NBR2

neighbor of BRCA1 lncRNA 2
General Information
Name neighbor of BRCA1 lncRNA 2
Alias
  • Neighbor of BRCA1 gene 2 protein
  • Next to BRCA1 gene 2 protein
  • neighbor of BRCA1 gene 2 (non-protein coding)
Synonyms NCRNA00192
Gene_family Long non-coding RNAs with non-systematic symbols
organism Homo sapiens
entrez_id 10230
location 17q21.31
transcript_count 2
exon_count 10
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    NBR2 BioGRID AGO4 GeneID BioGRID Affinity Capture-MS
    NBR2 BioGRID GMIP GeneID BioGRID Affinity Capture-MS
    NBR2 BioGRID PITRM1 GeneID BioGRID Affinity Capture-MS
    NBR2 BioGRID SNRPA1 GeneID BioGRID Proximity Label-MS
    NBR2 BioGRID KRAS GeneID BioGRID Synthetic Lethality
    StringDB
    A B experiments database textmining combined score hadb nhadb
    Ontologies
    ID Category Term Effect Evidence PubMed
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NR_138145 1 ncRNA transcript variant 2 NC_000017 Reference
    NR_003108 2 ncRNA transcript variant 1 NC_000017 Reference