HADb is the first Human Autophagy-dedicated Database. It’s a public repository containing information about the human genes described so far as involved in autophagy.

What is autophagy?

Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy plays a key role in diverse pathologies, including infections, cancer, neurodegeneration and aging as well as in heart, liver and kidney diseases (read more). Accordingly, there has been a tremendous increase in autophagy research in the past 10 years. All these studies have increased the number of autophagy related genes and proteins reported. Therefore, the necessity emerged to develop a comprehensive database committed to keeping researchers knowledge up to date in the fast growing field of autophagy.

News

About data inside HADb

HADb provides a complete and an up-to-date list of human genes and proteins involved directly or indirectly in autophagy as described in literature.
General information, comments and genomic annotations had been used to describe genes (more detail). The display of annotations and the navigation on the genome is then possible by using an internal GBrowse or a link to Ensembl.To browse all the database entries, click here.
For proteins, HADb proposes general, structural and functional information. Thus, users can access to several kinds of properties generally used to describe a protein (family, post transcriptional modification, interaction, function, cell location, features, isoform and …). The subsection clustering of proteins presents different motifs, sites and domains that are represented on the autophagic proteins.
As we cannot display all the data, several links towards main databases are then proposed.

How to find a gene or a protein?

Go to section "Look for gene", HADb query’s interface. Search gene using symbol or synonym, chromosome location, keywords (a protein function for example) or a variety of external database accessions.

Evolution

More than being a simple autophagy repository, HADb will provide different tools for analysis, search and visualization to facilitate explorations, predictions and studies. To achieve this goal, several updates will be made.