(CCL2) chemokine (C-C motif) ligand 2 [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  8706
 Official symbol  CCL2
 Official name  chemokine (C-C motif) ligand 2
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 17 (NC_000017.10) :  32582295...32584221  (+)
 Map  17q11.2-q21.1
 Length  1927  nt
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Alternative name(s) and Synynom(s) top
Synonyms HSMCR30; SMC-CF; SCYA2; MGC9434; MCP1; MCP-1; MCAF; HC11; GDCF-2
Alternative name(s) small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); monocyte secretory protein JE; monocyte chemotactic protein 1, homologous to mouse Sig-je; monocyte chemotactic and activating factor; monocyte chemoattractant protein-1
External Links top
Ensembl ENSG00000108691
Entrez 6347
HGNC 10618
HPRD 01149
Comment top
Summary This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq].
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Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
AGAGGAACCG AGAGGCTGAG ACTAACCCAG AAACATCCAA TTCTCAAACT GAAGCTCGCA CTCTCGCCTC CAGCATGAAA
81  GTCTCTGCCG CCCTTCTGTG CCTGCTGCTC ATAGCAGCCA CCTTCATTCC CCAAGGGCTC GCTCAGCCAG GTAAGGCCCC
161  CTCTTCTTCT CCTTGAACCA CATTGTCTTC TCTCTGAGTT ATCATGGACC ATCCAAGCAG ACGTGGTACC CACAGTCTTG
241  CTTTAACGCT ACTTTTCCAA GATAAGGTGA CTCAGAAAAG GACAAGGGGT GAGCCCAACC ACACAGCTGC TGCTCGGCAG
321  AGCCTGAACT AGAATTCCAG CTGTGAACCC CAAATCCAGC TCCTTCCAGG ATTCCAGCTC TGGGAACACA CTCAGCGCAG
401  TTACTCCCCC AGCTGCTTCC AGCAGAGTTT GGGGATCAGG GTAATCAAAG AGAGGGTGGG TGTGTAGGCT GTTTCCAGAC
481  ACGCTGGAGA CCCAGAATCT GGTCTGTGCT TCATTCACCT TAGCTTCCAG AGACGGTGAC TCTGCAGAGG TAATGAGTAT
561  CAGGGAAACT CATGACCAGG CATAGCCTAT TCAGAGTCTA AAAGGAGGCT CATAGTGGGG CTCCCCAGCT GATCTTCCCT
641  GGTGCTGATC ATCTGGATTA TTGGTCCGTC TTAATGACAC TTGTAGGCAT TATCTAGCTT TAACAGCTCC TCCTTCTCTC
721  TGTCCATTAT CAATGTTATA TACCCATTTT ACAGCATAGG AAACTGAGTC ATTGGGTCAA AGATCACATT CTAGCTCTGA
801  GGTATAGGCA GAAGCACTGG GATTTAATGA GCTCTTTGTC TTCTCCTGCC TGCCTTTTGC TTTTTCCTCA TGACTCTTTT
881  CTGCTCTTAA GATCAGAATA ATCCAGTTCA TCCTAAAATG CTTTTTCTTT GTGGTTTATT TTCCAGATGC AATCAATGCC
961  CCAGTCACCT GCTGTTATAA CTTCACCAAT AGGAAGATCT CAGTGCAGAG GCTCGCGAGC TATAGAAGAA TCACCAGCAG
1041  CAAGTGTCCC AAAGAAGCTG TGATGTGAGT TCAGCACACC AACCTTCCCT GGCCTGAAGT TCTTCCTTGT GGAGCAAGGG
1121  ACAAGCCTCA TAAACCTAGA GTCAGAGAGT GCACTATTTA ACTTAATGTA CAAAGGTTCC CAATGGGAAA ACTGAGGCAC
1201  CAAGGGAAAA AGTGAACCCC AACATCACTC TCCACCTGGG TGCCTATTCA GAACACCCCA ATTTCTTTAG CTTGAAGTCA
1281  GGATGGCTCC ACCTGGACAC CTATAGGAGC AGTTTGCCCT GGGTTCCCTC CTTCCACCTG CGTTCCTCCT CTAGCTCCCA
1361  TGGCAGCCCT TTGGTGCAGA ATGGGCTGCA CTTCTAGACC AAAACTGCAA AGGAACTTCA TCTAACTCTG TCCTCCCTCC
1441  CCACAGCTTC AAGACCATTG TGGCCAAGGA GATCTGTGCT GACCCCAAGC AGAAGTGGGT TCAGGATTCC ATGGACCACC
1521  TGGACAAGCA AACCCAAACT CCGAAGACTT GAACACTCAC TCCACAACCC AAGAATCTGC AGCTAACTTA TTTTCCCCTA
1601  GCTTTCCCCA GACACCCTGT TTTATTTTAT TATAATGAAT TTTGTTTGTT GATGTGAAAC ATTATGCCTT AAGTAATGTT
1681  AATTCTTATT TAAGTTATTG ATGTTTTAAG TTTATCTTTC ATGGTACTAG TGTTTTTTAG ATACAGAGAC TTGGGGAAAT
1761  TGCTTTTCCT CTTGAACCAC AGTTCTACCC CTGGGATGTT TTGAGGGTCT TTGCAAGAAT CATTAATACA AAGAATTTTT
1841  TTTAACATTC CAATGCATTG CTAAAATATT ATTGTGGAAA TGAATATTTT GTAACTATTA CACCAAATAA ATATATTTTT
1921  GTACAAA
>ref|Gene_ID:6347|CCL2|NC_000017.10:32582295...32584221 (+)
AGAGGAACCGAGAGGCTGAGACTAACCCAGAAACATCCAATTCTCAAACTGAAGCTCGCACTCTCGCCTCCAGCATGAAA
GTCTCTGCCGCCCTTCTGTGCCTGCTGCTCATAGCAGCCACCTTCATTCCCCAAGGGCTCGCTCAGCCAGGTAAGGCCCC
CTCTTCTTCTCCTTGAACCACATTGTCTTCTCTCTGAGTTATCATGGACCATCCAAGCAGACGTGGTACCCACAGTCTTG
CTTTAACGCTACTTTTCCAAGATAAGGTGACTCAGAAAAGGACAAGGGGTGAGCCCAACCACACAGCTGCTGCTCGGCAG
AGCCTGAACTAGAATTCCAGCTGTGAACCCCAAATCCAGCTCCTTCCAGGATTCCAGCTCTGGGAACACACTCAGCGCAG
TTACTCCCCCAGCTGCTTCCAGCAGAGTTTGGGGATCAGGGTAATCAAAGAGAGGGTGGGTGTGTAGGCTGTTTCCAGAC
ACGCTGGAGACCCAGAATCTGGTCTGTGCTTCATTCACCTTAGCTTCCAGAGACGGTGACTCTGCAGAGGTAATGAGTAT
CAGGGAAACTCATGACCAGGCATAGCCTATTCAGAGTCTAAAAGGAGGCTCATAGTGGGGCTCCCCAGCTGATCTTCCCT
GGTGCTGATCATCTGGATTATTGGTCCGTCTTAATGACACTTGTAGGCATTATCTAGCTTTAACAGCTCCTCCTTCTCTC
TGTCCATTATCAATGTTATATACCCATTTTACAGCATAGGAAACTGAGTCATTGGGTCAAAGATCACATTCTAGCTCTGA
GGTATAGGCAGAAGCACTGGGATTTAATGAGCTCTTTGTCTTCTCCTGCCTGCCTTTTGCTTTTTCCTCATGACTCTTTT
CTGCTCTTAAGATCAGAATAATCCAGTTCATCCTAAAATGCTTTTTCTTTGTGGTTTATTTTCCAGATGCAATCAATGCC
CCAGTCACCTGCTGTTATAACTTCACCAATAGGAAGATCTCAGTGCAGAGGCTCGCGAGCTATAGAAGAATCACCAGCAG
CAAGTGTCCCAAAGAAGCTGTGATGTGAGTTCAGCACACCAACCTTCCCTGGCCTGAAGTTCTTCCTTGTGGAGCAAGGG
ACAAGCCTCATAAACCTAGAGTCAGAGAGTGCACTATTTAACTTAATGTACAAAGGTTCCCAATGGGAAAACTGAGGCAC
CAAGGGAAAAAGTGAACCCCAACATCACTCTCCACCTGGGTGCCTATTCAGAACACCCCAATTTCTTTAGCTTGAAGTCA
GGATGGCTCCACCTGGACACCTATAGGAGCAGTTTGCCCTGGGTTCCCTCCTTCCACCTGCGTTCCTCCTCTAGCTCCCA
TGGCAGCCCTTTGGTGCAGAATGGGCTGCACTTCTAGACCAAAACTGCAAAGGAACTTCATCTAACTCTGTCCTCCCTCC
CCACAGCTTCAAGACCATTGTGGCCAAGGAGATCTGTGCTGACCCCAAGCAGAAGTGGGTTCAGGATTCCATGGACCACC
TGGACAAGCAAACCCAAACTCCGAAGACTTGAACACTCACTCCACAACCCAAGAATCTGCAGCTAACTTATTTTCCCCTA
GCTTTCCCCAGACACCCTGTTTTATTTTATTATAATGAATTTTGTTTGTTGATGTGAAACATTATGCCTTAAGTAATGTT
AATTCTTATTTAAGTTATTGATGTTTTAAGTTTATCTTTCATGGTACTAGTGTTTTTTAGATACAGAGACTTGGGGAAAT
TGCTTTTCCTCTTGAACCACAGTTCTACCCCTGGGATGTTTTGAGGGTCTTTGCAAGAATCATTAATACAAAGAATTTTT
TTTAACATTCCAATGCATTGCTAAAATATTATTGTGGAAATGAATATTTTGTAACTATTACACCAAATAAATATATTTTT
GTACAAA