(ATG4D) ATG4 autophagy related 4 homolog D (S. cerevisiae) [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  10352
 Official symbol  ATG4D
 Official name  ATG4 autophagy related 4 homolog D (S. cerevisiae)
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 19 (NC_000019.9) :  10654646...10664093  (+)
 Map  19p13.2
 Length  9448  nt
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Alternative name(s) and Synynom(s) top
Synonyms AUTL4; APG4D; APG4-D
Alternative name(s) aTG4 autophagy related 4 homolog D (S. cerevisiae); autophagy-related cysteine endopeptidase 4; cysteine protease involved in autophagy; AUT-like 4, cysteine endopeptidase; autophagin-4; AUT-like 4, cysteine endopeptidase (S. cerevisiae); APG4 autophagy 4 homolog D (S. cerevisiae)
External Links top
Ensembl ENSG00000130734
Entrez 84971
HGNC 20789
HPRD 07005
Comment top
Summary Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq].
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Related Articles in PubMed
Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
1  CCTGGGGACG GGGGCCGAGT AGCGCCTTCC CCGGGCCCCG TGAACCGGCT GCGGGTCGCC CTTGGGGGGC AGCGGCCGCA
81  GCCCCCCACC TGGGCCCTCG GTCCGCCCTC CCGGCGCGTC CATGAACTCA GTGTCGCCGG CCGCCGCGCA GTACCGGAGC
161  AGCAGCCCGG AGGACGCGCG CCGCCGGCCC GAGGCCCGCA GGCCGCGGGG TCCCAGAGGC CCAGACCCCA ACGGCCTGGG
241  GCCTTCCGGA GCCAGCGGCC CCGCTCTTGG CTCTCCCGGG GCTGGCCCGA GTGAGCCGGA CGAAGTGGAC AAGTTCAAGG
321  CCAAGTTCCT GACAGCCTGG AACAACGTCA AGTACGGTGA GGAGGGGGCC CGGAGATCGT GGGGGTGTCG GGGGCCGTTG
401  AGGAAAACCA GACCCCGGTC CTGCCAGTTA TCCCACCCTT GTTCCCGTCC TGAGTCACCT GTGGGTCCCC TCCCTGCCCG
481  GCCCAGGGTG GACCTGTGGC AGGTCCAATA GTGTTTTCAA GCCCCGCCCA TTCCCCTGTG TGACCTTGGG CAAGATCCTT
561  TGCTTCCTGG CGCCTCCGTT TTTGCCCCTC TCTGTAAAAT GGGTACAATA ATCAGAACTA CCTTCCTTCA TCCTGAATTG
641  ATGGTGGACA CTCCTGTAGC TGTCACTGGG GGCCCCACCT CCGACGGAAT CCCCGGAGCC ACCCCGGAGA TAGGAACTAG
721  GATCGTGCCC ATTTCACAGA TGGGGGAATG GAAGCGCTGT TGCTGTCATG CAAGTGCTTC ATCTCGCTGG GCGCTGCCCC
801  TACGTCTCCC CAGGTTGGGT GGTTAAAAGC CGGACCAGCT TTAGCAAGAT CTCCAGCATC CACCTCTGTG GCCGCCGCTA
881  CCGTTTCGAG GGCGAGGGTG AGCTGGTGGT TGGGACCAGG GCTGGGGGAG GCCTCTCCAC GCCCGCCGGA GTGTCCCTGG
961  TGGCAGCTGA CAGACCCGCT CTTGTAGGTG ACATACAGCG TTTCCAGCGG GACTTTGTGT CCCGCCTGTG GCTCACATAC
1041  CGCCGGGACT TCCCGCCCCT TCCTGGGGGC TGCCTGACCT CGGACTGTGG CTGGGGGTGC ATGTTACGCA GCGGCCAGAT
1121  GATGCTGGCA CAGGGCCTTC TGCTGCATTT CCTGCCCAGA GGTGAGCCAT AGGGGGGAAG GGGTGCACTA GGAGTACAGG
1201  GTCAACTGCC ATATCAGCAG TATTAGAATT ACTTACCAAC TAAGAGTTCA AAGTCACGTT AGAATTGTGT GTCAAGTAAG
1281  TTTTGGAGAG ATGAGAGTTG TTTATAAGAG TTTCAGCCGG GGTTGGAAAC GGTGGCTCAT GCCTGTAATC CTAGCACTTT
1361  GGGAGGCTGA GGCGGATGGA TCCCTTGCGG TCAGGAGTTC AAGACCAGCC TGGCCAATAT GATGAAACCC CATCTCTACT
1441  AAAAATACAA AAATTAGCCG GTTGTGGTGG CACACGCCTG TAATCCCAGC TACTCCCGAG GCTGAGGTGG GAGAATCTCT
1521  TGAACCCAGG AGGCGGAGGT TACAGCAAGC CAAGATCGCA CCACTGCACT CCAGCCTGGG CAACAGAGGG AGACTCTGTG
1601  TCAAAAATAA AAATAAAAAA AAGTTTCACC AGGCACGGTG GCTCATGCCT GTAATCCCAG CACTTTGGGA GGCTGAGGCT
1681  GGTGGATCAT GAGGTCAGGA GTTCAAGACC AGCCTGGCCA AGATGGTGAA ACCCCATCTC TACTAAAAAT ACAAAAATTA
1761  GCTGGGTGTG GTGGCAGGCA CCTGTAATTT GGCAAGGTAA AGCAGAGAAT TGCTTGAACC GGGGAGGCGG AGGTTGCAGT
1841  GAGCCGAGAT CCGTGCCACT GCACTCCAGC CTGGGTGGCA GAGCGAGACT CAGTCTCAAA AAAAAAAAAA GAGTTTTGGC
1921  TGGGCACTGT GCTGCATGCT TGTAATCCCA GCTACCTGGG AGGCTGAGGT GGGAAGATTG CTCGTGCCCA GGTGTTCAAG
2001  TCTGCAGTGA ACTATGATCC TGCCACTGCA CTCCAACCCG AGTGACAGAA TGAGACTCCA ACAATAACAG GTCGAGTGTG
2081  GTGGCTCATG CCTGTAATCC CAGCACATTA GGAGGCTGAG GCAGGAGGAT CGCTTGAGCA TAGGCATTCG ACACCAGCCT
2161  AGGCCACATG ACAAGGCTCC TGTCTCTACA AAAAAATTTT AAAAATTAGC TGAGTGTGGT GGCATGTGCC TGTGATCCCA
2241  ACTACTCAGG AGGCTGAGGC GGGAGAATCT GTTGAGCTCA GGATTTAGAG GCTGTAGTGA GACGTGATTG TGCCACTGCA
2321  CTCCAGTCTG GATGACAGTG AGATCCTGTC TTTATTTATT TATTTTATTT ATTATTATTA TTATTTTTTT TTTTGAGACT
2401  GAGTCTTCCT CTATCATCCT GGCTGAAGTG CAGTGGAGAG ATCTTGGCTC ACTGCAACCT CTGCCTCCCA GGTTCAAGCG
2481  ATTCTCCTGC CTCAGCCTCC TGAGTAGCTG GGATTACAGG TGCCCGCCAC CACGCTTGTC TACTTTTTGT ATATTTTTTT
2561  TTTTATCAGA GAAGGGGTTT CACCATGTTG GCCAGGCTGG TCTCGAACTC CAGGCCTCAA GTGATCCACC TGCCTTGGTC
2641  TCCCAAAGTG CTGAGATTAC AGGCATGAGC CACCGCGTCT GGCTGAGATC CTGTCTTTAA GTAACAAAAA ATAAATAAAT
2721  AAATAAGGAT AAGTATATGT TTCAGGAATA TGTAAATTCT GTTGAATTAC GGGGTTCAGG AGCATTCGCA TTGTGTGCGG
2801  TGCATGTGTA GATGGGACCT CTGCCCCCCA CACACTAGCA CTGTTTGACT ATGTGCTCCA TTCCACCAGA CTGGACATGG
2881  GCCGAGGGCA TGGGCCTGGG CCCCCCTGAG CTGTCAGGGT CAGCCTCTCC CAGCCGGTAC CATGGGCCTG CCCGCTGGAT
2961  GCCCCCACGC TGGGCCCAGG GTGCCCCTGA GCTGGAGCAG GAACGCCGGC ACCGGCAGAT TGTGTCCTGG TTCGCCGACC
3041  ACCCCCGGGC CCCCTTTGGC CTACACCGGC TGGTGGAGCT TGGGCAGAGC TCAGGCAAGA AGGCAGGTGA CTGGTATGGG
3121  CCATCGCTAG TGGCACACAT CCTCAGGTGA GGGCTGCTGC AGGGATCACG GGAGTTGCTG GGTACCCGCA GGCACTCAGG
3201  CCTTCCCTCC TGCCCCCAGG AAAGCCGTGG AGAGCTGCTC CGACGTCACC CGCCTGGTGG TGTACGTTTC TCAGGACTGC
3281  ACAGGTAAGG GGCTGGGAGC CAAGATCACA GGGGCCCCAC CCTGAGCCAG ACTCTGCCTT ACCCGATTCT TAGAGTGCAT
3361  CTTCCTCAGA GGCTGGAACA AGTTGTGGGG CAGAGGGACA CTGGGGAAGG ATGCAAGGCC TGTGCAGTGG GAGATAGTCC
3441  CTCTTCTCCG TCTCTCCCTC TGGAACAAGA AACTTCAGGG GCTTCTCCTT GAGTGATAGA ATAGAGACAT AAGGCCAGGT
3521  GTGGTGGCAC ATACTGTAGT CTCAGCTACT TGGGAGGCTG AGGTGGGAGG ATTGCTTGAA CCCAGGAGTT CGAGGTTACA
3601  GTGAGCTGTC ATTATGCCAT TGCACTCCAG CCTGGGCGAC AGAGTAGGAT CCTGTCGAAA AAAAAAAAAA AAAAAAAAAG
3681  AGGCCAGGCG CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCA AGGTGGGTGG ATCACCTGAG GTCAGGTCAC
3761  TCTGTCACCC AGGCTTCAGT GCAGAGGCAC GATCTCGGCT CACTGCAACC TCTGCCTCCT GGGTTCAAGC GATTCTCCTG
3841  CCTCAGCCTC TCAAATAGCT GGGATTACAG GCACGCACCA CCATACCAGG CTAATTTTTC TATTTTTAGT AGAGATGGGG
3921  TTTCACCATG TTGACAAGGC CGGTCTTGAA CTCCTGACCT CAGGTGATTC GCCCACTTTG GCCTCCCAAA GTGCTGGGAT
4001  TACAAGCTTG AGCCACTGTG CCCAGCCCCT GTAATTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTG
4081  AGACAGAGTC TCACTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAGTCTT GGCTCACTGC AACCTCCGCC TCCTGAGTTC
4161  GAGTGATTCT CCTGCCTCAG CCTCCCAATA GCTGGGACTA CAGGCGCGTG CCATCACGCC CAGCTAATTT TTTTTGTATT
4241  TTTAGTAGAG TTGGGGTTTC ACTGTCTTTG CCAGTATGGT CTCTCGATCT CCTGACCTCA TGATCCCCCC TCCTCGGCCT
4321  CCCAAAGTGC TGGGATTACA AGCTGGAGCC ACCGTGCCCG GCTACCTCTG TAAATTTTTT ATGCAAAATT GTAGGTGTTT
4401  GGGAAAAGAT TCGATTTTCA GAGAACCTTA TCTCCAAAAT GGGTCTAATC TACTTCTCTA GGAGCACAAA ATGGGCTTAC
4481  GTAGCTGCAA GGCAGGGGGC AGGAGAATGG GCCCAAGTAA ATGGGACTGG AGGAGGAGGG ACATACCAGG ATATTTGGTT
4561  TAGGGGCTGA GTGCCCAGTG CTCCAGCTTC TGTATTGGCA AACCGAGGCA TGGAGTCACT GAGGACCTGT CAGGCATGGG
4641  GCTGGGGAGG AGCTTGAGAG AACAGTCTCT ACCTCTCCCT TCTGTATATA CTTTTGGTCT ACATCCCAGG GCCTCAGTTG
4721  CCCACTCTGT AAAATGGGGA TGTCCACACC TGCCTGGAGG TCCTGGGATT TTCTGGGGGT GTTTGGGGGG CACTAGAATG
4801  ATGATTTTGG TTAGTGATGA CAGTGTTGCC CTCTGAGAAA TTGCACGGTT GAGGTTGAGC CCCTGGGGTT AGAGGGCTAC
4881  GCTGGGGCTT GAAGGGTGGC AAGAAGGTGA CCTGCTGCTG TCCCGTCCCT CCAGTGTACA AGGCGGATGT GGCACGCCTG
4961  GTGGCCAGGC CAGACCCCAC AGCCGAGTGG AAGTCTGTGG TCATCCTGGT GCCCGTGCGA CTGGGTGGCG AGACTCTCAA
5041  CCCCGTGTAT GTGCCCTGCG TGAAGGTAGG TTCAGCTGAA TTCTAGGACA CCTCCACCTG GGAGCCCTCC AGACTTGTTT
5121  AGTTTGTGTT AGGGCTGCTG TTTGTGCAGC CCTCATCACT TTTTTTTTTT TGAGATGGAG TTTCGCTCTT GTTGCCCAGG
5201  CTGGAGGTCA ATAACGTGAT CTCGGCTCGC TGCAACCTCC GCCTCCTGGG TTCAAGCGAT TTTCTTGCCT CAGCCTCCCA
5281  AGTAGTTAGG ATTACAGGCA TGCGCCACCA CGACCACCTA ATTTTGTACT TTTAGTAGAG ACAGGGTTTC ACCATTTTGG
5361  TCAGGCTGAT CTTGAACTCC TAACCTCAGG TCATCTGCCC ACCTCGGCCT CCCAAAGTGC TGGGATAACA GGCGTGAGCC
5441  ACCACACGGG CCATCCCTTT TTTTTTGAGA CAGAGTCTTG CTCTTTTGCC CAGGCTGGAG TGCAGTGGCA CAGTCTTGGC
5521  TCATTGCAAC CTCCGCCTCC CGAGTTCAAG CAATTCTCCT GCCTCAGTCT CCCAGGTAGC TGGGACTACA GGCGTGTGCC
5601  ACCACGCCCG GCTAACTTTT GTATTTTTAG TAGAGACGGG GTTTCGCCAT GTTGGCCAGG CTGGTTCTCA AACTCCTGAC
5681  CTCAGGTGAT CCACCCACCT CAGCCTCCCA AAGTGCTGGG ATTACAGGTG TGAGCCACCA CGCCCGGCCC ATCCCTTCTT
5761  TTTTTATACT ATGCAGCACC TGCTATGTGT GCTCCCCACT GTCCCGACTG CTGGGGATTC AGAGGGGAAC AGAATAGGCA
5841  GGAGTTCTGA GTGTGCCTGC TGGGAGCAGA CGTTCTGATG GGAGGATGCT CAGCAGTGGC TATGTAACCA AAGTAGCATC
5921  ACTGTTTGGA ATGAAGCCAG GCACAGTGGC TCAGGCCTAT AATCCCAGCA CTTTGGGAGG CCGAGGCAGG AGGATCATTT
6001  GAGACCAGTC TGGGCAACAT AGTGAGACCC CCATCTCTAC ACAATTTTTT TTGAAAATAT TCGAGTCTCA CTCTCTTGCC
6081  CACGCTGGAG TGCAGTGACA CCGTCTTGGC TCACTGCAAC CTCCGCTTCC CAGGTTCAAG CAAATTTCCT GCCTCAGCCA
6161  CCCAAGTAGC TGGGATTACA GGTGTATGCC ACCACGCCCG GCTAATTTTT GTATTTTTAG CAGAGATGGG GTTTTCCCAT
6241  GTTGGCCAGG CTGGTCTTGA ACTCCCGACC TCAGGTGATC CACCCACCTC GGTCTCCCAA AGCGTTGGGA TTACAGGCAT
6321  GAGCCACTGC ACCCAGCCTC TACACAACTT TAAAAAAACA GTAACCCAAT GAAGGGCAGA TGAGGGTAGC AGCAGAGCCT
6401  AGAAAAGCGC CTCTGCAGCC ACCAGGCAAA TGAGGAGCCA GAGGAGAAGT GCTCCAGGCA AAAGGAACAG CAAGACAGAG
6481  ACCCTGAGGC TGGAAAGTCC CCTATGTATT TGCATCCGAA TAAAAGCCAG TTTTCCCAGT GACCCACAGA GCCCGGCACT
6561  ATTTGTCCAC ACCACCTTCT TGATGTCGGG ATATCCCCCA CCTTGACCTC ATATCCTCCT CCCACACTCT GCTGCAGCCA
6641  CAGGGGCCTC CTCACCTATT TCAGACACTC CCACCTCAGG GCCTTTGCGC TTGCTGCCCC TGCTGCTTGG AGCACTCTTT
6721  CAGCAGTGAT GCATGTGGCT TTTTTTTTTT TTTTTTTTTT GAGACGGAGT CTTGCTCTGT CACTCAGGCT GGAGTGCAGT
6801  GGCATGATCT CAGCTCACTG CAAGCTCCAC CTCCTGGGTT CATGCCATTC TCCTGCCTCA GCCTCCCGAG TAGCTGGGAC
6881  TACAGGCGTC CGCCACCACT CCTGGCTAAT TTTTGTATTT TTAATGGAGA TGGGGTTTCA TTGTGTTAAT CAGGATGGTC
6961  TCGATCTCCT GACCTCGTGA TCCTCCCGCT TCGGCCTCCC AAAGTACTGA GATTATGGAC ATGAGCCACT GCTTGGCTCC
7041  TGTTTTAAAA TATTTTTTGC GTGGGGGGTT TTCCAGTGAG AACCAGAAAA CCTGAGACAA ATTCTAAAAG AGCTGTAATG
7121  TTTGACCTCT TTACTTAAAA TCACAAGGCT CCCTTCCCTC TTTTATTCTT TTCCATATAG TTATCACCTC TAACACATGA
7201  GATAAATCAT GTAATTGGCT GGGCGTGGTG GCCCACGCCT GTAATCCCAG CACTTTGGGA GGCAGGTGGA TCACCTGAGG
7281  TCAGGAGTCC AAGACCAGTC TGGCCAACAT GGTGAAACCT CGTCTCTACT AAAAATACAA AAATTAGCTG GGCGTGGTGG
7361  CGGGCGCCTG TAATCCCAGC TGCTCGGGAG GCTGAGGCAG GAGAACTGCT TGAACCCAGG AGATGGAGGT TTCGGTGAGC
7441  CAAGATCGTG CTACTGCACT CCAGCCTGTA ATCCCAGCAC TTTAGGAGGC CGAGACGGGC AGATCACCTG AGGTTAGGAG
7521  GAGTTCCAGA CCAGCCTGGC TAACATGGTG AAACCCCATT TTTACTAAAA ATACAAAAAA TTAACCCGGG TGTGGTGGCG
7601  GGTGCCTGTA ATCCCAGCTA CTTGAGAAGC TGAGGCAGGA GAATCGCTTG AACTTAGGAG GCGGAGGTTG CGGTGAGCCA
7681  ATTGGGCCAC TGCACTCCAG GCTGGGTGAC AGAGTGAGAC TCCGTCTCAA AAAAAAAAAA AAAAAAAAAA TTCATGTAAT
7761  CATCTTCCTT GTTAGTCTCT CACACTAGGA TGTCAGCTCC TGAGGGCAAG GGTTTTGTGG TCTTGATCAC TGCTGCCCTC
7841  CAGAGGCTGG GTTCTCACAG AGGAGGTGTT TGCCAAGCGT TTGTTGAGTG GCTGCCTGAC AGCACCTGCC TACCCTCCTC
7921  CCTGCAGGAA CTCCTGCGTT GCGAGCTGTG CCTGGGCATC ATGGGTGGGA AACCGCGACA CTCACTGTAC TTCATTGGCT
8001  ACCAAGGTAG GCCCACCCCC TCCTCACTCC TCCCACCCCC CACCGCACCC CCACTCACAC CTGCACCCCC TGCAGATGAC
8081  TTCCTGCTGT ACCTGGACCC TCACTACTGC CAGCCCACTG TGGATGTCAG CCAGGCCGAC TTCCCCCTGG AGGTGAGTGG
8161  GAGCCCCAGT GTGTGGTTGG GGCCATGGCG GGTGGGCAGC CCAGCCTCTG AGCCTTCCTC GTCTGTCTGC CCCAGTCCTT
8241  CCACTGCACC TCGCCCCGCA AGATGGCCTT TGCCAAGATG GACCCAAGCT GTACCGTGGG CTTCTATGCT GGAGACAGGA
8321  AGGAGTTTGA GACACTCTGC TCAGAGCTGA CCAGGGTGAG CAAGAGGAAA GCTGGAGTGG GGTGAGGGGG GCGGTTGGGC
8401  AGGGCTGGGG GTGAAAGAGG AACAGAGGCC TCGAGTCCAG CAGAGCTGGG GTGCTGCTTC CAGGCTAGGG GTCCTAACCT
8481  GGGAAATGTG AAGAATGTCC ACCCCTGAAA AGGTGGGAAC GCCAAAGCCC ACTGTTAAGG CATCATCCCT TGGAGGCAGC
8561  TGTATCCAGG GGCTCAAGTG GTGGGAACCC TCCCTGTCTC TTGGCCCTGC TGTCCGACCA GGACTCTACC CTTATGGGGG
8641  CGAGAGATGG CCACCAGCCA TTCTGGGCAC CCACCCTGTG GTCACTGGAA GGGAAACGCA GGTTTTGCAG CAAAAATCCC
8721  AGGACTGTCA GTCTTTGGCT GAGCTGGGTC ACATGCTCAT GGCTGAGCCA ATCACTGTGG CCAGGGGATG GAAGGTGCTG
8801  ATTGGCTGCT CTCTCCTGGA GAGGTGGTCC TGAGAAGCAC CTACTAAATA AACCTGGGCT AAGGAATATG GCTTGGCACT
8881  GTTTGTGGCT GACCCTGTCT CCCTCTTCCC GCCAGGTCCT CAGCTCCTCC TCAGCCACAG AGCGGTACCC CATGTTCACC
8961  CTGGCCGAGG GCCATGCTCA GGACCACAGC CTGGACGACC TCTGCTCCCA GCTCGCCCAG CCCACACTCC GGCTCCCTCG
9041  CACAGGGCGG CTCCTCAGGG CCAAACGCCC CAGCTCTGAG GACTTTGTGT TTTTATAAAG GGAGGGGATG AGGGGAAAGA
9121  TACAACACTA TTTATTTTTT TATTTATGTC ATGTCGGGTG TGGGATCTTG AGCTCTGGCA GTGATGATGG TACTTCCTGT
9201  TGTCAGCCCC TCAAGCCCAG CTGCAACCAG TCTGGGGCCA TTCAGCCAGG GACAGAGCCC ACAGAGCCCA TACACCTGTC
9281  TCCCACCAGC GGGGCCCTCC TGGCAGGGTA GGGAAGGAGG ACCCCGGGCA CCCCCCTCAG GGCCTGACTC ACGTACTGTA
9361  GTTTGCACTG GACGCCCGGG CCCTCCCTGT CCCAAAGCCC CCTTGGGGGA ACTGTGGCTG CTGGGGGCCA ATAAAGCTGT
9441  GTAACTTG
>ref|Gene_ID:84971|ATG4D|NC_000019.9:10654646...10664093 (+)
CCTGGGGACGGGGGCCGAGTAGCGCCTTCCCCGGGCCCCGTGAACCGGCTGCGGGTCGCCCTTGGGGGGCAGCGGCCGCA
GCCCCCCACCTGGGCCCTCGGTCCGCCCTCCCGGCGCGTCCATGAACTCAGTGTCGCCGGCCGCCGCGCAGTACCGGAGC
AGCAGCCCGGAGGACGCGCGCCGCCGGCCCGAGGCCCGCAGGCCGCGGGGTCCCAGAGGCCCAGACCCCAACGGCCTGGG
GCCTTCCGGAGCCAGCGGCCCCGCTCTTGGCTCTCCCGGGGCTGGCCCGAGTGAGCCGGACGAAGTGGACAAGTTCAAGG
CCAAGTTCCTGACAGCCTGGAACAACGTCAAGTACGGTGAGGAGGGGGCCCGGAGATCGTGGGGGTGTCGGGGGCCGTTG
AGGAAAACCAGACCCCGGTCCTGCCAGTTATCCCACCCTTGTTCCCGTCCTGAGTCACCTGTGGGTCCCCTCCCTGCCCG
GCCCAGGGTGGACCTGTGGCAGGTCCAATAGTGTTTTCAAGCCCCGCCCATTCCCCTGTGTGACCTTGGGCAAGATCCTT
TGCTTCCTGGCGCCTCCGTTTTTGCCCCTCTCTGTAAAATGGGTACAATAATCAGAACTACCTTCCTTCATCCTGAATTG
ATGGTGGACACTCCTGTAGCTGTCACTGGGGGCCCCACCTCCGACGGAATCCCCGGAGCCACCCCGGAGATAGGAACTAG
GATCGTGCCCATTTCACAGATGGGGGAATGGAAGCGCTGTTGCTGTCATGCAAGTGCTTCATCTCGCTGGGCGCTGCCCC
TACGTCTCCCCAGGTTGGGTGGTTAAAAGCCGGACCAGCTTTAGCAAGATCTCCAGCATCCACCTCTGTGGCCGCCGCTA
CCGTTTCGAGGGCGAGGGTGAGCTGGTGGTTGGGACCAGGGCTGGGGGAGGCCTCTCCACGCCCGCCGGAGTGTCCCTGG
TGGCAGCTGACAGACCCGCTCTTGTAGGTGACATACAGCGTTTCCAGCGGGACTTTGTGTCCCGCCTGTGGCTCACATAC
CGCCGGGACTTCCCGCCCCTTCCTGGGGGCTGCCTGACCTCGGACTGTGGCTGGGGGTGCATGTTACGCAGCGGCCAGAT
GATGCTGGCACAGGGCCTTCTGCTGCATTTCCTGCCCAGAGGTGAGCCATAGGGGGGAAGGGGTGCACTAGGAGTACAGG
GTCAACTGCCATATCAGCAGTATTAGAATTACTTACCAACTAAGAGTTCAAAGTCACGTTAGAATTGTGTGTCAAGTAAG
TTTTGGAGAGATGAGAGTTGTTTATAAGAGTTTCAGCCGGGGTTGGAAACGGTGGCTCATGCCTGTAATCCTAGCACTTT
GGGAGGCTGAGGCGGATGGATCCCTTGCGGTCAGGAGTTCAAGACCAGCCTGGCCAATATGATGAAACCCCATCTCTACT
AAAAATACAAAAATTAGCCGGTTGTGGTGGCACACGCCTGTAATCCCAGCTACTCCCGAGGCTGAGGTGGGAGAATCTCT
TGAACCCAGGAGGCGGAGGTTACAGCAAGCCAAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGGGAGACTCTGTG
TCAAAAATAAAAATAAAAAAAAGTTTCACCAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCT
GGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTA
GCTGGGTGTGGTGGCAGGCACCTGTAATTTGGCAAGGTAAAGCAGAGAATTGCTTGAACCGGGGAGGCGGAGGTTGCAGT
GAGCCGAGATCCGTGCCACTGCACTCCAGCCTGGGTGGCAGAGCGAGACTCAGTCTCAAAAAAAAAAAAAGAGTTTTGGC
TGGGCACTGTGCTGCATGCTTGTAATCCCAGCTACCTGGGAGGCTGAGGTGGGAAGATTGCTCGTGCCCAGGTGTTCAAG
TCTGCAGTGAACTATGATCCTGCCACTGCACTCCAACCCGAGTGACAGAATGAGACTCCAACAATAACAGGTCGAGTGTG
GTGGCTCATGCCTGTAATCCCAGCACATTAGGAGGCTGAGGCAGGAGGATCGCTTGAGCATAGGCATTCGACACCAGCCT
AGGCCACATGACAAGGCTCCTGTCTCTACAAAAAAATTTTAAAAATTAGCTGAGTGTGGTGGCATGTGCCTGTGATCCCA
ACTACTCAGGAGGCTGAGGCGGGAGAATCTGTTGAGCTCAGGATTTAGAGGCTGTAGTGAGACGTGATTGTGCCACTGCA
CTCCAGTCTGGATGACAGTGAGATCCTGTCTTTATTTATTTATTTTATTTATTATTATTATTATTTTTTTTTTTGAGACT
GAGTCTTCCTCTATCATCCTGGCTGAAGTGCAGTGGAGAGATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCG
ATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCCCGCCACCACGCTTGTCTACTTTTTGTATATTTTTTT
TTTTATCAGAGAAGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCAGGCCTCAAGTGATCCACCTGCCTTGGTC
TCCCAAAGTGCTGAGATTACAGGCATGAGCCACCGCGTCTGGCTGAGATCCTGTCTTTAAGTAACAAAAAATAAATAAAT
AAATAAGGATAAGTATATGTTTCAGGAATATGTAAATTCTGTTGAATTACGGGGTTCAGGAGCATTCGCATTGTGTGCGG
TGCATGTGTAGATGGGACCTCTGCCCCCCACACACTAGCACTGTTTGACTATGTGCTCCATTCCACCAGACTGGACATGG
GCCGAGGGCATGGGCCTGGGCCCCCCTGAGCTGTCAGGGTCAGCCTCTCCCAGCCGGTACCATGGGCCTGCCCGCTGGAT
GCCCCCACGCTGGGCCCAGGGTGCCCCTGAGCTGGAGCAGGAACGCCGGCACCGGCAGATTGTGTCCTGGTTCGCCGACC
ACCCCCGGGCCCCCTTTGGCCTACACCGGCTGGTGGAGCTTGGGCAGAGCTCAGGCAAGAAGGCAGGTGACTGGTATGGG
CCATCGCTAGTGGCACACATCCTCAGGTGAGGGCTGCTGCAGGGATCACGGGAGTTGCTGGGTACCCGCAGGCACTCAGG
CCTTCCCTCCTGCCCCCAGGAAAGCCGTGGAGAGCTGCTCCGACGTCACCCGCCTGGTGGTGTACGTTTCTCAGGACTGC
ACAGGTAAGGGGCTGGGAGCCAAGATCACAGGGGCCCCACCCTGAGCCAGACTCTGCCTTACCCGATTCTTAGAGTGCAT
CTTCCTCAGAGGCTGGAACAAGTTGTGGGGCAGAGGGACACTGGGGAAGGATGCAAGGCCTGTGCAGTGGGAGATAGTCC
CTCTTCTCCGTCTCTCCCTCTGGAACAAGAAACTTCAGGGGCTTCTCCTTGAGTGATAGAATAGAGACATAAGGCCAGGT
GTGGTGGCACATACTGTAGTCTCAGCTACTTGGGAGGCTGAGGTGGGAGGATTGCTTGAACCCAGGAGTTCGAGGTTACA
GTGAGCTGTCATTATGCCATTGCACTCCAGCCTGGGCGACAGAGTAGGATCCTGTCGAAAAAAAAAAAAAAAAAAAAAAG
AGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGTCAC
TCTGTCACCCAGGCTTCAGTGCAGAGGCACGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTG
CCTCAGCCTCTCAAATAGCTGGGATTACAGGCACGCACCACCATACCAGGCTAATTTTTCTATTTTTAGTAGAGATGGGG
TTTCACCATGTTGACAAGGCCGGTCTTGAACTCCTGACCTCAGGTGATTCGCCCACTTTGGCCTCCCAAAGTGCTGGGAT
TACAAGCTTGAGCCACTGTGCCCAGCCCCTGTAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTG
AGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAGTCTTGGCTCACTGCAACCTCCGCCTCCTGAGTTC
GAGTGATTCTCCTGCCTCAGCCTCCCAATAGCTGGGACTACAGGCGCGTGCCATCACGCCCAGCTAATTTTTTTTGTATT
TTTAGTAGAGTTGGGGTTTCACTGTCTTTGCCAGTATGGTCTCTCGATCTCCTGACCTCATGATCCCCCCTCCTCGGCCT
CCCAAAGTGCTGGGATTACAAGCTGGAGCCACCGTGCCCGGCTACCTCTGTAAATTTTTTATGCAAAATTGTAGGTGTTT
GGGAAAAGATTCGATTTTCAGAGAACCTTATCTCCAAAATGGGTCTAATCTACTTCTCTAGGAGCACAAAATGGGCTTAC
GTAGCTGCAAGGCAGGGGGCAGGAGAATGGGCCCAAGTAAATGGGACTGGAGGAGGAGGGACATACCAGGATATTTGGTT
TAGGGGCTGAGTGCCCAGTGCTCCAGCTTCTGTATTGGCAAACCGAGGCATGGAGTCACTGAGGACCTGTCAGGCATGGG
GCTGGGGAGGAGCTTGAGAGAACAGTCTCTACCTCTCCCTTCTGTATATACTTTTGGTCTACATCCCAGGGCCTCAGTTG
CCCACTCTGTAAAATGGGGATGTCCACACCTGCCTGGAGGTCCTGGGATTTTCTGGGGGTGTTTGGGGGGCACTAGAATG
ATGATTTTGGTTAGTGATGACAGTGTTGCCCTCTGAGAAATTGCACGGTTGAGGTTGAGCCCCTGGGGTTAGAGGGCTAC
GCTGGGGCTTGAAGGGTGGCAAGAAGGTGACCTGCTGCTGTCCCGTCCCTCCAGTGTACAAGGCGGATGTGGCACGCCTG
GTGGCCAGGCCAGACCCCACAGCCGAGTGGAAGTCTGTGGTCATCCTGGTGCCCGTGCGACTGGGTGGCGAGACTCTCAA
CCCCGTGTATGTGCCCTGCGTGAAGGTAGGTTCAGCTGAATTCTAGGACACCTCCACCTGGGAGCCCTCCAGACTTGTTT
AGTTTGTGTTAGGGCTGCTGTTTGTGCAGCCCTCATCACTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGG
CTGGAGGTCAATAACGTGATCTCGGCTCGCTGCAACCTCCGCCTCCTGGGTTCAAGCGATTTTCTTGCCTCAGCCTCCCA
AGTAGTTAGGATTACAGGCATGCGCCACCACGACCACCTAATTTTGTACTTTTAGTAGAGACAGGGTTTCACCATTTTGG
TCAGGCTGATCTTGAACTCCTAACCTCAGGTCATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATAACAGGCGTGAGCC
ACCACACGGGCCATCCCTTTTTTTTTGAGACAGAGTCTTGCTCTTTTGCCCAGGCTGGAGTGCAGTGGCACAGTCTTGGC
TCATTGCAACCTCCGCCTCCCGAGTTCAAGCAATTCTCCTGCCTCAGTCTCCCAGGTAGCTGGGACTACAGGCGTGTGCC
ACCACGCCCGGCTAACTTTTGTATTTTTAGTAGAGACGGGGTTTCGCCATGTTGGCCAGGCTGGTTCTCAAACTCCTGAC
CTCAGGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCCATCCCTTCTT
TTTTTATACTATGCAGCACCTGCTATGTGTGCTCCCCACTGTCCCGACTGCTGGGGATTCAGAGGGGAACAGAATAGGCA
GGAGTTCTGAGTGTGCCTGCTGGGAGCAGACGTTCTGATGGGAGGATGCTCAGCAGTGGCTATGTAACCAAAGTAGCATC
ACTGTTTGGAATGAAGCCAGGCACAGTGGCTCAGGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCAGGAGGATCATTT
GAGACCAGTCTGGGCAACATAGTGAGACCCCCATCTCTACACAATTTTTTTTGAAAATATTCGAGTCTCACTCTCTTGCC
CACGCTGGAGTGCAGTGACACCGTCTTGGCTCACTGCAACCTCCGCTTCCCAGGTTCAAGCAAATTTCCTGCCTCAGCCA
CCCAAGTAGCTGGGATTACAGGTGTATGCCACCACGCCCGGCTAATTTTTGTATTTTTAGCAGAGATGGGGTTTTCCCAT
GTTGGCCAGGCTGGTCTTGAACTCCCGACCTCAGGTGATCCACCCACCTCGGTCTCCCAAAGCGTTGGGATTACAGGCAT
GAGCCACTGCACCCAGCCTCTACACAACTTTAAAAAAACAGTAACCCAATGAAGGGCAGATGAGGGTAGCAGCAGAGCCT
AGAAAAGCGCCTCTGCAGCCACCAGGCAAATGAGGAGCCAGAGGAGAAGTGCTCCAGGCAAAAGGAACAGCAAGACAGAG
ACCCTGAGGCTGGAAAGTCCCCTATGTATTTGCATCCGAATAAAAGCCAGTTTTCCCAGTGACCCACAGAGCCCGGCACT
ATTTGTCCACACCACCTTCTTGATGTCGGGATATCCCCCACCTTGACCTCATATCCTCCTCCCACACTCTGCTGCAGCCA
CAGGGGCCTCCTCACCTATTTCAGACACTCCCACCTCAGGGCCTTTGCGCTTGCTGCCCCTGCTGCTTGGAGCACTCTTT
CAGCAGTGATGCATGTGGCTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCACTCAGGCTGGAGTGCAGT
GGCATGATCTCAGCTCACTGCAAGCTCCACCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGAC
TACAGGCGTCCGCCACCACTCCTGGCTAATTTTTGTATTTTTAATGGAGATGGGGTTTCATTGTGTTAATCAGGATGGTC
TCGATCTCCTGACCTCGTGATCCTCCCGCTTCGGCCTCCCAAAGTACTGAGATTATGGACATGAGCCACTGCTTGGCTCC
TGTTTTAAAATATTTTTTGCGTGGGGGGTTTTCCAGTGAGAACCAGAAAACCTGAGACAAATTCTAAAAGAGCTGTAATG
TTTGACCTCTTTACTTAAAATCACAAGGCTCCCTTCCCTCTTTTATTCTTTTCCATATAGTTATCACCTCTAACACATGA
GATAAATCATGTAATTGGCTGGGCGTGGTGGCCCACGCCTGTAATCCCAGCACTTTGGGAGGCAGGTGGATCACCTGAGG
TCAGGAGTCCAAGACCAGTCTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGG
CGGGCGCCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAACTGCTTGAACCCAGGAGATGGAGGTTTCGGTGAGC
CAAGATCGTGCTACTGCACTCCAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGACGGGCAGATCACCTGAGGTTAGGAG
GAGTTCCAGACCAGCCTGGCTAACATGGTGAAACCCCATTTTTACTAAAAATACAAAAAATTAACCCGGGTGTGGTGGCG
GGTGCCTGTAATCCCAGCTACTTGAGAAGCTGAGGCAGGAGAATCGCTTGAACTTAGGAGGCGGAGGTTGCGGTGAGCCA
ATTGGGCCACTGCACTCCAGGCTGGGTGACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAATTCATGTAAT
CATCTTCCTTGTTAGTCTCTCACACTAGGATGTCAGCTCCTGAGGGCAAGGGTTTTGTGGTCTTGATCACTGCTGCCCTC
CAGAGGCTGGGTTCTCACAGAGGAGGTGTTTGCCAAGCGTTTGTTGAGTGGCTGCCTGACAGCACCTGCCTACCCTCCTC
CCTGCAGGAACTCCTGCGTTGCGAGCTGTGCCTGGGCATCATGGGTGGGAAACCGCGACACTCACTGTACTTCATTGGCT
ACCAAGGTAGGCCCACCCCCTCCTCACTCCTCCCACCCCCCACCGCACCCCCACTCACACCTGCACCCCCTGCAGATGAC
TTCCTGCTGTACCTGGACCCTCACTACTGCCAGCCCACTGTGGATGTCAGCCAGGCCGACTTCCCCCTGGAGGTGAGTGG
GAGCCCCAGTGTGTGGTTGGGGCCATGGCGGGTGGGCAGCCCAGCCTCTGAGCCTTCCTCGTCTGTCTGCCCCAGTCCTT
CCACTGCACCTCGCCCCGCAAGATGGCCTTTGCCAAGATGGACCCAAGCTGTACCGTGGGCTTCTATGCTGGAGACAGGA
AGGAGTTTGAGACACTCTGCTCAGAGCTGACCAGGGTGAGCAAGAGGAAAGCTGGAGTGGGGTGAGGGGGGCGGTTGGGC
AGGGCTGGGGGTGAAAGAGGAACAGAGGCCTCGAGTCCAGCAGAGCTGGGGTGCTGCTTCCAGGCTAGGGGTCCTAACCT
GGGAAATGTGAAGAATGTCCACCCCTGAAAAGGTGGGAACGCCAAAGCCCACTGTTAAGGCATCATCCCTTGGAGGCAGC
TGTATCCAGGGGCTCAAGTGGTGGGAACCCTCCCTGTCTCTTGGCCCTGCTGTCCGACCAGGACTCTACCCTTATGGGGG
CGAGAGATGGCCACCAGCCATTCTGGGCACCCACCCTGTGGTCACTGGAAGGGAAACGCAGGTTTTGCAGCAAAAATCCC
AGGACTGTCAGTCTTTGGCTGAGCTGGGTCACATGCTCATGGCTGAGCCAATCACTGTGGCCAGGGGATGGAAGGTGCTG
ATTGGCTGCTCTCTCCTGGAGAGGTGGTCCTGAGAAGCACCTACTAAATAAACCTGGGCTAAGGAATATGGCTTGGCACT
GTTTGTGGCTGACCCTGTCTCCCTCTTCCCGCCAGGTCCTCAGCTCCTCCTCAGCCACAGAGCGGTACCCCATGTTCACC
CTGGCCGAGGGCCATGCTCAGGACCACAGCCTGGACGACCTCTGCTCCCAGCTCGCCCAGCCCACACTCCGGCTCCCTCG
CACAGGGCGGCTCCTCAGGGCCAAACGCCCCAGCTCTGAGGACTTTGTGTTTTTATAAAGGGAGGGGATGAGGGGAAAGA
TACAACACTATTTATTTTTTTATTTATGTCATGTCGGGTGTGGGATCTTGAGCTCTGGCAGTGATGATGGTACTTCCTGT
TGTCAGCCCCTCAAGCCCAGCTGCAACCAGTCTGGGGCCATTCAGCCAGGGACAGAGCCCACAGAGCCCATACACCTGTC
TCCCACCAGCGGGGCCCTCCTGGCAGGGTAGGGAAGGAGGACCCCGGGCACCCCCCTCAGGGCCTGACTCACGTACTGTA
GTTTGCACTGGACGCCCGGGCCCTCCCTGTCCCAAAGCCCCCTTGGGGGAACTGTGGCTGCTGGGGGCCAATAAAGCTGT
GTAACTTG