TRIM13

tripartite motif containing 13
General Information
Name tripartite motif containing 13
Alias
  • E3 ubiquitin-protein ligase TRIM13
  • B-cell chronic lymphocytic leukemia tumor suppressor Leu5
  • CLL-associated RING finger
  • RING finger protein 77
  • RING-type E3 ubiquitin transferase TRIM13
  • leukemia-associated protein 5
  • putative tumor suppressor RFP2
  • ret finger protein 2
  • tripartite motif protein 13
  • tripartite motif-containing protein 13
Synonyms Leu5 RNF77 DLEU5 CAR LEU5 RFP2
Gene_family Ring finger proteins|Tripartite motif family
organism Homo sapiens
entrez_id 10206
location 13q14.2
transcript_count 4
exon_count 4
Cross References
Location
by NCBI GRCh38.p14
    Summary
      Entrez This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
      Stringdb E3 ubiquitin-protein ligase TRIM13; E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor; Belon [...]
      nextProt Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386). Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809). Participates as well in T-cell receptor-mediated NF-kappa-B activation (PubMed:25088585). In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375).
    Interactions
    NCBI
    A A.Source B B.DB B.Source Description PubMed
    TRIM13 BioGRID CEACAM6 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID UBE2C GeneID BioGRID Reconstituted Complex
    TRIM13 BioGRID UBE2L6 GeneID BioGRID Reconstituted Complex
    TRIM13 BioGRID CCNA1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    TRIM13 BioGRID SQSTM1 GeneID BioGRID Affinity Capture-Western; Co-localization
    TRIM13 BioGRID UBE2N GeneID BioGRID Reconstituted Complex
    TRIM13 BioGRID UBE2L3 GeneID BioGRID Reconstituted Complex
    TRIM13 BioGRID UBE2H GeneID BioGRID Reconstituted Complex
    TRIM13 BioGRID UBE2E1 GeneID BioGRID Reconstituted Complex
    TRIM13 BioGRID UBE2D3 GeneID BioGRID Reconstituted Complex
    TRIM13 BioGRID UBE2D2 GeneID BioGRID Reconstituted Complex
    TRIM13 BioGRID UBE2K GeneID BioGRID Reconstituted Complex
    TRIM13 BioGRID CDC34 GeneID BioGRID Reconstituted Complex
    TRIM13 BioGRID ESYT1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID ESYT2 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID Rab18 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID TGOLN2 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID ROR2 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID INSR GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID IGF1R GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID FLT4 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID FGFR1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID EPHA8 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID EGFR GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID ALK GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID ORF1ab GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID ORF1ab GeneID BioGRID Affinity Capture-Western
    TRIM13 BioGRID RNF43 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RAB7A GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RAC3 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID CDC42 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID RHOH GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID RHOG GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID RHOA GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID S GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID CLEC4D GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID TMPRSS11B GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID CLEC4E GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID TMPRSS2 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID FAM234B GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID MARCHF4 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID TTYH1 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID TMEM9B GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID NPLOC4 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID ELOVL2 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID COMMD10 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID LRRN2 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID ABCG2 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID TMEM35B GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID TMEM130 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID CCDC107 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID PDE3A GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID MVK GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID KIR3DL2 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID KCNF1 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID TEX28 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID NEDD4L GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID RAB35 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID CKAP4 GeneID BioGRID Affinity Capture-MS; Proximity Label-MS
    TRIM13 BioGRID SEC61B GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID MTX2 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID BCAP31 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID PPIF GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID NUP155 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RAB9A GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID COPS2 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID RAB11A GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID STX7 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID REEP5 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID TMPO GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID SEC62 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID TMBIM6 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID STX4 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID STIM1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID SSR1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RPN2 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RPN1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RAB5A GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RAB4A GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RAB3B GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID PXMP2 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID PPARG GeneID BioGRID Affinity Capture-Western
    TRIM13 BioGRID LMAN1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID KRAS GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID IDH2 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID NR4A1 GeneID BioGRID Affinity Capture-Western
    TRIM13 BioGRID HMOX2 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID GJA1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID EMD GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID CYP2C9 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID CXADR GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID AP3S1 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID DHFR2 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID SYNE3 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID GJD3 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID LNPK GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID HSD3B7 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID TMEM43 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID DERL1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID AASDHPPT GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID ELOVL5 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID ATP13A1 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID LRRC59 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID HSD17B11 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID VPS4A GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID B3GAT1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID LAMP3 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID TMT1A GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID PANX1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID ATP2A1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID DNAJC25 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID DNAJC22 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID DNAJC1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID SEC63 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID SLC25A46 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RHOT2 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RMDN3 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID FKBP8 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID ST7 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID PTPN1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID WIPI2 GeneID BioGRID Co-localization
    TRIM13 BioGRID TRIM13 GeneID BioGRID Biochemical Activity; Co-fractionation
    TRIM13 BioGRID ATG12 GeneID BioGRID Co-localization
    TRIM13 BioGRID BECN1 GeneID BioGRID Affinity Capture-Western
    TRIM13 BioGRID PIK3C3 GeneID BioGRID Affinity Capture-Western
    TRIM13 BioGRID SYVN1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID OTULINL GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID RHBDD1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID UNC93B1 GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID LAMP1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID CANX GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID CTDNEP1 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID PTPRN GeneID BioGRID Affinity Capture-MS
    TRIM13 BioGRID TRAF6 GeneID BioGRID Affinity Capture-Western
    TRIM13 BioGRID TMEM17 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID EVC2 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID TCTN2 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID TMEM216 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID TCTN3 GeneID BioGRID Proximity Label-MS
    TRIM13 BioGRID MDM2 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    TRIM13 BioGRID AKT1 GeneID BioGRID Affinity Capture-Western; Biochemical Activity
    TRIM13 BioGRID GMCL1 GeneID BioGRID Two-hybrid
    TRIM13 BioGRID IKBKG GeneID BioGRID Affinity Capture-Western
    TRIM13 BioGRID VCP GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    TRIM13 BioGRID DDOST GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    TRIM13 BioGRID CALM1 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    TRIM13 BioGRID ATP2A2 GeneID BioGRID Affinity Capture-MS; Affinity Capture-Western
    TRIM13 BioGRID ZFYVE1 GeneID BioGRID Co-localization
    TRIM13 BioGRID ROBO2 GeneID BioGRID Two-hybrid
    TRIM13 BioGRID CACNA1C GeneID BioGRID Affinity Capture-Western
    TRIM13 BioGRID ARHGDIA GeneID BioGRID Two-hybrid
    StringDB
    A B experiments database textmining combined score hadb nhadb
    TRIM13 FTSJ3 0 0 113 208 1 1
    TRIM13 GABARAP 0 0 60 180 1 2
    TRIM13 HIST1H4A 0 0 0 153 1 1
    TRIM13 UBA52 0 900 0 900 1 1
    TRIM13 KLHL28 0 0 59 158 1 1
    TRIM13 WT1 0 0 52 179 1 1
    TRIM13 CCKBR 0 0 213 213 1 1
    TRIM13 ONECUT2 0 0 150 202 1 1
    TRIM13 RHOT2 117 0 0 170 1 1
    TRIM13 TXNDC17 0 0 429 486 1 1
    TRIM13 POLE2 0 0 324 338 1 1
    TRIM13 PLEKHG4B 0 0 0 162 1 1
    TRIM13 FMN1 0 0 0 167 1 1
    TRIM13 VWA1 0 0 170 169 1 1
    TRIM13 DERL3 0 0 133 158 1 1
    TRIM13 TAC1 0 0 507 507 1 1
    TRIM13 TRAT1 0 0 564 582 1 1
    TRIM13 ISG15 0 0 180 328 1 1
    TRIM13 PIAS3 0 0 113 227 1 1
    TRIM13 EHBP1 0 0 88 166 1 1
    TRIM13 IKBKG 270 0 184 387 1 1
    TRIM13 SEL1L 0 600 193 663 1 1
    TRIM13 GNA11 0 0 203 203 1 1
    TRIM13 PPP1CA 0 0 145 163 1 1
    TRIM13 REPS1 0 0 397 425 1 1
    TRIM13 PTPN1 117 0 0 168 1 1
    TRIM13 PUM1 0 0 0 199 1 1
    TRIM13 KCTD19 0 0 68 199 1 1
    TRIM13 ENOX1 0 0 127 274 1 1
    TRIM13 TMX4 0 0 122 245 1 1
    TRIM13 RASL11A 0 0 166 179 1 1
    TRIM13 ARRDC4 0 0 134 188 1 1
    TRIM13 IFITM5 0 0 73 217 1 1
    TRIM13 MID2 0 0 296 199 1 1
    TRIM13 SLC4A11 0 0 0 190 1 1
    TRIM13 RNF122 0 0 267 296 1 1
    TRIM13 NANOS2 0 0 0 156 1 1
    TRIM13 NANOS1 0 0 0 156 1 1
    TRIM13 DDX31 0 0 0 221 1 1
    TRIM13 TMEM115 0 0 45 464 1 1
    TRIM13 TRIM68 0 0 391 225 1 1
    TRIM13 APLNR 0 0 179 213 1 1
    TRIM13 SST 0 0 329 329 1 1
    TRIM13 HIST2H4A 0 0 0 153 1 1
    TRIM13 TRIM44 0 0 305 533 1 1
    TRIM13 PLEKHG4 0 0 109 275 1 1
    TRIM13 NDE1 0 0 538 538 1 1
    TRIM13 ATG12 273 0 74 298 1 2
    TRIM13 TRIM56 0 0 324 184 1 1
    TRIM13 PPIA 0 0 448 455 1 1
    TRIM13 TRPC4 0 0 684 684 1 1
    TRIM13 OS9 0 600 136 640 1 1
    TRIM13 GNA15 0 0 243 242 1 1
    TRIM13 MARCH5 0 0 122 186 1 1
    TRIM13 TBK1 0 0 140 290 1 2
    TRIM13 CACNA1A 0 0 60 157 1 1
    TRIM13 HIST1H4D 0 0 0 153 1 1
    TRIM13 YPEL2 0 0 144 214 1 1
    TRIM13 SLC25A42 0 0 370 370 1 1
    TRIM13 SPINT2 0 0 202 202 1 1
    TRIM13 TRIM29 0 0 360 508 1 1
    TRIM13 TRIM58 0 0 260 179 1 1
    TRIM13 MPHOSPH8 0 0 0 157 1 1
    TRIM13 BBOX1 0 0 469 584 1 1
    TRIM13 RNF139 0 0 456 468 1 1
    TRIM13 XPNPEP3 0 0 136 311 1 1
    TRIM13 TXNDC9 0 0 0 154 1 1
    TRIM13 BNIP1 0 0 143 289 1 2
    TRIM13 TRIM28 0 0 379 441 1 2
    TRIM13 GMPS 0 0 89 173 1 1
    TRIM13 RNF103 0 0 341 455 1 1
    TRIM13 DLD 0 0 519 539 1 1
    TRIM13 SSRP1 0 0 0 196 1 1
    TRIM13 EHD1 0 0 95 170 1 1
    TRIM13 GPT 0 0 93 354 1 1
    TRIM13 AGO3 0 0 0 189 1 1
    TRIM13 RNASEH2B 0 0 180 179 1 1
    TRIM13 KLHL33 0 0 184 190 1 1
    TRIM13 TPM3 0 0 113 231 1 1
    TRIM13 DERL2 0 600 83 641 1 1
    TRIM13 SUMO1 0 0 134 183 1 1
    TRIM13 HIST1H4C 0 0 0 153 1 1
    TRIM13 DDX10 0 0 0 150 1 1
    TRIM13 VIP 0 0 181 181 1 1
    TRIM13 UBE2W 0 0 57 165 1 1
    TRIM13 RNF185 0 0 325 361 1 1
    TRIM13 PAFAH1B1 0 0 397 405 1 1
    TRIM13 UBE2J1 0 0 194 246 1 1
    TRIM13 SDF2L1 0 0 96 161 1 1
    TRIM13 HIST1H4H 0 0 0 153 1 1
    TRIM13 GFOD2 0 0 81 162 1 1
    TRIM13 NPFF 0 0 173 173 1 1
    TRIM13 LRRC29 0 0 74 207 1 1
    TRIM13 RNF170 0 0 456 522 1 1
    TRIM13 GMCL1 232 0 0 231 1 1
    TRIM13 HIST2H4B 0 0 0 153 1 1
    TRIM13 ATP2A2 270 0 53 288 1 1
    TRIM13 NDEL1 0 0 440 440 1 1
    TRIM13 UBB 0 900 0 904 1 1
    TRIM13 YPEL1 0 0 59 170 1 1
    TRIM13 ENSG00000264813 0 0 296 314 1 1
    TRIM13 OPRM1 0 0 656 656 1 1
    TRIM13 USP13 0 0 96 171 1 1
    TRIM13 ALB 0 0 162 161 1 1
    TRIM13 TRIM41 0 0 193 214 1 1
    TRIM13 MME 0 0 467 467 1 1
    TRIM13 CDK5 0 0 323 333 1 2
    TRIM13 GGH 0 0 150 211 1 1
    TRIM13 SPIDR 0 0 164 163 1 1
    TRIM13 RNF123 0 0 107 243 1 1
    TRIM13 MARCH11 0 0 94 170 1 1
    TRIM13 DDX41 0 0 86 468 1 1
    TRIM13 VCPIP1 0 0 113 564 1 1
    TRIM13 FBXO9 0 0 0 151 1 1
    TRIM13 PRDM15 0 0 113 164 1 1
    TRIM13 MARCH2 0 0 108 152 1 1
    TRIM13 TPM2 0 0 61 186 1 1
    TRIM13 NANOS3 0 0 0 156 1 1
    TRIM13 MARCH4 0 0 280 296 1 1
    TRIM13 CALCA 0 0 262 262 1 1
    TRIM13 UBE3D 0 0 193 240 1 1
    TRIM13 TRAF6 270 0 158 359 1 2
    TRIM13 GGA1 0 0 66 230 1 1
    TRIM13 UBE4B 0 0 174 173 1 1
    TRIM13 DICER1 0 0 0 171 1 1
    TRIM13 PROCR 0 0 51 167 1 1
    TRIM13 TRPC6 0 0 372 372 1 1
    TRIM13 TRIM55 0 0 181 155 1 1
    TRIM13 TRIM17 0 0 499 229 1 2
    TRIM13 SLC8A2 0 0 270 270 1 1
    TRIM13 AMFR 0 0 420 432 1 1
    TRIM13 ENOX2 0 0 0 185 1 1
    TRIM13 PRRG4 0 0 128 219 1 1
    TRIM13 TRIM11 0 0 391 229 1 1
    TRIM13 TRIM38 0 0 469 236 1 1
    TRIM13 UBXN4 0 0 240 540 1 1
    TRIM13 ECE2 0 0 0 179 1 1
    TRIM13 SPRYD7 0 0 595 810 1 1
    TRIM13 BOK 0 0 61 285 1 2
    TRIM13 PUM2 0 0 0 199 1 1
    TRIM13 TRPC7 0 0 405 405 1 1
    TRIM13 SLC44A2 0 0 85 155 1 1
    TRIM13 UTP14C 0 0 0 155 1 1
    TRIM13 TBL1X 0 0 134 193 1 1
    TRIM13 TRIM31 0 0 293 175 1 1
    TRIM13 TMEM129 0 0 322 343 1 1
    TRIM13 SAR1A 0 0 90 185 1 1
    TRIM13 MID1 0 0 210 177 1 1
    TRIM13 GNRH1 0 0 166 258 1 1
    TRIM13 CPB1 0 0 282 282 1 1
    TRIM13 NMRAL1 0 0 134 152 1 1
    TRIM13 AURKA 0 0 431 443 1 2
    TRIM13 TES 0 0 125 158 1 1
    TRIM13 GPBP1L1 0 0 71 166 1 1
    TRIM13 SELL 0 0 592 599 1 1
    TRIM13 SQSTM1 486 0 873 933 1 2
    TRIM13 UFD1L 0 0 181 181 1 1
    TRIM13 MUL1 0 0 146 294 1 2
    TRIM13 NEDD4 0 0 216 241 1 2
    TRIM13 TRIM27 0 0 416 207 1 1
    TRIM13 DDOST 270 0 0 270 1 1
    TRIM13 SUMO2 0 0 127 167 1 1
    TRIM13 RNF145 0 0 113 166 1 1
    TRIM13 CACNA1C 270 0 162 443 1 1
    TRIM13 CXCR4 0 0 441 441 1 2
    TRIM13 HIST1H4F 0 0 0 153 1 1
    TRIM13 RNF138 0 0 113 355 1 1
    TRIM13 TRIM59 0 0 517 188 1 1
    TRIM13 LAP3 0 0 154 155 1 1
    TRIM13 MYLK2 0 0 102 163 1 1
    TRIM13 PIK3C3 270 0 95 336 1 2
    TRIM13 LHFP 0 0 123 215 1 1
    TRIM13 TRIM71 0 0 193 342 1 1
    TRIM13 SYVN1 98 0 337 390 1 1
    TRIM13 ST7 226 0 0 225 1 1
    TRIM13 TRIM9 0 0 256 169 1 1
    TRIM13 ZNFX1 0 0 96 175 1 1
    TRIM13 GZMM 0 0 275 286 1 1
    TRIM13 MAP1LC3B2 0 0 0 157 1 2
    TRIM13 CA2 0 0 172 172 1 1
    TRIM13 TRIM25 0 0 455 370 1 1
    TRIM13 CD7 0 0 395 394 1 1
    TRIM13 PML 0 0 420 524 1 1
    TRIM13 FKBP8 117 0 0 152 1 1
    TRIM13 HIST4H4 0 0 0 153 1 1
    TRIM13 RNF125 0 0 263 273 1 1
    TRIM13 UBE2H 0 0 0 154 1 1
    TRIM13 ARR3 0 0 129 325 1 1
    TRIM13 TRIM33 0 0 208 460 1 1
    TRIM13 GPT2 0 0 0 231 1 1
    TRIM13 MEFV 0 0 117 157 1 2
    TRIM13 HGD 0 0 147 179 1 1
    TRIM13 USP15 0 0 243 271 1 1
    TRIM13 ARHGAP1 0 0 390 395 1 1
    TRIM13 PBK 0 0 0 193 1 1
    TRIM13 L3MBTL4 0 0 123 174 1 1
    TRIM13 CPN1 0 0 150 185 1 1
    TRIM13 ZNRF4 0 0 370 370 1 1
    TRIM13 TMEM69 0 0 75 172 1 1
    TRIM13 ST13 0 0 187 194 1 2
    TRIM13 TXNL1 0 0 108 162 1 1
    TRIM13 TRIM16 0 0 306 425 1 2
    TRIM13 MDM2 270 0 260 471 1 1
    TRIM13 TP53 0 0 233 244 1 2
    TRIM13 EPS15 0 0 118 177 1 1
    TRIM13 C3orf33 0 0 165 204 1 1
    TRIM13 RPL36 0 0 0 161 1 1
    TRIM13 CUL2 0 0 73 150 1 1
    TRIM13 TRIM15 0 0 234 154 1 1
    TRIM13 ADAT2 0 0 94 253 1 1
    TRIM13 KPNA3 0 0 260 270 1 1
    TRIM13 C2orf66 0 0 260 260 1 1
    TRIM13 HSPA12B 0 0 0 207 1 1
    TRIM13 NLRC5 0 0 95 198 1 1
    TRIM13 CACNA1D 0 0 63 162 1 1
    TRIM13 RNF111 0 0 206 216 1 1
    TRIM13 UBE4A 0 0 180 179 1 1
    TRIM13 NR4A1 270 0 81 320 1 1
    TRIM13 TRIM8 0 0 405 303 1 1
    TRIM13 KIAA1841 0 0 170 189 1 1
    TRIM13 TRIM47 0 0 94 150 1 1
    TRIM13 RNF14 0 0 90 186 1 1
    TRIM13 AGO1 0 0 0 169 1 1
    TRIM13 AASDHPPT 0 0 199 199 1 1
    TRIM13 FBXL2 0 0 112 174 1 1
    TRIM13 HIST1H4K 0 0 0 153 1 1
    TRIM13 TMED4 0 0 130 263 1 1
    TRIM13 TRIM26 0 0 283 222 1 1
    TRIM13 TRIM32 0 0 391 259 1 1
    TRIM13 UBE2S 0 0 143 268 1 1
    TRIM13 SIMC1 0 0 195 195 1 1
    TRIM13 TRIM45 0 0 74 326 1 1
    TRIM13 OPRD1 0 0 235 302 1 1
    TRIM13 UBC 0 900 0 904 1 1
    TRIM13 MAP1LC3B 0 0 54 169 1 2
    TRIM13 KLHDC4 0 0 182 199 1 1
    TRIM13 DLEU7 0 0 427 583 1 1
    TRIM13 SETDB2 0 0 194 261 1 1
    TRIM13 THUMPD3 0 0 164 250 1 1
    TRIM13 UBE3B 0 0 103 215 1 1
    TRIM13 UBE2D2 270 0 95 329 1 1
    TRIM13 IFNB1 0 0 139 157 1 1
    TRIM13 IFT80 0 0 0 512 1 1
    TRIM13 TRIM39 0 0 379 192 1 1
    TRIM13 DLEU1 0 0 813 813 1 1
    TRIM13 TBC1D23 0 0 185 185 1 1
    TRIM13 CACTIN 0 0 45 178 1 1
    TRIM13 GABBR1 0 0 173 173 1 1
    TRIM13 CTDNEP1 131 0 0 150 1 1
    TRIM13 DLX5 0 0 0 522 1 1
    TRIM13 CAB39L 0 0 213 213 1 1
    TRIM13 FBXL19 0 0 0 180 1 1
    TRIM13 PAIP2 0 0 81 157 1 1
    TRIM13 BECN1 270 0 134 353 1 2
    TRIM13 PSENEN 0 0 855 855 1 1
    TRIM13 MEX3C 0 0 151 212 1 1
    TRIM13 PPM1A 0 0 95 154 1 1
    TRIM13 HIST1H4G 0 0 0 153 1 1
    TRIM13 PDYN 0 0 681 681 1 1
    TRIM13 ENSG00000257767 0 0 0 182 1 1
    TRIM13 THRB 0 0 150 181 1 1
    TRIM13 NUP155 0 0 0 162 1 1
    TRIM13 ECSIT 0 0 113 304 1 1
    TRIM13 PTGES3 0 0 54 199 1 1
    TRIM13 ARRB2 0 0 184 234 1 1
    TRIM13 RPS27A 0 900 0 904 1 1
    TRIM13 ARRB1 0 0 204 252 1 1
    TRIM13 GPX8 0 0 0 162 1 1
    TRIM13 NPLOC4 130 0 180 256 1 1
    TRIM13 ACE 0 0 336 354 1 1
    TRIM13 REN 0 0 129 203 1 1
    TRIM13 TRIM22 0 0 336 159 1 1
    TRIM13 DPEP1 0 0 190 190 1 1
    TRIM13 CEBPZ 0 0 152 151 1 1
    TRIM13 PLA2G6 0 0 0 172 1 1
    TRIM13 SLC25A16 0 0 815 815 1 1
    TRIM13 SMURF1 0 0 181 200 1 1
    TRIM13 CDH16 0 0 86 157 1 1
    TRIM13 ANPEP 0 0 155 161 1 1
    TRIM13 A1BG 0 0 55 270 1 1
    TRIM13 TICAM2 0 0 90 152 1 1
    TRIM13 TRIM14 0 0 273 303 1 1
    TRIM13 CD2 0 0 181 195 1 1
    TRIM13 ZFYVE1 273 0 177 403 1 2
    TRIM13 TRMT5 0 0 0 469 1 1
    TRIM13 HACE1 0 0 88 157 1 1
    TRIM13 TPRA1 0 0 134 267 1 1
    TRIM13 SMURF2 0 0 150 170 1 1
    TRIM13 OXT 0 0 215 215 1 1
    TRIM13 GFM1 0 0 181 202 1 1
    TRIM13 RAB11FIP2 0 0 154 174 1 1
    TRIM13 USP2 0 0 141 194 1 1
    TRIM13 UTP14A 0 0 0 155 1 1
    TRIM13 TRIM52 0 0 217 230 1 1
    TRIM13 SCAF4 0 0 134 267 1 1
    TRIM13 PDLIM2 0 0 134 188 1 1
    TRIM13 SMC4 0 0 71 309 1 1
    TRIM13 CCK 0 0 322 321 1 1
    TRIM13 USP3 0 0 140 195 1 1
    TRIM13 SUPT16H 0 0 72 304 1 1
    TRIM13 OPRK1 0 0 451 463 1 1
    TRIM13 PNOC 0 0 242 259 1 1
    TRIM13 IRF3 0 0 167 180 1 1
    TRIM13 ARG2 0 0 267 355 1 1
    TRIM13 PAFAH1B2 0 0 573 573 1 1
    TRIM13 CPE 0 0 134 212 1 1
    TRIM13 UBE3A 0 0 217 235 1 1
    TRIM13 MARCH6 0 0 396 409 1 1
    TRIM13 AKT1 270 0 182 387 1 2
    TRIM13 KATNA1 0 0 622 636 1 1
    TRIM13 DISC1 0 0 414 414 1 1
    TRIM13 GSTM1 0 0 526 537 1 1
    TRIM13 ACE2 0 0 180 266 1 1
    TRIM13 RPF2 0 0 241 240 1 1
    TRIM13 LARS 0 0 231 262 1 1
    TRIM13 IFITM1 0 0 195 195 1 1
    TRIM13 NBR1 0 0 143 243 1 2
    TRIM13 RNF4 0 0 292 307 1 1
    TRIM13 TPX2 0 0 437 437 1 1
    TRIM13 WIPI2 273 0 0 273 1 2
    TRIM13 RNF175 0 0 90 183 1 1
    TRIM13 IRF7 0 0 124 309 1 1
    TRIM13 CNR1 0 0 134 220 1 1
    TRIM13 SAG 0 0 249 319 1 1
    TRIM13 HIST1H4B 0 0 0 153 1 1
    TRIM13 GRP 0 0 233 232 1 1
    TRIM13 EHD3 0 0 74 195 1 1
    TRIM13 ADRB2 0 0 164 163 1 1
    TRIM13 TRIM65 0 0 425 199 1 1
    TRIM13 CACNA1B 0 0 123 199 1 1
    TRIM13 TRH 0 0 150 169 1 1
    TRIM13 STON2 0 0 95 203 1 1
    TRIM13 ANKRD10 0 0 163 525 1 1
    TRIM13 TRIM42 0 0 90 191 1 1
    TRIM13 HPGD 0 0 45 209 1 1
    TRIM13 FAF2 0 0 181 198 1 1
    TRIM13 TRIM62 0 0 293 300 1 1
    TRIM13 FTSJ1 0 0 101 176 1 1
    TRIM13 CASP8 0 0 145 208 1 2
    TRIM13 DCLK1 0 0 0 171 1 1
    TRIM13 KNG1 0 0 459 459 1 1
    TRIM13 ARHGEF40 0 0 134 180 1 1
    TRIM13 ZCCHC3 0 0 181 265 1 1
    TRIM13 PHF11 0 0 259 294 1 1
    TRIM13 OPRL1 0 0 321 388 1 1
    TRIM13 UBE2QL1 0 0 145 177 1 1
    TRIM13 PAPOLG 0 0 112 155 1 1
    TRIM13 TRIM39-RPP21 0 0 0 208 1 1
    TRIM13 HIST1H4E 0 0 0 153 1 1
    TRIM13 DDX58 0 0 250 354 1 1
    TRIM13 MXRA8 0 0 165 165 1 1
    TRIM13 TRIM21 0 0 391 214 1 1
    TRIM13 DDX55 0 0 0 221 1 1
    TRIM13 TPM4 0 0 0 169 1 1
    TRIM13 MAVS 0 0 210 342 1 1
    TRIM13 MAP1LC3C 0 0 65 178 1 2
    TRIM13 IFIH1 0 0 695 751 1 1
    TRIM13 TRIM16L 0 0 194 194 1 1
    TRIM13 POMC 0 0 681 681 1 1
    TRIM13 GNRH2 0 0 242 241 1 1
    TRIM13 FARP2 0 0 0 248 1 1
    TRIM13 ARL11 0 0 390 491 1 1
    TRIM13 ACAD10 0 0 0 153 1 1
    TRIM13 TRIM5 0 0 323 216 1 2
    TRIM13 PSMD4 0 0 136 166 1 1
    TRIM13 ZDHHC1 0 0 147 214 1 1
    TRIM13 TMEM173 0 0 125 272 1 1
    TRIM13 COG8 0 0 170 169 1 1
    TRIM13 TLX2 0 0 429 438 1 1
    TRIM13 MST4 0 0 74 189 1 1
    TRIM13 VRK2 0 0 0 174 1 1
    TRIM13 FKBP14 0 0 108 179 1 1
    TRIM13 TRIM3 0 0 204 158 1 1
    TRIM13 PENK 0 0 556 556 1 1
    TRIM13 VCP 270 0 455 591 1 2
    TRIM13 GTPBP4 0 0 350 364 1 1
    TRIM13 USP4 0 0 206 249 1 1
    TRIM13 PNMT 0 0 143 176 1 1
    TRIM13 GABARAPL1 0 0 74 192 1 2
    TRIM13 MXI1 0 0 49 286 1 1
    TRIM13 MS4A1 0 0 299 299 1 1
    TRIM13 OAT 0 0 206 223 1 1
    TRIM13 ZFYVE20 0 0 69 172 1 1
    TRIM13 UBE2N 0 0 154 176 1 1
    TRIM13 CD3D 0 0 205 205 1 1
    TRIM13 TMLHE 0 0 181 232 1 1
    TRIM13 KCNRG 0 0 909 909 1 1
    TRIM13 TPM1 0 0 0 169 1 1
    TRIM13 ACTB 0 0 123 157 1 1
    TRIM13 RNF5 0 0 452 465 1 1
    TRIM13 HIST1H4J 0 0 0 153 1 1
    TRIM13 MLNR 0 0 127 189 1 1
    TRIM13 IL1B 0 0 113 224 1 1
    TRIM13 TRIM66 0 0 216 416 1 1
    TRIM13 CDADC1 0 0 226 225 1 1
    TRIM13 MAP1LC3A 0 0 46 162 1 2
    TRIM13 THOP1 0 0 201 220 1 1
    TRIM13 NMT1 0 0 0 173 1 1
    TRIM13 TRIM4 0 0 392 185 1 1
    TRIM13 RHO 0 0 175 175 1 1
    TRIM13 PIDD1 0 0 92 176 1 1
    TRIM13 SEC61A1 0 0 150 160 1 1
    TRIM13 CALM1 270 0 0 291 1 1
    TRIM13 NFYB 0 0 0 162 1 1
    TRIM13 TRIM37 0 0 358 620 1 1
    TRIM13 CS 0 0 648 650 1 1
    TRIM13 SNED1 0 0 55 271 1 1
    TRIM13 RANBP2 0 0 0 164 1 1
    TRIM13 RGS4 0 0 90 554 1 1
    TRIM13 ABAT 0 0 0 165 1 1
    TRIM13 TAB3 0 0 125 181 1 2
    TRIM13 CHD7 0 0 123 170 1 1
    TRIM13 LARS2 0 0 214 261 1 1
    TRIM13 GABARAPL2 0 0 91 230 1 2
    TRIM13 JAG2 0 0 736 736 1 1
    TRIM13 KHDRBS2 0 0 84 166 1 1
    TRIM13 OGFR 0 0 134 225 1 1
    TRIM13 MYC 0 0 161 193 1 2
    TRIM13 TAB2 0 0 170 273 1 1
    TRIM13 CAPN3 0 0 106 156 1 1
    TRIM13 UBE2D1 0 0 180 201 1 1
    TRIM13 TAB1 0 0 116 163 1 1
    TRIM13 DHX33 0 0 66 256 1 1
    TRIM13 NTS 0 0 502 502 1 1
    TRIM13 CACNA1S 0 0 0 153 1 1
    TRIM13 HIST1H4L 0 0 0 153 1 1
    TRIM13 UBA1 0 0 108 153 1 1
    TRIM13 AGO4 0 0 0 169 1 1
    TRIM13 TAX1BP1 0 0 96 235 1 2
    TRIM13 UBE2K 0 0 73 189 1 1
    TRIM13 NPY 0 0 176 175 1 1
    TRIM13 DHX58 0 0 134 350 1 1
    TRIM13 EBPL 0 0 358 358 1 1
    TRIM13 STX5 0 0 60 342 1 1
    TRIM13 SCN10A 0 0 61 175 1 1
    TRIM13 TRIM24 0 0 394 487 1 1
    TRIM13 ZNF143 0 0 86 159 1 1
    TRIM13 AHSA2 0 0 150 191 1 1
    TRIM13 HIST1H4I 0 0 0 153 1 1
    TRIM13 TRIM40 0 0 265 307 1 1
    TRIM13 KIR3DL2 189 0 0 189 1 1
    TRIM13 MPPED2 0 0 0 191 1 1
    TRIM13 RCBTB1 0 0 369 387 1 1
    TRIM13 EDARADD 0 0 91 270 1 1
    TRIM13 RNF126 0 0 108 213 1 1
    TRIM13 RALBP1 0 0 54 219 1 1
    TRIM13 TRIM23 0 0 245 260 1 1
    TRIM13 PYCR1 0 0 290 290 1 1
    TRIM13 MSRB3 0 0 90 159 1 1
    TRIM13 AGO2 0 0 0 169 1 1
    Ontologies
    ID Category Term Effect Evidence PubMed
    GO:0005515 Molecular Function protein binding enables IPI
    GO:0003713 Molecular Function transcription coactivator activity enables IDA
    GO:0061630 Molecular Function ubiquitin protein ligase activity enables IBA
    GO:0061630 Molecular Function ubiquitin protein ligase activity enables TAS
    GO:0061659 Molecular Function ubiquitin-like protein ligase activity enables IDA
    GO:0004842 Molecular Function ubiquitin-protein transferase activity enables IDA
    GO:0008270 Molecular Function zinc ion binding enables IEA
    GO:0036503 Biological Process ERAD pathway involved_in IBA
    GO:0036503 Biological Process ERAD pathway involved_in IDA
    GO:0009653 Biological Process anatomical structure morphogenesis involved_in TAS
    GO:1904380 Biological Process endoplasmic reticulum mannose trimming involved_in TAS
    GO:0045087 Biological Process innate immune response involved_in IBA
    GO:0045087 Biological Process innate immune response involved_in IDA
    GO:0032897 Biological Process negative regulation of viral transcription involved_in IDA
    GO:0045893 Biological Process positive regulation of DNA-templated transcription involved_in IEA
    GO:0051092 Biological Process positive regulation of NF-kappaB transcription factor activity involved_in IMP
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in HMP
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IBA
    GO:0043123 Biological Process positive regulation of canonical NF-kappaB signal transduction involved_in IDA
    GO:0016239 Biological Process positive regulation of macroautophagy involved_in IBA
    GO:0016239 Biological Process positive regulation of macroautophagy involved_in IDA
    GO:0043161 Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process involved_in IDA
    GO:0051865 Biological Process protein autoubiquitination involved_in IDA
    GO:0044790 Biological Process suppression of viral release by host involved_in IDA
    GO:0005737 Cellular Component cytoplasm is_active_in IBA
    GO:0005737 Cellular Component cytoplasm located_in IDA
    GO:0005789 Cellular Component endoplasmic reticulum membrane located_in IDA
    GO:0005789 Cellular Component endoplasmic reticulum membrane located_in TAS
    GO:0044322 Cellular Component endoplasmic reticulum quality control compartment located_in IEA
    GO:0097038 Cellular Component perinuclear endoplasmic reticulum located_in IDA
    Pathways
    Name DB ID
    Transcripts
    Accession Version MolecularType Name NCBI Comments
    NM_213590 3 mRNA transcript variant 3 NC_000013 Reference
    NM_001007278 3 mRNA transcript variant 4 NC_000013 Reference
    NM_052811 4 mRNA transcript variant 2 NC_000013 Reference
    NM_005798 5 mRNA transcript variant 1 NC_000013 Reference