RRAGB

Ras related GTP binding B
General Information
Name Ras related GTP binding B
Alias
  • ras-related GTP-binding protein B
  • GTP-binding protein ragB
  • rag B
Synonyms RAGB bA465E19.1
Gene_family Ras related GTP binding proteins
organism Homo sapiens
entrez_id 10325
location Xp11.21
transcript_count 16
exon_count 14
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
      Stringdb Ras-related GTP-binding protein B; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway; Belongs to the GTR/RAG GTP-binding protein family
      nextProt Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:18497260, PubMed:20381137, PubMed:24095279, PubMed:23723238). Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form (PubMed:18497260, PubMed:20381137, PubMed:24095279, PubMed:23723238). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:18497260, PubMed:20381137, PubMed:23723238). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    RRAGB BioGRID LAMTOR1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Co-localization; Proximity Label-MS
    RRAGB BioGRID RRAGA GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID LAMTOR5 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID LAMTOR3 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID LAMTOR4 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID SLC38A9 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID RRAGC GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    RRAGB BioGRID C9orf72 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID TRIM67 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID PLEKHM1 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID FLCN GeneID BioGRID Affinity Capture-Western
    RRAGB BioGRID LGALS9B GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID TPCN2 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID CHODL GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID RRAGD GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    RRAGB BioGRID MIB1 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID RPTOR GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
    RRAGB BioGRID SPG21 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID SSUH2 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID LAMTOR2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    RRAGB BioGRID RALBP1 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID TMOD1 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID RABGGTB GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID LGALS9 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID LGALS8 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID LGALS3 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID HLA-DQA1 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID GPR17 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID FPR2 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID CCR6 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID BLVRA GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID IMMP2L GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID TRIM37 GeneID BioGRID Affinity Capture-Western
    RRAGB BioGRID DEPDC5 GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    RRAGB BioGRID NPRL2 GeneID BioGRID Affinity Capture-Western
    RRAGB BioGRID TRIM16 GeneID BioGRID Affinity Capture-Western
    RRAGB BioGRID CD164L2 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID TGOLN2 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID NUDT1 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID CDH13 GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID LGALS9C GeneID BioGRID Affinity Capture-MS
    RRAGB BioGRID WDR24 GeneID BioGRID Affinity Capture-Western
    RRAGB BioGRID MTOR GeneID BioGRID Affinity Capture-Western; Reconstituted Complex
    RRAGB BioGRID TSC2 GeneID BioGRID Affinity Capture-Western
    RRAGB BioGRID RASAL1 GeneID BioGRID Co-fractionation
    RRAGB BioGRID YWHAB GeneID BioGRID Co-fractionation
    RRAGB BioGRID PDHB GeneID BioGRID Co-fractionation
    RRAGB BioGRID GSS GeneID BioGRID Co-fractionation
    RRAGB BioGRID CSE1L GeneID BioGRID Co-fractionation
    RRAGB BioGRID CKB GeneID BioGRID Co-fractionation
    RRAGB BioGRID APP GeneID BioGRID Reconstituted Complex
    RRAGB BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western
    RRAGB Protein RRAGD GeneID HPRD None
    RRAGB Protein RRAGC GeneID HPRD None
    StringDB
    A B experiments database textmining combined score hadb nhadb
    RRAGB PGD 0 0 0 152 1 1
    RRAGB KRAS 0 0 100 220 1 1
    RRAGB DTNBP1 0 0 57 309 1 1
    RRAGB TAS1R3 0 0 171 171 1 1
    RRAGB WBSCR16 0 0 0 220 1 1
    RRAGB ENSG00000270024 0 0 0 281 1 1
    RRAGB SLC25A33 0 0 113 355 1 1
    RRAGB TCIRG1 0 600 0 656 1 1
    RRAGB FRMPD4 0 0 0 165 1 1
    RRAGB RAP2C 0 0 0 228 1 1
    RRAGB TFE3 0 0 409 577 1 1
    RRAGB MID2 0 0 0 154 1 1
    RRAGB MCOLN3 0 0 0 229 1 1
    RRAGB NRAS 0 0 0 169 1 1
    RRAGB MCOLN2 0 0 0 229 1 1
    RRAGB DACH2 0 0 0 213 1 1
    RRAGB EIF4A2 0 0 140 199 1 1
    RRAGB MLST8 0 900 564 975 1 2
    RRAGB DEPDC5 486 900 654 988 1 1
    RRAGB FUNDC1 0 0 0 183 1 2
    RRAGB CXorf56 0 0 0 181 1 1
    RRAGB TMEM11 0 0 676 676 1 1
    RRAGB NPRL3 0 900 660 982 1 1
    RRAGB EIF1 0 0 90 178 1 1
    RRAGB RAB11B 0 0 0 220 1 1
    RRAGB DEPTOR 0 900 517 953 1 1
    RRAGB RRAGC 992 900 989 999 1 1
    RRAGB TRAPPC2 0 0 0 246 1 1
    RRAGB ARHGEF16 0 0 108 306 1 1
    RRAGB ARMCX5 0 0 0 171 1 1
    RRAGB AKAP8 0 0 0 203 1 1
    RRAGB WDR59 0 900 610 977 1 1
    RRAGB NFKBIL1 0 0 0 208 1 1
    RRAGB SERGEF 0 0 0 220 1 1
    RRAGB JADE3 0 0 0 176 1 1
    RRAGB LAMP2 270 0 505 676 1 2
    RRAGB AKAP11 0 0 0 208 1 1
    RRAGB ENOX2 0 0 0 181 1 1
    RRAGB ATP6V0A4 0 0 0 225 1 1
    RRAGB DCAF10 0 0 0 167 1 1
    RRAGB LPIN1 0 0 193 193 1 2
    RRAGB DAPK1 0 0 83 178 1 2
    RRAGB CTPS2 0 0 0 211 1 1
    RRAGB RRAGD 874 900 979 997 1 1
    RRAGB SLC9A7 0 0 0 220 1 1
    RRAGB TSC1 0 900 500 964 1 2
    RRAGB POLDIP3 0 0 243 242 1 1
    RRAGB ELOVL4 0 0 69 228 1 1
    RRAGB CXorf58 0 0 0 181 1 1
    RRAGB PIK3CB 0 0 53 291 1 1
    RRAGB SLC38A10 0 0 0 208 1 1
    RRAGB ULK2 0 0 134 268 1 2
    RRAGB ZC3H8 0 0 142 371 1 1
    RRAGB ARL17B 0 0 0 155 1 1
    RRAGB PIK3CG 0 0 0 282 1 1
    RRAGB CHEK1 0 0 0 200 1 1
    RRAGB C7orf62 0 0 292 480 1 1
    RRAGB BECN1 0 0 195 300 1 2
    RRAGB EEF1G 0 0 0 207 1 1
    RRAGB ATP6V0E1 0 600 45 604 1 1
    RRAGB SNAPIN 0 0 95 190 1 1
    RRAGB AKT1S1 0 900 517 954 1 1
    RRAGB EIF4EBP2 0 0 357 557 1 1
    RRAGB HAPLN4 0 0 120 201 1 1
    RRAGB EEF2K 0 0 232 231 1 2
    RRAGB ALG13 0 0 0 277 1 1
    RRAGB IL2 0 0 0 294 1 1
    RRAGB RASA4B 0 0 0 206 1 1
    RRAGB EIF2AK1 0 0 0 248 1 1
    RRAGB SQSTM1 270 0 247 426 1 2
    RRAGB RAD21 0 0 0 191 1 1
    RRAGB EDA2R 0 0 0 183 1 1
    RRAGB PRR5L 0 0 259 277 1 1
    RRAGB MAPK3 0 0 122 180 1 2
    RRAGB TCEAL1 0 0 0 151 1 1
    RRAGB RPS6KA6 0 0 112 362 1 1
    RRAGB FRG1B 0 0 151 150 1 1
    RRAGB EPRS 0 0 62 162 1 1
    RRAGB ATP6V1G2 0 600 0 609 1 1
    RRAGB SLC1A1 0 0 0 256 1 1
    RRAGB AK6 0 0 0 207 1 1
    RRAGB VWA5A 0 0 113 170 1 1
    RRAGB INS 0 0 292 292 1 1
    RRAGB ATG13 0 600 325 762 1 2
    RRAGB TMOD1 0 0 0 186 1 1
    RRAGB PRMT2 0 0 69 211 1 1
    RRAGB EIF4B 0 0 356 400 1 1
    RRAGB RANGAP1 0 0 0 211 1 1
    RRAGB ATP6V1B2 0 600 204 754 1 1
    RRAGB SPIN3 0 0 0 317 1 1
    RRAGB FGD6 0 0 0 328 1 1
    RRAGB EPHA7 0 0 0 173 1 1
    RRAGB PLD2 0 0 161 175 1 1
    RRAGB RNF152 0 800 248 914 1 1
    RRAGB CHIC1 0 0 0 327 1 1
    RRAGB DDX4 0 0 0 166 1 1
    RRAGB ATG101 0 600 181 675 1 2
    RRAGB TFEB 0 0 519 571 1 2
    RRAGB NHS 0 0 0 181 1 1
    RRAGB LAMTOR1 992 600 703 999 1 1
    RRAGB SLC25A14 0 0 0 156 1 1
    RRAGB ATP6V1E1 0 600 0 600 1 1
    RRAGB WWC3 0 0 0 171 1 1
    RRAGB MAP4K5 0 0 0 525 1 1
    RRAGB PLEKHF2 0 0 0 328 1 1
    RRAGB WDR61 0 0 0 167 1 1
    RRAGB RAB35 0 0 171 188 1 1
    RRAGB ATP6V0B 0 600 108 669 1 1
    RRAGB PI4KA 0 0 0 266 1 1
    RRAGB PCDH19 0 0 0 151 1 1
    RRAGB ZADH2 0 0 170 339 1 1
    RRAGB TBC1D7 0 0 544 544 1 2
    RRAGB RASA2 0 0 0 307 1 1
    RRAGB USP6 0 0 233 232 1 1
    RRAGB PIK3CD 0 0 0 282 1 1
    RRAGB ZRSR2 0 0 0 181 1 1
    RRAGB CNKSR2 0 0 0 153 1 1
    RRAGB RAB1A 0 0 358 436 1 2
    RRAGB IL13RA1 0 0 0 231 1 1
    RRAGB ATP6V1C1 0 600 445 774 1 1
    RRAGB TAF9B 0 0 0 207 1 1
    RRAGB SLC38A2 0 0 265 289 1 1
    RRAGB EIF5 0 0 134 194 1 1
    RRAGB ZZEF1 0 0 0 220 1 1
    RRAGB CXorf23 0 0 0 261 1 1
    RRAGB WDR41 0 0 150 203 1 2
    RRAGB EIF4G1 0 0 182 213 1 2
    RRAGB RHOA 0 0 74 246 1 1
    RRAGB PPP6C 0 0 0 288 1 1
    RRAGB ERCC1 0 0 0 198 1 1
    RRAGB CA5B 0 0 0 248 1 1
    RRAGB RIMS3 0 0 111 363 1 1
    RRAGB PJA1 0 0 0 158 1 1
    RRAGB GATSL3 0 900 566 958 1 1
    RRAGB ATP6V1E2 0 600 0 600 1 1
    RRAGB MIOS 0 900 681 980 1 1
    RRAGB SH3PXD2A 0 0 0 266 1 1
    RRAGB WDR55 0 0 175 364 1 1
    RRAGB ATM 0 0 94 156 1 1
    RRAGB C6orf211 0 0 0 181 1 1
    RRAGB POLR2J3 0 0 0 161 1 1
    RRAGB RAP2B 0 0 91 185 1 1
    RRAGB PRKAG3 0 900 0 908 1 1
    RRAGB HSD17B11 0 0 108 351 1 1
    RRAGB DAP 0 0 135 154 1 2
    RRAGB ATP1B4 0 0 0 152 1 1
    RRAGB POLR3G 0 0 108 266 1 1
    RRAGB BPHL 0 0 124 278 1 1
    RRAGB RAB9B 0 0 0 291 1 1
    RRAGB TTI1 0 0 294 294 1 1
    RRAGB DMD 0 0 0 181 1 1
    RRAGB RHOB 0 0 0 219 1 1
    RRAGB ATG7 0 0 134 194 1 2
    RRAGB BHLHB9 0 0 0 155 1 1
    RRAGB WDR7 0 0 0 167 1 1
    RRAGB ATP6V0A1 0 0 73 251 1 1
    RRAGB SLC3A2 0 0 310 325 1 1
    RRAGB OPHN1 0 0 74 170 1 1
    RRAGB IL10 0 0 0 292 1 1
    RRAGB UNC45B 0 0 0 185 1 1
    RRAGB STK32A 0 0 0 210 1 1
    RRAGB BOLA2B 0 0 0 440 1 1
    RRAGB SLC25A43 0 0 0 161 1 1
    RRAGB PPP2R5A 0 0 0 173 1 1
    RRAGB IRF4 0 0 0 245 1 1
    RRAGB TENM1 0 0 0 181 1 1
    RRAGB GABARAP 0 0 134 198 1 2
    RRAGB ACSL4 0 0 0 158 1 1
    RRAGB RAP2A 0 0 403 464 1 1
    RRAGB PTEN 0 0 213 429 1 2
    RRAGB EIF4A1 0 0 144 214 1 1
    RRAGB KLHL4 0 0 0 183 1 1
    RRAGB PI4KB 0 0 0 266 1 1
    RRAGB PRKAA2 0 900 350 950 1 2
    RRAGB XPO7 0 0 0 171 1 1
    RRAGB SGK2 0 0 67 301 1 1
    RRAGB AMBRA1 0 0 146 176 1 2
    RRAGB ARL17A 0 0 0 155 1 1
    RRAGB APOOL 0 0 0 154 1 1
    RRAGB PPEF1 0 0 0 190 1 1
    RRAGB MADD 0 0 288 288 1 1
    RRAGB EIF4EBP3 0 0 387 440 1 1
    RRAGB IMPA2 0 0 108 351 1 1
    RRAGB ABCB7 0 0 0 197 1 1
    RRAGB LGALS8 224 0 451 556 1 1
    RRAGB SH3PXD2B 0 0 0 266 1 1
    RRAGB ENSG00000272822 0 0 0 155 1 1
    RRAGB ELMO1 0 0 0 230 1 1
    RRAGB OLFML2B 0 0 125 358 1 1
    RRAGB SREBF1 0 0 143 184 1 2
    RRAGB SLC36A4 0 0 465 482 1 1
    RRAGB ENSG00000267318 0 0 0 210 1 1
    RRAGB SMCR8 0 0 167 167 1 2
    RRAGB PRKAB2 0 900 0 907 1 1
    RRAGB POLR2J 0 0 0 161 1 1
    RRAGB GEMIN8 0 0 0 213 1 1
    RRAGB EOMES 0 0 308 307 1 1
    RRAGB FLCN 0 900 729 984 1 1
    RRAGB SLC1A2 0 0 0 256 1 1
    RRAGB ATG4A 0 0 0 255 1 2
    RRAGB UBQLN2 0 0 0 181 1 2
    RRAGB KLHDC8B 0 0 0 208 1 1
    RRAGB SESN3 0 0 392 560 1 1
    RRAGB YIPF6 0 0 0 270 1 1
    RRAGB RPS6KA3 0 0 170 495 1 1
    RRAGB PIM2 0 0 67 168 1 2
    RRAGB RAC3 0 0 0 152 1 1
    RRAGB RPTOR 675 900 985 999 1 2
    RRAGB NEK9 0 0 0 220 1 1
    RRAGB PDCD4 0 0 108 158 1 1
    RRAGB ATG5 0 0 171 250 1 2
    RRAGB VARS 0 0 0 212 1 1
    RRAGB ATP6V1D 270 600 90 754 1 1
    RRAGB DOPEY1 0 0 143 275 1 1
    RRAGB CD164L2 289 0 0 288 1 1
    RRAGB DIAPH2 0 0 0 183 1 1
    RRAGB FAM46D 0 0 0 248 1 1
    RRAGB DYRK3 0 0 94 267 1 1
    RRAGB ATP6AP2 0 0 0 167 1 1
    RRAGB ATP4A 0 0 256 276 1 1
    RRAGB PRKAG2 0 900 108 929 1 1
    RRAGB RCBTB2 0 0 0 220 1 1
    RRAGB ESPN 0 0 0 190 1 1
    RRAGB RASA4 0 0 0 206 1 1
    RRAGB RPS6KB2 0 0 203 513 1 2
    RRAGB ADI1 0 0 90 251 1 1
    RRAGB FKBP1A 0 0 339 435 1 2
    RRAGB MBTPS2 0 0 0 275 1 1
    RRAGB TBC1D8B 0 0 0 153 1 1
    RRAGB DAPK3 0 0 0 190 1 2
    RRAGB RRP9 0 0 118 312 1 1
    RRAGB SCIN 0 0 0 201 1 1
    RRAGB PAK3 0 0 0 167 1 1
    RRAGB BLVRA 191 0 0 191 1 1
    RRAGB FAM136A 0 0 166 426 1 1
    RRAGB MAP1LC3B 0 0 183 188 1 2
    RRAGB KPTN 0 900 457 943 1 1
    RRAGB MTMR8 0 0 0 213 1 1
    RRAGB SESN2 0 900 566 966 1 2
    RRAGB ENSG00000228049 0 0 0 161 1 1
    RRAGB ARHGEF3 0 0 72 234 1 1
    RRAGB PCDH11X 0 0 0 155 1 1
    RRAGB RPS6KA1 0 0 297 406 1 1
    RRAGB ATP6V0A2 0 0 45 228 1 1
    RRAGB ATP6V0D2 0 600 0 668 1 1
    RRAGB PRKCA 0 0 150 187 1 1
    RRAGB ULK1 0 600 314 758 1 2
    RRAGB PLD1 0 0 296 308 1 1
    RRAGB FNIP1 0 900 562 955 1 1
    RRAGB TBP 0 0 53 236 1 1
    RRAGB RALA 0 0 99 192 1 1
    RRAGB IKBKG 0 0 57 188 1 1
    RRAGB RUVBL1 0 0 166 263 1 1
    RRAGB UPRT 0 0 0 237 1 1
    RRAGB CDCA7L 0 0 107 261 1 1
    RRAGB AKT3 0 0 96 295 1 1
    RRAGB PRKAB1 0 900 0 907 1 2
    RRAGB SKP2 0 800 57 807 1 1
    RRAGB PIGG 0 0 0 153 1 1
    RRAGB RUFY1 0 0 0 328 1 1
    RRAGB ATP12A 0 0 259 279 1 1
    RRAGB LAMTOR3 992 600 662 999 1 1
    RRAGB PIK3C2G 0 0 0 266 1 1
    RRAGB ERAP2 0 0 0 177 1 1
    RRAGB ARHGAP24 0 0 71 213 1 1
    RRAGB TMEM8C 0 0 97 153 1 1
    RRAGB CUL4B 0 0 0 214 1 1
    RRAGB EFNA5 0 0 716 716 1 1
    RRAGB NGDN 0 0 155 154 1 1
    RRAGB RPS6KA2 0 0 181 308 1 1
    RRAGB MAP4K1 0 0 0 439 1 1
    RRAGB ASB11 0 0 0 264 1 1
    RRAGB VPS39 0 0 470 812 1 1
    RRAGB CLCN4 0 0 0 165 1 1
    RRAGB LAMTOR2 992 600 652 998 1 1
    RRAGB FKBP1C 0 0 45 184 1 1
    RRAGB ITFG2 0 900 457 944 1 1
    RRAGB RUFY4 0 0 0 328 1 2
    RRAGB MOSPD2 0 0 0 181 1 1
    RRAGB ITSN2 0 0 0 202 1 1
    RRAGB TFEC 0 0 209 296 1 1
    RRAGB SH3BGRL 0 0 0 181 1 1
    RRAGB ACPP 0 0 0 209 1 1
    RRAGB RAB7A 0 0 370 590 1 2
    RRAGB BCAP31 0 0 0 222 1 1
    RRAGB PPP2R5C 0 0 0 187 1 1
    RRAGB NOL8 0 0 0 250 1 1
    RRAGB RAB1B 0 0 74 187 1 2
    RRAGB STK11 0 0 323 451 1 2
    RRAGB CASK 0 0 0 267 1 1
    RRAGB TAF7 0 0 0 257 1 1
    RRAGB CYLC1 0 0 0 171 1 1
    RRAGB AMMECR1 0 0 0 256 1 1
    RRAGB BOLA2 0 0 0 440 1 1
    RRAGB FGD5 0 0 0 328 1 1
    RRAGB LARP1 0 0 150 204 1 1
    RRAGB SLC38A3 0 0 75 185 1 1
    RRAGB RB1CC1 0 600 210 705 1 2
    RRAGB RHEBL1 0 0 348 415 1 1
    RRAGB LNPEP 0 0 0 256 1 1
    RRAGB ENSG00000272772 0 0 0 157 1 1
    RRAGB UVRAG 0 0 364 376 1 2
    RRAGB ICA1 0 0 81 297 1 1
    RRAGB AKT2 0 0 46 256 1 1
    RRAGB IGF1 0 0 169 169 1 1
    RRAGB IGF1R 0 0 66 165 1 1
    RRAGB ATP6V1G3 0 600 0 608 1 1
    RRAGB SMPDL3B 0 0 117 358 1 1
    RRAGB VPS11 0 0 0 158 1 2
    RRAGB LARS 0 0 610 817 1 1
    RRAGB SLC19A1 0 0 63 207 1 1
    RRAGB STK32C 0 0 0 210 1 1
    RRAGB RASAL1 129 0 0 278 1 1
    RRAGB FOXR2 0 0 112 204 1 1
    RRAGB ARL8B 0 0 145 189 1 1
    RRAGB ATP11C 0 0 0 273 1 1
    RRAGB SLC1A3 0 0 0 256 1 1
    RRAGB MYC 0 0 241 240 1 2
    RRAGB ITGAE 0 0 270 270 1 1
    RRAGB STK32B 0 0 0 210 1 1
    RRAGB SLC1A5 0 0 206 287 1 1
    RRAGB ILK 0 0 63 211 1 1
    RRAGB WDR44 0 0 0 155 1 1
    RRAGB SLC1A6 0 0 0 256 1 1
    RRAGB HERC2 0 0 0 220 1 1
    RRAGB PIK3CA 0 0 63 303 1 2
    RRAGB SLC1A4 0 0 0 188 1 1
    RRAGB ZDHHC9 0 0 0 154 1 1
    RRAGB UBL3 0 0 0 542 1 1
    RRAGB FOXR1 0 0 108 177 1 1
    RRAGB SF3A2 0 0 0 300 1 1
    RRAGB GLS 0 0 161 161 1 1
    RRAGB DDX3X 0 0 0 277 1 1
    RRAGB FNIP2 0 900 567 955 1 1
    RRAGB EEF2 0 0 181 195 1 1
    RRAGB ITCH 0 0 0 215 1 1
    RRAGB ATP6V1G1 0 600 0 608 1 1
    RRAGB FKBP1B 0 0 0 180 1 1
    RRAGB RICTOR 0 0 459 705 1 2
    RRAGB IGBP1 0 0 0 528 1 1
    RRAGB RUVBL2 0 0 81 230 1 1
    RRAGB TAF7L 0 0 0 246 1 1
    RRAGB MAP4K2 0 0 0 439 1 1
    RRAGB ARHGEF28 0 0 0 208 1 1
    RRAGB RRAS2 0 0 0 169 1 1
    RRAGB SLC13A3 0 0 95 158 1 1
    RRAGB CAMKK2 0 0 328 339 1 2
    RRAGB HUWE1 0 0 0 187 1 1
    RRAGB ZC3HAV1L 0 0 229 310 1 1
    RRAGB CROCC 0 0 90 203 1 1
    RRAGB POLR2J2 0 0 0 161 1 1
    RRAGB SZT2 0 900 375 935 1 1
    RRAGB RPGR 0 0 0 311 1 1
    RRAGB PPP2R3A 0 0 0 361 1 1
    RRAGB NPRL2 270 900 681 994 1 1
    RRAGB PPP2R5E 0 0 0 230 1 1
    RRAGB NGFRAP1 0 0 0 303 1 1
    RRAGB EEF1E1 0 0 0 151 1 1
    RRAGB FNTA 0 0 105 193 1 1
    RRAGB ZDHHC15 0 0 0 196 1 1
    RRAGB ITSN1 0 0 0 202 1 1
    RRAGB MKNK1 0 0 112 205 1 1
    RRAGB RHEB 0 600 758 956 1 2
    RRAGB DDIT4 0 0 397 396 1 1
    RRAGB APAF1 0 0 0 167 1 1
    RRAGB MAP4K3 0 0 394 700 1 1
    RRAGB EIF2AK4 0 0 249 493 1 1
    RRAGB VDAC2 0 0 0 347 1 1
    RRAGB ATP6V0D1 0 600 0 668 1 1
    RRAGB C7orf60 0 900 270 924 1 1
    RRAGB SNX12 0 0 0 199 1 1
    RRAGB RAB9A 0 0 0 293 1 2
    RRAGB RLIM 0 0 0 186 1 1
    RRAGB GSTT2B 0 0 0 151 1 1
    RRAGB PDPK1 0 0 61 156 1 2
    RRAGB NET1 0 0 0 209 1 1
    RRAGB ELMO2 0 0 0 230 1 1
    RRAGB LAMTOR4 992 600 685 999 1 1
    RRAGB MCOLN1 0 0 266 410 1 1
    RRAGB OCRL 0 0 0 153 1 1
    RRAGB LAMP1 270 0 367 593 1 2
    RRAGB PRKDC 0 0 0 440 1 2
    RRAGB RANBP3 0 0 0 169 1 1
    RRAGB MARS 0 0 0 208 1 1
    RRAGB EIF4E 0 900 240 926 1 1
    RRAGB METAP2 0 0 420 426 1 1
    RRAGB RPS6KB1 0 900 559 971 1 2
    RRAGB EFHC2 0 0 0 267 1 1
    RRAGB B4GALT7 0 0 0 190 1 1
    RRAGB TRIM16 270 0 141 346 1 2
    RRAGB KCNA1 0 0 306 306 1 1
    RRAGB PRPS2 0 0 91 183 1 1
    RRAGB SGK1 0 0 219 414 1 1
    RRAGB IRS1 0 0 234 315 1 1
    RRAGB PIK3C2B 0 0 0 266 1 1
    RRAGB PCYT1B 0 0 52 182 1 1
    RRAGB MSL3 0 0 0 226 1 1
    RRAGB ENSG00000273637 0 0 0 708 1 1
    RRAGB IPMK 0 0 258 274 1 1
    RRAGB SESN1 0 900 493 960 1 2
    RRAGB ATP6V0C 0 600 53 647 1 2
    RRAGB MED9 0 0 134 366 1 1
    RRAGB PPP2R5D 0 0 0 187 1 1
    RRAGB ATR 0 0 0 266 1 1
    RRAGB SLC7A5 0 0 325 342 1 1
    RRAGB RAB10 0 0 282 282 1 1
    RRAGB LHFPL1 0 0 0 156 1 1
    RRAGB ATP6V1F 0 600 0 613 1 1
    RRAGB ARF5 0 0 0 155 1 1
    RRAGB RCBTB1 0 0 0 220 1 1
    RRAGB HPDL 0 0 0 208 1 1
    RRAGB RCC1 0 0 43 555 1 1
    RRAGB CXorf22 0 0 0 215 1 1
    RRAGB FLT3LG 0 0 306 306 1 1
    RRAGB DCAF12L1 0 0 0 215 1 1
    RRAGB FAM122C 0 0 0 181 1 1
    RRAGB PRKAA1 0 900 47 927 1 2
    RRAGB SMTNL2 0 0 150 336 1 1
    RRAGB DNAJC5 0 0 70 231 1 1
    RRAGB KDM6A 0 0 0 174 1 1
    RRAGB VDAC3 0 0 0 246 1 1
    RRAGB FOXO3 0 0 94 293 1 2
    RRAGB MTOR 270 900 731 996 1 2
    RRAGB YWHAB 129 600 0 658 1 1
    RRAGB MAPKAP1 0 0 218 391 1 1
    RRAGB BZW2 0 0 142 386 1 1
    RRAGB EEA1 0 0 112 235 1 1
    RRAGB WDR24 270 900 663 985 1 1
    RRAGB WDR72 0 0 0 167 1 1
    RRAGB MOSPD1 0 0 0 152 1 1
    RRAGB NOC2L 0 0 96 339 1 1
    RRAGB RCC2 0 0 0 173 1 1
    RRAGB ARAF 0 0 57 376 1 1
    RRAGB ATP6V0E2 0 600 0 600 1 1
    RRAGB L3HYPDH 0 0 0 196 1 1
    RRAGB GPR112 0 0 0 167 1 1
    RRAGB GATSL2 0 900 466 948 1 1
    RRAGB UTP14A 0 0 0 153 1 1
    RRAGB WDSUB1 0 0 0 167 1 1
    RRAGB TRIM37 270 0 93 309 1 1
    RRAGB UBE2A 0 0 0 183 1 1
    RRAGB PLEK 0 0 142 161 1 1
    RRAGB LGALS3 279 0 46 282 1 1
    RRAGB RPS6 0 0 294 421 1 1
    RRAGB PIK3C3 0 0 402 597 1 2
    RRAGB RTN3 0 0 0 187 1 1
    RRAGB BRWD3 0 0 0 206 1 1
    RRAGB RAB12 0 0 113 204 1 2
    RRAGB POLR1D 0 0 0 469 1 1
    RRAGB RASA3 0 0 0 307 1 1
    RRAGB SEC13 0 900 518 972 1 1
    RRAGB ARF3 0 0 90 198 1 1
    RRAGB SLC1A7 0 0 456 512 1 1
    RRAGB ASAP1 0 0 0 157 1 1
    RRAGB ST6GALNAC4 0 0 112 354 1 1
    RRAGB ATP6V1H 0 600 0 634 1 1
    RRAGB YPEL5 0 0 125 360 1 1
    RRAGB HIF1A 0 0 134 188 1 2
    RRAGB ACOT9 0 0 0 162 1 1
    RRAGB CCZ1 0 0 155 174 1 1
    RRAGB SH3BP4 0 900 756 974 1 1
    RRAGB MITF 0 0 124 481 1 1
    RRAGB RRAGA 913 900 890 991 1 2
    RRAGB PRMT5 0 0 0 260 1 1
    RRAGB PRKCB 0 0 85 233 1 2
    RRAGB RCCD1 0 0 0 220 1 1
    RRAGB RAB11A 0 0 51 326 1 1
    RRAGB RAB5A 0 0 171 193 1 2
    RRAGB POLR1B 0 0 95 234 1 1
    RRAGB RAC2 0 0 181 276 1 1
    RRAGB GPM6A 0 0 81 239 1 1
    RRAGB VDAC1 0 0 0 181 1 2
    RRAGB NME7 0 0 103 167 1 1
    RRAGB LGALS9C 714 0 0 714 1 1
    RRAGB TRRAP 0 0 47 271 1 1
    RRAGB RAB7B 0 0 370 472 1 1
    RRAGB PIK3C2A 0 0 0 266 1 2
    RRAGB TGFBRAP1 0 0 113 495 1 1
    RRAGB IBTK 0 0 0 173 1 1
    RRAGB TSC2 270 900 699 991 1 2
    RRAGB F2R 0 0 0 199 1 1
    RRAGB PRKAG1 0 900 85 915 1 1
    RRAGB ERAP1 0 0 0 297 1 1
    RRAGB GTF2H5 0 0 96 204 1 1
    RRAGB ENSG00000270249 0 0 0 267 1 1
    RRAGB SLC38A1 0 0 181 208 1 1
    RRAGB IFRD2 0 0 151 439 1 1
    RRAGB MAF1 0 900 157 916 1 1
    RRAGB KLF8 0 0 57 175 1 1
    RRAGB PPP2R3B 0 0 113 662 1 1
    RRAGB TGOLN2 199 0 0 199 1 1
    RRAGB ALOXE3 0 0 93 232 1 1
    RRAGB TEP1 0 0 0 189 1 1
    RRAGB ATP6V1B1 0 600 0 699 1 1
    RRAGB BOLA2-SMG1P6 0 0 0 440 1 1
    RRAGB HRAS 0 0 123 240 1 1
    RRAGB RANBP17 0 0 0 154 1 1
    RRAGB PLK4 0 0 48 308 1 1
    RRAGB LIPM 0 0 108 175 1 1
    RRAGB C17orf59 0 0 405 405 1 1
    RRAGB ELMO3 0 0 0 175 1 1
    RRAGB FYCO1 0 0 48 333 1 2
    RRAGB SF3A3 0 0 91 302 1 1
    RRAGB AKT1 0 900 346 946 1 2
    RRAGB CDH13 130 0 0 252 1 1
    RRAGB PIK3R4 0 0 290 348 1 2
    RRAGB CD4 0 0 57 156 1 1
    RRAGB ALS2 0 0 0 220 1 1
    RRAGB TAB3 0 0 0 248 1 2
    RRAGB REEP6 0 0 127 200 1 1
    RRAGB WDR73 0 0 151 382 1 1
    RRAGB SGK3 0 0 0 281 1 1
    RRAGB ATP6V1C2 0 600 0 609 1 1
    RRAGB FANCB 0 0 0 154 1 1
    RRAGB RAN 0 0 139 269 1 1
    RRAGB SLC38A7 0 0 338 359 1 1
    RRAGB FKBP8 0 0 358 367 1 1
    RRAGB PPP2R3C 0 0 0 190 1 1
    RRAGB RXFP1 0 0 0 201 1 1
    RRAGB SMG1 0 0 113 482 1 1
    RRAGB PRR5 0 0 390 390 1 1
    RRAGB SLC36A1 0 0 413 432 1 1
    RRAGB FGFR2 0 0 0 248 1 1
    RRAGB PDK3 0 0 0 158 1 1
    RRAGB XIAP 0 0 0 181 1 1
    RRAGB HECTD4 0 0 0 220 1 1
    RRAGB EIF2B2 0 0 94 255 1 1
    RRAGB TRIAP1 0 0 108 151 1 1
    RRAGB ATG14 0 0 184 198 1 2
    RRAGB ARF4 0 0 0 155 1 1
    RRAGB LARS2 0 0 602 818 1 1
    RRAGB ZNF41 0 0 0 223 1 1
    RRAGB MED14 0 0 0 177 1 1
    RRAGB TUBB1 0 0 74 231 1 1
    RRAGB LTV1 0 0 265 579 1 1
    RRAGB TAS1R1 0 0 167 167 1 1
    RRAGB THOC2 0 0 0 156 1 1
    RRAGB NDUFB6 0 0 81 177 1 1
    RRAGB CDC16 0 0 194 204 1 1
    RRAGB USP9X 0 0 0 176 1 1
    RRAGB INO80 0 0 0 150 1 1
    RRAGB PIN4 0 0 0 214 1 1
    RRAGB ESRRA 0 0 307 307 1 1
    RRAGB GRB10 0 0 202 207 1 1
    RRAGB RHOC 0 0 0 219 1 1
    RRAGB EIF4EBP1 0 900 517 953 1 1
    RRAGB PFKFB3 0 0 400 400 1 1
    RRAGB SEH1L 0 900 602 976 1 1
    RRAGB TPCN2 135 0 340 405 1 1
    RRAGB ARF1 0 0 394 466 1 1
    RRAGB ZKSCAN3 0 0 227 226 1 2
    RRAGB ANKRD6 0 0 95 336 1 1
    RRAGB C12orf66 0 900 469 945 1 1
    RRAGB ATP6V1A 0 600 181 769 1 1
    RRAGB YME1L1 0 0 123 289 1 1
    RRAGB MAP3K1 0 0 0 169 1 1
    RRAGB ITM2B 0 0 0 203 1 1
    RRAGB IL1RAPL1 0 0 0 155 1 1
    RRAGB KRBOX4 0 0 0 215 1 1
    RRAGB ZFX 0 0 0 181 1 1
    RRAGB HDX 0 0 0 323 1 1
    RRAGB PLEKHF1 0 0 0 328 1 2
    RRAGB CCZ1B 0 0 181 199 1 1
    RRAGB KAL1 0 0 0 153 1 1
    RRAGB SLC38A9 992 600 686 998 1 1
    RRAGB LAMTOR5 992 600 603 998 1 1
    RRAGB KLHL15 0 0 0 161 1 1
    RRAGB CTSO 0 0 123 368 1 1
    RRAGB LGALS9 363 0 0 363 1 1
    RRAGB HERC1 0 0 0 220 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005525 Molecular Function GTP binding enables IBA
    GO:0005525 Molecular Function GTP binding enables IDA
    GO:0005525 Molecular Function GTP binding enables IMP
    GO:0003924 Molecular Function GTPase activity enables IBA
    GO:0051020 Molecular Function GTPase binding enables IPI
    GO:0032561 Molecular Function guanyl ribonucleotide binding enables IDA
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0034198 Biological Process cellular response to amino acid starvation involved_in IGI
    GO:0071230 Biological Process cellular response to amino acid stimulus involved_in IMP
    GO:1990253 Biological Process cellular response to leucine starvation involved_in IMP
    GO:0009267 Biological Process cellular response to starvation involved_in IBA
    GO:0010507 Biological Process negative regulation of autophagy involved_in IBA
    GO:0032008 Biological Process positive regulation of TOR signaling involved_in IMP
    GO:1904263 Biological Process positive regulation of TORC1 signaling involved_in IBA
    GO:1904263 Biological Process positive regulation of TORC1 signaling involved_in IMP
    GO:0008104 Biological Process protein localization involved_in IMP
    GO:0032006 Biological Process regulation of TOR signaling involved_in IGI
    GO:1990131 Cellular Component Gtr1-Gtr2 GTPase complex part_of IBA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005829 Cellular Component cytosol located_in TAS
    GO:0005765 Cellular Component lysosomal membrane located_in HDA
    GO:0005764 Cellular Component lysosome is_active_in IBA
    GO:0005764 Cellular Component lysosome located_in IDA
    GO:0005634 Cellular Component nucleus is_active_in IBA
    Pathways
    Name DB ID
    2q37 copy number variation syndrome (WP5224) WikiPathways WP5224_r122740
    Target of rapamycin signaling (WP1471) WikiPathways WP1471_r123616
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_148685 2 miscRNA transcript variant 7 NC_000023 Reference
    NR_148691 2 miscRNA transcript variant 13 NC_000023 Reference
    NR_148692 2 miscRNA transcript variant 14 NC_000023 Reference
    NR_148687 2 miscRNA transcript variant 9 NC_000023 Reference
    NR_148689 2 miscRNA transcript variant 11 NC_000023 Reference
    NR_148684 2 miscRNA transcript variant 6 NC_000023 Reference
    NR_148686 2 miscRNA transcript variant 8 NC_000023 Reference
    NR_148688 2 miscRNA transcript variant 10 NC_000023 Reference
    NR_148683 2 miscRNA transcript variant 5 NC_000023 Reference
    NR_148690 2 miscRNA transcript variant 12 NC_000023 Reference
    NM_016656 4 mRNA transcript variant RAGBl NC_000023 Reference
    NM_006064 5 mRNA transcript variant RAGBs NC_000023 Reference
    NM_001354011 2 mRNA transcript variant 3 NC_000023 Reference
    NM_001354013 2 mRNA transcript variant 4 NC_000023 Reference
    XM_017029218 3 mRNA transcript variant X1 NC_000023 Reference
    XM_047441764 1 mRNA transcript variant X2 NC_000023 Reference