(ATF4) activating transcription factor 4 (tax-responsive enhancer element B67) [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  10560
 Official symbol  ATF4
 Official name  activating transcription factor 4 (tax-responsive enhancer element B67)
 Gene type  gene with protein product
 Organism  Homo sapiens
 Location  Chromosome 22 (NC_000022.10) :  39916568...39918690  (+)
 Map  22q13.1
 Length  2123  nt
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Alternative name(s) and Synynom(s) top
Synonyms CREB2; TXREB; TAXREB67; CREB-2
Alternative name(s) cAMP response element-binding protein 2
External Links top
Ensembl ENSG00000128272
Entrez 468
HGNC 786
HPRD 06817
Comment top
Summary This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. [provided by RefSeq].
Bibliography top
Related Articles in PubMed
Genomic Context top
Go to ensembl   www.ensembl.org
Sequence top
FASTA
1  ATTTCTACTT TGCCCGCCCA CAGATGTAGT TTTCTCTGCG CGTGTGCGTT TTCCCTCCTC CCCGCCCTCA GGGTCCACGG
81  CCACCATGGC GTATTAGGGG CAGCAGTGCC TGCGGCAGCA TTGGCCTTTG CAGCGGCGGC AGCAGCACCA GGCTCTGCAG
161  CGGCAACCCC CAGCGGCTTA AGCCATGGCG TGAGTACCGG GGCGGGTCGT CCAGCTGTGC TCCTGGGGCC GGCGCGGGTT
241  TTGGATTGGT GGGGTGCGGC CTGGGGCCAG GGCGGTGCCG CCAAGGGGGA AGCGATTTAA CGAGCGCCCG GGACGCGTGG
321  TCTTTGCTTG GGTGTCCCCG AGACGCTCGC GTGCCTGGGA TCGGGAAAGC GTAGTCGGGT GCCCGGACTG CTTCCCCAGG
401  AGCCCTACAG CCCTCGGACC CCGAGCCCCG CAAGGGTCCC AGGGGTCTTG GCTGTTGCCC CACGAAACGT GGCAGGAACC
481  AAGATGGCGG CGGCAGGGCG GCGGCGCGGG CGTGAGTCAA GGGCGGGCGG TGGGCGGGGC GCGGCCGCCC TGGCCGTATT
561  TGGACGTGGG GACGGAGCGC TTTCCTCTTG GCGGCCGGTG GAAGAATCCC CTGGTCTCCG TGAGCGTCCA TTTTGTGGAA
641  CCTGAGTTGC AAGCAGGGAG GGGCAAATAC AACTGCCCTG TTCCCGATTC TCTAGATGGC CGATCTAGAG AAGTCCCGCC
721  TCATAAGTGG AAGGATGAAA TTCTCAGAAC AGCTAACCTC TAATGGGAGT TGGCTTCTGA TTCTCATTCA GGCTTCTCAC
801  GGCATTCAGC AGCAGCGTTG CTGTAACCGA CAAAGACACC TTCGAATTAA GCACATTCCT CGATTCCAGC AAAGCACCGC
881  AACATGACCG AAATGAGCTT CCTGAGCAGC GAGGTGTTGG TGGGGGACTT GATGTCCCCC TTCGACCAGT CGGGTTTGGG
961  GGCTGAAGAA AGCCTAGGTC TCTTAGATGA TTACCTGGAG GTGGCCAAGC ACTTCAAACC TCATGGGTTC TCCAGCGACA
1041  AGGCTAAGGC GGGCTCCTCC GAATGGCTGG CTGTGGATGG GTTGGTCAGT CCCTCCAACA ACAGCAAGGG TGAGTGGGCC
1121  ACCACCACAT CGTCCTGGTG GGATCTAGGG TTAGGGGCCT CCTACCTTTG TATCTGACTC ACTTGGCCCC ATCACTCAAA
1201  TGTTTTGCAG AGGATGCCTT CTCCGGGACA GATTGGATGT TGGAGAAAAT GGATTTGAAG GAGTTCGACT TGGATGCCCT
1281  GTTGGGTATA GATGACCTGG AAACCATGCC AGATGACCTT CTGACCACGT TGGATGACAC TTGTGATCTC TTTGCCCCCC
1361  TAGTCCAGGA GACTAATAAG CAGCCCCCCC AGACGGTGAA CCCAATTGGC CATCTCCCAG AAAGTTTAAC AAAACCCGAC
1441  CAGGTTGCCC CCTTCACCTT CTTACAACCT CTTCCCCTTT CCCCAGGGGT CCTGTCCTCC ACTCCAGATC ATTCCTTTAG
1521  TTTAGAGCTG GGCAGTGAAG TGGATATCAC TGAAGGAGAT AGGAAGCCAG ACTACACTGC TTACGTTGCC ATGATCCCTC
1601  AGTGCATAAA GGAGGAAGAC ACCCCTTCAG ATAATGATAG TGGCATCTGT ATGAGCCCAG AGTCCTATCT GGGGTCTCCT
1681  CAGCACAGCC CCTCTACCAG GGGCTCTCCA AATAGGAGCC TCCCATCTCC AGGTGTTCTC TGTGGGTCTG CCCGTCCCAA
1761  ACCTTACGAT CCTCCTGGAG AGAAGATGGT AGCAGCAAAA GTAAAGGGTG AGAAACTGGA TAAGAAGCTG AAAAAAATGG
1841  AGCAAAACAA GACAGCAGCC ACTAGGTACC GCCAGAAGAA GAGGGCGGAG CAGGAGGCTC TTACTGGTGA GTGCAAAGAG
1921  CTGGAAAAGA AGAACGAGGC TCTAAAAGAG AGGGCGGATT CCCTGGCCAA GGAGATCCAG TACCTGAAAG ATTTGATAGA
2001  AGAGGTCCGC AAGGCAAGGG GGAAGAAAAG GGTCCCCTAG TTGAGGATAG TCAGGAGCGT CAATGTGCTT GTACATAGAG
2081  TGCTGTAGCT GTGTGTTCCA ATAAATTATT TTGTAGGGAA AGT
>ref|Gene_ID:468|ATF4|NC_000022.10:39916568...39918690 (+)
ATTTCTACTTTGCCCGCCCACAGATGTAGTTTTCTCTGCGCGTGTGCGTTTTCCCTCCTCCCCGCCCTCAGGGTCCACGG
CCACCATGGCGTATTAGGGGCAGCAGTGCCTGCGGCAGCATTGGCCTTTGCAGCGGCGGCAGCAGCACCAGGCTCTGCAG
CGGCAACCCCCAGCGGCTTAAGCCATGGCGTGAGTACCGGGGCGGGTCGTCCAGCTGTGCTCCTGGGGCCGGCGCGGGTT
TTGGATTGGTGGGGTGCGGCCTGGGGCCAGGGCGGTGCCGCCAAGGGGGAAGCGATTTAACGAGCGCCCGGGACGCGTGG
TCTTTGCTTGGGTGTCCCCGAGACGCTCGCGTGCCTGGGATCGGGAAAGCGTAGTCGGGTGCCCGGACTGCTTCCCCAGG
AGCCCTACAGCCCTCGGACCCCGAGCCCCGCAAGGGTCCCAGGGGTCTTGGCTGTTGCCCCACGAAACGTGGCAGGAACC
AAGATGGCGGCGGCAGGGCGGCGGCGCGGGCGTGAGTCAAGGGCGGGCGGTGGGCGGGGCGCGGCCGCCCTGGCCGTATT
TGGACGTGGGGACGGAGCGCTTTCCTCTTGGCGGCCGGTGGAAGAATCCCCTGGTCTCCGTGAGCGTCCATTTTGTGGAA
CCTGAGTTGCAAGCAGGGAGGGGCAAATACAACTGCCCTGTTCCCGATTCTCTAGATGGCCGATCTAGAGAAGTCCCGCC
TCATAAGTGGAAGGATGAAATTCTCAGAACAGCTAACCTCTAATGGGAGTTGGCTTCTGATTCTCATTCAGGCTTCTCAC
GGCATTCAGCAGCAGCGTTGCTGTAACCGACAAAGACACCTTCGAATTAAGCACATTCCTCGATTCCAGCAAAGCACCGC
AACATGACCGAAATGAGCTTCCTGAGCAGCGAGGTGTTGGTGGGGGACTTGATGTCCCCCTTCGACCAGTCGGGTTTGGG
GGCTGAAGAAAGCCTAGGTCTCTTAGATGATTACCTGGAGGTGGCCAAGCACTTCAAACCTCATGGGTTCTCCAGCGACA
AGGCTAAGGCGGGCTCCTCCGAATGGCTGGCTGTGGATGGGTTGGTCAGTCCCTCCAACAACAGCAAGGGTGAGTGGGCC
ACCACCACATCGTCCTGGTGGGATCTAGGGTTAGGGGCCTCCTACCTTTGTATCTGACTCACTTGGCCCCATCACTCAAA
TGTTTTGCAGAGGATGCCTTCTCCGGGACAGATTGGATGTTGGAGAAAATGGATTTGAAGGAGTTCGACTTGGATGCCCT
GTTGGGTATAGATGACCTGGAAACCATGCCAGATGACCTTCTGACCACGTTGGATGACACTTGTGATCTCTTTGCCCCCC
TAGTCCAGGAGACTAATAAGCAGCCCCCCCAGACGGTGAACCCAATTGGCCATCTCCCAGAAAGTTTAACAAAACCCGAC
CAGGTTGCCCCCTTCACCTTCTTACAACCTCTTCCCCTTTCCCCAGGGGTCCTGTCCTCCACTCCAGATCATTCCTTTAG
TTTAGAGCTGGGCAGTGAAGTGGATATCACTGAAGGAGATAGGAAGCCAGACTACACTGCTTACGTTGCCATGATCCCTC
AGTGCATAAAGGAGGAAGACACCCCTTCAGATAATGATAGTGGCATCTGTATGAGCCCAGAGTCCTATCTGGGGTCTCCT
CAGCACAGCCCCTCTACCAGGGGCTCTCCAAATAGGAGCCTCCCATCTCCAGGTGTTCTCTGTGGGTCTGCCCGTCCCAA
ACCTTACGATCCTCCTGGAGAGAAGATGGTAGCAGCAAAAGTAAAGGGTGAGAAACTGGATAAGAAGCTGAAAAAAATGG
AGCAAAACAAGACAGCAGCCACTAGGTACCGCCAGAAGAAGAGGGCGGAGCAGGAGGCTCTTACTGGTGAGTGCAAAGAG
CTGGAAAAGAAGAACGAGGCTCTAAAAGAGAGGGCGGATTCCCTGGCCAAGGAGATCCAGTACCTGAAAGATTTGATAGA
AGAGGTCCGCAAGGCAAGGGGGAAGAAAAGGGTCCCCTAGTTGAGGATAGTCAGGAGCGTCAATGTGCTTGTACATAGAG
TGCTGTAGCTGTGTGTTCCAATAAATTATTTTGTAGGGAAAGT