TM9SF1

transmembrane 9 superfamily member 1
General Information
Name transmembrane 9 superfamily member 1
Alias
  • transmembrane 9 superfamily member 1
  • MP70 protein family member
  • multispanning membrane protein (70kD)
  • transmembrane protein 9 superfamily member 1
Synonyms MP70 HMP70
Gene_family Transmembrane 9 superfamily members
organism Homo sapiens
entrez_id 10548
location 14q12
transcript_count 3
exon_count 6
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Predicted to be involved in protein localization to membrane. Predicted to be located in autophagosome membrane; cytoplasmic vesicle; and lysosomal membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]
      Stringdb Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family
      nextProt Plays an essential role in autophagy.
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    TM9SF1 BioGRID FBXW10 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID CDC123 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID B3GNT2 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
    TM9SF1 BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID POMK GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID PLD4 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    TM9SF1 BioGRID PLD3 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    TM9SF1 BioGRID LMNA GeneID BioGRID Proximity Label-MS
    TM9SF1 BioGRID TMPRSS4 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID DUOXA2 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID P2RY8 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID MFSD4A GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID SRPRB GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID RTN4 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID CLEC2D GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID TSPAN15 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID GPR182 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID GPR45 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID RTN3 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID GPR55 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID SLC6A5 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID TNFSF14 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID S1PR4 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID FZD7 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID VIPR1 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID UPK2 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID SLC1A1 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID PTAFR GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID OPRL1 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID ICAM2 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID GPM6B GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID LPAR1 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID S1PR1 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID ADGRE5 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID C5AR1 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID ATP1B1 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID RIGI GeneID BioGRID Affinity Capture-RNA
    TM9SF1 BioGRID ORF7b GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID ORF7b GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID E5 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID E5a GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID M GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID LMBR1L GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID PLEKHA4 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID ESR2 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID MTNR1A GeneID BioGRID Two-hybrid
    TM9SF1 BioGRID Spast GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID Cd2ap GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID CHMP4B GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID RNASEH1 GeneID BioGRID Two-hybrid
    TM9SF1 BioGRID TCOF1 GeneID BioGRID Two-hybrid
    TM9SF1 BioGRID P2RX7 GeneID BioGRID Two-hybrid
    TM9SF1 BioGRID ATP6V1B1 GeneID BioGRID Affinity Capture-MS
    TM9SF1 BioGRID MME GeneID BioGRID Affinity Capture-MS
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TM9SF1 FASTKD5 0 0 0 270 1 1
    TM9SF1 SURF4 0 0 81 204 1 1
    TM9SF1 GDE1 0 0 90 173 1 1
    TM9SF1 AGPAT4 0 0 0 225 1 1
    TM9SF1 NPC1L1 0 0 45 270 1 1
    TM9SF1 SMEK2 0 0 0 167 1 1
    TM9SF1 IPO4 0 0 210 695 1 1
    TM9SF1 ATG10 0 0 160 194 1 2
    TM9SF1 LPPR5 0 0 0 183 1 1
    TM9SF1 MAP1LC3B 0 0 144 230 1 2
    TM9SF1 MDH1B 0 0 156 189 1 1
    TM9SF1 YIPF1 0 0 45 285 1 1
    TM9SF1 CALCOCO2 0 0 161 161 1 2
    TM9SF1 ATG5 0 0 209 214 1 2
    TM9SF1 MRS2 0 0 202 397 1 1
    TM9SF1 SMEK1 0 0 0 167 1 1
    TM9SF1 ST8SIA2 0 0 160 159 1 1
    TM9SF1 GPR89A 0 0 96 157 1 1
    TM9SF1 PIM2 0 0 216 336 1 2
    TM9SF1 JTB 0 0 160 159 1 1
    TM9SF1 COG3 0 0 0 207 1 1
    TM9SF1 QRICH2 0 0 167 167 1 1
    TM9SF1 PPAP2A 0 0 0 183 1 1
    TM9SF1 AMBRA1 0 0 160 308 1 2
    TM9SF1 GOPC 0 0 205 495 1 2
    TM9SF1 ATOH8 0 0 261 261 1 1
    TM9SF1 SLC2A14 0 0 0 429 1 1
    TM9SF1 GABARAP 0 0 261 297 1 2
    TM9SF1 KIAA0226 0 0 169 519 1 1
    TM9SF1 RUNDC3A 0 0 0 156 1 1
    TM9SF1 PLA2G5 0 0 184 183 1 1
    TM9SF1 WIPI1 0 0 223 329 1 2
    TM9SF1 TMEM87A 0 0 0 158 1 1
    TM9SF1 SNX30 0 0 0 162 1 1
    TM9SF1 ATG7 0 0 183 221 1 2
    TM9SF1 ABCC10 0 0 0 157 1 1
    TM9SF1 TNPO1 0 0 150 186 1 1
    TM9SF1 COL4A3BP 0 0 142 291 1 1
    TM9SF1 VTI1B 0 0 138 250 1 2
    TM9SF1 KCNK2 0 0 134 152 1 1
    TM9SF1 LCLAT1 0 0 0 225 1 1
    TM9SF1 NHLH1 0 0 183 183 1 1
    TM9SF1 AGPAT2 0 0 0 162 1 1
    TM9SF1 PEX14 0 0 283 312 1 2
    TM9SF1 TMEM115 0 0 108 166 1 1
    TM9SF1 ATG16L1 0 0 150 165 1 2
    TM9SF1 SORBS2 0 0 161 209 1 1
    TM9SF1 NDRG3 0 0 75 152 1 1
    TM9SF1 AICDA 0 0 74 478 1 1
    TM9SF1 NANOGNB 0 0 184 515 1 1
    TM9SF1 AGPAT9 0 0 0 163 1 1
    TM9SF1 OS9 0 0 150 299 1 1
    TM9SF1 ATG101 0 0 202 296 1 2
    TM9SF1 LPCAT4 0 0 0 162 1 1
    TM9SF1 ATG4D 0 0 162 322 1 2
    TM9SF1 HELLS 0 0 0 188 1 1
    TM9SF1 RANBP6 0 0 0 254 1 1
    TM9SF1 COG7 0 0 0 158 1 1
    TM9SF1 ATG12 0 0 230 278 1 2
    TM9SF1 TM9SF2 0 0 610 242 1 1
    TM9SF1 SGPP1 0 0 67 206 1 1
    TM9SF1 EMC1 0 0 103 180 1 1
    TM9SF1 TMEM87B 0 0 0 158 1 1
    TM9SF1 SCAMP5 0 0 248 455 1 1
    TM9SF1 ABCC1 0 0 0 165 1 1
    TM9SF1 RUFY2 0 0 0 157 1 1
    TM9SF1 SNX4 0 0 0 162 1 1
    TM9SF1 BECN1 0 0 142 185 1 2
    TM9SF1 LPCAT2 0 0 0 162 1 1
    TM9SF1 ENSG00000260914 0 0 0 158 1 1
    TM9SF1 AGPAT6 0 0 0 163 1 1
    TM9SF1 SLC4A11 0 0 139 157 1 1
    TM9SF1 SNX2 0 0 0 163 1 1
    TM9SF1 HAX1 0 0 157 248 1 2
    TM9SF1 SLC35B2 0 0 0 181 1 1
    TM9SF1 UNC50 0 0 218 257 1 1
    TM9SF1 SNX7 0 0 0 162 1 2
    TM9SF1 ATP6V1A 129 0 55 179 1 1
    TM9SF1 HMGA2 0 0 0 153 1 1
    TM9SF1 PINK1 0 0 156 171 1 2
    TM9SF1 ZDHHC12 0 0 155 188 1 1
    TM9SF1 GDI2 0 0 171 244 1 1
    TM9SF1 KRT83 0 0 294 308 1 1
    TM9SF1 SLC2A5 0 0 0 160 1 1
    TM9SF1 TMED10 0 0 0 186 1 1
    TM9SF1 TMEM74 0 0 519 549 1 2
    TM9SF1 TMEM68 0 0 0 162 1 1
    TM9SF1 ABCC11 0 0 0 157 1 1
    TM9SF1 CEACAM19 0 0 146 164 1 1
    TM9SF1 DOLPP1 0 0 0 183 1 1
    TM9SF1 MBTPS1 0 0 0 155 1 1
    TM9SF1 IMPA1 0 0 202 345 1 1
    TM9SF1 ALG2 0 0 134 153 1 1
    TM9SF1 MRPL16 0 0 0 329 1 1
    TM9SF1 CAMK1G 0 0 90 166 1 1
    TM9SF1 ABCC12 0 0 0 165 1 1
    TM9SF1 TRIP11 0 0 0 194 1 1
    TM9SF1 SPPL3 0 0 85 202 1 1
    TM9SF1 ABCC9 0 0 0 165 1 1
    TM9SF1 COG5 0 0 0 204 1 1
    TM9SF1 GPR89B 0 0 95 156 1 1
    TM9SF1 SLC25A5 0 0 150 209 1 1
    TM9SF1 ATG3 0 0 122 276 1 2
    TM9SF1 RUFY3 0 0 0 157 1 1
    TM9SF1 ENSG00000250232 0 0 224 357 1 1
    TM9SF1 SLC2A4 0 0 0 160 1 1
    TM9SF1 EVA1A 0 0 560 567 1 2
    TM9SF1 LY6D 0 0 321 321 1 1
    TM9SF1 COG2 0 0 0 157 1 1
    TM9SF1 LPGAT1 0 0 0 354 1 1
    TM9SF1 GOLGA5 0 0 0 206 1 1
    TM9SF1 AGPAT3 0 0 0 225 1 1
    TM9SF1 THSD4 0 0 211 211 1 1
    TM9SF1 SGPP2 0 0 0 183 1 1
    TM9SF1 EMP1 0 0 134 152 1 1
    TM9SF1 LPCAT3 0 0 0 164 1 1
    TM9SF1 COL8A2 0 0 261 292 1 1
    TM9SF1 TMEM147 0 0 141 209 1 1
    TM9SF1 WDR45B 0 0 279 486 1 1
    TM9SF1 CHMP2A 0 0 0 211 1 2
    TM9SF1 TMSB4X 0 0 0 173 1 1
    TM9SF1 ATXN2L 0 0 95 151 1 1
    TM9SF1 WIPI2 0 0 90 168 1 2
    TM9SF1 LAPTM4A 0 0 180 191 1 1
    TM9SF1 FPGT 0 0 265 281 1 1
    TM9SF1 VPS51 0 0 140 202 1 1
    TM9SF1 KCNG2 0 0 96 152 1 1
    TM9SF1 WDR45 0 0 183 323 1 2
    TM9SF1 ATG4B 0 0 260 334 1 2
    TM9SF1 FXYD5 0 0 234 234 1 1
    TM9SF1 GEN1 0 0 0 217 1 1
    TM9SF1 DRAM1 0 0 166 387 1 2
    TM9SF1 FNBP1L 0 0 63 182 1 1
    TM9SF1 RASSF4 0 0 405 405 1 1
    TM9SF1 ABCC6 0 0 0 165 1 1
    TM9SF1 PLEKHA4 270 0 0 270 1 1
    TM9SF1 PGAP2 0 0 0 329 1 1
    TM9SF1 MOB1A 0 0 180 179 1 1
    TM9SF1 USP24 0 0 203 226 1 1
    TM9SF1 SNX29 0 0 0 176 1 1
    TM9SF1 TSPAN16 0 0 204 204 1 1
    TM9SF1 GRINA 0 0 74 171 1 1
    TM9SF1 LRRC19 0 0 143 165 1 1
    TM9SF1 TACR3 0 0 134 159 1 1
    TM9SF1 LPPR3 0 0 0 183 1 1
    TM9SF1 SPTSSA 0 0 207 225 1 1
    TM9SF1 PDP1 0 0 166 172 1 1
    TM9SF1 NANOG 0 0 435 589 1 1
    TM9SF1 FNBP1 0 0 63 181 1 1
    TM9SF1 SEC23B 0 0 0 183 1 2
    TM9SF1 SNX11 0 0 0 158 1 1
    TM9SF1 ABCC4 0 0 0 165 1 1
    TM9SF1 PPAPDC1B 0 0 0 183 1 1
    TM9SF1 IPO5 0 0 0 254 1 1
    TM9SF1 AUP1 0 0 206 381 1 1
    TM9SF1 CLEC2B 0 0 181 181 1 1
    TM9SF1 ADAMTS6 0 0 204 204 1 1
    TM9SF1 ABCC3 0 0 0 165 1 1
    TM9SF1 MFSD12 0 0 145 162 1 1
    TM9SF1 ABCC8 0 0 0 165 1 1
    TM9SF1 CHMP3 0 0 57 280 1 1
    TM9SF1 ATG16L2 0 0 341 441 1 2
    TM9SF1 ENSG00000158164 0 0 0 173 1 1
    TM9SF1 SLC3A2 0 0 128 208 1 1
    TM9SF1 SUPT20H 0 0 218 218 1 1
    TM9SF1 HSPA14 0 0 184 183 1 1
    TM9SF1 B4GALT5 0 0 143 161 1 1
    TM9SF1 RCN2 0 0 95 177 1 1
    TM9SF1 RAB24 0 0 218 436 1 2
    TM9SF1 SLC39A10 0 0 0 187 1 1
    TM9SF1 EBAG9 0 0 194 213 1 1
    TM9SF1 CRYGD 0 0 155 154 1 1
    TM9SF1 ENSG00000249884 0 0 58 280 1 1
    TM9SF1 SNX8 0 0 0 162 1 1
    TM9SF1 RAB1A 0 0 142 207 1 2
    TM9SF1 FEN1 0 0 82 567 1 1
    TM9SF1 CLEC2D 273 0 0 273 1 1
    TM9SF1 LPPR2 0 0 0 183 1 1
    TM9SF1 ANKRD2 0 0 181 193 1 1
    TM9SF1 CRCT1 0 0 279 279 1 1
    TM9SF1 NCLN 0 0 0 160 1 1
    TM9SF1 YIPF2 0 0 0 282 1 1
    TM9SF1 FREM1 0 0 211 222 1 1
    TM9SF1 SQSTM1 0 0 150 165 1 2
    TM9SF1 ATG13 0 0 155 286 1 2
    TM9SF1 SNX10 0 0 0 158 1 2
    TM9SF1 ALG5 0 0 94 180 1 1
    TM9SF1 ABCC5 0 0 0 165 1 1
    TM9SF1 ENSG00000158427 0 0 0 173 1 1
    TM9SF1 COPE 0 0 181 198 1 1
    TM9SF1 ZNF132 0 0 139 152 1 1
    TM9SF1 MPZL2 0 0 171 171 1 1
    TM9SF1 KIAA0226L 0 0 0 199 1 1
    TM9SF1 SNX1 0 0 0 163 1 1
    TM9SF1 PAPPA2 0 0 167 167 1 1
    TM9SF1 PTAR1 0 0 154 166 1 1
    TM9SF1 LAMP2 0 0 116 221 1 2
    TM9SF1 AGPAT1 0 0 0 162 1 1
    TM9SF1 TM9SF3 0 0 508 165 1 1
    TM9SF1 TM9SF4 0 0 689 202 1 1
    TM9SF1 MCOLN2 0 0 194 278 1 1
    TM9SF1 MCOLN3 0 0 181 268 1 1
    TM9SF1 SNX3 0 0 0 158 1 1
    TM9SF1 PPAPDC1A 0 0 0 183 1 1
    TM9SF1 LPCAT1 0 0 0 163 1 1
    TM9SF1 RBM43 0 0 140 158 1 1
    TM9SF1 SCAP 0 0 0 263 1 1
    TM9SF1 RER1 0 0 75 230 1 1
    TM9SF1 PTGES2 0 0 141 175 1 1
    TM9SF1 ZDHHC17 0 0 193 216 1 1
    TM9SF1 TPCN2 0 0 162 250 1 1
    TM9SF1 PLPPR1 0 0 0 183 1 1
    TM9SF1 RSPO2 0 0 125 206 1 1
    TM9SF1 AGPAT5 0 0 0 225 1 1
    TM9SF1 GABARAPL2 0 0 178 321 1 2
    TM9SF1 SLC39A9 0 0 0 264 1 1
    TM9SF1 SLC2A7 0 0 0 159 1 1
    TM9SF1 TRMT6 0 0 0 330 1 1
    TM9SF1 RAB33B 0 0 72 190 1 2
    TM9SF1 TPCN1 0 0 123 177 1 1
    TM9SF1 COPG1 0 0 0 179 1 1
    TM9SF1 PPAP2C 0 0 0 183 1 1
    TM9SF1 ATP6V1B1 129 0 66 185 1 1
    TM9SF1 MAP1LC3A 0 0 112 308 1 2
    TM9SF1 NAPG 0 0 92 151 1 1
    TM9SF1 RUNDC3B 0 0 0 156 1 1
    TM9SF1 COG4 0 0 0 162 1 1
    TM9SF1 ATP6V1H 0 0 0 159 1 1
    TM9SF1 VPS4A 0 0 0 158 1 1
    TM9SF1 LPPR4 0 0 0 183 1 1
    TM9SF1 COG6 0 0 0 212 1 1
    TM9SF1 LMLN 0 0 0 202 1 1
    TM9SF1 CHP1 0 0 81 160 1 1
    TM9SF1 PTPRU 0 0 138 195 1 1
    TM9SF1 VPS4B 0 0 0 267 1 1
    TM9SF1 DDIT3 0 0 123 165 1 2
    TM9SF1 SLC2A2 0 0 0 160 1 1
    TM9SF1 NCKAP1 0 0 188 222 1 1
    TM9SF1 NEDD8 0 0 0 260 1 1
    TM9SF1 SLC2A1 0 0 0 160 1 1
    TM9SF1 HCCS 0 0 204 240 1 1
    TM9SF1 COPB2 0 0 0 171 1 1
    TM9SF1 CFTR 0 0 60 189 1 1
    TM9SF1 TMEM33 0 0 298 395 1 1
    TM9SF1 SNX12 0 0 0 158 1 1
    TM9SF1 VDAC2 0 0 116 195 1 1
    TM9SF1 LOXHD1 0 0 86 187 1 1
    TM9SF1 SUCLG1 0 0 49 152 1 1
    TM9SF1 FITM2 0 0 90 188 1 1
    TM9SF1 TMEM165 0 0 364 447 1 1
    TM9SF1 MMP15 0 0 218 223 1 1
    TM9SF1 SPINK8 0 0 362 379 1 1
    TM9SF1 PHKB 0 0 85 167 1 1
    TM9SF1 CAMKK2 0 0 135 154 1 2
    TM9SF1 PPAP2B 0 0 0 183 1 1
    TM9SF1 ERMP1 0 0 358 392 1 1
    TM9SF1 NPC1 0 0 66 286 1 2
    TM9SF1 YIPF3 0 0 0 296 1 1
    TM9SF1 FKBP1B 0 0 154 172 1 1
    TM9SF1 MFAP4 0 0 180 181 1 1
    TM9SF1 ABCC2 0 0 0 165 1 1
    TM9SF1 COG1 0 0 67 219 1 1
    TM9SF1 TAPT1 0 0 122 209 1 1
    TM9SF1 TMSNB 0 0 0 173 1 1
    TM9SF1 SLC39A6 0 0 0 187 1 1
    TM9SF1 IRGM 0 0 184 221 1 2
    TM9SF1 A4GALT 0 0 219 251 1 1
    TM9SF1 LMBR1L 270 0 0 270 1 1
    TM9SF1 RUFY1 0 0 0 241 1 1
    TM9SF1 SYNGR2 0 0 245 353 1 1
    TM9SF1 TMSB10 0 0 0 173 1 1
    TM9SF1 TMEM134 0 0 161 161 1 1
    TM9SF1 ARCN1 0 0 81 252 1 1
    TM9SF1 SLC2A3 0 0 74 449 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0006914 Biological Process autophagy involved_in IEA
    GO:0072657 Biological Process protein localization to membrane involved_in IBA
    GO:0000421 Cellular Component autophagosome membrane located_in IEA
    GO:0031410 Cellular Component cytoplasmic vesicle located_in IEA
    GO:0005765 Cellular Component lysosomal membrane located_in IEA
    GO:0016020 Cellular Component membrane is_active_in IBA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_001289006 2 mRNA transcript variant 3 NC_000014 Reference
    NM_006405 7 mRNA transcript variant 1 NC_000014 Reference
    NM_001014842 3 mRNA transcript variant 2 NC_000014 Reference