| (CCR2) chemokine (C-C motif) receptor 2 [Homo sapiens] |
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Gene
Transcript(s)
Exon(s)
Protein(s)
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Accession
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2340
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Official symbol
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CCR2
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Official name
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chemokine (C-C motif) receptor 2
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Gene type
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gene with protein product
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Organism
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Homo sapiens
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Location
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Chromosome 3 (NC_000003.11) : 46395234...46402412 (+)
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Map
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3p21
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Length
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7179 nt
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NM_001123041.2
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CCR2, mRNA isoform A
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NM_001123396.1
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CCR2, mRNA isoform B
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Accession
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Name
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Organism
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Length
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P41597
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C-C chemokine receptor type 2
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Homo sapiens
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374 aa
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Q4VBL2
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Chemokine (C-C motif) receptor 2 [submitted name]
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Homo sapiens
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360 aa
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| Synonyms |
MGC168006; MGC111760; MGC103828; CKR2B; CKR2A; CCR2B; CCR2A; MCP-1-R; FLJ78302; CMKBR2; CKR2; CD192; CC-CKR-2
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| Alternative name(s) |
MCP-1 receptor; monocyte chemotactic protein 1 receptor; monocyte chemoattractant protein 1 receptor
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| Summary |
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq].
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Related Articles in PubMed
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Go to ensembl 
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| 1 |
CTTTATTCTC |
TGGAACATGA |
AACATTCTGT |
TGTGCTCATA |
TCATGCAAAT |
TATCACTAGT |
AGGAGAGCAG |
AGAGTGGAAA |
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| 81 |
TGTTCCAGGT |
ATAAAGACCC |
ACAAGATAAA |
GAAGCTCAGA |
GTCGTTAGAA |
ACAGGAGCAG |
ATGTACAGGG |
TTTGCCTGAC |
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| 161 |
TCACACTCAA |
GGTTGCATAA |
GCAAGATTTC |
AAAATTAATC |
CTATTCTGGA |
GACCTCAACC |
CAATGTACAA |
TGTTCCTGAC |
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| 241 |
TGGAAAAGAA |
GAACTATATT |
TTTCTGATTT |
TTTTTTTCAA |
ATCTTTACCA |
TTAGTTGCCC |
TGTATCTCCG |
CCTTCACTTT |
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| 321 |
CTGCAGGAAA |
CTTTATTTCC |
TACTTCTGCA |
TGCCAAGTTT |
CTACCTCTAG |
ATCTGTTTGG |
TTCAGTTGCT |
GAGAAGCCTG |
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| 401 |
ACATACCAGG |
ACTGCCTGAG |
ACAAGCCACA |
AGCTGGTGAG |
TTGTAGGCAT |
TTTTTCCATT |
ACTTTCTGAT |
TCATAGGCTC |
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| 481 |
AACGCACCTC |
AAAGCTGGAA |
ATGCCGGGTC |
TGGGTACACC |
CTGGGGAACT |
GCAAAGCCTG |
CACACTTGGG |
GGGAATGATC |
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| 561 |
AAGATGAGAG |
GCAGGGGTGG |
GGATGGCATG |
TGCACCAGGA |
GATGTTAGAG |
AAACCCTGAG |
GAAGAGCAGC |
GTGCAGCAGG |
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| 641 |
TGATGGGGGA |
GAGTGGGCAG |
CAAGCGAGGC |
CAGGACAGCC |
ACTCTGCTCA |
GTCACCAGTC |
CACACACCCA |
GGGGCTCACT |
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| 721 |
CTGCCCCTCT |
GAGCACCCAA |
GGACGTTAAA |
GAGCTGGAAC |
TGTTAGTCTA |
AATATAGGAC |
CATCCAAGCT |
CTGAACCAAA |
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| 801 |
ATGTGTCCCT |
TGCCTCAACT |
CAGGAGATCC |
ACAGAGGCAG |
AAGTAAGGAA |
TTTATTTTCT |
GAAAGATAGA |
TTTCTATCAG |
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| 881 |
TTCTGGGTGA |
CATGTTCTGA |
CACTTGAAAT |
GACACCTAGG |
ACAGCACATT |
TCAGGCATCT |
TGCTCATTGT |
TCACTGTAGT |
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| 961 |
AGAAGCTACA |
TGCTAGCCAG |
TTGTAAAAAT |
GAAATTAAGT |
AATGTGTGCA |
CAGCATTTAA |
CATAGCATCT |
GAGCTTCAGG |
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| 1041 |
AGCACTCAAT |
TAATGACCAC |
AGTTGTGATT |
CTTTAGGCAG |
ATGCATTTTT |
TTCCAACTTT |
GATCAGAGGT |
CTTATTTAGC |
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| 1121 |
TTCTCCAGAT |
TTCAAGAATC |
TGGCTCAGTG |
ATATGAAATA |
CAAGACTTGT |
GAAAAGTGTC |
AATTGCAAGA |
GAAATGGAAG |
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| 1201 |
GATAAAGTAT |
ACAGGTGGGT |
GGAAAAGAAA |
TTCACAGTCA |
CTGCCAGAAA |
AAAAATTCTT |
GAGAATCAAG |
TCCTGATGAT |
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| 1281 |
GTTAGGGCTT |
ATAGTTCTTA |
TTATAAAGAG |
TTTTATGTAC |
TCATTCAGTG |
AACATTTATT |
GGTGCCTCCT |
TTAGCCAGGT |
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| 1361 |
ACTATCATAA |
GAGCTGAAAA |
TAGAAGCATA |
ATCCAGTCCT |
TGATCTTGAG |
GAACATGCTG |
TGTGTAGCAG |
ATAACATAAT |
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| 1441 |
AAGTGCTTAT |
CTAGATGCAT |
GCAGTGTTAT |
GTGATAAGAG |
TAATATGACA |
GAGGATACAG |
ATTAGGCTTC |
ACAGAGAAGG |
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| 1521 |
GGGATTTGAG |
CAGGAGGTAT |
TGAAGGGTGA |
ATAGAAGCTC |
ACCAATCATT |
TTGGGCAGAG |
GGGCAAGGAC |
CTGCAAAACC |
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| 1601 |
ACTGAAGCAT |
GAAGGAAATG |
GTGAGTTTAG |
GGAAAATGAA |
GAGAAGATGG |
CTGTGACTGA |
AGCACAGGAT |
TTGGGATTGG |
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| 1681 |
AGAAGGGACT |
GGAGGTGAGG |
CTGAAAAGAG |
GCAAACTCAG |
AAAAGATGTT |
GTGCTGGGCA |
GTCTGGACAT |
TATCTTTGAA |
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| 1761 |
GCCCACCACA |
TATAAGTCAT |
AGGGCTACTG |
GAGGTTTTAA |
GCTAAGAGTG |
ACTATTCAAT |
TTCAACTTAA |
GAGAAGATAG |
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| 1841 |
GTTGAGAGGG |
AACATGGCTT |
GAGATGAGCC |
ATGAGCAAAG |
GAAAGACTAC |
AACAAAGCCA |
GGAGTGAGGA |
GTGTGTGAAG |
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| 1921 |
CAAGAAAGTG |
ACAGTTGAAA |
GCAGTGCAGA |
GGGGATGAAT |
CTGAGAGGCA |
TCTATGAGGT |
GGAACTCAAA |
TGACATGATA |
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| 2001 |
ATAATACAGG |
GCATTTCTCT |
GTGTCAGATG |
CTGTCCTAAG |
TCCTTACTCC |
ATTGATCTTC |
ACAGCAACTC |
AGCATAGTTA |
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| 2081 |
ATATTTTATG |
CATAAAGAAA |
TCGGCACTTG |
AAGGAGTAAT |
TGGCCCCAGA |
TTACACTGCC |
TATAAGGATT |
CAAATCCAGG |
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| 2161 |
TTTGTTTGGC |
TCCAAAAACT |
GGCTCCTAAT |
TTTCAGAAGG |
AGAAGCAACC |
CAGGGCAATG |
CCCAATTTTG |
CTTCTTAGGC |
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| 2241 |
AATGGAGGAA |
TCCACAATCG |
GAAGGAGTTT |
TCAGCAGTGC |
CCCATTTGGG |
GTGGGTTGAA |
TTTGAGGTCC |
CTGCATGATA |
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| 2321 |
CCCACTTTGC |
TCACTTCAGT |
GCCTAAAACT |
GAGTATGGTT |
CATAGTAGGT |
GTTCAATAAG |
TGTTGATGCA |
GTGAATACAT |
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| 2401 |
GCATGGGGAG |
ATATGCATCA |
GGCAATGGGA |
AATTCAACTC |
TAAGGCTTAG |
GGGAAAGCTG |
GAGCTTGAAG |
ACAGAGCTTT |
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| 2481 |
AGAAAACAGT |
AGCATAGAAG |
GGAGTAGGAA |
CCATGAGTTT |
AGACAATACA |
ATTCAGGAAG |
AACTTTGTAG |
CAAGGATAAA |
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| 2561 |
GAGGCAAAAA |
ATTAAAGAGG |
TGAGAGCTAA |
GTGTGGTGCC |
TGGGGAATCT |
TAAGGTGTGG |
GCACGGGGAG |
GAGATGCCAG |
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| 2641 |
CAAAGAACAT |
GAATAAAAAG |
CGGTAGCACA |
GCCCCTCCCA |
TCTGGAAGCC |
AAAAAGAATT |
GTAAATGGAG |
GAAGTTAGCA |
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| 2721 |
GAAGGATCAA |
ATACTTGAAG |
AGGGTGGAAT |
TGGAATAAAA |
CCAGGGCATT |
TGAAAAATTG |
GGTTGTCACT |
GCAATCTTAA |
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| 2801 |
CAAGAGAAGT |
TTTGGCAGGA |
TGATGGAGGC |
AGAAAGCTGA |
GAGAATCATC |
AGTTAGAACG |
TTTTTGACTT |
CAGAGAACAG |
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| 2881 |
AAAATGCAGT |
TCATAATGGC |
TTTAAAACAG |
GGGCTTGTTT |
TTCTCCCAGC |
AATTTGAGAG |
GCCAAGGCGG |
GTGCATCAGG |
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| 2961 |
AGGTCAAGAG |
ACCGAGACCA |
TCCTGGCCAA |
CATGGTGAAT |
CCCCATCTCT |
ACTAAAAATA |
CAAAAATTAG |
CGGGGCATGG |
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| 3041 |
TGGTGCACGC |
CTATAGTCCC |
ATCTACTCAG |
GAGGCTGAGG |
CAGGAGAATC |
ACTTGAACCC |
AGGAGGTGGA |
GGTTGCAGTG |
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| 3121 |
AGCTGAGATC |
ATGGCCACTG |
CACTATAGCC |
TGGAGACACA |
GCGAGACTCC |
GTCTCCAAAA |
AAAAAAAAAA |
AAGAAGGCAG |
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| 3201 |
AAGGTGAATA |
GTTCAAGGGT |
GGGTTTAGGA |
CTCAGTGATA |
ATAGGATTCT |
GCCTGGCTTC |
TCATGGTTCT |
CTAGGTCTTC |
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| 3281 |
CATTCATGGC |
ACCATGCCCT |
CACTAGGCAT |
GCTGCCAGAG |
CAGGAGGGGC |
AGGTGGAGGG |
TTCTCTTGTG |
TCTGTCTTAT |
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| 3361 |
CAGGGAAGAA |
GAGCTTTCTC |
AGAAGCCCCC |
AGCAGACTCC |
CTTTTCATAT |
TATGGTCCAG |
CAATGAGTCA |
CAGACCTATG |
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| 3441 |
CACCACCTGC |
AAAGGAGCCA |
GAGAAAACAA |
ACGCCCAGCG |
CTTTTAGCCT |
GAAAATGAGA |
ATCTGGTTTG |
CTGGGGAAGA |
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| 3521 |
TAAAGGGTGT |
CGGAAAATGG |
CTGTTGGGTA |
AATCATTGAT |
GTCTGCCACT |
AGGAATGAAA |
GGCAAATCAG |
GAACTGGCAC |
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| 3601 |
ACATGCTTTC |
AGGGAGATGG |
CTGCAAGGGA |
GAGGGCAAAG |
ACTGGGAAGT |
TGCTTATGTG |
GTGCCAGACT |
ATTTGGAAGA |
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| 3681 |
TCATGGATTG |
CGGTGTTTGT |
GTTGTGTGGT |
CATCATTTTG |
TTCTTTGTTT |
ACAGAACAGA |
GAAAGTGGAT |
TGAACAAGGA |
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| 3761 |
CGCATTTCCC |
CAGTACATCC |
ACAACATGCT |
GTCCACATCT |
CGTTCTCGGT |
TTATCAGAAA |
TACCAACGAG |
AGCGGTGAAG |
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| 3841 |
AAGTCACCAC |
CTTTTTTGAT |
TATGATTACG |
GTGCTCCCTG |
TCATAAATTT |
GACGTGAAGC |
AAATTGGGGC |
CCAACTCCTG |
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| 3921 |
CCTCCGCTCT |
ACTCGCTGGT |
GTTCATCTTT |
GGTTTTGTGG |
GCAACATGCT |
GGTCGTCCTC |
ATCTTAATAA |
ACTGCAAAAA |
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| 4001 |
GCTGAAGTGC |
TTGACTGACA |
TTTACCTGCT |
CAACCTGGCC |
ATCTCTGATC |
TGCTTTTTCT |
TATTACTCTC |
CCATTGTGGG |
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| 4081 |
CTCACTCTGC |
TGCAAATGAG |
TGGGTCTTTG |
GGAATGCAAT |
GTGCAAATTA |
TTCACAGGGC |
TGTATCACAT |
CGGTTATTTT |
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| 4161 |
GGCGGAATCT |
TCTTCATCAT |
CCTCCTGACA |
ATCGATAGAT |
ACCTGGCTAT |
TGTCCATGCT |
GTGTTTGCTT |
TAAAAGCCAG |
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| 4241 |
GACGGTCACC |
TTTGGGGTGG |
TGACAAGTGT |
GATCACCTGG |
TTGGTGGCTG |
TGTTTGCTTC |
TGTCCCAGGA |
ATCATCTTTA |
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| 4321 |
CTAAATGCCA |
GAAAGAAGAT |
TCTGTTTATG |
TCTGTGGCCC |
TTATTTTCCA |
CGAGGATGGA |
ATAATTTCCA |
CACAATAATG |
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| 4401 |
AGGAACATTT |
TGGGGCTGGT |
CCTGCCGCTG |
CTCATCATGG |
TCATCTGCTA |
CTCGGGAATC |
CTGAAAACCC |
TGCTTCGGTG |
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| 4481 |
TCGAAACGAG |
AAGAAGAGGC |
ATAGGGCAGT |
GAGAGTCATC |
TTCACCATCA |
TGATTGTTTA |
CTTTCTCTTC |
TGGACTCCCT |
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| 4561 |
ATAATATTGT |
CATTCTCCTG |
AACACCTTCC |
AGGAATTCTT |
CGGCCTGAGT |
AACTGTGAAA |
GCACCAGTCA |
ACTGGACCAA |
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| 4641 |
GCCACGCAGG |
TGACAGAGAC |
TCTTGGGATG |
ACTCACTGCT |
GCATCAATCC |
CATCATCTAT |
GCCTTCGTTG |
GGGAGAAGTT |
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| 4721 |
CAGAAGGTAT |
CTCTCGGTGT |
TCTTCCGAAA |
GCACATCACC |
AAGCGCTTCT |
GCAAACAATG |
TCCAGTTTTC |
TACAGGGAGA |
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| 4801 |
CAGTGGATGG |
AGTGACTTCA |
ACAAACACGC |
CTTCCACTGG |
GGAGCAGGAA |
GTCTCGGCTG |
GTTTATAAAA |
CGAGGAGCAG |
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| 4881 |
TTTGATTGTT |
GTTTATAAAG |
GGAGATAACA |
ATCTGTATAT |
AACAACAAAC |
TTCAAGGGTT |
TGTTGAACAA |
TAGAAACCTG |
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| 4961 |
TAAAGCAGGT |
GCCCAGGAAC |
CTCAGGGCTG |
TGTGTACTAA |
TACAGACTAT |
GTCACCCAAT |
GCATATCCAA |
CATGTGCTCA |
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| 5041 |
GGGAATAATC |
CAGAAAAACT |
GTGGGTAGAG |
ACTTTGACTC |
TCCAGAAAGC |
TCATCTCAGC |
TCCTGAAAAA |
TGCCTCATTA |
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| 5121 |
CCTTGTGCTA |
ATCCTCTTTT |
TCTAGTCTTC |
ATAATTTCTT |
CACTCAATCT |
CTGATTCTGT |
CAATGTCTTG |
AAATCAAGGG |
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| 5201 |
CCAGCTGGAG |
GTGAAGAAGA |
GAATGTGACA |
GGCACAGATG |
AATGGGAGTG |
AGGGATAGTG |
GGGTCAGGGC |
TGAGAGGAGA |
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| 5281 |
AGGAGGGAGA |
CATGAGCATG |
GCTGAGCCTG |
GACAAAGACA |
AAGGTGAGCA |
AAGGGCTCAC |
GCATTCAGCC |
AGGAGATGAT |
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| 5361 |
ACTGGTCCTT |
AGCCCCATCT |
GCCACGTGTA |
TTTAACCTTG |
AAGGGTTCAC |
CAGGTCAGGG |
AGAGTTTGGG |
AACTGCAATA |
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| 5441 |
ACCTGGGAGT |
TTTGGTGGAG |
TCCGATGATT |
CTCTTTTGCA |
TAAGTGCATG |
ACATATTTTT |
GCTTTATTAC |
AGTTTATCTA |
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| 5521 |
TGGCACCCAT |
GCACCTTACA |
TTTGAAATCT |
ATGAAATATC |
ATGCTCCATT |
GTTCAGATGC |
TTCTTAGGCC |
ACATCCCCCT |
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| 5601 |
GTCTAAAAAT |
TCAGAAAATT |
TTTGTTTATA |
AAAGATGCAT |
TATCTATGAT |
ATGCTAATAT |
ATGTATATGC |
AATATATATA |
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| 5681 |
GGCTCTTGCT |
TGATCTCTCC |
AGGAGGTAGT |
GATTATGAGA |
AGGGGGTGGA |
GAATGATGAG |
TTCCTTCACC |
AGGAGCAAAG |
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| 5761 |
GACGGGGATC |
GTGTGGAACC |
ACTGCAGAAC |
TATTTCCGAA |
ATCAACTAAG |
TGGAGAGAGC |
CAGGAAGGCT |
GCATCAGAAC |
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| 5841 |
CCAGTAAAGC |
TTCTTGTCTG |
GATCTGAGCT |
GGTTTGTTTT |
GTGCTTGCTT |
TTCCCTGCCT |
TGCCACTCCC |
CTCACTCTTC |
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| 5921 |
TCTTTTCCCC |
ACAGCCTTTT |
TCACATAGCT |
CTTGGCTGTA |
GGATTGCCCC |
ACTCCAAAAA |
CCAGTGTGTG |
GAGGTCCAGG |
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| 6001 |
AGTGAGACCA |
GGAAAGAATG |
TGAAAGTGAC |
TACACAAGGA |
CTCCTCGATG |
GTCGTGGAAA |
AGGAAAGTCA |
ATTGGCAGAG |
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| 6081 |
CCCCTGAAGC |
CAGTCTTCAG |
GACAAAGAAG |
GAGCCTAGAG |
ACAGAAATGA |
CAGATCTCTG |
CTTTGGAAAT |
CACACGTCTG |
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| 6161 |
GCTTCACAGA |
TGTGTGATTC |
ACAGTGTGAA |
TCTTGGTGTC |
TACGTTACCA |
GGCAGGAAGG |
CTGAGAGGAG |
AGAGACTCCA |
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| 6241 |
GCTGGGTTGG |
AAAACAGTAT |
TTTCCAAACT |
ACCTTCCAGT |
TCCTCATTTT |
TGAATACAGG |
CATAGAGTTC |
AGACTTTTTT |
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| 6321 |
TAAATAGTAA |
AAATAAAATT |
AAAGCTGAAA |
ACTGCAACTT |
GTAAATGTGG |
TAAAGAGTTA |
GTTTGAGTTA |
CTATCATGTC |
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| 6401 |
AAACGTGAAA |
ATGCTGTATT |
AGTCACAGAG |
ATAATTCTAG |
CTTTGAGCTT |
AAGAATTTTG |
AGCAGGTGGT |
ATGTTTGGGA |
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| 6481 |
GACTGCTGAG |
TCAACCCAAT |
AGTTGTTGAT |
TGGCAGGAGT |
TGGAAGTGTG |
TGATCTGTGG |
GCACATTAGC |
CTATGTGCAT |
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| 6561 |
GCAGCATCTA |
AGTAATGATG |
TCGTTTGAAT |
CACAGTATAC |
GCTCCATCGC |
TGTCATCTCA |
GCTGGATCTC |
CATTCTCTCA |
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| 6641 |
GGCTTGCTGC |
CAAAAGCCTT |
TTGTGTTTTG |
TTTTGTATCA |
TTATGAAGTC |
ATGCGTTTAA |
TCACATTCGA |
GTGTTTCAGT |
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| 6721 |
GCTTCGCAGA |
TGTCCTTGAT |
GCTCATATTG |
TTCCCTATTT |
TGCCAGTGGG |
AACTCCTAAA |
TCAAGTTGGC |
TTCTAATCAA |
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| 6801 |
AGCTTTTAAA |
CCCTATTGGT |
AAAGAATGGA |
AGGTGGAGAA |
GCTCCCTGAA |
GTAAGCAAAG |
ACTTTCCTCT |
TAGTCGAGCC |
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| 6881 |
AAGTTAAGAA |
TGTTCTTATG |
TTGCCCAGTG |
TGTTTCTGAT |
CTGATGCAAG |
CAAGAAACAC |
TGGGCTTCTA |
GAACCAGGCA |
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| 6961 |
ACTTGGGAAC |
TAGACTCCCA |
AGCTGGACTA |
TGGCTCTACT |
TTCAGGCCAC |
ATGGCTAAAG |
AAGGTTTCAG |
AAAGAAGTGG |
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| 7041 |
GGACAGAGCA |
GAACTTTCAC |
CTTCATATAT |
TTGTATGATC |
CTAATGAATG |
CATAAAATGT |
TAAGTTGATG |
GTGATGAAAT |
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| 7121 |
GTAAATACTG |
TTTTTAACAA |
CTATGATTTG |
GAAAATAAAT |
CAATGCTATA |
ACTATGTTG |
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>ref|Gene_ID:729230|CCR2|NC_000003.11:46395234...46402412 (+)
CTTTATTCTCTGGAACATGAAACATTCTGTTGTGCTCATATCATGCAAATTATCACTAGTAGGAGAGCAGAGAGTGGAAA
TGTTCCAGGTATAAAGACCCACAAGATAAAGAAGCTCAGAGTCGTTAGAAACAGGAGCAGATGTACAGGGTTTGCCTGAC
TCACACTCAAGGTTGCATAAGCAAGATTTCAAAATTAATCCTATTCTGGAGACCTCAACCCAATGTACAATGTTCCTGAC
TGGAAAAGAAGAACTATATTTTTCTGATTTTTTTTTTCAAATCTTTACCATTAGTTGCCCTGTATCTCCGCCTTCACTTT
CTGCAGGAAACTTTATTTCCTACTTCTGCATGCCAAGTTTCTACCTCTAGATCTGTTTGGTTCAGTTGCTGAGAAGCCTG
ACATACCAGGACTGCCTGAGACAAGCCACAAGCTGGTGAGTTGTAGGCATTTTTTCCATTACTTTCTGATTCATAGGCTC
AACGCACCTCAAAGCTGGAAATGCCGGGTCTGGGTACACCCTGGGGAACTGCAAAGCCTGCACACTTGGGGGGAATGATC
AAGATGAGAGGCAGGGGTGGGGATGGCATGTGCACCAGGAGATGTTAGAGAAACCCTGAGGAAGAGCAGCGTGCAGCAGG
TGATGGGGGAGAGTGGGCAGCAAGCGAGGCCAGGACAGCCACTCTGCTCAGTCACCAGTCCACACACCCAGGGGCTCACT
CTGCCCCTCTGAGCACCCAAGGACGTTAAAGAGCTGGAACTGTTAGTCTAAATATAGGACCATCCAAGCTCTGAACCAAA
ATGTGTCCCTTGCCTCAACTCAGGAGATCCACAGAGGCAGAAGTAAGGAATTTATTTTCTGAAAGATAGATTTCTATCAG
TTCTGGGTGACATGTTCTGACACTTGAAATGACACCTAGGACAGCACATTTCAGGCATCTTGCTCATTGTTCACTGTAGT
AGAAGCTACATGCTAGCCAGTTGTAAAAATGAAATTAAGTAATGTGTGCACAGCATTTAACATAGCATCTGAGCTTCAGG
AGCACTCAATTAATGACCACAGTTGTGATTCTTTAGGCAGATGCATTTTTTTCCAACTTTGATCAGAGGTCTTATTTAGC
TTCTCCAGATTTCAAGAATCTGGCTCAGTGATATGAAATACAAGACTTGTGAAAAGTGTCAATTGCAAGAGAAATGGAAG
GATAAAGTATACAGGTGGGTGGAAAAGAAATTCACAGTCACTGCCAGAAAAAAAATTCTTGAGAATCAAGTCCTGATGAT
GTTAGGGCTTATAGTTCTTATTATAAAGAGTTTTATGTACTCATTCAGTGAACATTTATTGGTGCCTCCTTTAGCCAGGT
ACTATCATAAGAGCTGAAAATAGAAGCATAATCCAGTCCTTGATCTTGAGGAACATGCTGTGTGTAGCAGATAACATAAT
AAGTGCTTATCTAGATGCATGCAGTGTTATGTGATAAGAGTAATATGACAGAGGATACAGATTAGGCTTCACAGAGAAGG
GGGATTTGAGCAGGAGGTATTGAAGGGTGAATAGAAGCTCACCAATCATTTTGGGCAGAGGGGCAAGGACCTGCAAAACC
ACTGAAGCATGAAGGAAATGGTGAGTTTAGGGAAAATGAAGAGAAGATGGCTGTGACTGAAGCACAGGATTTGGGATTGG
AGAAGGGACTGGAGGTGAGGCTGAAAAGAGGCAAACTCAGAAAAGATGTTGTGCTGGGCAGTCTGGACATTATCTTTGAA
GCCCACCACATATAAGTCATAGGGCTACTGGAGGTTTTAAGCTAAGAGTGACTATTCAATTTCAACTTAAGAGAAGATAG
GTTGAGAGGGAACATGGCTTGAGATGAGCCATGAGCAAAGGAAAGACTACAACAAAGCCAGGAGTGAGGAGTGTGTGAAG
CAAGAAAGTGACAGTTGAAAGCAGTGCAGAGGGGATGAATCTGAGAGGCATCTATGAGGTGGAACTCAAATGACATGATA
ATAATACAGGGCATTTCTCTGTGTCAGATGCTGTCCTAAGTCCTTACTCCATTGATCTTCACAGCAACTCAGCATAGTTA
ATATTTTATGCATAAAGAAATCGGCACTTGAAGGAGTAATTGGCCCCAGATTACACTGCCTATAAGGATTCAAATCCAGG
TTTGTTTGGCTCCAAAAACTGGCTCCTAATTTTCAGAAGGAGAAGCAACCCAGGGCAATGCCCAATTTTGCTTCTTAGGC
AATGGAGGAATCCACAATCGGAAGGAGTTTTCAGCAGTGCCCCATTTGGGGTGGGTTGAATTTGAGGTCCCTGCATGATA
CCCACTTTGCTCACTTCAGTGCCTAAAACTGAGTATGGTTCATAGTAGGTGTTCAATAAGTGTTGATGCAGTGAATACAT
GCATGGGGAGATATGCATCAGGCAATGGGAAATTCAACTCTAAGGCTTAGGGGAAAGCTGGAGCTTGAAGACAGAGCTTT
AGAAAACAGTAGCATAGAAGGGAGTAGGAACCATGAGTTTAGACAATACAATTCAGGAAGAACTTTGTAGCAAGGATAAA
GAGGCAAAAAATTAAAGAGGTGAGAGCTAAGTGTGGTGCCTGGGGAATCTTAAGGTGTGGGCACGGGGAGGAGATGCCAG
CAAAGAACATGAATAAAAAGCGGTAGCACAGCCCCTCCCATCTGGAAGCCAAAAAGAATTGTAAATGGAGGAAGTTAGCA
GAAGGATCAAATACTTGAAGAGGGTGGAATTGGAATAAAACCAGGGCATTTGAAAAATTGGGTTGTCACTGCAATCTTAA
CAAGAGAAGTTTTGGCAGGATGATGGAGGCAGAAAGCTGAGAGAATCATCAGTTAGAACGTTTTTGACTTCAGAGAACAG
AAAATGCAGTTCATAATGGCTTTAAAACAGGGGCTTGTTTTTCTCCCAGCAATTTGAGAGGCCAAGGCGGGTGCATCAGG
AGGTCAAGAGACCGAGACCATCCTGGCCAACATGGTGAATCCCCATCTCTACTAAAAATACAAAAATTAGCGGGGCATGG
TGGTGCACGCCTATAGTCCCATCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGTGGAGGTTGCAGTG
AGCTGAGATCATGGCCACTGCACTATAGCCTGGAGACACAGCGAGACTCCGTCTCCAAAAAAAAAAAAAAAAGAAGGCAG
AAGGTGAATAGTTCAAGGGTGGGTTTAGGACTCAGTGATAATAGGATTCTGCCTGGCTTCTCATGGTTCTCTAGGTCTTC
CATTCATGGCACCATGCCCTCACTAGGCATGCTGCCAGAGCAGGAGGGGCAGGTGGAGGGTTCTCTTGTGTCTGTCTTAT
CAGGGAAGAAGAGCTTTCTCAGAAGCCCCCAGCAGACTCCCTTTTCATATTATGGTCCAGCAATGAGTCACAGACCTATG
CACCACCTGCAAAGGAGCCAGAGAAAACAAACGCCCAGCGCTTTTAGCCTGAAAATGAGAATCTGGTTTGCTGGGGAAGA
TAAAGGGTGTCGGAAAATGGCTGTTGGGTAAATCATTGATGTCTGCCACTAGGAATGAAAGGCAAATCAGGAACTGGCAC
ACATGCTTTCAGGGAGATGGCTGCAAGGGAGAGGGCAAAGACTGGGAAGTTGCTTATGTGGTGCCAGACTATTTGGAAGA
TCATGGATTGCGGTGTTTGTGTTGTGTGGTCATCATTTTGTTCTTTGTTTACAGAACAGAGAAAGTGGATTGAACAAGGA
CGCATTTCCCCAGTACATCCACAACATGCTGTCCACATCTCGTTCTCGGTTTATCAGAAATACCAACGAGAGCGGTGAAG
AAGTCACCACCTTTTTTGATTATGATTACGGTGCTCCCTGTCATAAATTTGACGTGAAGCAAATTGGGGCCCAACTCCTG
CCTCCGCTCTACTCGCTGGTGTTCATCTTTGGTTTTGTGGGCAACATGCTGGTCGTCCTCATCTTAATAAACTGCAAAAA
GCTGAAGTGCTTGACTGACATTTACCTGCTCAACCTGGCCATCTCTGATCTGCTTTTTCTTATTACTCTCCCATTGTGGG
CTCACTCTGCTGCAAATGAGTGGGTCTTTGGGAATGCAATGTGCAAATTATTCACAGGGCTGTATCACATCGGTTATTTT
GGCGGAATCTTCTTCATCATCCTCCTGACAATCGATAGATACCTGGCTATTGTCCATGCTGTGTTTGCTTTAAAAGCCAG
GACGGTCACCTTTGGGGTGGTGACAAGTGTGATCACCTGGTTGGTGGCTGTGTTTGCTTCTGTCCCAGGAATCATCTTTA
CTAAATGCCAGAAAGAAGATTCTGTTTATGTCTGTGGCCCTTATTTTCCACGAGGATGGAATAATTTCCACACAATAATG
AGGAACATTTTGGGGCTGGTCCTGCCGCTGCTCATCATGGTCATCTGCTACTCGGGAATCCTGAAAACCCTGCTTCGGTG
TCGAAACGAGAAGAAGAGGCATAGGGCAGTGAGAGTCATCTTCACCATCATGATTGTTTACTTTCTCTTCTGGACTCCCT
ATAATATTGTCATTCTCCTGAACACCTTCCAGGAATTCTTCGGCCTGAGTAACTGTGAAAGCACCAGTCAACTGGACCAA
GCCACGCAGGTGACAGAGACTCTTGGGATGACTCACTGCTGCATCAATCCCATCATCTATGCCTTCGTTGGGGAGAAGTT
CAGAAGGTATCTCTCGGTGTTCTTCCGAAAGCACATCACCAAGCGCTTCTGCAAACAATGTCCAGTTTTCTACAGGGAGA
CAGTGGATGGAGTGACTTCAACAAACACGCCTTCCACTGGGGAGCAGGAAGTCTCGGCTGGTTTATAAAACGAGGAGCAG
TTTGATTGTTGTTTATAAAGGGAGATAACAATCTGTATATAACAACAAACTTCAAGGGTTTGTTGAACAATAGAAACCTG
TAAAGCAGGTGCCCAGGAACCTCAGGGCTGTGTGTACTAATACAGACTATGTCACCCAATGCATATCCAACATGTGCTCA
GGGAATAATCCAGAAAAACTGTGGGTAGAGACTTTGACTCTCCAGAAAGCTCATCTCAGCTCCTGAAAAATGCCTCATTA
CCTTGTGCTAATCCTCTTTTTCTAGTCTTCATAATTTCTTCACTCAATCTCTGATTCTGTCAATGTCTTGAAATCAAGGG
CCAGCTGGAGGTGAAGAAGAGAATGTGACAGGCACAGATGAATGGGAGTGAGGGATAGTGGGGTCAGGGCTGAGAGGAGA
AGGAGGGAGACATGAGCATGGCTGAGCCTGGACAAAGACAAAGGTGAGCAAAGGGCTCACGCATTCAGCCAGGAGATGAT
ACTGGTCCTTAGCCCCATCTGCCACGTGTATTTAACCTTGAAGGGTTCACCAGGTCAGGGAGAGTTTGGGAACTGCAATA
ACCTGGGAGTTTTGGTGGAGTCCGATGATTCTCTTTTGCATAAGTGCATGACATATTTTTGCTTTATTACAGTTTATCTA
TGGCACCCATGCACCTTACATTTGAAATCTATGAAATATCATGCTCCATTGTTCAGATGCTTCTTAGGCCACATCCCCCT
GTCTAAAAATTCAGAAAATTTTTGTTTATAAAAGATGCATTATCTATGATATGCTAATATATGTATATGCAATATATATA
GGCTCTTGCTTGATCTCTCCAGGAGGTAGTGATTATGAGAAGGGGGTGGAGAATGATGAGTTCCTTCACCAGGAGCAAAG
GACGGGGATCGTGTGGAACCACTGCAGAACTATTTCCGAAATCAACTAAGTGGAGAGAGCCAGGAAGGCTGCATCAGAAC
CCAGTAAAGCTTCTTGTCTGGATCTGAGCTGGTTTGTTTTGTGCTTGCTTTTCCCTGCCTTGCCACTCCCCTCACTCTTC
TCTTTTCCCCACAGCCTTTTTCACATAGCTCTTGGCTGTAGGATTGCCCCACTCCAAAAACCAGTGTGTGGAGGTCCAGG
AGTGAGACCAGGAAAGAATGTGAAAGTGACTACACAAGGACTCCTCGATGGTCGTGGAAAAGGAAAGTCAATTGGCAGAG
CCCCTGAAGCCAGTCTTCAGGACAAAGAAGGAGCCTAGAGACAGAAATGACAGATCTCTGCTTTGGAAATCACACGTCTG
GCTTCACAGATGTGTGATTCACAGTGTGAATCTTGGTGTCTACGTTACCAGGCAGGAAGGCTGAGAGGAGAGAGACTCCA
GCTGGGTTGGAAAACAGTATTTTCCAAACTACCTTCCAGTTCCTCATTTTTGAATACAGGCATAGAGTTCAGACTTTTTT
TAAATAGTAAAAATAAAATTAAAGCTGAAAACTGCAACTTGTAAATGTGGTAAAGAGTTAGTTTGAGTTACTATCATGTC
AAACGTGAAAATGCTGTATTAGTCACAGAGATAATTCTAGCTTTGAGCTTAAGAATTTTGAGCAGGTGGTATGTTTGGGA
GACTGCTGAGTCAACCCAATAGTTGTTGATTGGCAGGAGTTGGAAGTGTGTGATCTGTGGGCACATTAGCCTATGTGCAT
GCAGCATCTAAGTAATGATGTCGTTTGAATCACAGTATACGCTCCATCGCTGTCATCTCAGCTGGATCTCCATTCTCTCA
GGCTTGCTGCCAAAAGCCTTTTGTGTTTTGTTTTGTATCATTATGAAGTCATGCGTTTAATCACATTCGAGTGTTTCAGT
GCTTCGCAGATGTCCTTGATGCTCATATTGTTCCCTATTTTGCCAGTGGGAACTCCTAAATCAAGTTGGCTTCTAATCAA
AGCTTTTAAACCCTATTGGTAAAGAATGGAAGGTGGAGAAGCTCCCTGAAGTAAGCAAAGACTTTCCTCTTAGTCGAGCC
AAGTTAAGAATGTTCTTATGTTGCCCAGTGTGTTTCTGATCTGATGCAAGCAAGAAACACTGGGCTTCTAGAACCAGGCA
ACTTGGGAACTAGACTCCCAAGCTGGACTATGGCTCTACTTTCAGGCCACATGGCTAAAGAAGGTTTCAGAAAGAAGTGG
GGACAGAGCAGAACTTTCACCTTCATATATTTGTATGATCCTAATGAATGCATAAAATGTTAAGTTGATGGTGATGAAAT
GTAAATACTGTTTTTAACAACTATGATTTGGAAAATAAATCAATGCTATAACTATGTTG
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| Primary source |
RefSeq : NM_001123041.2 (GI:183979979)
|
| Name |
Chemokine (C-C motif) receptor 2 (CCR2), transcript variant A
|
| Type of transcript |
mRNA
|
| Organism |
Homo sapiens
|
| Length |
2689 nt
|
| Map |
3p21.31
|
| Location |
Chromosome 3 (NC_000003.11) strand : +
| 46395234...46395667 | 46398967...46399958 | 46401167...46402412 |
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| Exon(s) |
Start |
End |
Length |
is coding |
|
Exon 1
|
1
|
434
|
434
|
1
|
|
Exon 2a
|
435
|
1426
|
992
|
1
|
|
Exon 3
|
1427
|
2672
|
1246
|
1
|
|
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| Primary source |
NCBI : CCDS43078
|
| Nucleotide |
CCR2, mRNA isoform A[NM_001123041.2] : 486...1610
|
| Length |
1125
|
| Location |
Chromosome 3 (NC_000003.11) strand : +
| 46399018...46399958 | 46401167...46401350 |
|
| Start codon |
1
|
| Translation |
NP_001116513.2 |
|
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| 1 |
TTTATTCTCT |
GGAACATGAA |
ACATTCTGTT |
GTGCTCATAT |
CATGCAAATT |
ATCACTAGTA |
GGAGAGCAGA |
GAGTGGAAAT |
|
| 81 |
GTTCCAGGTA |
TAAAGACCCA |
CAAGATAAAG |
AAGCTCAGAG |
TCGTTAGAAA |
CAGGAGCAGA |
TGTACAGGGT |
TTGCCTGACT |
|
| 161 |
CACACTCAAG |
GTTGCATAAG |
CAAGATTTCA |
AAATTAATCC |
TATTCTGGAG |
ACCTCAACCC |
AATGTACAAT |
GTTCCTGACT |
|
| 241 |
GGAAAAGAAG |
AACTATATTT |
TTCTGATTTT |
TTTTTTCAAA |
TCTTTACCAT |
TAGTTGCCCT |
GTATCTCCGC |
CTTCACTTTC |
|
| 321 |
TGCAGGAAAC |
TTTATTTCCT |
ACTTCTGCAT |
GCCAAGTTTC |
TACCTCTAGA |
TCTGTTTGGT |
TCAGTTGCTG |
AGAAGCCTGA |
|
| 401 |
CATACCAGGA |
CTGCCTGAGA |
CAAGCCACAA |
GCTGAACAGA |
GAAAGTGGAT |
TGAACAAGGA |
CGCATTTCCC |
CAGTACATCC |
|
| 481 |
ACAACATGCT |
GTCCACATCT |
CGTTCTCGGT |
TTATCAGAAA |
TACCAACGAG |
AGCGGTGAAG |
AAGTCACCAC |
CTTTTTTGAT |
|
| 561 |
TATGATTACG |
GTGCTCCCTG |
TCATAAATTT |
GACGTGAAGC |
AAATTGGGGC |
CCAACTCCTG |
CCTCCGCTCT |
ACTCGCTGGT |
|
| 641 |
GTTCATCTTT |
GGTTTTGTGG |
GCAACATGCT |
GGTCGTCCTC |
ATCTTAATAA |
ACTGCAAAAA |
GCTGAAGTGC |
TTGACTGACA |
|
| 721 |
TTTACCTGCT |
CAACCTGGCC |
ATCTCTGATC |
TGCTTTTTCT |
TATTACTCTC |
CCATTGTGGG |
CTCACTCTGC |
TGCAAATGAG |
|
| 801 |
TGGGTCTTTG |
GGAATGCAAT |
GTGCAAATTA |
TTCACAGGGC |
TGTATCACAT |
CGGTTATTTT |
GGCGGAATCT |
TCTTCATCAT |
|
| 881 |
CCTCCTGACA |
ATCGATAGAT |
ACCTGGCTAT |
TGTCCATGCT |
GTGTTTGCTT |
TAAAAGCCAG |
GACGGTCACC |
TTTGGGGTGG |
|
| 961 |
TGACAAGTGT |
GATCACCTGG |
TTGGTGGCTG |
TGTTTGCTTC |
TGTCCCAGGA |
ATCATCTTTA |
CTAAATGCCA |
GAAAGAAGAT |
|
| 1041 |
TCTGTTTATG |
TCTGTGGCCC |
TTATTTTCCA |
CGAGGATGGA |
ATAATTTCCA |
CACAATAATG |
AGGAACATTT |
TGGGGCTGGT |
|
| 1121 |
CCTGCCGCTG |
CTCATCATGG |
TCATCTGCTA |
CTCGGGAATC |
CTGAAAACCC |
TGCTTCGGTG |
TCGAAACGAG |
AAGAAGAGGC |
|
| 1201 |
ATAGGGCAGT |
GAGAGTCATC |
TTCACCATCA |
TGATTGTTTA |
CTTTCTCTTC |
TGGACTCCCT |
ATAATATTGT |
CATTCTCCTG |
|
| 1281 |
AACACCTTCC |
AGGAATTCTT |
CGGCCTGAGT |
AACTGTGAAA |
GCACCAGTCA |
ACTGGACCAA |
GCCACGCAGG |
TGACAGAGAC |
|
| 1361 |
TCTTGGGATG |
ACTCACTGCT |
GCATCAATCC |
CATCATCTAT |
GCCTTCGTTG |
GGGAGAAGTT |
CAGAAGCCTT |
TTTCACATAG |
|
| 1441 |
CTCTTGGCTG |
TAGGATTGCC |
CCACTCCAAA |
AACCAGTGTG |
TGGAGGTCCA |
GGAGTGAGAC |
CAGGAAAGAA |
TGTGAAAGTG |
|
| 1521 |
ACTACACAAG |
GACTCCTCGA |
TGGTCGTGGA |
AAAGGAAAGT |
CAATTGGCAG |
AGCCCCTGAA |
GCCAGTCTTC |
AGGACAAAGA |
|
| 1601 |
AGGAGCCTAG |
AGACAGAAAT |
GACAGATCTC |
TGCTTTGGAA |
ATCACACGTC |
TGGCTTCACA |
GATGTGTGAT |
TCACAGTGTG |
|
| 1681 |
AATCTTGGTG |
TCTACGTTAC |
CAGGCAGGAA |
GGCTGAGAGG |
AGAGAGACTC |
CAGCTGGGTT |
GGAAAACAGT |
ATTTTCCAAA |
|
| 1761 |
CTACCTTCCA |
GTTCCTCATT |
TTTGAATACA |
GGCATAGAGT |
TCAGACTTTT |
TTTAAATAGT |
AAAAATAAAA |
TTAAAGCTGA |
|
| 1841 |
AAACTGCAAC |
TTGTAAATGT |
GGTAAAGAGT |
TAGTTTGAGT |
TACTATCATG |
TCAAACGTGA |
AAATGCTGTA |
TTAGTCACAG |
|
| 1921 |
AGATAATTCT |
AGCTTTGAGC |
TTAAGAATTT |
TGAGCAGGTG |
GTATGTTTGG |
GAGACTGCTG |
AGTCAACCCA |
ATAGTTGTTG |
|
| 2001 |
ATTGGCAGGA |
GTTGGAAGTG |
TGTGATCTGT |
GGGCACATTA |
GCCTATGTGC |
ATGCAGCATC |
TAAGTAATGA |
TGTCGTTTGA |
|
| 2081 |
ATCACAGTAT |
ACGCTCCATC |
GCTGTCATCT |
CAGCTGGATC |
TCCATTCTCT |
CAGGCTTGCT |
GCCAAAAGCC |
TTTTGTGTTT |
|
| 2161 |
TGTTTTGTAT |
CATTATGAAG |
TCATGCGTTT |
AATCACATTC |
GAGTGTTTCA |
GTGCTTCGCA |
GATGTCCTTG |
ATGCTCATAT |
|
| 2241 |
TGTTCCCTAT |
TTTGCCAGTG |
GGAACTCCTA |
AATCAAGTTG |
GCTTCTAATC |
AAAGCTTTTA |
AACCCTATTG |
GTAAAGAATG |
|
| 2321 |
GAAGGTGGAG |
AAGCTCCCTG |
AAGTAAGCAA |
AGACTTTCCT |
CTTAGTCGAG |
CCAAGTTAAG |
AATGTTCTTA |
TGTTGCCCAG |
|
| 2401 |
TGTGTTTCTG |
ATCTGATGCA |
AGCAAGAAAC |
ACTGGGCTTC |
TAGAACCAGG |
CAACTTGGGA |
ACTAGACTCC |
CAAGCTGGAC |
|
| 2481 |
TATGGCTCTA |
CTTTCAGGCC |
ACATGGCTAA |
AGAAGGTTTC |
AGAAAGAAGT |
GGGGACAGAG |
CAGAACTTTC |
ACCTTCATAT |
|
| 2561 |
ATTTGTATGA |
TCCTAATGAA |
TGCATAAAAT |
GTTAAGTTGA |
TGGTGATGAA |
ATGTAAATAC |
TGTTTTTAAC |
AACTATGATT |
|
| 2641 |
TGGAAAATAA |
ATCAATGCTA |
TAACTATGTT |
GAAAAAAAAA |
AAAAAAAAA |
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>gi|183979979|ref|NM_001123041.2|Chemokine (C-C motif) receptor 2 (CCR2), transcript variant A
TTTATTCTCTGGAACATGAAACATTCTGTTGTGCTCATATCATGCAAATTATCACTAGTAGGAGAGCAGAGAGTGGAAAT
GTTCCAGGTATAAAGACCCACAAGATAAAGAAGCTCAGAGTCGTTAGAAACAGGAGCAGATGTACAGGGTTTGCCTGACT
CACACTCAAGGTTGCATAAGCAAGATTTCAAAATTAATCCTATTCTGGAGACCTCAACCCAATGTACAATGTTCCTGACT
GGAAAAGAAGAACTATATTTTTCTGATTTTTTTTTTCAAATCTTTACCATTAGTTGCCCTGTATCTCCGCCTTCACTTTC
TGCAGGAAACTTTATTTCCTACTTCTGCATGCCAAGTTTCTACCTCTAGATCTGTTTGGTTCAGTTGCTGAGAAGCCTGA
CATACCAGGACTGCCTGAGACAAGCCACAAGCTGAACAGAGAAAGTGGATTGAACAAGGACGCATTTCCCCAGTACATCC
ACAACATGCTGTCCACATCTCGTTCTCGGTTTATCAGAAATACCAACGAGAGCGGTGAAGAAGTCACCACCTTTTTTGAT
TATGATTACGGTGCTCCCTGTCATAAATTTGACGTGAAGCAAATTGGGGCCCAACTCCTGCCTCCGCTCTACTCGCTGGT
GTTCATCTTTGGTTTTGTGGGCAACATGCTGGTCGTCCTCATCTTAATAAACTGCAAAAAGCTGAAGTGCTTGACTGACA
TTTACCTGCTCAACCTGGCCATCTCTGATCTGCTTTTTCTTATTACTCTCCCATTGTGGGCTCACTCTGCTGCAAATGAG
TGGGTCTTTGGGAATGCAATGTGCAAATTATTCACAGGGCTGTATCACATCGGTTATTTTGGCGGAATCTTCTTCATCAT
CCTCCTGACAATCGATAGATACCTGGCTATTGTCCATGCTGTGTTTGCTTTAAAAGCCAGGACGGTCACCTTTGGGGTGG
TGACAAGTGTGATCACCTGGTTGGTGGCTGTGTTTGCTTCTGTCCCAGGAATCATCTTTACTAAATGCCAGAAAGAAGAT
TCTGTTTATGTCTGTGGCCCTTATTTTCCACGAGGATGGAATAATTTCCACACAATAATGAGGAACATTTTGGGGCTGGT
CCTGCCGCTGCTCATCATGGTCATCTGCTACTCGGGAATCCTGAAAACCCTGCTTCGGTGTCGAAACGAGAAGAAGAGGC
ATAGGGCAGTGAGAGTCATCTTCACCATCATGATTGTTTACTTTCTCTTCTGGACTCCCTATAATATTGTCATTCTCCTG
AACACCTTCCAGGAATTCTTCGGCCTGAGTAACTGTGAAAGCACCAGTCAACTGGACCAAGCCACGCAGGTGACAGAGAC
TCTTGGGATGACTCACTGCTGCATCAATCCCATCATCTATGCCTTCGTTGGGGAGAAGTTCAGAAGCCTTTTTCACATAG
CTCTTGGCTGTAGGATTGCCCCACTCCAAAAACCAGTGTGTGGAGGTCCAGGAGTGAGACCAGGAAAGAATGTGAAAGTG
ACTACACAAGGACTCCTCGATGGTCGTGGAAAAGGAAAGTCAATTGGCAGAGCCCCTGAAGCCAGTCTTCAGGACAAAGA
AGGAGCCTAGAGACAGAAATGACAGATCTCTGCTTTGGAAATCACACGTCTGGCTTCACAGATGTGTGATTCACAGTGTG
AATCTTGGTGTCTACGTTACCAGGCAGGAAGGCTGAGAGGAGAGAGACTCCAGCTGGGTTGGAAAACAGTATTTTCCAAA
CTACCTTCCAGTTCCTCATTTTTGAATACAGGCATAGAGTTCAGACTTTTTTTAAATAGTAAAAATAAAATTAAAGCTGA
AAACTGCAACTTGTAAATGTGGTAAAGAGTTAGTTTGAGTTACTATCATGTCAAACGTGAAAATGCTGTATTAGTCACAG
AGATAATTCTAGCTTTGAGCTTAAGAATTTTGAGCAGGTGGTATGTTTGGGAGACTGCTGAGTCAACCCAATAGTTGTTG
ATTGGCAGGAGTTGGAAGTGTGTGATCTGTGGGCACATTAGCCTATGTGCATGCAGCATCTAAGTAATGATGTCGTTTGA
ATCACAGTATACGCTCCATCGCTGTCATCTCAGCTGGATCTCCATTCTCTCAGGCTTGCTGCCAAAAGCCTTTTGTGTTT
TGTTTTGTATCATTATGAAGTCATGCGTTTAATCACATTCGAGTGTTTCAGTGCTTCGCAGATGTCCTTGATGCTCATAT
TGTTCCCTATTTTGCCAGTGGGAACTCCTAAATCAAGTTGGCTTCTAATCAAAGCTTTTAAACCCTATTGGTAAAGAATG
GAAGGTGGAGAAGCTCCCTGAAGTAAGCAAAGACTTTCCTCTTAGTCGAGCCAAGTTAAGAATGTTCTTATGTTGCCCAG
TGTGTTTCTGATCTGATGCAAGCAAGAAACACTGGGCTTCTAGAACCAGGCAACTTGGGAACTAGACTCCCAAGCTGGAC
TATGGCTCTACTTTCAGGCCACATGGCTAAAGAAGGTTTCAGAAAGAAGTGGGGACAGAGCAGAACTTTCACCTTCATAT
ATTTGTATGATCCTAATGAATGCATAAAATGTTAAGTTGATGGTGATGAAATGTAAATACTGTTTTTAACAACTATGATT
TGGAAAATAAATCAATGCTATAACTATGTTGAAAAAAAAAAAAAAAAAA
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|
| Primary source |
RefSeq : NM_001123396.1 (GI:183979981)
|
| Name |
Chemokine (C-C motif) receptor 2 (CCR2), transcript variant B
|
| Type of transcript |
mRNA
|
| Organism |
Homo sapiens
|
| Length |
2335 nt
|
| Map |
3p21.31
|
| Location |
Chromosome 3 (NC_000003.11) strand : +
| 46395234...46395667 | 46398967...46400867 |
|
|
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|
|
|
|
|
|
|
|
|
|
| Exon(s) |
Start |
End |
Length |
is coding |
|
Exon 1
|
1
|
434
|
434
|
1
|
|
Exon 2b
|
435
|
2335
|
1901
|
1
|
|
|
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|
|
|
|
|
|
|
|
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|
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|
|
| Primary source |
NCBI : CCDS46813
|
| Nucleotide |
CCR2, mRNA isoform B[NM_001123396.1] : 486...1568
|
| Length |
1083
|
| Location |
Chromosome 3 (NC_000003.11) strand : +
|
| Start codon |
1
|
| Translation |
NP_001116868.1 |
|
|
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|
|
|
|
|
|
|
|
|
| 1 |
TTTATTCTCT |
GGAACATGAA |
ACATTCTGTT |
GTGCTCATAT |
CATGCAAATT |
ATCACTAGTA |
GGAGAGCAGA |
GAGTGGAAAT |
|
| 81 |
GTTCCAGGTA |
TAAAGACCCA |
CAAGATAAAG |
AAGCTCAGAG |
TCGTTAGAAA |
CAGGAGCAGA |
TGTACAGGGT |
TTGCCTGACT |
|
| 161 |
CACACTCAAG |
GTTGCATAAG |
CAAGATTTCA |
AAATTAATCC |
TATTCTGGAG |
ACCTCAACCC |
AATGTACAAT |
GTTCCTGACT |
|
| 241 |
GGAAAAGAAG |
AACTATATTT |
TTCTGATTTT |
TTTTTTCAAA |
TCTTTACCAT |
TAGTTGCCCT |
GTATCTCCGC |
CTTCACTTTC |
|
| 321 |
TGCAGGAAAC |
TTTATTTCCT |
ACTTCTGCAT |
GCCAAGTTTC |
TACCTCTAGA |
TCTGTTTGGT |
TCAGTTGCTG |
AGAAGCCTGA |
|
| 401 |
CATACCAGGA |
CTGCCTGAGA |
CAAGCCACAA |
GCTGAACAGA |
GAAAGTGGAT |
TGAACAAGGA |
CGCATTTCCC |
CAGTACATCC |
|
| 481 |
ACAACATGCT |
GTCCACATCT |
CGTTCTCGGT |
TTATCAGAAA |
TACCAACGAG |
AGCGGTGAAG |
AAGTCACCAC |
CTTTTTTGAT |
|
| 561 |
TATGATTACG |
GTGCTCCCTG |
TCATAAATTT |
GACGTGAAGC |
AAATTGGGGC |
CCAACTCCTG |
CCTCCGCTCT |
ACTCGCTGGT |
|
| 641 |
GTTCATCTTT |
GGTTTTGTGG |
GCAACATGCT |
GGTCGTCCTC |
ATCTTAATAA |
ACTGCAAAAA |
GCTGAAGTGC |
TTGACTGACA |
|
| 721 |
TTTACCTGCT |
CAACCTGGCC |
ATCTCTGATC |
TGCTTTTTCT |
TATTACTCTC |
CCATTGTGGG |
CTCACTCTGC |
TGCAAATGAG |
|
| 801 |
TGGGTCTTTG |
GGAATGCAAT |
GTGCAAATTA |
TTCACAGGGC |
TGTATCACAT |
CGGTTATTTT |
GGCGGAATCT |
TCTTCATCAT |
|
| 881 |
CCTCCTGACA |
ATCGATAGAT |
ACCTGGCTAT |
TGTCCATGCT |
GTGTTTGCTT |
TAAAAGCCAG |
GACGGTCACC |
TTTGGGGTGG |
|
| 961 |
TGACAAGTGT |
GATCACCTGG |
TTGGTGGCTG |
TGTTTGCTTC |
TGTCCCAGGA |
ATCATCTTTA |
CTAAATGCCA |
GAAAGAAGAT |
|
| 1041 |
TCTGTTTATG |
TCTGTGGCCC |
TTATTTTCCA |
CGAGGATGGA |
ATAATTTCCA |
CACAATAATG |
AGGAACATTT |
TGGGGCTGGT |
|
| 1121 |
CCTGCCGCTG |
CTCATCATGG |
TCATCTGCTA |
CTCGGGAATC |
CTGAAAACCC |
TGCTTCGGTG |
TCGAAACGAG |
AAGAAGAGGC |
|
| 1201 |
ATAGGGCAGT |
GAGAGTCATC |
TTCACCATCA |
TGATTGTTTA |
CTTTCTCTTC |
TGGACTCCCT |
ATAATATTGT |
CATTCTCCTG |
|
| 1281 |
AACACCTTCC |
AGGAATTCTT |
CGGCCTGAGT |
AACTGTGAAA |
GCACCAGTCA |
ACTGGACCAA |
GCCACGCAGG |
TGACAGAGAC |
|
| 1361 |
TCTTGGGATG |
ACTCACTGCT |
GCATCAATCC |
CATCATCTAT |
GCCTTCGTTG |
GGGAGAAGTT |
CAGAAGGTAT |
CTCTCGGTGT |
|
| 1441 |
TCTTCCGAAA |
GCACATCACC |
AAGCGCTTCT |
GCAAACAATG |
TCCAGTTTTC |
TACAGGGAGA |
CAGTGGATGG |
AGTGACTTCA |
|
| 1521 |
ACAAACACGC |
CTTCCACTGG |
GGAGCAGGAA |
GTCTCGGCTG |
GTTTATAAAA |
CGAGGAGCAG |
TTTGATTGTT |
GTTTATAAAG |
|
| 1601 |
GGAGATAACA |
ATCTGTATAT |
AACAACAAAC |
TTCAAGGGTT |
TGTTGAACAA |
TAGAAACCTG |
TAAAGCAGGT |
GCCCAGGAAC |
|
| 1681 |
CTCAGGGCTG |
TGTGTACTAA |
TACAGACTAT |
GTCACCCAAT |
GCATATCCAA |
CATGTGCTCA |
GGGAATAATC |
CAGAAAAACT |
|
| 1761 |
GTGGGTAGAG |
ACTTTGACTC |
TCCAGAAAGC |
TCATCTCAGC |
TCCTGAAAAA |
TGCCTCATTA |
CCTTGTGCTA |
ATCCTCTTTT |
|
| 1841 |
TCTAGTCTTC |
ATAATTTCTT |
CACTCAATCT |
CTGATTCTGT |
CAATGTCTTG |
AAATCAAGGG |
CCAGCTGGAG |
GTGAAGAAGA |
|
| 1921 |
GAATGTGACA |
GGCACAGATG |
AATGGGAGTG |
AGGGATAGTG |
GGGTCAGGGC |
TGAGAGGAGA |
AGGAGGGAGA |
CATGAGCATG |
|
| 2001 |
GCTGAGCCTG |
GACAAAGACA |
AAGGTGAGCA |
AAGGGCTCAC |
GCATTCAGCC |
AGGAGATGAT |
ACTGGTCCTT |
AGCCCCATCT |
|
| 2081 |
GCCACGTGTA |
TTTAACCTTG |
AAGGGTTCAC |
CAGGTCAGGG |
AGAGTTTGGG |
AACTGCAATA |
ACCTGGGAGT |
TTTGGTGGAG |
|
| 2161 |
TCCGATGATT |
CTCTTTTGCA |
TAAGTGCATG |
ACATATTTTT |
GCTTTATTAC |
AGTTTATCTA |
TGGCACCCAT |
GCACCTTACA |
|
| 2241 |
TTTGAAATCT |
ATGAAATATC |
ATGCTCCATT |
GTTCAGATGC |
TTCTTAGGCC |
ACATCCCCCT |
GTCTAAAAAT |
TCAGAAAATT |
|
| 2321 |
TTTGTTTATA |
AAAGA |
|
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|
|
>gi|183979981|ref|NM_001123396.1|Chemokine (C-C motif) receptor 2 (CCR2), transcript variant B
TTTATTCTCTGGAACATGAAACATTCTGTTGTGCTCATATCATGCAAATTATCACTAGTAGGAGAGCAGAGAGTGGAAAT
GTTCCAGGTATAAAGACCCACAAGATAAAGAAGCTCAGAGTCGTTAGAAACAGGAGCAGATGTACAGGGTTTGCCTGACT
CACACTCAAGGTTGCATAAGCAAGATTTCAAAATTAATCCTATTCTGGAGACCTCAACCCAATGTACAATGTTCCTGACT
GGAAAAGAAGAACTATATTTTTCTGATTTTTTTTTTCAAATCTTTACCATTAGTTGCCCTGTATCTCCGCCTTCACTTTC
TGCAGGAAACTTTATTTCCTACTTCTGCATGCCAAGTTTCTACCTCTAGATCTGTTTGGTTCAGTTGCTGAGAAGCCTGA
CATACCAGGACTGCCTGAGACAAGCCACAAGCTGAACAGAGAAAGTGGATTGAACAAGGACGCATTTCCCCAGTACATCC
ACAACATGCTGTCCACATCTCGTTCTCGGTTTATCAGAAATACCAACGAGAGCGGTGAAGAAGTCACCACCTTTTTTGAT
TATGATTACGGTGCTCCCTGTCATAAATTTGACGTGAAGCAAATTGGGGCCCAACTCCTGCCTCCGCTCTACTCGCTGGT
GTTCATCTTTGGTTTTGTGGGCAACATGCTGGTCGTCCTCATCTTAATAAACTGCAAAAAGCTGAAGTGCTTGACTGACA
TTTACCTGCTCAACCTGGCCATCTCTGATCTGCTTTTTCTTATTACTCTCCCATTGTGGGCTCACTCTGCTGCAAATGAG
TGGGTCTTTGGGAATGCAATGTGCAAATTATTCACAGGGCTGTATCACATCGGTTATTTTGGCGGAATCTTCTTCATCAT
CCTCCTGACAATCGATAGATACCTGGCTATTGTCCATGCTGTGTTTGCTTTAAAAGCCAGGACGGTCACCTTTGGGGTGG
TGACAAGTGTGATCACCTGGTTGGTGGCTGTGTTTGCTTCTGTCCCAGGAATCATCTTTACTAAATGCCAGAAAGAAGAT
TCTGTTTATGTCTGTGGCCCTTATTTTCCACGAGGATGGAATAATTTCCACACAATAATGAGGAACATTTTGGGGCTGGT
CCTGCCGCTGCTCATCATGGTCATCTGCTACTCGGGAATCCTGAAAACCCTGCTTCGGTGTCGAAACGAGAAGAAGAGGC
ATAGGGCAGTGAGAGTCATCTTCACCATCATGATTGTTTACTTTCTCTTCTGGACTCCCTATAATATTGTCATTCTCCTG
AACACCTTCCAGGAATTCTTCGGCCTGAGTAACTGTGAAAGCACCAGTCAACTGGACCAAGCCACGCAGGTGACAGAGAC
TCTTGGGATGACTCACTGCTGCATCAATCCCATCATCTATGCCTTCGTTGGGGAGAAGTTCAGAAGGTATCTCTCGGTGT
TCTTCCGAAAGCACATCACCAAGCGCTTCTGCAAACAATGTCCAGTTTTCTACAGGGAGACAGTGGATGGAGTGACTTCA
ACAAACACGCCTTCCACTGGGGAGCAGGAAGTCTCGGCTGGTTTATAAAACGAGGAGCAGTTTGATTGTTGTTTATAAAG
GGAGATAACAATCTGTATATAACAACAAACTTCAAGGGTTTGTTGAACAATAGAAACCTGTAAAGCAGGTGCCCAGGAAC
CTCAGGGCTGTGTGTACTAATACAGACTATGTCACCCAATGCATATCCAACATGTGCTCAGGGAATAATCCAGAAAAACT
GTGGGTAGAGACTTTGACTCTCCAGAAAGCTCATCTCAGCTCCTGAAAAATGCCTCATTACCTTGTGCTAATCCTCTTTT
TCTAGTCTTCATAATTTCTTCACTCAATCTCTGATTCTGTCAATGTCTTGAAATCAAGGGCCAGCTGGAGGTGAAGAAGA
GAATGTGACAGGCACAGATGAATGGGAGTGAGGGATAGTGGGGTCAGGGCTGAGAGGAGAAGGAGGGAGACATGAGCATG
GCTGAGCCTGGACAAAGACAAAGGTGAGCAAAGGGCTCACGCATTCAGCCAGGAGATGATACTGGTCCTTAGCCCCATCT
GCCACGTGTATTTAACCTTGAAGGGTTCACCAGGTCAGGGAGAGTTTGGGAACTGCAATAACCTGGGAGTTTTGGTGGAG
TCCGATGATTCTCTTTTGCATAAGTGCATGACATATTTTTGCTTTATTACAGTTTATCTATGGCACCCATGCACCTTACA
TTTGAAATCTATGAAATATCATGCTCCATTGTTCAGATGCTTCTTAGGCCACATCCCCCTGTCTAAAAATTCAGAAAATT
TTTGTTTATAAAAGA
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| |
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|
| Exon number |
1
|
| Length |
434 nt
|
| Location |
Chromosome 3 (NC_000003.11) : 46395234...46395667 (+)
|
| Is part of |
CCR2, mRNA isoform B
(NM_001123396.1)
CCR2, mRNA isoform A
(NM_001123041.2)
|
| Sequence |
Show
|
|
TTTATTCTCTGGAACATGAAACATTCTGTTGTGCTCATATCATGCAAATTATCACTAGTAGGAGAGCAGAGAGTGGAAAT
GTTCCAGGTATAAAGACCCACAAGATAAAGAAGCTCAGAGTCGTTAGAAACAGGAGCAGATGTACAGGGTTTGCCTGACT
CACACTCAAGGTTGCATAAGCAAGATTTCAAAATTAATCCTATTCTGGAGACCTCAACCCAATGTACAATGTTCCTGACT
GGAAAAGAAGAACTATATTTTTCTGATTTTTTTTTTCAAATCTTTACCATTAGTTGCCCTGTATCTCCGCCTTCACTTTC
TGCAGGAAACTTTATTTCCTACTTCTGCATGCCAAGTTTCTACCTCTAGATCTGTTTGGTTCAGTTGCTGAGAAGCCTGA
CATACCAGGACTGCCTGAGACAAGCCACAAGCTG
|
|
|
|
|
|
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|
|
|
|
|
| Exon number |
2b
|
| Length |
1901 nt
|
| Location |
Chromosome 3 (NC_000003.11) : 46398967...46400867 (+)
|
| Is part of |
CCR2, mRNA isoform B
(NM_001123396.1)
|
| Sequence |
Show
|
|
AACAGAGAAAGTGGATTGAACAAGGACGCATTTCCCCAGTACATCCACAACATGCTGTCCACATCTCGTTCTCGGTTTAT
CAGAAATACCAACGAGAGCGGTGAAGAAGTCACCACCTTTTTTGATTATGATTACGGTGCTCCCTGTCATAAATTTGACG
TGAAGCAAATTGGGGCCCAACTCCTGCCTCCGCTCTACTCGCTGGTGTTCATCTTTGGTTTTGTGGGCAACATGCTGGTC
GTCCTCATCTTAATAAACTGCAAAAAGCTGAAGTGCTTGACTGACATTTACCTGCTCAACCTGGCCATCTCTGATCTGCT
TTTTCTTATTACTCTCCCATTGTGGGCTCACTCTGCTGCAAATGAGTGGGTCTTTGGGAATGCAATGTGCAAATTATTCA
CAGGGCTGTATCACATCGGTTATTTTGGCGGAATCTTCTTCATCATCCTCCTGACAATCGATAGATACCTGGCTATTGTC
CATGCTGTGTTTGCTTTAAAAGCCAGGACGGTCACCTTTGGGGTGGTGACAAGTGTGATCACCTGGTTGGTGGCTGTGTT
TGCTTCTGTCCCAGGAATCATCTTTACTAAATGCCAGAAAGAAGATTCTGTTTATGTCTGTGGCCCTTATTTTCCACGAG
GATGGAATAATTTCCACACAATAATGAGGAACATTTTGGGGCTGGTCCTGCCGCTGCTCATCATGGTCATCTGCTACTCG
GGAATCCTGAAAACCCTGCTTCGGTGTCGAAACGAGAAGAAGAGGCATAGGGCAGTGAGAGTCATCTTCACCATCATGAT
TGTTTACTTTCTCTTCTGGACTCCCTATAATATTGTCATTCTCCTGAACACCTTCCAGGAATTCTTCGGCCTGAGTAACT
GTGAAAGCACCAGTCAACTGGACCAAGCCACGCAGGTGACAGAGACTCTTGGGATGACTCACTGCTGCATCAATCCCATC
ATCTATGCCTTCGTTGGGGAGAAGTTCAGAAGGTATCTCTCGGTGTTCTTCCGAAAGCACATCACCAAGCGCTTCTGCAA
ACAATGTCCAGTTTTCTACAGGGAGACAGTGGATGGAGTGACTTCAACAAACACGCCTTCCACTGGGGAGCAGGAAGTCT
CGGCTGGTTTATAAAACGAGGAGCAGTTTGATTGTTGTTTATAAAGGGAGATAACAATCTGTATATAACAACAAACTTCA
AGGGTTTGTTGAACAATAGAAACCTGTAAAGCAGGTGCCCAGGAACCTCAGGGCTGTGTGTACTAATACAGACTATGTCA
CCCAATGCATATCCAACATGTGCTCAGGGAATAATCCAGAAAAACTGTGGGTAGAGACTTTGACTCTCCAGAAAGCTCAT
CTCAGCTCCTGAAAAATGCCTCATTACCTTGTGCTAATCCTCTTTTTCTAGTCTTCATAATTTCTTCACTCAATCTCTGA
TTCTGTCAATGTCTTGAAATCAAGGGCCAGCTGGAGGTGAAGAAGAGAATGTGACAGGCACAGATGAATGGGAGTGAGGG
ATAGTGGGGTCAGGGCTGAGAGGAGAAGGAGGGAGACATGAGCATGGCTGAGCCTGGACAAAGACAAAGGTGAGCAAAGG
GCTCACGCATTCAGCCAGGAGATGATACTGGTCCTTAGCCCCATCTGCCACGTGTATTTAACCTTGAAGGGTTCACCAGG
TCAGGGAGAGTTTGGGAACTGCAATAACCTGGGAGTTTTGGTGGAGTCCGATGATTCTCTTTTGCATAAGTGCATGACAT
ATTTTTGCTTTATTACAGTTTATCTATGGCACCCATGCACCTTACATTTGAAATCTATGAAATATCATGCTCCATTGTTC
AGATGCTTCTTAGGCCACATCCCCCTGTCTAAAAATTCAGAAAATTTTTGTTTATAAAAGA
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|
|
| Exon number |
2a
|
| Length |
992 nt
|
| Location |
Chromosome 3 (NC_000003.11) : 46398967...46399958 (+)
|
| Is part of |
CCR2, mRNA isoform A
(NM_001123041.2)
|
| Sequence |
Show
|
|
AACAGAGAAAGTGGATTGAACAAGGACGCATTTCCCCAGTACATCCACAACATGCTGTCCACATCTCGTTCTCGGTTTAT
CAGAAATACCAACGAGAGCGGTGAAGAAGTCACCACCTTTTTTGATTATGATTACGGTGCTCCCTGTCATAAATTTGACG
TGAAGCAAATTGGGGCCCAACTCCTGCCTCCGCTCTACTCGCTGGTGTTCATCTTTGGTTTTGTGGGCAACATGCTGGTC
GTCCTCATCTTAATAAACTGCAAAAAGCTGAAGTGCTTGACTGACATTTACCTGCTCAACCTGGCCATCTCTGATCTGCT
TTTTCTTATTACTCTCCCATTGTGGGCTCACTCTGCTGCAAATGAGTGGGTCTTTGGGAATGCAATGTGCAAATTATTCA
CAGGGCTGTATCACATCGGTTATTTTGGCGGAATCTTCTTCATCATCCTCCTGACAATCGATAGATACCTGGCTATTGTC
CATGCTGTGTTTGCTTTAAAAGCCAGGACGGTCACCTTTGGGGTGGTGACAAGTGTGATCACCTGGTTGGTGGCTGTGTT
TGCTTCTGTCCCAGGAATCATCTTTACTAAATGCCAGAAAGAAGATTCTGTTTATGTCTGTGGCCCTTATTTTCCACGAG
GATGGAATAATTTCCACACAATAATGAGGAACATTTTGGGGCTGGTCCTGCCGCTGCTCATCATGGTCATCTGCTACTCG
GGAATCCTGAAAACCCTGCTTCGGTGTCGAAACGAGAAGAAGAGGCATAGGGCAGTGAGAGTCATCTTCACCATCATGAT
TGTTTACTTTCTCTTCTGGACTCCCTATAATATTGTCATTCTCCTGAACACCTTCCAGGAATTCTTCGGCCTGAGTAACT
GTGAAAGCACCAGTCAACTGGACCAAGCCACGCAGGTGACAGAGACTCTTGGGATGACTCACTGCTGCATCAATCCCATC
ATCTATGCCTTCGTTGGGGAGAAGTTCAGAAG
|
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|
|
|
|
| Exon number |
3
|
| Length |
1246 nt
|
| Location |
Chromosome 3 (NC_000003.11) : 46401167...46402412 (+)
|
| Is part of |
CCR2, mRNA isoform A
(NM_001123041.2)
|
| Sequence |
Show
|
|
CCTTTTTCACATAGCTCTTGGCTGTAGGATTGCCCCACTCCAAAAACCAGTGTGTGGAGGTCCAGGAGTGAGACCAGGAA
AGAATGTGAAAGTGACTACACAAGGACTCCTCGATGGTCGTGGAAAAGGAAAGTCAATTGGCAGAGCCCCTGAAGCCAGT
CTTCAGGACAAAGAAGGAGCCTAGAGACAGAAATGACAGATCTCTGCTTTGGAAATCACACGTCTGGCTTCACAGATGTG
TGATTCACAGTGTGAATCTTGGTGTCTACGTTACCAGGCAGGAAGGCTGAGAGGAGAGAGACTCCAGCTGGGTTGGAAAA
CAGTATTTTCCAAACTACCTTCCAGTTCCTCATTTTTGAATACAGGCATAGAGTTCAGACTTTTTTTAAATAGTAAAAAT
AAAATTAAAGCTGAAAACTGCAACTTGTAAATGTGGTAAAGAGTTAGTTTGAGTTACTATCATGTCAAACGTGAAAATGC
TGTATTAGTCACAGAGATAATTCTAGCTTTGAGCTTAAGAATTTTGAGCAGGTGGTATGTTTGGGAGACTGCTGAGTCAA
CCCAATAGTTGTTGATTGGCAGGAGTTGGAAGTGTGTGATCTGTGGGCACATTAGCCTATGTGCATGCAGCATCTAAGTA
ATGATGTCGTTTGAATCACAGTATACGCTCCATCGCTGTCATCTCAGCTGGATCTCCATTCTCTCAGGCTTGCTGCCAAA
AGCCTTTTGTGTTTTGTTTTGTATCATTATGAAGTCATGCGTTTAATCACATTCGAGTGTTTCAGTGCTTCGCAGATGTC
CTTGATGCTCATATTGTTCCCTATTTTGCCAGTGGGAACTCCTAAATCAAGTTGGCTTCTAATCAAAGCTTTTAAACCCT
ATTGGTAAAGAATGGAAGGTGGAGAAGCTCCCTGAAGTAAGCAAAGACTTTCCTCTTAGTCGAGCCAAGTTAAGAATGTT
CTTATGTTGCCCAGTGTGTTTCTGATCTGATGCAAGCAAGAAACACTGGGCTTCTAGAACCAGGCAACTTGGGAACTAGA
CTCCCAAGCTGGACTATGGCTCTACTTTCAGGCCACATGGCTAAAGAAGGTTTCAGAAAGAAGTGGGGACAGAGCAGAAC
TTTCACCTTCATATATTTGTATGATCCTAATGAATGCATAAAATGTTAAGTTGATGGTGATGAAATGTAAATACTGTTTT
TAACAACTATGATTTGGAAAATAAATCAATGCTATAACTATGTTGA
|
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|
| Primary source |
Uniprot : P41597
|
| Name |
C-C chemokine receptor type 2
|
| Alternative name(s) |
Monocyte chemoattractant protein 1 receptor
|
| Synonym(s) |
C-C CKR-2
CC-CKR-2
CCR-2
CCR2
MCP-1-R
|
| Organism |
Homo sapiens
|
| Length |
374 aa
|
| Protein existence |
---
|
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General annotation (Comments)
|
top
|
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|
|
Function
|
Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
|
|
Polymorphism
|
Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].
|
|
Ptm
|
N-glycosylated.
|
|
Similarity
|
Belongs to the G-protein coupled receptor 1 family.
|
|
Subcellular location
|
Cell membrane; Multi-pass membrane protein.
|
|
Subunit
|
Binds to HIV-1 Tat. Interacts with ARRB1.
|
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Biological process
|
chemotaxis [GO:0006935]
inflammatory response [GO:0006954]
immune response [GO:0006955]
cellular defense response [GO:0006968]
G-protein coupled receptor protein signaling pathway [GO:0007186]
negative regulation of adenylate cyclase activity [GO:0007194]
elevation of cytosolic calcium ion concentration [GO:0007204]
JAK-STAT cascade [GO:0007259]
cytokine-mediated signaling pathway [GO:0019221]
interspecies interaction between organisms [GO:0044419]
|
|
Cellular component
|
soluble fraction [GO:0005625]
cytoplasm [GO:0005737]
integral to plasma membrane [GO:0005887]
|
|
Molecular function
|
C-C chemokine receptor activity [GO:0016493]
CCR2 chemokine receptor binding [GO:0031727]
|
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With
|
Uniprot accession
|
IntAct
|
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Alternative product(s)
|
top
|
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|
Uniprot Identifier
|
Difference(s) with the 'canonical' sequence
|
Notes
|
Sequences
|
|
Isoform A
|
P41597-1
|
---
|
'Canonical' sequence
|
Get Fasta
|
|
Isoform B
|
P41597-2
|
314-374 : SLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGR GKGKSIGRAPEASLQDKEGA -> RYLSVFFRKHITKRFCK QCPVFYRETVDGVTSTNTPSTGEQEVSAGL
|
---
|
Get Fasta
|
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Feature key |
Position
|
Length
|
Description
|
Feature identifier
|
Region
|
|
|
|
|
|
Topological domain
|
1 - 42
|
42
|
Extracellular (Potential)
|
P41597-TOPO_DOM-1
|
|
Topological domain
|
71 - 80
|
10
|
Cytoplasmic (Potential)
|
P41597-TOPO_DOM-71
|
|
Topological domain
|
101 - 114
|
14
|
Extracellular (Potential)
|
P41597-TOPO_DOM-101
|
|
Topological domain
|
137 - 153
|
17
|
Cytoplasmic (Potential)
|
P41597-TOPO_DOM-137
|
|
Topological domain
|
179 - 206
|
28
|
Extracellular (Potential)
|
P41597-TOPO_DOM-179
|
|
Topological domain
|
227 - 243
|
17
|
Cytoplasmic (Potential)
|
P41597-TOPO_DOM-227
|
|
Topological domain
|
269 - 285
|
17
|
Extracellular (Potential)
|
P41597-TOPO_DOM-269
|
|
Topological domain
|
310 - 374
|
65
|
Cytoplasmic (Potential)
|
P41597-TOPO_DOM-310
|
|
Transmembrane
|
43 - 70
|
28
|
Helical; Name=1; (Potential)
|
P41597-TRANSMEM-43
|
|
Transmembrane
|
81 - 100
|
20
|
Helical; Name=2; (Potential)
|
P41597-TRANSMEM-81
|
|
Transmembrane
|
115 - 136
|
22
|
Helical; Name=3; (Potential)
|
P41597-TRANSMEM-115
|
|
Transmembrane
|
154 - 178
|
25
|
Helical; Name=4; (Potential)
|
P41597-TRANSMEM-154
|
|
Transmembrane
|
207 - 226
|
20
|
Helical; Name=5; (Potential)
|
P41597-TRANSMEM-207
|
|
Transmembrane
|
244 - 268
|
25
|
Helical; Name=6; (Potential)
|
P41597-TRANSMEM-244
|
|
Transmembrane
|
286 - 309
|
24
|
Helical; Name=7; (Potential)
|
P41597-TRANSMEM-286
|
Natural variations
|
|
|
|
|
|
Natural variant site
|
45 - 45
|
1
|
L -> V (in dbSNP:rs4987052)
|
VAR_020066
|
|
Natural variant site
|
64 - 64
|
1
|
V -> I (confers relative resistance to infection by HIV-1; delay in disease progression in African Americans but not in Caucasians; dbSNP:rs1799864)
|
VAR_014339
|
|
Natural variant site
|
355 - 355
|
1
|
G -> E (in dbSNP:rs3918387)
|
VAR_014340
|
|
Alternative sequence
|
314 - 374
|
61
|
SLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGR GKGKSIGRAPEASLQDKEGA -> RYLSVFFRKHITKRFCK QCPVFYRETVDGVTSTNTPSTGEQEVSAGL
|
VSP_001893
|
Amino acid modifications
|
|
|
|
|
|
Disulfide bond
|
32 - 277
|
246
|
|
P41597-DISULFID-32
|
|
Disulfide bond
|
113 - 190
|
78
|
|
P41597-DISULFID-113
|
|
Glycosylation
|
14 - 14
|
1
|
N-linked (GlcNAc...) (Potential)
|
P41597-CARBOHYD-14
|
|
Modified residue
|
26 - 26
|
1
|
Sulfotyrosine
|
P41597-MOD_RES-26
|
|
|
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|
|
| 1 |
MLSTSRSRFI |
RNTNESGEEV |
TTFFDYDYGA |
PCHKFDVKQI |
GAQLLPPLYS |
LVFIFGFVGN |
MLVVLILINC |
KKLKCLTDIY |
|
| 81 |
LLNLAISDLL |
FLITLPLWAH |
SAANEWVFGN |
AMCKLFTGLY |
HIGYFGGIFF |
IILLTIDRYL |
AIVHAVFALK |
ARTVTFGVVT |
|
| 161 |
SVITWLVAVF |
ASVPGIIFTK |
CQKEDSVYVC |
GPYFPRGWNN |
FHTIMRNILG |
LVLPLLIMVI |
CYSGILKTLL |
RCRNEKKRHR |
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| 241 |
AVRVIFTIMI |
VYFLFWTPYN |
IVILLNTFQE |
FFGLSNCEST |
SQLDQATQVT |
ETLGMTHCCI |
NPIIYAFVGE |
KFRSLFHIAL |
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| 321 |
GCRIAPLQKP |
VCGGPGVRPG |
KNVKVTTQGL |
LDGRGKGKSI |
GRAPEASLQD |
KEGA |
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>sp|P41597|CCR2_human C-C chemokine receptor type 2
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIY
LLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVT
SVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIAL
GCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
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| Primary source |
Uniprot : Q4VBL2
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| Name |
Chemokine (C-C motif) receptor 2 [submitted name]
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| Alternative name(s) |
Chemokine (C-C motif) receptor 2, isoform CRA_a [submitted name]
cDNA FLJ75394, highly similar to Homo sapiens chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, mRNA [submitted name]
cDNA FLJ78302, highly similar to Homo sapiens chemokine (C-C motif) receptor 2 (CCR2), transcript variant B, mRNA [submitted name]
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| Synonym(s) |
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| Organism |
Homo sapiens
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| Length |
360 aa
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| Protein existence |
---
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General annotation (Comments)
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top
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Similarity
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Belongs to the G-protein coupled receptor 1 family.
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Biological process
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signal transduction [GO:0007165]
G-protein coupled receptor protein signaling pathway [GO:0007186]
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Cellular component
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plasma membrane [GO:0005886]
integral to membrane [GO:0016021]
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Molecular function
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C-C chemokine receptor activity [GO:0016493]
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With
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Uniprot accession
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IntAct
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Alternative product(s)
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top
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Feature key |
Position
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Length
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Description
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Feature identifier
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| 1 |
MLSTSRSRFI |
RNTNESGEEV |
TTFFDYDYGA |
PCHKFDVKQI |
GAQLLPPLYS |
LVFIFGFVGN |
MLVVLILINC |
KKLKCLTDIY |
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| 81 |
LLNLAISDLL |
FLITLPLWAH |
SAANEWVFGN |
AMCKLFTGLY |
HIGYFGGIFF |
IILLTIDRYL |
AIVHAVFALK |
ARTVTFGVVT |
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| 161 |
SVITWLVAVF |
ASVPGIIFTK |
CQKEDSVYVC |
GPYFPRGWNN |
FHTIMRNILG |
LVLPLLIMVI |
CYSGILKTLL |
RCRNEKKRHR |
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| 241 |
AVRVIFTIMI |
VYFLFWTPYN |
IVILLNTFQE |
FFGLSNCEST |
SQLDQATQVT |
ETLGMTHCCI |
NPIIYAFVGE |
KFRRYLSVFF |
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| 321 |
RKHITKRFCK |
QCPVFYRETV |
DGVTSTNTPS |
TGEQEVSAGL |
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>sp|Q4VBL2|Q4VBL2_human Chemokine (C-C motif) receptor 2 [submitted name]
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIY
LLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVT
SVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRRYLSVFF
RKHITKRFCKQCPVFYRETVDGVTSTNTPSTGEQEVSAGL
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