 1
    CAMKK2 MKRN3 0 0 0 216 1 1
    CAMKK2 TSSK1B 0 0 0 302 1 1
    CAMKK2 CDK3 0 0 0 194 1 1
    CAMKK2 GRM4 0 0 141 177 1 1
    CAMKK2 DMPK 0 0 84 192 1 1
    CAMKK2 MRPL15 0 0 0 189 1 1
    CAMKK2 CDC42BPB 0 0 67 180 1 1
    CAMKK2 EPHB6 0 0 0 159 1 1
    CAMKK2 TNF 0 0 241 240 1 1
    CAMKK2 UCP3 0 0 123 188 1 1
    CAMKK2 HIPK3 0 0 67 158 1 1
    CAMKK2 UNC13A 0 0 54 155 1 1
    CAMKK2 BDNF 0 0 341 341 1 2
    CAMKK2 MEF2C 0 0 120 165 1 1
    CAMKK2 SLC1A5 0 0 106 153 1 1
    CAMKK2 GFER 0 0 322 321 1 1
    CAMKK2 IKBKB 0 0 181 175 1 1
    CAMKK2 ATF6 0 0 150 200 1 2
    CAMKK2 NTRK2 0 0 232 213 1 1
    CAMKK2 RPLP2 0 0 0 189 1 1
    CAMKK2 ACACB 0 0 260 374 1 1
    CAMKK2 SLC36A1 0 0 329 349 1 1
    CAMKK2 PPP2R4 0 0 325 325 1 1
    CAMKK2 TWF2 0 0 0 222 1 1
    CAMKK2 GRIK1 0 0 95 221 1 1
    CAMKK2 KIAA1598 0 0 145 184 1 1
    CAMKK2 PPARG 0 0 294 305 1 1
    CAMKK2 CDC42BPA 0 0 66 180 1 1
    CAMKK2 PPP1R9B 0 0 81 183 1 1
    CAMKK2 AKT1 0 0 556 282 1 2
    CAMKK2 WEE2 0 0 0 373 1 1
    CAMKK2 CPT1A 0 0 181 207 1 1
    CAMKK2 INPP5D 0 0 0 158 1 1
    CAMKK2 SYT4 0 0 113 170 1 1
    CAMKK2 FOXA1 0 0 120 166 1 1
    CAMKK2 CDK18 0 0 66 233 1 1
    CAMKK2 CREM 0 0 106 254 1 1
    CAMKK2 SNX7 0 0 0 185 1 2
    CAMKK2 CDK15 0 0 0 204 1 1
    CAMKK2 SYNGAP1 0 0 113 204 1 1
    CAMKK2 DENR 0 0 113 313 1 1
    CAMKK2 PPM1E 0 0 235 367 1 1
    CAMKK2 TRIM2 0 0 97 586 1 1
    CAMKK2 FAM196A 257 0 0 256 1 1
    CAMKK2 NGF 0 0 136 150 1 1
    CAMKK2 NDOR1 0 0 0 156 1 1
    CAMKK2 FOXF2 0 0 0 171 1 1
    CAMKK2 SIRT4 0 0 143 198 1 1
    CAMKK2 ST6GALNAC2 0 0 0 213 1 1
    CAMKK2 CCK 0 0 124 195 1 1
    CAMKK2 PPP3CA 0 0 69 182 1 1
    CAMKK2 GSK3A 0 0 138 278 1 1
    CAMKK2 CEP63 272 0 0 272 1 1
    CAMKK2 NFATC4 0 0 108 159 1 1
    CAMKK2 SIAE 0 0 0 364 1 1
    CAMKK2 HMGA1 0 0 210 210 1 1
    CAMKK2 GPT 0 0 386 386 1 1
    CAMKK2 EIF4EBP1 0 0 324 323 1 1
    CAMKK2 KLKB1 0 0 184 244 1 1
    CAMKK2 CD93 0 0 398 398 1 1
    CAMKK2 ARHGAP27 0 0 0 196 1 1
    CAMKK2 TXNDC9 0 0 697 697 1 1
    CAMKK2 ATG3 0 0 162 193 1 2
    CAMKK2 TESC 0 0 90 247 1 1
    CAMKK2 UBE2C 0 0 134 152 1 1
    CAMKK2 ACLY 0 0 181 181 1 1
    CAMKK2 LRRC7 0 0 150 198 1 1
    CAMKK2 TEN1-CDK3 0 0 0 194 1 1
    CAMKK2 FOXO3 0 0 323 369 1 2
    CAMKK2 SLC2A4 0 0 505 668 1 1
    CAMKK2 OXT 0 0 155 161 1 1
    CAMKK2 YWHAB 0 0 90 416 1 1
    CAMKK2 TNFSF11 0 0 167 167 1 1
    CAMKK2 ACTG2 0 0 0 170 1 1
    CAMKK2 MCU 0 0 170 221 1 1
    CAMKK2 SLK 0 0 391 180 1 1
    CAMKK2 ATG4C 0 0 71 194 1 2
    CAMKK2 HSPA12A 0 0 0 166 1 1
    CAMKK2 CRTC1 0 0 134 166 1 1
    CAMKK2 CDC42 0 0 138 170 1 1
    CAMKK2 PKMYT1 0 0 0 335 1 1
    CAMKK2 SRC 0 0 271 221 1 1
    CAMKK2 DIS3 0 0 0 248 1 1
    CAMKK2 VDAC1 0 0 142 155 1 2
    CAMKK2 PPM1D 0 0 0 206 1 1
    CAMKK2 TSC2 0 0 470 614 1 2
    CAMKK2 CNBD2 0 0 0 246 1 1
    CAMKK2 HACE1 0 0 0 168 1 1
    CAMKK2 PLLP 0 0 0 209 1 1
    CAMKK2 IQSEC2 0 0 61 226 1 1
    CAMKK2 TIAM1 0 0 150 218 1 1
    CAMKK2 ZFYVE1 0 0 112 158 1 2
    CAMKK2 CAMK1G 0 0 142 275 1 1
    CAMKK2 ARHGAP32 0 0 212 218 1 1
    CAMKK2 ADIPOR2 0 0 537 555 1 1
    CAMKK2 LRRK1 0 0 0 153 1 1
    CAMKK2 HMOX1 0 0 157 175 1 2
    CAMKK2 MITF 0 0 92 373 1 1
    CAMKK2 RRAGA 0 0 325 336 1 2
    CAMKK2 EIF2S1 0 0 120 152 1 2
    CAMKK2 PRMT5 0 0 0 227 1 1
    CAMKK2 NKX3-1 0 0 282 368 1 1
    CAMKK2 RAC2 0 0 129 169 1 1
    CAMKK2 P2RX1 0 0 43 399 1 1
    CAMKK2 PACSIN1 0 0 124 194 1 1
    CAMKK2 TBC1D9 0 0 0 277 1 1
    CAMKK2 MBD4 0 0 0 189 1 1
    CAMKK2 EIF4B 0 0 310 356 1 1
    CAMKK2 LIMK1 0 0 249 241 1 1
    CAMKK2 EPHA5 0 0 117 151 1 1
    CAMKK2 SLC45A3 0 0 127 260 1 1
    CAMKK2 JADE1 0 0 0 427 1 1
    CAMKK2 CASP3 0 0 269 269 1 2
    CAMKK2 EGLN1 0 0 73 493 1 1
    CAMKK2 ATG4D 0 0 73 196 1 2
    CAMKK2 PANK3 0 0 76 187 1 1
    CAMKK2 MAPK1IP1L 0 0 122 241 1 1
    CAMKK2 TRIB3 0 0 81 322 1 1
    CAMKK2 ATG101 0 0 150 170 1 2
    CAMKK2 DLG3 0 0 139 192 1 1
    CAMKK2 PPME1 0 0 0 435 1 1
    CAMKK2 TMEM206 0 0 0 420 1 1
    CAMKK2 ENSG00000268643 0 0 0 300 1 1
    CAMKK2 GRM1 0 0 108 175 1 1
    CAMKK2 MAPK15 0 0 234 224 1 2
    CAMKK2 PTPN5 0 0 96 154 1 1
    CAMKK2 RASGRF1 0 0 134 216 1 1
    CAMKK2 ATG12 0 0 242 247 1 2
    CAMKK2 STK17B 0 0 0 154 1 1
    CAMKK2 NTF3 0 0 134 153 1 1
    CAMKK2 PFN1 0 0 0 169 1 1
    CAMKK2 TRPM3 0 0 171 171 1 1
    CAMKK2 PPP6C 0 0 114 329 1 1
    CAMKK2 KCNQ2 0 0 67 171 1 1
    CAMKK2 CALM2 0 800 0 892 1 1
    CAMKK2 SOCS2 0 0 67 151 1 1
    CAMKK2 FABP4 0 0 129 222 1 1
    CAMKK2 EPHA3 0 0 75 164 1 1
    CAMKK2 SFN 0 0 0 360 1 1
    CAMKK2 TBC1D1 0 0 391 404 1 1
    CAMKK2 ZNF366 0 0 0 184 1 1
    CAMKK2 RIMS3 0 0 95 181 1 1
    CAMKK2 GSK3B 0 0 181 272 1 2
    CAMKK2 SIK1 0 0 283 187 1 1
    CAMKK2 LAMTOR1 0 0 150 171 1 1
    CAMKK2 YWHAH 0 0 0 391 1 1
    CAMKK2 MAP3K10 0 0 95 197 1 1
    CAMKK2 CSF1 0 0 91 202 1 1
    CAMKK2 ATG16L1 0 0 150 171 1 2
    CAMKK2 CEBPB 0 0 145 151 1 1
    CAMKK2 MEF2A 0 0 135 170 1 1
    CAMKK2 FAM105A 0 0 106 196 1 1
    CAMKK2 RRAGC 0 0 326 325 1 1
    CAMKK2 SNCB 0 0 108 167 1 1
    CAMKK2 YWHAZ 0 0 113 439 1 1
    CAMKK2 FOS 0 0 183 235 1 1
    CAMKK2 GHSR 0 0 140 193 1 1
    CAMKK2 PRKAR1A 0 0 44 249 1 2
    CAMKK2 GAS7 0 0 0 174 1 1
    CAMKK2 JADE3 0 0 0 286 1 1
    CAMKK2 CAPSL 0 0 0 186 1 1
    CAMKK2 FOXO1 0 0 260 310 1 2
    CAMKK2 KRAS 0 0 150 204 1 1
    CAMKK2 TSSK4 0 0 0 310 1 1
    CAMKK2 HSPA5 0 0 164 187 1 2
    CAMKK2 PDYN 0 0 108 163 1 1
    CAMKK2 NRAS 0 0 73 158 1 1
    CAMKK2 SLC35B2 0 0 0 261 1 1
    CAMKK2 SNRPB 0 0 0 187 1 1
    CAMKK2 CAMK4 213 900 731 949 1 1
    CAMKK2 MLST8 0 0 350 404 1 2
    CAMKK2 SNX2 0 0 0 185 1 1
    CAMKK2 PIM3 0 0 170 342 1 1
    CAMKK2 MAPK11 0 0 105 207 1 1
    CAMKK2 DDT 0 0 260 260 1 1
    CAMKK2 PPM1A 0 0 140 227 1 1
    CAMKK2 PICK1 0 0 157 156 1 1
    CAMKK2 CHAF1A 0 0 51 309 1 1
    CAMKK2 GRIN2B 0 0 184 195 1 1
    CAMKK2 LRRK2 0 0 265 296 1 2
    CAMKK2 CAB39L 0 0 155 173 1 1
    CAMKK2 CAMK2B 0 900 235 910 1 1
    CAMKK2 NUAK2 0 0 368 184 1 1
    CAMKK2 MAPT 0 0 242 260 1 2
    CAMKK2 BECN1 0 0 384 400 1 2
    CAMKK2 EIF4EBP2 0 0 321 321 1 1
    CAMKK2 SNX4 0 0 0 185 1 1
    CAMKK2 WEE1 0 0 181 465 1 1
    CAMKK2 EEF2K 0 0 164 252 1 2
    CAMKK2 GYS1 0 0 124 159 1 1
    CAMKK2 STXBP1 0 0 117 225 1 1
    CAMKK2 CDK5R1 0 0 107 338 1 1
    CAMKK2 STK17A 0 0 108 175 1 1
    CAMKK2 RRAGD 0 0 326 325 1 1
    CAMKK2 AMACR 0 0 166 165 1 1
    CAMKK2 CDC25A 0 0 0 473 1 1
    CAMKK2 PAK4 0 0 103 153 1 1
    CAMKK2 LARP1B 0 0 0 252 1 1
    CAMKK2 KSR1 0 0 123 165 1 1
    CAMKK2 ATG5 0 0 289 288 1 2
    CAMKK2 KLF11 0 0 66 164 1 1
    CAMKK2 PPP5D1 0 0 0 158 1 1
    CAMKK2 SYP 0 0 142 180 1 1
    CAMKK2 GRIN1 0 0 67 283 1 1
    CAMKK2 ZNF35 0 0 90 219 1 1
    CAMKK2 MYO7A 0 0 62 164 1 1
    CAMKK2 ILKAP 0 0 90 247 1 1
    CAMKK2 CAMK1 463 900 765 962 1 1
    CAMKK2 HIPK2 0 0 67 158 1 1
    CAMKK2 GIT1 0 650 260 752 1 1
    CAMKK2 MYBL2 0 0 359 359 1 1
    CAMKK2 PRKAG2 0 900 393 974 1 1
    CAMKK2 NRD1 0 0 0 190 1 1
    CAMKK2 NUAK1 0 0 290 209 1 1
    CAMKK2 ENSG00000100926 0 0 137 191 1 1
    CAMKK2 MBNL1 0 0 67 210 1 1
    CAMKK2 SIRT1 0 0 463 490 1 2
    CAMKK2 LARP4 0 0 74 275 1 1
    CAMKK2 EOMES 0 0 293 314 1 1
    CAMKK2 AVPR2 0 0 62 157 1 1
    CAMKK2 HOMER1 0 0 167 167 1 1
    CAMKK2 BACE1 0 0 127 157 1 1
    CAMKK2 PDK4 0 0 107 282 1 1
    CAMKK2 LYN 0 0 99 154 1 1
    CAMKK2 LIMCH1 0 0 73 163 1 1
    CAMKK2 PPP1CA 0 0 0 303 1 1
    CAMKK2 PIM2 0 0 150 332 1 2
    CAMKK2 MAPK6 0 0 52 161 1 1
    CAMKK2 ESR1 0 0 157 171 1 1
    CAMKK2 CLK2 0 0 306 388 1 1
    CAMKK2 CDC25B 0 0 0 473 1 1
    CAMKK2 ULK1 0 0 454 259 1 2
    CAMKK2 CAMK2A 0 0 214 249 1 2
    CAMKK2 MYLK3 0 0 96 194 1 1
    CAMKK2 PAQR3 0 0 49 163 1 2
    CAMKK2 PIP4K2C 0 0 150 201 1 1
    CAMKK2 MED31 0 0 74 326 1 1
    CAMKK2 PSKH1 0 0 0 169 1 1
    CAMKK2 DYRK1A 270 0 323 566 1 1
    CAMKK2 NAV3 0 0 0 234 1 1
    CAMKK2 ATP2B1 0 0 0 176 1 1
    CAMKK2 CYB5D2 0 0 0 345 1 1
    CAMKK2 MAP1LC3B 0 0 322 322 1 2
    CAMKK2 TAC1 0 0 45 215 1 1
    CAMKK2 MARCKS 0 0 161 180 1 1
    CAMKK2 EGLN2 0 0 46 643 1 1
    CAMKK2 ATG7 0 0 282 282 1 2
    CAMKK2 PAPLN 0 0 0 187 1 1
    CAMKK2 SNX30 0 0 0 185 1 1
    CAMKK2 GLIS1 0 0 0 152 1 1
    CAMKK2 DYRK1B 0 0 125 180 1 1
    CAMKK2 DLG4 0 0 236 318 1 1
    CAMKK2 ACTG1 0 0 58 176 1 1
    CAMKK2 PFN2 0 0 0 169 1 1
    CAMKK2 CPT1C 0 0 193 204 1 1
    CAMKK2 TBC1D8 0 0 0 151 1 1
    CAMKK2 NAMPT 0 0 137 166 1 1
    CAMKK2 DAPK2 0 0 218 194 1 2
    CAMKK2 AXIN1 0 0 182 181 1 1
    CAMKK2 ATM 0 0 203 203 1 1
    CAMKK2 C6orf211 0 0 0 187 1 1
    CAMKK2 MTRR 0 0 0 179 1 1
    CAMKK2 PRKAG3 0 900 245 961 1 1
    CAMKK2 SIK3 0 0 210 202 1 1
    CAMKK2 ENDOD1 0 0 93 187 1 1
    CAMKK2 DNAJB13 0 0 0 206 1 1
    CAMKK2 NRGN 0 0 142 218 1 1
    CAMKK2 AGRP 0 0 328 328 1 1
    CAMKK2 GABRA6 0 0 70 217 1 1
    CAMKK2 NPTX1 0 0 113 215 1 1
    CAMKK2 FOXN4 0 0 51 156 1 1
    CAMKK2 ZC3H12A 0 0 0 159 1 1
    CAMKK2 RIMS1 0 0 136 179 1 1
    CAMKK2 PPP1R9A 0 0 60 205 1 1
    CAMKK2 AMBRA1 0 0 180 190 1 2
    CAMKK2 NFKBIA 0 0 138 155 1 1
    CAMKK2 LEP 0 0 394 394 1 1
    CAMKK2 SYK 0 0 123 153 1 1
    CAMKK2 EIF4E1B 0 0 0 188 1 1
    CAMKK2 STK33 0 0 140 199 1 1
    CAMKK2 EIF4EBP3 0 0 330 330 1 1
    CAMKK2 CFL1 0 0 134 170 1 1
    CAMKK2 MAPK14 336 0 170 445 1 1
    CAMKK2 CAPN7 0 0 71 169 1 1
    CAMKK2 SLC36A4 0 0 350 349 1 1
    CAMKK2 TSSK6 0 0 0 300 1 1
    CAMKK2 SREBF1 0 0 341 341 1 2
    CAMKK2 UCP1 0 0 126 186 1 1
    CAMKK2 VEGFA 0 0 184 183 1 1
    CAMKK2 ACSL4 0 0 74 168 1 1
    CAMKK2 STK40 0 0 0 314 1 1
    CAMKK2 MAPK7 0 0 181 210 1 1
    CAMKK2 SLC2A14 0 0 203 248 1 1
    CAMKK2 RIMS2 0 0 143 200 1 1
    CAMKK2 PTEN 0 0 275 318 1 2
    CAMKK2 DNM1L 0 0 194 202 1 2
    CAMKK2 PANK2 0 0 52 193 1 1
    CAMKK2 RRAGB 0 0 328 339 1 2
    CAMKK2 NTRK3 0 0 138 158 1 1
    CAMKK2 C6orf141 257 0 0 256 1 1
    CAMKK2 PRKAA2 195 900 605 975 1 2
    CAMKK2 NFATC1 0 0 204 204 1 1
    CAMKK2 FMO3 0 0 0 150 1 1
    CAMKK2 CDK14 0 0 0 205 1 1
    CAMKK2 ARMC8 0 0 91 206 1 1
    CAMKK2 CPT2 0 0 101 157 1 1
    CAMKK2 ETNK1 0 0 67 164 1 1
    CAMKK2 RASGRP3 0 0 46 150 1 1
    CAMKK2 WNK1 0 0 107 183 1 1
    CAMKK2 PPP1R12C 0 0 108 258 1 1
    CAMKK2 STAT3 0 0 193 193 1 2
    CAMKK2 ERN1 0 0 161 180 1 2
    CAMKK2 PRKAR2A 0 0 0 246 1 1
    CAMKK2 MCOLN1 0 0 161 161 1 1
    CAMKK2 INPP5E 0 0 0 150 1 1
    CAMKK2 BRF1 0 0 0 161 1 1
    CAMKK2 PIN1 0 0 0 288 1 1
    CAMKK2 FMO6P 0 0 0 150 1 1
    CAMKK2 MELK 0 0 170 345 1 1
    CAMKK2 CALM3 128 0 232 637 1 1
    CAMKK2 VGF 0 0 108 245 1 1
    CAMKK2 ATP2B4 0 0 122 386 1 1
    CAMKK2 NPRL2 0 0 49 177 1 1
    CAMKK2 GHRL 0 0 405 405 1 1
    CAMKK2 JAK2 0 0 108 170 1 1
    CAMKK2 CCNI 0 0 0 164 1 1
    CAMKK2 GUK1 0 0 0 208 1 1
    CAMKK2 PPP2R5D 0 0 0 195 1 1
    CAMKK2 NOL6 0 0 82 162 1 1
    CAMKK2 DDIT3 0 0 120 208 1 2
    CAMKK2 MAP3K7 0 0 391 259 1 1
    CAMKK2 CDC42BPG 0 0 106 193 1 1
    CAMKK2 VPS4B 0 0 54 150 1 1
    CAMKK2 BRSK1 0 0 469 522 1 1
    CAMKK2 RAF1 0 0 113 160 1 2
    CAMKK2 PGBD4 0 0 170 192 1 1
    CAMKK2 SLC2A2 0 0 194 240 1 1
    CAMKK2 TXK 0 0 123 164 1 1
    CAMKK2 IRAK1 129 0 73 239 1 1
    CAMKK2 P2RX4 0 0 248 323 1 1
    CAMKK2 RREB1 0 0 54 332 1 1
    CAMKK2 HK2 0 0 166 405 1 1
    CAMKK2 PFKFB2 0 0 212 221 1 1
    CAMKK2 SLC2A1 0 0 323 361 1 1
    CAMKK2 LAMP1 0 0 95 166 1 2
    CAMKK2 PPP1R1C 0 0 0 187 1 1
    CAMKK2 FFAR1 0 0 180 179 1 1
    CAMKK2 MYL10 0 0 0 171 1 1
    CAMKK2 PPP1CC 0 0 55 313 1 1
    CAMKK2 PSTPIP1 0 0 0 154 1 1
    CAMKK2 CDK4 0 0 113 218 1 1
    CAMKK2 ZSCAN31 0 0 112 152 1 1
    CAMKK2 STEAP4 0 0 0 217 1 1
    CAMKK2 SLC12A5 0 0 129 180 1 1
    CAMKK2 TP53 0 0 335 335 1 2
    CAMKK2 RASGRP1 0 0 0 193 1 1
    CAMKK2 ZBTB11 0 0 108 234 1 1
    CAMKK2 CREBZF 0 0 146 178 1 1
    CAMKK2 NPY 0 0 290 290 1 1
    CAMKK2 STK11 0 800 828 886 1 2
    CAMKK2 POR 0 0 0 179 1 1
    CAMKK2 CHN2 0 0 0 153 1 1
    CAMKK2 MAP2K1 0 0 203 162 1 1
    CAMKK2 SHISA7 0 0 113 330 1 1
    CAMKK2 ODC1 0 0 72 214 1 1
    CAMKK2 MFF 0 0 162 161 1 1
    CAMKK2 LARP1 0 0 0 252 1 1
    CAMKK2 CARNS1 0 0 0 157 1 1
    CAMKK2 RB1CC1 0 0 235 235 1 2
    CAMKK2 MECP2 0 0 135 163 1 1
    CAMKK2 CAB39 0 0 563 572 1 1
    CAMKK2 GLRA2 0 0 150 280 1 1
    CAMKK2 MYL9 0 0 67 155 1 1
    CAMKK2 PAK7 0 0 62 151 1 1
    CAMKK2 SPEG 0 0 0 160 1 1
    CAMKK2 EIF3G 0 0 0 208 1 1
    CAMKK2 ENSG00000272772 0 0 0 201 1 1
    CAMKK2 HIPK4 0 0 108 270 1 1
    CAMKK2 FHL2 0 0 73 163 1 1
    CAMKK2 RPS25 0 0 0 186 1 1
    CAMKK2 ACTA1 0 0 66 192 1 1
    CAMKK2 SLC2A3 0 0 180 227 1 1
    CAMKK2 PPP3CC 0 0 0 158 1 1
    CAMKK2 FLNA 268 0 0 296 1 1
    CAMKK2 RIMS4 0 0 111 189 1 1
    CAMKK2 ELMOD3 0 0 0 157 1 1
    CAMKK2 HDAC5 0 0 213 239 1 1
    CAMKK2 PBK 0 0 57 161 1 1
    CAMKK2 ACACA 0 0 320 424 1 1
    CAMKK2 TAB1 0 0 113 289 1 1
    CAMKK2 PIM1 0 0 46 311 1 1
    CAMKK2 RICTOR 0 0 306 306 1 2
    CAMKK2 SOAT2 0 0 63 157 1 1
    CAMKK2 APPL1 0 0 122 177 1 1
    CAMKK2 G6PC 0 0 260 260 1 1
    CAMKK2 EFTUD2 0 0 0 213 1 1
    CAMKK2 MYLK4 0 0 0 171 1 1
    CAMKK2 EGLN3 0 0 0 196 1 1
    CAMKK2 DVL1 0 0 108 234 1 1
    CAMKK2 GNAQ 0 0 134 154 1 1
    CAMKK2 PPP3CB 0 0 60 174 1 1
    CAMKK2 OBSCN 0 0 92 176 1 1
    CAMKK2 IGF1R 0 0 233 197 1 1
    CAMKK2 KALRN 0 0 203 203 1 1
    CAMKK2 PPARGC1A 0 0 502 502 1 1
    CAMKK2 TM9SF1 0 0 135 154 1 2
    CAMKK2 ELMOD2 0 0 0 345 1 1
    CAMKK2 MYC 0 0 447 447 1 2
    CAMKK2 PFN4 0 0 0 169 1 1
    CAMKK2 PPP5C 0 0 0 158 1 1
    CAMKK2 CCNH 0 0 84 154 1 1
    CAMKK2 GABARAPL2 0 0 171 171 1 2
    CAMKK2 FKBP8 0 0 326 342 1 1
    CAMKK2 BRSK2 0 0 370 505 1 1
    CAMKK2 POTEE 0 0 0 161 1 1
    CAMKK2 TSSK3 0 0 0 298 1 1
    CAMKK2 NOS2 0 0 52 269 1 1
    CAMKK2 SPDEF 0 0 113 174 1 1
    CAMKK2 B3GAT1 0 0 0 167 1 1
    CAMKK2 KSR2 0 0 195 282 1 1
    CAMKK2 TLR4 0 0 163 176 1 1
    CAMKK2 SLC25A11 129 0 0 222 1 1
    CAMKK2 GAPDH 0 0 284 284 1 2
    CAMKK2 RAB18 0 0 0 286 1 1
    CAMKK2 ATG14 0 0 202 202 1 2
    CAMKK2 STRADA 0 0 595 312 1 1
    CAMKK2 TUBB4A 0 0 67 163 1 1
    CAMKK2 NPR1 0 0 142 180 1 1
    CAMKK2 PIK3R4 0 0 243 337 1 2
    CAMKK2 PHLPP1 0 0 96 221 1 1
    CAMKK2 CAPN15 0 0 107 302 1 1
    CAMKK2 NPTN 0 0 118 254 1 1
    CAMKK2 NABP1 0 0 74 172 1 1
    CAMKK2 JADE2 0 0 0 227 1 1
    CAMKK2 ITPR2 0 0 123 156 1 1
    CAMKK2 SIRT2 0 0 151 194 1 2
    CAMKK2 NCS1 0 0 0 156 1 1
    CAMKK2 AGAP2 0 0 0 164 1 1
    CAMKK2 PLK1 0 0 246 175 1 1
    CAMKK2 FLNC 272 0 44 290 1 1
    CAMKK2 GRIA4 0 0 87 151 1 1
    CAMKK2 PIANP 0 0 95 180 1 1
    CAMKK2 GRIA2 0 0 242 319 1 1
    CAMKK2 KLK2 0 0 202 202 1 1
    CAMKK2 ANXA5 0 0 167 167 1 1
    CAMKK2 RAPGEF4 0 0 134 153 1 1
    CAMKK2 LRRC4B 0 0 0 178 1 1
    CAMKK2 FOXM1 0 0 66 166 1 1
    CAMKK2 TRPC1 0 0 97 173 1 1
    CAMKK2 BTF3L4 0 0 123 184 1 1
    CAMKK2 RAPGEF3 0 0 202 231 1 1
    CAMKK2 CREB1 0 0 504 612 1 1
    CAMKK2 SRM 0 0 0 303 1 1
    CAMKK2 PRKACA 270 0 123 371 1 1
    CAMKK2 ESRRA 0 0 291 302 1 1
    CAMKK2 CADPS2 0 0 117 163 1 1
    CAMKK2 PFKFB3 0 0 320 333 1 1
    CAMKK2 MAPK4 0 0 0 157 1 1
    CAMKK2 CREBBP 0 0 142 257 1 1
    CAMKK2 ARF1 0 0 43 184 1 1
    CAMKK2 RYR2 0 0 150 173 1 1
    CAMKK2 CROT 0 0 45 151 1 1
    CAMKK2 PLEK 0 0 182 181 1 1
    CAMKK2 KCNJ9 0 0 95 162 1 1
    CAMKK2 RPS6 0 0 170 200 1 1
    CAMKK2 PIK3C3 0 0 361 376 1 2
    CAMKK2 DPM2 0 0 0 237 1 1
    CAMKK2 PPP4C 0 0 0 158 1 1
    CAMKK2 UCP2 0 0 297 349 1 1
    CAMKK2 CHD1L 0 0 0 218 1 1
    CAMKK2 IL6 0 0 211 211 1 1
    CAMKK2 JPH4 0 0 81 305 1 1
    CAMKK2 EFHB 0 0 0 186 1 1
    CAMKK2 GPR1 0 0 101 157 1 1
    CAMKK2 MYO9B 0 0 0 178 1 1
    CAMKK2 TRIB2 0 0 0 310 1 1
    CAMKK2 GABRA1 0 0 67 158 1 1
    CAMKK2 SMARCAD1 0 0 0 200 1 1
    CAMKK2 MTOR 0 0 528 559 1 2
    CAMKK2 CALM1 271 0 218 794 1 1
    CAMKK2 POTEF 0 0 55 173 1 1
    CAMKK2 MYLK2 0 0 270 236 1 1
    CAMKK2 LYPLA1 0 0 120 193 1 1
    CAMKK2 PRICKLE1 0 0 60 151 1 1
    CAMKK2 MARK4 0 0 294 234 1 1
    CAMKK2 CPEB3 0 0 57 236 1 1
    CAMKK2 MAST1 0 0 0 167 1 1
    CAMKK2 MYL5 0 0 0 215 1 1
    CAMKK2 NOTCH1 0 0 113 174 1 1
    CAMKK2 CSNK1G1 0 0 103 184 1 1
    CAMKK2 PASK 0 0 0 398 1 1
    CAMKK2 ACSL3 0 0 103 392 1 1
    CAMKK2 DCLK3 0 0 0 155 1 1
    CAMKK2 PRKAG1 272 900 334 978 1 1
    CAMKK2 CACNA1C 0 0 203 234 1 1
    CAMKK2 PRKAR2B 0 0 0 246 1 1
    CAMKK2 CDK2 0 0 181 226 1 1
    CAMKK2 HRAS 0 0 184 226 1 1
    CAMKK2 MAP1LC3A 0 0 194 214 1 2
    CAMKK2 CTNNB1 0 0 195 195 1 1
    CAMKK2 WDR26 0 0 81 211 1 1
    CAMKK2 LMTK2 0 0 120 208 1 1
    CAMKK2 EGR1 0 0 134 186 1 1
    CAMKK2 DCAF6 0 0 60 168 1 1
    CAMKK2 APP 0 0 234 240 1 1
    CAMKK2 MAPK13 0 0 55 162 1 1
    CAMKK2 SLC1A7 0 0 291 328 1 1
    CAMKK2 KLK3 0 0 293 293 1 1
    CAMKK2 GCK 0 0 141 241 1 1
    CAMKK2 SIRT5 0 0 150 185 1 1
    CAMKK2 HIF1A 0 0 242 241 1 2
    CAMKK2 IL1B 0 0 204 204 1 1
    CAMKK2 CMPK1 0 0 64 156 1 1
    CAMKK2 CHRNA6 0 0 0 245 1 1
    CAMKK2 FBXL12 0 0 163 202 1 1
    CAMKK2 DLG2 0 0 155 219 1 1
    CAMKK2 DYRK2 0 0 125 178 1 1
    CAMKK2 RAB29 0 0 95 157 1 1
    CAMKK2 DNAJA4 0 0 60 152 1 1
    CAMKK2 PSEN1 0 0 124 154 1 2
    CAMKK2 CHRM1 0 0 86 180 1 1
    CAMKK2 FXYD1 0 0 0 184 1 1
    CAMKK2 MYO9A 0 0 66 199 1 1
    CAMKK2 NENF 0 0 0 225 1 1
    CAMKK2 HSP90AA1 129 0 146 224 1 2
    CAMKK2 TFEB 0 0 294 317 1 2
    CAMKK2 SQSTM1 0 0 242 241 1 2
    CAMKK2 GABRD 0 0 95 253 1 1
    CAMKK2 ABCG1 0 0 107 191 1 1
    CAMKK2 SYT6 0 0 113 206 1 1
    CAMKK2 SIRT3 0 0 202 242 1 2
    CAMKK2 MAPK3 0 0 286 256 1 2
    CAMKK2 GLP1R 0 0 161 161 1 1
    CAMKK2 TES 0 0 0 276 1 1
    CAMKK2 CAMK2N2 0 0 422 434 1 1
    CAMKK2 SGTB 0 0 108 182 1 1
    CAMKK2 CIT 0 0 75 184 1 1
    CAMKK2 ZNF185 0 0 0 178 1 1
    CAMKK2 ACTB 0 0 335 418 1 1
    CAMKK2 INS 0 0 504 504 1 1
    CAMKK2 ATG13 0 0 260 260 1 2
    CAMKK2 SYN1 0 0 233 276 1 1
    CAMKK2 STX1A 0 0 151 192 1 1
    CAMKK2 BTBD3 0 0 108 277 1 1
    CAMKK2 RHOA 0 0 181 212 1 1
    CAMKK2 C2CD3 0 0 0 371 1 1
    CAMKK2 AR 270 0 404 563 1 1
    CAMKK2 CRTC2 0 0 343 343 1 1
    CAMKK2 SNX8 0 0 0 185 1 1
    CAMKK2 INSR 0 0 172 173 1 1
    CAMKK2 GABARAPL1 0 0 180 180 1 2
    CAMKK2 ABCG4 0 0 0 158 1 1
    CAMKK2 SLC25A14 0 0 0 171 1 1
    CAMKK2 TUBGCP4 0 0 152 151 1 1
    CAMKK2 SIRT7 0 0 136 169 1 1
    CAMKK2 AP3M2 0 0 0 151 1 1
    CAMKK2 HUNK 0 0 0 315 1 1
    CAMKK2 NIM1K 0 0 0 310 1 1
    CAMKK2 SMC1A 245 0 0 244 1 1
    CAMKK2 TRPC5 0 0 153 203 1 1
    CAMKK2 TBC1D4 0 0 391 404 1 1
    CAMKK2 EIF3M 0 0 0 213 1 1
    CAMKK2 CDC25C 0 0 53 479 1 1
    CAMKK2 SHISA9 0 0 82 280 1 1
    CAMKK2 ATP2B3 0 0 0 184 1 1
    CAMKK2 FYN 0 0 161 179 1 1
    CAMKK2 RTN1 0 0 55 152 1 1
    CAMKK2 HIVEP3 0 0 54 159 1 1
    CAMKK2 PP2D1 0 0 0 206 1 1
    CAMKK2 LCK 0 0 95 153 1 1
    CAMKK2 YWHAE 0 0 45 367 1 1
    CAMKK2 BPIFA3 0 0 124 196 1 1
    CAMKK2 LAMP2 0 0 143 208 1 2
    CAMKK2 TRIM3 0 0 0 271 1 1
    CAMKK2 TFAM 0 0 195 229 1 1
    CAMKK2 PPM1F 0 0 66 227 1 1
    CAMKK2 RIPK2 0 0 122 153 1 1
    CAMKK2 SEPT5 0 0 0 169 1 1
    CAMKK2 PNCK 0 0 118 254 1 1
    CAMKK2 ESYT2 128 0 0 242 1 1
    CAMKK2 PRKACB 0 0 84 155 1 1
    CAMKK2 CAMK1D 0 0 640 358 1 1
    CAMKK2 IRS2 0 0 155 154 1 1
    CAMKK2 SEPT4 0 0 0 168 1 1
    CAMKK2 GALK2 0 0 92 181 1 1
    CAMKK2 CAV1 0 0 202 213 1 1
    CAMKK2 GABRG1 0 0 123 253 1 1
    CAMKK2 SIK2 0 0 330 222 1 1
    CAMKK2 SLC8A1 0 0 107 326 1 1
    CAMKK2 ULK2 0 0 235 167 1 2
    CAMKK2 PLK5 0 0 0 187 1 1
    CAMKK2 VRK2 0 0 96 152 1 1
    CAMKK2 ENSG00000268434 0 0 0 280 1 1
    CAMKK2 NPC2 0 0 90 152 1 1
    CAMKK2 SNCA 0 0 134 152 1 2
    CAMKK2 AKT1S1 0 0 230 229 1 1
    CAMKK2 DEDD 0 0 112 180 1 1
    CAMKK2 NOS1 0 0 113 273 1 1
    CAMKK2 JUN 0 0 242 241 1 1
    CAMKK2 DIS3L 0 0 0 248 1 1
    CAMKK2 ITPR3 0 0 339 366 1 1
    CAMKK2 GTF2H3 0 0 65 158 1 1
    CAMKK2 DAPK1 0 0 247 222 1 2
    CAMKK2 TTC8 0 0 124 356 1 1
    CAMKK2 SNX1 0 0 0 185 1 1
    CAMKK2 TJP3 0 0 56 151 1 1
    CAMKK2 TSC1 0 0 291 290 1 2
    CAMKK2 KIF11 0 0 0 167 1 1
    CAMKK2 DIS3L2 0 0 0 262 1 1
    CAMKK2 PLEKHH1 0 0 0 196 1 1
    CAMKK2 NRF1 0 0 155 154 1 1
    CAMKK2 SLC8A2 0 0 0 172 1 1
    CAMKK2 ENSG00000173366 0 0 0 215 1 1
    CAMKK2 BRD3 0 0 0 242 1 1
    CAMKK2 LUC7L 0 0 75 170 1 1
    CAMKK2 TRIO 0 0 0 157 1 1
    CAMKK2 MAPK12 0 0 134 187 1 1
    CAMKK2 RPTOR 0 0 469 473 1 2
    CAMKK2 ZNF77 0 0 235 269 1 1
    CAMKK2 CAPS2 0 0 0 186 1 1
    CAMKK2 PPARA 0 0 308 319 1 1
    CAMKK2 TRIB1 0 0 74 317 1 1
    CAMKK2 LPL 0 0 122 179 1 1
    CAMKK2 TBC1D9B 0 0 0 170 1 1
    CAMKK2 RPUSD4 0 0 96 175 1 1
    CAMKK2 C1QTNF2 0 0 432 432 1 1
    CAMKK2 PGRMC1 0 0 0 157 1 1
    CAMKK2 POTEJ 0 0 0 161 1 1
    CAMKK2 SNRPN 0 0 0 187 1 1
    CAMKK2 DYRK3 0 0 145 186 1 1
    CAMKK2 EPS15L1 0 0 67 154 1 1
    CAMKK2 EGF 0 0 134 161 1 1
    CAMKK2 PRKAB2 0 900 425 970 1 1
    CAMKK2 GAK 0 0 171 151 1 1
    CAMKK2 TIAM2 0 0 129 179 1 1
    CAMKK2 FASN 0 0 193 278 1 1
    CAMKK2 ATG4A 0 0 47 185 1 2
    CAMKK2 ITPR1 0 0 334 378 1 2
    CAMKK2 SLC1A2 0 0 96 169 1 1
    CAMKK2 HK1 0 0 0 153 1 1
    CAMKK2 POMC 0 0 194 194 1 1
    CAMKK2 RPS6KA3 0 0 358 162 1 1
    CAMKK2 CAMKK1 0 900 748 909 1 1
    CAMKK2 DGKZ 0 0 75 190 1 1
    CAMKK2 PLK2 0 0 205 161 1 1
    CAMKK2 PSKH2 0 0 0 151 1 1
    CAMKK2 UHMK1 0 0 0 158 1 1
    CAMKK2 GCN1L1 183 0 0 183 1 1
    CAMKK2 PPM1L 0 0 0 206 1 1
    CAMKK2 PDP1 0 0 150 236 1 1
    CAMKK2 SERPING1 0 0 0 186 1 1
    CAMKK2 PRKAR1B 0 0 81 304 1 1
    CAMKK2 LAMP5 0 0 96 178 1 1
    CAMKK2 ADIPOQ 0 0 418 418 1 1
    CAMKK2 NAA25 0 0 74 157 1 1
    CAMKK2 MAPK8 0 0 242 152 1 2
    CAMKK2 SKP2 0 0 101 162 1 1
    CAMKK2 MAP7D2 0 0 112 205 1 1
    CAMKK2 PAQR6 0 0 0 176 1 1
    CAMKK2 PRKAB1 0 900 519 975 1 2
    CAMKK2 P2RX7 0 0 188 206 1 1
    CAMKK2 PDSS1 0 0 81 393 1 1
    CAMKK2 PPP2R5B 0 0 0 224 1 1
    CAMKK2 PPP2CB 0 0 0 158 1 1
    CAMKK2 CPT1B 0 0 123 207 1 1
    CAMKK2 KCTD20 0 0 134 151 1 1
    CAMKK2 DAPK3 0 0 261 215 1 2
    CAMKK2 CALML4 0 800 0 813 1 1
    CAMKK2 STIM2 0 0 433 433 1 1
    CAMKK2 GRM3 0 0 117 155 1 1
    CAMKK2 IER5L 0 0 108 198 1 1
    CAMKK2 MTR 0 0 0 217 1 1
    CAMKK2 ATP2A1 0 0 170 205 1 1
    CAMKK2 MAGI3 0 0 0 239 1 1
    CAMKK2 CALML6 0 800 113 827 1 1
    CAMKK2 PAX6 0 0 0 157 1 1
    CAMKK2 ROCK2 0 0 137 201 1 1
    CAMKK2 PPP1CB 0 0 60 317 1 1
    CAMKK2 ALK 0 0 108 194 1 1
    CAMKK2 PLEKHH2 0 0 217 635 1 1
    CAMKK2 MAP3K11 0 0 134 156 1 1
    CAMKK2 FKBP5 0 0 251 285 1 1
    CAMKK2 PPP2R5A 0 0 0 195 1 1
    CAMKK2 CDK16 0 0 108 268 1 1
    CAMKK2 TWF1 0 0 0 222 1 1
    CAMKK2 MLXIPL 0 0 193 411 1 1
    CAMKK2 PRKCZ 0 0 202 208 1 1
    CAMKK2 RYR1 0 0 218 239 1 2
    CAMKK2 SCARA5 0 0 0 236 1 1
    CAMKK2 CALML3 0 800 0 813 1 1
    CAMKK2 ACTC1 0 0 0 170 1 1
    CAMKK2 CAPS 0 0 0 186 1 1
    CAMKK2 YWHAG 0 0 698 806 1 1
    CAMKK2 CDK6 0 0 74 208 1 1
    CAMKK2 CHRM3 0 0 170 190 1 1
    CAMKK2 SLC25A30 0 0 0 171 1 1
    CAMKK2 SMG5 0 0 49 200 1 1
    CAMKK2 SIRT6 0 0 150 183 1 1
    CAMKK2 ABCC4 0 0 91 298 1 1
    CAMKK2 ROCK1 0 0 118 194 1 1
    CAMKK2 PAPOLG 0 0 0 212 1 1
    CAMKK2 PPEF1 0 0 0 158 1 1
    CAMKK2 RNF123 0 0 0 336 1 1
    CAMKK2 ADIPOR1 0 0 608 623 1 1
    CAMKK2 PGRMC2 0 0 0 298 1 1
    CAMKK2 EP300 0 0 113 209 1 1
    CAMKK2 STK35 0 0 180 151 1 1
    CAMKK2 HKDC1 0 0 0 153 1 1
    CAMKK2 MSRB2 0 0 256 256 1 1
    CAMKK2 PVALB 0 0 82 176 1 1
    CAMKK2 CALML5 0 800 67 821 1 1
    CAMKK2 CAMK2N1 0 0 112 265 1 1
    CAMKK2 DCLK1 0 0 72 183 1 1
    CAMKK2 ALB 0 0 247 246 1 1
    CAMKK2 CDC23 0 0 50 320 1 1
    CAMKK2 GABRA4 0 0 0 173 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005524 Molecular Function ATP binding enables IEA
    GO:0005509 Molecular Function calcium ion binding enables IDA
    GO:0004683 Molecular Function calcium/calmodulin-dependent protein kinase activity enables IEA
    GO:0005516 Molecular Function calmodulin binding enables TAS
    GO:0106310 Molecular Function protein serine kinase activity enables IEA
    GO:0004674 Molecular Function protein serine/threonine kinase activity enables IBA
    GO:0004713 Molecular Function protein tyrosine kinase activity enables TAS
    GO:0061762 Biological Process CAMKK-AMPK signaling cascade involved_in IBA
    GO:0061762 Biological Process CAMKK-AMPK signaling cascade involved_in IMP
    GO:0000165 Biological Process MAPK cascade involved_in TAS
    GO:0019722 Biological Process calcium-mediated signaling involved_in TAS
    GO:0034614 Biological Process cellular response to reactive oxygen species involved_in TAS
    GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in TAS
    GO:1903599 Biological Process positive regulation of autophagy of mitochondrion involved_in IC
    GO:0001934 Biological Process positive regulation of protein phosphorylation involved_in IMP
    GO:0046777 Biological Process protein autophosphorylation involved_in IDA
    GO:0006468 Biological Process protein phosphorylation involved_in IDA
    GO:0045859 Biological Process regulation of protein kinase activity involved_in TAS
    GO:0005829 Cellular Component cytosol located_in IDA
    GO:0005829 Cellular Component cytosol located_in IMP
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0043005 Cellular Component neuron projection located_in IEA
    GO:0005654 Cellular Component nucleoplasm located_in TAS
    Pathways
    Name DB ID
    Opioid Signalling Reactome R-HSA-111885
    CaMK IV-mediated phosphorylation of CREB Reactome R-HSA-111932
    Calmodulin induced events Reactome R-HSA-111933
    Ca-dependent events Reactome R-HSA-111996
    CaM pathway Reactome R-HSA-111997
    G-protein mediated events Reactome R-HSA-112040
    PLC beta mediated events Reactome R-HSA-112043
    Neurotransmitter receptors and postsynaptic signal transmission Reactome R-HSA-112314
    Transmission across Chemical Synapses Reactome R-HSA-112315
    Neuronal System Reactome R-HSA-112316
    DAG and IP3 signaling Reactome R-HSA-1489509
    Signal Transduction Reactome R-HSA-162582
    Signaling by GPCR Reactome R-HSA-372790
    GPCR downstream signalling Reactome R-HSA-388396
    G alpha (i) signalling events Reactome R-HSA-418594
    Post NMDA receptor activation events Reactome R-HSA-438064
    CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Reactome R-HSA-442729
    Activation of NMDA receptors and postsynaptic events Reactome R-HSA-442755
    Intracellular signaling by second messengers Reactome R-HSA-9006925
    Activation of RAC1 downstream of NMDARs Reactome R-HSA-9619229
    Activation of AMPK downstream of NMDARs Reactome R-HSA-9619483
    Neuroinflammation and glutamatergic signaling (WP5083) WikiPathways WP5083_r120385
    CAMKK2 pathway (WP4874) WikiPathways WP4874_r124683
    AMP-activated protein kinase signaling (WP1403) WikiPathways WP1403_r123620
    Hippocampal synaptogenesis and neurogenesis (WP5231) WikiPathways WP5231_r123335
    VEGFA-VEGFR2 signaling pathway (WP3888) WikiPathways WP3888_r116782
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_153500 2 mRNA transcript variant 4 NC_000012 Reference
    NM_172216 2 mRNA transcript variant 3 NC_000012 Reference
    NM_153499 3 mRNA transcript variant 2 NC_000012 Reference
    XM_017018702 3 mRNA transcript variant X4 NC_000012 Reference
    NM_006549 4 mRNA transcript variant 1 NC_000012 Reference
    XM_005253824 3 mRNA transcript variant X11 NC_000012 Reference
    XM_047428105 1 mRNA transcript variant X9 NC_000012 Reference
    XM_005253822 3 mRNA transcript variant X5 NC_000012 Reference
    NM_172226 3 mRNA transcript variant 7 NC_000012 Reference
    XM_011537763 1 mRNA transcript variant X2 NC_000012 Reference
    NM_001270485 2 mRNA transcript variant 8 NC_000012 Reference
    XM_047428107 1 mRNA transcript variant X12 NC_000012 Reference
    XM_047428103 1 mRNA transcript variant X6 NC_000012 Reference
    XM_047428102 1 mRNA transcript variant X3 NC_000012 Reference
    XM_047428101 1 mRNA transcript variant X1 NC_000012 Reference
    NM_001270486 1 mRNA transcript variant 9 NC_000012 Reference
    XM_011537764 3 mRNA transcript variant X14 NC_000012 Reference
    XM_047428109 1 mRNA transcript variant X15 NC_000012 Reference
    NM_172215 3 mRNA transcript variant 6 NC_000012 Reference
    NM_172214 3 mRNA transcript variant 5 NC_000012 Reference
    XM_047428108 1 mRNA transcript variant X13 NC_000012 Reference
    XM_005253823 1 mRNA transcript variant X7 NC_000012 Reference
    XM_047428104 1 mRNA transcript variant X8 NC_000012 Reference
    XM_047428106 1 mRNA transcript variant X10 NC_000012 Reference