(MAPK3) mitogen-activated protein kinase 3 [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  8540
 Official symbol  MAPK3
 Official name  mitogen-activated protein kinase 3
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 16 (NC_000016.9) :  30125425...30134629  (-)
 Map  16p11.2
 Length  9205  nt
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Alternative name(s) and Synynom(s) top
Synonyms MGC20180; HUMKER1A; HS44KDAP; PRKM3; p44mapk; p44erk1; ERK1
Alternative name(s) extracellular signal-related kinase 1; extracellular signal-regulated kinase 1
External Links top
EC_number 2.7.11.1
Ensembl ENSG00000102882
Entrez 5595
HGNC 6877
HPRD 03479
Comment top
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq].
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Related Articles in PubMed
Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
TGGCGCGCGC GGCCCTGCGG GTGACAGGCA GGCGGGAAGG GGCGGGGCCT CGGGCGGGGC CGCCGTGGGG AGGAGGGCGG
81  TGGGAGGGGA GGAGTGGAGA TGGCGGCGGC GGCGGCTCAG GGGGGCGGGG GCGGGGAGCC CCGTAGAACC GAGGGGGTCG
161  GCCCGGGGGT CCCGGGGGAG GTGGAGATGG TGAAGGGGCA GCCGTTCGAC GTGGGCCCGC GCTACACGCA GTTGCAGTAC
241  ATCGGCGAGG GCGCGTACGG CATGGTCAGG TGAGGGGGCG TTCCGGGGGA GGGGGTGCCC TCAGGGGAGG GGGCTTCGCG
321  GGAGAGGAGG AGGAGGCGCC GAGCGCTTTC CGGGACGTGG AGACGCGGAG CGTCCCGAGG AGGCAGGAGA CTCGGGATGA
401  TCGGGAGCGT CCCAGGGAGG GGGCCCCTGA GTGCTTTCTG GGGGAGGGGG CGCTGCCTAC GTCCTCAGGG GAGCAGGCTT
481  GGAGGCTTTG AGTCCACCCT TCTGTAATGA TGGGAGGGGC ATCCGAGTGC ATGTGGGGGC CCGCGGGGAC CCTAGTGACA
561  CGGGGCGAGG CCCAGAGGAT GAGTACTCTC GGGGAGGCGA CATCCTTAGT GAAGAGGCAG TGGAGGGCCC GTTTTGGGGG
641  AAAGGGTGTC TTGGATTCCC CCTGTGAGGC AGTGCCAGGG AGCCTGGGGG AGAAGAGCCG AGATCAGGGT GGGGCAGGGC
721  TTTGGCCCCA CCACCCCAGG GGCCCAGAGA GAGATGAGGC GGCCAGGAGT GCCACCTGCA TGTTTTGGGA GGGGTCTGTG
801  AGTGCCCCCG GCCCCACCGT GTGCTCTGGG CCTCTATCCC TCTGGGACAG CCCCGCTGCC CGGATCCCTC ACCCTGGGAC
881  CCTCCCCTGC CCTGTCCATT CTCTCCTGCC CCTCCCCTGG CTGCCACCTT CCCAGTATTT GCCCCATGGT GTGTCCCCAG
961  CATCTGCACC CCCGGACCTG TCTTGGGTTA AGGAGCCTTT CCTGGGAATG GGGGCGAAGG GTTCAGGGCC AGTAGAATGG
1041  AAGGGGATTG AGGAGAGGGG AAGTCAGTGA GCGGTCAGTC TCTTCCTCTG TTTGTAAAGT CACCGAAGGG CCGCCTGGCT
1121  GGTCCCCAGC TTTCTCTCTG GAGATCCCAG GCCTCCACAG CAGGAAGGAA CCAGCATTGT TTATGATTTG ACCAGAGCCA
1201  GCTCCTGCTC TCTCCCCTCC CTGCCAAGGC CTGGGTGGGG CCACCAGGCC CGGACTCCCC CTTTGTAAGG CCACAGCAGC
1281  AGCCTCTCTC CGGTCCCCTC AGCTCGGCCT ATGACCACGT GCGCAAGACT CGCGTGGCCA TCAAGAAGAT CAGCCCCTTC
1361  GAACATCAGA CCTACTGCCA GCGCACGCTC CGGGAGATCC AGATCCTGCT GCGCTTCCGC CATGAGAATG TCATCGGCAT
1441  CCGAGACATT CTGCGGGCGT CCACCCTGGA AGCCATGAGA GATGTGTATC CTTCACCTTG GCCAGTCGGC TGGTCAGGCA
1521  CGGCCTCGCA GCTGGGCTGG GGACCCGTTG CTTGGTTTCT GTTTCCATCT TACCCACCAC CCTCCAAAAC AAACCCAGTA
1601  AAATAAACTT TCCTGCAGAG GGGAAGCCAC AGTGTAACAG GACTTGGAGA CCTCTGATGA ACCCAGGCCT GCAGCGGCCC
1681  AGGCAGTATG GCCTCGAGCA AGTGGGTTCT CTGCTCTGTG CCCCAGGGGG AAGGGCTAGG CAGGATGGTC TCTATGGGAG
1761  TGGTGTCTTC TGACGTCGGC AGTTCTGAGA CATGACCTGG CCTCTGCCCA CAGTCACTTC TTGCTAAGGA ATGGATGATT
1841  CTTTCCTCTC TTTCCTCCTT GCCCAGACCG GAAGGGAGAC AGGGAGAAAG AAAACTGTCA GCTGGGCGTG GTGGCTCACG
1921  CCTGTAATCC CAGCACTTTG GGAGGCTGAG GTGGGAGATT ACCTGAGGTC AGTAGTTGGA GACCAGCCTG GCCAACATGG
2001  TTAAACCCCA TCTCTACTAA AAATACAAAA AAATTAGCGG GGCATGGTGG TGCAAGCCTG TAATCCCAGC TACTTGGGAG
2081  GCAGAGGTAG GAGAATCGCT TGAACCCAGG AGCTGGAGGT TGCAGTGAGC CAAGATCGTG CCACTGCACT CCAGCCTGGG
2161  TGACAGAGCG AGACTCTGTC TCAAAACTAA ACAAAAACAA AAAACTGCCT TTCTTGAGGG CCTGCTGTGT GTCAGGTACT
2241  ATACATGCCC AATGCTTTTT TTTTTCTATT ACACCTCCCA ACTACCCTAT GAGATGGGCT TTTCAGCTTC ATTTCAAAGA
2321  TGAGGGGTGG AGTGCAATGG CTCACATCTG TAGTCCCAAC ACTTTGGGAG GCTAAGACCA GAGGATCACT GGAGGCCAGG
2401  AGTTCAAGAC CAGCCTGGGC AGCATAGTGA GACCCCACCT CTACAAAAAA TTTAAAAATT ATCCAGGTTT GGTGGTACAC
2481  GACTATAGTC CCAGCTACTT GGGAGGCTGA GGCAGGAGGA TGGCTTGAGC TTAGGAGTTC GAGGCTGCAG TGAGCTATGA
2561  TTGTGCTACT GCACTCTAGC CTGGGGGACA GAGCGTGACC CTGTCAAAAA AAAAAAAAAA AAAAAAGATG AGGAAGCTAA
2641  GGCTCAGAAA ACCTAAAATC AAGTGTTTCT GTTGCTGTCT CCTCCTCTCC TCCCCCAGAT GGGAACTTGT CCTTCTTCTT
2721  AGGACTTCTC ACTCAGAGCC ACACCCTAAT CACCTGTGGA CTTGCACCTT GCCCAGGGAG GGACAGCCTA GCCTTGGCTG
2801  TCCTCCCCCA ATACTGCTTT CCTAGTTTGC TGTCCACTTC CTGTCTGGCT CTCCTTAGCA ACTTATGACA CCTGTCACTT
2881  CTTCCCTGCC CCACCCACCC ACTCTCAGTC CCAGCCCTCC ACCCAAGAGT GGGGATTTGT ACTGAGGTGT CTGCAACCCC
2961  CACCACAAAC TGTGGACAGG AAATCTCCGT GCTCACCCCC AGCTCGCTGT GTGATCTGAA GCAAGTCACT GCGTCTCGCT
3041  GGGCCTCCCC AGCCCTAAAA CAGCAGGGCT GGTCCACATA TTCTCTGAAG ACCCTTTCAA GGCTGATTCT TGTTTTCTTT
3121  GTTTTTTGTT TGTTTGTTTT TAGATGGAGT CTCCCTCTGT TGCCCAGGCT AGAGTGCAGT GGCTCAATCT CAGCTCACGG
3201  CAACCTCCAC CTCCCAGGTT CAAGCTATTC TCCTGCCTCA GCCTTCCAAG TAGCTGGGAC TACAGGCGCC TGCCACCACG
3281  CCCGGCTAAT TTTTGTATTT TCAGTAGATG CGGGGTTTCG CCCTGTTCAC CAGGCTGGCG TCAAACTCCT GACCTCAGGT
3361  CATCAACCCA CCTTGGCCTC CTGAAGAGCT GGGATTACAG GCATGAGCCA CCATGCCTGG TCTCAAGGCA GATTCTAAAA
3441  GACAGCCCTG ACTTATTTTT CTAGAGACAA GCCAAACAGC ATTTGTGGAT TTATTTATTT ATTTACGCAT AAGCTTTTTT
3521  GTATCTTCAA ATAGAAAAAG ACATTTTACT CCTCCATCTT CTGAGGTATG GCCAAGCACT CTCCTTTGAG TGGGAGTGTG
3601  CTGTTGGGAG TGTCTCCTCA TTTTTCTTGC ACAAACCATT CCCATAAGGC AGGCATTTAT TTTTAAGCAA ACATTTATTG
3681  CATGCCAGAT GGTGTTCATA CATTATCTCA TTTAACTCCC TCAACAGCCA TGTGACTCAG GCATTCATAT TAGTAATAAT
3761  AGTTCATGTT TGCCTAGCAC TCACAACTTG CCAAGCACTG GGCTGACAGC TTTACATGCG CCATCTCATC TAGTCTTCAC
3841  AACCACCCTC AAAAGAACCA TTATTTCATG GCTTGCACCT GTAATTTCCA GCACTTTGGG AGGCCGAGGT GGAAGGAACA
3921  CTTGAACCCA TGAGTTCAAG ACCTGCCTGG GCAACAGAGC AAGAGCCCAT CTCCACAAAA AGAAAACAAA CAAACAAACA
4001  AAAAAACATT ATTTCCCCTA CATACCAGAT GAGAAAGTTG AGGCACAGAC AGGTTGAGAT CCTAAAGCCA GTGAGTAGTA
4081  GAGAGGAGAT TTCAGACATC CATGGGTTAA CTCCAGAGTT GCTGCTCTTT TTGTAGGTTT TTTTTTTTTT TTAATTTATT
4161  TATTTTTGAG ACAGAGTCTC ACTCTGTCAT CCGGGCTGCA GTGCAGTGAC ACAATCTTGG CTCACTGCAA CATCTGCCTC
4241  CTGGGTTCAA GTGATTCTCG TGCTGCAGCC TCCTGAGTAG CTGGGATTAC AGGCACATGC CGCCGTGCCC AGTTAATTTT
4321  GCTATTTTTA GTAGAGACAG GGTTTTGCCA TGTTGCCCAG GCTGGTGGTC TCAAACTCCT GGCCTCAAGC AGTCCTCCCG
4401  CCTCAGCCTC CCAAAGTGCT GGGATTACAG GTGTGAGCCA CCACTCCTGG CCCAAGTTGC TGCTCTTAAC TGTGAAGTTC
4481  TCCTGCCTCC CACAGTTTAT TATTATCCCC GTTTCCCCGG TAGGGAAACT GAGGCCTCAG AAATGAAGCC CCTTGCTCAG
4561  GATCAGCAAC TGTGATGCAA CAGAGGCTCA GAGCCCTGCC GCTGGGTAAT GGCAGCAGCT TCCCCAGCTG GTGGTGCAGG
4641  TTGGCAGATC TATTGAGTCC CAGGGGCCCT GGCTGGAGGA GGTGTGCAGC CTCGCCTTCA GAGCCTGTTT TCCTTAACCA
4721  AGTGCCTCCC ACTGCCCCCT GCCTGGGGGG GTCTGCGGAA CCATCCTCAG CTACATTGTG CAGGACCTGA TGGAGACTGA
4801  CCTGTACAAG TTGCTGAAAA GCCAGCAGCT GAGCAATGAC CATATCTGCT ACTTCCTCTA CCAGATCCTG CGGGGCCTCA
4881  AGTACATCCA CTCCGCCAAC GTGCTCCACC GAGATCTAAA GCCCTCCAAC CTGCTCATCA ACACCACCTG CGACCTTAAG
4961  GTCAGAGGGT TGGGCACCTG TCCCCTCCTC CCCCAGGGTC TGGGGCTTCC AGTGACCAGT AGAAGAAGCC TTGGGCAGGA
5041  GAACATTGCA AGCAAAGGGA ACAGTGGAGG CAAAGACAAG GGGGCGTGAC TGCTTAGGCT GCAGAGGCCT TGAGCGCCGA
5121  GCTTAGCAGC TAGGTCTGAT TCCAGATTTG TGATTTCGGC CTGGCCCGGA TTGCCGATCC TGAGCATGAC CACACCGGCT
5201  TCCTGACGGA GTATGTGGCT ACGCGCTGGT ACCGGGCCCC AGAGATCATG CTGAACTCCA AGGTAGGAGG GGCTGCCCAC
5281  TCCTGAAAGG AACGGACCAG TTCCCAGGAA GCCCTGGAGC TACCTCTGAG CCAGACACTG ACCCCCATGA CACAGGAATT
5361  CTACCCTCTG GGCCTTGGGC TCTGCAAGGA AGCTGAGCAT TGAGCCCTCC AGGCCTCTGC CTTCTGCCTG GTGTTGGATC
5441  TAACTTGGAG GTGGTGGCCT GGCGCAGACA ACAGGACCCT GTTGAGGCTG GCCCAGGAGC TCACCACTTC CTCCTCTCCC
5521  CCAGGGCTAT ACCAAGTCCA TCGACATCTG GTCTGTGGGC TGCATTCTGG CTGAGATGCT CTCTAACCGG CCCATCTTCC
5601  CTGGCAAGCA CTACCTGGAT CAGCTCAACC ACATTCTGGG TGAGGGAGGC CCGGCTGGCT GAGTTGGGGA TGATTAGCTT
5681  TTCCGAGGTG AGATTTCTCG AGAGTCCAAG TCAGGGATAC CACCACGTGT GGGGTGCCTC CAGCATCTCA TGGTATCTCA
5761  ATGAGGTATA GATATTATCC CCATTGGATA GATGGGAAAA GCAAGGCTAA GTCCCACACC TGAGGAGGCA CCAGACCTAG
5841  GATTTGAGCC TCGGTCTGCC TGAACCCAGC CCCCTTGCTC TGCACCACCA TGCTAATGAC TAGGAGGTGA CTGAGGGATT
5921  GGCATGGGTT GCTGGGCTGG GGGGTCTTGT TCTTGCCTTG TTGCCTATTC TGTTCCCAGA AAGAAAGAGG TGATCATTTA
6001  CCAAGTCACC TCCTTATCCA CAGGCATCCT GGGCTCCCCA TCCCAGGAGG ACCTGAATTG TATCATCAAC ATGAAGGCCC
6081  GAAACTACCT ACAGTCTCTG CCCTCCAAGA CCAAGGTGGC TTGGGCCAAG CTTTTCCCCA AGTCAGACTC CAAAGGTTCG
6161  AGAGACATGA GGGTGGGTGT GGGATAAACC TTGGGTGTCG TGGAGGGTGT GTGAGCCCAG CAGCCGCTGG AGGAGACAGG
6241  CAAAGCAATG CTTCTCGGAG CTCCTCCAGT CTTCCCTGTG ACCCCTGACT CCTGCCCTTC CATAGCCCTT GACCTGCTGG
6321  ACCGGATGTT AACCTTTAAC CCCAATAAAC GGATCACAGT GGAGGAAGCG CTGGCTCACC CCTACCTGGA GCAGTACTAT
6401  GACCCGACGG ATGAGGTGGG CCAGTCCCCA GCAGCAGTGG GGCTGGGGGC AGGGGAGCAG GGGGGCACGT AGGCATCCCC
6481  CATGCCAGGC CTGAGCCTTG CTGTCTCTAC CACCCCAGCC AGTGGCCGAG GAGCCCTTCA CCTTCGCCAT GGAGCTGGAT
6561  GACCTACCTA AGGAGCGGCT GAAGGAGCTC ATCTTCCAGG AGACAGCACG CTTCCAGCCC GGAGTGCTGG AGGCCCCCTA
6641  GCCCAGACAG ACATCTCTGC ACCCTGGGGC CTGGTGAGTG TCTCCATGGC CCACACATGG ACACCCTGAT ACTAAATATC
6721  TATATCTGTA TATCTATATC TATATCTATC TGTACATGCC TCCATACAGC AGCAAGCTTA CCCCACACCC ATGGTCAATG
6801  TGTCTGGTGA CAACAGAAGT GCCCAGGGGG CTGGGTGTGG TGGCTCATGC CTGGAATCCC AGCACTTTGG GAGACTGAGA
6881  CTGAGAGGAG TGGATCACCT GAGGGTCAGG AGTTTGAGAC CAGCCTGGCC TGCATGGTGA AATCCCATCT ATACTAAAAA
6961  TACAAAAATT AGCCGGGCAC AGTGGGTCAC TCTGGTAATC CCAGCACTTT GGGAGGCTGA GGCAAGTGGA TCACCTGAGG
7041  TCAGGAGTCC GAGACCAGCC TGCCTGGCCA ACGTGGTGAA ACCCTGTCTC TACTAAAAAT ACAAAAATTA GCCGGGCACG
7121  TAGGCATGCG CTTCTAGTCC CAGCTACTCA GGAGGCTGTG GTGGGAGGAC TGCTTGAACC TGGGAGGCGG AGGTTGCACC
7201  ACTGTACTCC AGCCTGGGCA ACAGTGAGAC TCTCTCAAAA AAAAAAAAAA AAGGGCTGGG CACAGTGGCT CATGCCTGTA
7281  ATCCCAGCAC TTTGGGAGGC CGAGGTGGGT GGATCACAAG GTCAAGAGTT GAGACCAGCC TGGCCAACAT GGTGAAACCC
7361  GGTCTCTACT GTAAAGAATA CAAAAATGAG CTGGGTGTGG TGGCACATGC CTATAATCCC AGCTACTCAG GAGGCTGAGG
7441  CAGGAGAATT GCTTGAACCC AGGAGGCAGA GGTTGCAGTG AGCCGAGATC GCACCACTGC ACTCCAGCCT GGACTACAGA
7521  GCAAGACTCC ATCTCAAAAA AAAAAAAAAA AATGCCCAAG GCTGCCCAGA CTGGTGGCCC ACCGAGTCCT CCAGCCCCAA
7601  ATGTCTCTGC CTGTCAACAC CTTGCATCCT CCAGCCCCAC AAGCCATTCT AATCTCCTTC TAGGAACAGA ACTGGCAAAG
7681  AGGCAAGAGG TCACTGAGGG CCTCTGTCAC CCAGGTGAGG ACCTGAGCCA AGCTTCAGCT CTGGGTGTGG CAGAAGCAGG
7761  TGGGGCCATG ATTGCTTTGG GAGGGGCCCA GCAGCGCCCA GCCTGACCCA GATTGCCAGG CCTCCTCACA CCTGCTGCCA
7841  GATCAGCAGT TCACATAGCT GTGGGGACCC CACTGGCCTG CCCCCACCCA CGCTGCCTCC TTGCCTCCTC CGGTCTCTTC
7921  CTGTCTTCAG CCAGGTGTGG CCTGATAGAA AGAAGGCATG CGCACCTGGG CTCAAACTCC AGCTGTGCCA CTTAGTAAGT
8001  GCTGTGTGAT ATTGGGCAAG GCACCTCACC TCTCGGCGCC TCAGTTTCCG GAGTCAATCT ATTTATCTTT TTTTTTGGTT
8081  TTGTTTTTTT GAGACAGTGT CTCGCTCTGT CACCCAGGCT GGAATGCAGT GGTGCAATCA TAGCTCACTG CAGCCTCAAA
8161  ACTCCTGGGT GCAAGGGATC CTCCCAGCTA GCTGGACGAG CCATTGCAAC CGGCTAATTT TTTTTTTTTT TTTTTGTGGA
8241  GCTGGGGTCT TGCTATGTTG CCCAGGCCAG TCTCAAACTC CTGGGCTCAA GCGATCCACC ACCTCAGCTT CTCAAAGTGC
8321  TGGGATTATA GGCGTGAGCC ACTGTGCCCG GCCGAGACAG TTCTAATAAT GAAAGCATAA AGCCCTAAGC ATTGTTCTAA
8401  GAGGTTTACA TGTATTAATT CCTTTAATCT TACAGCAGTA CCTCAAGCTA GGTACTATTA TTATCTCCAT TTACAGATAA
8481  GGAAACTGAG ACCCAGCCTA TCCAGCTGTG AGGGTGAAAT GAGAGATGTT GAGGTCAGGG CTCCAGTGGG TCTGCCCGGG
8561  GGGTGCTAAC GACTCCTCTT CTGCCTGCTT CTCTCTTTAG GACCTGCCTC CTGCCTGCCC CTCTCCCGCC AGACTGTTAG
8641  AAAATGGACA CTGTGCCCAG CCCGGACCTT GGCAGCCCAG GCCGGGGTGG AGCATGGGCC TGGCCACCTC TCTCCTTTGC
8721  TGAGGCCTCC AGCTTCAGGC AGGCCAAGGC CTTCTCCTCC CCACCCGCCC TCCCCACGGG GCCTCGGGAC CTCAGGTGGC
8801  CCCAGTTCAA TCTCCCGCTG CTGCTGCTGC GCCCTTACCT TCCCCAGCGT CCCAGTCTCT GGCAGTTCTG GAATGGAAGG
8881  GTTCTGGCTG CCCCAACCTG CTGAAGGGCA GAGGTGGAGG GTGGGGGGCG CTGAGTAGGG ACTCAGGGCC ATGCCTGCCC
8961  CCCTCATCTC ATTCAAACCC CACCCTAGTT TCCCTGAAGG AACATTCCTT AGTCTCAAGG GCTAGCATCC CTGAGGAGCC
9041  AGGCCGGGCC GAATCCCCTC CCTGTCAAAG CTGTCACTTC GCGTGCCCTC GCTGCTTCTG TGTGTGGTGA GCAGAAGTGG
9121  AGCTGGGGGG CGTGGAGAGC CCGGCGCCCC TGCCACCTCC CTGACCCGTC TAATATATAA ATATAGAGAT GTGTCTATGG
9201  CTGAC
>ref|Gene_ID:5595|MAPK3|NC_000016.9:30125425...30134629 (-)
TGGCGCGCGCGGCCCTGCGGGTGACAGGCAGGCGGGAAGGGGCGGGGCCTCGGGCGGGGCCGCCGTGGGGAGGAGGGCGG
TGGGAGGGGAGGAGTGGAGATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTCG
GCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCGCGCTACACGCAGTTGCAGTAC
ATCGGCGAGGGCGCGTACGGCATGGTCAGGTGAGGGGGCGTTCCGGGGGAGGGGGTGCCCTCAGGGGAGGGGGCTTCGCG
GGAGAGGAGGAGGAGGCGCCGAGCGCTTTCCGGGACGTGGAGACGCGGAGCGTCCCGAGGAGGCAGGAGACTCGGGATGA
TCGGGAGCGTCCCAGGGAGGGGGCCCCTGAGTGCTTTCTGGGGGAGGGGGCGCTGCCTACGTCCTCAGGGGAGCAGGCTT
GGAGGCTTTGAGTCCACCCTTCTGTAATGATGGGAGGGGCATCCGAGTGCATGTGGGGGCCCGCGGGGACCCTAGTGACA
CGGGGCGAGGCCCAGAGGATGAGTACTCTCGGGGAGGCGACATCCTTAGTGAAGAGGCAGTGGAGGGCCCGTTTTGGGGG
AAAGGGTGTCTTGGATTCCCCCTGTGAGGCAGTGCCAGGGAGCCTGGGGGAGAAGAGCCGAGATCAGGGTGGGGCAGGGC
TTTGGCCCCACCACCCCAGGGGCCCAGAGAGAGATGAGGCGGCCAGGAGTGCCACCTGCATGTTTTGGGAGGGGTCTGTG
AGTGCCCCCGGCCCCACCGTGTGCTCTGGGCCTCTATCCCTCTGGGACAGCCCCGCTGCCCGGATCCCTCACCCTGGGAC
CCTCCCCTGCCCTGTCCATTCTCTCCTGCCCCTCCCCTGGCTGCCACCTTCCCAGTATTTGCCCCATGGTGTGTCCCCAG
CATCTGCACCCCCGGACCTGTCTTGGGTTAAGGAGCCTTTCCTGGGAATGGGGGCGAAGGGTTCAGGGCCAGTAGAATGG
AAGGGGATTGAGGAGAGGGGAAGTCAGTGAGCGGTCAGTCTCTTCCTCTGTTTGTAAAGTCACCGAAGGGCCGCCTGGCT
GGTCCCCAGCTTTCTCTCTGGAGATCCCAGGCCTCCACAGCAGGAAGGAACCAGCATTGTTTATGATTTGACCAGAGCCA
GCTCCTGCTCTCTCCCCTCCCTGCCAAGGCCTGGGTGGGGCCACCAGGCCCGGACTCCCCCTTTGTAAGGCCACAGCAGC
AGCCTCTCTCCGGTCCCCTCAGCTCGGCCTATGACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTC
GAACATCAGACCTACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTCATCGGCAT
CCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTGTATCCTTCACCTTGGCCAGTCGGCTGGTCAGGCA
CGGCCTCGCAGCTGGGCTGGGGACCCGTTGCTTGGTTTCTGTTTCCATCTTACCCACCACCCTCCAAAACAAACCCAGTA
AAATAAACTTTCCTGCAGAGGGGAAGCCACAGTGTAACAGGACTTGGAGACCTCTGATGAACCCAGGCCTGCAGCGGCCC
AGGCAGTATGGCCTCGAGCAAGTGGGTTCTCTGCTCTGTGCCCCAGGGGGAAGGGCTAGGCAGGATGGTCTCTATGGGAG
TGGTGTCTTCTGACGTCGGCAGTTCTGAGACATGACCTGGCCTCTGCCCACAGTCACTTCTTGCTAAGGAATGGATGATT
CTTTCCTCTCTTTCCTCCTTGCCCAGACCGGAAGGGAGACAGGGAGAAAGAAAACTGTCAGCTGGGCGTGGTGGCTCACG
CCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGAGATTACCTGAGGTCAGTAGTTGGAGACCAGCCTGGCCAACATGG
TTAAACCCCATCTCTACTAAAAATACAAAAAAATTAGCGGGGCATGGTGGTGCAAGCCTGTAATCCCAGCTACTTGGGAG
GCAGAGGTAGGAGAATCGCTTGAACCCAGGAGCTGGAGGTTGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGG
TGACAGAGCGAGACTCTGTCTCAAAACTAAACAAAAACAAAAAACTGCCTTTCTTGAGGGCCTGCTGTGTGTCAGGTACT
ATACATGCCCAATGCTTTTTTTTTTCTATTACACCTCCCAACTACCCTATGAGATGGGCTTTTCAGCTTCATTTCAAAGA
TGAGGGGTGGAGTGCAATGGCTCACATCTGTAGTCCCAACACTTTGGGAGGCTAAGACCAGAGGATCACTGGAGGCCAGG
AGTTCAAGACCAGCCTGGGCAGCATAGTGAGACCCCACCTCTACAAAAAATTTAAAAATTATCCAGGTTTGGTGGTACAC
GACTATAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGGATGGCTTGAGCTTAGGAGTTCGAGGCTGCAGTGAGCTATGA
TTGTGCTACTGCACTCTAGCCTGGGGGACAGAGCGTGACCCTGTCAAAAAAAAAAAAAAAAAAAAAGATGAGGAAGCTAA
GGCTCAGAAAACCTAAAATCAAGTGTTTCTGTTGCTGTCTCCTCCTCTCCTCCCCCAGATGGGAACTTGTCCTTCTTCTT
AGGACTTCTCACTCAGAGCCACACCCTAATCACCTGTGGACTTGCACCTTGCCCAGGGAGGGACAGCCTAGCCTTGGCTG
TCCTCCCCCAATACTGCTTTCCTAGTTTGCTGTCCACTTCCTGTCTGGCTCTCCTTAGCAACTTATGACACCTGTCACTT
CTTCCCTGCCCCACCCACCCACTCTCAGTCCCAGCCCTCCACCCAAGAGTGGGGATTTGTACTGAGGTGTCTGCAACCCC
CACCACAAACTGTGGACAGGAAATCTCCGTGCTCACCCCCAGCTCGCTGTGTGATCTGAAGCAAGTCACTGCGTCTCGCT
GGGCCTCCCCAGCCCTAAAACAGCAGGGCTGGTCCACATATTCTCTGAAGACCCTTTCAAGGCTGATTCTTGTTTTCTTT
GTTTTTTGTTTGTTTGTTTTTAGATGGAGTCTCCCTCTGTTGCCCAGGCTAGAGTGCAGTGGCTCAATCTCAGCTCACGG
CAACCTCCACCTCCCAGGTTCAAGCTATTCTCCTGCCTCAGCCTTCCAAGTAGCTGGGACTACAGGCGCCTGCCACCACG
CCCGGCTAATTTTTGTATTTTCAGTAGATGCGGGGTTTCGCCCTGTTCACCAGGCTGGCGTCAAACTCCTGACCTCAGGT
CATCAACCCACCTTGGCCTCCTGAAGAGCTGGGATTACAGGCATGAGCCACCATGCCTGGTCTCAAGGCAGATTCTAAAA
GACAGCCCTGACTTATTTTTCTAGAGACAAGCCAAACAGCATTTGTGGATTTATTTATTTATTTACGCATAAGCTTTTTT
GTATCTTCAAATAGAAAAAGACATTTTACTCCTCCATCTTCTGAGGTATGGCCAAGCACTCTCCTTTGAGTGGGAGTGTG
CTGTTGGGAGTGTCTCCTCATTTTTCTTGCACAAACCATTCCCATAAGGCAGGCATTTATTTTTAAGCAAACATTTATTG
CATGCCAGATGGTGTTCATACATTATCTCATTTAACTCCCTCAACAGCCATGTGACTCAGGCATTCATATTAGTAATAAT
AGTTCATGTTTGCCTAGCACTCACAACTTGCCAAGCACTGGGCTGACAGCTTTACATGCGCCATCTCATCTAGTCTTCAC
AACCACCCTCAAAAGAACCATTATTTCATGGCTTGCACCTGTAATTTCCAGCACTTTGGGAGGCCGAGGTGGAAGGAACA
CTTGAACCCATGAGTTCAAGACCTGCCTGGGCAACAGAGCAAGAGCCCATCTCCACAAAAAGAAAACAAACAAACAAACA
AAAAAACATTATTTCCCCTACATACCAGATGAGAAAGTTGAGGCACAGACAGGTTGAGATCCTAAAGCCAGTGAGTAGTA
GAGAGGAGATTTCAGACATCCATGGGTTAACTCCAGAGTTGCTGCTCTTTTTGTAGGTTTTTTTTTTTTTTTAATTTATT
TATTTTTGAGACAGAGTCTCACTCTGTCATCCGGGCTGCAGTGCAGTGACACAATCTTGGCTCACTGCAACATCTGCCTC
CTGGGTTCAAGTGATTCTCGTGCTGCAGCCTCCTGAGTAGCTGGGATTACAGGCACATGCCGCCGTGCCCAGTTAATTTT
GCTATTTTTAGTAGAGACAGGGTTTTGCCATGTTGCCCAGGCTGGTGGTCTCAAACTCCTGGCCTCAAGCAGTCCTCCCG
CCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACTCCTGGCCCAAGTTGCTGCTCTTAACTGTGAAGTTC
TCCTGCCTCCCACAGTTTATTATTATCCCCGTTTCCCCGGTAGGGAAACTGAGGCCTCAGAAATGAAGCCCCTTGCTCAG
GATCAGCAACTGTGATGCAACAGAGGCTCAGAGCCCTGCCGCTGGGTAATGGCAGCAGCTTCCCCAGCTGGTGGTGCAGG
TTGGCAGATCTATTGAGTCCCAGGGGCCCTGGCTGGAGGAGGTGTGCAGCCTCGCCTTCAGAGCCTGTTTTCCTTAACCA
AGTGCCTCCCACTGCCCCCTGCCTGGGGGGGTCTGCGGAACCATCCTCAGCTACATTGTGCAGGACCTGATGGAGACTGA
CCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAATGACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCA
AGTACATCCACTCCGCCAACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCATCAACACCACCTGCGACCTTAAG
GTCAGAGGGTTGGGCACCTGTCCCCTCCTCCCCCAGGGTCTGGGGCTTCCAGTGACCAGTAGAAGAAGCCTTGGGCAGGA
GAACATTGCAAGCAAAGGGAACAGTGGAGGCAAAGACAAGGGGGCGTGACTGCTTAGGCTGCAGAGGCCTTGAGCGCCGA
GCTTAGCAGCTAGGTCTGATTCCAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCT
TCCTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAGGTAGGAGGGGCTGCCCAC
TCCTGAAAGGAACGGACCAGTTCCCAGGAAGCCCTGGAGCTACCTCTGAGCCAGACACTGACCCCCATGACACAGGAATT
CTACCCTCTGGGCCTTGGGCTCTGCAAGGAAGCTGAGCATTGAGCCCTCCAGGCCTCTGCCTTCTGCCTGGTGTTGGATC
TAACTTGGAGGTGGTGGCCTGGCGCAGACAACAGGACCCTGTTGAGGCTGGCCCAGGAGCTCACCACTTCCTCCTCTCCC
CCAGGGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCTAACCGGCCCATCTTCC
CTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGTGAGGGAGGCCCGGCTGGCTGAGTTGGGGATGATTAGCTT
TTCCGAGGTGAGATTTCTCGAGAGTCCAAGTCAGGGATACCACCACGTGTGGGGTGCCTCCAGCATCTCATGGTATCTCA
ATGAGGTATAGATATTATCCCCATTGGATAGATGGGAAAAGCAAGGCTAAGTCCCACACCTGAGGAGGCACCAGACCTAG
GATTTGAGCCTCGGTCTGCCTGAACCCAGCCCCCTTGCTCTGCACCACCATGCTAATGACTAGGAGGTGACTGAGGGATT
GGCATGGGTTGCTGGGCTGGGGGGTCTTGTTCTTGCCTTGTTGCCTATTCTGTTCCCAGAAAGAAAGAGGTGATCATTTA
CCAAGTCACCTCCTTATCCACAGGCATCCTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCC
GAAACTACCTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGACTCCAAAGGTTCG
AGAGACATGAGGGTGGGTGTGGGATAAACCTTGGGTGTCGTGGAGGGTGTGTGAGCCCAGCAGCCGCTGGAGGAGACAGG
CAAAGCAATGCTTCTCGGAGCTCCTCCAGTCTTCCCTGTGACCCCTGACTCCTGCCCTTCCATAGCCCTTGACCTGCTGG
ACCGGATGTTAACCTTTAACCCCAATAAACGGATCACAGTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTAT
GACCCGACGGATGAGGTGGGCCAGTCCCCAGCAGCAGTGGGGCTGGGGGCAGGGGAGCAGGGGGGCACGTAGGCATCCCC
CATGCCAGGCCTGAGCCTTGCTGTCTCTACCACCCCAGCCAGTGGCCGAGGAGCCCTTCACCTTCGCCATGGAGCTGGAT
GACCTACCTAAGGAGCGGCTGAAGGAGCTCATCTTCCAGGAGACAGCACGCTTCCAGCCCGGAGTGCTGGAGGCCCCCTA
GCCCAGACAGACATCTCTGCACCCTGGGGCCTGGTGAGTGTCTCCATGGCCCACACATGGACACCCTGATACTAAATATC
TATATCTGTATATCTATATCTATATCTATCTGTACATGCCTCCATACAGCAGCAAGCTTACCCCACACCCATGGTCAATG
TGTCTGGTGACAACAGAAGTGCCCAGGGGGCTGGGTGTGGTGGCTCATGCCTGGAATCCCAGCACTTTGGGAGACTGAGA
CTGAGAGGAGTGGATCACCTGAGGGTCAGGAGTTTGAGACCAGCCTGGCCTGCATGGTGAAATCCCATCTATACTAAAAA
TACAAAAATTAGCCGGGCACAGTGGGTCACTCTGGTAATCCCAGCACTTTGGGAGGCTGAGGCAAGTGGATCACCTGAGG
TCAGGAGTCCGAGACCAGCCTGCCTGGCCAACGTGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCACG
TAGGCATGCGCTTCTAGTCCCAGCTACTCAGGAGGCTGTGGTGGGAGGACTGCTTGAACCTGGGAGGCGGAGGTTGCACC
ACTGTACTCCAGCCTGGGCAACAGTGAGACTCTCTCAAAAAAAAAAAAAAAAGGGCTGGGCACAGTGGCTCATGCCTGTA
ATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACAAGGTCAAGAGTTGAGACCAGCCTGGCCAACATGGTGAAACCC
GGTCTCTACTGTAAAGAATACAAAAATGAGCTGGGTGTGGTGGCACATGCCTATAATCCCAGCTACTCAGGAGGCTGAGG
CAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGACTACAGA
GCAAGACTCCATCTCAAAAAAAAAAAAAAAAATGCCCAAGGCTGCCCAGACTGGTGGCCCACCGAGTCCTCCAGCCCCAA
ATGTCTCTGCCTGTCAACACCTTGCATCCTCCAGCCCCACAAGCCATTCTAATCTCCTTCTAGGAACAGAACTGGCAAAG
AGGCAAGAGGTCACTGAGGGCCTCTGTCACCCAGGTGAGGACCTGAGCCAAGCTTCAGCTCTGGGTGTGGCAGAAGCAGG
TGGGGCCATGATTGCTTTGGGAGGGGCCCAGCAGCGCCCAGCCTGACCCAGATTGCCAGGCCTCCTCACACCTGCTGCCA
GATCAGCAGTTCACATAGCTGTGGGGACCCCACTGGCCTGCCCCCACCCACGCTGCCTCCTTGCCTCCTCCGGTCTCTTC
CTGTCTTCAGCCAGGTGTGGCCTGATAGAAAGAAGGCATGCGCACCTGGGCTCAAACTCCAGCTGTGCCACTTAGTAAGT
GCTGTGTGATATTGGGCAAGGCACCTCACCTCTCGGCGCCTCAGTTTCCGGAGTCAATCTATTTATCTTTTTTTTTGGTT
TTGTTTTTTTGAGACAGTGTCTCGCTCTGTCACCCAGGCTGGAATGCAGTGGTGCAATCATAGCTCACTGCAGCCTCAAA
ACTCCTGGGTGCAAGGGATCCTCCCAGCTAGCTGGACGAGCCATTGCAACCGGCTAATTTTTTTTTTTTTTTTTTGTGGA
GCTGGGGTCTTGCTATGTTGCCCAGGCCAGTCTCAAACTCCTGGGCTCAAGCGATCCACCACCTCAGCTTCTCAAAGTGC
TGGGATTATAGGCGTGAGCCACTGTGCCCGGCCGAGACAGTTCTAATAATGAAAGCATAAAGCCCTAAGCATTGTTCTAA
GAGGTTTACATGTATTAATTCCTTTAATCTTACAGCAGTACCTCAAGCTAGGTACTATTATTATCTCCATTTACAGATAA
GGAAACTGAGACCCAGCCTATCCAGCTGTGAGGGTGAAATGAGAGATGTTGAGGTCAGGGCTCCAGTGGGTCTGCCCGGG
GGGTGCTAACGACTCCTCTTCTGCCTGCTTCTCTCTTTAGGACCTGCCTCCTGCCTGCCCCTCTCCCGCCAGACTGTTAG
AAAATGGACACTGTGCCCAGCCCGGACCTTGGCAGCCCAGGCCGGGGTGGAGCATGGGCCTGGCCACCTCTCTCCTTTGC
TGAGGCCTCCAGCTTCAGGCAGGCCAAGGCCTTCTCCTCCCCACCCGCCCTCCCCACGGGGCCTCGGGACCTCAGGTGGC
CCCAGTTCAATCTCCCGCTGCTGCTGCTGCGCCCTTACCTTCCCCAGCGTCCCAGTCTCTGGCAGTTCTGGAATGGAAGG
GTTCTGGCTGCCCCAACCTGCTGAAGGGCAGAGGTGGAGGGTGGGGGGCGCTGAGTAGGGACTCAGGGCCATGCCTGCCC
CCCTCATCTCATTCAAACCCCACCCTAGTTTCCCTGAAGGAACATTCCTTAGTCTCAAGGGCTAGCATCCCTGAGGAGCC
AGGCCGGGCCGAATCCCCTCCCTGTCAAAGCTGTCACTTCGCGTGCCCTCGCTGCTTCTGTGTGTGGTGAGCAGAAGTGG
AGCTGGGGGGCGTGGAGAGCCCGGCGCCCCTGCCACCTCCCTGACCCGTCTAATATATAAATATAGAGATGTGTCTATGG
CTGAC